                         SEQUENCE LISTING

<110>  TAKEDA PHARMACEUTICAL COMPANY LIMITED
 
<120>  COMPOSITION AND METHODS FOR THE TREATMENT OF FABRY DISEASE

<130>  MIL-014WO1

<150>  US63/154,485
<151>  2021-02-26

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  2
<211>  1881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
gatcttcaat attggccatt agccatatta ttcattggtt atatagcata aatcaatatt       60

ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta tattggctca      120

tgtccaatat gaccgccatg ttggcattga ttattgacta gttattaata gtaatcaatt      180

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat      240

ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt      300

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa      360

actgcccact tggcagtaca tcaagtgtat catatgccaa gtccgccccc tattgacgtc      420

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttacg ggactttcct      480

acttggcagt acatctacgt attagtcatc gctattacca tggtcgaggt gagccccacg      540

ttctgcttca ctctccccat ctcccccccc tccccacccc caattttgta tttatttatt      600

ttttaattat tttgtgcagc gatgggggcg gggggggggg gggggcgcgc gccaggcggg      660

gcggggcggg gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag      720

agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa      780

aagcgaagcg cgcggcgggc gggagtcgct gcgacgctgc cttcgccccg tgccccgctc      840

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      900

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt      960

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1020

ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg gagcgccgcg tgcggcccgc     1080

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1140

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1200

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcggcggt     1260

cgggctgtaa cccccccctg cacccccctc cccgagttgc tgagcacggc ccggcttcgg     1320

gtgcggggct ccgtacgggg cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc     1380

aggtgggggt gccgggcggg gcggggccgc ctcgggccgg ggagggctcg ggggaggggc     1440

gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc gagccgcagc cattgccttt     1500

tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc ccaaatctgt gcggagccga     1560

aatctgggag gcgccgccgc accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg     1620

gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc     1680

ctctccagcc tcggggctgt ccgcgggggg acggctgcct tcggggggga cggggcaggg     1740

cggggttcgg cttctggcgt gtgaccggcg gctctagagc ctctgctaac catgttcatg     1800

ccttcttctt tttcctacag ctcctgggca acgtgctggt tattgtgctg tctcatcatt     1860

ttggcaaaga attcgatatc a                                               1881


<210>  3
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggattggc aaggacgcct      120

accatgggct ggctgcactg ggagcgcttc atgtgcaacc ttgactgcca ggaagagcca      180

gattcctgca tcagtgagaa gctcttcatg gagatggcag agctcatggt ctcagaaggc      240

tggaaggatg caggttatga gtacctctgc attgatgact gttggatggc tccccaaaga      300

gattcagaag gcagacttca ggcagaccct cagcgctttc ctcatgggat tcgccagcta      360

gctaattatg ttcacagcaa aggactgaag ctagggattt atgcagatgt tggaaataaa      420

acctgcgcag gcttccctgg gagttttgga tactacgaca ttgatgccca gacctttgct      480

gactggggag tagatctgct aaaatttgat ggttgttact gtgacagttt ggaaaatttg      540

gcagatggtt ataagcacat gtccttggcc ctgaatagga ctggcagaag cattgtgtac      600

tcctgtgagt ggcctcttta tatgtggccc tttcaaaagc ccaattatac agaaatccga      660

cagtactgca atcactggcg aaattttgct gacattgatg attcctggaa aagtataaag      720

agtatcttgg actggacatc ttttaaccag gagagaattg ttgatgttgc tggaccaggg      780

ggttggaatg acccagatat gttagtgatt ggcaactttg gcctcagctg gaatcagcaa      840

gtaactcaga tggccctctg ggctatcatg gctgctcctt tattcatgtc taatgacctc      900

cgacacatca gccctcaagc caaagctctc cttcaggata aggacgtaat tgccatcaat      960

caggacccct tgggcaagca agggtaccag cttagacagg gagacaactt tgaagtgtgg     1020

gaacgacctc tctcaggctt agcctgggct gtagctatga taaaccggca ggagattggt     1080

ggacctcgct cttataccat cgcagttgct tccctgggta aaggagtggc ctgtaatcct     1140

gcctgcttca tcacacagct cctccctgtg aaaaggaagc tagggttcta tgaatggact     1200

tcaaggttaa gaagtcacat aaatcccaca ggcactgttt tgcttcagct agaaaataca     1260

atgcagatgt cattaaaaga cttactttaa                                      1290


<210>  4
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctttgttgct       60

ccttttacgc tttgtggata cgctgcttta ttgcctttgt atcttgctat tgcttcccgt      120

ttggctttca ttttctcctc cttgtataaa tcctggttgc tgtctctttt tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca tc              592


<210>  5
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
cctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc       60

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa      120

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg      180

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggaa            234


<210>  6
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag aga                                                         133


<210>  7
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Arg Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  8
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Leu Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  9
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Leu Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  10
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Leu Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Gly Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  11
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Leu Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Gly Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Lys Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  12
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val 
305                 310                 315                 320 


Ala Val Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Ala Val Ala Ser Leu Gly Gly Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Leu Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  13
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  14
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Arg Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Ser Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Asn Trp 
        355                 360                 365             


Thr Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  15
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  16
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  17
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala 
        355                 360                 365             


Thr Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  18
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
ctggataatg gattggctag aacacctact atggggtggc ttcactggga gaggttcatg       60

tgcaacctcg actgtcagga agaaccagac agctgcatct ccgagaagct gtttatggaa      120

atggccgagc gaatggtgtc agaaggctgg aaagatgcag gttacgagta tctgtgtatt      180

gacgattgct ggatggctcc gcaacgggac agtgagggca gacttcaggc agatcctcag      240

cgcttcccac atgggataag gcagctcgcc aactacgtcc actctaaggg actgaaactg      300

ggcatctatg ctgacgtggg gaataagacc tgtgcgggat ttcccggtag cttcggctac      360

tacgacattg atgcccagac ctttgccgat tggggagttg acctcctcaa attcgatggc      420

tgctattgtg actctttgga gaacctggca gacgggtaca agcatatgtc cctggccctg      480

aatcggacag gtagacccat cgtgtatagt tgcgaatggc ccctttacat gtggcctttt      540

caaaagccaa actacactga gattcgccag tattgcaatc actggaggaa cttcgctgat      600

atcgatgact catgggcgag catcaaatcc atattggatt ggacctctcg gaatcaggag      660

cgcattgtag acgtcgcagg acccggcggc tggaacgacc ctgatatgct ggtgatcggg      720

aattttggtc ttagctggga ccagcaagtt acgcagatgg ctctgtgggc aattatggca      780

gccccactct tcatgtccaa cgatctgcga cacatctctc ctcaagctaa ggctctgctg      840

caggacaaag atgtgattgc catcaatcag gacccactcg gaaagcaggg ctatcagctg      900

agaaaaggcg acaacttcga agtctgggaa aggccacttt caggagacgc atgggctgtg      960

gccataataa accggcaaga gattggtggg cccaggagct acacaatccc cgttgccagt     1020

ttgggcaagg gagtggcgtg taatcctgcc tgctttatca ctcagctgct cccagtcaaa     1080

agacagctgg ggttctatga gtggacctcc cgcctcaaga gccatattaa tcccacaggt     1140

accgtactgc tgcaacttga aaacacgatg cagatgagtt tgaaggacct cctgtag        1197


<210>  19
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
ctggataatg gattggctag aacacctcct atggggtggc ttcactggga gaggttcatg       60

tgcaacctgg actgtcagga agaaccagac agctgcatct ccgagaagct ctttgaggaa      120

atggccgaac gaatggtgac tgagggctgg aaagatgcag gttacgagta tctgtgtatt      180

gacgattgct ggatggcccc acaacgggat tctgagggaa gacttcaggc tgatccgcag      240

cgcttccctc atggcataag gcagctggca aaccacgtcc acagtaaggg gctcaaattg      300

ggaatctacg cggacgtggg caataagacc tgtgccggtt ttccgggatc attcgggtat      360

tatgacattg acgcccaaac gtttgctgat tggggcgttg acctgctgaa attcgatggt      420

tgctactgtg acagcctcga aaacctggca gacggctaca agcatatgtc tctcgccctg      480

aatagaaccg gtcggccaat cgtatattcc tgcgagtggc ctctttacat gtggccattt      540

cagaaaccga actacacaga aattcgccag tattgcaatc attggaggaa cttcgctgat      600

atcgatgact catgggcctc cataaagagc atcttggact ggaccagtcg gaatcaggag      660

cgaattgtgg atgtcgcagg ccctggagga tggaacgatc cagacatgct ggtgatcggc      720

aattttggcc tctcttggga ccagcaggtt acccaaatgg ctctgtgggc aattatggcc      780

ggtcctcttt tcatgagcaa cgatctgcgc gcgatctcac cacaggcaaa ggccctgctc      840

caagacaaag atgtgatagc catcaatcag gacccgttgg gaaagcaggg ctaccagctg      900

agaaaaggcg acaactttga ggtctgggaa aggcctttga gtggagatgc gtgggctgtg      960

gccattatta atcggcaaga gatcggaggt ccacgctcct atacaattcc tgtagcatct     1020

cttggcaagg gcgttgcctg taacccagct tgcttcatca ctcagcttct gccggtgaag     1080

agaaaactgg gtttctacga agctaccagc aggctccgat cccacatcaa ccctacagga     1140

accgtcctct tgcagctgga gaatacgatg cagacttcac tgaaggacct cctgtag        1197


<210>  20
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
ctggataatg gattggctag aacacctcct atggggtggc ttcactggga gaggttcatg       60

tgcaacctgg actgtcagga agaaccagac agctgcatct ccgagaagct ctttgaggaa      120

atggccgaac gaatggtgac tgagggctgg aaagatgcag gttacgagta tctgtgtatt      180

gacgattgct ggatggcccc acaacgggat tctgagggaa gacttcaggc tgatccgcag      240

cgcttccctc atggcataag gcagctggca aaccacgtcc acagtaaggg gctcaaattg      300

ggaatctacg cggacgtggg caataagacc tgtgccggtt ttccgggatc attcgggtat      360

tatgacattg acgcccaaac gtttgctgat tggggcgttg acctgctgaa attcgatggt      420

tgctactgtg acagcctcga aaacctggca gacggctaca agcatatgtc tctcgccctg      480

aataaaaccg gtcggccaat cgtatattcc tgcgagtggc ctctttacat gtggccattt      540

cagaaaccga actacacaga aattcgccag tattgcaatc attggaggaa cttcgctgat      600

atcgatgact catgggcctc cataaagagc atcttggact ggaccagtcg gaatcaggag      660

cgaattgtgg atgtcgcagg ccctggagga tggaacgatc cagacatgct ggtgatcggc      720

aattttggcc tctcttggga ccagcaggtt acccaaatgg ctctgtgggc aattatggcc      780

ggtcctcttt tcatgagcaa cgatctgcgc gcgatctcac cacaggcaaa ggccctgctc      840

caagacaaag atgtgatagc catcaatcag gacccgttgg gaaagcaggg ctaccagctg      900

agaaaaggcg acaactttga ggtctgggaa aggcctttga gtggagatgc gtgggctgtg      960

gccattatta atcggcaaga gatcggaggt ccacgctcct atacaattcc tgtagcatct     1020

cttggcaagg gcgttgcctg taacccagct tgcttcatca ctcagcttct gccggtgaag     1080

agaaaactgg gtttctacga agctaccagc aggctccgat cccacatcaa ccctacagga     1140

accgtcctct tgcagctgga gaatacgatg cagacttcac tgaaggacct cctgtag        1197


<210>  21
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
ctggataatg gattggctag aacacctcct atggggtggc ttcactggga gaggttcatg       60

tgcaacctgg actgtcagga agaaccagac agctgcatct ccgagaagct ctttgaggaa      120

atggccgaac gaatggtgac tgacggctgg aaagatgcag gttacgagta tctgtgtatt      180

gacgattgct ggatggcccc acaacgggat tctgagggaa gacttcaggc tgatccgcag      240

cgcttccctc atggcataag gcagctggca aaccacgtcc acagtaaggg gctcaaattg      300

ggaatctacg cggacgtggg caataagacc tgtgccggtt ttccgggatc attcgggtat      360

tatgacattg acgcccaaac gtttgctgat tggggcgttg acctgctgaa attcgatggt      420

tgctactgtg acagcctcga aaacctggca gacggctaca agcatatgtc tctcgccctg      480

aataaaaccg gtcggccaat cgtatattcc tgcgagtggc ctctttacat gtggccattt      540

cagaaaccga actacacaga aattcgccag tattgcaatc attggaggaa cttcgctgat      600

atcgatgact catgggcctc cataaagagc atcttggact ggaccagtcg gaatcaggag      660

cgaattgtgg atgtcgcagg ccctggagga tggaacgatc cagacatgct ggtgatcggc      720

aattttggcc tctcttggga ccagcaggtt acccaaatgg ctctgtgggc aattatggcc      780

ggtcctcttt tcatgagcaa cgatctgcgc gcgatctcac cacaggcaaa ggccctgctc      840

caagacaaag atgtgatagc catcaatcag gacccgttgg gaaagcaggg ctaccagctg      900

agaaaaggcg acaactttga ggtctgggaa aggcctttga gtggagatgc gtgggctgtg      960

gccattatta atcggcaaga gatcggaggt ccacgcggtt atacaattcc tgtagcatct     1020

cttggcaagg gcgttgcctg taacccagct tgcttcatca ctcagcttct gccggtgaag     1080

agaaaactgg gtttctacga agctaccagc aggctccgat cccacatcaa ccctacagga     1140

accgtcctct tgcagctgga gaatacgatg cagacttcac tgaaggacct cctgtag        1197


<210>  22
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
ctggataatg gattggctag aacacctcct atggggtggc ttcactggga gaggttcatg       60

tgcaacctgg actgtcagga agaaccagac agctgcatct ccgagaagct ctttgaggaa      120

atggccgaac gaatggtgac tgacggctgg aaagatgcag gttacgagta tctgtgtatt      180

gacgattgct ggatggcccc acaacgggat tctgagggaa gacttcaggc tgatccgcag      240

cgcttccctc atggcataag gcagctggca aaccacgtcc acagtaaggg gctcaaattg      300

ggaatctacg cggacgtggg caataagacc tgtgccggtt ttccgggatc attcgggtat      360

tatgacattg acgcccaaac gtttgctgat tggggcgttg acctgctgaa attcgatggt      420

tgctactgtg acagcctcga aaacctggca gacggctaca agcatatgtc tctcgccctg      480

aataaaaccg gtcggccaat cgtatattcc tgcgagtggc ctctttacat gtggccattt      540

cagaaaccga actacacaga aattcgccag tattgcaatc attggaggaa cttcgctgat      600

atcgatgact catgggcctc cataaagagc atcttggact ggaccagtcg gaatcaggag      660

cgaattgtgg atgtcgcagg ccctggagga tggaacgatc cagacatgct ggtgatcggc      720

aattttggcc tctcttggga ccagcaggtt acccaaatgg ctctgtgggc aattatggcc      780

ggtcctcttt tcatgagcaa cgatctgcgc gcgatctcac cacaggcaaa ggccctgctc      840

caagacaaag atgtgatagc catcaatcag gacccgttgg gaaagcaggg ctaccagctg      900

agaaaaggcg acaactttga ggtctgggaa aggcctttga gtggagatgc gtgggctgtg      960

gccattatta atcggcaaga gatcggaggt ccacgcggtt atacaattcc tgtagcaaag     1020

cttggcaagg gcgttgcctg taacccagct tgcttcatca ctcagcttct gccggtgaag     1080

agaaaactgg gtttctacga agctaccagc aggctccgat cccacatcaa ccctacagga     1140

accgtcctct tgcagctgga gaatacgatg cagacttcac tgaaggacct cctgtag        1197


<210>  23
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
ctggataatg gattggctag aacacctcct atggggtggc ttcactggga gaggttcatg       60

tgcaacctgg actgtcagga agaaccagac agctgcatct ccgagaagct ctttgaggaa      120

atggccgaac gaatggtgac tgacggctgg aaagatgcag gttacgagta tctgtgtatt      180

gacgattgct ggatggcccc acaacgggat tctgagggaa gacttcaggc tgatccgcag      240

cgcttccctc atggcataag gcagctggca aaccacgtcc acagtaaggg gctcaaattg      300

ggaatctacg cggacgtggg caataagacc tgtgccggtt ttccgggatc attcgggtat      360

tatgacattg acgcccaaac gtttgctgat tggggcgttg acctgctgaa attcgatggt      420

tgctactgtg acagcctcga aaacctggca gacggctaca agcatatgtc tctcgccctg      480

aataaaaccg gtcgggatat cgtatattcc tgcgagtggc ctctttacat gtggccattt      540

cagaaaccga actacacaga aattcgccag tattgcaatc attggaggaa cttcgctgat      600

atcgatgact catgggcctc cataaagagc atcttggact ggaccagtcg gaatcaggag      660

cgaattgtgg atgtcgcagg ccctggagga tggaacgatc cagacatgct ggtgatcggc      720

aattttggcc tctcttggga ccagcaggtt acccaaatgg ctctgtgggc aattatggcc      780

ggccctcttt tcatgagcaa cgatctgcgc gcgatctcac cacaggcaaa ggccctgctc      840

caagacacgg acgtgatagc catcaatcag gacccgttgg gaaagcaggg ctaccagctg      900

agaaaaggcg acaactttga ggtctgggaa aggcctttga gtggagatgc gtgggctgtg      960

gccattatta atcggcaaga gatcggaggt ccacgcggtt atacaattcc tgtagcaaag     1020

cttggcaagg gcgttgcctg taacccagct tgcttcatca ctcagcttct gccggtgaag     1080

agaaaactgg gtttctacga agctaccagc aggctccgat cccacatcaa ccctacagga     1140

accgtcctct tgcagctgga gaatacgatg cagacttcac tgaaggacct cctgtag        1197


<210>  24
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ttggacaatg ggctggccag gacacctact atgggctggc tccactggga gcgctttatg       60

tgtaacctcg actgccaaga ggagccagac tcatgcatct ctgagaagtt gttcatggag      120

atggctgagc tgatggtgag cgaagggtgg aaggatgcgg gctatgagta tctctgtatt      180

gatgactgct ggatggctcc acagcgcgac agtgaaggcc ggctccaggc cgatcctcag      240

cggttccccc acggtatcag acaactggcg aattacgtgc actcaaaagg ccttaagctg      300

ggtatatatg ctgatgtggg taataaaaca tgtgcaggct tcccaggctc ttttgggtac      360

tatgacatcg acgcccagac ttttgcggac tggggcgtgg acctgctcaa gtttgacgga      420

tgttactgtg actcccttga gaacctggcc gacgggtaca agcatatgtc actggccctg      480

aatcggacag gccgatccat cgtatactct tgcgagtggc ctctgtacat gtggcccttc      540

cagaagccca actatacaga aatcaggcaa tactgcaacc attggcggaa cttcgcagac      600

atagacgaca gctgggctag cattaagtct attctggatt ggaccagttt caatcaagaa      660

aggattgtcg atgtcgcagg cccaggaggt tggaatgacc cagacatgct cgtgattgga      720

aatttcggtc tgtcatggga ccaacaggtg actcagatgg ctctgtgggc aatcatggca      780

gcaccactgt tcatgagcaa tgatttgcga cacatctccc ctcaggcgaa agcccttctg      840

caggataagg acgttatcgc cattaaccag gacccgctcg gtaagcaagg gtaccagttg      900

cgccagggag acaatttcga ggtctgggaa cgacccctgt ctggactcgc ttgggccgta      960

gccgtaatta accgacaaga aatcggcgga ccgcggagct ataccatagc tgtcgcctcc     1020

ctcggcgggg gcgtagcttg taacccggct tgtttcataa cccagctgct gcccgtcaag     1080

aggaaactgg ggctttatga gtggacaagt cggttgaagt ctcatattaa cccgacaggg     1140

actgttctcc tccagctgga aaacacaatg cagatgagcc tgaaggatct cttgtga        1197


<210>  25
<211>  1198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
tttggacaat gggctggcca ggacacctac tatgggctgg ctccactggg agcgctttat       60

gtgtaacctc gactgccaag aggagccaga ctcatgcatc tctgagaagt tgttcatgga      120

aatggccgag cttatggtct cagaggggtg gaaagacgcc ggatatgagt atctgtgcat      180

cgacgattgc tggatggccc cccaacgcga ttccgaaggc cgcttgcagg ctgatccgca      240

gcgctttcct cacgggatcc gccaattggc aaattacgtg cactcaaagg ggctcaagtt      300

gggcatctac gcagacgtgg gaaacaagac atgtgctgga tttcccggga gtttcggtta      360

ttatgacatt gacgcacaga cctttgctga ttggggggtc gacctcctga agtttgacgg      420

ttgttattgc gacagccttg aaaatctggc cgacggttac aaacacatgt cccttgcact      480

gaatagaact ggtcggtcca tcgtctatag ttgtgagtgg ccgctttaca tgtggccttt      540

tcagaaaccc aactacaccg agattcggca atattgcaat cactggcgaa atttcgcaga      600

tatcgatgat tcttgggcta gtattaaatc catcctggat tggacatcat tcaaccagga      660

gcgcatcgtg gacgttgctg gacctggcgg gtggaatgat ccagacatgc ttgtgatcgg      720

aaacttcggt ctctcttgga accagcaagt cactcaaatg gcactctggg caattatggc      780

cgcccccctc tttatgtcca acgatctgag gcatatcagt cctcaggcta aagccctgct      840

gcaagacaag gatgtgattg ctatcaacca agatcccctt ggtaaacagg ggtaccagtt      900

gcgcaaaggc gacaattttg aggtgtggga aaggccactt tcaggcgatg catgggccgt      960

tgcaatgatc aacaggcaag aaattggcgg acccaggagc tatacaatac cagtggcgtc     1020

actgggtaag ggagtcgcct gtaaccccgc atgcttcatt actcaacttc tgccagtgaa     1080

acgaaaactc ggattctatg agtggacctc aagactgagg tctcatatta acccgacagg     1140

gactgttctc ctccagctgg aaaacacaat gcagatgagc ctgaaggatc tcttgtga       1198


<210>  26
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
ttggacaatg ggctggccag gacacctact atgggctggc tccactggga gcgctttatg       60

tgtaacctcg actgccaaga ggagccagac tcatgcatct ctgagaagtt gttcatggag      120

atggctgaac gcatggtttc tgagggatgg aaagatgcag gctacgagta cctgtgtata      180

gacgattgtt ggatggcccc acagcgggat tcagaaggta gactccaggc ggatccccag      240

agattcccac atggaatcag acagctggcc aattacgtcc attccaaagg ccttaagttg      300

ggtatttacg ccgacgtagg caacaagact tgtgccggat ttcccggcag tttcggatac      360

tatgacattg atgcacagac tttcgctgac tggggggtgg acttgctcaa atttgatggc      420

tgttattgcg atagcctcga aaatctggct gatggctaca agcacatgtc actcgctctc      480

aaccgcactg ggcgctctat agtttactcc tgcgagtggc ctctgtatat gtggccgttc      540

cagaaaccca attacacaga aataaggcag tattgcaatc actggcgcaa ctttgctgat      600

attgatgatt cctgggcctc cataaagagt atcttggact ggactagtcg caatcaggaa      660

agaattgtcg acgtcgccgg accaggcgga tggaatgatc ctgatatgct cgtgatcggg      720

aacttcggac tctcatggga ccagcaggtg acccagatgg ctagttgggc tatcatggcc      780

gcccctctgt ttatgagtaa cgacctccgc cacatcagcc cccaggccaa ggcgcttctg      840

caggataaag atgtcatcgc catcaaccaa gatcccctgg gcaaacaagg ctatcagctg      900

cggaagggag acaattttga ggtgtgggaa cgccctttga gcggagacgc ctgggctgtg      960

gctattataa atcgccagga gattgggggc ccgagaagtt atactatccc cgttgcaagc     1020

ctgggaaagg gcgtcgcctg caaccctgcc tgcttcatca cacagctgct tcctgtcaaa     1080

cgccaattgg ggttctacaa ttggacatcc agactcaaat ctcatattaa cccgacaggg     1140

actgttctcc tccagctgga aaacacaatg cagatgagcc tgaaggatct cttgtga        1197


<210>  27
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
ttggacaatg ggctggccag gacacctact atgggctggc tccactggga gcgctttatg       60

tgtaacctcg actgccaaga ggagccagac tcatgcatct ctgagaagtt gttcgaggag      120

atggcagaac gaatggtgac agatggatgg aaggacgctg gctacgagta tctgtgcata      180

gatgattgtt ggatggcccc tcagcgagac tcagagggga gactccaggc cgacccccag      240

cgatttccac acggaatccg gcaactggct aaccatgtgc actcaaaagg gctcaagctg      300

ggaatttatg ctgacgtcgg gaacaaaact tgtgcggggt ttcccggctc cttcggatat      360

tacgacatcg acgcccagac tttcgcagac tggggtgtgg acctgcttaa gttcgacggc      420

tgttactgcg atagtctgga aaacttggct gacggctata agcacatgag tctcgccctg      480

aaccgaacag gcagaagcat agtctactcc tgcgaatggc cactttacat gtggccattc      540

cagaaaccta attataccga gatcagacaa tactgtaacc attggcgaaa cttcgccgac      600

attgacgata gttggaagtc aatcaagtcc atcctggatt ggacctctag gaaccaggaa      660

aggatcgtgg acgtggctgg acctggcgga tggaacgatc cagacatgct cgtgatagga      720

aactttggac tgtcatggaa tcagcaagta acacagatgg cgctctgggc cattatggct      780

gcccccttgt ttatgtctaa cgacctgagg catatctctc ctcaagccaa ggcactcctg      840

caggacaagg acgttatcgc catcaaccag gacccactgg gcaagcaggg ataccagctg      900

cggaaaggtg ataacttcga ggtctgggag cgaccgcttt caggagacgc ctgggcagtt      960

gcaatcatca acaggcaaga aattggtggg ccacggtctt atactattcc cgtggcttct     1020

ctcggtaagg gcgtcgcctg caaccccgcc tgctttatca cccaattgtt gcccgttaag     1080

agaaaactgg gattttacga gtggacatcc aggctgcggt ctcatattaa cccgacaggg     1140

actgttctcc tccagctgga aaacacaatg cagatgagcc tgaaggatct cttgtga        1197


<210>  28
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ttggacaatg ggctggccag gacacctact atgggctggc tccactggga gcgctttatg       60

tgtaacctcg actgccaaga ggagccagac tcatgcatct ctgagaagtt gttcgaagag      120

atggctgaac tgatggtgtc cgaggggtgg aaggatgcag ggtacgagta cctttgcata      180

gacgattgct ggatggcacc acagcgggat agtgagggca ggttgcaggc ggacccccaa      240

agatttccac atggcatcag acagctggcc aaccacgtgc actctaaagg cctgaagctg      300

gggatttacg ccgatgtcgg taataaaaca tgtgctggtt tccccggtag ctttggatac      360

tacgacatcg acgcccagac atttgctgat tggggagtgg acctgctcaa gttcgacggc      420

tgctactgcg attctctgga aaatctggcc gatgggtata agcacatgag tcttgctctt      480

aatagaaccg gacgctctat agtctattca tgtgagtggc cactgtacat gtggccattt      540

cagaaaccca actataccga aattagacag tattgtaacc actggcggaa tttcgccgac      600

atagacgata gctggaagag catcaagtca attctcgatt ggacttcatt caaccaggag      660

cggatcgtcg acgtggccgg ccctgggggc tggaatgatc cagatatgct ggtgatcgga      720

aactttggtc tctcctggaa tcaacaggtc actcagatgg ccctctgggc cattatggca      780

gcaccactct ttatgagcaa cgacctgaga cacatttccc cacaggccaa ggcattgctg      840

caggacaaag acgtgatcgc cattaaccag gacccactgg gcaagcaagg gtaccaactt      900

aggcagggag ataattttga ggtctgggag cgcccactca gcggagacgc ctgggccgtt      960

gccatgataa acagacagga gattggcggc cccagatcct acacaattcc tgtcgctagc     1020

ctgggcaagg gggtggcttg taatcccgcc tgctttataa cccagctgct gccagtgaaa     1080

cggaaactcg ggttctatga atggacttct aggctcaggt ctcatattaa cccgacaggg     1140

actgttctcc tccagctgga aaacacaatg cagatgagcc tgaaggatct cttgtga        1197


<210>  29
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
ttggacaatg ggctggccag gacacctact atgggctggc tccactggga gcgctttatg       60

tgtaacctcg actgccaaga ggagccagac tcatgcatct ctgagaagtt gttcgaggag      120

atggcagaac gaatggtgac agatggatgg aaggacgctg gctacgagta tctgtgcata      180

gatgattgtt ggatggcccc tcagcgagac tcagagggga gactccaggc cgacccccag      240

cgatttccac acggaatccg gcaactggct aaccatgtgc actcaaaagg gctcaagctg      300

ggaatttatg ctgacgtcgg gaacaaaact tgtgcggggt ttcccggctc cttcggatat      360

tacgacatcg acgcccagac tttcgcagac tggggtgtgg acctgcttaa gttcgacggc      420

tgttactgcg atagtctgga aaacttggct gacggctata agcacatgag tctcgccctg      480

aaccgaacag gcagaagcat agtctactcc tgcgaatggc cactttacat gtggccattc      540

cagaaaccta attataccga gatcagacaa tactgtaacc attggcgaaa cttcgccgac      600

attgacgata gttggaagtc aatcaagtcc atcctggatt ggacctctag gaaccaggaa      660

aggatcgtgg acgtggctgg acctggcgga tggaacgatc cagacatgct cgtgatagga      720

aactttggac tgtcatggga tcagcaagta acacagatgg cgctctgggc cattatggct      780

gcccccttgt ttatgtctaa cgacctgagg catatctctc ctcaagccaa ggcactcctg      840

caggacaagg acgttatcgc catcaaccag gacccactgg gcaagcaggg ataccagctg      900

cggaaaggtg ataacttcga ggtctgggag cgaccgcttt caggagacgc ctgggcagtt      960

gcaatcatca acaggcaaga aattggtggg ccacggtctt atactattcc cgtggcttct     1020

ctcggtaagg gcgtcgcctg caaccccgcc tgctttatca cccaattgtt gcccgttaag     1080

agaaaactgg gattttacga ggcgacatcc aggctgaagt ctcatattaa cccgacaggg     1140

actgttctcc tccagctgga aaacacaatg cagatgagcc tgaaggatct cttgtga        1197


<210>  30
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val 
305                 310                 315                 320 


Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  31
<211>  1196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
tggacaatgg attggcaagg acgcctacca tgggctggct gcactgggag cgcttcatgt       60

gcaaccttga ctgccaggaa gagccagatt cctgcatcag tgagaagctc ttcgaggaga      120

tggcagagag aatggtcacc gacggctgga aggatgcagg ttatgagtac ctctgcattg      180

atgactgttg gatggctccc caaagagatt cagaaggcag acttcaggca gaccctcagc      240

gctttcctca tgggattcgc cagctagcta atcacgttca cagcaaagga ctgaagctag      300

ggatttatgc agatgttgga aataaaacct gcgcaggctt ccctgggagt tttggatact      360

acgacattga tgcccagacc tttgctgact ggggagtaga tctgctaaaa tttgatggtt      420

gttactgtga cagtttggaa aatttggcag atggttataa gcacatgtcc ttggccctga      480

ataggactgg cagaagcatt gtgtactcct gtgagtggcc tctttatatg tggccctttc      540

aaaagcccaa ttatacagaa atccgacagt actgcaatca ctggcgaaat tttgctgaca      600

ttgatgattc ctgggccagt ataaagagta tcttggactg gacatctaga aaccaggaga      660

gaattgttga tgttgctgga ccagggggtt ggaatgaccc agatatgtta gtgattggca      720

actttggcct cagctgggac cagcaagtaa ctcagatggc cctctgggct atcatggctg      780

ctcctttatt catgtctaat gacctccgac acatcagccc tcaagccaaa gctctccttc      840

aggataagga cgtaattgcc atcaatcagg accccttggg caagcaaggg taccagctta      900

gaaagggaga caactttgaa gtgtgggaac gacctctctc aggcgatgcc tgggctgtag      960

ctatcataaa ccggcaggag attggtggac ctcgctctta taccatcccc gttgcttccc     1020

tgggtaaagg agtggcctgt aatcctgcct gcttcatcac acagctcctc cctgtgaaaa     1080

ggcagctagg gttctataac tggacttcaa ggttaaagag tcacataaat cccacaggca     1140

ctgttttgct tcagctagaa aatacaatgc agatgtcatt aaaagactta ctttaa         1196


<210>  32
<211>  1196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
tggacaatgg attggcaagg acgcctccca tgggctggct gcactgggag cgcttcatgt       60

gcaaccttga ctgccaggaa gagccagatt cctgcatcag tgagaagctc ttcgaggaga      120

tggcagagag aatggtcacc gacggctgga aggatgcagg ttatgagtac ctctgcattg      180

atgactgttg gatggctccc caaagagatt cagaaggcag acttcaggca gaccctcagc      240

gctttcctca tgggattcgc cagctagcta atcacgttca cagcaaagga ctgaagctag      300

ggatttatgc agatgttgga aataaaacct gcgcaggctt ccctgggagt tttggatact      360

acgacattga tgcccagacc tttgctgact ggggagtaga tctgctaaaa tttgatggtt      420

gttactgtga cagtttggaa aatttggcag atggttataa gcacatgtcc ttggccctga      480

ataagactgg cagacccatt gtgtactcct gtgagtggcc tctttatatg tggccctttc      540

aaaagcccaa ttatacagaa atccgacagt actgcaatca ctggcgaaat tttgctgaca      600

ttgatgattc ctgggccagt ataaagagta tcttggactg gacatctaga aaccaggaga      660

gaattgttga tgttgctgga ccagggggtt ggaatgaccc agatatgtta gtgattggca      720

actttggcct cagctgggac cagcaagtaa ctcagatggc cctctgggct atcatggctg      780

ctcctttatt catgtctaat gacctccgac acatcagccc tcaagccaaa gctctccttc      840

aggataagga cgtaattgcc atcaatcagg accccttggg caagcaaggg taccagctta      900

gaaagggaga caactttgaa gtgtgggaac gacctctctc aggcgatgcc tgggctgtag      960

ctatcataaa ccggcaggag attggtggac ctcgctctta taccatcccc gttgcttccc     1020

tgggtaaagg agtggcctgt aatcctgcct gcttcatcac acagctcctc cctgtgaaaa     1080

ggcagctagg gttctataac tggacttcaa ggttaaagag tcacataaat cccacaggca     1140

ctgttttgct tcagctagaa aatacaatgc agatgtcatt aaaagactta ctttaa         1196


<210>  33
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Asn Trp 
        355                 360                 365             


Thr Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  34
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Leu Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Asn Trp 
        355                 360                 365             


Thr Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  35
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggactggc cagaactcct      120

cccatgggct ggctgcactg ggaaaggttt atgtgtaatc tggactgtca agaggagcca      180

gattcctgca tctctgagaa gctctttgaa gagatggctg agaggatggt gacagatggt      240

tggaaggatg ctggttatga gtacctgtgc attgatgact gctggatggc cccccagaga      300

gattcagaag gcagactgca agcagaccct cagaggttcc cccatggcat ccgccagctt      360

gccaaccatg tccactccaa gggcctgaaa ctgggtatct atgctgatgt gggcaataag      420

acctgtgctg gctttcctgg ctcctttggc tactatgaca ttgacgccca gacctttgct      480

gactggggtg tggacttgct gaagtttgat ggctgctact gtgactccct ggagaacctg      540

gcagatggat acaagcacat gtctctggct ctgaacaaga ctggcagacc cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca atcattggag gaactttgcc gacatcgatg attcttgggc ctccatcaag      720

agcatcctgg actggacatc cagaaaccaa gaaagaattg tggatgtggc tggacctgga      780

ggatggaatg atcctgacat gctggtgatt ggaaattttg ggctgtcctg ggaccagcaa      840

gtgactcaga tggccctctg ggccatcatg gctgggcccc tcttcatgag caatgacctg      900

agggccattt ccccccaagc caaggccctg cttcaagaca aagatgtcat tgctatcaat      960

caagatcccc tggggaagca aggctaccag ctcagaaaag gagacaactt cgaggtgtgg     1020

gagagacctc tgtctggaga tgcctgggct gtggccatca tcaacagaca agagattggt     1080

ggccccagag gttacaccat ccctgttgct tctcttggca agggtgttgc ctgcaaccca     1140

gcttgcttca tcacccagct gctcccagtg aagaggaagc tgggcttcta tgaagctacc     1200

tctaggttga gatcccacat caaccccact ggtactgtgc tgctgcagct ggaaaacacc     1260

atgcagactt ccctcaagga cctcctgtga                                      1290


<210>  36
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggacttgc aagaactcct      120

cccatgggct ggctgcactg ggagaggttt atgtgtaatc tggactgtca agaagaacca      180

gattcctgca tctctgagaa gctctttgag gagatggctg agaggatggt gacagatgga      240

tggaaggatg ctggttatga atatctgtgc attgatgact gctggatggc ccctcagaga      300

gacagtgaag gccgcctgca agcagacccc cagaggttcc cccatggaat cagacagttg      360

gccaaccatg tccactccaa gggcctgaaa ctgggcatct atgctgatgt gggcaataag      420

acctgtgctg gcttccctgg ctcctttggg tactatgaca ttgacgccca gacttttgct      480

gactggggtg tggacttgct gaagtttgat ggctgctact gtgactccct ggaaaacctg      540

gcagatggtt acaagcacat gtctctggcc ctgaacaaga ctggcagacc cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatccgc      660

cagtactgca atcattggag gaactttgca gacatcgatg attcttgggc cagcatcaag      720

tccatcctgg actggacttc cagaaaccaa gagagaattg tggatgttgc tggacctgga      780

ggttggaatg atcctgacat gctggtgatt ggaaattttg gactgtcctg ggaccagcaa      840

gtgactcaga tggccctctg ggccatcatg gctgggcccc tcttcatgag caatgacctg      900

agggccattt ccccccaagc caaggctctg cttcaagaca aagatgtcat tgctattaat      960

caagatcccc tggggaagca aggctaccag ctcagaaaag gagacaactt cgaggtgtgg     1020

gaaagacctc tgtctggaga tgcctgggct gtggctatca tcaacagaca agaaattggt     1080

ggccccagag gctacaccat ccctgtggcc tctcttggca agggtgttgc ctgcaaccca     1140

gcttgcttca tcacccagct gctcccagtg aagaggaagc tgggtttcta tgaggctacc     1200

tctaggttga gatcccacat caatcccact ggtacagtgc tgctgcagct ggagaacacc     1260

atgcagacct ccctcaagga cctcctttaa                                      1290


<210>  37
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atggactggc aagaactcct      120

cccatgggct ggctgcactg ggaaaggttt atgtgtaatc tggactgtca agaggagcca      180

gattcctgca tctctgagaa gctctttgaa gagatggctg agaggatggt gacagatgga      240

tggaaggatg ctggatatga gtacctgtgc attgatgact gctggatggc ccctcagaga      300

gacagtgaag gcagactgca agcagacccc cagaggttcc cccatggcat taggcagctg      360

gccaaccatg tccactccaa gggcctgaaa ctgggcatct atgctgatgt gggcaataag      420

acctgtgctg gtttccctgg ctcctttgga tactatgaca ttgatgccca gacctttgct      480

gactggggtg tggacctgct caagtttgat ggctgctact gtgactccct ggagaacctg      540

gctgatggtt acaagcacat gtctcttgct ctgaacaaga ctggtagacc cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca atcattggag gaattttgca gatattgatg attcttgggc ctccatcaag      720

agcatcctgg actggacttc cagaaaccaa gaaagaattg tggatgttgc tggccctgga      780

ggttggaatg accctgacat gctggtgatt ggcaactttg ggctgtcctg ggaccagcaa      840

gtgactcaga tggccctctg ggccatcatg gctgggcccc tcttcatgtc caatgatctg      900

agggccattt ccccccaagc caaggccctg cttcaagaca aagatgtcat tgctatcaat      960

caagatcccc tgggcaagca aggctaccag ctcagaaaag gagacaactt tgaggtgtgg     1020

gagagacctc tgtctggaga tgcctgggct gtggccatca tcaacagaca agagattggt     1080

ggccccagag gctacaccat ccctgtggct tccctgggga agggtgttgc ctgcaaccca     1140

gcttgcttca tcacccagct tctgccagtg aagaggaagc tgggcttcta tgaagctacc     1200

agcagactga gatcccacat caaccccact ggcacagtgc tgctgcagct ggaaaacacc     1260

atgcagactt ctctgaagga cctcctgtga                                      1290


<210>  38
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggactggc aagaactcct      120

cccatgggct ggctgcattg ggagaggttt atgtgtaatc tggactgtca agaggagcca      180

gactcctgca tctctgagaa gctctttgaa gagatggctg agaggatggt gacagatggt      240

tggaaggatg ctggatatga gtacctgtgc attgatgact gctggatggc cccccagaga      300

gacagtgaag gcagactgca agcagaccct cagaggttcc cccatggcat taggcagctg      360

gccaaccatg tccactccaa gggcctgaaa cttggcatct atgctgatgt gggcaataag      420

acctgtgctg gcttccctgg ctcctttggc tactatgaca ttgatgccca gacttttgct      480

gactggggtg tggacctgct caagtttgat ggctgctact gtgactctct ggaaaacctg      540

gctgatggat acaagcacat gtctttggct ctgaacaaga ctggtaggcc cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca accactggag gaactttgca gatattgatg attcctgggc ctccatcaag      720

agcatcctgg actggacttc cagaaaccaa gagagaattg tggatgttgc tgggcctgga      780

ggatggaatg atcctgacat gctggtgatt ggaaattttg ggctgagctg ggaccagcaa      840

gtgactcaga tggccctctg ggccatcatg gctggtcccc tcttcatgag caatgacttg      900

agggccattt ccccccaagc caaggccctg cttcaagaca aagatgtcat tgctatcaat      960

caagatcccc tgggcaagca aggctaccag ttgagaaaag gagacaactt tgaggtgtgg     1020

gaaagacctc tgtctggaga tgcctgggct gtggccatca tcaacagaca agaaattggt     1080

ggccccagag gttacaccat ccctgtggct tctcttggaa aaggggttgc ctgcaatcca     1140

gcttgcttca tcacccagct cctgccagtg aagaggaagc tgggtttcta tgaagctacc     1200

tctaggctca gatcccacat caaccccact ggcacagtgc tgctgcagct ggagaacacc     1260

atgcagacct ccctgaagga cctcctttaa                                      1290


<210>  39
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggactggc aagaactcct      120

cccatgggct ggctgcactg ggaaaggttt atgtgtaatc tggactgtca agaggagcct      180

gactcctgca tctctgagaa gctctttgaa gagatggctg agaggatggt gacagatgga      240

tggaaggatg ctggttatga gtacctgtgc attgatgact gctggatggc ccctcagaga      300

gattctgaag gcagactgca agcagacccc cagaggttcc cccatggcat taggcagctg      360

gccaaccatg tccactccaa gggcctgaaa ctgggcatct atgctgatgt gggcaataag      420

acctgtgctg gctttcctgg ctcctttgga tactatgaca ttgatgccca gacctttgct      480

gactggggtg tggacctcct gaagtttgat ggctgctact gtgactctct ggagaacctg      540

gctgatggtt acaagcacat gtctcttgct ctgaacaaga ctggtagacc cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca atcattggag gaattttgca gatattgatg attcctgggc ctccatcaag      720

agcatcctgg actggacatc cagaaaccaa gaaagaattg tggatgtggc tgggcctgga      780

ggttggaatg acccagacat gctggtgatt ggcaactttg ggctgagctg ggaccagcaa      840

gtgactcaga tggccctctg ggccatcatg gctggacctc tcttcatgtc caatgatctg      900

agagccattt ccccccaagc caaggccctg ctccaagaca aagatgtcat tgctatcaat      960

caagatcccc tggggaagca aggctaccag ctcagaaagg gtgacaactt tgaggtgtgg     1020

gagagacctc tgtctggaga tgcctgggct gtggccatca tcaacagaca agagattggt     1080

ggccccagag gctacaccat ccctgttgct tccctgggaa aaggagtggc ctgcaaccca     1140

gcttgcttca tcacccagct tctgcctgtg aagaggaagc tgggcttcta tgaagctacc     1200

tctaggctga ggtcccacat caaccccact ggcacagtgc tgctgcagct ggaaaacacc     1260

atgcagactt ccctcaagga cctgctttaa                                      1290


<210>  40
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggaca atggcctggc cagaacccct      120

cccatgggct ggctgcactg ggagagattc atgtgcaacc tggattgcca ggaggagcca      180

gactcttgca tctctgaaaa gctgtttgag gaaatggccg agagaatggt gacagatgga      240

tggaaggatg ccggatacga gtacctgtgt atcgatgact gttggatggc cccccagaga      300

gactccgagg gccgtctgca ggctgaccca cagaggtttc ctcatggaat taggcagttg      360

gccaaccatg tgcactccaa gggactgaag ctgggcatct atgccgatgt gggcaacaag      420

acctgtgctg gcttcccagg cagctttggc tattatgata ttgatgcaca aacttttgca      480

gactggggag ttgatctgct gaaatttgat gggtgttact gtgactccct ggagaacctc      540

gccgacggat acaagcatat gtcccttgct ctgaacaaga ctggcaggcc cattgtctac      600

tcttgtgagt ggccactgta catgtggccc ttccagaagc ccaactatac cgagattcgc      660

cagtactgca atcactggag gaactttgca gacattgatg acagctgggc ctccattaag      720

tctatcctgg attggacaag cagaaaccaa gagagaattg tggatgtggc tggccctggt      780

ggttggaatg accccgatat gctggtgatt ggcaactttg gactgtcttg ggaccagcag      840

gtgacccaga tggctctgtg ggctatcatg gccggccccc tcttcatgtc taatgacctg      900

agggccatct ctcctcaggc caaggcactt ctgcaggata aggacgtgat tgccatcaat      960

caggatcctc tggggaagca gggctatcag ctgagaaagg gggacaattt cgaggtctgg     1020

gagagacccc tgagcggcga tgcttgggct gtggccatca tcaatagaca agagattgga     1080

gggccaagag gctacaccat tcctgtggca agcctaggaa aaggggttgc ttgcaatcca     1140

gcctgtttca tcacccagct gctgcctgtt aagagaaagt tgggcttcta tgaggccacc     1200

tctaggctga ggtcccatat caaccccact ggcacagtgc tgctgcagct tgaaaacacc     1260

atgcagacct ccctcaagga cctgctgtaa                                      1290


<210>  41
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggactggc aagaacccca      120

accatgggct ggctgcactg ggaaagattc atgtgtaatc tggactgtca agaggagccc      180

gactcctgca tctctgagaa gctcttcatg gagatggctg agaggatggt gagtgaagga      240

tggaaggatg ctggttatga gtacctgtgc attgatgact gctggatggc cccccagaga      300

gattcagagg gcagactgca agcagatcct cagaggttcc cccatggcat cagacagctg      360

gccaactatg tccactccaa gggcctgaag ctgggtatct atgctgatgt gggcaacaag      420

acctgtgctg gctttcctgg ctcctttggt tactatgaca ttgacgccca gacctttgct      480

gactggggag tggacctgtt gaagtttgac ggctgctact gtgactctct ggagaacctg      540

gctgatggct acaagcacat gtctcttgcc ctgaacagaa ctggtaggag cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatccgc      660

cagtactgca accattggag gaactttgca gacatcgatg attcctgggc ctccatcaag      720

agcatcctgg actggacttc cagaaaccaa gagagaattg tggatgttgc tggacctgga      780

ggttggaatg accctgacat gctggtgatt ggaaattttg ggctgtcctg ggaccagcaa      840

gtgactcaga tggccagctg ggccatcatg gcagcccctc tctttatgtc caatgatctc      900

agacacattt ccccccaagc caaggctctg ctccaagaca aagatgtcat tgctattaat      960

caagatcccc tggggaagca aggctaccag ctgaggaaag gagacaactt tgaggtgtgg     1020

gagagacctc tgtctggaga tgcctgggct gtggctatca tcaatagaca agaaattggt     1080

ggccccagat cctacaccat ccctgtggct tccctgggca agggtgtggc ctgcaatcca     1140

gcttgcttca tcacccagct cctcccagtg aagaggcagc ttggcttcta caactggaca     1200

tctaggctca agtcccacat caaccccact ggcacagtgc tgctgcagct ggaaaacacc     1260

atgcagatga gcctgaaaga cctcctgtga                                      1290


<210>  42
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atggactggc taggacccca      120

accatgggtt ggctgcactg ggagaggttt atgtgtaatc tggactgtca agaagaacct      180

gactcctgca tctctgagaa gctgttcatg gagatggctg agaggatggt gagtgaaggc      240

tggaaggatg ctggttatga gtacctgtgc attgatgact gctggatggc ccctcagaga      300

gattcagagg gcagacttca agcagacccc cagaggttcc cccatggcat ccgccagctg      360

gccaactatg tccactccaa gggcctgaaa ctgggtatct atgctgatgt gggcaacaag      420

acctgtgctg gctttcctgg ctcctttggc tactatgaca ttgacgccca gacctttgct      480

gactggggtg tggacctcct caagtttgat ggctgctact gtgactctct ggaaaacctg      540

gcagatggtt acaagcacat gtctcttgcc ctgaacagaa ctggtaggag cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca accattggag gaattttgcc gacatcgatg attcctgggc cagcatcaag      720

tccatcctgg actggacttc cagaaaccaa gagagaattg tggatgttgc tggacctgga      780

ggatggaatg acccagacat gctggtgatt ggaaatttcg ggctgtcctg ggaccagcaa      840

gtgactcaga tggcctcttg ggccatcatg gcagcccccc tcttcatgtc caatgatctt      900

agacacattt ccccacaagc caaggccctc ctgcaagaca aagatgtcat tgctattaat      960

caagatcccc tggggaagca aggctaccag ctcagaaaag gagacaactt tgaggtgtgg     1020

gaaagacctc tgtctggaga tgcctgggct gtggctatca tcaatagaca agaaattggt     1080

ggccccagat cctacaccat ccctgtggcc tccctgggca agggtgttgc ctgcaatcca     1140

gcttgcttca tcacccagct gctcccagtg aagaggcagt tgggcttcta caactggaca     1200

tctaggttga agagccacat caaccccact ggcacagtgc tgctgcagct ggagaacacc     1260

atgcagatga gcctgaagga cctgctttaa                                      1290


<210>  43
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggactggc aagaacccca      120

accatgggtt ggctgcactg ggagaggttt atgtgtaatc tggactgtca agaggagcca      180

gactcctgca tctctgagaa gctcttcatg gagatggctg agaggatggt gagtgaaggc      240

tggaaggatg ctggttatga gtacctgtgc attgatgact gctggatggc ccctcagaga      300

gattcagagg gcagactgca agcagatccc cagaggttcc cccatggcat taggcaactg      360

gccaactatg tccactccaa gggcctgaag ctgggcatct atgctgatgt gggcaacaag      420

acctgtgctg gcttccctgg ctcctttggc tactatgata ttgatgccca gacctttgct      480

gactggggtg tggacctgct caagtttgat ggctgctact gtgacagcct ggagaacctg      540

gctgatggtt acaagcacat gtctcttgct ctgaacagaa ctggtagaag cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca accattggag gaactttgca gacattgatg attcctgggc ctccatcaag      720

agcatcctgg actggacttc cagaaaccaa gagagaattg tggatgttgc tggacctgga      780

ggatggaatg accctgacat gctggtgatt ggaaattttg ggctgtcctg ggaccagcaa      840

gtgactcaga tggccagctg ggccatcatg gcagcccccc tgttcatgag caatgatctc      900

agacacattt ccccccaagc caaggccctg cttcaagaca aagatgtcat tgctattaat      960

caagatcctt tgggcaagca aggctaccag ctgaggaagg gagacaactt tgaggtgtgg     1020

gaaagacctc tgtctggaga tgcctgggct gtggctatca tcaatagaca agaaattggt     1080

ggccccagat cctacaccat ccctgttgcc tctctgggaa aaggagtggc ctgcaatcca     1140

gcttgcttca tcacccagct cctcccagtg aagaggcagc tgggtttcta caactggaca     1200

agcagattga agtcccacat caaccccact ggcacagtgc tgctgcagct ggaaaacacc     1260

atgcagatgt ccctgaagga cctcctgtga                                      1290


<210>  44
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcacttgata atggactggc aagaacccca      120

accatgggct ggctgcactg ggaaagattc atgtgtaatc tggactgtca agaagaacca      180

gattcctgca tctctgagaa gctgtttatg gagatggctg agaggatggt gtcagaagga      240

tggaaggatg ctggttatga gtacctgtgc attgatgact gctggatggc cccccagaga      300

gacagtgaag gcagacttca agcagaccct cagaggttcc cccatggcat taggcaacta      360

gccaactatg tccactccaa gggcctgaaa ctgggcatct atgctgatgt gggcaacaag      420

acctgtgctg gcttccctgg ctcctttggc tactatgaca ttgatgccca gacctttgct      480

gactggggtg tggacctcct caagtttgat ggctgctact gtgactccct ggaaaacctg      540

gctgatggtt acaagcacat gagcctggcc ctgaacagaa ctggtaggag cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca accattggag gaactttgca gatattgatg attcttgggc cagcatcaag      720

tccatcctgg actggacatc cagaaaccaa gagagaattg tggatgttgc tggacctgga      780

ggttggaatg atcctgacat gctggtgatt ggaaattttg ggctgtcctg ggaccagcaa      840

gtgactcaga tggcctcctg ggccatcatg gcagcccctc tcttcatgtc caatgacttg      900

agacacattt ccccccaagc caaggccctc ctgcaagaca aagatgtcat tgctattaat      960

caagatccct tgggcaagca aggctaccag ctgaggaagg gagacaactt tgaggtgtgg     1020

gagaggcccc tgtctggaga tgcctgggct gtggctatca tcaatagaca agaaattggt     1080

ggccccagat cctacaccat ccctgttgcc tctcttggca aaggagtggc ctgcaatcca     1140

gcttgcttca tcacccagct ccttcctgtg aagaggcagc tgggtttcta caactggact     1200

tcaaggttga agagccacat caaccccact ggcacagtgc tgctgcagct ggagaacacc     1260

atgcagatgt ctctgaagga cctgctttaa                                      1290


<210>  45
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggactggc aagaacccca      120

accatgggct ggctgcactg ggagaggttc atgtgtaatc tggactgtca agaggagcct      180

gactcctgca tctctgagaa gctgtttatg gagatggctg agaggatggt gtctgaagga      240

tggaaggatg ctggctatga gtacctgtgc attgatgact gctggatggc ccctcagagg      300

gacagtgaag gcagactgca agcagacccc cagagattcc cccatggcat tagacagctt      360

gccaactatg tccactccaa gggcctgaaa ctgggcatct atgctgatgt gggcaacaag      420

acctgtgctg gtttccctgg ctcctttggc tactatgaca ttgatgccca gacctttgct      480

gactggggtg tggacctcct caagtttgat ggctgctact gtgacagcct ggaaaacctg      540

gctgatggtt acaagcacat gtctctggcc ctgaacagaa ctggtaggag cattgtttac      600

agctgtgagt ggccactgta catgtggccc ttccagaagc ccaactacac tgagatcaga      660

cagtactgca accattggag gaactttgca gatattgatg attcctgggc ctccatcaag      720

agcatcctgg actggacttc cagaaaccaa gagagaattg tggatgtagc tggacctgga      780

ggttggaatg acccagacat gctggtgatt ggaaattttg ggctgtcctg ggaccagcaa      840

gtgactcaga tggccagctg ggccatcatg gcagcccccc tcttcatgag caatgatctc      900

agacacattt ccccccaagc caaggctctg ctccaagaca aagatgtcat tgctattaat      960

caagatcccc tggggaagca aggctaccag ctgaggaagg gagacaactt tgaggtgtgg     1020

gaaagacctc tgtctggaga tgcctgggct gtggctatca tcaatagaca agaaattggt     1080

ggccccagat cctacaccat ccctgttgct tctcttggca aaggagtggc ctgcaatcca     1140

gcttgcttca tcacccagct cctgcctgtg aagaggcagt tgggcttcta caactggaca     1200

tctaggttga agtcccacat caaccccact ggcacagtgc tgctgcagct ggagaacacc     1260

atgcagatgt ccctgaagga cctgctttaa                                      1290


<210>  46
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Leu Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Arg Asp Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Thr Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val 
305                 310                 315                 320 


Ala Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Gly Tyr Thr Ile 
                325                 330                 335     


Pro Val Ala Lys Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  47
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Arg Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  48
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  49
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  50
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Gly Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  51
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Gly Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Lys Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  52
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Lys Thr Gly Arg Asp Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Gly Pro Leu Phe Met Ser Asn Asp Leu Arg Ala Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Thr Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Gly Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Lys Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Thr Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  53
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Val Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Gly Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Leu Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  54
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  55
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Arg Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Ser Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Asn Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  56
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  57
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  58
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Ala Thr 
385                 390                 395                 400 


Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  59
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Asn Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  60
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Pro Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Glu Glu Met Ala Glu Arg Met Val Thr Asp Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn His Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Lys Thr Gly Arg Pro Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Ala Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Arg Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asp Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Lys Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Asp Ala Trp Ala Val Ala 
            340                 345                 350         


Ile Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Pro 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Gln Leu Gly Phe Tyr Asn Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Lys Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  61
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggattggc tagaacacct      120

actatggggt ggcttcactg ggagaggttc atgtgcaacc tcgactgtca ggaagaacca      180

gacagctgca tctccgagaa gctgtttatg gaaatggccg agcgaatggt gtcagaaggc      240

tggaaagatg caggttacga gtatctgtgt attgacgatt gctggatggc tccgcaacgg      300

gacagtgagg gcagacttca ggcagatcct cagcgcttcc cacatgggat aaggcagctc      360

gccaactacg tccactctaa gggactgaaa ctgggcatct atgctgacgt ggggaataag      420

acctgtgcgg gatttcccgg tagcttcggc tactacgaca ttgatgccca gacctttgcc      480

gattggggag ttgacctcct caaattcgat ggctgctatt gtgactcttt ggagaacctg      540

gcagacgggt acaagcatat gtccctggcc ctgaatcgga caggtagacc catcgtgtat      600

agttgcgaat ggccccttta catgtggcct tttcaaaagc caaactacac tgagattcgc      660

cagtattgca atcactggag gaacttcgct gatatcgatg actcatgggc gagcatcaaa      720

tccatattgg attggacctc tcggaatcag gagcgcattg tagacgtcgc aggacccggc      780

ggctggaacg accctgatat gctggtgatc gggaattttg gtcttagctg ggaccagcaa      840

gttacgcaga tggctctgtg ggcaattatg gcagccccac tcttcatgtc caacgatctg      900

cgacacatct ctcctcaagc taaggctctg ctgcaggaca aagatgtgat tgccatcaat      960

caggacccac tcggaaagca gggctatcag ctgagaaaag gcgacaactt cgaagtctgg     1020

gaaaggccac tttcaggaga cgcatgggct gtggccataa taaaccggca agagattggt     1080

gggcccagga gctacacaat ccccgttgcc agtttgggca agggagtggc gtgtaatcct     1140

gcctgcttta tcactcagct gctcccagtc aaaagacagc tggggttcta tgagtggacc     1200

tcccgcctca agagccatat taatcccaca ggtaccgtac tgctgcaact tgaaaacacg     1260

atgcagatga gtttgaagga cctcctgtag                                      1290


<210>  62
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggattggc tagaacacct      120

cctatggggt ggcttcactg ggagaggttc atgtgcaacc tggactgtca ggaagaacca      180

gacagctgca tctccgagaa gctctttgag gaaatggccg aacgaatggt gactgagggc      240

tggaaagatg caggttacga gtatctgtgt attgacgatt gctggatggc cccacaacgg      300

gattctgagg gaagacttca ggctgatccg cagcgcttcc ctcatggcat aaggcagctg      360

gcaaaccacg tccacagtaa ggggctcaaa ttgggaatct acgcggacgt gggcaataag      420

acctgtgccg gttttccggg atcattcggg tattatgaca ttgacgccca aacgtttgct      480

gattggggcg ttgacctgct gaaattcgat ggttgctact gtgacagcct cgaaaacctg      540

gcagacggct acaagcatat gtctctcgcc ctgaatagaa ccggtcggcc aatcgtatat      600

tcctgcgagt ggcctcttta catgtggcca tttcagaaac cgaactacac agaaattcgc      660

cagtattgca atcattggag gaacttcgct gatatcgatg actcatgggc ctccataaag      720

agcatcttgg actggaccag tcggaatcag gagcgaattg tggatgtcgc aggccctgga      780

ggatggaacg atccagacat gctggtgatc ggcaattttg gcctctcttg ggaccagcag      840

gttacccaaa tggctctgtg ggcaattatg gccggtcctc ttttcatgag caacgatctg      900

cgcgcgatct caccacaggc aaaggccctg ctccaagaca aagatgtgat agccatcaat      960

caggacccgt tgggaaagca gggctaccag ctgagaaaag gcgacaactt tgaggtctgg     1020

gaaaggcctt tgagtggaga tgcgtgggct gtggccatta ttaatcggca agagatcgga     1080

ggtccacgct cctatacaat tcctgtagca tctcttggca agggcgttgc ctgtaaccca     1140

gcttgcttca tcactcagct tctgccggtg aagagaaaac tgggtttcta cgaagctacc     1200

agcaggctcc gatcccacat caaccctaca ggaaccgtcc tcttgcagct ggagaatacg     1260

atgcagactt cactgaagga cctcctgtag                                      1290


<210>  63
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggattggc tagaacacct      120

cctatggggt ggcttcactg ggagaggttc atgtgcaacc tggactgtca ggaagaacca      180

gacagctgca tctccgagaa gctctttgag gaaatggccg aacgaatggt gactgagggc      240

tggaaagatg caggttacga gtatctgtgt attgacgatt gctggatggc cccacaacgg      300

gattctgagg gaagacttca ggctgatccg cagcgcttcc ctcatggcat aaggcagctg      360

gcaaaccacg tccacagtaa ggggctcaaa ttgggaatct acgcggacgt gggcaataag      420

acctgtgccg gttttccggg atcattcggg tattatgaca ttgacgccca aacgtttgct      480

gattggggcg ttgacctgct gaaattcgat ggttgctact gtgacagcct cgaaaacctg      540

gcagacggct acaagcatat gtctctcgcc ctgaataaaa ccggtcggcc aatcgtatat      600

tcctgcgagt ggcctcttta catgtggcca tttcagaaac cgaactacac agaaattcgc      660

cagtattgca atcattggag gaacttcgct gatatcgatg actcatgggc ctccataaag      720

agcatcttgg actggaccag tcggaatcag gagcgaattg tggatgtcgc aggccctgga      780

ggatggaacg atccagacat gctggtgatc ggcaattttg gcctctcttg ggaccagcag      840

gttacccaaa tggctctgtg ggcaattatg gccggtcctc ttttcatgag caacgatctg      900

cgcgcgatct caccacaggc aaaggccctg ctccaagaca aagatgtgat agccatcaat      960

caggacccgt tgggaaagca gggctaccag ctgagaaaag gcgacaactt tgaggtctgg     1020

gaaaggcctt tgagtggaga tgcgtgggct gtggccatta ttaatcggca agagatcgga     1080

ggtccacgct cctatacaat tcctgtagca tctcttggca agggcgttgc ctgtaaccca     1140

gcttgcttca tcactcagct tctgccggtg aagagaaaac tgggtttcta cgaagctacc     1200

agcaggctcc gatcccacat caaccctaca ggaaccgtcc tcttgcagct ggagaatacg     1260

atgcagactt cactgaagga cctcctgtag                                      1290


<210>  64
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggattggc tagaacacct      120

cctatggggt ggcttcactg ggagaggttc atgtgcaacc tggactgtca ggaagaacca      180

gacagctgca tctccgagaa gctctttgag gaaatggccg aacgaatggt gactgacggc      240

tggaaagatg caggttacga gtatctgtgt attgacgatt gctggatggc cccacaacgg      300

gattctgagg gaagacttca ggctgatccg cagcgcttcc ctcatggcat aaggcagctg      360

gcaaaccacg tccacagtaa ggggctcaaa ttgggaatct acgcggacgt gggcaataag      420

acctgtgccg gttttccggg atcattcggg tattatgaca ttgacgccca aacgtttgct      480

gattggggcg ttgacctgct gaaattcgat ggttgctact gtgacagcct cgaaaacctg      540

gcagacggct acaagcatat gtctctcgcc ctgaataaaa ccggtcggcc aatcgtatat      600

tcctgcgagt ggcctcttta catgtggcca tttcagaaac cgaactacac agaaattcgc      660

cagtattgca atcattggag gaacttcgct gatatcgatg actcatgggc ctccataaag      720

agcatcttgg actggaccag tcggaatcag gagcgaattg tggatgtcgc aggccctgga      780

ggatggaacg atccagacat gctggtgatc ggcaattttg gcctctcttg ggaccagcag      840

gttacccaaa tggctctgtg ggcaattatg gccggtcctc ttttcatgag caacgatctg      900

cgcgcgatct caccacaggc aaaggccctg ctccaagaca aagatgtgat agccatcaat      960

caggacccgt tgggaaagca gggctaccag ctgagaaaag gcgacaactt tgaggtctgg     1020

gaaaggcctt tgagtggaga tgcgtgggct gtggccatta ttaatcggca agagatcgga     1080

ggtccacgcg gttatacaat tcctgtagca tctcttggca agggcgttgc ctgtaaccca     1140

gcttgcttca tcactcagct tctgccggtg aagagaaaac tgggtttcta cgaagctacc     1200

agcaggctcc gatcccacat caaccctaca ggaaccgtcc tcttgcagct ggagaatacg     1260

atgcagactt cactgaagga cctcctgtag                                      1290


<210>  65
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggattggc tagaacacct      120

cctatggggt ggcttcactg ggagaggttc atgtgcaacc tggactgtca ggaagaacca      180

gacagctgca tctccgagaa gctctttgag gaaatggccg aacgaatggt gactgacggc      240

tggaaagatg caggttacga gtatctgtgt attgacgatt gctggatggc cccacaacgg      300

gattctgagg gaagacttca ggctgatccg cagcgcttcc ctcatggcat aaggcagctg      360

gcaaaccacg tccacagtaa ggggctcaaa ttgggaatct acgcggacgt gggcaataag      420

acctgtgccg gttttccggg atcattcggg tattatgaca ttgacgccca aacgtttgct      480

gattggggcg ttgacctgct gaaattcgat ggttgctact gtgacagcct cgaaaacctg      540

gcagacggct acaagcatat gtctctcgcc ctgaataaaa ccggtcggcc aatcgtatat      600

tcctgcgagt ggcctcttta catgtggcca tttcagaaac cgaactacac agaaattcgc      660

cagtattgca atcattggag gaacttcgct gatatcgatg actcatgggc ctccataaag      720

agcatcttgg actggaccag tcggaatcag gagcgaattg tggatgtcgc aggccctgga      780

ggatggaacg atccagacat gctggtgatc ggcaattttg gcctctcttg ggaccagcag      840

gttacccaaa tggctctgtg ggcaattatg gccggtcctc ttttcatgag caacgatctg      900

cgcgcgatct caccacaggc aaaggccctg ctccaagaca aagatgtgat agccatcaat      960

caggacccgt tgggaaagca gggctaccag ctgagaaaag gcgacaactt tgaggtctgg     1020

gaaaggcctt tgagtggaga tgcgtgggct gtggccatta ttaatcggca agagatcgga     1080

ggtccacgcg gttatacaat tcctgtagca aagcttggca agggcgttgc ctgtaaccca     1140

gcttgcttca tcactcagct tctgccggtg aagagaaaac tgggtttcta cgaagctacc     1200

agcaggctcc gatcccacat caaccctaca ggaaccgtcc tcttgcagct ggagaatacg     1260

atgcagactt cactgaagga cctcctgtag                                      1290


<210>  66
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcactggata atggattggc tagaacacct      120

cctatggggt ggcttcactg ggagaggttc atgtgcaacc tggactgtca ggaagaacca      180

gacagctgca tctccgagaa gctctttgag gaaatggccg aacgaatggt gactgacggc      240

tggaaagatg caggttacga gtatctgtgt attgacgatt gctggatggc cccacaacgg      300

gattctgagg gaagacttca ggctgatccg cagcgcttcc ctcatggcat aaggcagctg      360

gcaaaccacg tccacagtaa ggggctcaaa ttgggaatct acgcggacgt gggcaataag      420

acctgtgccg gttttccggg atcattcggg tattatgaca ttgacgccca aacgtttgct      480

gattggggcg ttgacctgct gaaattcgat ggttgctact gtgacagcct cgaaaacctg      540

gcagacggct acaagcatat gtctctcgcc ctgaataaaa ccggtcggga tatcgtatat      600

tcctgcgagt ggcctcttta catgtggcca tttcagaaac cgaactacac agaaattcgc      660

cagtattgca atcattggag gaacttcgct gatatcgatg actcatgggc ctccataaag      720

agcatcttgg actggaccag tcggaatcag gagcgaattg tggatgtcgc aggccctgga      780

ggatggaacg atccagacat gctggtgatc ggcaattttg gcctctcttg ggaccagcag      840

gttacccaaa tggctctgtg ggcaattatg gccggccctc ttttcatgag caacgatctg      900

cgcgcgatct caccacaggc aaaggccctg ctccaagaca cggacgtgat agccatcaat      960

caggacccgt tgggaaagca gggctaccag ctgagaaaag gcgacaactt tgaggtctgg     1020

gaaaggcctt tgagtggaga tgcgtgggct gtggccatta ttaatcggca agagatcgga     1080

ggtccacgcg gttatacaat tcctgtagca aagcttggca agggcgttgc ctgtaaccca     1140

gcttgcttca tcactcagct tctgccggtg aagagaaaac tgggtttcta cgaagctacc     1200

agcaggctcc gatcccacat caaccctaca ggaaccgtcc tcttgcagct ggagaatacg     1260

atgcagactt cactgaagga cctcctgtag                                      1290


<210>  67
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atgggctggc caggacacct      120

actatgggct ggctccactg ggagcgcttt atgtgtaacc tcgactgcca agaggagcca      180

gactcatgca tctctgagaa gttgttcatg gagatggctg agctgatggt gagcgaaggg      240

tggaaggatg cgggctatga gtatctctgt attgatgact gctggatggc tccacagcgc      300

gacagtgaag gccggctcca ggccgatcct cagcggttcc cccacggtat cagacaactg      360

gcgaattacg tgcactcaaa aggccttaag ctgggtatat atgctgatgt gggtaataaa      420

acatgtgcag gcttcccagg ctcttttggg tactatgaca tcgacgccca gacttttgcg      480

gactggggcg tggacctgct caagtttgac ggatgttact gtgactccct tgagaacctg      540

gccgacgggt acaagcatat gtcactggcc ctgaatcgga caggccgatc catcgtatac      600

tcttgcgagt ggcctctgta catgtggccc ttccagaagc ccaactatac agaaatcagg      660

caatactgca accattggcg gaacttcgca gacatagacg acagctgggc tagcattaag      720

tctattctgg attggaccag tttcaatcaa gaaaggattg tcgatgtcgc aggcccagga      780

ggttggaatg acccagacat gctcgtgatt ggaaatttcg gtctgtcatg ggaccaacag      840

gtgactcaga tggctctgtg ggcaatcatg gcagcaccac tgttcatgag caatgatttg      900

cgacacatct cccctcaggc gaaagccctt ctgcaggata aggacgttat cgccattaac      960

caggacccgc tcggtaagca agggtaccag ttgcgccagg gagacaattt cgaggtctgg     1020

gaacgacccc tgtctggact cgcttgggcc gtagccgtaa ttaaccgaca agaaatcggc     1080

ggaccgcgga gctataccat agctgtcgcc tccctcggcg ggggcgtagc ttgtaacccg     1140

gcttgtttca taacccagct gctgcccgtc aagaggaaac tggggcttta tgagtggaca     1200

agtcggttga agtctcatat taacccgaca gggactgttc tcctccagct ggaaaacaca     1260

atgcagatga gcctgaagga tctcttgtga                                      1290


<210>  68
<211>  1291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcatttggac aatgggctgg ccaggacacc      120

tactatgggc tggctccact gggagcgctt tatgtgtaac ctcgactgcc aagaggagcc      180

agactcatgc atctctgaga agttgttcat ggaaatggcc gagcttatgg tctcagaggg      240

gtggaaagac gccggatatg agtatctgtg catcgacgat tgctggatgg ccccccaacg      300

cgattccgaa ggccgcttgc aggctgatcc gcagcgcttt cctcacggga tccgccaatt      360

ggcaaattac gtgcactcaa aggggctcaa gttgggcatc tacgcagacg tgggaaacaa      420

gacatgtgct ggatttcccg ggagtttcgg ttattatgac attgacgcac agacctttgc      480

tgattggggg gtcgacctcc tgaagtttga cggttgttat tgcgacagcc ttgaaaatct      540

ggccgacggt tacaaacaca tgtcccttgc actgaataga actggtcggt ccatcgtcta      600

tagttgtgag tggccgcttt acatgtggcc ttttcagaaa cccaactaca ccgagattcg      660

gcaatattgc aatcactggc gaaatttcgc agatatcgat gattcttggg ctagtattaa      720

atccatcctg gattggacat cattcaacca ggagcgcatc gtggacgttg ctggacctgg      780

cgggtggaat gatccagaca tgcttgtgat cggaaacttc ggtctctctt ggaaccagca      840

agtcactcaa atggcactct gggcaattat ggccgccccc ctctttatgt ccaacgatct      900

gaggcatatc agtcctcagg ctaaagccct gctgcaagac aaggatgtga ttgctatcaa      960

ccaagatccc cttggtaaac aggggtacca gttgcgcaaa ggcgacaatt ttgaggtgtg     1020

ggaaaggcca ctttcaggcg atgcatgggc cgttgcaatg atcaacaggc aagaaattgg     1080

cggacccagg agctatacaa taccagtggc gtcactgggt aagggagtcg cctgtaaccc     1140

cgcatgcttc attactcaac ttctgccagt gaaacgaaaa ctcggattct atgagtggac     1200

ctcaagactg aggtctcata ttaacccgac agggactgtt ctcctccagc tggaaaacac     1260

aatgcagatg agcctgaagg atctcttgtg a                                    1291


<210>  69
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atgggctggc caggacacct      120

actatgggct ggctccactg ggagcgcttt atgtgtaacc tcgactgcca agaggagcca      180

gactcatgca tctctgagaa gttgttcatg gagatggctg aacgcatggt ttctgaggga      240

tggaaagatg caggctacga gtacctgtgt atagacgatt gttggatggc cccacagcgg      300

gattcagaag gtagactcca ggcggatccc cagagattcc cacatggaat cagacagctg      360

gccaattacg tccattccaa aggccttaag ttgggtattt acgccgacgt aggcaacaag      420

acttgtgccg gatttcccgg cagtttcgga tactatgaca ttgatgcaca gactttcgct      480

gactgggggg tggacttgct caaatttgat ggctgttatt gcgatagcct cgaaaatctg      540

gctgatggct acaagcacat gtcactcgct ctcaaccgca ctgggcgctc tatagtttac      600

tcctgcgagt ggcctctgta tatgtggccg ttccagaaac ccaattacac agaaataagg      660

cagtattgca atcactggcg caactttgct gatattgatg attcctgggc ctccataaag      720

agtatcttgg actggactag tcgcaatcag gaaagaattg tcgacgtcgc cggaccaggc      780

ggatggaatg atcctgatat gctcgtgatc gggaacttcg gactctcatg ggaccagcag      840

gtgacccaga tggctagttg ggctatcatg gccgcccctc tgtttatgag taacgacctc      900

cgccacatca gcccccaggc caaggcgctt ctgcaggata aagatgtcat cgccatcaac      960

caagatcccc tgggcaaaca aggctatcag ctgcggaagg gagacaattt tgaggtgtgg     1020

gaacgccctt tgagcggaga cgcctgggct gtggctatta taaatcgcca ggagattggg     1080

ggcccgagaa gttatactat ccccgttgca agcctgggaa agggcgtcgc ctgcaaccct     1140

gcctgcttca tcacacagct gcttcctgtc aaacgccaat tggggttcta caattggaca     1200

tccagactca aatctcatat taacccgaca gggactgttc tcctccagct ggaaaacaca     1260

atgcagatga gcctgaagga tctcttgtga                                      1290


<210>  70
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atgggctggc caggacacct      120

actatgggct ggctccactg ggagcgcttt atgtgtaacc tcgactgcca agaggagcca      180

gactcatgca tctctgagaa gttgttcgag gagatggcag aacgaatggt gacagatgga      240

tggaaggacg ctggctacga gtatctgtgc atagatgatt gttggatggc ccctcagcga      300

gactcagagg ggagactcca ggccgacccc cagcgatttc cacacggaat ccggcaactg      360

gctaaccatg tgcactcaaa agggctcaag ctgggaattt atgctgacgt cgggaacaaa      420

acttgtgcgg ggtttcccgg ctccttcgga tattacgaca tcgacgccca gactttcgca      480

gactggggtg tggacctgct taagttcgac ggctgttact gcgatagtct ggaaaacttg      540

gctgacggct ataagcacat gagtctcgcc ctgaaccgaa caggcagaag catagtctac      600

tcctgcgaat ggccacttta catgtggcca ttccagaaac ctaattatac cgagatcaga      660

caatactgta accattggcg aaacttcgcc gacattgacg atagttggaa gtcaatcaag      720

tccatcctgg attggacctc taggaaccag gaaaggatcg tggacgtggc tggacctggc      780

ggatggaacg atccagacat gctcgtgata ggaaactttg gactgtcatg gaatcagcaa      840

gtaacacaga tggcgctctg ggccattatg gctgccccct tgtttatgtc taacgacctg      900

aggcatatct ctcctcaagc caaggcactc ctgcaggaca aggacgttat cgccatcaac      960

caggacccac tgggcaagca gggataccag ctgcggaaag gtgataactt cgaggtctgg     1020

gagcgaccgc tttcaggaga cgcctgggca gttgcaatca tcaacaggca agaaattggt     1080

gggccacggt cttatactat tcccgtggct tctctcggta agggcgtcgc ctgcaacccc     1140

gcctgcttta tcacccaatt gttgcccgtt aagagaaaac tgggatttta cgagtggaca     1200

tccaggctgc ggtctcatat taacccgaca gggactgttc tcctccagct ggaaaacaca     1260

atgcagatga gcctgaagga tctcttgtga                                      1290


<210>  71
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atgggctggc caggacacct      120

actatgggct ggctccactg ggagcgcttt atgtgtaacc tcgactgcca agaggagcca      180

gactcatgca tctctgagaa gttgttcgaa gagatggctg aactgatggt gtccgagggg      240

tggaaggatg cagggtacga gtacctttgc atagacgatt gctggatggc accacagcgg      300

gatagtgagg gcaggttgca ggcggacccc caaagatttc cacatggcat cagacagctg      360

gccaaccacg tgcactctaa aggcctgaag ctggggattt acgccgatgt cggtaataaa      420

acatgtgctg gtttccccgg tagctttgga tactacgaca tcgacgccca gacatttgct      480

gattggggag tggacctgct caagttcgac ggctgctact gcgattctct ggaaaatctg      540

gccgatgggt ataagcacat gagtcttgct cttaatagaa ccggacgctc tatagtctat      600

tcatgtgagt ggccactgta catgtggcca tttcagaaac ccaactatac cgaaattaga      660

cagtattgta accactggcg gaatttcgcc gacatagacg atagctggaa gagcatcaag      720

tcaattctcg attggacttc attcaaccag gagcggatcg tcgacgtggc cggccctggg      780

ggctggaatg atccagatat gctggtgatc ggaaactttg gtctctcctg gaatcaacag      840

gtcactcaga tggccctctg ggccattatg gcagcaccac tctttatgag caacgacctg      900

agacacattt ccccacaggc caaggcattg ctgcaggaca aagacgtgat cgccattaac      960

caggacccac tgggcaagca agggtaccaa cttaggcagg gagataattt tgaggtctgg     1020

gagcgcccac tcagcggaga cgcctgggcc gttgccatga taaacagaca ggagattggc     1080

ggccccagat cctacacaat tcctgtcgct agcctgggca agggggtggc ttgtaatccc     1140

gcctgcttta taacccagct gctgccagtg aaacggaaac tcgggttcta tgaatggact     1200

tctaggctca ggtctcatat taacccgaca gggactgttc tcctccagct ggaaaacaca     1260

atgcagatga gcctgaagga tctcttgtga                                      1290


<210>  72
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcattggaca atgggctggc caggacacct      120

actatgggct ggctccactg ggagcgcttt atgtgtaacc tcgactgcca agaggagcca      180

gactcatgca tctctgagaa gttgttcgag gagatggcag aacgaatggt gacagatgga      240

tggaaggacg ctggctacga gtatctgtgc atagatgatt gttggatggc ccctcagcga      300

gactcagagg ggagactcca ggccgacccc cagcgatttc cacacggaat ccggcaactg      360

gctaaccatg tgcactcaaa agggctcaag ctgggaattt atgctgacgt cgggaacaaa      420

acttgtgcgg ggtttcccgg ctccttcgga tattacgaca tcgacgccca gactttcgca      480

gactggggtg tggacctgct taagttcgac ggctgttact gcgatagtct ggaaaacttg      540

gctgacggct ataagcacat gagtctcgcc ctgaaccgaa caggcagaag catagtctac      600

tcctgcgaat ggccacttta catgtggcca ttccagaaac ctaattatac cgagatcaga      660

caatactgta accattggcg aaacttcgcc gacattgacg atagttggaa gtcaatcaag      720

tccatcctgg attggacctc taggaaccag gaaaggatcg tggacgtggc tggacctggc      780

ggatggaacg atccagacat gctcgtgata ggaaactttg gactgtcatg ggatcagcaa      840

gtaacacaga tggcgctctg ggccattatg gctgccccct tgtttatgtc taacgacctg      900

aggcatatct ctcctcaagc caaggcactc ctgcaggaca aggacgttat cgccatcaac      960

caggacccac tgggcaagca gggataccag ctgcggaaag gtgataactt cgaggtctgg     1020

gagcgaccgc tttcaggaga cgcctgggca gttgcaatca tcaacaggca agaaattggt     1080

gggccacggt cttatactat tcccgtggct tctctcggta agggcgtcgc ctgcaacccc     1140

gcctgcttta tcacccaatt gttgcccgtt aagagaaaac tgggatttta cgaggcgaca     1200

tccaggctga agtctcatat taacccgaca gggactgttc tcctccagct ggaaaacaca     1260

atgcagatga gcctgaagga tctcttgtga                                      1290


<210>  73
<211>  1289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcatggacaa tggattggca aggacgccta      120

ccatgggctg gctgcactgg gagcgcttca tgtgcaacct tgactgccag gaagagccag      180

attcctgcat cagtgagaag ctcttcgagg agatggcaga gagaatggtc accgacggct      240

ggaaggatgc aggttatgag tacctctgca ttgatgactg ttggatggct ccccaaagag      300

attcagaagg cagacttcag gcagaccctc agcgctttcc tcatgggatt cgccagctag      360

ctaatcacgt tcacagcaaa ggactgaagc tagggattta tgcagatgtt ggaaataaaa      420

cctgcgcagg cttccctggg agttttggat actacgacat tgatgcccag acctttgctg      480

actggggagt agatctgcta aaatttgatg gttgttactg tgacagtttg gaaaatttgg      540

cagatggtta taagcacatg tccttggccc tgaataggac tggcagaagc attgtgtact      600

cctgtgagtg gcctctttat atgtggccct ttcaaaagcc caattataca gaaatccgac      660

agtactgcaa tcactggcga aattttgctg acattgatga ttcctgggcc agtataaaga      720

gtatcttgga ctggacatct agaaaccagg agagaattgt tgatgttgct ggaccagggg      780

gttggaatga cccagatatg ttagtgattg gcaactttgg cctcagctgg gaccagcaag      840

taactcagat ggccctctgg gctatcatgg ctgctccttt attcatgtct aatgacctcc      900

gacacatcag ccctcaagcc aaagctctcc ttcaggataa ggacgtaatt gccatcaatc      960

aggacccctt gggcaagcaa gggtaccagc ttagaaaggg agacaacttt gaagtgtggg     1020

aacgacctct ctcaggcgat gcctgggctg tagctatcat aaaccggcag gagattggtg     1080

gacctcgctc ttataccatc cccgttgctt ccctgggtaa aggagtggcc tgtaatcctg     1140

cctgcttcat cacacagctc ctccctgtga aaaggcagct agggttctat aactggactt     1200

caaggttaaa gagtcacata aatcccacag gcactgtttt gcttcagcta gaaaatacaa     1260

tgcagatgtc attaaaagac ttactttaa                                       1289


<210>  74
<211>  1289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gcatggacaa tggattggca aggacgcctc      120

ccatgggctg gctgcactgg gagcgcttca tgtgcaacct tgactgccag gaagagccag      180

attcctgcat cagtgagaag ctcttcgagg agatggcaga gagaatggtc accgacggct      240

ggaaggatgc aggttatgag tacctctgca ttgatgactg ttggatggct ccccaaagag      300

attcagaagg cagacttcag gcagaccctc agcgctttcc tcatgggatt cgccagctag      360

ctaatcacgt tcacagcaaa ggactgaagc tagggattta tgcagatgtt ggaaataaaa      420

cctgcgcagg cttccctggg agttttggat actacgacat tgatgcccag acctttgctg      480

actggggagt agatctgcta aaatttgatg gttgttactg tgacagtttg gaaaatttgg      540

cagatggtta taagcacatg tccttggccc tgaataagac tggcagaccc attgtgtact      600

cctgtgagtg gcctctttat atgtggccct ttcaaaagcc caattataca gaaatccgac      660

agtactgcaa tcactggcga aattttgctg acattgatga ttcctgggcc agtataaaga      720

gtatcttgga ctggacatct agaaaccagg agagaattgt tgatgttgct ggaccagggg      780

gttggaatga cccagatatg ttagtgattg gcaactttgg cctcagctgg gaccagcaag      840

taactcagat ggccctctgg gctatcatgg ctgctccttt attcatgtct aatgacctcc      900

gacacatcag ccctcaagcc aaagctctcc ttcaggataa ggacgtaatt gccatcaatc      960

aggacccctt gggcaagcaa gggtaccagc ttagaaaggg agacaacttt gaagtgtggg     1020

aacgacctct ctcaggcgat gcctgggctg tagctatcat aaaccggcag gagattggtg     1080

gacctcgctc ttataccatc cccgttgctt ccctgggtaa aggagtggcc tgtaatcctg     1140

cctgcttcat cacacagctc ctccctgtga aaaggcagct agggttctat aactggactt     1200

caaggttaaa gagtcacata aatcccacag gcactgtttt gcttcagcta gaaaatacaa     1260

tgcagatgtc attaaaagac ttactttaa                                       1289


<210>  75
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  76
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala 
            20                  25                  30      


<210>  77
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
atgcagctga ggaacccaga actacatctg ggctgcgcgc ttgcgcttcg cttcctggcc       60

ctcgtttcct gggacatccc tggggctaga gca                                    93


