                         SEQUENCE LISTING

<110>  ϴѧ
 
<120>  һϵͳӦ

<130>  BAA210192A

<150>  CN202110254263.5
<151>  2021-03-05

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  3273
<212>  DNA
<213>  ˹

<400>  1
atggatagcc tgctgatgaa tcgtcgcaaa tttctgtatc agtttaaaaa tgtgcgttgg     60

gccaaaggtc gtcgtgaaac ctatctgtgc tatgttgtga aacgtcgtga tagcgcaacc    120

agctttagcc tggattttgg ttatctgcgc aataaaaatg gttgtcatgt ggagctgctg    180

tttctgcgtt atattagcga ttgggatctg gatccgggtc gttgttatcg tgttacctgg    240

tttaccagct ggtcaccgtg ttatgactgt gcacgtcatg ttgcagattt tctgcgtggt    300

aatccgaatc tgagcctgcg tatttttacc gcacgtctgt atttttgcga agatcgtaaa    360

gcagaaccgg aaggtctgcg tcgtctgcat cgtgcaggtg ttcagattgc cattatgacc    420

tttaaagatt atttttattg ctggaatacc tttgtggaaa atcatgaacg cacctttaaa    480

gcatgggaag gcctgcatga aaatagcgtt cgtctgtctc gccagctgcg tcgtattctg    540

ctgccgctgt atgaagttga tgatctgcgt gatgcctttc gtaccctggg tttaaccggt    600

caggaagttg catgcaccgc cggcaacacg attaacatcg ctaagaacga cttctctgac    660

atcgaactgg ctgctatccc gttcaacact ctggctgacc attacggtga gcgtttagct    720

cgcgaacagt tggcccttga gcatgagtct tacgagatgg gtgaagcacg cttccgcaag    780

atgtttgagc gtcaacttaa agctggtgag gttgcggata acgctgccgc caagcctctc    840

atcactaccc tactccctaa gatgattgca cgcatcaacg actggtttga ggaagtgaaa    900

gctaagcgcg gcaagcgccc gacagccttc cagttcctgc aagaaatcaa gccggaagcc    960

gtagcgtaca tcaccattaa gaccactctg gcttgcctaa ccagtgctga caatacaacc   1020

gttcaggctg tagcaagcgc aatcggtcgg gccattgagg acgaggctcg cttcggtcgt   1080

atccgtgacc ttgaagctaa gcacttcaag aaaaacgttg aggaacaact caacaagcgc   1140

gtagggcacg tctacaagaa agcatttatg caagttgtcg aggctgacat gctctctaag   1200

ggtctactcg gtggcgaggc gtggtcttcg tggcataagg aagactctat tcatgtagga   1260

gtacgctgca tcgagatgct cattgagtca accggaatgg ttagcttaca ccgccaaaat   1320

gctggcgtag taggtcaaga ctctgagact atcgaactcg cacctgaata cgctgaggct   1380

atcgcaaccc gtgcaggtgc gctggctggc atctctccga tgttccaacc ttgcgtagtt   1440

cctcctaagc cgtggactgg cattactggt ggtggctatt gggctaacgg tcgtcgtcct   1500

ctggcgctgg tgcgtactca cagtaagaaa gcactgatgc gctacgaaga cgtttacatg   1560

cctgaggtgt acaaagcgat taacattgcg caaaacaccg catggaaaat caacaagaaa   1620

gtcctagcgg tcgccaacgt aatcaccaag tggaagcatt gtccggtcga ggacatccct   1680

gcgattgagc gtgaagaact cccgatgaaa ccggaagaca tcgacatgaa tcctgaggct   1740

ctcaccgcgt ggaaacgtgc tgccgctgct gtgtaccgca aggacagggc tcgcaagtct   1800

cgccgtatca gccttgagtt catgcttgag caagccaata agtttgctaa ccataaggcc   1860

atctggttcc cttacaacat ggactggcgc ggtcgtgttt acgccgtgtc aatgttcaac   1920

ccgcaaggta acgatatgac caaaggactg cttacgctgg cgaaaggtaa accaatcggt   1980

aaggaaggtt actactggct gaaaatccac ggtgcaaact gtgcgggtgt cgataaggtt   2040

ccgttccctg agcgcatcaa gttcattgag gaaaaccacg agaacatcat ggcttgcgct   2100

aagtctccac tggagaacac ttggtgggct gagcaagatt ctccgttctg cttccttgcg   2160

ttctgctttg agtacgctgg ggtacagcac cacggcctga gctataactg ctcccttccg   2220

ctggcgtttg acgggtcttg ctctggcatc cagcacttct ccgcgatgct ccgagatgag   2280

gtaggtggtc gcgcggttaa cttgcttcct agtgagaccg ttcaggacat ctacgggatt   2340

gttgctaaga aagtcaacga gattctacaa gcagacgcaa tcaatgggac cgataacgaa   2400

gtagttaccg tgaccgatga gaacactggt gaaatctctg agaaagtcaa gctgggcact   2460

aaggcactgg ctggtcaatg gctggctcac ggtgttactc gcagtgtgac taagcgttca   2520

gtcatgacgc tggcttacgg gtccaaagag ttcggcttcc gtcaacaagt gctggaagat   2580

accattcagc cagctattga ttccggcaag ggtccgatgt tcactcagcc gaatcaggct   2640

gctggataca tggctaagct gatttgggaa tctgtgagcg tgacggtggt agctgcggtt   2700

gaagcaatga actggcttaa gtctgctgct aagctgctgg ctgctgaggt caaagataag   2760

aagactggag agattcttcg caagcgttgc gctgtgcatt gggtaactcc tgatggtttc   2820

cctgtgtggc aggaatacaa gaagcctatt cagaagcgct tggacatgat tttcctcggt   2880

cagttccgct tacagcctac cattaacacc aacaaagata gcgagattga tgcacgcaaa   2940

caggtgtctg gtatcgctcc taactttgta cacagccaag acggtagcca ccttcgtaag   3000

actgtagtgt gggcacacga gaagtacgga atcgaatctt ttgcactgat tcacgactcc   3060

ttcggtacca ttccggctga cgctgcgaac ctgttcaaag cagtgcgcga aactatggtt   3120

gacacatatg agtcttgtga tgtactggct gatttctacg accagttcgc tgaccagttg   3180

cacgagtctc aattggacaa aatgccagca cttccggcta aaggtaactt gaacctccgt   3240

gacatcttag agtcggactt cgcgttcgcg taa                                3273


<210>  2
<211>  1090
<212>  PRT
<213>  ˹

<400>  2

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu Thr Gly Gln Glu Val Ala Cys Thr Ala Gly 
        195                 200                 205             


Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu Ala 
    210                 215                 220                 


Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu Ala 
225                 230                 235                 240 


Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu Ala 
                245                 250                 255     


Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val Ala 
            260                 265                 270         


Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys Met 
        275                 280                 285             


Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg Gly 
    290                 295                 300                 


Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu Ala 
305                 310                 315                 320 


Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser Ala 
                325                 330                 335     


Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala Ile 
            340                 345                 350         


Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys His 
        355                 360                 365             


Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His Val 
    370                 375                 380                 


Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser Lys 
385                 390                 395                 400 


Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp Ser 
                405                 410                 415     


Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr Gly 
            420                 425                 430         


Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp Ser 
        435                 440                 445             


Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr Arg 
    450                 455                 460                 


Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val Val 
465                 470                 475                 480 


Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala Asn 
                485                 490                 495     


Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala Leu 
            500                 505                 510         


Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile Asn 
        515                 520                 525             


Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala Val 
    530                 535                 540                 


Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile Pro 
545                 550                 555                 560 


Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp Met 
                565                 570                 575     


Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val Tyr 
            580                 585                 590         


Arg Lys Asp Arg Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe Met 
        595                 600                 605             


Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe Pro 
    610                 615                 620                 


Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe Asn 
625                 630                 635                 640 


Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys Gly 
                645                 650                 655     


Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly Ala 
            660                 665                 670         


Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys Phe 
        675                 680                 685             


Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro Leu 
    690                 695                 700                 


Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu Ala 
705                 710                 715                 720 


Phe Cys Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr Asn 
                725                 730                 735     


Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln His 
            740                 745                 750         


Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn Leu 
        755                 760                 765             


Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys Lys 
    770                 775                 780                 


Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn Glu 
785                 790                 795                 800 


Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys Val 
                805                 810                 815     


Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala His Gly Val 
            820                 825                 830         


Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly Ser 
        835                 840                 845             


Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln Pro 
    850                 855                 860                 


Ala Ile Asp Ser Gly Lys Gly Pro Met Phe Thr Gln Pro Asn Gln Ala 
865                 870                 875                 880 


Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr Val 
                885                 890                 895     


Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys Leu 
            900                 905                 910         


Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg Lys 
        915                 920                 925             


Arg Cys Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp Gln 
    930                 935                 940                 


Glu Tyr Lys Lys Pro Ile Gln Lys Arg Leu Asp Met Ile Phe Leu Gly 
945                 950                 955                 960 


Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu Ile 
                965                 970                 975     


Asp Ala Arg Lys Gln Val Ser Gly Ile Ala Pro Asn Phe Val His Ser 
            980                 985                 990         


Gln Asp Gly Ser His Leu Arg Lys  Thr Val Val Trp Ala  His Glu Lys 
        995                 1000                 1005             


Tyr Gly  Ile Glu Ser Phe Ala  Leu Ile His Asp Ser  Phe Gly Thr 
    1010                 1015                 1020             


Ile Pro  Ala Asp Ala Ala Asn  Leu Phe Lys Ala Val  Arg Glu Thr 
    1025                 1030                 1035             


Met Val  Asp Thr Tyr Glu Ser  Cys Asp Val Leu Ala  Asp Phe Tyr 
    1040                 1045                 1050             


Asp Gln  Phe Ala Asp Gln Leu  His Glu Ser Gln Leu  Asp Lys Met 
    1055                 1060                 1065             


Pro Ala  Leu Pro Ala Lys Gly  Asn Leu Asn Leu Arg  Asp Ile Leu 
    1070                 1075                 1080             


Glu Ser  Asp Phe Ala Phe Ala  
    1085                 1090 


<210>  3
<211>  63
<212>  PRT
<213>  ˹

<400>  3

Met Asn Ser Ala Phe Val Leu Val Leu Thr Val Phe Leu Val Ser Gly 
1               5                   10                  15      


Glu Pro Val Asp Ile Ala Val Ser Val His Arg Thr Met Gln Glu Cys 
            20                  25                  30          


Met Thr Ala Ala Thr Glu Gln Lys Ile Pro Gly Asn Cys Tyr Pro Val 
        35                  40                  45              


Asp Lys Val Ile His Gln Asp Asn Ile Glu Ile Pro Ala Gly Leu 
    50                  55                  60              


<210>  4
<211>  170
<212>  PRT
<213>  ˹

<400>  4

Met Gly Tyr Thr Ser Gly Tyr Ala His Arg Ser Ser Ser Phe Ser Ser 
1               5                   10                  15      


Ala Ala Ser Lys Ile Ala Arg Val Ser Thr Glu Asn Thr Thr Ala Gly 
            20                  25                  30          


Leu Ile Ser Glu Val Val Tyr Arg Glu Asp Gln Pro Met Met Thr Gln 
        35                  40                  45              


Leu Leu Leu Leu Pro Leu Leu Gln Gln Leu Gly Gln Gln Ser Arg Trp 
    50                  55                  60                  


Gln Leu Trp Leu Thr Pro Gln Gln Lys Leu Ser Arg Glu Trp Val Gln 
65                  70                  75                  80  


Ala Ser Gly Leu Pro Leu Thr Lys Val Met Gln Ile Ser Gln Leu Ser 
                85                  90                  95      


Pro Cys His Thr Val Glu Ser Met Val Arg Ala Leu Arg Thr Gly Asn 
            100                 105                 110         


Tyr Ser Val Val Ile Gly Trp Leu Ala Asp Asp Leu Thr Glu Glu Glu 
        115                 120                 125             


His Ala Glu Leu Val Asp Ala Ala Asn Glu Gly Asn Ala Met Gly Phe 
    130                 135                 140                 


Ile Met Arg Pro Val Ser Ala Ser Ser His Ala Thr Arg Gln Leu Ser 
145                 150                 155                 160 


Gly Leu Lys Ile His Ser Asn Leu Tyr His 
                165                 170 


<210>  5
<211>  1648
<212>  DNA
<213>  ˹

<400>  5
atgaccggta tctcttctaa aaaagctacc atctacgacc tgtctatcct gtctggtgct     60

tctgcttcta ccgtttctgc tgttctgaac ggttcttggc gtaaacgtcg tatctctgaa    120

gaaaccgctg acaaaatcct gtctctggct aaagctcagc gttacaccac caacttacag    180

gctcgtggtc tgcgttcttc taaatctggt ctggttggtc tgctggttcc ggtttacgac    240

aaccgtttct tctcttctat ggctcagacc ttcgaaggtc aggctcgtaa acgtggtctg    300

tctccgatgg ttgtttctgg tcgtcgtgac ccggaagaag aacgtcgtac cgttgaaacc    360

ctgatcgctt actctatcga cgctctgttc atcgctggtg ttaccgaccc ggacggtgtt    420

caccaggttt gcgctcgtgc tgctctgccg cacgttaaca tcgacctgcc gggtaaattc    480

gcttcttctg ttatctctaa caaccgtcac ggtgctgaaa tcctgaccgc tgctatcctg    540

gctcacgctg ctaaaggtgg ttctctgggt ccggacgacg ttatcctgtt cggtggtcac    600

gacgaccacg cttctcgtga acgtatcgac ggtttccacg ctgctaaagc tgactacttc    660

ggtgttgaag gtggtgacga catcgaaatc accggttact ctccgcacat gaccgaaatg    720

gctttcgaac gtttcttcgg tcgtcgtggt cgtctgccgc gttgcttctt cgttaactct    780

tctatcaact tcgaaggtct gctgcgtttc atgggtcgtc acgacggtga agctttcggt    840

gacatcgttg ttggttgctt cgactacgac ccgttcgctt ctttcctgcc gttcccggtt    900

tacatgatca aaccggacat cgctcagatg ctggaaaaag gtttcgaact gctggaagaa    960

aaccgtaccg aaccggaagt taccatcatc gaaccgcagc tgatcccgcc gcgtaccgct   1020

ctggaaggtc cgctggacga catctgggac ccggttgctc tgcgtcgtat ggctaaataa   1080

agcaggcatg cccaggcatc aaataaaacg aaaggctcag tcgaaagact gggcctttcg   1140

ttttatctgt tgtttgtcgg tgaacgctct ctactagagt cacactggct caccttcggg   1200

tgggcctttc tgcgtttata acgtacgtac gtacgtggat cccttggagt ataaatggtg   1260

gctttttttg aacttatgcc cgtcactgtg atctccccaa ctgattccga ttattagagc   1320

acgcatcccc ttgacggaag ggcgcttcat gatatggtta ttgcaccatc gattgtgcag   1380

attggcaata tcgattgtgc atggtggttg ctatgggagt ggcaagggag agtctcgaat   1440

aagcgagatg agagattttg aacgcgtccg ggaaaaacgg gctgcgggcg gatttcgttt   1500

gccgaatttt tgaggaggaa catcaatgaa gaaaattatt gctgcggcgg ttggtctgtc   1560

gctggcgttg ctctcatccg cagcctttgc cgaagggccg aaggtgggcg tcgtcgtcaa   1620

gatcggcggc attccgtggt tcaacgcc                                      1648


<210>  6
<211>  885
<212>  DNA
<213>  ˹

<400>  6
atgaagcacg gcatctacta cgcctactgg gagcaggagt gggaggccga ctacaagtac     60

tacatcgaga aggtggccaa gctgggcttc gacatcctgg agatcgccgc cagccccctg    120

cccttctaca gcgacatcca gatcaacgag ctgaaggcct gcgcccacgg caacggcatc    180

accctgaccg tgggccacgg ccccagcgcc gagcagaacc tgagcagccc cgaccccgac    240

atcaggaaga acgccaaggc cttctacacc gacctgctga agaggctgta caagctggac    300

gtgcacctga tcggcggcgc cctgtacagc tactggccca tcgactacac caagaccatc    360

gacaagaagg gcgactggga gaggagcgtg gagagcgtga gggaggtggc caaggtggcc    420

gaggcctgcg gcgtggactt ctgcctggag gtgctgaaca ggttcgagaa ctacctgatc    480

aacaccgccc aggagggcgt ggacttcgtg aagcaggtgg accacaacaa cgtgaaggtg    540

atgctggaca ccttccacat gaacatcgag gaggacagca tcggcggcgc catcaggacc    600

gccggcagct acctgggcca cctgcacacc ggcgagtgca acaggaaggt gcccggcagg    660

ggcaggatcc cctgggtgga gatcggcgag gccctggccg acatcggcta caacggcagc    720

gtggtgatgg agcccttcgt gaggatgggc ggcaccgtgg gcagcaacat caaggtgtgg    780

agggacatca gcaacggcgc cgacgagaag atgctggaca gggaggccca ggccgccctg    840

gacttcagca ggtacgtgct ggagtgccac aagcacagcc tggag                    885


