                         SEQUENCE LISTING

<110>  LOGICBIO THERAPEUTICS, INC.
 
<120>  MANUFACTURING AND USE OF RECOMBINANT AAV VECTORS

<130>  2012538-0213

<140>  PCT/US2022/017901
<141>  2022-02-25

<150>  US 63/154,474
<151>  2021-02-26

<150>  US 63/234,610
<151>  2021-08-18

<150>  US 63/257,036
<151>  2021-10-18

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  20985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Rep/Helper Plasmid

<400>  1
tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta       60

tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag      120

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg      180

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg      240

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg      300

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga      360

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc      420

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt      480

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact      540

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg      600

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt      660

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt      720

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct      780

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg      840

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt      900

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttattagaa aaactcatcg      960

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa     1020

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc     1080

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg     1140

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat     1200

ggcaaaagtt tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca     1260

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga     1320

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg     1380

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg     1440

aatgctgttt ttccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata     1500

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca     1560

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg     1620

ggcttcccat acaagcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat     1680

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga cgtttcccgt     1740

tgaatatggc tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     1800

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     1860

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     1920

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     1980

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     2040

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac     2100

tatgcggcat cagagcagat tgtactgaga gtgcaccata aaattgtaaa cgttacgtca     2160

tagggttagg gaggtcctgt attagaggtc acgtgagtgt tttgcgacat tttgcgacac     2220

catgtggtca cgctgggtat ttaagcccga gtgagcacgc agggtctcca ttttgaagcg     2280

ggaggtttga acgcgcagcc gccatgccgg ggttttacga gattgtgatt aaggtcccca     2340

gcgaccttga cgagcatctg cccggcattt ctgacagctt tgtgaactgg gtggccgaga     2400

aggaatggga gttgccgcca gattctgaca tggatctgaa tctgattgag caggcacccc     2460

tgaccgtggc cgagaagctg cagcgcgact ttctgacgga atggcgccgt gtgagtaagg     2520

ccccggaggc ccttttcttt gtgcaatttg agaagggaga gagctacttc cacatgcacg     2580

tgctcgtgga aaccaccggg gtgaaatcca tggttttggg acgtttcctg agtcagattc     2640

gcgaaaaact gattcagaga atttaccgcg ggatcgagcc gactttgcca aactggttcg     2700

cggtcacaaa gaccagaaat ggcgccggag gcgggaacaa ggtggtggat gagtgctaca     2760

tccccaatta cttgctcccc aaaacccagc ctgagctcca gtgggcgtgg actaatatgg     2820

aacagtattt aagcgcctgt ttgaatctca cggagcgtaa acggttggtg gcgcagcatc     2880

tgacgcacgt gtcgcagacg caggagcaga acaaagagaa tcagaatccc aattctgatg     2940

cgccggtgat cagatcaaaa acttcagcca ggtacatgga gctggtcggg tggctcgtgg     3000

acaaggggat tacctcggag aagcagtgga tccaggagga ccaggcctca tacatctcct     3060

tcaatgcggc ctccaactcg cggtcccaaa tcaaggctgc cttggacaat gcgggaaaga     3120

ttatgagcct gactaaaacc gcccccgact acctggtggg ccagcagccc gtggaggaca     3180

tttccagcaa tcggatttat aaaattttgg aactaaacgg gtacgatccc caatatgcgg     3240

cttccgtctt tctgggatgg gccacgaaaa agttcggcaa gaggaacacc atctggctgt     3300

ttgggcctgc aactaccggg aagaccaaca tcgcggaggc catagcccac actgtgccct     3360

tctacgggtg cgtaaactgg accaatgaga actttccctt caacgactgt gtcgacaaga     3420

tggtgatctg gtgggaggag gggaagatga ccgccaaggt cgtggagtcg gccaaagcca     3480

ttctcggagg aagcaaggtg cgcgtggacc agaaatgcaa gtcctcggcc cagatagacc     3540

cgactcccgt gatcgtcacc tccaacacca acatgtgcgc cgtgattgac gggaactcaa     3600

cgaccttcga acaccagcag ccgttgcaag accggatgtt caaatttgaa ctcacccgcc     3660

gtctggatca tgactttggg aaggtcacca agcaggaagt caaagacttt ttccggtggg     3720

caaaggatca cgtggttgag gtggagcatg aattctacgt caaaaagggt ggagccaaga     3780

aaagacccgc ccccagtgac gcagatataa gtgagcccaa acgggtgcgc gagtcagttg     3840

cgcagccatc gacgtcagac gcggaagctt cgatcaacta cgcagacagg taccaaaaca     3900

aatgttctcg tcacgtgggc atgaatctga tgctgtttcc ctgcagacaa tgcgagagaa     3960

tgaatcagaa ttcaaatatc tgcttcactc acggacagaa agactgttta gagtgctttc     4020

ccgtgtcaga atctcaaccc gtttctgtcg tcaaaaaggc gtatcagaaa ctgtgctaca     4080

ttcatcatat catgggaaag gtgccagacg cttgcactgc ctgcgatctg gtcaatgtgg     4140

atttggatga ctgcatcttt gaacaataaa tgatttaaat caggtatggc tgccgatggt     4200

tatcttccag attggctcga ggacactctc tctgatcgac gtttaaacca tatgaacgtt     4260

aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt taaccaatag     4320

gccgaaatcg gcaaaatccc ttataaatca aaagaatagc ccgagatagg gttgagtgtt     4380

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga     4440

aaaaccgtct atcagggcga tggcccacta cgtgaaccat cacccaaatc aagttttttg     4500

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct     4560

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc     4620

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt     4680

aatgcgccgc tacagggcgc gtactatggt tgctttgacg tatgcggtgt gaaataccgc     4740

acagatgcgt aaggagaaaa taccgcatca ggcgccattc gccattcagg ctgcgcaact     4800

gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat     4860

gtgctgcaag gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa     4920

cgacggccag tgccaagctt aaggtgcacg gcccacgtgg ccactagtac ttctcgacag     4980

aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca tgccccaggc     5040

ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt ctaccggcac     5100

ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga     5160

gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg     5220

ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct gcacctgcgt     5280

gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt     5340

gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct gcgagagctc     5400

ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc aagtccgcac     5460

caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag     5520

ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc cgtagatgta     5580

cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg     5640

gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct ggccggtcag     5700

gcgcgcgcaa tcgttgacgc tctaccgtgc aaaaggagag cctgtaagcg ggcactcttc     5760

cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt tcgagccccg     5820

tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg     5880

acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg gctgctgcgc     5940

tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat     6000

taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc gcgggacccc     6060

cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca     6120

agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc ttttcccaga     6180

tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag caagagcagc     6240

ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg     6300

ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg cactacctgg     6360

acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag cggtacccaa     6420

gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg     6480

accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca gggcgcgagc     6540

tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag cccgacgcgc     6600

gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta accgcatacg     6660

agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac gtgcgtacgc     6720

ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt gtaagcgcgc     6780

tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata gtgcagcaca     6840

gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc gagggccgct     6900

ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc agcttgagcc     6960

tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag ttttacgccc     7020

gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc gaggggttct     7080

acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg     7140

agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga     7200

tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag gccgagtcct     7260

actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg gaggcagctg     7320

gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg     7380

aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg gtgatgtttc     7440

tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc agagccagcc     7500

gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca tgtcgctgac     7560

tgcgcgcaat cctgacgcgt tccggcagca gccgcaggcc aaccggctct ccgcaattct     7620

ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa     7680

cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct acgacgcgct     7740

gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg accggctggt     7800

gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg     7860

ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc cgcggggaca     7920

ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga caccgcaaag     7980

tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag gcctgcagac     8040

cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc gggctcccac     8100

aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct     8160

aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag gtcacttgct     8220

gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt tccaggagat     8280

tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg caaccctaaa     8340

ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttcg caccctttgg     8400

cgcatcccat tctccagtaa ctttatgtcc atgggcgcac tcacagacct gggccaaaac     8460

cttctctacg ccaactccgc ccacgcgcta gacatgactt ttgaggtgga tcccatggac     8520

gagcccaccc ttctttatgt tttgtttgaa gtctttgacg tggtccgtgt gcaccggccg     8580

caccgcggcg tcatcgaaac cgtgtacctg cgcacgccct tctcggccgg caacgccaca     8640

acataaagaa gcaagcaaca tcaacaacag ctgccgccat gggctccagt gagcaggaac     8700

tgaaagccat tgtcaaagat cttggttgtg ggccatattt tttgggcacc tatgacaagc     8760

gctttccagg ctttgtttct ccacacaagc tcgcctgcgc catagtcaat acggccggtc     8820

gcgagactgg gggcgtacac tggatggcct ttgcctggaa cccgcactca aaaacatgct     8880

acctctttga gccctttggc ttttctgacc agcgactcaa gcaggtttac cagtttgagt     8940

acgagtcact cctgcgccgt agcgccattg cttcttcccc cgaccgctgt ataacgctgg     9000

aaaagtccac ccaaagcgta caggggccca actcggccgc ctgtggacta ttctgctgca     9060

tgtttctcca cgcctttgcc aactggcccc aaactcccat ggatcacaac cccaccatga     9120

accttattac cggggtaccc aactccatgc tcaacagtcc ccaggtacag cccaccctgc     9180

gtcgcaacca ggaacagctc tacagcttcc tggagcgcca ctcgccctac ttccgcagcc     9240

acagtgcgca gattaggagc gccacttctt tttgtcactt gaaaaacatg taaaaataat     9300

gtactagaga cactttcaat aaaggcaaat gcttttattt gtacactctc gggtgattat     9360

ttacccccac ccttgccgtc tgcgccgttt aaaaatcaaa ggggttctgc cgcgcatcgc     9420

tatgcgccac tggcagggac acgttgcgat actggtgttt agtgctccac ttaaactcag     9480

gcacaaccat ccgcggcagc tcggtgaagt tttcactcca caggctgcgc accatcacca     9540

acgcgtttag caggtcgggc gccgatatct tgaagtcgca gttggggcct ccgccctgcg     9600

cgcgcgagtt gcgatacaca gggttgcagc actggaacac tatcagcgcc gggtggtgca     9660

cgctggccag cacgctcttg tcggagatca gatccgcgtc caggtcctcc gcgttgctca     9720

gggcgaacgg agtcaacttt ggtagctgcc ttcccaaaaa gggcgcgtgc ccaggctttg     9780

agttgcactc gcaccgtagt ggcatcaaaa ggtgaccgtg cccggtctgg gcgttaggat     9840

acagcgcctg cataaaagcc ttgatctgct taaaagccac ctgagccttt gcgccttcag     9900

agaagaacat gccgcaagac ttgccggaaa actgattggc cggacaggcc gcgtcgtgca     9960

cgcagcacct tgcgtcggtg ttggagatct gcaccacatt tcggccccac cggttcttca    10020

cgatcttggc cttgctagac tgctccttca gcgcgcgctg cccgttttcg ctcgtcacat    10080

ccatttcaat cacgtgctcc ttatttatca taatgcttcc gtgtagacac ttaagctcgc    10140

cttcgatctc agcgcagcgg tgcagccaca acgcgcagcc cgtgggctcg tgatgcttgt    10200

aggtcacctc tgcaaacgac tgcaggtacg cctgcaggaa tcgccccatc atcgtcacaa    10260

aggtcttgtt gctggtgaag gtcagctgca acccgcggtg ctcctcgttc agccaggtct    10320

tgcatacggc cgccagagct tccacttggt caggcagtag tttgaagttc gcctttagat    10380

cgttatccac gtggtacttg tccatcagcg cgcgcgcagc ctccatgccc ttctcccacg    10440

cagacacgat cggcacactc agcgggttca tcaccgtaat ttcactttcc gcttcgctgg    10500

gctcttcctc ttcctcttgc gtccgcatac cacgcgccac tgggtcgtct tcattcagcc    10560

gccgcactgt gcgcttacct cctttgccat gcttgattag caccggtggg ttgctgaaac    10620

ccaccatttg tagcgccaca tcttctcttt cttcctcgct gtccacgatt acctctggtg    10680

atggcgggcg ctcgggcttg ggagaagggc gcttcttttt cttcttgggc gcaatggcca    10740

aatccgccgc cgaggtcgat ggccgcgggc tgggtgtgcg cggcaccagc gcgtcttgtg    10800

atgagtcttc ctcgtcctcg gactcgatac gccgcctcat ccgctttttt gggggcgccc    10860

ggggaggcgg cggcgacggg gacggggacg acacgtcctc catggttggg ggacgtcgcg    10920

ccgcaccgcg tccgcgctcg ggggtggttt cgcgctgctc ctcttcccga ctggccattt    10980

ccttctccta taggcagaaa aagatcatgg agtcagtcga gaagaaggac agcctaaccg    11040

ccccctctga gttcgccacc accgcctcca ccgatgccgc caacgcgcct accaccttcc    11100

ccgtcgaggc acccccgctt gaggaggagg aagtgattat cgagcaggac ccaggttttg    11160

taagcgaaga cgacgaggac cgctcagtac caacagagga taaaaagcaa gaccaggaca    11220

acgcagaggc aaacgaggaa caagtcgggc ggggggacga aaggcatggc gactacctag    11280

atgtgggaga cgacgtgctg ttgaagcatc tgcagcgcca gtgcgccatt atctgcgacg    11340

cgttgcaaga gcgcagcgat gtgcccctcg ccatagcgga tgtcagcctt gcctacgaac    11400

gccacctatt ctcaccgcgc gtacccccca aacgccaaga aaacggcaca tgcgagccca    11460

acccgcgcct caacttctac cccgtatttg ccgtgccaga ggtgcttgcc acctatcaca    11520

tctttttcca aaactgcaag atacccctat cctgccgtgc caaccgcagc cgagcggaca    11580

agcagctggc cttgcggcag ggcgctgtca tacctgatat cgcctcgctc aacgaagtgc    11640

caaaaatctt tgagggtctt ggacgcgacg agaagcgcgc ggcaaacgct ctgcaacagg    11700

aaaacagcga aaatgaaagt cactctggag tgttggtgga actcgagggt gacaacgcgc    11760

gcctagccgt actaaaacgc agcatcgagg tcacccactt tgcctacccg gcacttaacc    11820

taccccccaa ggtcatgagc acagtcatga gtgagctgat cgtgcgccgt gcgcagcccc    11880

tggagaggga tgcaaatttg caagaacaaa cagaggaggg cctacccgca gttggcgacg    11940

agcagctagc gcgctggctt caaacgcgcg agcctgccga cttggaggag cgacgcaaac    12000

taatgatggc cgcagtgctc gttaccgtgg agcttgagtg catgcagcgg ttctttgctg    12060

acccggagat gcagcgcaag ctagaggaaa cattgcacta cacctttcga cagggctacg    12120

tacgccaggc ctgcaagatc tccaacgtgg agctctgcaa cctggtctcc taccttggaa    12180

ttttgcacga aaaccgcctt gggcaaaacg tgcttcattc cacgctcaag ggcgaggcgc    12240

gccgcgacta cgtccgcgac tgcgtttact tatttctatg ctacacctgg cagacggcca    12300

tgggcgtttg gcagcagtgc ttggaggagt gcaacctcaa ggagctgcag aaactgctaa    12360

agcaaaactt gaaggaccta tggacggcct tcaacgagcg ctccgtggcc gcgcacctgg    12420

cggacatcat tttccccgaa cgcctgctta aaaccctgca acagggtctg ccagacttca    12480

ccagtcaaag catgttgcag aactttagga actttatcct agagcgctca ggaatcttgc    12540

ccgccacctg ctgtgcactt cctagcgact ttgtgcccat taagtaccgc gaatgccctc    12600

cgccgctttg gggccactgc taccttctgc agctagccaa ctaccttgcc taccactctg    12660

acataatgga agacgtgagc ggtgacggtc tactggagtg tcactgtcgc tgcaacctat    12720

gcaccccgca ccgctccctg gtttgcaatt cgcagctgct taacgaaagt caaattatcg    12780

gtacctttga gctgcagggt ccctcgcctg acgaaaagtc cgcggctccg gggttgaaac    12840

tcactccggg gctgtggacg tcggcttacc ttcgcaaatt tgtacctgag gactaccacg    12900

cccacgagat taggttctac gaagaccaat cccgcccgcc atatgcggag cttaccgcct    12960

gcgtcattac ccagggccac attcttggcc aattgcaagc catcaacaaa gcccgccaag    13020

agtttctgct acgaaaggga cggggggttt acttggaccc ccagtccggc gaggagctca    13080

acccaatccc cccgccgccg cagccctatc agcagcagcc gcgggccctt gcttcccagg    13140

atggcaccca aaaagaagct gcagctgccg ccgccaccca cggacgagga ggaatactgg    13200

gacagtcagg cagaggaggt tttggacgag gaggaggagg acatgatgga agactgggag    13260

agcctagacg aggaagcttc cgaggtcgaa gaggtgtcag acgaaacacc gtcaccctcg    13320

gtcgcattcc cctcgccggc gccccagaaa tcggcaaccg gttccagcat ggctacaacc    13380

tccgctcctc aggcgccgcc ggcactgccc gttcgccgac ccaaccgtag atgggacacc    13440

actggaacca gggccggtaa gtccaagcag ccgccgccgt tagcccaaga gcaacaacag    13500

cgccaaggct accgctcatg gcgcgggcac aagaacgcca tagttgcttg cttgcaagac    13560

tgtgggggca acatctcctt cgcccgccgc tttcttctct accatcacgg cgtggccttc    13620

ccccgtaaca tcctgcatta ctaccgtcat ctctacagcc catactgcac cggcggcagc    13680

ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga ctctgacaaa    13740

gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc tggcgcccaa    13800

cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt atgctatatt    13860

tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc tgcgatccct    13920

cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc tggaagacgc    13980

ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc gcgccctttc    14040

tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc cagcacctgt    14100

tgtcagcgcc attatgagca aggaaattcc cacgccctac atgtggagtt accagccaca    14160

aatgggactt gcggctggag ctgcccaaga ctactcaacc cgaataaact acatgagcgc    14220

gggaccccac atgatatccc gggtcaacgg aatacgcgcc caccgaaacc gaattctctc    14280

ggaacaggcg gctattacca ccacacctcg taataacctt aatccccgta gttggcccgc    14340

tgccctggtg taccaggaaa gtcccgctcc caccactgtg gtacttccca gagacgccca    14400

ggccgaagtt cagatgacta actcaggggc gcagcttgcg ggcggctttc gtcacagggt    14460

gcggtcgccc gggcagggta taactcacct gacaatcaga gggcgaggta ttcagctcaa    14520

cgacgagtcg gtgagctcct cgcttggtct ccgtccggac gggacatttc agatcggcgg    14580

cgccggccgc tcttcattca cgcctcgtca ggcaatccta actctgcaga cctcgtcctc    14640

tgagccgcgc tctggaggca ttggaactct gcaatttatt gaggagtttg tgccatcggt    14700

ctactttaac cccttctcgg gacctcccgg ccactatccg gatcaattta ttcctaactt    14760

tgacgcggta aaggactcgg cggacggcta cgactgaatg ttaagtggag aggcagagca    14820

actgcgcctg aaacacctgg tccactgtcg ccgccacaag tgctttgccc gcgactccgg    14880

tgagttttgc tactttgaat tgcccgagga tcatatcgag ggcccggcgc acggcgtccg    14940

gcttaccgcc cagggagagc ttgcccgtag cctgattcgg gagtttaccc agcgccccct    15000

gctagttgag cgggacaggg gaccctgtgt tctcactgtg atttgcaact gtcctaaccc    15060

tggattacat caagatcctc tagttaatta actagagtac ccggggatct tattcccttt    15120

aactaataaa aaaaaataat aaagcatcac ttacttaaaa tcagttagca aatttctgtc    15180

cagtttattc agcagcacct ccttgccctc ctcccagctc tggtattgca gcttcctcct    15240

ggctgcaaac tttctccaca atctaaatgg aatgtcagtt tcctcctgtt cctgtccatc    15300

cgcacccact atcttcatgt tgttgcagat gaagcgcgca agaccgtctg aagatacctt    15360

caaccccgtg tatccatatg acacggaaac cggtcctcca actgtgcctt ttcttactcc    15420

tccctttgta tcccccaatg ggtttcaaga gagtccccct ggggtactct ctttgcgcct    15480

atccgaacct ctagttacct ccaatggcat gcttgcgctc aaaatgggca acggcctctc    15540

tctggacgag gccggcaacc ttacctccca aaatgtaacc actgtgagcc cacctctcaa    15600

aaaaaccaag tcaaacataa acctggaaat atctgcaccc ctcacagtta cctcagaagc    15660

cctaactgtg gctgccgccg cacctctaat ggtcgcgggc aacacactca ccatgcaatc    15720

acaggccccg ctaaccgtgc acgactccaa acttagcatt gccacccaag gacccctcac    15780

agtgtcagaa ggaaagctag ccctgcaaac atcaggcccc ctcaccacca ccgatagcag    15840

tacccttact atcactgcct caccccctct aactactgcc actggtagct tgggcattga    15900

cttgaaagag cccatttata cacaaaatgg aaaactagga ctaaagtacg gggctccttt    15960

gcatgtaaca gacgacctaa acactttgac cgtagcaact ggtccaggtg tgactattaa    16020

taatacttcc ttgcaaacta aagttactgg agccttgggt tttgattcac aaggcaatat    16080

gcaacttaat gtagcaggag gactaaggat tgattctcaa aacagacgcc ttatacttga    16140

tgttagttat ccgtttgatg ctcaaaacca actaaatcta agactaggac agggccctct    16200

ttttataaac tcagcccaca acttggatat taactacaac aaaggccttt acttgtttac    16260

agcttcaaac aattccaaaa agcttgaggt taacctaagc actgccaagg ggttgatgtt    16320

tgacgctaca gccatagcca ttaatgcagg agatgggctt gaatttggtt cacctaatgc    16380

accaaacaca aatcccctca aaacaaaaat tggccatggc ctagaatttg attcaaacaa    16440

ggctatggtt cctaaactag gaactggcct tagttttgac agcacaggtg ccattacagt    16500

aggaaacaaa aataatgata agctaacttt gtggaccaca ccagctccat ctcctaactg    16560

tagactaaat gcagagaaag atgctaaact cactttggtc ttaacaaaat gtggcagtca    16620

aatacttgct acagtttcag ttttggctgt taaaggcagt ttggctccaa tatctggaac    16680

agttcaaagt gctcatctta ttataagatt tgacgaaaat ggagtgctac taaacaattc    16740

cttcctggac ccagaatatt ggaactttag aaatggagat cttactgaag gcacagccta    16800

tacaaacgct gttggattta tgcctaacct atcagcttat ccaaaatctc acggtaaaac    16860

tgccaaaagt aacattgtca gtcaagttta cttaaacgga gacaaaacta aacctgtaac    16920

actaaccatt acactaaacg gtacacagga aacaggagac acaactccaa gtgcatactc    16980

tatgtcattt tcatgggact ggtctggcca caactacatt aatgaaatat ttgccacatc    17040

ctcttacact ttttcataca ttgcccaaga ataaagaatc gtttgtgtta tgtttcaacg    17100

tgtttatttt tcaattgcag aaaatttcaa gtcatttttc attcagtagt atagccccac    17160

caccacatag cttatacaga tcaccgtacc ttaatcaaac tcacagaacc ctagtattca    17220

acctgccacc tccctcccaa cacacagagt acacagtcct ttctccccgg ctggccttaa    17280

aaagcatcat atcatgggta acagacatat tcttaggtgt tatattccac acggtttcct    17340

gtcgagccaa acgctcatca gtgatattaa taaactcccc gggcagctca cttaagttca    17400

tgtcgctgtc cagctgctga gccacaggct gctgtccaac ttgcggttgc ttaacgggcg    17460

gcgaaggaga agtccacgcc tacatggggg tagagtcata atcgtgcatc aggatagggc    17520

ggtggtgctg cagcagcgcg cgaataaact gctgccgccg ccgctccgtc ctgcaggaat    17580

acaacatggc agtggtctcc tcagcgatga ttcgcaccgc ccgcagcata aggcgccttg    17640

tcctccgggc acagcagcgc accctgatct cacttaaatc agcacagtaa ctgcagcaca    17700

gcaccacaat attgttcaaa atcccacagt gcaaggcgct gtatccaaag ctcatggcgg    17760

ggaccacaga acccacgtgg ccatcatacc acaagcgcag gtagattaag tggcgacccc    17820

tcataaacac gctggacata aacattacct cttttggcat gttgtaattc accacctccc    17880

ggtaccatat aaacctctga ttaaacatgg cgccatccac caccatccta aaccagctgg    17940

ccaaaacctg cccgccggct atacactgca gggaaccggg actggaacaa tgacagtgga    18000

gagcccagga ctcgtaacca tggatcatca tgctcgtcat gatatcaatg ttggcacaac    18060

acaggcacac gtgcatacac ttcctcagga ttacaagctc ctcccgcgtt agaaccatat    18120

cccagggaac aacccattcc tgaatcagcg taaatcccac actgcaggga agacctcgca    18180

cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg cagcagcgga tgatcctcca    18240

gtatggtagc gcgggtttct gtctcaaaag gaggtagacg atccctactg tacggagtgc    18300

gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc aaatggaacg ccggacgtag    18360

tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa cagatctgcg tctccggtct    18420

cgccgcttag atcgctctgt gtagtagttg tagtatatcc actctctcaa agcatccagg    18480

cgccccctgg cttcgggttc tatgtaaact ccttcatgcg ccgctgccct gataacatcc    18540

accaccgcag aataagccac acccagccaa cctacacatt cgttctgcga gtcacacacg    18600

ggaggagcgg gaagagctgg aagaaccatg tttttttttt tattccaaaa gattatccaa    18660

aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct ccggtggcgt ggtcaaactc    18720

tacagccaaa gaacagataa tggcatttgt aagatgttgc acaatggctt ccaaaaggca    18780

aacggccctc acgtccaagt ggacgtaaag gctaaaccct tcagggtgaa tctcctctat    18840

aaacattcca gcaccttcaa ccatgcccaa ataattctca tctcgccacc ttctcaatat    18900

atctctaagc aaatcccgaa tattaagtcc ggccattgta aaaatctgct ccagagcgcc    18960

ctccaccttc agcctcaagc agcgaatcat gattgcaaaa attcaggttc ctcacagacc    19020

tgtataagat tcaaaagcgg aacattaaca aaaataccgc gatcccgtag gtcccttcgc    19080

agggccagct gaacataatc gtgcaggtct gcacggacca gcgcggccac ttccccgcca    19140

ggaaccatga caaaagaacc cacactgatt atgacacgca tactcggagc tatgctaacc    19200

agcgtagccc cgatgtaagc ttgttgcatg ggcggcgata taaaatgcaa ggtgctgctc    19260

aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat cgtagtcatg ctcatgcaga    19320

taaaggcagg taagctccgg aaccaccaca gaaaaagaca ccatttttct ctcaaacatg    19380

tctgcgggtt tctgcataaa cacaaaataa aataacaaaa aaacatttaa acattagaag    19440

cctgtcttac aacaggaaaa acaaccctta taagcataag acggactacg gccatgccgg    19500

cgtgaccgta aaaaaactgg tcaccgtgat taaaaagcac caccgacagc tcctcggtca    19560

tgtccggagt cataatgtaa gactcggtaa acacatcagg ttgattcaca tcggtcagtg    19620

ctaaaaagcg accgaaatag cccgggggaa tacatacccg caggcgtaga gacaacatta    19680

cagcccccat aggaggtata acaaaattaa taggagagaa aaacacataa acacctgaaa    19740

aaccctcctg cctaggcaaa atagcaccct cccgctccag aacaacatac agcgcttcca    19800

cagcggcagc cataacagtc agccttacca gtaaaaaaga aaacctatta aaaaaacacc    19860

actcgacacg gcaccagctc aatcagtcac agtgtaaaaa agggccaagt gcagagcgag    19920

tatatatagg actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac ccagaaaacc    19980

gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc acaacttcct caaatcgtca    20040

cttccgtttt cccacgttac gtaacttccc attttaagaa aactacaatt cccaacacat    20100

acaagttact ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt    20160

cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga    20220

tgatttattt tggattgaag ccaatatgat aatgaggggg tggagtttgt gacgtggcgc    20280

ggggcgtggg aacggggcgg gtgacgtagt agtgtggcgg aagtgtgatg ttgcaagtgt    20340

ggcggaacac atgtaagcga cggatgtggc aaaagtgacg tttttggtgt gcgccggatc    20400

cacaggacgg gtgtggtcgc catgatcgcg tagtcgatag tggctccaag tagcgaagcg    20460

agcaggactg ggcggcggcc aaagcggtcg gacagtgctc cgagaacggg tgcgcataga    20520

aattgcatca acgcatatag cgctagcagc acgccatagt gactggcgat gctgtcggaa    20580

tggacgatat cccgcaagag gcccggcagt accggcataa ccaagcctat gcctacagca    20640

tccagggtga cggtgccgag gatgacgatg agcgcattgt tagatttcat acacggtgcc    20700

tgactgcgtt agcaatttaa ctgtgataaa ctaccgcatt aaagcttatc gaattcgtaa    20760

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata    20820

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta    20880

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa    20940

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgc                    20985


<210>  2
<211>  22423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Rep/Helper Plasmid with intron

<400>  2
tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta       60

tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag      120

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg      180

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg      240

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg      300

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga      360

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc      420

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt      480

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact      540

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg      600

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt      660

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt      720

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct      780

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg      840

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt      900

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttattagaa aaactcatcg      960

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa     1020

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc     1080

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg     1140

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat     1200

ggcaaaagtt tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca     1260

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga     1320

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg     1380

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg     1440

aatgctgttt ttccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata     1500

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca     1560

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg     1620

ggcttcccat acaagcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat     1680

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga cgtttcccgt     1740

tgaatatggc tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     1800

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     1860

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     1920

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     1980

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     2040

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac     2100

tatgcggcat cagagcagat tgtactgaga gtgcaccata aaattgtaaa cgttcatatg     2160

gtttaaacgt cgatcagaga gagtgtcctc gagccaatct ggaagataac catcggcagc     2220

catacctgat ttaaatcatt tattgttcaa agatgcagtc atccaaatcc acattgacca     2280

gatcgcaggc agtgcaagcg tctggcacct ttcccatgat atgatgaatg tagcacagtt     2340

tctgatacgc ctttttgacg acagaaacgg gttgagattc tgacacggga aagcactcta     2400

aacagtcttt ctgtccgtga gtgaagcaga tatttgaatt ctgattcatt ctctcgcatt     2460

gtctgcaggg aaacagcatc agattcatgc ccacgtgacg agaacatttg ttttggtacc     2520

tgtctgcgta gttgatcgaa gcttccgcgt ctgacgtcga tggctgcgca actgactcgc     2580

gcacccgttt gggctcactt atatctgcgt cactgggggc gggtcttttc ttggctccac     2640

cctttttgac gtagaattca tgctccacct caaccacgtg atcctttgcc caccggaaaa     2700

agtctttgac ttcctgcttg gtgaccttcc caaagtcatg atccagacgg cgggtgagtt     2760

caaatttgaa catccggtct tgcaacggct gctggtgttc gaaggtcgtt gagttcccgt     2820

caatcacggc gcacatgttg gtgttggagg tgacgatcac gggagtcggg tctatctggg     2880

ccgaggactt gcatttctgg tccacgcgca ccttgcttcc tccgagaatg gctttggccg     2940

actccacgac cttggcggtc atcttcccct cctcccacca gatcaccatc ttgtcgacac     3000

agtcgttgaa gggaaagttc tcattggtcc agtttacgca cccgtagaag ggcacagtgt     3060

gggctatggc ctccgcgatg ttggtcttcc cggtagttgc aggcccaaac agccagatgg     3120

tgttcctctt gccgaacttt ttcgtggccc atcccagaaa gacggaagcc gcatattggg     3180

gatcgtaccc gtttagttcc aaaattttat aaatccgatt gctggaaatg tcctccacgg     3240

gctgctggcc caccaggtag tcgggggcgg ttttagtcag gctcataatc tttcccgcat     3300

tgtccaaggc agccttgatt tgggaccgcg agttggaggc cgcattgaag gagatgtatg     3360

aggcctggtc ctcctggatc cactgcttct ccgaggtaat ccccttgtcc acgagccacc     3420

cgaccagctc catgtacctg gctgaagttt ttgatctgat caccggcgca tcagaattgg     3480

gattctgatt ctctttgttc tgctcctgcg tctgcgacac gtgcgtcaga tgctgcgcca     3540

ccaaccgttt acgctccgtg agattcaaac aggcgcttaa atactgttcc atattagtcc     3600

acgcccactg gagctcaggc tgggttttgg ggagcaagta attggggatg tagcactcat     3660

ccaccacctt gttcccgcct ccggcgccat ttctggtctt tgtgaccgcg aaccagtttg     3720

gcaaagtcgg ctcgatcccg cggtaaattc tctgaatcag tttttcgcga atctgactca     3780

ggaaacgtcc caaaaccatg gatttcaccc cggtggtttc cacgagcacg tgcatgtgga     3840

agtagctctc tcccttctca aattgcacaa agaaaagggc ctccggggcc ttactcacac     3900

ggcgccattc cgtcagaaag tcgcgctgca gcttctcggc cacggtcagg ggtgcctgct     3960

caatcagatt cagatccatg tcagaatctg gcggcaactc ccattccttc tcggccaccc     4020

agttcacaaa gctgtcagaa atgccgggca gatgctcgtc aaggtcgctg gggaccttaa     4080

tcacaatctc gtaaaacccc ggcatctgaa atgtaaaaga ataattcttt agttttagca     4140

aaaaagaaaa catcatgaaa attttacatc tcttaagaaa gtctttgttt ttaatccaaa     4200

taatctgaaa gccaatttct ctttagggca tggagccaaa atctgtgatg ttcccacagt     4260

actgtataca catggagatt taggaattaa aattcaattt tacttttagt caagagaatt     4320

ccagtaataa aaggtcagat ttctaatcat atttgaattt actttggatg aaaaagaaag     4380

ttctcaaatg agcggttaac ttcacacttt gtcatcactt gaaaatagct cattgaggat     4440

ctttgcaaag tgatccatca ccctggctgg gctgttttca gaatatggtt gcccaaatga     4500

ctttgaacaa atgtctcctg aagaacagaa gcctaattat ggtccagcga cgtcgatttc     4560

acagctgaca tcatgtctgg agtgggaacc acagggccag tcagctttct gggggtgctt     4620

agggttggca cccctgatcc tggtactgtc agctactaga tttgattcta gaaagttgac     4680

aagtaagtgt gataaatgct tcctgtgaga acatgctgtt tgtccaaatg ggataatttc     4740

ttccctgtat gccttcctct gggaaataca taaagtcact gtagttgtga aaaaacaaag     4800

tgatatatgt tgcattagct aacttcctac tctttatgtc aattcttaag cttgcttttc     4860

tcccctaggg aactcaactg agtattgtgt ttccccaaat atcaactcca agatgtttga     4920

catagagaca aaatgatttt ttcctaatcc atgaaaagct ttggtgataa ctaacagctt     4980

gctaatgaaa ggttaatctt tatgttttaa ctaaaacttt aaattgaaga tatataattt     5040

aaaaaattag agacacacct cattacatac ttctgaaacc ttgaaatgtc atatatctta     5100

aaatcagact ttttgtgtaa ataaggccat tgtttgtgct tttgtttccc attttgattt     5160

caaagtggta agtccaaaca aaaataatgt ggttattttt tttcactata ttctgctatt     5220

tctttgtttt cccactttta atttttttaa accaaggaga tgaatgtttt ctaacaggaa     5280

ttacatgacc aaatcatgaa ctgaacagtg tttattaaac ataaatgcat cataagcatt     5340

gtcgatctat ttagttttaa aaatgaagaa gaagaaaacc tagctaacaa agaaccagta     5400

cttaccaacc tgcgtgctgg ctgttagact cttcaatatt gctgtcaaat catgtaatca     5460

aaatttagtg aagaagacag catcagatat ttctatatct aaaaggcaag catactcaat     5520

gtattttaaa aaaggaaaca aacggcggct gcgcgttcaa acctcccgct tcaaaatgga     5580

gaccctgcgt gctcactcgg gcttaaatac ccagcgtgac cacatggtgt cgcaaaatgt     5640

cgcaaaacac tcacgtgacc tctaatacag gacctcccta accctatgac gtaacgttaa     5700

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc     5760

cgaaatcggc aaaatccctt ataaatcaaa agaatagccc gagatagggt tgagtgttgt     5820

tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     5880

aaccgtctat cagggcgatg gcccactacg tgaaccatca cccaaatcaa gttttttggg     5940

gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg     6000

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc     6060

tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa     6120

tgcgccgcta cagggcgcgt actatggttg ctttgacgta tgcggtgtga aataccgcac     6180

agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct gcgcaactgt     6240

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     6300

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     6360

acggccagtg ccaagcttaa ggtgcacggc ccacgtggcc actagtactt ctcgacagaa     6420

gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg ccccaggctt     6480

cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct accggcactt     6540

cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg gcggcggagt     6600

ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc ctcatcggct     6660

gaagcagggc taggtcggcg acaacgcgct cggctaatat ggcctgctgc acctgcgtga     6720

gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg ttgatggtgt     6780

aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc gagagctcgg     6840

tgtacctgag acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa gtccgcacca     6900

ggtactggta tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc cagcgtaggg     6960

tggccggggc tccgggggcg agatcttcca acataaggcg atgatatccg tagatgtacc     7020

tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg cggacgcggt     7080

tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg ccggtcaggc     7140

gcgcgcaatc gttgacgctc taccgtgcaa aaggagagcc tgtaagcggg cactcttccg     7200

tggtctggtg gataaattcg caagggtatc atggcggacg accggggttc gagccccgta     7260

tccggccgtc cgccgtgatc catgcggtta ccgcccgcgt gtcgaaccca ggtgtgcgac     7320

gtcagacaac gggggagtgc tccttttggc ttccttccag gcgcggcggc tgctgcgcta     7380

gcttttttgg ccactggccg cgcgcagcgt aagcggttag gctggaaagc gaaagcatta     7440

agtggctcgc tccctgtagc cggagggtta ttttccaagg gttgagtcgc gggacccccg     7500

gttcgagtct cggaccggcc ggactgcggc gaacgggggt ttgcctcccc gtcatgcaag     7560

accccgcttg caaattcctc cggaaacagg gacgagcccc ttttttgctt ttcccagatg     7620

catccggtgc tgcggcagat gcgcccccct cctcagcagc ggcaagagca agagcagcgg     7680

cagacatgca gggcaccctc ccctcctcct accgcgtcag gaggggcgac atccgcggtt     7740

gacgcggcag cagatggtga ttacgaaccc ccgcggcgcc gggcccggca ctacctggac     7800

ttggaggagg gcgagggcct ggcgcggcta ggagcgccct ctcctgagcg gtacccaagg     7860

gtgcagctga agcgtgatac gcgtgaggcg tacgtgccgc ggcagaacct gtttcgcgac     7920

cgcgagggag aggagcccga ggagatgcgg gatcgaaagt tccacgcagg gcgcgagctg     7980

cggcatggcc tgaatcgcga gcggttgctg cgcgaggagg actttgagcc cgacgcgcga     8040

accgggatta gtcccgcgcg cgcacacgtg gcggccgccg acctggtaac cgcatacgag     8100

cagacggtga accaggagat taactttcaa aaaagcttta acaaccacgt gcgtacgctt     8160

gtggcgcgcg aggaggtggc tataggactg atgcatctgt gggactttgt aagcgcgctg     8220

gagcaaaacc caaatagcaa gccgctcatg gcgcagctgt tccttatagt gcagcacagc     8280

agggacaacg aggcattcag ggatgcgctg ctaaacatag tagagcccga gggccgctgg     8340

ctgctcgatt tgataaacat cctgcagagc atagtggtgc aggagcgcag cttgagcctg     8400

gctgacaagg tggccgccat caactattcc atgcttagcc tgggcaagtt ttacgcccgc     8460

aagatatacc atacccctta cgttcccata gacaaggagg taaagatcga ggggttctac     8520

atgcgcatgg cgctgaaggt gcttaccttg agcgacgacc tgggcgttta tcgcaacgag     8580

cgcatccaca aggccgtgag cgtgagccgg cggcgcgagc tcagcgaccg cgagctgatg     8640

cacagcctgc aaagggccct ggctggcacg ggcagcggcg atagagaggc cgagtcctac     8700

tttgacgcgg gcgctgacct gcgctgggcc ccaagccgac gcgccctgga ggcagctggg     8760

gccggacctg ggctggcggt ggcacccgcg cgcgctggca acgtcggcgg cgtggaggaa     8820

tatgacgagg acgatgagta cgagccagag gacggcgagt actaagcggt gatgtttctg     8880

atcagatgat gcaagacgca acggacccgg cggtgcgggc ggcgctgcag agccagccgt     8940

ccggccttaa ctccacggac gactggcgcc aggtcatgga ccgcatcatg tcgctgactg     9000

cgcgcaatcc tgacgcgttc cggcagcagc cgcaggccaa ccggctctcc gcaattctgg     9060

aagcggtggt cccggcgcgc gcaaacccca cgcacgagaa ggtgctggcg atcgtaaacg     9120

cgctggccga aaacagggcc atccggcccg acgaggccgg cctggtctac gacgcgctgc     9180

ttcagcgcgt ggctcgttac aacagcggca acgtgcagac caacctggac cggctggtgg     9240

gggatgtgcg cgaggccgtg gcgcagcgtg agcgcgcgca gcagcagggc aacctgggct     9300

ccatggttgc actaaacgcc ttcctgagta cacagcccgc caacgtgccg cggggacagg     9360

aggactacac caactttgtg agcgcactgc ggctaatggt gactgagaca ccgcaaagtg     9420

aggtgtacca gtctgggcca gactattttt tccagaccag tagacaaggc ctgcagaccg     9480

taaacctgag ccaggctttc aaaaacttgc aggggctgtg gggggtgcgg gctcccacag     9540

gcgaccgcgc gaccgtgtct agcttgctga cgcccaactc gcgcctgttg ctgctgctaa     9600

tagcgccctt cacggacagt ggcagcgtgt cccgggacac atacctaggt cacttgctga     9660

cactgtaccg cgaggccata ggtcaggcgc atgtggacga gcatactttc caggagatta     9720

caagtgtcag ccgcgcgctg gggcaggagg acacgggcag cctggaggca accctaaact     9780

acctgctgac caaccggcgg cagaagatcc cctcgttgca cagtttcgca ccctttggcg     9840

catcccattc tccagtaact ttatgtccat gggcgcactc acagacctgg gccaaaacct     9900

tctctacgcc aactccgccc acgcgctaga catgactttt gaggtggatc ccatggacga     9960

gcccaccctt ctttatgttt tgtttgaagt ctttgacgtg gtccgtgtgc accggccgca    10020

ccgcggcgtc atcgaaaccg tgtacctgcg cacgcccttc tcggccggca acgccacaac    10080

ataaagaagc aagcaacatc aacaacagct gccgccatgg gctccagtga gcaggaactg    10140

aaagccattg tcaaagatct tggttgtggg ccatattttt tgggcaccta tgacaagcgc    10200

tttccaggct ttgtttctcc acacaagctc gcctgcgcca tagtcaatac ggccggtcgc    10260

gagactgggg gcgtacactg gatggccttt gcctggaacc cgcactcaaa aacatgctac    10320

ctctttgagc cctttggctt ttctgaccag cgactcaagc aggtttacca gtttgagtac    10380

gagtcactcc tgcgccgtag cgccattgct tcttcccccg accgctgtat aacgctggaa    10440

aagtccaccc aaagcgtaca ggggcccaac tcggccgcct gtggactatt ctgctgcatg    10500

tttctccacg cctttgccaa ctggccccaa actcccatgg atcacaaccc caccatgaac    10560

cttattaccg gggtacccaa ctccatgctc aacagtcccc aggtacagcc caccctgcgt    10620

cgcaaccagg aacagctcta cagcttcctg gagcgccact cgccctactt ccgcagccac    10680

agtgcgcaga ttaggagcgc cacttctttt tgtcacttga aaaacatgta aaaataatgt    10740

actagagaca ctttcaataa aggcaaatgc ttttatttgt acactctcgg gtgattattt    10800

acccccaccc ttgccgtctg cgccgtttaa aaatcaaagg ggttctgccg cgcatcgcta    10860

tgcgccactg gcagggacac gttgcgatac tggtgtttag tgctccactt aaactcaggc    10920

acaaccatcc gcggcagctc ggtgaagttt tcactccaca ggctgcgcac catcaccaac    10980

gcgtttagca ggtcgggcgc cgatatcttg aagtcgcagt tggggcctcc gccctgcgcg    11040

cgcgagttgc gatacacagg gttgcagcac tggaacacta tcagcgccgg gtggtgcacg    11100

ctggccagca cgctcttgtc ggagatcaga tccgcgtcca ggtcctccgc gttgctcagg    11160

gcgaacggag tcaactttgg tagctgcctt cccaaaaagg gcgcgtgccc aggctttgag    11220

ttgcactcgc accgtagtgg catcaaaagg tgaccgtgcc cggtctgggc gttaggatac    11280

agcgcctgca taaaagcctt gatctgctta aaagccacct gagcctttgc gccttcagag    11340

aagaacatgc cgcaagactt gccggaaaac tgattggccg gacaggccgc gtcgtgcacg    11400

cagcaccttg cgtcggtgtt ggagatctgc accacatttc ggccccaccg gttcttcacg    11460

atcttggcct tgctagactg ctccttcagc gcgcgctgcc cgttttcgct cgtcacatcc    11520

atttcaatca cgtgctcctt atttatcata atgcttccgt gtagacactt aagctcgcct    11580

tcgatctcag cgcagcggtg cagccacaac gcgcagcccg tgggctcgtg atgcttgtag    11640

gtcacctctg caaacgactg caggtacgcc tgcaggaatc gccccatcat cgtcacaaag    11700

gtcttgttgc tggtgaaggt cagctgcaac ccgcggtgct cctcgttcag ccaggtcttg    11760

catacggccg ccagagcttc cacttggtca ggcagtagtt tgaagttcgc ctttagatcg    11820

ttatccacgt ggtacttgtc catcagcgcg cgcgcagcct ccatgccctt ctcccacgca    11880

gacacgatcg gcacactcag cgggttcatc accgtaattt cactttccgc ttcgctgggc    11940

tcttcctctt cctcttgcgt ccgcatacca cgcgccactg ggtcgtcttc attcagccgc    12000

cgcactgtgc gcttacctcc tttgccatgc ttgattagca ccggtgggtt gctgaaaccc    12060

accatttgta gcgccacatc ttctctttct tcctcgctgt ccacgattac ctctggtgat    12120

ggcgggcgct cgggcttggg agaagggcgc ttctttttct tcttgggcgc aatggccaaa    12180

tccgccgccg aggtcgatgg ccgcgggctg ggtgtgcgcg gcaccagcgc gtcttgtgat    12240

gagtcttcct cgtcctcgga ctcgatacgc cgcctcatcc gcttttttgg gggcgcccgg    12300

ggaggcggcg gcgacgggga cggggacgac acgtcctcca tggttggggg acgtcgcgcc    12360

gcaccgcgtc cgcgctcggg ggtggtttcg cgctgctcct cttcccgact ggccatttcc    12420

ttctcctata ggcagaaaaa gatcatggag tcagtcgaga agaaggacag cctaaccgcc    12480

ccctctgagt tcgccaccac cgcctccacc gatgccgcca acgcgcctac caccttcccc    12540

gtcgaggcac ccccgcttga ggaggaggaa gtgattatcg agcaggaccc aggttttgta    12600

agcgaagacg acgaggaccg ctcagtacca acagaggata aaaagcaaga ccaggacaac    12660

gcagaggcaa acgaggaaca agtcgggcgg ggggacgaaa ggcatggcga ctacctagat    12720

gtgggagacg acgtgctgtt gaagcatctg cagcgccagt gcgccattat ctgcgacgcg    12780

ttgcaagagc gcagcgatgt gcccctcgcc atagcggatg tcagccttgc ctacgaacgc    12840

cacctattct caccgcgcgt accccccaaa cgccaagaaa acggcacatg cgagcccaac    12900

ccgcgcctca acttctaccc cgtatttgcc gtgccagagg tgcttgccac ctatcacatc    12960

tttttccaaa actgcaagat acccctatcc tgccgtgcca accgcagccg agcggacaag    13020

cagctggcct tgcggcaggg cgctgtcata cctgatatcg cctcgctcaa cgaagtgcca    13080

aaaatctttg agggtcttgg acgcgacgag aagcgcgcgg caaacgctct gcaacaggaa    13140

aacagcgaaa atgaaagtca ctctggagtg ttggtggaac tcgagggtga caacgcgcgc    13200

ctagccgtac taaaacgcag catcgaggtc acccactttg cctacccggc acttaaccta    13260

ccccccaagg tcatgagcac agtcatgagt gagctgatcg tgcgccgtgc gcagcccctg    13320

gagagggatg caaatttgca agaacaaaca gaggagggcc tacccgcagt tggcgacgag    13380

cagctagcgc gctggcttca aacgcgcgag cctgccgact tggaggagcg acgcaaacta    13440

atgatggccg cagtgctcgt taccgtggag cttgagtgca tgcagcggtt ctttgctgac    13500

ccggagatgc agcgcaagct agaggaaaca ttgcactaca cctttcgaca gggctacgta    13560

cgccaggcct gcaagatctc caacgtggag ctctgcaacc tggtctccta ccttggaatt    13620

ttgcacgaaa accgccttgg gcaaaacgtg cttcattcca cgctcaaggg cgaggcgcgc    13680

cgcgactacg tccgcgactg cgtttactta tttctatgct acacctggca gacggccatg    13740

ggcgtttggc agcagtgctt ggaggagtgc aacctcaagg agctgcagaa actgctaaag    13800

caaaacttga aggacctatg gacggccttc aacgagcgct ccgtggccgc gcacctggcg    13860

gacatcattt tccccgaacg cctgcttaaa accctgcaac agggtctgcc agacttcacc    13920

agtcaaagca tgttgcagaa ctttaggaac tttatcctag agcgctcagg aatcttgccc    13980

gccacctgct gtgcacttcc tagcgacttt gtgcccatta agtaccgcga atgccctccg    14040

ccgctttggg gccactgcta ccttctgcag ctagccaact accttgccta ccactctgac    14100

ataatggaag acgtgagcgg tgacggtcta ctggagtgtc actgtcgctg caacctatgc    14160

accccgcacc gctccctggt ttgcaattcg cagctgctta acgaaagtca aattatcggt    14220

acctttgagc tgcagggtcc ctcgcctgac gaaaagtccg cggctccggg gttgaaactc    14280

actccggggc tgtggacgtc ggcttacctt cgcaaatttg tacctgagga ctaccacgcc    14340

cacgagatta ggttctacga agaccaatcc cgcccgccat atgcggagct taccgcctgc    14400

gtcattaccc agggccacat tcttggccaa ttgcaagcca tcaacaaagc ccgccaagag    14460

tttctgctac gaaagggacg gggggtttac ttggaccccc agtccggcga ggagctcaac    14520

ccaatccccc cgccgccgca gccctatcag cagcagccgc gggcccttgc ttcccaggat    14580

ggcacccaaa aagaagctgc agctgccgcc gccacccacg gacgaggagg aatactggga    14640

cagtcaggca gaggaggttt tggacgagga ggaggaggac atgatggaag actgggagag    14700

cctagacgag gaagcttccg aggtcgaaga ggtgtcagac gaaacaccgt caccctcggt    14760

cgcattcccc tcgccggcgc cccagaaatc ggcaaccggt tccagcatgg ctacaacctc    14820

cgctcctcag gcgccgccgg cactgcccgt tcgccgaccc aaccgtagat gggacaccac    14880

tggaaccagg gccggtaagt ccaagcagcc gccgccgtta gcccaagagc aacaacagcg    14940

ccaaggctac cgctcatggc gcgggcacaa gaacgccata gttgcttgct tgcaagactg    15000

tgggggcaac atctccttcg cccgccgctt tcttctctac catcacggcg tggccttccc    15060

ccgtaacatc ctgcattact accgtcatct ctacagccca tactgcaccg gcggcagcgg    15120

cagcaacagc agcggccaca cagaagcaaa ggcgaccgga tagcaagact ctgacaaagc    15180

ccaagaaatc cacagcggcg gcagcagcag gaggaggagc gctgcgtctg gcgcccaacg    15240

aacccgtatc gacccgcgag cttagaaaca ggatttttcc cactctgtat gctatatttc    15300

aacagagcag gggccaagaa caagagctga aaataaaaaa caggtctctg cgatccctca    15360

cccgcagctg cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg gaagacgcgg    15420

aggctctctt cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc gccctttctc    15480

aaatttaagc gcgaaaacta cgtcatctcc agcggccaca cccggcgcca gcacctgttg    15540

tcagcgccat tatgagcaag gaaattccca cgccctacat gtggagttac cagccacaaa    15600

tgggacttgc ggctggagct gcccaagact actcaacccg aataaactac atgagcgcgg    15660

gaccccacat gatatcccgg gtcaacggaa tacgcgccca ccgaaaccga attctctcgg    15720

aacaggcggc tattaccacc acacctcgta ataaccttaa tccccgtagt tggcccgctg    15780

ccctggtgta ccaggaaagt cccgctccca ccactgtggt acttcccaga gacgcccagg    15840

ccgaagttca gatgactaac tcaggggcgc agcttgcggg cggctttcgt cacagggtgc    15900

ggtcgcccgg gcagggtata actcacctga caatcagagg gcgaggtatt cagctcaacg    15960

acgagtcggt gagctcctcg cttggtctcc gtccggacgg gacatttcag atcggcggcg    16020

ccggccgctc ttcattcacg cctcgtcagg caatcctaac tctgcagacc tcgtcctctg    16080

agccgcgctc tggaggcatt ggaactctgc aatttattga ggagtttgtg ccatcggtct    16140

actttaaccc cttctcggga cctcccggcc actatccgga tcaatttatt cctaactttg    16200

acgcggtaaa ggactcggcg gacggctacg actgaatgtt aagtggagag gcagagcaac    16260

tgcgcctgaa acacctggtc cactgtcgcc gccacaagtg ctttgcccgc gactccggtg    16320

agttttgcta ctttgaattg cccgaggatc atatcgaggg cccggcgcac ggcgtccggc    16380

ttaccgccca gggagagctt gcccgtagcc tgattcggga gtttacccag cgccccctgc    16440

tagttgagcg ggacagggga ccctgtgttc tcactgtgat ttgcaactgt cctaaccctg    16500

gattacatca agatcctcta gttaattaac tagagtaccc ggggatctta ttccctttaa    16560

ctaataaaaa aaaataataa agcatcactt acttaaaatc agttagcaaa tttctgtcca    16620

gtttattcag cagcacctcc ttgccctcct cccagctctg gtattgcagc ttcctcctgg    16680

ctgcaaactt tctccacaat ctaaatggaa tgtcagtttc ctcctgttcc tgtccatccg    16740

cacccactat cttcatgttg ttgcagatga agcgcgcaag accgtctgaa gataccttca    16800

accccgtgta tccatatgac acggaaaccg gtcctccaac tgtgcctttt cttactcctc    16860

cctttgtatc ccccaatggg tttcaagaga gtccccctgg ggtactctct ttgcgcctat    16920

ccgaacctct agttacctcc aatggcatgc ttgcgctcaa aatgggcaac ggcctctctc    16980

tggacgaggc cggcaacctt acctcccaaa atgtaaccac tgtgagccca cctctcaaaa    17040

aaaccaagtc aaacataaac ctggaaatat ctgcacccct cacagttacc tcagaagccc    17100

taactgtggc tgccgccgca cctctaatgg tcgcgggcaa cacactcacc atgcaatcac    17160

aggccccgct aaccgtgcac gactccaaac ttagcattgc cacccaagga cccctcacag    17220

tgtcagaagg aaagctagcc ctgcaaacat caggccccct caccaccacc gatagcagta    17280

cccttactat cactgcctca ccccctctaa ctactgccac tggtagcttg ggcattgact    17340

tgaaagagcc catttataca caaaatggaa aactaggact aaagtacggg gctcctttgc    17400

atgtaacaga cgacctaaac actttgaccg tagcaactgg tccaggtgtg actattaata    17460

atacttcctt gcaaactaaa gttactggag ccttgggttt tgattcacaa ggcaatatgc    17520

aacttaatgt agcaggagga ctaaggattg attctcaaaa cagacgcctt atacttgatg    17580

ttagttatcc gtttgatgct caaaaccaac taaatctaag actaggacag ggccctcttt    17640

ttataaactc agcccacaac ttggatatta actacaacaa aggcctttac ttgtttacag    17700

cttcaaacaa ttccaaaaag cttgaggtta acctaagcac tgccaagggg ttgatgtttg    17760

acgctacagc catagccatt aatgcaggag atgggcttga atttggttca cctaatgcac    17820

caaacacaaa tcccctcaaa acaaaaattg gccatggcct agaatttgat tcaaacaagg    17880

ctatggttcc taaactagga actggcctta gttttgacag cacaggtgcc attacagtag    17940

gaaacaaaaa taatgataag ctaactttgt ggaccacacc agctccatct cctaactgta    18000

gactaaatgc agagaaagat gctaaactca ctttggtctt aacaaaatgt ggcagtcaaa    18060

tacttgctac agtttcagtt ttggctgtta aaggcagttt ggctccaata tctggaacag    18120

ttcaaagtgc tcatcttatt ataagatttg acgaaaatgg agtgctacta aacaattcct    18180

tcctggaccc agaatattgg aactttagaa atggagatct tactgaaggc acagcctata    18240

caaacgctgt tggatttatg cctaacctat cagcttatcc aaaatctcac ggtaaaactg    18300

ccaaaagtaa cattgtcagt caagtttact taaacggaga caaaactaaa cctgtaacac    18360

taaccattac actaaacggt acacaggaaa caggagacac aactccaagt gcatactcta    18420

tgtcattttc atgggactgg tctggccaca actacattaa tgaaatattt gccacatcct    18480

cttacacttt ttcatacatt gcccaagaat aaagaatcgt ttgtgttatg tttcaacgtg    18540

tttatttttc aattgcagaa aatttcaagt catttttcat tcagtagtat agccccacca    18600

ccacatagct tatacagatc accgtacctt aatcaaactc acagaaccct agtattcaac    18660

ctgccacctc cctcccaaca cacagagtac acagtccttt ctccccggct ggccttaaaa    18720

agcatcatat catgggtaac agacatattc ttaggtgtta tattccacac ggtttcctgt    18780

cgagccaaac gctcatcagt gatattaata aactccccgg gcagctcact taagttcatg    18840

tcgctgtcca gctgctgagc cacaggctgc tgtccaactt gcggttgctt aacgggcggc    18900

gaaggagaag tccacgccta catgggggta gagtcataat cgtgcatcag gatagggcgg    18960

tggtgctgca gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct gcaggaatac    19020

aacatggcag tggtctcctc agcgatgatt cgcaccgccc gcagcataag gcgccttgtc    19080

ctccgggcac agcagcgcac cctgatctca cttaaatcag cacagtaact gcagcacagc    19140

accacaatat tgttcaaaat cccacagtgc aaggcgctgt atccaaagct catggcgggg    19200

accacagaac ccacgtggcc atcataccac aagcgcaggt agattaagtg gcgacccctc    19260

ataaacacgc tggacataaa cattacctct tttggcatgt tgtaattcac cacctcccgg    19320

taccatataa acctctgatt aaacatggcg ccatccacca ccatcctaaa ccagctggcc    19380

aaaacctgcc cgccggctat acactgcagg gaaccgggac tggaacaatg acagtggaga    19440

gcccaggact cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt ggcacaacac    19500

aggcacacgt gcatacactt cctcaggatt acaagctcct cccgcgttag aaccatatcc    19560

cagggaacaa cccattcctg aatcagcgta aatcccacac tgcagggaag acctcgcacg    19620

taactcacgt tgtgcattgt caaagtgtta cattcgggca gcagcggatg atcctccagt    19680

atggtagcgc gggtttctgt ctcaaaagga ggtagacgat ccctactgta cggagtgcgc    19740

cgagacaacc gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc ggacgtagtc    19800

atatttcctg aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc tccggtctcg    19860

ccgcttagat cgctctgtgt agtagttgta gtatatccac tctctcaaag catccaggcg    19920

ccccctggct tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga taacatccac    19980

caccgcagaa taagccacac ccagccaacc tacacattcg ttctgcgagt cacacacggg    20040

aggagcggga agagctggaa gaaccatgtt ttttttttta ttccaaaaga ttatccaaaa    20100

cctcaaaatg aagatctatt aagtgaacgc gctcccctcc ggtggcgtgg tcaaactcta    20160

cagccaaaga acagataatg gcatttgtaa gatgttgcac aatggcttcc aaaaggcaaa    20220

cggccctcac gtccaagtgg acgtaaaggc taaacccttc agggtgaatc tcctctataa    20280

acattccagc accttcaacc atgcccaaat aattctcatc tcgccacctt ctcaatatat    20340

ctctaagcaa atcccgaata ttaagtccgg ccattgtaaa aatctgctcc agagcgccct    20400

ccaccttcag cctcaagcag cgaatcatga ttgcaaaaat tcaggttcct cacagacctg    20460

tataagattc aaaagcggaa cattaacaaa aataccgcga tcccgtaggt cccttcgcag    20520

ggccagctga acataatcgt gcaggtctgc acggaccagc gcggccactt ccccgccagg    20580

aaccatgaca aaagaaccca cactgattat gacacgcata ctcggagcta tgctaaccag    20640

cgtagccccg atgtaagctt gttgcatggg cggcgatata aaatgcaagg tgctgctcaa    20700

aaaatcaggc aaagcctcgc gcaaaaaaga aagcacatcg tagtcatgct catgcagata    20760

aaggcaggta agctccggaa ccaccacaga aaaagacacc atttttctct caaacatgtc    20820

tgcgggtttc tgcataaaca caaaataaaa taacaaaaaa acatttaaac attagaagcc    20880

tgtcttacaa caggaaaaac aacccttata agcataagac ggactacggc catgccggcg    20940

tgaccgtaaa aaaactggtc accgtgatta aaaagcacca ccgacagctc ctcggtcatg    21000

tccggagtca taatgtaaga ctcggtaaac acatcaggtt gattcacatc ggtcagtgct    21060

aaaaagcgac cgaaatagcc cgggggaata catacccgca ggcgtagaga caacattaca    21120

gcccccatag gaggtataac aaaattaata ggagagaaaa acacataaac acctgaaaaa    21180

ccctcctgcc taggcaaaat agcaccctcc cgctccagaa caacatacag cgcttccaca    21240

gcggcagcca taacagtcag ccttaccagt aaaaaagaaa acctattaaa aaaacaccac    21300

tcgacacggc accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta    21360

tatataggac taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc    21420

acgcgaacct acgcccagaa acgaaagcca aaaaacccac aacttcctca aatcgtcact    21480

tccgttttcc cacgttacgt aacttcccat tttaagaaaa ctacaattcc caacacatac    21540

aagttactcc gccctaaaac ctacgtcacc cgccccgttc ccacgccccg cgccacgtca    21600

caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat attattgatg    21660

atttattttg gattgaagcc aatatgataa tgagggggtg gagtttgtga cgtggcgcgg    21720

ggcgtgggaa cggggcgggt gacgtagtag tgtggcggaa gtgtgatgtt gcaagtgtgg    21780

cggaacacat gtaagcgacg gatgtggcaa aagtgacgtt tttggtgtgc gccggatcca    21840

caggacgggt gtggtcgcca tgatcgcgta gtcgatagtg gctccaagta gcgaagcgag    21900

caggactggg cggcggccaa agcggtcgga cagtgctccg agaacgggtg cgcatagaaa    21960

ttgcatcaac gcatatagcg ctagcagcac gccatagtga ctggcgatgc tgtcggaatg    22020

gacgatatcc cgcaagaggc ccggcagtac cggcataacc aagcctatgc ctacagcatc    22080

cagggtgacg gtgccgagga tgacgatgag cgcattgtta gatttcatac acggtgcctg    22140

actgcgttag caatttaact gtgataaact accgcattaa agcttatcga attcgtaatc    22200

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg    22260

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat    22320

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg    22380

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgc                      22423


<210>  3
<211>  10365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV2

<400>  3
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagacgc ttgcactgcc tgcgatctgg tcaatgtgga     1980

tttggatgac tgcatctttg aacaataaat gatttaaatc aggtatggct gccgatggtt     2040

atcttccaga ttggctcgag gacactctct ctgaaggaat aagacagtgg tggaagctca     2100

aacctggccc accaccacca aagcccgcag agcggcataa ggacgacagc aggggtcttg     2160

tgcttcctgg gtacaagtac ctcggaccct tcaacggact cgacaaggga gagccggtca     2220

acgaggcaga cgccgcggcc ctcgagcacg acaaagccta cgaccggcag ctcgacagcg     2280

gagacaaccc gtacctcaag tacaaccacg ccgacgcgga gtttcaggag cgccttaaag     2340

aagatacgtc ttttgggggc aacctcggac gagcagtctt ccaggcgaaa aagagggttc     2400

ttgaacctct gggcctggtt gaggaacctg ttaagacggc tccgggaaaa aagaggccgg     2460

tagagcactc tcctgtggag ccagactcct cctcgggaac cggaaaggcg ggccagcagc     2520

ctgcaagaaa aagattgaat tttggtcaga ctggagacgc agactcagta cctgaccccc     2580

agcctctcgg acagccacca gcagccccct ctggtctggg aactaatacg atggctacag     2640

gcagtggcgc accaatggca gacaataacg agggcgccga cggagtgggt aattcctcgg     2700

gaaattggca ttgcgattcc acatggatgg gcgacagagt catcaccacc agcacccgaa     2760

cctgggccct gcccacctac aacaaccacc tctacaaaca aatttccagc caatcaggag     2820

cctcgaacga caatcactac tttggctaca gcaccccttg ggggtatttt gacttcaaca     2880

gattccactg ccacttttca ccacgtgact ggcaaagact catcaacaac aactggggat     2940

tccgacccaa gagactcaac ttcaagctct ttaacattca agtcaaagag gtcacgcaga     3000

atgacggtac gacgacgatt gccaataacc ttaccagcac ggttcaggtg tttactgact     3060

cggagtacca gctcccgtac gtcctcggct cggcgcatca aggatgcctc ccgccgttcc     3120

cagcagacgt cttcatggtg ccacagtatg gatacctcac cctgaacaac gggagtcagg     3180

cagtaggacg ctcttcattt tactgcctgg agtactttcc ttctcagatg ctgcgtaccg     3240

gaaacaactt taccttcagc tacacttttg aggacgttcc tttccacagc agctacgctc     3300

acagccagag tctggaccgt ctcatgaatc ctctcatcga ccagtacctg tattacttga     3360

gcagaacaaa cactccaagt ggaaccacca cgcagtcaag gcttcagttt tctcaggccg     3420

gagcgagtga cattcgggac cagtctagga actggcttcc tggaccctgt taccgccagc     3480

agcgagtatc aaagacatct gcggataaca acaacagtga atactcgtgg actggagcta     3540

ccaagtacca cctcaatggc agagactctc tggtgaatcc gggcccggcc atggcaagcc     3600

acaaggacga tgaagaaaag ttttttcctc agagcggggt tctcatcttt gggaagcaag     3660

gctcagagaa aacaaatgtg gacattgaaa aggtcatgat tacagacgaa gaggaaatca     3720

ggacaaccaa tcccgtggct acggagcagt atggttctgt atctaccaac ctccagagag     3780

gcaacagaca agcagctacc gcagatgtca acacacaagg cgttcttcca ggcatggtct     3840

ggcaggacag agatgtgtac cttcaggggc ccatctgggc aaagattcca cacacggacg     3900

gacattttca cccctctccc ctcatgggtg gattcggact taaacaccct cctccacaga     3960

ttctcatcaa gaacaccccg gtacctgcga atccttcgac caccttcagt gcggcaaagt     4020

ttgcttcctt catcacacag tactccacgg gacaggtcag cgtggagatc gagtgggagc     4080

tgcagaagga aaacagcaaa cgctggaatc ccgaaattca gtacacttcc aactacaaca     4140

agtctgttaa tgtggacttt actgtggaca ctaatggcgt gtattcagag cctcgcccca     4200

ttggcaccag atacctgact cgtaatctgt aattgcttgt taatcaataa accgtttaat     4260

tcgtttcagt tgaactttgg tctctgcgta tttctttctt atctagtttc catatgcatg     4320

tagataagta gcatggcggg ttaatcatta actaaccggt acctctagaa ctatagctag     4380

cgatgaccct gctgattggt tcgctgacca tttccgggtg cgggacggcg ttaccagaaa     4440

ctcagaaggt tcgtccaacc aaaccgactc tgacggcagt ttacgagaga gatgataggg     4500

tctgcttcag taagccagat gctacacaat taggcttgta catattgtcg ttagaacgcg     4560

gctacaatta atacataacc ttatgtatca tacacatacg atttaggtga cactatagaa     4620

tacacggaat taattcttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc     4680

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc     4740

gcgcagagag ggagtggcca actccatcac taggggttcc ttacgtagga cgtcccctgc     4800

aggcagggag gggtggagtc gtgacgtaaa gatctgatat catcgatcgc gatgcattaa     4860

ttaagcggcc gaggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa     4920

cccctcagtt cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac     4980

aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac     5040

acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg     5100

cccatgccac ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt     5160

tgtcctggcg tggtttaggt agtgtgagag gggtacccgg ggatcttgct accagtggaa     5220

cagccactaa ggattctgca gtgagagcag agggccagct aagtggtact ctcccagaga     5280

ctgtctgact cacgccaccc cctccacctt ggacacagga cgctgtggtt tctgagccag     5340

gtacaatgac tcctttcggt aagtgcagtg gaagctgtac actgcccagg caaagcgtcc     5400

gggcagcgta ggcgggcgac tcagatccca gccagtggac ttagcccctg tttgctcctc     5460

cgataactgg ggtgaccttg gttaatattc accagcagcc tcccccgttg cccctctgga     5520

tccactgctt aaatacggac gaggacaggg ccctgtctcc tcagcttcag gcaccaccac     5580

tgacctggga cagtgaatga tccccctgat ctgcggcctc gacggtatcg ataagcttga     5640

tatcgaattc tagtcgtcga ccactttcac aatctgctag caaaggttgc caccatgcag     5700

cgcgtgaaca tgattatggc cgagagccct ggcctgatca ccatctgcct gctgggctac     5760

ctgctgagcg ccgagtgtac aggtttgttt ccttttttaa aatacattga gtatgcttgc     5820

cttttagata tagaaatatc tgatgctgtc ttcttcacta aattttgatt acatgatttg     5880

acagcaatat tgaagagtct aacagccagc acgcaggttg gtaagtactg gttctttgtt     5940

agctaggttt tcttcttctt catttttaaa actaaataga tcgacaatgc ttatgatgca     6000

tttatgttta ataaacactg ttcagttcat gatttggtca tgtaattcct gttagaaaac     6060

attcatctcc ttggtttaaa aaaattaaaa gtgggaaaac aaagaaatag cagaatatag     6120

tgaaaaaaaa taaccacatt atttttgttt ggacttacca ctttgaaatc aaaatgggaa     6180

acaaaagcac aaacaatggc cttatttaca caaaaagtct gattttaaga tatatgacat     6240

ttcaaggttt cagaagtatg taatgaggtg tgtctctaat tttttaaatt atatatcttc     6300

aatttaaagt tttagttaaa acataaagat taacctttca ttagcaagct gttagttatc     6360

accaaagctt ttcatggatt aggaaaaaat cattttgtct ctatgtcaaa catcttggag     6420

ttgatatttg gggaaacaca atactcagtt gagttcccta ggggagaaaa gcaagcttaa     6480

gaattgacat aaagagtagg aagttagcta atgcaacata tatcactttg ttttttcaca     6540

actacagtga ctttatgtat ttcccagagg aaggcataca gggaagaaat tatcccattt     6600

ggacaaacag catgttctca caggaagcat ttatcacact tacttgtcaa ctttctagaa     6660

tcaaatctag tagctgacag taccaggatc aggggtgcca accctaagca cccccagaaa     6720

gctgactggc cctgtggttc ccactccaga catgatgtca gctgtgaaat cgacgtcgct     6780

ggaccataat taggcttctg ttcttcagga gacatttgtt caaagtcatt tgggcaacca     6840

tattctgaaa acagcccagc cagggtgatg gatcactttg caaagatcct caatgagcta     6900

ttttcaagtg atgacaaagt gtgaagttaa ccgctcattt gagaactttc tttttcatcc     6960

aaagtaaatt caaatatgat tagaaatctg accttttatt actggaattc tcttgactaa     7020

aagtaaaatt gaattttaat tcctaaatct ccatgtgtat acagtactgt gggaacatca     7080

cagattttgg ctccatgccc taaagagaaa ttggctttca gattatttgg attaaaaaca     7140

aagactttct taagagatgt aaaattttca tgatgttttc ttttttgcta aaactaaaga     7200

attattcttt tacatttcag tgttcctgga ccacgagaac gccaacaaga tcctgaacag     7260

acccaagaga tacaacagcg gcaagctgga agagttcgtg cagggcaacc tggaacgcga     7320

gtgcatggaa gagaagtgca gcttcgaaga ggccagagag gtgttcgaga acaccgagag     7380

aaccaccgag ttctggaagc agtacgtgga cggcgaccag tgcgagagca acccttgtct     7440

gaacggcggc agctgcaagg acgacatcaa cagctacgag tgctggtgcc ccttcggctt     7500

cgagggcaag aactgcgagc tggacgtgac ctgcaacatc aagaacggca gatgcgagca     7560

gttctgcaag aacagcgccg acaacaaggt cgtgtgctcc tgcaccgagg gctacagact     7620

ggccgagaac cagaagtcct gcgagcccgc tgtgcctttc ccatgcggaa gagtgtccgt     7680

gtcccagacc agcaagctga ccagagccga gacagtgttc cccgacgtgg actacgtgaa     7740

cagcaccgag gccgagacaa tcctggacaa catcacccag agcacccagt ccttcaacga     7800

cttcaccaga gtcgtgggcg gcgaggatgc taagcctggc cagttcccgt ggcaggtggt     7860

gctgaacgga aaggtggacg ccttctgcgg cggctccatc gtgaacgaga agtggatcgt     7920

gacagccgcc cactgcgtgg aaaccggcgt gaagatcaca gtggtggccg gcgagcacaa     7980

catcgaggaa accgagcaca cagagcagaa aagaaacgtg atcaggatca tcccccacca     8040

caactacaac gccgccatca acaagtacaa ccacgatatc gccctgctgg aactggacga     8100

gcccctggtg ctgaatagct acgtgacccc catctgtatc gccgacaaag agtacaccaa     8160

catctttctg aagttcggca gcggctacgt gtccggctgg ggcagagtgt ttcacaaggg     8220

cagatccgct ctggtgctgc agtacctgag agtgcctctg gtggacagag ccacctgtct     8280

gagaagcacc aagttcacca tctacaacaa catgttctgc gctggcttcc acgagggcgg     8340

cagagactct tgtcagggcg attctggcgg ccctcacgtg acagaggtgg aaggcaccag     8400

ctttctgacc ggcatcatca gctggggcga ggaatgcgcc atgaagggga agtacggcat     8460

ctacaccaag gtgtccagat acgtgaactg gatcaaagaa aagaccaagc tgacataatg     8520

aaagatggat ttccaaggtt aattcattgg aattgaaaat taacagcccc cccccccccc     8580

ccctgcagat ctcgagccga attcctgcag cccgggggat cagcctcgac tgtgccttct     8640

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     8700

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     8760

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     8820

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     8880

ggctcgagat ccactagact agtgtacacg cgtgatatca gatctgttac gtaaggaacc     8940

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg     9000

ggcaaagccc gggcggcctc agtgagcgag cgagcgcgca gagagggagt ggccaacttt     9060

ttgcaaaagc ctaggcctcc aaaaaagcct cctcactact tctggaatag ctcagaggcc     9120

gaggcggcct cggcctctgc ataaataaaa aaaattagtc agccatgggg cggagaatgg     9180

gcggaactgg gcggagttag gggcgggatg ggcggagtta ggggcgggac tatggttgct     9240

gactaattga gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca     9300

cacctggttg ctgactaatt gagatgcatg ctttgcatac ttctgcctgc tggggagcct     9360

ggggactttc cacaccctaa ctgacacaca ttccacagct gcattaatga atcggccaac     9420

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     9480

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     9540

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     9600

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     9660

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     9720

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     9780

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct     9840

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     9900

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     9960

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg    10020

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag    10080

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt    10140

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta    10200

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc    10260

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca    10320

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaa                    10365


<210>  4
<211>  10332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV5

<400>  4
agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta       60

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc      120

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg      180

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga      240

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt      300

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt      360

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc      420

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc      480

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca      540

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag      600

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg      660

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa      720

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa      780

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga      840

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga      900

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg      960

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     1020

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa     1080

aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc     1140

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     1200

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct taactatgcg     1260

gcatcagagc agattgtact gagagtgcac cattcgacgc tctcccttat gcgactcctg     1320

cattaggaag cagcccagta gtaggttgag gccgttgagc accgccgccg caaggaatgg     1380

tgcatgcaag gagatggcgc ccaacagtcc cccggccacg gggcctgcca ccatacccac     1440

gccgaaacaa gcgctcatga gcccgaagtg gcgagcccga tcttccccat cggtgatgtc     1500

ggcgatatag gcgccagcaa ccgcacctgt ggcgccggtg ggtcaccaag caggaagtca     1560

aagacttttt ccggtgggca aaggatcacg tggttgaggt ggagcatgaa ttctacgtca     1620

aaaagggtgg agccaagaaa agacccgccc ccagtgacgc agatataagt gagcccaaac     1680

gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc ggaagcttcg atcaactacg     1740

cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat gaatctgatg ctgtttccct     1800

gcagacaatg cgagagaatg aatcagaatt caaatatctg cttcactcac ggacagaaag     1860

actgtttaga gtgctttccc gtgtcagaat ctcaacccgt ttctgtcgtc aaaaaggcgt     1920

atcagaaact gtgctacatt catcatatca tgggaaaggt gccagacgct tgcactgcct     1980

gcgatctggt caatgtggat ttggatgact gcatctttga acaataaatg atttaaatca     2040

ggtatgtctt ttgttgatca ccctccagat tggttggaag aagttggtga aggtcttcgc     2100

gagtttttgg gccttgaagc gggcccaccg aaaccaaaac ccaatcagca gcatcaagat     2160

caagcccgtg gtcttgtgct gcctggttat aactatctcg gacccggaaa cggtctcgat     2220

cgaggagagc ctgtcaacag ggcagacgag gtcgcgcgag agcacgacat ctcgtacaac     2280

gagcagcttg aggcgggaga caacccctac ctcaagtaca accacgcgga cgccgagttt     2340

caggagaagc tcgccgacga cacatccttc gggggaaacc tcggaaaggc agtctttcag     2400

gccaagaaaa gggttctcga accttttggc ctggttgaag agggtgctaa gacggcccct     2460

accggaaagc ggatagacga ccactttcca aaaagaaaga aggctcggac cgaagaggac     2520

tccaagcctt ccacctcgtc agacgccgaa gctggaccca gcggatccca gcagctgcaa     2580

atcccagccc aaccagcctc aagtttggga gctgatacaa tgtctgcggg aggtggcggc     2640

ccattgggcg acaataacca aggtgccgat ggagtgggca atgcctcggg agattggcat     2700

tgcgattcca cgtggatggg ggacagagtc gtcaccaagt ccacccgaac ctgggtgctg     2760

cccagctaca acaaccacca gtaccgagag atcaaaagcg gctccgtcga cggaagcaac     2820

gccaacgcct actttggata cagcaccccc tgggggtact ttgactttaa ccgcttccac     2880

agccactgga gcccccgaga ctggcaaaga ctcatcaaca actactgggg cttcagaccc     2940

cggtccctca gagtcaaaat cttcaacatt caagtcaaag aggtcacggt gcaggactcc     3000

accaccacca tcgccaacaa cctcacctcc accgtccaag tgtttacgga cgacgactac     3060

cagctgccct acgtcgtcgg caacgggacc gagggatgcc tgccggcctt ccctccgcag     3120

gtctttacgc tgccgcagta cggttacgcg acgctgaacc gcgacaacac agaaaatccc     3180

accgagagga gcagcttctt ctgcctagag tactttccca gcaagatgct gagaacgggc     3240

aacaactttg agtttaccta caactttgag gaggtgccct tccactccag cttcgctccc     3300

agtcagaacc tgttcaagct ggccaacccg ctggtggacc agtacttgta ccgcttcgtg     3360

agcacaaata acactggcgg agtccagttc aacaagaacc tggccgggag atacgccaac     3420

acctacaaaa actggttccc ggggcccatg ggccgaaccc agggctggaa cctgggctcc     3480

ggggtcaacc gcgccagtgt cagcgccttc gccacgacca ataggatgga gctcgagggc     3540

gcgagttacc aggtgccccc gcagccgaac ggcatgacca acaacctcca gggcagcaac     3600

acctatgccc tggagaacac tatgatcttc aacagccagc cggcgaaccc gggcaccacc     3660

gccacgtacc tcgagggcaa catgctcatc accagcgaga gcgagacgca gccggtgaac     3720

cgcgtggcgt acaacgtcgg cgggcagatg gccaccaaca accagagctc caccactgcc     3780

cccgcgaccg gcacgtacaa cctccaggaa atcgtgcccg gcagcgtgtg gatggagagg     3840

gacgtgtacc tccaaggacc catctgggcc aagatcccag agacgggggc gcactttcac     3900

ccctctccgg ccatgggcgg attcggactc aaacacccac cgcccatgat gctcatcaag     3960

aacacgcctg tgcccggaaa tatcaccagc ttctcggacg tgcccgtcag cagcttcatc     4020

acccagtaca gcaccgggca ggtcaccgtg gagatggagt gggagctcaa gaaggaaaac     4080

tccaagaggt ggaacccaga gatccagtac acaaacaact acaacgaccc ccagtttgtg     4140

gactttgccc cggacagcac cggggaatac agaaccacca gacctatcgg aacccgatac     4200

cttacccgac ccctttaatt gcttgttaat caataaaccg tttaattcgt ttcagttgaa     4260

ctttggtctc tgcgtatttc tttcttatct agtttccata tgcatgtaga taagtagcat     4320

ggcgggttaa tcattaacta accggtacct ctagaactat agctagcgat gaccctgctg     4380

attggttcgc tgaccatttc cgggtgcggg acggcgttac cagaaactca gaaggttcgt     4440

ccaaccaaac cgactctgac ggcagtttac gagagagatg atagggtctg cttcagtaag     4500

ccagatgcta cacaattagg cttgtacata ttgtcgttag aacgcggcta caattaatac     4560

ataaccttat gtatcataca catacgattt aggtgacact atagaataca cggaattaat     4620

tcttggccac tccctctctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg     4680

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag     4740

tggccaactc catcactagg ggttccttac gtaggacgtc ccctgcaggc agggaggggt     4800

ggagtcgtga cgtaaagatc tgatatcatc gatcgcgatg cattaattaa gcggccgagg     4860

ctcagaggca cacaggagtt tctgggctca ccctgccccc ttccaacccc tcagttccca     4920

tcctccagca gctgtttgtg tgctgcctct gaagtccaca ctgaacaaac ttcagcctac     4980

tcatgtccct aaaatgggca aacattgcaa gcagcaaaca gcaaacacac agccctccct     5040

gcctgctgac cttggagctg gggcagaggt cagagacctc tctgggccca tgccacctcc     5100

aacatccact cgaccccttg gaatttcggt ggagaggagc agaggttgtc ctggcgtggt     5160

ttaggtagtg tgagaggggt acccggggat cttgctacca gtggaacagc cactaaggat     5220

tctgcagtga gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg     5280

ccaccccctc caccttggac acaggacgct gtggtttctg agccaggtac aatgactcct     5340

ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg     5400

ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg     5460

accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat     5520

acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt     5580

gaatgatccc cctgatctgc ggcctcgacg gtatcgataa gcttgatatc gaattctagt     5640

cgtcgaccac tttcacaatc tgctagcaaa ggttgccacc atgcagcgcg tgaacatgat     5700

tatggccgag agccctggcc tgatcaccat ctgcctgctg ggctacctgc tgagcgccga     5760

gtgtacaggt ttgtttcctt ttttaaaata cattgagtat gcttgccttt tagatataga     5820

aatatctgat gctgtcttct tcactaaatt ttgattacat gatttgacag caatattgaa     5880

gagtctaaca gccagcacgc aggttggtaa gtactggttc tttgttagct aggttttctt     5940

cttcttcatt tttaaaacta aatagatcga caatgcttat gatgcattta tgtttaataa     6000

acactgttca gttcatgatt tggtcatgta attcctgtta gaaaacattc atctccttgg     6060

tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga atatagtgaa aaaaaataac     6120

cacattattt ttgtttggac ttaccacttt gaaatcaaaa tgggaaacaa aagcacaaac     6180

aatggcctta tttacacaaa aagtctgatt ttaagatata tgacatttca aggtttcaga     6240

agtatgtaat gaggtgtgtc tctaattttt taaattatat atcttcaatt taaagtttta     6300

gttaaaacat aaagattaac ctttcattag caagctgtta gttatcacca aagcttttca     6360

tggattagga aaaaatcatt ttgtctctat gtcaaacatc ttggagttga tatttgggga     6420

aacacaatac tcagttgagt tccctagggg agaaaagcaa gcttaagaat tgacataaag     6480

agtaggaagt tagctaatgc aacatatatc actttgtttt ttcacaacta cagtgacttt     6540

atgtatttcc cagaggaagg catacaggga agaaattatc ccatttggac aaacagcatg     6600

ttctcacagg aagcatttat cacacttact tgtcaacttt ctagaatcaa atctagtagc     6660

tgacagtacc aggatcaggg gtgccaaccc taagcacccc cagaaagctg actggccctg     6720

tggttcccac tccagacatg atgtcagctg tgaaatcgac gtcgctggac cataattagg     6780

cttctgttct tcaggagaca tttgttcaaa gtcatttggg caaccatatt ctgaaaacag     6840

cccagccagg gtgatggatc actttgcaaa gatcctcaat gagctatttt caagtgatga     6900

caaagtgtga agttaaccgc tcatttgaga actttctttt tcatccaaag taaattcaaa     6960

tatgattaga aatctgacct tttattactg gaattctctt gactaaaagt aaaattgaat     7020

tttaattcct aaatctccat gtgtatacag tactgtggga acatcacaga ttttggctcc     7080

atgccctaaa gagaaattgg ctttcagatt atttggatta aaaacaaaga ctttcttaag     7140

agatgtaaaa ttttcatgat gttttctttt ttgctaaaac taaagaatta ttcttttaca     7200

tttcagtgtt cctggaccac gagaacgcca acaagatcct gaacagaccc aagagataca     7260

acagcggcaa gctggaagag ttcgtgcagg gcaacctgga acgcgagtgc atggaagaga     7320

agtgcagctt cgaagaggcc agagaggtgt tcgagaacac cgagagaacc accgagttct     7380

ggaagcagta cgtggacggc gaccagtgcg agagcaaccc ttgtctgaac ggcggcagct     7440

gcaaggacga catcaacagc tacgagtgct ggtgcccctt cggcttcgag ggcaagaact     7500

gcgagctgga cgtgacctgc aacatcaaga acggcagatg cgagcagttc tgcaagaaca     7560

gcgccgacaa caaggtcgtg tgctcctgca ccgagggcta cagactggcc gagaaccaga     7620

agtcctgcga gcccgctgtg cctttcccat gcggaagagt gtccgtgtcc cagaccagca     7680

agctgaccag agccgagaca gtgttccccg acgtggacta cgtgaacagc accgaggccg     7740

agacaatcct ggacaacatc acccagagca cccagtcctt caacgacttc accagagtcg     7800

tgggcggcga ggatgctaag cctggccagt tcccgtggca ggtggtgctg aacggaaagg     7860

tggacgcctt ctgcggcggc tccatcgtga acgagaagtg gatcgtgaca gccgcccact     7920

gcgtggaaac cggcgtgaag atcacagtgg tggccggcga gcacaacatc gaggaaaccg     7980

agcacacaga gcagaaaaga aacgtgatca ggatcatccc ccaccacaac tacaacgccg     8040

ccatcaacaa gtacaaccac gatatcgccc tgctggaact ggacgagccc ctggtgctga     8100

atagctacgt gacccccatc tgtatcgccg acaaagagta caccaacatc tttctgaagt     8160

tcggcagcgg ctacgtgtcc ggctggggca gagtgtttca caagggcaga tccgctctgg     8220

tgctgcagta cctgagagtg cctctggtgg acagagccac ctgtctgaga agcaccaagt     8280

tcaccatcta caacaacatg ttctgcgctg gcttccacga gggcggcaga gactcttgtc     8340

agggcgattc tggcggccct cacgtgacag aggtggaagg caccagcttt ctgaccggca     8400

tcatcagctg gggcgaggaa tgcgccatga aggggaagta cggcatctac accaaggtgt     8460

ccagatacgt gaactggatc aaagaaaaga ccaagctgac ataatgaaag atggatttcc     8520

aaggttaatt cattggaatt gaaaattaac agcccccccc ccccccccct gcagatctcg     8580

agccgaattc ctgcagcccg ggggatcagc ctcgactgtg ccttctagtt gccagccatc     8640

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     8700

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     8760

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     8820

ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct cgagatccac     8880

tagactagtg tacacgcgtg atatcagatc tgttacgtaa ggaaccccta gtgatggagt     8940

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc     9000

ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aactttttgc aaaagcctag     9060

gcctccaaaa aagcctcctc actacttctg gaatagctca gaggccgagg cggcctcggc     9120

ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga gaatgggcgg aactgggcgg     9180

agttaggggc gggatgggcg gagttagggg cgggactatg gttgctgact aattgagatg     9240

catgctttgc atacttctgc ctgctgggga gcctggggac tttccacacc tggttgctga     9300

ctaattgaga tgcatgcttt gcatacttct gcctgctggg gagcctgggg actttccaca     9360

ccctaactga cacacattcc acagctgcat taatgaatcg gccaacgcgc ggggagaggc     9420

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     9480

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     9540

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     9600

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     9660

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     9720

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     9780

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     9840

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     9900

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     9960

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca    10020

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc    10080

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa    10140

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa    10200

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac    10260

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta    10320

aattaaaaat ga                                                        10332


<210>  5
<211>  10368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV6

<400>  5
gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg       60

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg      120

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat      180

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc      240

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt      300

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc      360

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga      420

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc      480

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa      540

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta      600

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg      660

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg      720

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat      780

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt      840

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa      900

aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct      960

ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag     1020

acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc ttaactatgc     1080

ggcatcagag cagattgtac tgagagtgca ccattcgacg ctctccctta tgcgactcct     1140

gcattaggaa gcagcccagt agtaggttga ggccgttgag caccgccgcc gcaaggaatg     1200

gtgcatgcaa ggagatggcg cccaacagtc ccccggccac ggggcctgcc accataccca     1260

cgccgaaaca agcgctcatg agcccgaagt ggcgagcccg atcttcccca tcggtgatgt     1320

cggcgatata ggcgccagca accgcacctg tggcgccggt gggtcaccaa gcaggaagtc     1380

aaagactttt tccggtgggc aaaggatcac gtggttgagg tggagcatga attctacgtc     1440

aaaaagggtg gagccaagaa aagacccgcc cccagtgacg cagatataag tgagcccaaa     1500

cgggtgcgcg agtcagttgc gcagccatcg acgtcagacg cggaagcttc gatcaactac     1560

gcagacaggt accaaaacaa atgttctcgt cacgtgggca tgaatctgat gctgtttccc     1620

tgcagacaat gcgagagaat gaatcagaat tcaaatatct gcttcactca cggacagaaa     1680

gactgtttag agtgctttcc cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg     1740

tatcagaaac tgtgctacat tcatcatatc atgggaaagg tgccagacgc ttgcactgcc     1800

tgcgatctgg tcaatgtgga tttggatgac tgcatctttg aacaataaat gatttaaatc     1860

aggtatggct gccgatggtt atcttccaga ttggctcgag gacaacctct ctgagggcat     1920

tcgcgagtgg tgggacttga aacctggagc cccgaaaccc aaagccaacc agcaaaagca     1980

ggacgacggc cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact     2040

cgacaagggg gagcccgtca acgcggcgga tgcagcggcc ctcgagcacg acaaggccta     2100

cgaccagcag ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga     2160

gtttcaggag cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt     2220

ccaggccaag aagagggttc tcgaaccttt tggtctggtt gaggaaggtg ctaagacggc     2280

tcctggaaag aaacgtccgg tagagcagtc gccacaagag ccagactcct cctcgggcat     2340

tggcaagaca ggccagcagc ccgctaaaaa gagactcaat tttggtcaga ctggcgactc     2400

agagtcagtc cccgacccac aacctctcgg agaacctcca gcaacccccg ctgctgtggg     2460

acctactaca atggcttcag gcggtggcgc accaatggca gacaataacg aaggcgccga     2520

cggagtgggt aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt     2580

catcaccacc agcacccgaa catgggcctt gcccacctat aacaaccacc tctacaagca     2640

aatctccagt gcttcaacgg gggccagcaa cgacaaccac tacttcggct acagcacccc     2700

ctgggggtat tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg     2760

actcatcaac aacaattggg gattccggcc caagagactc aacttcaagc tcttcaacat     2820

ccaagtcaag gaggtcacga cgaatgatgg cgtcacgacc atcgctaata accttaccag     2880

cacggttcaa gtcttctcgg actcggagta ccagttgccg tacgtcctcg gctctgcgca     2940

ccagggctgc ctccctccgt tcccggcgga cgtgttcatg attccgcagt acggctacct     3000

aacgctcaac aatggcagcc aggcagtggg acggtcatcc ttttactgcc tggaatattt     3060

cccatcgcag atgctgagaa cgggcaataa ctttaccttc agctacacct tcgaggacgt     3120

gcctttccac agcagctacg cgcacagcca gagcctggac cggctgatga atcctctcat     3180

cgaccagtac ctgtattacc tgaacagaac tcagaatcag tccggaagtg cccaaaacaa     3240

ggacttgctg tttagccggg ggtctccagc tggcatgtct gttcagccca aaaactggct     3300

acctggaccc tgttaccggc agcagcgcgt ttctaaaaca aaaacagaca acaacaacag     3360

caactttacc tggactggtg cttcaaaata taaccttaat gggcgtgaat ctataatcaa     3420

ccctggcact gctatggcct cacacaaaga cgacgaagac aagttctttc ccatgagcgg     3480

tgtcatgatt tttggaaagg agagcgccgg agcttcaaac actgcattgg acaatgtcat     3540

gatcacagac gaagaggaaa tcaaagccac taaccccgtg gccaccgaaa gatttgggac     3600

tgtggcagtc aatctccaga gcagcagcac agaccctgcg accggagatg tgcatgttat     3660

gggagcctta cctggaatgg tgtggcaaga cagagacgta tacctgcagg gtcctatttg     3720

ggccaaaatt cctcacacgg atggacactt tcacccgtct cctctcatgg gcggctttgg     3780

acttaagcac ccgcctcctc agatcctcat caaaaacacg cctgttcctg cgaatcctcc     3840

ggcagagttt tcggctacaa agtttgcttc attcatcacc cagtattcca caggacaagt     3900

gagcgtggag attgaatggg agctgcagaa agaaaacagc aaacgctgga atcccgaagt     3960

gcagtataca tctaactatg caaaatctgc caacgttgat ttcactgtgg acaacaatgg     4020

actttatact gagcctcgcc ccattggcac ccgttacctc acccgtcccc tgtaattgct     4080

tgttaatcaa taaaccgttt aattcgtttc agttgaactt tggtctctgc gtatttcttt     4140

cttatctagt ttccatatgc atgtagataa gtagcatggc gggttaatca ttaactaacc     4200

ggtacctcta gaactatagc tagcgatgac cctgctgatt ggttcgctga ccatttccgg     4260

gtgcgggacg gcgttaccag aaactcagaa ggttcgtcca accaaaccga ctctgacggc     4320

agtttacgag agagatgata gggtctgctt cagtaagcca gatgctacac aattaggctt     4380

gtacatattg tcgttagaac gcggctacaa ttaatacata accttatgta tcatacacat     4440

acgatttagg tgacactata gaatacacgg aattaattct tggccactcc ctctctgcgc     4500

gctcgctcgc tcactgaggc cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc     4560

ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg ccaactccat cactaggggt     4620

tccttacgta ggacgtcccc tgcaggcagg gaggggtgga gtcgtgacgt aaagatctga     4680

tatcatcgat cgcgatgcat taattaagcg gccgaggctc agaggcacac aggagtttct     4740

gggctcaccc tgcccccttc caacccctca gttcccatcc tccagcagct gtttgtgtgc     4800

tgcctctgaa gtccacactg aacaaacttc agcctactca tgtccctaaa atgggcaaac     4860

attgcaagca gcaaacagca aacacacagc cctccctgcc tgctgacctt ggagctgggg     4920

cagaggtcag agacctctct gggcccatgc cacctccaac atccactcga ccccttggaa     4980

tttcggtgga gaggagcaga ggttgtcctg gcgtggttta ggtagtgtga gaggggtacc     5040

cggggatctt gctaccagtg gaacagccac taaggattct gcagtgagag cagagggcca     5100

gctaagtggt actctcccag agactgtctg actcacgcca ccccctccac cttggacaca     5160

ggacgctgtg gtttctgagc caggtacaat gactcctttc ggtaagtgca gtggaagctg     5220

tacactgccc aggcaaagcg tccgggcagc gtaggcgggc gactcagatc ccagccagtg     5280

gacttagccc ctgtttgctc ctccgataac tggggtgacc ttggttaata ttcaccagca     5340

gcctcccccg ttgcccctct ggatccactg cttaaatacg gacgaggaca gggccctgtc     5400

tcctcagctt caggcaccac cactgacctg ggacagtgaa tgatccccct gatctgcggc     5460

ctcgacggta tcgataagct tgatatcgaa ttctagtcgt cgaccacttt cacaatctgc     5520

tagcaaaggt tgccaccatg cagcgcgtga acatgattat ggccgagagc cctggcctga     5580

tcaccatctg cctgctgggc tacctgctga gcgccgagtg tacaggtttg tttccttttt     5640

taaaatacat tgagtatgct tgccttttag atatagaaat atctgatgct gtcttcttca     5700

ctaaattttg attacatgat ttgacagcaa tattgaagag tctaacagcc agcacgcagg     5760

ttggtaagta ctggttcttt gttagctagg ttttcttctt cttcattttt aaaactaaat     5820

agatcgacaa tgcttatgat gcatttatgt ttaataaaca ctgttcagtt catgatttgg     5880

tcatgtaatt cctgttagaa aacattcatc tccttggttt aaaaaaatta aaagtgggaa     5940

aacaaagaaa tagcagaata tagtgaaaaa aaataaccac attatttttg tttggactta     6000

ccactttgaa atcaaaatgg gaaacaaaag cacaaacaat ggccttattt acacaaaaag     6060

tctgatttta agatatatga catttcaagg tttcagaagt atgtaatgag gtgtgtctct     6120

aattttttaa attatatatc ttcaatttaa agttttagtt aaaacataaa gattaacctt     6180

tcattagcaa gctgttagtt atcaccaaag cttttcatgg attaggaaaa aatcattttg     6240

tctctatgtc aaacatcttg gagttgatat ttggggaaac acaatactca gttgagttcc     6300

ctaggggaga aaagcaagct taagaattga cataaagagt aggaagttag ctaatgcaac     6360

atatatcact ttgttttttc acaactacag tgactttatg tatttcccag aggaaggcat     6420

acagggaaga aattatccca tttggacaaa cagcatgttc tcacaggaag catttatcac     6480

acttacttgt caactttcta gaatcaaatc tagtagctga cagtaccagg atcaggggtg     6540

ccaaccctaa gcacccccag aaagctgact ggccctgtgg ttcccactcc agacatgatg     6600

tcagctgtga aatcgacgtc gctggaccat aattaggctt ctgttcttca ggagacattt     6660

gttcaaagtc atttgggcaa ccatattctg aaaacagccc agccagggtg atggatcact     6720

ttgcaaagat cctcaatgag ctattttcaa gtgatgacaa agtgtgaagt taaccgctca     6780

tttgagaact ttctttttca tccaaagtaa attcaaatat gattagaaat ctgacctttt     6840

attactggaa ttctcttgac taaaagtaaa attgaatttt aattcctaaa tctccatgtg     6900

tatacagtac tgtgggaaca tcacagattt tggctccatg ccctaaagag aaattggctt     6960

tcagattatt tggattaaaa acaaagactt tcttaagaga tgtaaaattt tcatgatgtt     7020

ttcttttttg ctaaaactaa agaattattc ttttacattt cagtgttcct ggaccacgag     7080

aacgccaaca agatcctgaa cagacccaag agatacaaca gcggcaagct ggaagagttc     7140

gtgcagggca acctggaacg cgagtgcatg gaagagaagt gcagcttcga agaggccaga     7200

gaggtgttcg agaacaccga gagaaccacc gagttctgga agcagtacgt ggacggcgac     7260

cagtgcgaga gcaacccttg tctgaacggc ggcagctgca aggacgacat caacagctac     7320

gagtgctggt gccccttcgg cttcgagggc aagaactgcg agctggacgt gacctgcaac     7380

atcaagaacg gcagatgcga gcagttctgc aagaacagcg ccgacaacaa ggtcgtgtgc     7440

tcctgcaccg agggctacag actggccgag aaccagaagt cctgcgagcc cgctgtgcct     7500

ttcccatgcg gaagagtgtc cgtgtcccag accagcaagc tgaccagagc cgagacagtg     7560

ttccccgacg tggactacgt gaacagcacc gaggccgaga caatcctgga caacatcacc     7620

cagagcaccc agtccttcaa cgacttcacc agagtcgtgg gcggcgagga tgctaagcct     7680

ggccagttcc cgtggcaggt ggtgctgaac ggaaaggtgg acgccttctg cggcggctcc     7740

atcgtgaacg agaagtggat cgtgacagcc gcccactgcg tggaaaccgg cgtgaagatc     7800

acagtggtgg ccggcgagca caacatcgag gaaaccgagc acacagagca gaaaagaaac     7860

gtgatcagga tcatccccca ccacaactac aacgccgcca tcaacaagta caaccacgat     7920

atcgccctgc tggaactgga cgagcccctg gtgctgaata gctacgtgac ccccatctgt     7980

atcgccgaca aagagtacac caacatcttt ctgaagttcg gcagcggcta cgtgtccggc     8040

tggggcagag tgtttcacaa gggcagatcc gctctggtgc tgcagtacct gagagtgcct     8100

ctggtggaca gagccacctg tctgagaagc accaagttca ccatctacaa caacatgttc     8160

tgcgctggct tccacgaggg cggcagagac tcttgtcagg gcgattctgg cggccctcac     8220

gtgacagagg tggaaggcac cagctttctg accggcatca tcagctgggg cgaggaatgc     8280

gccatgaagg ggaagtacgg catctacacc aaggtgtcca gatacgtgaa ctggatcaaa     8340

gaaaagacca agctgacata atgaaagatg gatttccaag gttaattcat tggaattgaa     8400

aattaacagc cccccccccc cccccctgca gatctcgagc cgaattcctg cagcccgggg     8460

gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     8520

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     8580

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     8640

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt     8700

ctgaggcgga aagaaccagc tggggctcga gatccactag actagtgtac acgcgtgata     8760

tcagatctgt tacgtaagga acccctagtg atggagttgg ccactccctc tctgcgcgct     8820

cgctcgctca ctgaggccgc ccgggcaaag cccgggcggc ctcagtgagc gagcgagcgc     8880

gcagagaggg agtggccaac tttttgcaaa agcctaggcc tccaaaaaag cctcctcact     8940

acttctggaa tagctcagag gccgaggcgg cctcggcctc tgcataaata aaaaaaatta     9000

gtcagccatg gggcggagaa tgggcggaac tgggcggagt taggggcggg atgggcggag     9060

ttaggggcgg gactatggtt gctgactaat tgagatgcat gctttgcata cttctgcctg     9120

ctggggagcc tggggacttt ccacacctgg ttgctgacta attgagatgc atgctttgca     9180

tacttctgcc tgctggggag cctggggact ttccacaccc taactgacac acattccaca     9240

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     9300

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     9360

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     9420

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     9480

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     9540

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     9600

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     9660

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     9720

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     9780

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     9840

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     9900

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt     9960

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    10020

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    10080

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    10140

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    10200

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    10260

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    10320

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaat                 10368


<210>  6
<211>  10374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV8

<400>  6
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagacgc ttgcactgcc tgcgatctgg tcaatgtgga     1980

tttggatgac tgcatctttg aacaataaat gatttaaatc aggtatggct gccgatggtt     2040

atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg tgggcgctga     2100

aacctggagc cccgaagccc aaagccaacc agcaaaagca ggacgacggc cggggtctgg     2160

tgcttcctgg ctacaagtac ctcggaccct tcaacggact cgacaagggg gagcccgtca     2220

acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag ctgcaggcgg     2280

gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag cgtctgcaag     2340

aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag aagcgggttc     2400

tcgaacctct cggtctggtt gaggaaggcg ctaagacggc tcctggaaag aagagaccgg     2460

tagagccatc accccagcgt tctccagact cctctacggg catcggcaag aaaggccaac     2520

agcccgccag aaaaagactc aattttggtc agactggcga ctcagagtca gttccagacc     2580

ctcaacctct cggagaacct ccagcagcgc cctctggtgt gggacctaat acaatggctg     2640

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtagttcct     2700

cgggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2760

gaacctgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc aacgggacat     2820

cgggaggagc caccaacgac aacacctact tcggctacag caccccctgg gggtattttg     2880

actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc atcaacaaca     2940

actggggatt ccggcccaag agactcagct tcaagctctt caacatccag gtcaaggagg     3000

tcacgcagaa tgaaggcacc aagaccatcg ccaataacct caccagcacc atccaggtgt     3060

ttacggactc ggagtaccag ctgccgtacg ttctcggctc tgcccaccag ggctgcctgc     3120

ctccgttccc ggcggacgtg ttcatgattc cccagtacgg ctacctaaca ctcaacaacg     3180

gtagtcaggc cgtgggacgc tcctccttct actgcctgga atactttcct tcgcagatgc     3240

tgagaaccgg caacaacttc cagtttactt acaccttcga ggacgtgcct ttccacagca     3300

gctacgccca cagccagagc ttggaccggc tgatgaatcc tctgattgac cagtacctgt     3360

actacttgtc tcggactcaa acaacaggag gcacggcaaa tacgcagact ctgggcttca     3420

gccaaggtgg gcctaataca atggccaatc aggcaaagaa ctggctgcca ggaccctgtt     3480

accgccaaca acgcgtctca acgacaaccg ggcaaaacaa caatagcaac tttgcctgga     3540

ctgctgggac caaataccat ctgaatggaa gaaattcatt ggctaatcct ggcatcgcta     3600

tggcaacaca caaagacgac gaggagcgtt tttttcccag taacgggatc ctgatttttg     3660

gcaaacaaaa tgctgccaga gacaatgcgg attacagcga tgtcatgctc accagcgagg     3720

aagaaatcaa aaccactaac cctgtggcta cagaggaata cggtatcgtg gcagataact     3780

tgcagcagca aaacacggct cctcaaattg gaactgtcaa cagccagggg gccttacccg     3840

gtatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc aagattcctc     3900

acacggacgg caacttccac ccgtctccgc tgatgggcgg ctttggcctg aaacatcctc     3960

cgcctcagat cctgatcaag aacacgcctg tacctgcgga tcctccgacc accttcaacc     4020

agtcaaagct gaactctttc atcacgcaat acagcaccgg acaggtcagc gtggaaattg     4080

aatgggagct gcagaaggaa aacagcaagc gctggaaccc cgagatccag tacacctcca     4140

actactacaa atctacaagt gtggactttg ctgttaatac agaaggcgtg tactctgaac     4200

cccgccccat tggcacccgt tacctcaccc gtaatctgta attgcttgtt aatcaataaa     4260

ccgtttaatt cgtttcagtt gaactttggt ctctgcgtat ttctttctta tctagtttcc     4320

atatgcatgt agataagtag catggcgggt taatcattaa ctaaccggta cctctagaac     4380

tatagctagc gatgaccctg ctgattggtt cgctgaccat ttccgggtgc gggacggcgt     4440

taccagaaac tcagaaggtt cgtccaacca aaccgactct gacggcagtt tacgagagag     4500

atgatagggt ctgcttcagt aagccagatg ctacacaatt aggcttgtac atattgtcgt     4560

tagaacgcgg ctacaattaa tacataacct tatgtatcat acacatacga tttaggtgac     4620

actatagaat acacggaatt aattcttggc cactccctct ctgcgcgctc gctcgctcac     4680

tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag     4740

cgagcgagcg cgcagagagg gagtggccaa ctccatcact aggggttcct tacgtaggac     4800

gtcccctgca ggcagggagg ggtggagtcg tgacgtaaag atctgatatc atcgatcgcg     4860

atgcattaat taagcggccg aggctcagag gcacacagga gtttctgggc tcaccctgcc     4920

cccttccaac ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc     4980

acactgaaca aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa     5040

acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac     5100

ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg     5160

agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg ggtacccggg gatcttgcta     5220

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc     5280

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt     5340

ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc     5400

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt     5460

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc     5520

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg     5580

caccaccact gacctgggac agtgaatgat ccccctgatc tgcggcctcg acggtatcga     5640

taagcttgat atcgaattct agtcgtcgac cactttcaca atctgctagc aaaggttgcc     5700

accatgcagc gcgtgaacat gattatggcc gagagccctg gcctgatcac catctgcctg     5760

ctgggctacc tgctgagcgc cgagtgtaca ggtttgtttc cttttttaaa atacattgag     5820

tatgcttgcc ttttagatat agaaatatct gatgctgtct tcttcactaa attttgatta     5880

catgatttga cagcaatatt gaagagtcta acagccagca cgcaggttgg taagtactgg     5940

ttctttgtta gctaggtttt cttcttcttc atttttaaaa ctaaatagat cgacaatgct     6000

tatgatgcat ttatgtttaa taaacactgt tcagttcatg atttggtcat gtaattcctg     6060

ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag tgggaaaaca aagaaatagc     6120

agaatatagt gaaaaaaaat aaccacatta tttttgtttg gacttaccac tttgaaatca     6180

aaatgggaaa caaaagcaca aacaatggcc ttatttacac aaaaagtctg attttaagat     6240

atatgacatt tcaaggtttc agaagtatgt aatgaggtgt gtctctaatt ttttaaatta     6300

tatatcttca atttaaagtt ttagttaaaa cataaagatt aacctttcat tagcaagctg     6360

ttagttatca ccaaagcttt tcatggatta ggaaaaaatc attttgtctc tatgtcaaac     6420

atcttggagt tgatatttgg ggaaacacaa tactcagttg agttccctag gggagaaaag     6480

caagcttaag aattgacata aagagtagga agttagctaa tgcaacatat atcactttgt     6540

tttttcacaa ctacagtgac tttatgtatt tcccagagga aggcatacag ggaagaaatt     6600

atcccatttg gacaaacagc atgttctcac aggaagcatt tatcacactt acttgtcaac     6660

tttctagaat caaatctagt agctgacagt accaggatca ggggtgccaa ccctaagcac     6720

ccccagaaag ctgactggcc ctgtggttcc cactccagac atgatgtcag ctgtgaaatc     6780

gacgtcgctg gaccataatt aggcttctgt tcttcaggag acatttgttc aaagtcattt     6840

gggcaaccat attctgaaaa cagcccagcc agggtgatgg atcactttgc aaagatcctc     6900

aatgagctat tttcaagtga tgacaaagtg tgaagttaac cgctcatttg agaactttct     6960

ttttcatcca aagtaaattc aaatatgatt agaaatctga ccttttatta ctggaattct     7020

cttgactaaa agtaaaattg aattttaatt cctaaatctc catgtgtata cagtactgtg     7080

ggaacatcac agattttggc tccatgccct aaagagaaat tggctttcag attatttgga     7140

ttaaaaacaa agactttctt aagagatgta aaattttcat gatgttttct tttttgctaa     7200

aactaaagaa ttattctttt acatttcagt gttcctggac cacgagaacg ccaacaagat     7260

cctgaacaga cccaagagat acaacagcgg caagctggaa gagttcgtgc agggcaacct     7320

ggaacgcgag tgcatggaag agaagtgcag cttcgaagag gccagagagg tgttcgagaa     7380

caccgagaga accaccgagt tctggaagca gtacgtggac ggcgaccagt gcgagagcaa     7440

cccttgtctg aacggcggca gctgcaagga cgacatcaac agctacgagt gctggtgccc     7500

cttcggcttc gagggcaaga actgcgagct ggacgtgacc tgcaacatca agaacggcag     7560

atgcgagcag ttctgcaaga acagcgccga caacaaggtc gtgtgctcct gcaccgaggg     7620

ctacagactg gccgagaacc agaagtcctg cgagcccgct gtgcctttcc catgcggaag     7680

agtgtccgtg tcccagacca gcaagctgac cagagccgag acagtgttcc ccgacgtgga     7740

ctacgtgaac agcaccgagg ccgagacaat cctggacaac atcacccaga gcacccagtc     7800

cttcaacgac ttcaccagag tcgtgggcgg cgaggatgct aagcctggcc agttcccgtg     7860

gcaggtggtg ctgaacggaa aggtggacgc cttctgcggc ggctccatcg tgaacgagaa     7920

gtggatcgtg acagccgccc actgcgtgga aaccggcgtg aagatcacag tggtggccgg     7980

cgagcacaac atcgaggaaa ccgagcacac agagcagaaa agaaacgtga tcaggatcat     8040

cccccaccac aactacaacg ccgccatcaa caagtacaac cacgatatcg ccctgctgga     8100

actggacgag cccctggtgc tgaatagcta cgtgaccccc atctgtatcg ccgacaaaga     8160

gtacaccaac atctttctga agttcggcag cggctacgtg tccggctggg gcagagtgtt     8220

tcacaagggc agatccgctc tggtgctgca gtacctgaga gtgcctctgg tggacagagc     8280

cacctgtctg agaagcacca agttcaccat ctacaacaac atgttctgcg ctggcttcca     8340

cgagggcggc agagactctt gtcagggcga ttctggcggc cctcacgtga cagaggtgga     8400

aggcaccagc tttctgaccg gcatcatcag ctggggcgag gaatgcgcca tgaaggggaa     8460

gtacggcatc tacaccaagg tgtccagata cgtgaactgg atcaaagaaa agaccaagct     8520

gacataatga aagatggatt tccaaggtta attcattgga attgaaaatt aacagccccc     8580

cccccccccc cctgcagatc tcgagccgaa ttcctgcagc ccgggggatc agcctcgact     8640

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     8700

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     8760

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     8820

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga     8880

accagctggg gctcgagatc cactagacta gtgtacacgc gtgatatcag atctgttacg     8940

taaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     9000

ggccgcccgg gcaaagcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     9060

gccaactttt tgcaaaagcc taggcctcca aaaaagcctc ctcactactt ctggaatagc     9120

tcagaggccg aggcggcctc ggcctctgca taaataaaaa aaattagtca gccatggggc     9180

ggagaatggg cggaactggg cggagttagg ggcgggatgg gcggagttag gggcgggact     9240

atggttgctg actaattgag atgcatgctt tgcatacttc tgcctgctgg ggagcctggg     9300

gactttccac acctggttgc tgactaattg agatgcatgc tttgcatact tctgcctgct     9360

ggggagcctg gggactttcc acaccctaac tgacacacat tccacagctg cattaatgaa     9420

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     9480

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     9540

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     9600

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     9660

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     9720

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     9780

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     9840

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     9900

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     9960

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag    10020

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta    10080

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg    10140

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc    10200

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt    10260

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa    10320

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaa          10374


<210>  7
<211>  10332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV9

<400>  7
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagtaac gcttgcactg cctgcgatct ggtcaatgtg     1980

gatttggatg actgcatctt tgaacaataa atgatttaaa tcaggtatgg ctgccgatgg     2040

ttatcttcca gattggctcg aggacaacct tagtgaagga attcgcgagt ggtgggcttt     2100

gaaacctgga gcccctcaac ccaaggcaaa tcaacaacat caagacaacg ctcgaggtct     2160

tgtgcttccg ggttacaaat accttggacc cggcaacgga ctcgacaagg gggagccggt     2220

caacgcagca gacgcggcgg ccctcgagca cgacaaggcc tacgaccagc agctcaaggc     2280

cggagacaac ccgtacctca agtacaacca cgccgacgcc gagttccagg agcggctcaa     2340

agaagatacg tcttttgggg gcaacctcgg gcgagcagtc ttccaggcca aaaagaggct     2400

tcttgaacct cttggtctgg ttgaggaagc ggctaagacg gctcctggaa agaagaggcc     2460

tgtagagcag tctcctcagg aaccggactc ctccgcgggt attggcaaat cgggtgcaca     2520

gcccgctaaa aagagactca atttcggtca gactggcgac acagagtcag tcccagaccc     2580

tcaaccaatc ggagaacctc ccgcagcccc ctcaggtgtg ggatctctta caatggcttc     2640

aggtggtggc gcaccagtgg cagacaataa cgaaggtgcc gatggagtgg gtagttcctc     2700

gggaaattgg cattgcgatt cccaatggct gggggacaga gtcatcacca ccagcacccg     2760

aacctgggcc ctgcccacct acaacaatca cctctacaag caaatctcca acagcacatc     2820

tggaggatct tcaaatgaca acgcctactt cggctacagc accccctggg ggtattttga     2880

cttcaacaga ttccactgcc acttctcacc acgtgactgg cagcgactca tcaacaacaa     2940

ctggggattc cggcctaagc gactcaactt caagctcttc aacattcagg tcaaagaggt     3000

tacggacaac aatggagtca agaccatcgc caataacctt accagcacgg tccaggtctt     3060

cacggactca gactatcagc tcccgtacgt gctcgggtcg gctcacgagg gctgcctccc     3120

gccgttccca gcggacgttt tcatgattcc tcagtacggg tatctgacgc ttaatgatgg     3180

aagccaggcc gtgggtcgtt cgtcctttta ctgcctggaa tatttcccgt cgcaaatgct     3240

aagaacgggt aacaacttcc agttcagcta cgagtttgag aacgtacctt tccatagcag     3300

ctacgctcac agccaaagcc tggaccgact aatgaatcca ctcatcgacc aatacttgta     3360

ctatctctca aagactatta acggttctgg acagaatcaa caaacgctaa aattcagtgt     3420

ggccggaccc agcaacatgg ctgtccaggg aagaaactac atacctggac ccagctaccg     3480

acaacaacgt gtctcaacca ctgtgactca aaacaacaac agcgaatttg cttggcctgg     3540

agcttcttct tgggctctca atggacgtaa tagcttgatg aatcctggac ctgctatggc     3600

cagccacaaa gaaggagagg accgtttctt tcctttgtct ggatctttaa tttttggcaa     3660

acaaggaact ggaagagaca acgtggatgc ggacaaagtc atgataacca acgaagaaga     3720

aattaaaact actaacccgg tagcaacgga gtcctatgga caagtggcca caaaccacca     3780

gagtgcccaa gcacaggcgc agaccggctg ggttcaaaac caaggaatac ttccgggtat     3840

ggtttggcag gacagagatg tgtacctgca aggacccatt tgggccaaaa ttcctcacac     3900

ggacggcaac tttcaccctt ctccgctgat gggagggttt ggaatgaagc acccgcctcc     3960

tcagatcctc atcaaaaaca cacctgtacc tgcggatcct ccaacggcct tcaacaagga     4020

caagctgaac tctttcatca cccagtattc tactggccaa gtcagcgtgg agatcgagtg     4080

ggagctgcag aaggaaaaca gcaagcgctg gaacccggag atccagtaca cttccaacta     4140

ttacaagtct aataatgttg aatttgctgt taatactggt gtatatagtg aaccccgccc     4200

cattggcacc agatacctga ctcgtaatct gtaattgcct gttaatcaat aaaccggttg     4260

attcgtttca gttgaacttt ggtctctgcg aagggcgaat tcgtttaaac ctgcaggact     4320

aaccggtacc tctagaacta tagctagcga tgaccctgct gattggttcg ctgaccattt     4380

ccgggtgcgg gacggcgtta ccagaaactc agaaggttcg tccaaccaaa ccgactctga     4440

cggcagttta cgagagagat gatagggtct gcttcagtaa gccagatgct acacaattag     4500

gcttgtacat attgtcgtta gaacgcggct acaattaata cataacctta tgtatcatac     4560

acatacgatt taggtgacac tatagaatac acggaattaa ttcttggcca ctccctctct     4620

gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg     4680

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag     4740

gggttcctta cgtaggacgt cccctgcagg cagggagggg tggagtcgtg acgtaaagat     4800

ctgatatcat cgatcgcgat gcattaatta agcggccgag gctcagaggc acacaggagt     4860

ttctgggctc accctgcccc cttccaaccc ctcagttccc atcctccagc agctgtttgt     4920

gtgctgcctc tgaagtccac actgaacaaa cttcagccta ctcatgtccc taaaatgggc     4980

aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga ccttggagct     5040

ggggcagagg tcagagacct ctctgggccc atgccacctc caacatccac tcgacccctt     5100

ggaatttcgg tggagaggag cagaggttgt cctggcgtgg tttaggtagt gtgagagggg     5160

tacccgggga tcttgctacc agtggaacag ccactaagga ttctgcagtg agagcagagg     5220

gccagctaag tggtactctc ccagagactg tctgactcac gccaccccct ccaccttgga     5280

cacaggacgc tgtggtttct gagccaggta caatgactcc tttcggtaag tgcagtggaa     5340

gctgtacact gcccaggcaa agcgtccggg cagcgtaggc gggcgactca gatcccagcc     5400

agtggactta gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc     5460

agcagcctcc cccgttgccc ctctggatcc actgcttaaa tacggacgag gacagggccc     5520

tgtctcctca gcttcaggca ccaccactga cctgggacag tgaatgatcc ccctgatctg     5580

cggcctcgac ggtatcgata agcttgatat cgaattctag tcgtcgacca ctttcacaat     5640

ctgctagcaa aggttgccac catgcagcgc gtgaacatga ttatggccga gagccctggc     5700

ctgatcacca tctgcctgct gggctacctg ctgagcgccg agtgtacagg tttgtttcct     5760

tttttaaaat acattgagta tgcttgcctt ttagatatag aaatatctga tgctgtcttc     5820

ttcactaaat tttgattaca tgatttgaca gcaatattga agagtctaac agccagcacg     5880

caggttggta agtactggtt ctttgttagc taggttttct tcttcttcat ttttaaaact     5940

aaatagatcg acaatgctta tgatgcattt atgtttaata aacactgttc agttcatgat     6000

ttggtcatgt aattcctgtt agaaaacatt catctccttg gtttaaaaaa attaaaagtg     6060

ggaaaacaaa gaaatagcag aatatagtga aaaaaaataa ccacattatt tttgtttgga     6120

cttaccactt tgaaatcaaa atgggaaaca aaagcacaaa caatggcctt atttacacaa     6180

aaagtctgat tttaagatat atgacatttc aaggtttcag aagtatgtaa tgaggtgtgt     6240

ctctaatttt ttaaattata tatcttcaat ttaaagtttt agttaaaaca taaagattaa     6300

cctttcatta gcaagctgtt agttatcacc aaagcttttc atggattagg aaaaaatcat     6360

tttgtctcta tgtcaaacat cttggagttg atatttgggg aaacacaata ctcagttgag     6420

ttccctaggg gagaaaagca agcttaagaa ttgacataaa gagtaggaag ttagctaatg     6480

caacatatat cactttgttt tttcacaact acagtgactt tatgtatttc ccagaggaag     6540

gcatacaggg aagaaattat cccatttgga caaacagcat gttctcacag gaagcattta     6600

tcacacttac ttgtcaactt tctagaatca aatctagtag ctgacagtac caggatcagg     6660

ggtgccaacc ctaagcaccc ccagaaagct gactggccct gtggttccca ctccagacat     6720

gatgtcagct gtgaaatcga cgtcgctgga ccataattag gcttctgttc ttcaggagac     6780

atttgttcaa agtcatttgg gcaaccatat tctgaaaaca gcccagccag ggtgatggat     6840

cactttgcaa agatcctcaa tgagctattt tcaagtgatg acaaagtgtg aagttaaccg     6900

ctcatttgag aactttcttt ttcatccaaa gtaaattcaa atatgattag aaatctgacc     6960

ttttattact ggaattctct tgactaaaag taaaattgaa ttttaattcc taaatctcca     7020

tgtgtataca gtactgtggg aacatcacag attttggctc catgccctaa agagaaattg     7080

gctttcagat tatttggatt aaaaacaaag actttcttaa gagatgtaaa attttcatga     7140

tgttttcttt tttgctaaaa ctaaagaatt attcttttac atttcagtgt tcctggacca     7200

cgagaacgcc aacaagatcc tgaacagacc caagagatac aacagcggca agctggaaga     7260

gttcgtgcag ggcaacctgg aacgcgagtg catggaagag aagtgcagct tcgaagaggc     7320

cagagaggtg ttcgagaaca ccgagagaac caccgagttc tggaagcagt acgtggacgg     7380

cgaccagtgc gagagcaacc cttgtctgaa cggcggcagc tgcaaggacg acatcaacag     7440

ctacgagtgc tggtgcccct tcggcttcga gggcaagaac tgcgagctgg acgtgacctg     7500

caacatcaag aacggcagat gcgagcagtt ctgcaagaac agcgccgaca acaaggtcgt     7560

gtgctcctgc accgagggct acagactggc cgagaaccag aagtcctgcg agcccgctgt     7620

gcctttccca tgcggaagag tgtccgtgtc ccagaccagc aagctgacca gagccgagac     7680

agtgttcccc gacgtggact acgtgaacag caccgaggcc gagacaatcc tggacaacat     7740

cacccagagc acccagtcct tcaacgactt caccagagtc gtgggcggcg aggatgctaa     7800

gcctggccag ttcccgtggc aggtggtgct gaacggaaag gtggacgcct tctgcggcgg     7860

ctccatcgtg aacgagaagt ggatcgtgac agccgcccac tgcgtggaaa ccggcgtgaa     7920

gatcacagtg gtggccggcg agcacaacat cgaggaaacc gagcacacag agcagaaaag     7980

aaacgtgatc aggatcatcc cccaccacaa ctacaacgcc gccatcaaca agtacaacca     8040

cgatatcgcc ctgctggaac tggacgagcc cctggtgctg aatagctacg tgacccccat     8100

ctgtatcgcc gacaaagagt acaccaacat ctttctgaag ttcggcagcg gctacgtgtc     8160

cggctggggc agagtgtttc acaagggcag atccgctctg gtgctgcagt acctgagagt     8220

gcctctggtg gacagagcca cctgtctgag aagcaccaag ttcaccatct acaacaacat     8280

gttctgcgct ggcttccacg agggcggcag agactcttgt cagggcgatt ctggcggccc     8340

tcacgtgaca gaggtggaag gcaccagctt tctgaccggc atcatcagct ggggcgagga     8400

atgcgccatg aaggggaagt acggcatcta caccaaggtg tccagatacg tgaactggat     8460

caaagaaaag accaagctga cataatgaaa gatggatttc caaggttaat tcattggaat     8520

tgaaaattaa cagccccccc cccccccccc tgcagatctc gagccgaatt cctgcagccc     8580

gggggatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     8640

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     8700

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     8760

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     8820

gcttctgagg cggaaagaac cagctggggc tcgagatcca ctagactagt gtacacgcgt     8880

gatatcagat ctgttacgta aggaacccct agtgatggag ttggccactc cctctctgcg     8940

cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cggcctcagt gagcgagcga     9000

gcgcgcagag agggagtggc caactttttg caaaagccta ggcctccaaa aaagcctcct     9060

cactacttct ggaatagctc agaggccgag gcggcctcgg cctctgcata aataaaaaaa     9120

attagtcagc catggggcgg agaatgggcg gaactgggcg gagttagggg cgggatgggc     9180

ggagttaggg gcgggactat ggttgctgac taattgagat gcatgctttg catacttctg     9240

cctgctgggg agcctgggga ctttccacac ctggttgctg actaattgag atgcatgctt     9300

tgcatacttc tgcctgctgg ggagcctggg gactttccac accctaactg acacacattc     9360

cacagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     9420

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     9480

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     9540

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     9600

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     9660

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     9720

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     9780

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     9840

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     9900

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     9960

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc    10020

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta    10080

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg    10140

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt    10200

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg    10260

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta    10320

aatcaatcta aa                                                        10332


<210>  8
<211>  10371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV-DJ

<400>  8
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagacgc ttgcactgcc tgcgatctgg tcaatgtgga     1980

tttggatgac tgcatctttg aacaataaat gatttaaatc aggtatggct gccgatggtt     2040

atcttccaga ttggctcgag gacactctct ctgaaggaat aagacagtgg tggaagctca     2100

aacctggccc accaccacca aagcccgcag agcggcataa ggacgacagc aggggtcttg     2160

tgcttcctgg gtacaagtac ctcggaccct tcaacggact cgacaaggga gagccggtca     2220

acgaggcaga cgccgcggcc ctcgagcacg acaaagccta cgaccggcag ctcgacagcg     2280

gagacaaccc gtacctcaag tacaaccacg ccgacgccga gttccaggag cggctcaaag     2340

aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaaa aagaggcttc     2400

ttgaacctct tggtctggtt gaggaagcgg ctaagacggc tcctggaaag aagaggcctg     2460

tagagcactc tcctgtggag ccagactcct cctcgggaac cggaaaggcg ggccagcagc     2520

ctgcaagaaa aagattgaat tttggtcaga ctggagacgc agactcagtc ccagaccctc     2580

aaccaatcgg agaacctccc gcagccccct caggtgtggg atctcttaca atggctgcag     2640

gcggtggcgc accaatggca gacaataacg agggcgccga cggagtgggt aattcctcgg     2700

gaaattggca ttgcgattcc acatggatgg gcgacagagt catcaccacc agcacccgaa     2760

cctgggccct gcccacctac aacaaccacc tctacaagca aatctccaac agcacatctg     2820

gaggatcttc aaatgacaac gcctacttcg gctacagcac cccctggggg tattttgact     2880

ttaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc aacaacaact     2940

ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc aaggaggtca     3000

cgcagaatga aggcaccaag accatcgcca ataacctcac cagcaccatc caggtgttta     3060

cggactcgga gtaccagctg ccgtacgttc tcggctctgc ccaccagggc tgcctgcctc     3120

cgttcccggc ggacgtgttc atgattcccc agtacggcta cctaacactc aacaacggta     3180

gtcaggccgt gggacgctcc tccttctact gcctggaata ctttccttcg cagatgctga     3240

gaaccggcaa caacttccag tttacttaca ccttcgagga cgtgcctttc cacagcagct     3300

acgcccacag ccagagcttg gaccggctga tgaatcctct gattgaccag tacctgtact     3360

acttgtctcg gactcaaaca acaggaggca cgacaaatac gcagactctg ggcttcagcc     3420

aaggtgggcc taatacaatg gccaatcagg caaagaactg gctgccagga ccctgttacc     3480

gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac tcgtggactg     3540

gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc ccggccatgg     3600

caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc atctttggga     3660

agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca gacgaagagg     3720

aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct accaacctcc     3780

agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt cttccaggca     3840

tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag attccacaca     3900

cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa caccctccgc     3960

ctcagatcct gatcaagaac acgcctgtac ctgcggatcc tccgaccacc ttcaaccagt     4020

caaagctgaa ctctttcatc acccagtatt ctactggcca agtcagcgtg gagatcgagt     4080

gggagctgca gaaggaaaac agcaagcgct ggaaccccga gatccagtac acctccaact     4140

actacaaatc tacaagtgtg gactttgctg ttaatacaga aggcgtgtac tctgaacccc     4200

gccccattgg cacccgttac ctcacccgta atctgtaatt gcttgttaat caataaaccg     4260

tttaattcgt ttcagttgaa ctttggtctc tgcgtatttc tttcttatct agtttccata     4320

tgcatgtaga taagtagcat ggcgggttaa tcattaacta accggtacct ctagaactat     4380

agctagcgat gaccctgctg attggttcgc tgaccatttc cgggtgcggg acggcgttac     4440

cagaaactca gaaggttcgt ccaaccaaac cgactctgac ggcagtttac gagagagatg     4500

atagggtctg cttcagtaag ccagatgcta cacaattagg cttgtacata ttgtcgttag     4560

aacgcggcta caattaatac ataaccttat gtatcataca catacgattt aggtgacact     4620

atagaataca cggaattaat tcttggccac tccctctctg cgcgctcgct cgctcactga     4680

ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga     4740

gcgagcgcgc agagagggag tggccaactc catcactagg ggttccttac gtaggacgtc     4800

ccctgcaggc agggaggggt ggagtcgtga cgtaaagatc tgatatcatc gatcgcgatg     4860

cattaattaa gcggccgagg ctcagaggca cacaggagtt tctgggctca ccctgccccc     4920

ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct gaagtccaca     4980

ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa gcagcaaaca     5040

gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt cagagacctc     5100

tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt ggagaggagc     5160

agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat cttgctacca     5220

gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt ggtactctcc     5280

cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct gtggtttctg     5340

agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa     5400

gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag cccctgtttg     5460

ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc ccgttgcccc     5520

tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag cttcaggcac     5580

caccactgac ctgggacagt gaatgatccc cctgatctgc ggcctcgacg gtatcgataa     5640

gcttgatatc gaattctagt cgtcgaccac tttcacaatc tgctagcaaa ggttgccacc     5700

atgcagcgcg tgaacatgat tatggccgag agccctggcc tgatcaccat ctgcctgctg     5760

ggctacctgc tgagcgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat     5820

gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat     5880

gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactggttc     5940

tttgttagct aggttttctt cttcttcatt tttaaaacta aatagatcga caatgcttat     6000

gatgcattta tgtttaataa acactgttca gttcatgatt tggtcatgta attcctgtta     6060

gaaaacattc atctccttgg tttaaaaaaa ttaaaagtgg gaaaacaaag aaatagcaga     6120

atatagtgaa aaaaaataac cacattattt ttgtttggac ttaccacttt gaaatcaaaa     6180

tgggaaacaa aagcacaaac aatggcctta tttacacaaa aagtctgatt ttaagatata     6240

tgacatttca aggtttcaga agtatgtaat gaggtgtgtc tctaattttt taaattatat     6300

atcttcaatt taaagtttta gttaaaacat aaagattaac ctttcattag caagctgtta     6360

gttatcacca aagcttttca tggattagga aaaaatcatt ttgtctctat gtcaaacatc     6420

ttggagttga tatttgggga aacacaatac tcagttgagt tccctagggg agaaaagcaa     6480

gcttaagaat tgacataaag agtaggaagt tagctaatgc aacatatatc actttgtttt     6540

ttcacaacta cagtgacttt atgtatttcc cagaggaagg catacaggga agaaattatc     6600

ccatttggac aaacagcatg ttctcacagg aagcatttat cacacttact tgtcaacttt     6660

ctagaatcaa atctagtagc tgacagtacc aggatcaggg gtgccaaccc taagcacccc     6720

cagaaagctg actggccctg tggttcccac tccagacatg atgtcagctg tgaaatcgac     6780

gtcgctggac cataattagg cttctgttct tcaggagaca tttgttcaaa gtcatttggg     6840

caaccatatt ctgaaaacag cccagccagg gtgatggatc actttgcaaa gatcctcaat     6900

gagctatttt caagtgatga caaagtgtga agttaaccgc tcatttgaga actttctttt     6960

tcatccaaag taaattcaaa tatgattaga aatctgacct tttattactg gaattctctt     7020

gactaaaagt aaaattgaat tttaattcct aaatctccat gtgtatacag tactgtggga     7080

acatcacaga ttttggctcc atgccctaaa gagaaattgg ctttcagatt atttggatta     7140

aaaacaaaga ctttcttaag agatgtaaaa ttttcatgat gttttctttt ttgctaaaac     7200

taaagaatta ttcttttaca tttcagtgtt cctggaccac gagaacgcca acaagatcct     7260

gaacagaccc aagagataca acagcggcaa gctggaagag ttcgtgcagg gcaacctgga     7320

acgcgagtgc atggaagaga agtgcagctt cgaagaggcc agagaggtgt tcgagaacac     7380

cgagagaacc accgagttct ggaagcagta cgtggacggc gaccagtgcg agagcaaccc     7440

ttgtctgaac ggcggcagct gcaaggacga catcaacagc tacgagtgct ggtgcccctt     7500

cggcttcgag ggcaagaact gcgagctgga cgtgacctgc aacatcaaga acggcagatg     7560

cgagcagttc tgcaagaaca gcgccgacaa caaggtcgtg tgctcctgca ccgagggcta     7620

cagactggcc gagaaccaga agtcctgcga gcccgctgtg cctttcccat gcggaagagt     7680

gtccgtgtcc cagaccagca agctgaccag agccgagaca gtgttccccg acgtggacta     7740

cgtgaacagc accgaggccg agacaatcct ggacaacatc acccagagca cccagtcctt     7800

caacgacttc accagagtcg tgggcggcga ggatgctaag cctggccagt tcccgtggca     7860

ggtggtgctg aacggaaagg tggacgcctt ctgcggcggc tccatcgtga acgagaagtg     7920

gatcgtgaca gccgcccact gcgtggaaac cggcgtgaag atcacagtgg tggccggcga     7980

gcacaacatc gaggaaaccg agcacacaga gcagaaaaga aacgtgatca ggatcatccc     8040

ccaccacaac tacaacgccg ccatcaacaa gtacaaccac gatatcgccc tgctggaact     8100

ggacgagccc ctggtgctga atagctacgt gacccccatc tgtatcgccg acaaagagta     8160

caccaacatc tttctgaagt tcggcagcgg ctacgtgtcc ggctggggca gagtgtttca     8220

caagggcaga tccgctctgg tgctgcagta cctgagagtg cctctggtgg acagagccac     8280

ctgtctgaga agcaccaagt tcaccatcta caacaacatg ttctgcgctg gcttccacga     8340

gggcggcaga gactcttgtc agggcgattc tggcggccct cacgtgacag aggtggaagg     8400

caccagcttt ctgaccggca tcatcagctg gggcgaggaa tgcgccatga aggggaagta     8460

cggcatctac accaaggtgt ccagatacgt gaactggatc aaagaaaaga ccaagctgac     8520

ataatgaaag atggatttcc aaggttaatt cattggaatt gaaaattaac agcccccccc     8580

ccccccccct gcagatctcg agccgaattc ctgcagcccg ggggatcagc ctcgactgtg     8640

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     8700

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     8760

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     8820

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc     8880

agctggggct cgagatccac tagactagtg tacacgcgtg atatcagatc tgttacgtaa     8940

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     9000

cgcccgggca aagcccgggc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     9060

aactttttgc aaaagcctag gcctccaaaa aagcctcctc actacttctg gaatagctca     9120

gaggccgagg cggcctcggc ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga     9180

gaatgggcgg aactgggcgg agttaggggc gggatgggcg gagttagggg cgggactatg     9240

gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga gcctggggac     9300

tttccacacc tggttgctga ctaattgaga tgcatgcttt gcatacttct gcctgctggg     9360

gagcctgggg actttccaca ccctaactga cacacattcc acagctgcat taatgaatcg     9420

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg     9480

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     9540

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     9600

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     9660

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     9720

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     9780

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     9840

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     9900

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     9960

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    10020

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    10080

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    10140

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    10200

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    10260

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    10320

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa a             10371


<210>  9
<211>  10368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV-LK03

<400>  9
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta attgcttgtt     2220

aatcaataaa ccgtttaatt cgtttcagtt gaactttggt ctctgcgtat ttctttctta     2280

tctagtttcc atatgcatgt agataagtag catggcgggt taatcattaa ctaaccggta     2340

cctctagaac tatagctagc gatgaccctg ctgattggtt cgctgaccat ttccgggtgc     2400

gggacggcgt taccagaaac tcagaaggtt cgtccaacca aaccgactct gacggcagtt     2460

tacgagagag atgatagggt ctgcttcagt aagccagatg ctacacaatt aggcttgtac     2520

atattgtcgt tagaacgcgg ctacaattaa tacataacct tatgtatcat acacatacga     2580

tttaggtgac actatagaat acacggaatt aattcttggc cactccctct ctgcgcgctc     2640

gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg     2700

cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact aggggttcct     2760

tacgtaggac gtcccctgca ggcagggagg ggtggagtcg tgacgtaaag atctgatatc     2820

atcgatcgcg atgcattaat taagcggccg aggctcagag gcacacagga gtttctgggc     2880

tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc     2940

tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg gcaaacattg     3000

caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga     3060

ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc     3120

ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg ggtacccggg     3180

gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     3240

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac     3300

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca     3360

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact     3420

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct     3480

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct     3540

cagcttcagg caccaccact gacctgggac agtgaatgat ccccctgatc tgcggcctcg     3600

acggtatcga taagcttgat atcgaattct agtcgtcgac cactttcaca atctgctagc     3660

aaaggttgcc accatgcagc gcgtgaacat gattatggcc gagagccctg gcctgatcac     3720

catctgcctg ctgggctacc tgctgagcgc cgagtgtaca ggtttgtttc cttttttaaa     3780

atacattgag tatgcttgcc ttttagatat agaaatatct gatgctgtct tcttcactaa     3840

attttgatta catgatttga cagcaatatt gaagagtcta acagccagca cgcaggttgg     3900

taagtactgg ttctttgtta gctaggtttt cttcttcttc atttttaaaa ctaaatagat     3960

cgacaatgct tatgatgcat ttatgtttaa taaacactgt tcagttcatg atttggtcat     4020

gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa aaattaaaag tgggaaaaca     4080

aagaaatagc agaatatagt gaaaaaaaat aaccacatta tttttgtttg gacttaccac     4140

tttgaaatca aaatgggaaa caaaagcaca aacaatggcc ttatttacac aaaaagtctg     4200

attttaagat atatgacatt tcaaggtttc agaagtatgt aatgaggtgt gtctctaatt     4260

ttttaaatta tatatcttca atttaaagtt ttagttaaaa cataaagatt aacctttcat     4320

tagcaagctg ttagttatca ccaaagcttt tcatggatta ggaaaaaatc attttgtctc     4380

tatgtcaaac atcttggagt tgatatttgg ggaaacacaa tactcagttg agttccctag     4440

gggagaaaag caagcttaag aattgacata aagagtagga agttagctaa tgcaacatat     4500

atcactttgt tttttcacaa ctacagtgac tttatgtatt tcccagagga aggcatacag     4560

ggaagaaatt atcccatttg gacaaacagc atgttctcac aggaagcatt tatcacactt     4620

acttgtcaac tttctagaat caaatctagt agctgacagt accaggatca ggggtgccaa     4680

ccctaagcac ccccagaaag ctgactggcc ctgtggttcc cactccagac atgatgtcag     4740

ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt tcttcaggag acatttgttc     4800

aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg atcactttgc     4860

aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac cgctcatttg     4920

agaactttct ttttcatcca aagtaaattc aaatatgatt agaaatctga ccttttatta     4980

ctggaattct cttgactaaa agtaaaattg aattttaatt cctaaatctc catgtgtata     5040

cagtactgtg ggaacatcac agattttggc tccatgccct aaagagaaat tggctttcag     5100

attatttgga ttaaaaacaa agactttctt aagagatgta aaattttcat gatgttttct     5160

tttttgctaa aactaaagaa ttattctttt acatttcagt gttcctggac cacgagaacg     5220

ccaacaagat cctgaacaga cccaagagat acaacagcgg caagctggaa gagttcgtgc     5280

agggcaacct ggaacgcgag tgcatggaag agaagtgcag cttcgaagag gccagagagg     5340

tgttcgagaa caccgagaga accaccgagt tctggaagca gtacgtggac ggcgaccagt     5400

gcgagagcaa cccttgtctg aacggcggca gctgcaagga cgacatcaac agctacgagt     5460

gctggtgccc cttcggcttc gagggcaaga actgcgagct ggacgtgacc tgcaacatca     5520

agaacggcag atgcgagcag ttctgcaaga acagcgccga caacaaggtc gtgtgctcct     5580

gcaccgaggg ctacagactg gccgagaacc agaagtcctg cgagcccgct gtgcctttcc     5640

catgcggaag agtgtccgtg tcccagacca gcaagctgac cagagccgag acagtgttcc     5700

ccgacgtgga ctacgtgaac agcaccgagg ccgagacaat cctggacaac atcacccaga     5760

gcacccagtc cttcaacgac ttcaccagag tcgtgggcgg cgaggatgct aagcctggcc     5820

agttcccgtg gcaggtggtg ctgaacggaa aggtggacgc cttctgcggc ggctccatcg     5880

tgaacgagaa gtggatcgtg acagccgccc actgcgtgga aaccggcgtg aagatcacag     5940

tggtggccgg cgagcacaac atcgaggaaa ccgagcacac agagcagaaa agaaacgtga     6000

tcaggatcat cccccaccac aactacaacg ccgccatcaa caagtacaac cacgatatcg     6060

ccctgctgga actggacgag cccctggtgc tgaatagcta cgtgaccccc atctgtatcg     6120

ccgacaaaga gtacaccaac atctttctga agttcggcag cggctacgtg tccggctggg     6180

gcagagtgtt tcacaagggc agatccgctc tggtgctgca gtacctgaga gtgcctctgg     6240

tggacagagc cacctgtctg agaagcacca agttcaccat ctacaacaac atgttctgcg     6300

ctggcttcca cgagggcggc agagactctt gtcagggcga ttctggcggc cctcacgtga     6360

cagaggtgga aggcaccagc tttctgaccg gcatcatcag ctggggcgag gaatgcgcca     6420

tgaaggggaa gtacggcatc tacaccaagg tgtccagata cgtgaactgg atcaaagaaa     6480

agaccaagct gacataatga aagatggatt tccaaggtta attcattgga attgaaaatt     6540

aacagccccc cccccccccc cctgcagatc tcgagccgaa ttcctgcagc ccgggggatc     6600

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     6660

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     6720

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     6780

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     6840

ggcggaaaga accagctggg gctcgagatc cactagacta gtgtacacgc gtgatatcag     6900

atctgttacg taaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     6960

cgctcactga ggccgcccgg gcaaagcccg ggcggcctca gtgagcgagc gagcgcgcag     7020

agagggagtg gccaactttt tgcaaaagcc taggcctcca aaaaagcctc ctcactactt     7080

ctggaatagc tcagaggccg aggcggcctc ggcctctgca taaataaaaa aaattagtca     7140

gccatggggc ggagaatggg cggaactggg cggagttagg ggcgggatgg gcggagttag     7200

gggcgggact atggttgctg actaattgag atgcatgctt tgcatacttc tgcctgctgg     7260

ggagcctggg gactttccac acctggttgc tgactaattg agatgcatgc tttgcatact     7320

tctgcctgct ggggagcctg gggactttcc acaccctaac tgacacacat tccacagctg     7380

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     7440

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     7500

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     7560

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     7620

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     7680

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     7740

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     7800

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     7860

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     7920

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     7980

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     8040

ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     8100

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     8160

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     8220

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     8280

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     8340

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     8400

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     8460

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     8520

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     8580

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     8640

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     8700

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     8760

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     8820

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     8880

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     8940

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     9000

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     9060

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     9120

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     9180

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     9240

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     9300

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     9360

cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg     9420

aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca catgcagctc     9480

ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc ccgtcagggc     9540

gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact atgcggcatc agagcagatt     9600

gtactgagag tgcaccattc gacgctctcc cttatgcgac tcctgcatta ggaagcagcc     9660

cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg aatggtgcat gcaaggagat     9720

ggcgcccaac agtcccccgg ccacggggcc tgccaccata cccacgccga aacaagcgct     9780

catgagcccg aagtggcgag cccgatcttc cccatcggtg atgtcggcga tataggcgcc     9840

agcaaccgca cctgtggcgc cggtgggtca ccaagcagga agtcaaagac tttttccggt     9900

gggcaaagga tcacgtggtt gaggtggagc atgaattcta cgtcaaaaag ggtggagcca     9960

agaaaagacc cgcccccagt gacgcagata taagtgagcc caaacgggtg cgcgagtcag    10020

ttgcgcagcc atcgacgtca gacgcggaag cttcgatcaa ctacgcagac aggtaccaaa    10080

acaaatgttc tcgtcacgtg ggcatgaatc tgatgctgtt tccctgcaga caatgcgaga    10140

gaatgaatca gaattcaaat atctgcttca ctcacggaca gaaagactgt ttagagtgct    10200

ttcccgtgtc agaatctcaa cccgtttctg tcgtcaaaaa ggcgtatcag aaactgtgct    10260

acattcatca tatcatggga aaggtgccag acgcttgcac tgcctgcgat ctggtcaatg    10320

tggatttgga tgactgcatc tttgaacaat aaatgattta aatcaggt                 10368


<210>  10
<211>  10365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Payload/Cap Plasmid Factor IX / AAV-sL65

<400>  10
cccctgtaat tgcttgttaa tcaataaacc gtttaattcg tttcagttga actttggtct       60

ctgcgtattt ctttcttatc tagtttccat atgcatgtag ataagtagca tggcgggtta      120

atcattaact aaccggtacc tctagaacta tagctagcga tgaccctgct gattggttcg      180

ctgaccattt ccgggtgcgg gacggcgtta ccagaaactc agaaggttcg tccaaccaaa      240

ccgactctga cggcagttta cgagagagat gatagggtct gcttcagtaa gccagatgct      300

acacaattag gcttgtacat attgtcgtta gaacgcggct acaattaata cataacctta      360

tgtatcatac acatacgatt taggtgacac tatagaatac acggaattaa ttcttggcca      420

ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg      480

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact      540

ccatcactag gggttcctta cgtaggacgt cccctgcagg cagggagggg tggagtcgtg      600

acgtaaagat ctgatatcat cgatcgcgat gcgagagtta agcggccgag gctcagaggc      660

acacaggagt ttctgggctc accctgcccc cttccaaccc ctcagttccc atcctccagc      720

agctgtttgt gtgctgcctc tgaagtccac actgaacaaa cttcagccta ctcatgtccc      780

taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga      840

ccttggagct ggggcagagg tcagagacct ctctgggccc atgccacctc caacatccac      900

tcgacccctt ggaatttcgg tggagaggag cagaggttgt cctggcgtgg tttaggtagt      960

gtgagagggg tacccgggga tcttgctacc agtggaacag ccactaagga ttctgcagtg     1020

agagcagagg gccagctaag tggtactctc ccagagactg tctgactcac gccaccccct     1080

ccaccttgga cacaggacgc tgtggtttct gagccaggta caatgactcc tttcggtaag     1140

tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc gggcgactca     1200

gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt gaccttggtt     1260

aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa tacggacgag     1320

gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag tgaatgatcc     1380

ccctgatctg cggcctcgac ggtatcgata agcttgatat cgaattctag tcgtcgacca     1440

ctttcacaat ctgctagcaa aggttgccac catgcagcgc gtgaacatga ttatggccga     1500

gagccctggc ctgatcacca tctgcctgct gggctacctg ctgagcgccg agtgtacagg     1560

tttgtttcct tttttaaaat acattgagta tgcttgcctt ttagatatag aaatatctga     1620

tgctgtcttc ttcactaaat tttgattaca tgatttgaca gcaatattga agagtctaac     1680

agccagcacg caggttggta agtactggtt ctttgttagc taggttttct tcttcttcat     1740

ttttaaaact aaatagatcg acaatgctta tgatgcattt atgtttaata aacactgttc     1800

agttcatgat ttggtcatgt aattcctgtt agaaaacatt catctccttg gtttaaaaaa     1860

attaaaagtg ggaaaacaaa gaaatagcag aatatagtga aaaaaaataa ccacattatt     1920

tttgtttgga cttaccactt tgaaatcaaa atgggaaaca aaagcacaaa caatggcctt     1980

atttacacaa aaagtctgat tttaagatat atgacatttc aaggtttcag aagtatgtaa     2040

tgaggtgtgt ctctaatttt ttaaattata tatcttcaat ttaaagtttt agttaaaaca     2100

taaagattaa cctttcatta gcaagctgtt agttatcacc aaagcttttc atggattagg     2160

aaaaaatcat tttgtctcta tgtcaaacat cttggagttg atatttgggg aaacacaata     2220

ctcagttgag ttccctaggg gagaaaagca agcttaagaa ttgacataaa gagtaggaag     2280

ttagctaatg caacatatat cactttgttt tttcacaact acagtgactt tatgtatttc     2340

ccagaggaag gcatacaggg aagaaattat cccatttgga caaacagcat gttctcacag     2400

gaagcattta tcacacttac ttgtcaactt tctagaatca aatctagtag ctgacagtac     2460

caggatcagg ggtgccaacc ctaagcaccc ccagaaagct gactggccct gtggttccca     2520

ctccagacat gatgtcagct gtgaaatcga cgtcgctgga ccataattag gcttctgttc     2580

ttcaggagac atttgttcaa agtcatttgg gcaaccatat tctgaaaaca gcccagccag     2640

ggtgatggat cactttgcaa agatcctcaa tgagctattt tcaagtgatg acaaagtgtg     2700

aagttaaccg ctcatttgag aactttcttt ttcatccaaa gtaaattcaa atatgattag     2760

aaatctgacc ttttattact ggaattctct tgactaaaag taaaattgaa ttttaattcc     2820

taaatctcca tgtgtataca gtactgtggg aacatcacag attttggctc catgccctaa     2880

agagaaattg gctttcagat tatttggatt aaaaacaaag actttcttaa gagatgtaaa     2940

attttcatga tgttttcttt tttgctaaaa ctaaagaatt attcttttac atttcagtgt     3000

tcctggacca cgagaacgcc aacaagatcc tgaacagacc caagagatac aacagcggca     3060

agctggaaga gttcgtgcag ggcaacctgg aacgcgagtg catggaagag aagtgcagct     3120

tcgaagaggc cagagaggtg ttcgagaaca ccgagagaac caccgagttc tggaagcagt     3180

acgtggacgg cgaccagtgc gagagcaacc cttgtctgaa cggcggcagc tgcaaggacg     3240

acatcaacag ctacgagtgc tggtgcccct tcggcttcga gggcaagaac tgcgagctgg     3300

acgtgacctg caacatcaag aacggcagat gcgagcagtt ctgcaagaac agcgccgaca     3360

acaaggtcgt gtgctcctgc accgagggct acagactggc cgagaaccag aagtcctgcg     3420

agcccgctgt gcctttccca tgcggaagag tgtccgtgtc ccagaccagc aagctgacca     3480

gagccgagac agtgttcccc gacgtggact acgtgaacag caccgaggcc gagacaatcc     3540

tggacaacat cacccagagc acccagtcct tcaacgactt caccagagtc gtgggcggcg     3600

aggatgctaa gcctggccag ttcccgtggc aggtggtgct gaacggaaag gtggacgcct     3660

tctgcggcgg ctccatcgtg aacgagaagt ggatcgtgac agccgcccac tgcgtggaaa     3720

ccggcgtgaa gatcacagtg gtggccggcg agcacaacat cgaggaaacc gagcacacag     3780

agcagaaaag aaacgtgatc aggatcatcc cccaccacaa ctacaacgcc gccatcaaca     3840

agtacaacca cgatatcgcc ctgctggaac tggacgagcc cctggtgctg aatagctacg     3900

tgacccccat ctgtatcgcc gacaaagagt acaccaacat ctttctgaag ttcggcagcg     3960

gctacgtgtc cggctggggc agagtgtttc acaagggcag atccgctctg gtgctgcagt     4020

acctgagagt gcctctggtg gacagagcca cctgtctgag aagcaccaag ttcaccatct     4080

acaacaacat gttctgcgct ggcttccacg agggcggcag agactcttgt cagggcgatt     4140

ctggcggccc tcacgtgaca gaggtggaag gcaccagctt tctgaccggc atcatcagct     4200

ggggcgagga atgcgccatg aaggggaagt acggcatcta caccaaggtg tccagatacg     4260

tgaactggat caaagaaaag accaagctga cataatgaaa gatggatttc caaggttaat     4320

tcattggaat tgaaaattaa cagccccccc cccccccccc tgcagatctc gagccgaatt     4380

cctgcagccc gggggatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg     4440

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     4500

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     4560

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     4620

gggctctatg gcttctgagg cggaaagaac cagctggggc tcgagatcca ctagactagt     4680

gtacacgcgt gatatcagat ctgttacgta aggaacccct agtgatggag ttggccactc     4740

cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg cggcctcagt     4800

gagcgagcga gcgcgcagag agggagtggc caactttttg caaaagccta ggcctccaaa     4860

aaagcctcct cactacttct ggaatagctc agaggccgag gcggcctcgg cctctgcata     4920

aataaaaaaa attagtcagc catggggcgg agaatgggcg gaactgggcg gagttagggg     4980

cgggatgggc ggagttaggg gcgggactat ggttgctgac taattgagat gcatgctttg     5040

catacttctg cctgctgggg agcctgggga ctttccacac ctggttgctg actaattgag     5100

atgcatgctt tgcatacttc tgcctgctgg ggagcctggg gactttccac accctaactg     5160

acacacattc cacagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     5220

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     5280

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     5340

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     5400

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     5460

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     5520

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     5580

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag     5640

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     5700

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     5760

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     5820

aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg     5880

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     5940

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     6000

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     6060

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     6120

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     6180

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     6240

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     6300

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     6360

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     6420

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     6480

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     6540

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     6600

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     6660

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     6720

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     6780

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     6840

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     6900

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     6960

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     7020

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     7080

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     7140

tttccccgaa aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat     7200

aaaaataggc gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac     7260

ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc     7320

agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat     7380

gcggcatcag agcagattgt actgagagtg caccattcga cgctctccct tatgcgactc     7440

ctgcattagg aagcagccca gtagtaggtt gaggccgttg agcaccgccg ccgcaaggaa     7500

tggtgcatgc aaggagatgg cgcccaacag tcccccggcc acggggcctg ccaccatacc     7560

cacgccgaaa caagcgctca tgagcccgaa gtggcgagcc cgatcttccc catcggtgat     7620

gtcggcgata taggcgccag caaccgcacc tgtggcgccg gtgggtcacc aagcaggaag     7680

tcaaagactt tttccggtgg gcaaaggatc acgtggttga ggtggagcat gaattctacg     7740

tcaaaaaggg tggagccaag aaaagacccg cccccagtga cgcagatata agtgagccca     7800

aacgggtgcg cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgatcaact     7860

acgcagacag gtaccaaaac aaatgttctc gtcacgtggg catgaatctg atgctgtttc     7920

cctgcagaca atgcgagaga atgaatcaga attcaaatat ctgcttcact cacggacaga     7980

aagactgttt agagtgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcaaaaagg     8040

cgtatcagaa actgtgctac attcatcata tcatgggaaa ggtgccagac gcttgcactg     8100

cctgcgatct ggtcaatgtg gatttggatg actgcatctt tgaacaataa atgatttaaa     8160

tcaggtatgg ctgctgacgg ttatcttcca gattggctcg aggacactct ctctgaaggc     8220

attcgcgagt ggtgggcgct gaaacctgga gctccacaac ccaaggccaa ccaacagcat     8280

caggacaacg gcaggggtct tgtgcttcct gggtacaagt acctcggacc cttcaacgga     8340

ctcgacaagg gagagccggt caacgaggca gacgccgcgg ccctcgagca cgacaaggcc     8400

tacgacaagc agctcgagca gggggacaac ccgtacctca agtacaacca cgccgacgcc     8460

gagtttcagg agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc     8520

ttccaggcca agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg     8580

gctcctggaa agaagagacc ggtagagccg tcacctcagc gttcccccga ctcctccacg     8640

ggcatcggca agaaaggcca gcagcccgcc agaaagagac tcaatttcgg tcagactggc     8700

gactcagagt cagtccccga ccctcaacct ctcggagaac ctccagcagc gccctctagt     8760

gtgggatctg gtacagtggc tgcaggcggt ggcgcaccaa tggcagacaa taacgaaggt     8820

gccgacggag tgggtaatgc ctcaggaaat tggcattgcg attccacatg gctgggcgac     8880

agagtcatta ccaccagcac ccgaacctgg gccctgccca cctacaacaa ccacctctac     8940

aagcaaatct ccagccaatc aggagcttca aacgacaacc actactttgg ctacagcacc     9000

ccttgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag     9060

cgactcatta acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac     9120

atccaagtca aggaggtcac gacgaatgat ggcgtcacga ccatcgctaa taaccttacc     9180

agcacggttc aagtcttctc ggactcggag taccagttgc cgtacgtcct cggctctgcg     9240

caccagggct gcctccctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     9300

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttttactg cctggaatat     9360

ttcccatcgc agatgctgag aacgggcaat aactttgagt tcagctacag cttcgaggac     9420

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     9480

attgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     9540

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc caagaactgg     9600

ctgcctggac cttgctaccg gcagcagcga gtctccacga cactgtcgca aaacaacaac     9660

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     9720

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     9780

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     9840

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     9900

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     9960

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatttgg    10020

gccaaaattc ctcacacaga tggacacttt cacccgtctc ctcttatggg cggctttgga    10080

ctcaagaacc cgcctcctca gatcctcatc aaaaacacgc ctgttcctgc gaatcctccg    10140

gcggagtttt cagctacaaa gtttgcttca ttcatcaccc agtattccac aggacaagtg    10200

agcgtggaga ttgaatggga gctgcagaaa gaaaacagca aacgctggaa tcccgaagtg    10260

cagtatacat ctaactatgc aaaatctgcc aacgttgatt tcactgtgga caacaatgga    10320

ctttatactg agcctcgccc cattggcacc cgttacctta cccgt                    10365


<210>  11
<211>  4174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Plasmid Backbone 1 for insertion of Payload / Cap

<400>  11
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagacgc ttgcactgcc tgcgatctgg tcaatgtgga     1980

tttggatgac tgcatctttg aacaataaat gatttaaatc aggtttgctt gttaatcaat     2040

aaaccgttta attcgtttca gttgaacttt ggtctctgcg tatttctttc ttatctagtt     2100

tccatatgca tgtagataag tagcatggcg ggttaatcat taactaaccg gtacctctag     2160

aactatagct agcgatgacc ctgctgattg gttcgctgac catttccggg tgcgggacgg     2220

cgttaccaga aactcagaag gttcgtccaa ccaaaccgac tctgacggca gtttacgaga     2280

gagatgatag ggtctgcttc agtaagccag atgctacaca attaggcttg tacatattgt     2340

cgttagaacg cggctacaat taatacataa ccttatgtat catacacata cgatttaggt     2400

gacactatag aatacacgga attaattctt ggccactccc tctctgcgcg ctcgctcgct     2460

cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt     2520

gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt ccttacgtag     2580

gacgtcccct gcaggcaggg aggggtggag tcgtgacgta aagatctgat atcatcgatc     2640

gcgatgcatt aattaagcgg ccgcttctga ggcggaaaga accagctggg gctcgagatc     2700

cactagacta gtgtacacgc gtgatatcag atctgttacg taaggaaccc ctagtgatgg     2760

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg     2820

ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gccaactttt tgcaaaagcc     2880

taggcctcca aaaaagcctc ctcactactt ctggaatagc tcagaggccg aggcggcctc     2940

ggcctctgca taaataaaaa aaattagtca gccatggggc ggagaatggg cggaactggg     3000

cggagttagg ggcgggatgg gcggagttag gggcgggact atggttgctg actaattgag     3060

atgcatgctt tgcatacttc tgcctgctgg ggagcctggg gactttccac acctggttgc     3120

tgactaattg agatgcatgc tttgcatact tctgcctgct ggggagcctg gggactttcc     3180

acaccctaac tgacacacat tccacagctg cattaatgaa tcggccaacg cgcggggaga     3240

ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3300

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3360

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3420

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3480

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3540

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3600

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3660

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3720

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3780

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     3840

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     3900

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     3960

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4020

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4080

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4140

ttaaattaaa aatgaagttt taaatcaatc taaa                                 4174


<210>  12
<211>  3884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Plasmid Backbone 2 for insertion of Payload / Cap

<400>  12
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagacgc ttgcactgcc tgcgatctgg tcaatgtgga     1980

tttggatgac tgcatctttg aacaataaat gatttaaata ccggtacctc tagaactata     2040

gctagcgatg accctgctga ttggttcgct gaccatttcc gggtgcggga cggcgttacc     2100

agaaactcag aaggttcgtc caaccaaacc gactctgacg gcagtttacg agagagatga     2160

tagggtctgc ttcagtaagc cagatgctac acaattaggc ttgtacatat tgtcgttaga     2220

acgcggctac aattaataca taaccttatg tatcatacac atacgattta ggtgacacta     2280

tagaatacac ggaattaatt cttggccact ccctctctgc gcgctcgctc gctcactgag     2340

gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag     2400

cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttacg taaggaaccc     2460

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgcccgg     2520

gcaaagcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gccaactttt     2580

tgcaaaagcc taggcctcca aaaaagcctc ctcactactt ctggaatagc tcagaggccg     2640

aggcggcctc ggcctctgca taaataaaaa aaattagtca gccatggggc ggagaatggg     2700

cggaactggg cggagttagg ggcgggatgg gcggagttag gggcgggact atggttgctg     2760

actaattgag atgcatgctt tgcatacttc tgcctgctgg ggagcctggg gactttccac     2820

acctggttgc tgactaattg agatgcatgc tttgcatact tctgcctgct ggggagcctg     2880

gggactttcc acaccctaac tgacacacat tccacagctg cattaatgaa tcggccaacg     2940

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     3000

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     3060

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     3120

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     3180

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     3240

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     3300

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     3360

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     3420

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     3480

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     3540

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     3600

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     3660

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     3720

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     3780

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     3840

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaa                      3884


<210>  13
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild type ITR, flip orientation

<400>  13
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  14
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild type ITR, flop orientation

<400>  14
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  15
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: B loop deleted ITR

<400>  15
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caa                                                                    123


<210>  16
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: C loop deleted ITR

<400>  16
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caa                                                                    123


<210>  17
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: A region deleted ITR

<400>  17
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  18
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: D region deleted ITR

<400>  18
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtg                      105


