﻿                         序列表

<110>  正大天晴药业集团股份有限公司

<120>  含抗TSLP抗体的药物组合物

<150>  CN202110235660.8
<151>  2021-03-03

<160>  38

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠、嵌合和人源化抗体1C5F12E9的VH-CDR1


<400>  1
Thr Tyr Trp Met His 
1               5   

<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠、嵌合和人源化抗体1C5F12E9的VH-CDR2


<400>  2
Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠、嵌合和人源化抗体1C5F12E9的VH-CDR3


<400>  3
Ser Leu Asp Gly Tyr Tyr Asp Tyr 
1               5               

<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠、嵌合和人源化抗体1C5F12E9的VL-CDR1


<400>  4
Arg Pro Thr Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      

<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠、嵌合和人源化抗体1C5F12E9的VL-CDR2


<400>  5
Phe Ala Arg Thr Leu Ala Glu 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠、嵌合和人源化抗体1C5F12E9的VL-CDR3


<400>  6
Gln His His Tyr Gly Thr Pro Trp Thr 
1               5                   

<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠和嵌合抗体1C5F12E9的VH


<400>  7
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Ser Leu Asp Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Leu Thr Val Ser Ser 
        115         

<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  hu1C5F12E9-V1, hu1C5F12E9-V7和hu1C5F12E9-V13的VH


<400>  8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Ser Leu Asp Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<222>  (67)
<223>  Xaa can be Arg or Lys


<220>
<221>  UNSURE
<222>  (68)
<223>  Xaa can be Val or Ala


<220>
<221>  UNSURE
<222>  (72)
<223>  Xaa can be Arg or Val


<220>
<221>  UNSURE
<223>  hu1C5F12E9-V2 - hu1C5F12E9-V6, hu1C5F12E9-V8 - hu1C5F12E9-V12和hu1C5F12E9-V14 - hu1C5F12E9-V18的VH


<400>  9
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Xaa Xaa Thr Met Thr Xaa Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Ser Leu Asp Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠和嵌合抗体1C5F12E9的VL


<400>  10
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Pro Thr Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              
Tyr Phe Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<222>  (43)
<223>  Xaa can Ser or Ala


<220>
<221>  UNSURE
<222>  (48)
<223>  Xaa can be Val or Ile


<220>
<221>  UNSURE
<223>  hu1C5F12E9-V1 - hu1C5F12E9-V18的VL


<400>  11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Pro Thr Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Xaa 
        35                  40                  45              
Tyr Phe Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  12
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人IgG1重链恒定区


<400>  12
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  13
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人IgG4重链恒定区


<400>  13
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人κ轻链恒定区


<400>  14
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  15
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠IgG1重链恒定区


<400>  15
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 
Ser Pro Gly Lys 
                

<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  小鼠κ轻链恒定区


<400>  16
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      
Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  17
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  小鼠和嵌合抗体1C5F12E9的VH


<400>  17
caggtccaac tgcagcagcc tgggactgag ctggtgaagc ctggggcttc agtgaagatg        60
tcctgcaagg cttctggcta caccttcacc acctactgga tgcactgggt gaagcagagg       120
cctggacaag gccttgagtg gatcggagtg attgatcctt ctgatagtga tactacctac       180
aatcaaaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagcctac       240
atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtac aaggtccctt       300
gatggttact acgactactg gggccaaggc accactctca cagtctcctc a                351

<210>  18
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  小鼠和嵌合抗体1C5F12E9的VH


<400>  18
caggtgcagc tgcagcagcc cggcaccgag ctggtgaagc ctggcgctag cgtgaagatg        60
tcctgtaagg ccagcggcta cacattcact acatactgga tgcactgggt gaagcagaga       120
cctggccagg gcctggagtg gatcggcgtg atcgacccca gcgactccga taccacctac       180
aaccagaagt ttaagggcaa ggccaccctg acagtggata caagctcctc cacagcctac       240
atgcagctgt ccagcctgac ctccgaggat tccgccgtgt actactgcac aaggtccctg       300
gatggctact acgattactg gggccagggc acaaccctga cagtcagcag c                351

<210>  19
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  hu1C5F12E9-V2, hu1C5F12E9-V8和hu1C5F12E9-V14的VH


<400>  19
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ctggcgcctc cgtgaaggtg        60
tcctgcaagg ccagcggcta cacattcacc acatactgga tgcactgggt gagacaggcc       120
cccggccagg gactggagtg gatgggagtg atcgacccca gcgactccga cacaacctac       180
aaccagaagt tcaagggcag ggtgacaatg accagagaca ccagcacaag caccgtgtac       240
atggagctgt cctccctgag gagcgaggac accgccgtgt actactgcac cagatccctg       300
gacggctact acgactactg gggccagggc accctggtga cagtgtccag c                351

<210>  20
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  小鼠和嵌合抗体1C5F12E9的VL


<400>  20
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc        60
atcacatgtc gaccaactga gaatatttac agttatttag catggtatca gcagaaacag       120
ggaaaatctc ctcacctcct ggtctatttt gcaagaacct tagcagaagg tgtgccatca       180
aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct       240
gaagattttg ggatttatta ctgtcaacac cattatggta ctccgtggac gttcggtgga       300
ggcaccaagc tggaaatcaa a                                                 321

<210>  21
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  小鼠和嵌合抗体1C5F12E9的VL


<400>  21
gacatccaga tgacccagtc ccccgccagc ctgtccgcct ctgtgggaga gaccgtgacc        60
atcacatgca ggcccaccga gaatatctac tcctacctgg cctggtatca acagaagcag       120
ggcaagagcc ctcacctgct ggtgtacttc gccaggacac tggccgaggg cgtgccctct       180
aggttcagcg gcagcggctc cggcacacag ttttccctga agatcaacag cctgcagcct       240
gaggattttg gcatctacta ctgccagcac cactacggca caccctggac ctttggcggc       300
ggcaccaagc tggagatcaa g                                                 321

<210>  22
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  hu1C5F12E9-V7 - hu1C5F12E9-V12的VL


<400>  22
gatatccaga tgacacagag ccccagcagc ctgagcgcca gcgtgggaga cagggtgaca        60
atcacatgca gacccaccga gaatatctac agctacctgg cctggtatca acagaagcct       120
ggcaaggccc ccaagctgct gatctacttc gccagaaccc tggccgaggg cgtgccctct       180
aggttcagcg gctccggcag cggcaccgac ttcacactga ccatctcctc cctgcagccc       240
gaggacttcg ccacatacta ctgccagcac cactacggca caccttggac cttcggcggc       300
ggcacaaagg tggagatcaa g                                                 321

<210>  23
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  人IgG1重链恒定区


<400>  23
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag       720
atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg       840
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg       900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg       960
cagaagagcc tctccctgtc tccgggtaaa tga                                    993

<210>  24
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  人IgG4重链恒定区


<400>  24
gccagcacaa agggcccttc cgtgtttccc ctggccccct gcagcaggag cacctctgag        60
tccaccgccg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc       120
tggaattccg gcgccctgac atccggcgtg cacaccttcc ccgccgtgct gcagtcctcc       180
ggcctgtaca gcctgagctc cgtggtgaca gtgccttcct cctccctggg caccaagacc       240
tacacatgta atgtggatca caagcccagc aacacaaagg tggataagag agtggagtcc       300
aagtacggcc ctccttgccc tccctgtcct gccccagagt tcctgggcgg cccctctgtg       360
ttcctgttcc cccctaagcc caaggacaca ctgatgatct ccaggacccc tgaggtgacc       420
tgcgtggtgg tggacgtgag ccaggaggac cctgaggtgc agttcaattg gtacgtggat       480
ggcgtggagg tgcacaatgc caagacaaag cccagagagg agcagtttaa ttccacatac       540
agggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa ggagtacaag       600
tgtaaggtga gcaacaaggg cctgccttcc tccatcgaga agacaatcag caaggccaag       660
ggccagccta gggagcccca ggtgtacaca ctgcctccca gccaggagga gatgaccaag       720
aaccaggtga gcctgacctg cctggtgaag ggcttctacc ctagcgacat cgccgtggag       780
tgggagtcca acggccagcc cgagaataac tacaagacaa caccccccgt gctggattcc       840
gatggcagct tctttctgta ctccaggctg accgtggata agagcaggtg gcaggagggc       900
aatgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagagc       960
ctgtccctga gcctgggcaa gtga                                              984

<210>  25
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  人κ轻链恒定区


<400>  25
cgtacggtgg cggcgccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct        60
ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag       120
tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac       180
agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag       240
aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag       300
agcttcaaca ggggagagtg ttga                                              324

<210>  26
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  小鼠IgG1重链恒定区


<400>  26
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac        60
tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc       120
tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac       180
ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc       240
acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg       300
gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc       360
cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg       420
gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag       480
gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc       540
agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc       600
aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg       660
aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc       720
agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg       780
aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct       840
tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc       900
acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac       960
tctcctggta aatga                                                        975

<210>  27
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  小鼠κ轻链恒定区


<400>  27
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct        60
ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag       120
tggaagattg atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac       180
agcaaagaca gcacctacag catgagcagc accctcacgt tgactaagga cgagtatgaa       240
cgacataaca gctatacctg tgaggccact cacaagacat caacttcacc cattgtcaag       300
agcttcaaca ggggagagtg t                                                 321

<210>  28
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  重组人TSLP-his


<400>  28
Tyr Asp Phe Thr Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu 
1               5                   10                  15      
Ser Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser 
            20                  25                  30          
Thr Glu Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu 
        35                  40                  45              
Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser 
    50                  55                  60                  
Leu Ala Lys Glu Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile 
65                  70                  75                  80  
Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met 
                85                  90                  95      
Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln 
            100                 105                 110         
Val Ser Gln Leu Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu 
        115                 120                 125             
Lys Gln Gln His His His His His His His His His His 
    130                 135                 140     

<210>  29
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  重组食蟹猴TSLP-his


<400>  29
Met Tyr Asp Phe Thr Asn Cys Asp Phe Gln Lys Ile Glu Ala Asp Tyr 
1               5                   10                  15      
Leu Arg Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys 
            20                  25                  30          
Ser Thr Asp Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys 
        35                  40                  45              
Leu Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Pro Arg Cys Ala 
    50                  55                  60                  
Ser Leu Ala Lys Glu Met Phe Ala Arg Lys Thr Lys Ala Thr Leu Ala 
65                  70                  75                  80  
Leu Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala 
                85                  90                  95      
Met Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu 
            100                 105                 110         
Gln Val Ser Gln Leu Leu Gly Leu Trp Arg Arg Phe Ile Arg Thr Leu 
        115                 120                 125             
Leu Lys Lys Gln Leu Glu His His His His His His 
    130                 135                 140 

<210>  30
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人TSLPR-Fc


<400>  30
Gly Ala Ala Glu Gly Val Gln Ile Gln Ile Ile Tyr Phe Asn Leu Glu 
1               5                   10                  15      
Thr Val Gln Val Thr Trp Asn Ala Ser Lys Tyr Ser Arg Thr Asn Leu 
            20                  25                  30          
Thr Phe His Tyr Arg Phe Asn Gly Asp Glu Ala Tyr Asp Gln Cys Thr 
        35                  40                  45              
Asn Tyr Leu Leu Gln Glu Gly His Thr Ser Gly Cys Leu Leu Asp Ala 
    50                  55                  60                  
Glu Gln Arg Asp Asp Ile Leu Tyr Phe Ser Ile Arg Asn Gly Thr His 
65                  70                  75                  80  
Pro Val Phe Thr Ala Ser Arg Trp Met Val Tyr Tyr Leu Lys Pro Ser 
                85                  90                  95      
Ser Pro Lys His Val Arg Phe Ser Trp His Gln Asp Ala Val Thr Val 
            100                 105                 110         
Thr Cys Ser Asp Leu Ser Tyr Gly Asp Leu Leu Tyr Glu Val Gln Tyr 
        115                 120                 125             
Arg Ser Pro Phe Asp Thr Glu Trp Gln Ser Lys Gln Glu Asn Thr Cys 
    130                 135                 140                 
Asn Val Thr Ile Glu Gly Leu Asp Ala Glu Lys Cys Tyr Ser Phe Trp 
145                 150                 155                 160 
Val Arg Val Lys Ala Met Glu Asp Val Tyr Gly Pro Asp Thr Tyr Pro 
                165                 170                 175     
Ser Asp Trp Ser Glu Val Thr Cys Trp Gln Arg Gly Glu Ile Arg Asp 
            180                 185                 190         
Ala Cys Ala Glu Thr Pro Thr Pro Pro Lys Pro Lys Leu Ser Lys Asp 
        195                 200                 205             
Ile Glu Gly Arg Met Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210>  31
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人IL7Ra-Fc


<400>  31
Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      
Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          
His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn 
        35                  40                  45              
Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  
Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  
Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      
Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         
Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             
Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 
His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 
Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     
Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         
Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             
Pro Glu Ile Asn Asn Ser Ser Gly Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  32
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人TSLP-Fc


<400>  32
Tyr Asp Phe Thr Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu 
1               5                   10                  15      
Ser Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser 
            20                  25                  30          
Thr Glu Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu 
        35                  40                  45              
Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser 
    50                  55                  60                  
Leu Ala Lys Glu Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile 
65                  70                  75                  80  
Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met 
                85                  90                  95      
Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln 
            100                 105                 110         
Val Ser Gln Leu Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu 
        115                 120                 125             
Lys Gln Gln Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    130                 135                 140                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            180                 185                 190         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            260                 265                 270         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                325                 330                 335     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360             

<210>  33
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  33
Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly 
1               5                   10                  15      
Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile 
            20                  25                  30          
Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala 
        35                  40                  45              
Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly 
    50                  55                  60                  
Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His 
65                  70                  75                  80  
Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr 
                85                  90                  95      
Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp 
            100                 105                 110         
Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 
        115                 120                 125             
Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 
    130                 135                 140                 
Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 
145                 150                 155                 160 
Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 
                165                 170                 175     
Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 
            180                 185                 190         
Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 
        195                 200                 205             
Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 
    210                 215                 220                 
Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 
225                 230                 235                 240 
Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 
                245                 250                 255     
Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 
            260                 265                 270         
Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 
        275                 280                 285             
Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 
    290                 295                 300                 
Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 
305                 310                 315                 320 
Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 
                325                 330                 335     
Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 
            340                 345                 350         
Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 
        355                 360                 365             
Val Ala Leu 
    370     

<210>  34
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  34
Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      
Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          
Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              
Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  
Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  
Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      
Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         
Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             
Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 
Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 
Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     
Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         
Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             
Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 
Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 
Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     
Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         
Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             
Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 
Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 
Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     
Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         
Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             
Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 
Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 
Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     
Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         
Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             
Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 

<210>  35
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  Tezepelumab的重链


<400>  35
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Pro Gln Trp Glu Leu Val His Glu Ala Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 
Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  Tezepelumab的轻链


<400>  36
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Leu Gly Ser Lys Ser Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              
Asp Asp Ser Asp Arg Pro Ser Trp Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Gly Glu Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             
Ala Pro Thr Glu Cys Ser 
    210                 

<210>  37
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  UNSURE
<223>  人IgG1重链恒定区


<400>  37
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  38
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<221>  unsure
<223>  人IgG1重链恒定区


<400>  38
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg        60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc       300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga       360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       540
agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc       660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag       720
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc       780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg       840
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg       900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg       960
cagaagagcc tctccctgtc tccgggtaaa tga                                    993

