                         б

<110>  Ƽɷ޹˾
 
<120>  һָЧ͸ˮøĻ﷽

<130>  TFE00376PCT

<150>  CN202110246672.0
<151>  2021-03-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  1074
<212>  DNA
<213>  ˹

<220>
<223>  ˹ϳ

<400>  1
atgatcccac ccgcacgtga ctcgcttatg tttgtctttg cgactgcggt aatcgctagt       60

tttttcggta gcgcaaagac actacgcggc tcttccccac agcaattcga cgtatactgg      120

aatgtgccaa ctttcatgtg tcacaagcac ggtatgaaat ttgaagagct gaaagatttc      180

ggtatacacc agaacgcaat ggatatgttt cgcggcgaag aaattgcgat tctttatgac      240

cctggcatgt ttcccgccct tctagtagat aaagatggat acgtcactaa acggaacggt      300

ggggtgccgc aagaggggaa cctcaaggaa catttagaaa cctttagaaa gcatctgacg      360

acacaaattc cggacgagag ctttagcggg ataggaatca tagactttga gagttggaga      420

ccgattttca ggcagaactg ggcgtcactc gagccctata aaactttgtc cataaagttg      480

gagagggaaa aacacccatt ttggtcggag gcagctgtga agaaggaggc caaacgtcga      540

ttcgagaaat ccgggcgaat atttatggag gaaaccctca aaatggccaa aaaactaaga      600

ccgaaagcaa agtggggcta ttatgggtat ccccactgtt tcaatcaaac ccctggacag      660

cagtcggttc actgcaatcg gcaaacgatg atggaaaatg acggtatgag ttggctgttt      720

acactcgaag acgttcatgc tcccagcgtt tacctacgat tggaaatcaa ggaggatgac      780

cggccttcat tcgtgaaagg ccgggtttcc gaggccttaa ggttagccgc taaatcgtct      840

tcaaaacaac gtatcctacc ttactactgg ttcatttatc aggataagaa ggatgagttc      900

ttaacggaaa aggatacaca aaacactata aatatgatcg ctaatctggg atctaatggt      960

ttcataattt ggggatctag tgacgatgtc aacacggaac gcaaatgcaa ggatttacag     1020

caatacgtaa aggaagtctt gggcccagcg attaagaagt tcacccttca ttga           1074


<210>  2
<211>  357
<212>  PRT
<213>  ˹

<220>
<223>  ˹ϳ

<400>  2

Met Ile Pro Pro Ala Arg Asp Ser Leu Met Phe Val Phe Ala Thr Ala 
1               5                   10                  15      


Val Ile Ala Ser Phe Phe Gly Ser Ala Lys Thr Leu Arg Gly Ser Ser 
            20                  25                  30          


Pro Gln Gln Phe Asp Val Tyr Trp Asn Val Pro Thr Phe Met Cys His 
        35                  40                  45              


Lys His Gly Met Lys Phe Glu Glu Leu Lys Asp Phe Gly Ile His Gln 
    50                  55                  60                  


Asn Ala Met Asp Met Phe Arg Gly Glu Glu Ile Ala Ile Leu Tyr Asp 
65                  70                  75                  80  


Pro Gly Met Phe Pro Ala Leu Leu Val Asp Lys Asp Gly Tyr Val Thr 
                85                  90                  95      


Lys Arg Asn Gly Gly Val Pro Gln Glu Gly Asn Leu Lys Glu His Leu 
            100                 105                 110         


Glu Thr Phe Arg Lys His Leu Thr Thr Gln Ile Pro Asp Glu Ser Phe 
        115                 120                 125             


Ser Gly Ile Gly Ile Ile Asp Phe Glu Ser Trp Arg Pro Ile Phe Arg 
    130                 135                 140                 


Gln Asn Trp Ala Ser Leu Glu Pro Tyr Lys Thr Leu Ser Ile Lys Leu 
145                 150                 155                 160 


Glu Arg Glu Lys His Pro Phe Trp Ser Glu Ala Ala Val Lys Lys Glu 
                165                 170                 175     


Ala Lys Arg Arg Phe Glu Lys Ser Gly Arg Ile Phe Met Glu Glu Thr 
            180                 185                 190         


Leu Lys Met Ala Lys Lys Leu Arg Pro Lys Ala Lys Trp Gly Tyr Tyr 
        195                 200                 205             


Gly Tyr Pro His Cys Phe Asn Gln Thr Pro Gly Gln Gln Ser Val His 
    210                 215                 220                 


Cys Asn Arg Gln Thr Met Met Glu Asn Asp Gly Met Ser Trp Leu Phe 
225                 230                 235                 240 


Thr Leu Glu Asp Val His Ala Pro Ser Val Tyr Leu Arg Leu Glu Ile 
                245                 250                 255     


Lys Glu Asp Asp Arg Pro Ser Phe Val Lys Gly Arg Val Ser Glu Ala 
            260                 265                 270         


Leu Arg Leu Ala Ala Lys Ser Ser Ser Lys Gln Arg Ile Leu Pro Tyr 
        275                 280                 285             


Tyr Trp Phe Ile Tyr Gln Asp Lys Lys Asp Glu Phe Leu Thr Glu Lys 
    290                 295                 300                 


Asp Thr Gln Asn Thr Ile Asn Met Ile Ala Asn Leu Gly Ser Asn Gly 
305                 310                 315                 320 


Phe Ile Ile Trp Gly Ser Ser Asp Asp Val Asn Thr Glu Arg Lys Cys 
                325                 330                 335     


Lys Asp Leu Gln Gln Tyr Val Lys Glu Val Leu Gly Pro Ala Ile Lys 
            340                 345                 350         


Lys Phe Thr Leu His 
        355         


<210>  3
<211>  72
<212>  DNA
<213>  ˹

<220>
<223>  ˹ϳ

<400>  3
atcccacccg cacgtgactc gcttatgttt gtctttgcga ctgcggtaat cgctagtttt       60

ttcggtagcg ca                                                           72


<210>  4
<211>  1020
<212>  DNA
<213>  ˹

<220>
<223>  ˹ϳ

<400>  4
atgaagacac tacgcggctc ttccccacag caattcgacg tatactggaa tgtgccaact       60

ttcatgtgtc acaagcacgg tatgaaattt gaagagctga aagatttcgg tatacaccag      120

aacgcaatgg atatgtttcg cggcgaagaa attgcgattc tttatgaccc tggcatgttt      180

cccgcccttc tagtagataa agatggatac gtcactaaac ggaacggtgg ggtgccgcaa      240

gaggggaacc tcaaggaaca tttagaaacc tttagaaagc atctgacgac acaaattccg      300

gacgagagct ttagcgggat aggaatcata gactttgaga gttggagacc gattttcagg      360

cagaactggg cgtcactcga gccctataaa actttgtcca taaagttgga gagggaaaaa      420

cacccatttt ggtcggaggc agctgtgaag aaggaggcca aacgtcgatt cgagaaatcc      480

gggcgaatat ttatggagga aaccctcaaa atggccaaaa aactaagacc gaaagcaaag      540

tggggctatt atgggtatcc ccactgtttc aatcaaaccc ctggacagca gtcggttcac      600

tgcaatcggc aaacgatgat ggaaaatgac ggtatgagtt ggctgtttac actcgaagac      660

gttcatgctc ccagcgttta cctacgattg gaaatcaagg aggatgaccg gccttcattc      720

gtgaaaggcc gggtttccga ggccttaagg ttagccgcta aatcgtcttc aaaacaacgt      780

atcctacctt actactggtt catttatcag gataagaagg atgagttctt aacggaaaag      840

gatacacaaa acactataaa tatgatcgct aatctgggat ctaatggttt cataatttgg      900

ggatctagtg acgatgtcaa cacggaacgc aaatgcaagg atttacagca atacgtaaag      960

gaagtcttgg gcccagcgat taagaagttc acccttcatc accaccatca tcatcattga     1020


<210>  5
<211>  339
<212>  PRT
<213>  ˹

<220>
<223>  ˹ϳ

<400>  5

Met Lys Thr Leu Arg Gly Ser Ser Pro Gln Gln Phe Asp Val Tyr Trp 
1               5                   10                  15      


Asn Val Pro Thr Phe Met Cys His Lys His Gly Met Lys Phe Glu Glu 
            20                  25                  30          


Leu Lys Asp Phe Gly Ile His Gln Asn Ala Met Asp Met Phe Arg Gly 
        35                  40                  45              


Glu Glu Ile Ala Ile Leu Tyr Asp Pro Gly Met Phe Pro Ala Leu Leu 
    50                  55                  60                  


Val Asp Lys Asp Gly Tyr Val Thr Lys Arg Asn Gly Gly Val Pro Gln 
65                  70                  75                  80  


Glu Gly Asn Leu Lys Glu His Leu Glu Thr Phe Arg Lys His Leu Thr 
                85                  90                  95      


Thr Gln Ile Pro Asp Glu Ser Phe Ser Gly Ile Gly Ile Ile Asp Phe 
            100                 105                 110         


Glu Ser Trp Arg Pro Ile Phe Arg Gln Asn Trp Ala Ser Leu Glu Pro 
        115                 120                 125             


Tyr Lys Thr Leu Ser Ile Lys Leu Glu Arg Glu Lys His Pro Phe Trp 
    130                 135                 140                 


Ser Glu Ala Ala Val Lys Lys Glu Ala Lys Arg Arg Phe Glu Lys Ser 
145                 150                 155                 160 


Gly Arg Ile Phe Met Glu Glu Thr Leu Lys Met Ala Lys Lys Leu Arg 
                165                 170                 175     


Pro Lys Ala Lys Trp Gly Tyr Tyr Gly Tyr Pro His Cys Phe Asn Gln 
            180                 185                 190         


Thr Pro Gly Gln Gln Ser Val His Cys Asn Arg Gln Thr Met Met Glu 
        195                 200                 205             


Asn Asp Gly Met Ser Trp Leu Phe Thr Leu Glu Asp Val His Ala Pro 
    210                 215                 220                 


Ser Val Tyr Leu Arg Leu Glu Ile Lys Glu Asp Asp Arg Pro Ser Phe 
225                 230                 235                 240 


Val Lys Gly Arg Val Ser Glu Ala Leu Arg Leu Ala Ala Lys Ser Ser 
                245                 250                 255     


Ser Lys Gln Arg Ile Leu Pro Tyr Tyr Trp Phe Ile Tyr Gln Asp Lys 
            260                 265                 270         


Lys Asp Glu Phe Leu Thr Glu Lys Asp Thr Gln Asn Thr Ile Asn Met 
        275                 280                 285             


Ile Ala Asn Leu Gly Ser Asn Gly Phe Ile Ile Trp Gly Ser Ser Asp 
    290                 295                 300                 


Asp Val Asn Thr Glu Arg Lys Cys Lys Asp Leu Gln Gln Tyr Val Lys 
305                 310                 315                 320 


Glu Val Leu Gly Pro Ala Ile Lys Lys Phe Thr Leu His His His His 
                325                 330                 335     


His His His 
            


<210>  6
<211>  29
<212>  DNA
<213>  ˹

<220>
<223>  ˹ϳ
<400>  6
ccggaattca tgaagacact acgcggctc                                         29


<210>  7
<211>  51
<212>  DNA
<213>  ˹

<220>
<223>  ˹ϳ

<400>  7
atttgcggcc gctcaatgat gatgatggtg gtgatgaagg gtgaacttct t                51


