                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF MICHIGAN
 
<120>  FLUORESCENT BIOSENSORS AND METHODS OF USE FOR DETECTING CELL 
       SIGNALING EVENTS

<130>  UM-39314-601

<150>  US 63/154,006
<151>  2021-02-26

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  1

Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
1               5                   10                  15      


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
            20                  25                  30          


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        35                  40                  45              


Asp Asn His Tyr Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn 
    50                  55                  60                  


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
65                  70                  75                  80  


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
                85                  90                  95      


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
            100                 105                 110         


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
        115                 120                 125             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
    130                 135                 140                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
145                 150                 155                 160 


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
                165                 170                 175     


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
            180                 185                 190         


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        195                 200                 205             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    210                 215                 220                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
225                 230                 235                 240 


Asn 
    


<210>  2
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  2

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile His Ser Gly Gly Ser Thr Asn Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Lys Asp Tyr Gly Ala Val Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  4

Leu Lys Glu Asp Ile 
1               5   


<210>  5
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  5

Phe Pro Leu Lys Met Arg Met Glu Arg Gln Gly Ala Pro 
1               5                   10              


<210>  6
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  6

Tyr Asn Ser His 
1               


<210>  7
<211>  381
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  7

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val Gln 
    370                 375                 380     


<210>  8
<211>  353
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  8

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Thr Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys 
    


<210>  9
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  9

Met Glu Pro Ala Pro Ser Ala Gly Ala Glu Leu Gln Pro Pro Leu Phe 
1               5                   10                  15      


Ala Asn Ala Ser Asp Ala Tyr Pro Ser Ala Cys Pro Ser Ala Gly Ala 
            20                  25                  30          


Asn Ala Ser Gly Pro Pro Gly Ala Arg Ser Ala Ser Ser Leu Ala Leu 
        35                  40                  45              


Ala Ile Ala Ile Thr Ala Leu Tyr Ser Ala Val Cys Ala Val Gly Leu 
    50                  55                  60                  


Leu Gly Asn Val Leu Val Met Phe Gly Ile Val Arg Tyr Thr Lys Met 
65                  70                  75                  80  


Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala 
                85                  90                  95      


Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Ala Lys Tyr Leu Met Glu 
            100                 105                 110         


Thr Trp Pro Phe Gly Glu Leu Leu Cys Lys Ala Val Leu Ser Ile Asp 
        115                 120                 125             


Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val 
    130                 135                 140                 


Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg 
145                 150                 155                 160 


Thr Pro Ala Lys Ala Lys Leu Ile Asn Ile Cys Ile Trp Val Leu Ala 
                165                 170                 175     


Ser Gly Val Gly Val Pro Ile Met Val Met Ala Val Thr Arg Pro Arg 
            180                 185                 190         


Asp Gly Ala Val Val Cys Met Leu Gln Phe Pro Ser Pro Ser Trp Tyr 
        195                 200                 205             


Trp Asp Thr Val Thr Lys Ile Cys Val Phe Leu Phe Ala Phe Val Val 
    210                 215                 220                 


Pro Ile Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Leu Leu Arg Leu 
225                 230                 235                 240 


Arg Ser Val Arg Leu Leu Ser Gly Ser Lys Glu Lys Asp Arg Ser Leu 
                245                 250                 255     


Arg Arg Ile Thr Arg Met Val Leu Val Val Val Gly Ala Phe Val Val 
            260                 265                 270         


Cys Trp Ala Pro Ile His Ile Phe Val Ile Val Trp Thr Leu Val Asp 
        275                 280                 285             


Ile Asp Arg Arg Asp Pro Leu Val Val Ala Ala Leu His Leu Cys Ile 
    290                 295                 300                 


Ala Leu Gly Tyr Ala Asn Ser Ser Leu Asn Pro Val Leu Tyr Ala Phe 
305                 310                 315                 320 


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Gln Leu Cys Arg Lys Pro 
                325                 330                 335     


Cys Gly Arg Pro Asp Pro Ser Ser Phe Ser Arg Ala Arg Glu Ala Thr 
            340                 345                 350         


Ala Arg Glu Arg Val Thr Ala Cys Thr Pro Ser Asp Gly Pro Gly Gly 
        355                 360                 365             


Gly Ala Ala Ala 
    370         


<210>  10
<211>  341
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  10

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys 
            340     


<210>  11
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  11

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Gly 
        355     


<210>  12
<211>  351
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  12

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Leu Lys Glu Leu Lys Glu 
            340                 345                 350     


<210>  13
<211>  400
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  13

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
385                 390                 395                 400 


<210>  14
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  14

Met Glu Pro Ala Pro Ser Ala Gly Ala Glu Leu Gln Pro Pro Leu Phe 
1               5                   10                  15      


Ala Asn Ala Ser Asp Ala Tyr Pro Ser Ala Cys Pro Ser Ala Gly Ala 
            20                  25                  30          


Asn Ala Ser Gly Pro Pro Gly Ala Arg Ser Ala Ser Ser Leu Ala Leu 
        35                  40                  45              


Ala Ile Ala Ile Thr Ala Leu Tyr Ser Ala Val Cys Ala Val Gly Leu 
    50                  55                  60                  


Leu Gly Asn Val Leu Val Met Phe Gly Ile Val Arg Tyr Thr Lys Met 
65                  70                  75                  80  


Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala 
                85                  90                  95      


Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Ala Lys Tyr Leu Met Glu 
            100                 105                 110         


Thr Trp Pro Phe Gly Glu Leu Leu Cys Lys Ala Val Leu Ser Ile Asp 
        115                 120                 125             


Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val 
    130                 135                 140                 


Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg 
145                 150                 155                 160 


Thr Pro Ala Lys Ala Lys Leu Ile Asn Ile Cys Ile Trp Val Leu Ala 
                165                 170                 175     


Ser Gly Val Gly Val Pro Ile Met Val Met Ala Val Thr Arg Pro Arg 
            180                 185                 190         


Asp Gly Ala Val Val Cys Met Leu Gln Phe Pro Ser Pro Ser Trp Tyr 
        195                 200                 205             


Trp Asp Thr Val Thr Lys Ile Cys Val Phe Leu Phe Ala Phe Val Val 
    210                 215                 220                 


Pro Ile Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Leu Leu Arg Leu 
225                 230                 235                 240 


Arg Ser Val Arg Leu Leu Ser Gly Ser Lys Glu Lys Asp Arg Ser Leu 
                245                 250                 255     


Arg Arg Ile Thr Arg Met Val Leu Val Val Val Gly Ala Phe Val Val 
            260                 265                 270         


Cys Trp Ala Pro Ile His Ile Phe Val Ile Val Trp Thr Leu Val Asp 
        275                 280                 285             


Ile Asp Arg Arg Asp Pro Leu Val Val Ala Ala Leu His Leu Cys Ile 
    290                 295                 300                 


Ala Leu Gly Tyr Ala Asn Ser Ser Leu Asn Pro Val Leu Tyr Ala Phe 
305                 310                 315                 320 


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Gln Leu Cys Phe Pro Leu 
                325                 330                 335     


Lys Met Arg Met Glu Arg Gln 
            340             


<210>  15
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  15

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala 
            20                  


<210>  16
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  16

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Asp Tyr Lys Asp Asp Asp Asp Ala 
            20                  25  


<210>  17
<211>  778
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  17

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Pro Ile Gln Ile Phe 
            20                  25                  30          


Arg Gly Glu Pro Gly Pro Thr Cys Ala Pro Ser Ala Cys Leu Pro Pro 
        35                  40                  45              


Asn Ser Ser Ala Trp Phe Pro Gly Trp Ala Glu Pro Asp Ser Asn Gly 
    50                  55                  60                  


Ser Ala Gly Ser Glu Asp Ala Gln Leu Glu Pro Ala His Ile Ser Pro 
65                  70                  75                  80  


Ala Ile Pro Val Ile Ile Thr Ala Val Tyr Ser Val Val Phe Val Val 
                85                  90                  95      


Gly Leu Val Gly Asn Ser Leu Val Met Phe Val Ile Ile Arg Tyr Thr 
            100                 105                 110         


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
        115                 120                 125             


Asp Ala Leu Val Thr Thr Thr Met Pro Phe Gln Ser Thr Val Tyr Leu 
    130                 135                 140                 


Met Asn Ser Trp Pro Phe Gly Asp Val Leu Cys Lys Ile Val Ile Ser 
145                 150                 155                 160 


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met 
                165                 170                 175     


Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp 
            180                 185                 190         


Phe Arg Thr Pro Leu Lys Ala Lys Ile Ile Asn Ile Cys Ile Trp Leu 
        195                 200                 205             


Leu Ser Ser Ser Val Gly Ile Ser Ala Ile Val Leu Gly Gly Thr Lys 
    210                 215                 220                 


Val Arg Glu Asp Val Asp Val Ile Glu Cys Ser Leu Gln Phe Pro Asp 
225                 230                 235                 240 


Asp Asp Tyr Ser Trp Trp Asp Leu Phe Met Lys Ile Cys Val Phe Ile 
                245                 250                 255     


Phe Ala Phe Val Ile Pro Val Leu Ile Ile Ile Val Cys Tyr Thr Leu 
            260                 265                 270         


Met Ile Leu Arg Leu Lys Ser Val Arg Leu Leu Ser Gly Ser Arg Glu 
        275                 280                 285             


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val 
    290                 295                 300                 


Ala Val Phe Val Val Cys Trp Thr Pro Ile His Ile Phe Ile Leu Val 
305                 310                 315                 320 


Glu Ala Leu Gly Ser Thr Ser His Ser Thr Ala Ala Leu Ser Ser Tyr 
                325                 330                 335     


Tyr Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Ser Leu Asn Pro Ile 
            340                 345                 350         


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Asp Phe 
        355                 360                 365             


Cys Phe Pro Leu Lys Met Arg Met Glu Arg Gln Ser Thr Ser Arg Val 
    370                 375                 380                 


Arg Asn Thr Val Gln Asp Pro Ala Tyr Leu Arg Asp Ile Asp Gly Met 
385                 390                 395                 400 


Asn Lys Pro Val Gln Gly Ala Pro Asn Val Tyr Ile Lys Ala Asp Lys 
                405                 410                 415     


Gln Lys Asn Gly Ile Lys Ala Asn Phe His Ile Arg His Asn Ile Glu 
            420                 425                 430         


Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Asn Thr Pro Ile 
        435                 440                 445             


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Val Gln 
    450                 455                 460                 


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
465                 470                 475                 480 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
                485                 490                 495     


Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu 
            500                 505                 510         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        515                 520                 525             


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    530                 535                 540                 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
545                 550                 555                 560 


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                565                 570                 575     


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            580                 585                 590         


Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        595                 600                 605             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    610                 615                 620                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
625                 630                 635                 640 


Ile Leu Gly His Lys Leu Glu Tyr Asn Leu Lys Glu Asp Ile Met Ala 
                645                 650                 655     


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
            660                 665                 670         


Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met 
        675                 680                 685             


Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser 
    690                 695                 700                 


Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp 
705                 710                 715                 720 


Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln 
                725                 730                 735     


Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            740                 745                 750         


Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp 
        755                 760                 765             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775             


<210>  18
<211>  761
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  18

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Ser Ala Ala Pro 
            20                  25                  30          


Thr Asn Ala Ser Asn Cys Thr Asp Ala Leu Ala Tyr Ser Ser Cys Ser 
        35                  40                  45              


Pro Ala Pro Ser Pro Gly Ser Trp Val Asn Leu Ser His Leu Asp Gly 
    50                  55                  60                  


Asn Leu Ser Asp Pro Cys Gly Pro Asn Arg Thr Asp Leu Gly Gly Arg 
65                  70                  75                  80  


Asp Ser Leu Cys Pro Pro Thr Gly Ser Pro Ser Met Ile Thr Ala Ile 
                85                  90                  95      


Thr Ile Met Ala Leu Tyr Ser Ile Val Cys Val Val Gly Leu Phe Gly 
            100                 105                 110         


Asn Phe Leu Val Met Tyr Val Ile Val Arg Tyr Thr Lys Met Lys Thr 
        115                 120                 125             


Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala 
    130                 135                 140                 


Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met Gly Thr Trp 
145                 150                 155                 160 


Pro Phe Gly Thr Thr Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr 
                165                 170                 175     


Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg 
            180                 185                 190         


Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro 
        195                 200                 205             


Arg Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile Leu Ser Ser Ala 
    210                 215                 220                 


Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr Arg Gln Gly 
225                 230                 235                 240 


Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp Tyr Trp Glu 
                245                 250                 255     


Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile Met Pro Val 
            260                 265                 270         


Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg Leu Lys Ser 
        275                 280                 285             


Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn Leu Arg Arg 
    290                 295                 300                 


Ile Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile Val Cys Trp 
305                 310                 315                 320 


Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Val Thr Ile Pro 
                325                 330                 335     


Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile Ala Leu Gly 
            340                 345                 350         


Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu 
        355                 360                 365             


Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Phe Pro Leu Lys Met Arg 
    370                 375                 380                 


Met Glu Arg Gln Gly Ala Pro Asn Val Tyr Ile Lys Ala Asp Lys Gln 
385                 390                 395                 400 


Lys Asn Gly Ile Lys Ala Asn Phe His Ile Arg His Asn Ile Glu Asp 
                405                 410                 415     


Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Asn Thr Pro Ile Gly 
            420                 425                 430         


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Val Gln Ser 
        435                 440                 445             


Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
    450                 455                 460                 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
465                 470                 475                 480 


Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe 
                485                 490                 495     


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
            500                 505                 510         


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
        515                 520                 525             


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
    530                 535                 540                 


Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser 
545                 550                 555                 560 


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
                565                 570                 575     


Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
            580                 585                 590         


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
        595                 600                 605             


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
    610                 615                 620                 


Leu Gly His Lys Leu Glu Tyr Asn Leu Lys Glu Asp Ile Met Ala Gln 
625                 630                 635                 640 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly Ser 
                645                 650                 655     


Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met Gly 
            660                 665                 670         


Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser Ile 
        675                 680                 685             


Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp Arg 
    690                 695                 700                 


Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg 
                725                 730                 735     


Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp Gly 
            740                 745                 750         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        755                 760     


<210>  19
<211>  769
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  19

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Glu Pro Ala Pro Ser Ala Gly 
            20                  25                  30          


Ala Glu Leu Gln Pro Pro Leu Phe Ala Asn Ala Ser Asp Ala Tyr Pro 
        35                  40                  45              


Ser Ala Cys Pro Ser Ala Gly Ala Asn Ala Ser Gly Pro Pro Gly Ala 
    50                  55                  60                  


Arg Ser Ala Ser Ser Leu Ala Leu Ala Ile Ala Ile Thr Ala Leu Tyr 
65                  70                  75                  80  


Ser Ala Val Cys Ala Val Gly Leu Leu Gly Asn Val Leu Val Met Phe 
                85                  90                  95      


Gly Ile Val Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile 
            100                 105                 110         


Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe 
        115                 120                 125             


Gln Ser Ala Lys Tyr Leu Met Glu Thr Trp Pro Phe Gly Glu Leu Leu 
    130                 135                 140                 


Cys Lys Ala Val Leu Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val Cys His 
                165                 170                 175     


Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Ala Lys Ala Lys Leu Ile 
            180                 185                 190         


Asn Ile Cys Ile Trp Val Leu Ala Ser Gly Val Gly Val Pro Ile Met 
        195                 200                 205             


Val Met Ala Val Thr Arg Pro Arg Asp Gly Ala Val Val Cys Met Leu 
    210                 215                 220                 


Gln Phe Pro Ser Pro Ser Trp Tyr Trp Asp Thr Val Thr Lys Ile Cys 
225                 230                 235                 240 


Val Phe Leu Phe Ala Phe Val Val Pro Ile Leu Ile Ile Thr Val Cys 
                245                 250                 255     


Tyr Gly Leu Met Leu Leu Arg Leu Arg Ser Val Arg Leu Leu Ser Gly 
            260                 265                 270         


Ser Lys Glu Lys Asp Arg Ser Leu Arg Arg Ile Thr Arg Met Val Leu 
        275                 280                 285             


Val Val Val Gly Ala Phe Val Val Cys Trp Ala Pro Ile His Ile Phe 
    290                 295                 300                 


Val Ile Val Trp Thr Leu Val Asp Ile Asp Arg Arg Asp Pro Leu Val 
305                 310                 315                 320 


Val Ala Ala Leu His Leu Cys Ile Ala Leu Gly Tyr Ala Asn Ser Ser 
                325                 330                 335     


Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys 
            340                 345                 350         


Phe Arg Gln Leu Cys Arg Lys Pro Cys Gly Arg Pro Asp Pro Ser Ser 
        355                 360                 365             


Phe Ser Arg Ala Arg Glu Ala Thr Ala Arg Glu Arg Val Thr Ala Cys 
    370                 375                 380                 


Thr Pro Ser Asp Gly Pro Gly Gly Gly Ala Ala Ala Gly Ala Pro Asn 
385                 390                 395                 400 


Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
                405                 410                 415     


His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His 
            420                 425                 430         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        435                 440                 445             


Asn His Tyr Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu 
    450                 455                 460                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
465                 470                 475                 480 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
                485                 490                 495     


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
            500                 505                 510         


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
        515                 520                 525             


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
    530                 535                 540                 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
545                 550                 555                 560 


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
                565                 570                 575     


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
            580                 585                 590         


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
        595                 600                 605             


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
    610                 615                 620                 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
625                 630                 635                 640 


Leu Lys Glu Asp Ile Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
                645                 650                 655     


Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser 
            660                 665                 670         


Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys 
        675                 680                 685             


Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr 
    690                 695                 700                 


Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala 
705                 710                 715                 720 


Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
                725                 730                 735     


Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser 
            740                 745                 750         


Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        755                 760                 765             


Ser 
    


<210>  20
<211>  871
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  20

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Gly Gln Pro Gly Asn Gly Ser 
            20                  25                  30          


Ala Phe Leu Leu Ala Pro Asn Arg Ser His Ala Pro Asp His Asp Val 
        35                  40                  45              


Thr Gln Gln Arg Asp Glu Val Trp Val Val Gly Met Gly Ile Val Met 
    50                  55                  60                  


Ser Leu Ile Val Leu Ala Ile Val Phe Gly Asn Val Leu Val Ile Thr 
65                  70                  75                  80  


Ala Ile Ala Lys Phe Glu Arg Leu Gln Thr Val Thr Asn Tyr Phe Ile 
                85                  90                  95      


Thr Ser Leu Ala Cys Ala Asp Leu Val Met Gly Leu Ala Val Val Pro 
            100                 105                 110         


Phe Gly Ala Ala His Ile Leu Met Lys Met Trp Thr Phe Gly Asn Phe 
        115                 120                 125             


Trp Cys Glu Phe Trp Thr Ser Ile Asp Val Leu Cys Val Thr Ala Ser 
    130                 135                 140                 


Ile Glu Thr Leu Cys Val Ile Ala Val Asp Arg Tyr Phe Ala Ile Thr 
145                 150                 155                 160 


Ser Pro Phe Lys Tyr Gln Ser Leu Leu Thr Lys Asn Lys Ala Arg Val 
                165                 170                 175     


Ile Ile Leu Met Val Trp Ile Val Ser Gly Leu Thr Ser Phe Leu Pro 
            180                 185                 190         


Ile Gln Met His Trp Tyr Arg Ala Thr His Gln Glu Ala Ile Asn Cys 
        195                 200                 205             


Tyr Ala Asn Glu Thr Cys Cys Asp Phe Phe Thr Asn Gln Ala Tyr Ala 
    210                 215                 220                 


Ile Ala Ser Ser Ile Val Ser Phe Tyr Val Pro Leu Val Ile Met Val 
225                 230                 235                 240 


Phe Val Tyr Ser Arg Val Phe Gln Glu Ala Lys Arg Gln Leu Gln Lys 
                245                 250                 255     


Ile Asp Lys Ser Glu Gly Arg Phe His Val Gln Asn Leu Ser Gln Val 
            260                 265                 270         


Glu Gln Asp Gly Arg Thr Gly His Gly Leu Arg Arg Ser Ser Lys Phe 
        275                 280                 285             


Cys Leu Lys Glu His Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly 
    290                 295                 300                 


Thr Phe Thr Leu Cys Trp Leu Pro Phe Phe Ile Val Asn Ile Val His 
305                 310                 315                 320 


Val Ile Gln Asp Asn Leu Ile Arg Lys Glu Val Tyr Ile Leu Leu Asn 
                325                 330                 335     


Trp Ile Gly Tyr Val Asn Ser Gly Phe Asn Pro Leu Ile Tyr Cys Arg 
            340                 345                 350         


Ser Pro Asp Phe Arg Ile Ala Phe Gln Glu Leu Leu Cys Phe Pro Leu 
        355                 360                 365             


Lys Met Arg Met Glu Arg Gln Gly Ala Pro Asn Val Tyr Ile Lys Ala 
    370                 375                 380                 


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe His Ile Arg His Asn 
385                 390                 395                 400 


Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Asn Thr 
                405                 410                 415     


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
            420                 425                 430         


Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
        435                 440                 445             


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
    450                 455                 460                 


Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu 
465                 470                 475                 480 


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
                485                 490                 495     


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
            500                 505                 510         


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
        515                 520                 525             


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
    530                 535                 540                 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
545                 550                 555                 560 


Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe Lys 
                565                 570                 575     


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
            580                 585                 590         


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
        595                 600                 605             


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Leu Lys Glu Asp Ile 
    610                 615                 620                 


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
625                 630                 635                 640 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
                645                 650                 655     


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            660                 665                 670         


Ala Ala Ile His Ser Gly Gly Ser Thr Asn Tyr Ala Asn Ser Val Lys 
        675                 680                 685             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Val Tyr Leu 
    690                 695                 700                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
705                 710                 715                 720 


Val Lys Asp Tyr Gly Ala Val Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln 
                725                 730                 735     


Gly Thr Gln Val Thr Val Ser Ser Leu Lys Glu Met Ala Gln Val Gln 
            740                 745                 750         


Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly Ser Leu Arg 
        755                 760                 765             


Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe 
    770                 775                 780                 


Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser Ile Thr Trp 
785                 790                 795                 800 


Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr 
                805                 810                 815     


Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            820                 825                 830         


Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro 
        835                 840                 845             


Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly 
    850                 855                 860                 


Thr Gln Val Thr Val Ser Ser 
865                 870     


<210>  21
<211>  752
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  21

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Pro Ile Gln Ile Phe 
            20                  25                  30          


Arg Gly Glu Pro Gly Pro Thr Cys Ala Pro Ser Ala Cys Leu Pro Pro 
        35                  40                  45              


Asn Ser Ser Ala Trp Phe Pro Gly Trp Ala Glu Pro Asp Ser Asn Gly 
    50                  55                  60                  


Ser Ala Gly Ser Glu Asp Ala Gln Leu Glu Pro Ala His Ile Ser Pro 
65                  70                  75                  80  


Ala Ile Pro Val Ile Ile Thr Ala Val Tyr Ser Val Val Phe Val Val 
                85                  90                  95      


Gly Leu Val Gly Asn Ser Leu Val Met Phe Val Ile Ile Arg Tyr Thr 
            100                 105                 110         


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
        115                 120                 125             


Asp Ala Leu Val Thr Thr Thr Met Pro Phe Gln Ser Thr Val Tyr Leu 
    130                 135                 140                 


Met Asn Ser Trp Pro Phe Gly Asp Val Leu Cys Lys Ile Val Ile Ser 
145                 150                 155                 160 


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met 
                165                 170                 175     


Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp 
            180                 185                 190         


Phe Arg Thr Pro Leu Lys Ala Lys Ile Ile Asn Ile Cys Ile Trp Leu 
        195                 200                 205             


Leu Ser Ser Ser Val Gly Ile Ser Ala Ile Val Leu Gly Gly Thr Lys 
    210                 215                 220                 


Val Arg Glu Asp Val Asp Val Ile Glu Cys Ser Leu Gln Phe Pro Asp 
225                 230                 235                 240 


Asp Asp Tyr Ser Trp Trp Asp Leu Phe Met Lys Ile Cys Val Phe Ile 
                245                 250                 255     


Phe Ala Phe Val Ile Pro Val Leu Ile Ile Ile Val Cys Tyr Thr Leu 
            260                 265                 270         


Met Ile Leu Arg Leu Lys Ser Val Arg Leu Leu Ser Gly Ser Arg Glu 
        275                 280                 285             


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val 
    290                 295                 300                 


Ala Val Phe Val Val Cys Trp Thr Pro Ile His Ile Phe Ile Leu Val 
305                 310                 315                 320 


Glu Ala Leu Gly Ser Thr Ser His Ser Thr Ala Ala Leu Ser Ser Tyr 
                325                 330                 335     


Tyr Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Ser Leu Asn Pro Ile 
            340                 345                 350         


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Asp Phe 
        355                 360                 365             


Cys Phe Pro Leu Lys Met Arg Met Glu Arg Gln Gly Ala Pro Asn Val 
    370                 375                 380                 


Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe His 
385                 390                 395                 400 


Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr 
                405                 410                 415     


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
            420                 425                 430         


His Tyr Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys 
        435                 440                 445             


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
    450                 455                 460                 


Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val 
465                 470                 475                 480 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
                485                 490                 495     


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            500                 505                 510         


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        515                 520                 525             


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
    530                 535                 540                 


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
545                 550                 555                 560 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr 
                565                 570                 575     


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            580                 585                 590         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        595                 600                 605             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Leu 
    610                 615                 620                 


Lys Glu Asp Ile Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
625                 630                 635                 640 


Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser Glu 
                645                 650                 655     


Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu 
            660                 665                 670         


Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr 
        675                 680                 685             


Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala Asn 
    690                 695                 700                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala 
705                 710                 715                 720 


Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro 
                725                 730                 735     


Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            740                 745                 750         


<210>  22
<211>  748
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  22

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Pro Ile Gln Ile Phe 
            20                  25                  30          


Arg Gly Glu Pro Gly Pro Thr Cys Ala Pro Ser Ala Cys Leu Pro Pro 
        35                  40                  45              


Asn Ser Ser Ala Trp Phe Pro Gly Trp Ala Glu Pro Asp Ser Asn Gly 
    50                  55                  60                  


Ser Ala Gly Ser Glu Asp Ala Gln Leu Glu Pro Ala His Ile Ser Pro 
65                  70                  75                  80  


Ala Ile Pro Val Ile Ile Thr Ala Val Tyr Ser Val Val Phe Val Val 
                85                  90                  95      


Gly Leu Val Gly Asn Ser Leu Val Met Phe Val Ile Ile Arg Tyr Thr 
            100                 105                 110         


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
        115                 120                 125             


Asp Ala Leu Val Thr Thr Thr Met Pro Phe Gln Ser Thr Val Tyr Leu 
    130                 135                 140                 


Met Asn Ser Trp Pro Phe Gly Asp Val Leu Cys Lys Ile Val Ile Ser 
145                 150                 155                 160 


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met 
                165                 170                 175     


Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp 
            180                 185                 190         


Phe Arg Thr Pro Leu Lys Ala Lys Ile Ile Asn Ile Cys Ile Trp Leu 
        195                 200                 205             


Leu Ser Ser Ser Val Gly Ile Ser Ala Ile Val Leu Gly Gly Thr Lys 
    210                 215                 220                 


Val Arg Glu Asp Val Asp Val Ile Glu Cys Ser Leu Gln Phe Pro Asp 
225                 230                 235                 240 


Asp Asp Tyr Ser Trp Trp Asp Leu Phe Met Lys Ile Cys Val Phe Ile 
                245                 250                 255     


Phe Ala Phe Val Ile Pro Val Leu Ile Ile Ile Val Cys Tyr Thr Leu 
            260                 265                 270         


Met Ile Leu Arg Leu Lys Ser Val Arg Leu Leu Ser Gly Ser Arg Glu 
        275                 280                 285             


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val 
    290                 295                 300                 


Ala Val Phe Val Val Cys Trp Thr Pro Ile His Ile Phe Ile Leu Val 
305                 310                 315                 320 


Glu Ala Leu Gly Ser Thr Ser His Ser Thr Ala Ala Leu Ser Ser Tyr 
                325                 330                 335     


Tyr Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Ser Leu Asn Pro Ile 
            340                 345                 350         


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Asp Phe 
        355                 360                 365             


Cys Leu Lys Glu Leu Lys Glu Gly Ala Pro Asn Val Tyr Ile Lys Ala 
    370                 375                 380                 


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe His Ile Arg His Asn 
385                 390                 395                 400 


Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Asn Thr 
                405                 410                 415     


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
            420                 425                 430         


Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
        435                 440                 445             


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
    450                 455                 460                 


Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly Glu 
465                 470                 475                 480 


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
                485                 490                 495     


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
            500                 505                 510         


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
        515                 520                 525             


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln 
    530                 535                 540                 


Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
545                 550                 555                 560 


Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe Lys 
                565                 570                 575     


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
            580                 585                 590         


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
        595                 600                 605             


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Leu Lys Glu Asp Ile 
    610                 615                 620                 


Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro 
625                 630                 635                 640 


Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr 
                645                 650                 655     


Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
            660                 665                 670         


Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val 
        675                 680                 685             


Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr 
    690                 695                 700                 


Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys 
705                 710                 715                 720 


Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
                725                 730                 735     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            740                 745             


<210>  23
<211>  798
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  23

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Ser Ala Ala Pro Thr 
            20                  25                  30          


Asn Ala Ser Asn Cys Thr Asp Ala Leu Ala Tyr Ser Ser Cys Ser Pro 
        35                  40                  45              


Ala Pro Ser Pro Gly Ser Trp Val Asn Leu Ser His Leu Asp Gly Asn 
    50                  55                  60                  


Leu Ser Asp Pro Cys Gly Pro Asn Arg Thr Asp Leu Gly Gly Arg Asp 
65                  70                  75                  80  


Ser Leu Cys Pro Pro Thr Gly Ser Pro Ser Met Ile Thr Ala Ile Thr 
                85                  90                  95      


Ile Met Ala Leu Tyr Ser Ile Val Cys Val Val Gly Leu Phe Gly Asn 
            100                 105                 110         


Phe Leu Val Met Tyr Val Ile Val Arg Tyr Thr Lys Met Lys Thr Ala 
        115                 120                 125             


Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala Thr 
    130                 135                 140                 


Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met Gly Thr Trp Pro 
145                 150                 155                 160 


Phe Gly Thr Ile Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn 
                165                 170                 175     


Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg Tyr 
            180                 185                 190         


Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Arg 
        195                 200                 205             


Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile Leu Ser Ser Ala Ile 
    210                 215                 220                 


Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr Arg Gln Gly Ser 
225                 230                 235                 240 


Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp Tyr Trp Glu Asn 
                245                 250                 255     


Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile Met Pro Val Leu 
            260                 265                 270         


Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg Leu Lys Ser Val 
        275                 280                 285             


Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn Leu Arg Arg Ile 
    290                 295                 300                 


Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile Val Cys Trp Thr 
305                 310                 315                 320 


Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Val Thr Ile Pro Glu 
                325                 330                 335     


Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile Ala Leu Gly Tyr 
            340                 345                 350         


Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu Asn 
        355                 360                 365             


Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile Pro Thr Ser Ser Asn Ile 
    370                 375                 380                 


Glu Gln Gln Asn Ser Thr Arg Ile Arg Gln Asn Thr Arg Asp His Pro 
385                 390                 395                 400 


Ser Thr Ala Asn Thr Val Asp Arg Thr Asn His Gln Leu Glu Asn Leu 
                405                 410                 415     


Glu Ala Glu Thr Ala Pro Leu Pro Gly Ala Pro Asn Val Tyr Ile Lys 
            420                 425                 430         


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe His Ile Arg His 
        435                 440                 445             


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Asn 
    450                 455                 460                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
465                 470                 475                 480 


Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                485                 490                 495     


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
            500                 505                 510         


Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly 
        515                 520                 525             


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
    530                 535                 540                 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
545                 550                 555                 560 


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
                565                 570                 575     


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
            580                 585                 590         


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
        595                 600                 605             


Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe 
    610                 615                 620                 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
625                 630                 635                 640 


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
                645                 650                 655     


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Leu Lys Glu Asp 
            660                 665                 670         


Ile Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly 
        675                 680                 685             


Gly Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro 
    690                 695                 700                 


Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
705                 710                 715                 720 


Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala 
                725                 730                 735     


Asp Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu 
            740                 745                 750         


Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        755                 760                 765             


Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr 
    770                 775                 780                 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
785                 790                 795             


<210>  24
<211>  740
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  24

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Glu Pro Ala Pro Ser Ala Gly 
            20                  25                  30          


Ala Glu Leu Gln Pro Pro Leu Phe Ala Asn Ala Ser Asp Ala Tyr Pro 
        35                  40                  45              


Ser Ala Cys Pro Ser Ala Gly Ala Asn Ala Ser Gly Pro Pro Gly Ala 
    50                  55                  60                  


Arg Ser Ala Ser Ser Leu Ala Leu Ala Ile Ala Ile Thr Ala Leu Tyr 
65                  70                  75                  80  


Ser Ala Val Cys Ala Val Gly Leu Leu Gly Asn Val Leu Val Met Phe 
                85                  90                  95      


Gly Ile Val Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile 
            100                 105                 110         


Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe 
        115                 120                 125             


Gln Ser Ala Lys Tyr Leu Met Glu Thr Trp Pro Phe Gly Glu Leu Leu 
    130                 135                 140                 


Cys Lys Ala Val Leu Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val Cys His 
                165                 170                 175     


Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Ala Lys Ala Lys Leu Ile 
            180                 185                 190         


Asn Ile Cys Ile Trp Val Leu Ala Ser Gly Val Gly Val Pro Ile Met 
        195                 200                 205             


Val Met Ala Val Thr Arg Pro Arg Asp Gly Ala Val Val Cys Met Leu 
    210                 215                 220                 


Gln Phe Pro Ser Pro Ser Trp Tyr Trp Asp Thr Val Thr Lys Ile Cys 
225                 230                 235                 240 


Val Phe Leu Phe Ala Phe Val Val Pro Ile Leu Ile Ile Thr Val Cys 
                245                 250                 255     


Tyr Gly Leu Met Leu Leu Arg Leu Arg Ser Val Arg Leu Leu Ser Gly 
            260                 265                 270         


Ser Lys Glu Lys Asp Arg Ser Leu Arg Arg Ile Thr Arg Met Val Leu 
        275                 280                 285             


Val Val Val Gly Ala Phe Val Val Cys Trp Ala Pro Ile His Ile Phe 
    290                 295                 300                 


Val Ile Val Trp Thr Leu Val Asp Ile Asp Arg Arg Asp Pro Leu Val 
305                 310                 315                 320 


Val Ala Ala Leu His Leu Cys Ile Ala Leu Gly Tyr Ala Asn Ser Ser 
                325                 330                 335     


Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys 
            340                 345                 350         


Phe Arg Gln Leu Cys Phe Pro Leu Lys Met Arg Met Glu Arg Gln Gly 
        355                 360                 365             


Ala Pro Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys 
    370                 375                 380                 


Ala Asn Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu 
385                 390                 395                 400 


Ala Tyr His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                405                 410                 415     


Leu Pro Asp Asn His Tyr Leu Ser Val Gln Ser Lys Leu Ser Lys Asp 
            420                 425                 430         


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
        435                 440                 445             


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly 
    450                 455                 460                 


Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
465                 470                 475                 480 


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
                485                 490                 495     


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
            500                 505                 510         


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
        515                 520                 525             


Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
    530                 535                 540                 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile 
545                 550                 555                 560 


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
                565                 570                 575     


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
            580                 585                 590         


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
        595                 600                 605             


Glu Tyr Asn Leu Lys Glu Asp Ile Met Ala Gln Val Gln Leu Val Glu 
    610                 615                 620                 


Ser Gly Gly Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys 
625                 630                 635                 640 


Val Asp Ser Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala 
                645                 650                 655     


Pro Gly Lys Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile 
            660                 665                 670         


Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg 
        675                 680                 685             


Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln 
705                 710                 715                 720 


Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val 
                725                 730                 735     


Thr Val Ser Ser 
            740 


<210>  25
<211>  765
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  25

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Ser Ala Ala Pro 
            20                  25                  30          


Thr Asn Ala Ser Asn Cys Thr Asp Ala Leu Ala Tyr Ser Ser Cys Ser 
        35                  40                  45              


Pro Ala Pro Ser Pro Gly Ser Trp Val Asn Leu Ser His Leu Asp Gly 
    50                  55                  60                  


Asn Leu Ser Asp Pro Cys Gly Pro Asn Arg Thr Asp Leu Gly Gly Arg 
65                  70                  75                  80  


Asp Ser Leu Cys Pro Pro Thr Gly Ser Pro Ser Met Ile Thr Ala Ile 
                85                  90                  95      


Thr Ile Met Ala Leu Tyr Ser Ile Val Cys Val Val Gly Leu Phe Gly 
            100                 105                 110         


Asn Phe Leu Val Met Tyr Val Ile Val Arg Tyr Thr Lys Met Lys Thr 
        115                 120                 125             


Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala 
    130                 135                 140                 


Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met Gly Thr Trp 
145                 150                 155                 160 


Pro Phe Gly Thr Thr Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr 
                165                 170                 175     


Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg 
            180                 185                 190         


Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro 
        195                 200                 205             


Arg Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile Leu Ser Ser Ala 
    210                 215                 220                 


Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr Arg Gln Gly 
225                 230                 235                 240 


Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp Tyr Trp Glu 
                245                 250                 255     


Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile Met Pro Val 
            260                 265                 270         


Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg Leu Lys Ser 
        275                 280                 285             


Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn Leu Arg Arg 
    290                 295                 300                 


Ile Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile Val Cys Trp 
305                 310                 315                 320 


Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Val Thr Ile Pro 
                325                 330                 335     


Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile Ala Leu Gly 
            340                 345                 350         


Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu 
        355                 360                 365             


Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Phe Pro Leu Lys Met Arg 
    370                 375                 380                 


Met Glu Arg Gln Gly Ala Pro Tyr Asn Ser His Asn Val Tyr Ile Lys 
385                 390                 395                 400 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe His Ile Arg His 
                405                 410                 415     


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Asn 
            420                 425                 430         


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
        435                 440                 445             


Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
    450                 455                 460                 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
465                 470                 475                 480 


Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys Gly 
                485                 490                 495     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            500                 505                 510         


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        515                 520                 525             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
    530                 535                 540                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
545                 550                 555                 560 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                565                 570                 575     


Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe 
            580                 585                 590         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        595                 600                 605             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    610                 615                 620                 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Leu Lys Glu Asp 
625                 630                 635                 640 


Ile Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg 
                645                 650                 655     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser 
            660                 665                 670         


Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe 
        675                 680                 685             


Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser 
    690                 695                 700                 


Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu 
705                 710                 715                 720 


Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr 
                725                 730                 735     


Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr 
            740                 745                 750         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        755                 760                 765 


<210>  26
<211>  412
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  26

Arg Arg Lys Trp Ile Lys Ala Gly His Ala Val Arg Ala Ile Gly Arg 
1               5                   10                  15      


Leu Ser Ser Pro Val Val Ser Glu Arg Met Tyr Pro Glu Asp Gly Val 
            20                  25                  30          


Leu Lys Ser Glu Ile Lys Lys Gly Leu Arg Leu Lys Asp Gly Gly His 
        35                  40                  45              


Tyr Ala Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
    50                  55                  60                  


Leu Pro Gly Ala Tyr Ile Val Asp Ile Lys Leu Asp Ile Val Ser His 
65                  70                  75                  80  


Asn Glu Asp Tyr Thr Ile Val Glu Gln Cys Glu Arg Ala Glu Gly Arg 
                85                  90                  95      


His Pro Thr Gly Gly Arg Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly 
            100                 105                 110         


Ser Leu Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
        115                 120                 125             


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
    130                 135                 140                 


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Ala Phe Gln 
145                 150                 155                 160 


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
                165                 170                 175     


Asp Ile Leu Ser Pro Gln Phe Thr Tyr Gly Ser Lys Ala Tyr Ile Lys 
            180                 185                 190         


His Pro Ala Asp Ile Pro Asp Tyr Phe Lys Leu Ser Phe Pro Glu Gly 
        195                 200                 205             


Phe Arg Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Ile Ile His 
    210                 215                 220                 


Val Asn Gln Asp Ser Ser Leu Gln Asp Gly Val Phe Ile Tyr Lys Val 
225                 230                 235                 240 


Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys 
                245                 250                 255     


Lys Thr Met Gly Trp Glu Ala Thr Arg Asp Gln Leu Thr Glu Glu Gln 
            260                 265                 270         


Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp 
        275                 280                 285             


Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr Val Leu Arg Ser Leu Gly 
    290                 295                 300                 


Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met Ile Asn Glu Val Asp 
305                 310                 315                 320 


Ala Asp Gly Asp Gly Thr Phe Asp Phe Pro Glu Phe Leu Thr Met Met 
                325                 330                 335     


Ala Arg Arg Met Asn Asp Thr Asp Ser Glu Val Glu Ile Arg Glu Ala 
            340                 345                 350         


Phe Arg Val Phe Asp Asn Asp Gly Asn Gly Tyr Ile Gly Ala Ala Glu 
        355                 360                 365             


Leu Arg His Val Met Thr Asp Leu Gly Glu Lys Leu Thr Asp Glu Glu 
    370                 375                 380                 


Val Asp Glu Met Ile Arg Val Ala Asp Ile Asp Gly Asp Gly Gln Val 
385                 390                 395                 400 


Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala Lys 
                405                 410         


<210>  27
<211>  950
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  27

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Pro Ile Gln Ile Phe 
            20                  25                  30          


Arg Gly Glu Pro Gly Pro Thr Cys Ala Pro Ser Ala Cys Leu Pro Pro 
        35                  40                  45              


Asn Ser Ser Ala Trp Phe Pro Gly Trp Ala Glu Pro Asp Ser Asn Gly 
    50                  55                  60                  


Ser Ala Gly Ser Glu Asp Ala Gln Leu Glu Pro Ala His Ile Ser Pro 
65                  70                  75                  80  


Ala Ile Pro Val Ile Ile Thr Ala Val Tyr Ser Val Val Phe Val Val 
                85                  90                  95      


Gly Leu Val Gly Asn Ser Leu Val Met Phe Val Ile Ile Arg Tyr Thr 
            100                 105                 110         


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
        115                 120                 125             


Asp Ala Leu Val Thr Thr Thr Met Pro Phe Gln Ser Thr Val Tyr Leu 
    130                 135                 140                 


Met Asn Ser Trp Pro Phe Gly Asp Val Leu Cys Lys Ile Val Ile Ser 
145                 150                 155                 160 


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met 
                165                 170                 175     


Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp 
            180                 185                 190         


Phe Arg Thr Pro Leu Lys Ala Lys Ile Ile Asn Ile Cys Ile Trp Leu 
        195                 200                 205             


Leu Ser Ser Ser Val Gly Ile Ser Ala Ile Val Leu Gly Gly Thr Lys 
    210                 215                 220                 


Val Arg Glu Asp Val Asp Val Ile Glu Cys Ser Leu Gln Phe Pro Asp 
225                 230                 235                 240 


Asp Asp Tyr Ser Trp Trp Asp Leu Phe Met Lys Ile Cys Val Phe Ile 
                245                 250                 255     


Phe Ala Phe Val Ile Pro Val Leu Ile Ile Ile Val Cys Tyr Thr Leu 
            260                 265                 270         


Met Ile Leu Arg Leu Lys Ser Val Arg Leu Leu Ser Gly Ser Arg Glu 
        275                 280                 285             


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val 
    290                 295                 300                 


Ala Val Phe Val Val Cys Trp Thr Pro Ile His Ile Phe Ile Leu Val 
305                 310                 315                 320 


Glu Ala Leu Gly Ser Thr Ser His Ser Thr Ala Ala Leu Ser Ser Tyr 
                325                 330                 335     


Tyr Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Ser Leu Asn Pro Ile 
            340                 345                 350         


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Asp Phe 
        355                 360                 365             


Cys Phe Pro Leu Lys Met Arg Met Glu Arg Gln Ser Thr Ser Arg Val 
    370                 375                 380                 


Arg Asn Thr Val Gln Asp Pro Ala Tyr Leu Arg Asp Ile Asp Gly Met 
385                 390                 395                 400 


Asn Lys Pro Val Gln Ala Ser Met Val Asp Ser Ser Arg Arg Lys Trp 
                405                 410                 415     


Ile Lys Ala Gly His Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Pro 
            420                 425                 430         


Val Val Ser Glu Arg Met Tyr Pro Glu Asp Gly Val Leu Lys Ser Glu 
        435                 440                 445             


Ile Lys Lys Gly Leu Arg Leu Lys Asp Gly Gly His Tyr Ala Ala Glu 
    450                 455                 460                 


Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala 
465                 470                 475                 480 


Tyr Ile Val Asp Ile Lys Leu Asp Ile Val Ser His Asn Glu Asp Tyr 
                485                 490                 495     


Thr Ile Val Glu Gln Cys Glu Arg Ala Glu Gly Arg His Pro Thr Gly 
            500                 505                 510         


Gly Arg Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Leu Val Ser 
        515                 520                 525             


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
    530                 535                 540                 


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
545                 550                 555                 560 


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Ala Phe Gln Thr Ala Lys Leu 
                565                 570                 575     


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
            580                 585                 590         


Pro Gln Phe Thr Tyr Gly Ser Lys Ala Tyr Ile Lys His Pro Ala Asp 
        595                 600                 605             


Ile Pro Asp Tyr Phe Lys Leu Ser Phe Pro Glu Gly Phe Arg Trp Glu 
    610                 615                 620                 


Arg Val Met Asn Phe Glu Asp Gly Gly Ile Ile His Val Asn Gln Asp 
625                 630                 635                 640 


Ser Ser Leu Gln Asp Gly Val Phe Ile Tyr Lys Val Lys Leu Arg Gly 
                645                 650                 655     


Thr Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
            660                 665                 670         


Trp Glu Ala Thr Arg Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe 
        675                 680                 685             


Lys Glu Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr 
    690                 695                 700                 


Thr Lys Glu Leu Gly Thr Val Leu Arg Ser Leu Gly Gln Asn Pro Thr 
705                 710                 715                 720 


Glu Ala Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp 
                725                 730                 735     


Gly Thr Phe Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Arg Met 
            740                 745                 750         


Asn Asp Thr Asp Ser Glu Val Glu Ile Arg Glu Ala Phe Arg Val Phe 
        755                 760                 765             


Asp Asn Asp Gly Asn Gly Tyr Ile Gly Ala Ala Glu Leu Arg His Val 
    770                 775                 780                 


Met Thr Asp Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met 
785                 790                 795                 800 


Ile Arg Val Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu 
                805                 810                 815     


Phe Val Gln Met Met Thr Ala Lys Asp Ile Met Ala Gln Val Gln Leu 
            820                 825                 830         


Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu 
        835                 840                 845             


Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg 
    850                 855                 860                 


Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser 
865                 870                 875                 880 


Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr 
                885                 890                 895     


Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            900                 905                 910         


Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val 
        915                 920                 925             


Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
    930                 935                 940                 


Gln Val Thr Val Ser Ser 
945                 950 


<210>  28
<211>  933
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  28

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Ser Ser Ala Ala Pro 
            20                  25                  30          


Thr Asn Ala Ser Asn Cys Thr Asp Ala Leu Ala Tyr Ser Ser Cys Ser 
        35                  40                  45              


Pro Ala Pro Ser Pro Gly Ser Trp Val Asn Leu Ser His Leu Asp Gly 
    50                  55                  60                  


Asn Leu Ser Asp Pro Cys Gly Pro Asn Arg Thr Asp Leu Gly Gly Arg 
65                  70                  75                  80  


Asp Ser Leu Cys Pro Pro Thr Gly Ser Pro Ser Met Ile Thr Ala Ile 
                85                  90                  95      


Thr Ile Met Ala Leu Tyr Ser Ile Val Cys Val Val Gly Leu Phe Gly 
            100                 105                 110         


Asn Phe Leu Val Met Tyr Val Ile Val Arg Tyr Thr Lys Met Lys Thr 
        115                 120                 125             


Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala 
    130                 135                 140                 


Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met Gly Thr Trp 
145                 150                 155                 160 


Pro Phe Gly Thr Thr Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr 
                165                 170                 175     


Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg 
            180                 185                 190         


Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro 
        195                 200                 205             


Arg Asn Ala Lys Ile Ile Asn Val Cys Asn Trp Ile Leu Ser Ser Ala 
    210                 215                 220                 


Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr Arg Gln Gly 
225                 230                 235                 240 


Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp Tyr Trp Glu 
                245                 250                 255     


Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile Met Pro Val 
            260                 265                 270         


Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg Leu Lys Ser 
        275                 280                 285             


Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn Leu Arg Arg 
    290                 295                 300                 


Ile Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile Val Cys Trp 
305                 310                 315                 320 


Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Val Thr Ile Pro 
                325                 330                 335     


Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile Ala Leu Gly 
            340                 345                 350         


Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu 
        355                 360                 365             


Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Phe Pro Leu Lys Met Arg 
    370                 375                 380                 


Met Glu Arg Gln Ala Ser Met Val Asp Ser Ser Arg Arg Lys Trp Ile 
385                 390                 395                 400 


Lys Ala Gly His Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Pro Val 
                405                 410                 415     


Val Ser Glu Arg Met Tyr Pro Glu Asp Gly Val Leu Lys Ser Glu Ile 
            420                 425                 430         


Lys Lys Gly Leu Arg Leu Lys Asp Gly Gly His Tyr Ala Ala Glu Val 
        435                 440                 445             


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
    450                 455                 460                 


Ile Val Asp Ile Lys Leu Asp Ile Val Ser His Asn Glu Asp Tyr Thr 
465                 470                 475                 480 


Ile Val Glu Gln Cys Glu Arg Ala Glu Gly Arg His Pro Thr Gly Gly 
                485                 490                 495     


Arg Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Leu Val Ser Lys 
            500                 505                 510         


Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys 
        515                 520                 525             


Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly 
    530                 535                 540                 


Glu Gly Glu Gly Arg Pro Tyr Glu Ala Phe Gln Thr Ala Lys Leu Lys 
545                 550                 555                 560 


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
                565                 570                 575     


Gln Phe Thr Tyr Gly Ser Lys Ala Tyr Ile Lys His Pro Ala Asp Ile 
            580                 585                 590         


Pro Asp Tyr Phe Lys Leu Ser Phe Pro Glu Gly Phe Arg Trp Glu Arg 
        595                 600                 605             


Val Met Asn Phe Glu Asp Gly Gly Ile Ile His Val Asn Gln Asp Ser 
    610                 615                 620                 


Ser Leu Gln Asp Gly Val Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr 
625                 630                 635                 640 


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
                645                 650                 655     


Glu Ala Thr Arg Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys 
            660                 665                 670         


Glu Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr 
        675                 680                 685             


Lys Glu Leu Gly Thr Val Leu Arg Ser Leu Gly Gln Asn Pro Thr Glu 
    690                 695                 700                 


Ala Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly 
705                 710                 715                 720 


Thr Phe Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Arg Met Asn 
                725                 730                 735     


Asp Thr Asp Ser Glu Val Glu Ile Arg Glu Ala Phe Arg Val Phe Asp 
            740                 745                 750         


Asn Asp Gly Asn Gly Tyr Ile Gly Ala Ala Glu Leu Arg His Val Met 
        755                 760                 765             


Thr Asp Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile 
    770                 775                 780                 


Arg Val Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe 
785                 790                 795                 800 


Val Gln Met Met Thr Ala Lys Asp Ile Met Ala Gln Val Gln Leu Val 
                805                 810                 815     


Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
            820                 825                 830         


Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg 
        835                 840                 845             


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly 
    850                 855                 860                 


Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser 
865                 870                 875                 880 


Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
                885                 890                 895     


His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly 
            900                 905                 910         


Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
        915                 920                 925             


Val Thr Val Ser Ser 
    930             


