                         SEQUENCE LISTING

<110>  Ichilov Tech Ltd., Tel Aviv Sourasky Medical Center
 
<120>  Fusion Proteins for Treating CNS Diseases

<130>  SMC/021 PCT

<150>  US 63/152345
<151>  2021-02-23

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr Ser Asp Gln Arg Tyr Val 
1               5                   10                  15      


Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr Asp Val Ser Ser Ala Ala 
            20                  25                  30          


Gln Pro Gly Cys Ser Val Leu Asp Glu Ala Phe Gln Arg Tyr Arg Asp 
        35                  40                  45              


Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Tyr Leu Thr Gly Lys 
    50                  55                  60                  


Arg His Thr Leu Glu Lys Asn Val Leu Val Val Ser Val Val Thr Pro 
65                  70                  75                  80  


Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser Val Glu Asn Tyr Thr Leu 
                85                  90                  95      


Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu Ser Glu Thr Val Trp Gly 
            100                 105                 110         


Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser Ala 
        115                 120                 125             


Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu Ile Glu Asp Phe Pro Arg 
    130                 135                 140                 


Phe Pro His Arg Gly Leu Leu Leu Asp Thr Ser Arg His Tyr Leu Pro 
145                 150                 155                 160 


Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys Leu 
                165                 170                 175     


Asn Val Phe His Trp His Leu Val Asp Asp Pro Ser Phe Pro Tyr Glu 
            180                 185                 190         


Ser Phe Thr Phe Pro Glu Leu Met Arg Lys Gly Ser Tyr Asn Pro Val 
        195                 200                 205             


Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr Ala 
    210                 215                 220                 


Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly His 
225                 230                 235                 240 


Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly Leu Leu Thr Pro Cys Tyr 
                245                 250                 255     


Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly Pro Val Asn Pro Ser Leu 
            260                 265                 270         


Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe Phe Leu Glu Val Ser Ser 
        275                 280                 285             


Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp Phe 
    290                 295                 300                 


Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln Asp Phe Met Arg Lys Lys 
305                 310                 315                 320 


Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln Thr 
                325                 330                 335     


Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys Gly Tyr Val Val Trp Gln 
            340                 345                 350         


Glu Val Phe Asp Asn Lys Val Lys Ile Gln Pro Asp Thr Ile Ile Gln 
        355                 360                 365             


Val Trp Arg Glu Asp Ile Pro Val Asn Tyr Met Lys Glu Leu Glu Leu 
    370                 375                 380                 


Val Thr Lys Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr Leu 
385                 390                 395                 400 


Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys Asp Phe Tyr Ile Val Glu 
                405                 410                 415     


Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln Lys Ala Leu Val Ile Gly 
            420                 425                 430         


Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Asn Thr Asn Leu Val 
        435                 440                 445             


Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp Ser 
    450                 455                 460                 


Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala Tyr Glu Arg Leu Ser His 
465                 470                 475                 480 


Phe Arg Cys Glu Leu Leu Arg Arg Gly Val Gln Ala Gln Pro Leu Asn 
                485                 490                 495     


Val Gly Phe Cys Glu Gln Glu Phe Glu Gln Thr 
            500                 505         


<210>  2
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys 
        355                 360                 365             


Gly Tyr Val Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln 
    370                 375                 380                 


Pro Asp Thr Ile Ile Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr 
385                 390                 395                 400 


Met Lys Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu 
                405                 410                 415     


Ser Ala Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys 
            420                 425                 430         


Asp Phe Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln 
        435                 440                 445             


Lys Ala Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val 
    450                 455                 460                 


Asp Asn Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val 
465                 470                 475                 480 


Ala Glu Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala 
                485                 490                 495     


Tyr Glu Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val 
            500                 505                 510         


Gln Ala Gln Pro Leu Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln 
        515                 520                 525             


Thr 
    


<210>  3
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Leu Glu Lys Asn Val Leu Val Val Ser Val Val Thr Pro Gly Cys 
1               5                   10                  15      


Asn Gln Leu Pro Thr Leu Glu Ser Val Glu Asn Tyr Thr Leu Thr Ile 
            20                  25                  30          


Asn Asp Asp Gln Cys Leu Leu Leu Ser Glu Thr Val Trp Gly Ala Leu 
        35                  40                  45              


Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser Ala Glu Gly 
    50                  55                  60                  


Thr Phe Phe Ile Asn Lys Thr Glu Ile Glu Asp Phe Pro Arg Phe Pro 
65                  70                  75                  80  


His Arg Gly Leu Leu Leu Asp Thr Ser Arg His Tyr Leu Pro Leu Ser 
                85                  90                  95      


Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys Leu Asn Val 
            100                 105                 110         


Phe His Trp His Leu Val Asp Asp Pro Ser Phe Pro Tyr Glu Ser Phe 
        115                 120                 125             


Thr Phe Pro Glu Leu Met Arg Lys Gly Ser Tyr Asn Pro Val Thr His 
    130                 135                 140                 


Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr Ala Arg Leu 
145                 150                 155                 160 


Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly His Thr Leu 
                165                 170                 175     


Ser Trp Gly Pro Gly Ile Pro Gly Leu Leu Thr Pro Cys Tyr Ser Gly 
            180                 185                 190         


Ser Glu Pro Ser Gly Thr Phe Gly Pro Val Asn Pro Ser Leu Asn Asn 
        195                 200                 205             


Thr Tyr Glu Phe Met Ser Thr Phe Phe Leu Glu Val Ser Ser Val Phe 
    210                 215                 220                 


Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp Phe Thr Cys 
225                 230                 235                 240 


Trp Lys Ser Asn Pro Glu Ile Gln Asp Phe Met Arg Lys Lys Gly Phe 
                245                 250                 255     


Gly Glu Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln Thr Leu Leu 
            260                 265                 270         


Asp Ile Val Ser Ser Tyr Gly Lys Gly Tyr Val Val Trp Gln Glu Val 
        275                 280                 285             


Phe Asp Asn Lys Val Lys Ile Gln Pro Asp Thr Ile Ile Gln Val Trp 
    290                 295                 300                 


Arg Glu Asp Ile Pro Val Asn Tyr Met Lys Glu Leu Glu Leu Val Thr 
305                 310                 315                 320 


Lys Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr Leu Asn Arg 
                325                 330                 335     


Ile Ser Tyr Gly Pro Asp Trp Lys Asp Phe Tyr Ile Val Glu Pro Leu 
            340                 345                 350         


Ala Phe Glu Gly Thr Pro Glu Gln Lys Ala Leu Val Ile Gly Gly Glu 
        355                 360                 365             


Ala Cys Met Trp Gly Glu Tyr Val Asp Asn Thr Asn Leu Val Pro Arg 
    370                 375                 380                 


Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp Ser Asn Lys 
385                 390                 395                 400 


Leu Thr Ser Asp Leu Thr Phe Ala Tyr Glu Arg Leu Ser His Phe Arg 
                405                 410                 415     


Cys Glu Leu Leu Arg Arg Gly Val Gln Ala Gln Pro Leu Asn Val Gly 
            420                 425                 430         


Phe Cys Glu Gln Glu Phe Glu Gln Thr 
        435                 440     


<210>  4
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp 
            180                 185                 190     


<210>  5
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu Ser Ala 
1               5                   10                  15      


Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys Asp Phe 
            20                  25                  30          


Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln Lys Ala 
        35                  40                  45              


Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Asn 
    50                  55                  60                  


Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu 
65                  70                  75                  80  


Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala Tyr Glu 
                85                  90                  95      


Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val Gln Ala 
            100                 105                 110         


Gln Pro Leu Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln Thr 
        115                 120                 125         


<210>  6
<211>  11
<212>  PRT
<213>  Synthetic peptide

<400>  6

His Ala Ile Tyr Pro Arg His Gly Ser Ser Arg 
1               5                   10      


<210>  7
<211>  12
<212>  PRT
<213>  Synthetic peptide

<400>  7

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  8
<211>  51
<212>  PRT
<213>  Synthetic peptide

<400>  8

Gly Ser Arg Glu Gly Cys Ala Ser Arg Cys Thr Lys Tyr Asn Ala Glu 
1               5                   10                  15      


Leu Glu Lys Cys Glu Ala Arg Val Ser Ser Met Ser Asn Thr Glu Glu 
            20                  25                  30          


Thr Cys Val Gln Glu Leu Phe Asp Leu Leu His Cys Val Asp His Cys 
        35                  40                  45              


Val Ser Gln 
    50      


<210>  9
<211>  51
<212>  PRT
<213>  Synthetic peptide

<400>  9

Gly Ser Arg Glu Gly Cys Ala Ser Arg Cys Thr Lys Tyr Asn Ala Glu 
1               5                   10                  15      


Leu Glu Lys Cys Glu Ala Arg Val Met Ser Met Ser Asn Thr Glu Glu 
            20                  25                  30          


Asp Cys Glu Gln Glu Leu Glu Asp Leu Leu His Cys Leu Asp His Cys 
        35                  40                  45              


His Ser Gln 
    50      


<210>  10
<211>  51
<212>  PRT
<213>  Syntheitc peptide

<400>  10

Gly Ser Arg Glu Gly Cys Ala Ser Arg Cys Met Lys Tyr Asn Asp Glu 
1               5                   10                  15      


Leu Glu Lys Cys Glu Ala Arg Met Met Ser Met Ser Asn Thr Glu Glu 
            20                  25                  30          


Asp Cys Glu Gln Glu Leu Glu Asp Leu Leu Tyr Cys Leu Asp His Cys 
        35                  40                  45              


His Ser Gln 
    50      


<210>  11
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  12
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  13
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu 
        35                  40                  45              


Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu 
    50                  55                  60                  


Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln 
65                  70                  75                  80  


Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu 
                85                  90                  95      


Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 
            100                 105                 110         


Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 
        115                 120                 125             


Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 
    130                 135                 140                 


Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 
145                 150                 155                 160 


Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln 
                165                 170                 175     


Pro 
    


<210>  14
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 
        195                 200                 


<210>  15
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu 
        35                  40                  45              


Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu 
    50                  55                  60                  


Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln 
65                  70                  75                  80  


Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu 
                85                  90                  95      


Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 
            100                 105                 110         


Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 
        115                 120                 125             


Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 
    130                 135                 140                 


Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 
145                 150                 155                 160 


Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 
                165                 170                 


<210>  16
<211>  41
<212>  PRT
<213>  Synthetic peptide

<400>  16

Gly Ser Gly Ser Asp Arg Val Tyr Ile His Pro Phe His Leu Gly Ser 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40      


<210>  17
<211>  41
<212>  PRT
<213>  Synthetic peptide

<400>  17

Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Asp Arg 
1               5                   10                  15      


Val Tyr Ile His Pro Phe His Leu Gly Gly Ser Gly Ser Gly Gly Ser 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        35                  40      


<210>  18
<211>  764
<212>  PRT
<213>  Synthetic protein

<400>  18

Met Gly Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
1               5                   10                  15      


Pro Gly Ser Thr Gly Asp His Ala Ile Tyr Pro Arg His Gly Ser Ser 
            20                  25                  30          


Arg Gly Ser Gly Ser Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 
        35                  40                  45              


Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly 
    50                  55                  60                  


Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys 
65                  70                  75                  80  


His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp 
                85                  90                  95      


Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys 
            100                 105                 110         


Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln 
        115                 120                 125             


Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu 
    130                 135                 140                 


Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu 
145                 150                 155                 160 


Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro 
                165                 170                 175     


Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 
            180                 185                 190         


Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 
        195                 200                 205             


Leu Ala Gln Pro Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly 
    210                 215                 220                 


Ser Gly Gly Ser Asp Arg Val Tyr Ile His Pro Phe His Leu Gly Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Glu 
                245                 250                 255     


Leu Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr Ser Asp Gln Arg Tyr 
            260                 265                 270         


Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr Asp Val Ser Ser Ala 
        275                 280                 285             


Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala Phe Gln Arg Tyr Arg 
    290                 295                 300                 


Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Tyr Leu Thr Gly 
305                 310                 315                 320 


Lys Arg His Thr Leu Glu Lys Asn Val Leu Val Val Ser Val Val Thr 
                325                 330                 335     


Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser Val Glu Asn Tyr Thr 
            340                 345                 350         


Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu Ser Glu Thr Val Trp 
        355                 360                 365             


Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser 
    370                 375                 380                 


Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu Ile Glu Asp Phe Pro 
385                 390                 395                 400 


Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr Ser Arg His Tyr Leu 
                405                 410                 415     


Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys 
            420                 425                 430         


Leu Asn Val Phe His Trp His Leu Val Asp Asp Pro Ser Phe Pro Tyr 
        435                 440                 445             


Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys Gly Ser Tyr Asn Pro 
    450                 455                 460                 


Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr 
465                 470                 475                 480 


Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly 
                485                 490                 495     


His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly Leu Leu Thr Pro Cys 
            500                 505                 510         


Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly Pro Val Asn Pro Ser 
        515                 520                 525             


Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe Phe Leu Glu Val Ser 
    530                 535                 540                 


Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp 
545                 550                 555                 560 


Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln Asp Phe Met Arg Lys 
                565                 570                 575     


Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln 
            580                 585                 590         


Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys Gly Tyr Val Val Trp 
        595                 600                 605             


Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln Pro Asp Thr Ile Ile 
    610                 615                 620                 


Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr Met Lys Glu Leu Glu 
625                 630                 635                 640 


Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr 
                645                 650                 655     


Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys Asp Phe Tyr Ile Val 
            660                 665                 670         


Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln Lys Ala Leu Val Ile 
        675                 680                 685             


Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Asn Thr Asn Leu 
    690                 695                 700                 


Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp 
705                 710                 715                 720 


Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala Tyr Glu Arg Leu Ser 
                725                 730                 735     


His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val Gln Ala Gln Pro Leu 
            740                 745                 750         


Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln Thr 
        755                 760                 


<210>  19
<211>  178
<212>  PRT
<213>  Mus musculus

<400>  19

Val Pro Leu Val Thr Val Ser Ala Leu Pro Pro Ser Leu Pro Leu Pro 
1               5                   10                  15      


Arg Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Ala 
            20                  25                  30          


Ser Gly Ser Val Leu Leu Glu Gln Leu Cys Ala Thr Tyr Lys Leu Cys 
        35                  40                  45              


His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Lys 
    50                  55                  60                  


Ala Ser Leu Ser Gly Cys Ser Ser Gln Ala Leu Gln Gln Thr Gln Cys 
65                  70                  75                  80  


Leu Ser Gln Leu His Ser Gly Leu Cys Leu Tyr Gln Gly Leu Leu Gln 
                85                  90                  95      


Ala Leu Ser Gly Ile Ser Pro Ala Leu Ala Pro Thr Leu Asp Leu Leu 
            100                 105                 110         


Gln Leu Asp Val Ala Asn Phe Ala Thr Thr Ile Trp Gln Gln Met Glu 
        115                 120                 125             


Asn Leu Gly Val Ala Pro Thr Val Gln Pro Thr Gln Ser Ala Met Pro 
    130                 135                 140                 


Ala Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Ala Ile 
145                 150                 155                 160 


Ser Tyr Leu Gln Gly Phe Leu Glu Thr Ala Arg Leu Ala Leu His His 
                165                 170                 175     


Leu Ala 
        


<210>  20
<211>  9
<212>  PRT
<213>  Synthetic peptide

<400>  20

His Ala Ile Tyr Pro Arg His Gly Ser 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Synthetic peptide

<400>  21

Asp Arg Val Tyr Ile His Pro Phe His Leu 
1               5                   10  


<210>  22
<211>  65
<212>  PRT
<213>  Synthetic peptide

<400>  22

Ala Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Ala Lys Glu Ala Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu 
        35                  40                  45              


Ala Ala Ala Ala Lys Ala Asp Arg Val Tyr Ile His Pro Phe His Leu 
    50                  55                  60                  


Gly 
65  


<210>  23
<211>  68
<212>  PRT
<213>  Synthetic peptide

<400>  23

Ala Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Ala Lys Glu Ala Ala Ala Ala Lys Ala Leu Glu Asp Arg Val Tyr 
            20                  25                  30          


Ile His Pro Phe His Leu Gly Ala Glu Ala Ala Ala Ala Lys Glu Ala 
        35                  40                  45              


Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys 
    50                  55                  60                  


Ala Cys Cys Cys 
65              


<210>  24
<211>  506
<212>  PRT
<213>  Mus musculus

<400>  24

Leu Trp Pro Trp Pro Gln Tyr Ile Gln Thr Tyr His Arg Arg Tyr Thr 
1               5                   10                  15      


Leu Tyr Pro Asn Asn Phe Gln Phe Arg Tyr His Val Ser Ser Ala Ala 
            20                  25                  30          


Gln Ala Gly Cys Val Val Leu Asp Glu Ala Phe Arg Arg Tyr Arg Asn 
        35                  40                  45              


Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Ser Phe Ser Asn Lys 
    50                  55                  60                  


Gln Gln Thr Leu Gly Lys Asn Ile Leu Val Val Ser Val Val Thr Ala 
65                  70                  75                  80  


Glu Cys Asn Glu Phe Pro Asn Leu Glu Ser Val Glu Asn Tyr Thr Leu 
                85                  90                  95      


Thr Ile Asn Asp Asp Gln Cys Leu Leu Ala Ser Glu Thr Val Trp Gly 
            100                 105                 110         


Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser Ala 
        115                 120                 125             


Glu Gly Thr Phe Phe Ile Asn Lys Thr Lys Ile Lys Asp Phe Pro Arg 
    130                 135                 140                 


Phe Pro His Arg Gly Val Leu Leu Asp Thr Ser Arg His Tyr Leu Pro 
145                 150                 155                 160 


Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys Phe 
                165                 170                 175     


Asn Val Phe His Trp His Leu Val Asp Asp Ser Ser Phe Pro Tyr Glu 
            180                 185                 190         


Ser Phe Thr Phe Pro Glu Leu Thr Arg Lys Gly Ser Phe Asn Pro Val 
        195                 200                 205             


Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr Ala 
    210                 215                 220                 


Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly His 
225                 230                 235                 240 


Thr Leu Ser Trp Gly Pro Gly Ala Pro Gly Leu Leu Thr Pro Cys Tyr 
                245                 250                 255     


Ser Gly Ser His Leu Ser Gly Thr Phe Gly Pro Val Asn Pro Ser Leu 
            260                 265                 270         


Asn Ser Thr Tyr Asp Phe Met Ser Thr Leu Phe Leu Glu Ile Ser Ser 
        275                 280                 285             


Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp Phe 
    290                 295                 300                 


Thr Cys Trp Lys Ser Asn Pro Asn Ile Gln Ala Phe Met Lys Lys Lys 
305                 310                 315                 320 


Gly Phe Thr Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln Thr Leu 
                325                 330                 335     


Leu Asp Ile Val Ser Asp Tyr Asp Lys Gly Tyr Val Val Trp Gln Glu 
            340                 345                 350         


Val Phe Asp Asn Lys Val Lys Val Arg Pro Asp Thr Ile Ile Gln Val 
        355                 360                 365             


Trp Arg Glu Glu Met Pro Val Glu Tyr Met Leu Glu Met Gln Asp Ile 
    370                 375                 380                 


Thr Arg Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr Leu Asn 
385                 390                 395                 400 


Arg Val Lys Tyr Gly Pro Asp Trp Lys Asp Met Tyr Lys Val Glu Pro 
                405                 410                 415     


Leu Ala Phe His Gly Thr Pro Glu Gln Lys Ala Leu Val Ile Gly Gly 
            420                 425                 430         


Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Ser Thr Asn Leu Val Pro 
        435                 440                 445             


Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp Ser Ser 
    450                 455                 460                 


Asn Leu Thr Thr Asn Ile Asp Phe Ala Phe Lys Arg Leu Ser His Phe 
465                 470                 475                 480 


Arg Cys Glu Leu Val Arg Arg Gly Ile Gln Ala Gln Pro Ile Ser Val 
                485                 490                 495     


Gly Tyr Cys Glu Gln Glu Phe Glu Gln Thr 
            500                 505     


<210>  25
<211>  20
<212>  PRT
<213>  Synthetic peptide

<400>  25

Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly 
1               5                   10                  15      


Ser Thr Gly Asp 
            20  


<210>  26
<211>  15
<212>  PRT
<213>  Synthetic peptide

<400>  26

Gly Thr Glu Asn Leu Tyr Phe Gln Gly His His His His His His 
1               5                   10                  15  


<210>  27
<211>  750
<212>  PRT
<213>  Synthetic protein

<400>  27

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Pro Leu Val Thr Val Ser Ala Leu Pro Pro 
            20                  25                  30          


Ser Leu Pro Leu Pro Arg Ser Phe Leu Leu Lys Ser Leu Glu Gln Val 
        35                  40                  45              


Arg Lys Ile Gln Ala Ser Gly Ser Val Leu Leu Glu Gln Leu Cys Ala 
    50                  55                  60                  


Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser 
65                  70                  75                  80  


Leu Gly Ile Pro Lys Ala Ser Leu Ser Gly Cys Ser Ser Gln Ala Leu 
                85                  90                  95      


Gln Gln Thr Gln Cys Leu Ser Gln Leu His Ser Gly Leu Cys Leu Tyr 
            100                 105                 110         


Gln Gly Leu Leu Gln Ala Leu Ser Gly Ile Ser Pro Ala Leu Ala Pro 
        115                 120                 125             


Thr Leu Asp Leu Leu Gln Leu Asp Val Ala Asn Phe Ala Thr Thr Ile 
    130                 135                 140                 


Trp Gln Gln Met Glu Asn Leu Gly Val Ala Pro Thr Val Gln Pro Thr 
145                 150                 155                 160 


Gln Ser Ala Met Pro Ala Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly 
                165                 170                 175     


Gly Val Leu Ala Ile Ser Tyr Leu Gln Gly Phe Leu Glu Thr Ala Arg 
            180                 185                 190         


Leu Ala Leu His His Leu Ala Glu Leu Gly Ser Gly Ser Asp Arg Val 
        195                 200                 205             


Tyr Ile His Pro Phe His Leu Gly Ser Gly Ser Gly Gly Ser Gly Gly 
    210                 215                 220                 


Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Leu Trp Pro Trp Pro Gln Tyr Ile Gln Thr Tyr His 
                245                 250                 255     


Arg Arg Tyr Thr Leu Tyr Pro Asn Asn Phe Gln Phe Arg Tyr His Val 
            260                 265                 270         


Ser Ser Ala Ala Gln Ala Gly Cys Val Val Leu Asp Glu Ala Phe Arg 
        275                 280                 285             


Arg Tyr Arg Asn Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Ser 
    290                 295                 300                 


Phe Ser Asn Lys Gln Gln Thr Leu Gly Lys Asn Ile Leu Val Val Ser 
305                 310                 315                 320 


Val Val Thr Ala Glu Cys Asn Glu Phe Pro Asn Leu Glu Ser Val Glu 
                325                 330                 335     


Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Ala Ser Glu 
            340                 345                 350         


Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val 
        355                 360                 365             


Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Lys Ile Lys 
    370                 375                 380                 


Asp Phe Pro Arg Phe Pro His Arg Gly Val Leu Leu Asp Thr Ser Arg 
385                 390                 395                 400 


His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala 
                405                 410                 415     


Tyr Asn Lys Phe Asn Val Phe His Trp His Leu Val Asp Asp Ser Ser 
            420                 425                 430         


Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Thr Arg Lys Gly Ser 
        435                 440                 445             


Phe Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val 
    450                 455                 460                 


Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp 
465                 470                 475                 480 


Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ala Pro Gly Leu Leu 
                485                 490                 495     


Thr Pro Cys Tyr Ser Gly Ser His Leu Ser Gly Thr Phe Gly Pro Val 
            500                 505                 510         


Asn Pro Ser Leu Asn Ser Thr Tyr Asp Phe Met Ser Thr Leu Phe Leu 
        515                 520                 525             


Glu Ile Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp 
    530                 535                 540                 


Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Asn Ile Gln Ala Phe 
545                 550                 555                 560 


Met Lys Lys Lys Gly Phe Thr Asp Phe Lys Gln Leu Glu Ser Phe Tyr 
                565                 570                 575     


Ile Gln Thr Leu Leu Asp Ile Val Ser Asp Tyr Asp Lys Gly Tyr Val 
            580                 585                 590         


Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Val Arg Pro Asp Thr 
        595                 600                 605             


Ile Ile Gln Val Trp Arg Glu Glu Met Pro Val Glu Tyr Met Leu Glu 
    610                 615                 620                 


Met Gln Asp Ile Thr Arg Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro 
625                 630                 635                 640 


Trp Tyr Leu Asn Arg Val Lys Tyr Gly Pro Asp Trp Lys Asp Met Tyr 
                645                 650                 655     


Lys Val Glu Pro Leu Ala Phe His Gly Thr Pro Glu Gln Lys Ala Leu 
            660                 665                 670         


Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Ser Thr 
        675                 680                 685             


Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg 
    690                 695                 700                 


Leu Trp Ser Ser Asn Leu Thr Thr Asn Ile Asp Phe Ala Phe Lys Arg 
705                 710                 715                 720 


Leu Ser His Phe Arg Cys Glu Leu Val Arg Arg Gly Ile Gln Ala Gln 
                725                 730                 735     


Pro Ile Ser Val Gly Tyr Cys Glu Gln Glu Phe Glu Gln Thr 
            740                 745                 750 


<210>  28
<211>  539
<212>  PRT
<213>  Synthetic protein

<400>  28

Met Gly Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
1               5                   10                  15      


Pro Gly Ser Thr Gly Asp His Ala Ile Tyr Pro Arg His Gly Ser Ser 
            20                  25                  30          


Arg Leu Trp Pro Trp Pro Gln Tyr Ile Gln Thr Tyr His Arg Arg Tyr 
        35                  40                  45              


Thr Leu Tyr Pro Asn Asn Phe Gln Phe Arg Tyr His Val Ser Ser Ala 
    50                  55                  60                  


Ala Gln Ala Gly Cys Val Val Leu Asp Glu Ala Phe Arg Arg Tyr Arg 
65                  70                  75                  80  


Asn Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Ser Phe Ser Asn 
                85                  90                  95      


Lys Gln Gln Thr Leu Gly Lys Asn Ile Leu Val Val Ser Val Val Thr 
            100                 105                 110         


Ala Glu Cys Asn Glu Phe Pro Asn Leu Glu Ser Val Glu Asn Tyr Thr 
        115                 120                 125             


Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Ala Ser Glu Thr Val Trp 
    130                 135                 140                 


Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser 
145                 150                 155                 160 


Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Lys Ile Lys Asp Phe Pro 
                165                 170                 175     


Arg Phe Pro His Arg Gly Val Leu Leu Asp Thr Ser Arg His Tyr Leu 
            180                 185                 190         


Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys 
        195                 200                 205             


Phe Asn Val Phe His Trp His Leu Val Asp Asp Ser Ser Phe Pro Tyr 
    210                 215                 220                 


Glu Ser Phe Thr Phe Pro Glu Leu Thr Arg Lys Gly Ser Phe Asn Pro 
225                 230                 235                 240 


Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr 
                245                 250                 255     


Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly 
            260                 265                 270         


His Thr Leu Ser Trp Gly Pro Gly Ala Pro Gly Leu Leu Thr Pro Cys 
        275                 280                 285             


Tyr Ser Gly Ser His Leu Ser Gly Thr Phe Gly Pro Val Asn Pro Ser 
    290                 295                 300                 


Leu Asn Ser Thr Tyr Asp Phe Met Ser Thr Leu Phe Leu Glu Ile Ser 
305                 310                 315                 320 


Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp 
                325                 330                 335     


Phe Thr Cys Trp Lys Ser Asn Pro Asn Ile Gln Ala Phe Met Lys Lys 
            340                 345                 350         


Lys Gly Phe Thr Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln Thr 
        355                 360                 365             


Leu Leu Asp Ile Val Ser Asp Tyr Asp Lys Gly Tyr Val Val Trp Gln 
    370                 375                 380                 


Glu Val Phe Asp Asn Lys Val Lys Val Arg Pro Asp Thr Ile Ile Gln 
385                 390                 395                 400 


Val Trp Arg Glu Glu Met Pro Val Glu Tyr Met Leu Glu Met Gln Asp 
                405                 410                 415     


Ile Thr Arg Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr Leu 
            420                 425                 430         


Asn Arg Val Lys Tyr Gly Pro Asp Trp Lys Asp Met Tyr Lys Val Glu 
        435                 440                 445             


Pro Leu Ala Phe His Gly Thr Pro Glu Gln Lys Ala Leu Val Ile Gly 
    450                 455                 460                 


Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Ser Thr Asn Leu Val 
465                 470                 475                 480 


Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp Ser 
                485                 490                 495     


Ser Asn Leu Thr Thr Asn Ile Asp Phe Ala Phe Lys Arg Leu Ser His 
            500                 505                 510         


Phe Arg Cys Glu Leu Val Arg Arg Gly Ile Gln Ala Gln Pro Ile Ser 
        515                 520                 525             


Val Gly Tyr Cys Glu Gln Glu Phe Glu Gln Thr 
    530                 535                 


<210>  29
<211>  764
<212>  PRT
<213>  Synthetic protein

<400>  29

Met Gly Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
1               5                   10                  15      


Pro Gly Ser Thr Gly Asp His Ala Ile Tyr Pro Arg His Gly Ser Gly 
            20                  25                  30          


Ser Gly Ser Val Pro Leu Val Thr Val Ser Ala Leu Pro Pro Ser Leu 
        35                  40                  45              


Pro Leu Pro Arg Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys 
    50                  55                  60                  


Ile Gln Ala Ser Gly Ser Val Leu Leu Glu Gln Leu Cys Ala Thr Tyr 
65                  70                  75                  80  


Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 
                85                  90                  95      


Ile Pro Lys Ala Ser Leu Ser Gly Cys Ser Ser Gln Ala Leu Gln Gln 
            100                 105                 110         


Thr Gln Cys Leu Ser Gln Leu His Ser Gly Leu Cys Leu Tyr Gln Gly 
        115                 120                 125             


Leu Leu Gln Ala Leu Ser Gly Ile Ser Pro Ala Leu Ala Pro Thr Leu 
    130                 135                 140                 


Asp Leu Leu Gln Leu Asp Val Ala Asn Phe Ala Thr Thr Ile Trp Gln 
145                 150                 155                 160 


Gln Met Glu Asn Leu Gly Val Ala Pro Thr Val Gln Pro Thr Gln Ser 
                165                 170                 175     


Ala Met Pro Ala Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val 
            180                 185                 190         


Leu Ala Ile Ser Tyr Leu Gln Gly Phe Leu Glu Thr Ala Arg Leu Ala 
        195                 200                 205             


Leu His His Leu Ala Glu Leu Gly Ser Gly Ser Asp Arg Val Tyr Ile 
    210                 215                 220                 


His Pro Phe His Leu Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                245                 250                 255     


Ser Arg Leu Trp Pro Trp Pro Gln Tyr Ile Gln Thr Tyr His Arg Arg 
            260                 265                 270         


Tyr Thr Leu Tyr Pro Asn Asn Phe Gln Phe Arg Tyr His Val Ser Ser 
        275                 280                 285             


Ala Ala Gln Ala Gly Cys Val Val Leu Asp Glu Ala Phe Arg Arg Tyr 
    290                 295                 300                 


Arg Asn Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Ser Phe Ser 
305                 310                 315                 320 


Asn Lys Gln Gln Thr Leu Gly Lys Asn Ile Leu Val Val Ser Val Val 
                325                 330                 335     


Thr Ala Glu Cys Asn Glu Phe Pro Asn Leu Glu Ser Val Glu Asn Tyr 
            340                 345                 350         


Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Ala Ser Glu Thr Val 
        355                 360                 365             


Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys 
    370                 375                 380                 


Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Lys Ile Lys Asp Phe 
385                 390                 395                 400 


Pro Arg Phe Pro His Arg Gly Val Leu Leu Asp Thr Ser Arg His Tyr 
                405                 410                 415     


Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn 
            420                 425                 430         


Lys Phe Asn Val Phe His Trp His Leu Val Asp Asp Ser Ser Phe Pro 
        435                 440                 445             


Tyr Glu Ser Phe Thr Phe Pro Glu Leu Thr Arg Lys Gly Ser Phe Asn 
    450                 455                 460                 


Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu 
465                 470                 475                 480 


Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro 
                485                 490                 495     


Gly His Thr Leu Ser Trp Gly Pro Gly Ala Pro Gly Leu Leu Thr Pro 
            500                 505                 510         


Cys Tyr Ser Gly Ser His Leu Ser Gly Thr Phe Gly Pro Val Asn Pro 
        515                 520                 525             


Ser Leu Asn Ser Thr Tyr Asp Phe Met Ser Thr Leu Phe Leu Glu Ile 
    530                 535                 540                 


Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val 
545                 550                 555                 560 


Asp Phe Thr Cys Trp Lys Ser Asn Pro Asn Ile Gln Ala Phe Met Lys 
                565                 570                 575     


Lys Lys Gly Phe Thr Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln 
            580                 585                 590         


Thr Leu Leu Asp Ile Val Ser Asp Tyr Asp Lys Gly Tyr Val Val Trp 
        595                 600                 605             


Gln Glu Val Phe Asp Asn Lys Val Lys Val Arg Pro Asp Thr Ile Ile 
    610                 615                 620                 


Gln Val Trp Arg Glu Glu Met Pro Val Glu Tyr Met Leu Glu Met Gln 
625                 630                 635                 640 


Asp Ile Thr Arg Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr 
                645                 650                 655     


Leu Asn Arg Val Lys Tyr Gly Pro Asp Trp Lys Asp Met Tyr Lys Val 
            660                 665                 670         


Glu Pro Leu Ala Phe His Gly Thr Pro Glu Gln Lys Ala Leu Val Ile 
        675                 680                 685             


Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Ser Thr Asn Leu 
    690                 695                 700                 


Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp 
705                 710                 715                 720 


Ser Ser Asn Leu Thr Thr Asn Ile Asp Phe Ala Phe Lys Arg Leu Ser 
                725                 730                 735     


His Phe Arg Cys Glu Leu Val Arg Arg Gly Ile Gln Ala Gln Pro Ile 
            740                 745                 750         


Ser Val Gly Tyr Cys Glu Gln Glu Phe Glu Gln Thr 
        755                 760                 


<210>  30
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  30

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  31
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Pro Met Lys Glu Val Asn Val His Gly Gln Gly Asn Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Arg 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr Phe Glu 
        35                  40                  45              


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
    50                  55                  60                  


Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
65                  70                  75                  80  


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
                85                  90                  95      


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
            100                 105                 110         


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
        115                 120                 125             


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
    130                 135                 140                 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
145                 150                 155                 160 


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
                165                 170                 175     


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
            180                 185                 190         


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
        195                 200                 205             


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
    210                 215                 220                 


Leu Thr Ile Lys Arg Gly Arg 
225                 230     


<210>  32
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  32

Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His Val 
        35                  40                  45              


Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu Glu 
    50                  55                  60                  


Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser Ser 
65                  70                  75                  80  


Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys 
                85                  90                  95      


Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His Ser 
            100                 105                 110         


Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser Glu 
        115                 120                 125             


Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly Gly 
    130                 135                 140                 


Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu Lys 
145                 150                 155                 160 


Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu 
                165                 170                 175     


Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg Thr 
            180                 185                 190         


Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg Ile 
        195                 200                 205             


Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu Thr 
    210                 215                 220                 


Ile Lys Arg Gly Arg 
225                 


<210>  33
<211>  4
<212>  PRT
<213>  Synthetic peptide

<400>  33

Arg Val Arg Arg 
1               


<210>  34
<211>  5
<212>  PRT
<213>  Synthetic peptide

<400>  34

Asn Asn Asn Asn Lys 
1               5   


<210>  35
<211>  14
<212>  PRT
<213>  Synthetic peptide

<400>  35

Gly Thr Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10                  


<210>  36
<211>  13
<212>  PRT
<213>  Synthetic peptide

<400>  36

Gly Ser Gly Ser Gly Ser His Ala Ile Tyr Pro Arg His 
1               5                   10              


<210>  37
<211>  7
<212>  PRT
<213>  Synthetic peptide

<400>  37

His Ala Ile Tyr Pro Arg His 
1               5           


<210>  38
<211>  327
<212>  PRT
<213>  Synthetic protein

<400>  38

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg Gly Thr Gly Ser Ala Gly Ser Ala Ala 
        115                 120                 125             


Gly Ser Gly Glu Phe Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 
    130                 135                 140                 


Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly 
145                 150                 155                 160 


Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys 
                165                 170                 175     


His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp 
            180                 185                 190         


Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys 
        195                 200                 205             


Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln 
    210                 215                 220                 


Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu 
225                 230                 235                 240 


Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu 
                245                 250                 255     


Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro 
            260                 265                 270         


Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 
        275                 280                 285             


Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 
    290                 295                 300                 


Leu Ala Gln Pro Gly Ser Gly Ser His Ala Ile Tyr Pro Arg His Gly 
305                 310                 315                 320 


Ser His His His His His His 
                325         


<210>  39
<211>  18
<212>  PRT
<213>  Synthetic peptide

<400>  39

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala 
        


<210>  40
<211>  2295
<212>  DNA
<213>  Synthetic sequence

<400>  40
atgggggaga ccgacaccct gctgctgtgg gtgctgctgc tgtgggtgcc cggcagcacc       60

ggcgacgcca cccctctggg ccctgcctcc agcctgcccc agtccttcct gctgaagtgc      120

ctggaacagg tgcgcaagat ccagggcgac ggcgctgccc tgcaggaaaa gctctgcgcc      180

acctacaagc tgtgccaccc cgaggaactg gtgctgctgg gacacagcct gggaatccct      240

tgggcccctc tgtcctcctg ccctagccag gctctgcagc tggccggatg cctgtcccag      300

ctgcactccg gcctgttcct ctaccaggga ctgctgcagg ctctcgaagg catctccccc      360

gagctgggcc ctaccctgga cacactgcag ctggacgtgg ccgacttcgc caccaccatc      420

tggcagcaga tggaagaact gggcatggcc ccagctctgc agcctaccca gggcgccatg      480

cctgccttcg cctccgcctt ccagagaagg gctggaggag tgctggtggc ctcccacctg      540

cagtcattcc tcgaagtgtc ctaccgcgtg ctgaggcacc tggcccagcc cggatccggc      600

agcggcagcg acagggtgta catccacccc tttcacctgg gcagcggaag cggaggaagc      660

ggaggaagcg gaggaagcgg cagcggagga agcggaagcg gaggaagcgg aggcagcggc      720

tctagactgt ggccttggcc ccagaacttc cagacctccg accagcgcta cgtgctgtac      780

cccaacaact tccagttcca gtacgacgtg tcctccgccg ctcagcctgg atgctccgtg      840

ctggacgagg ccttccagcg ctacagggac ctgctgttcg gctccggctc ctggcccagg      900

ccctacctga ccggcaagcg ccacaccctg gaaaagaacg tgctggtggt gtccgtggtg      960

acccccggct gcaaccagct gcccaccctg gaatccgtgg agaactacac cctgaccatc     1020

aacgacgatc agtgcctgct gctgtccgag actgtgtggg gagccctgcg cggcctggaa     1080

accttctccc agctggtgtg gaagtccgcc gagggcacct tcttcatcaa caagaccgag     1140

atcgaggact tcccccgctt ccctcaccgc ggactgctgc tggacacctc ccgccactac     1200

ctgcccctgt cctccatcct ggacaccctg gacgtgatgg cctacaacaa gctgaacgtg     1260

ttccactggc acctggtgga cgaccccagc ttcccctacg agtccttcac cttccccgag     1320

ctgatgcgca agggctctta caaccccgtg acccacatct acaccgccca ggacgtgaag     1380

gaagtgatcg agtacgcccg cctgaggggc atcagggtgc tggccgagtt cgacaccccc     1440

ggacacaccc tgtcttgggg acccggcatc cccggtctgc tgaccccctg ctactccggc     1500

tctgagccct ccggcacctt cggccccgtg aacccctccc tgaacaacac ctacgagttt     1560

atgtctacat tcttcctgga agtgtcatcc gtgttccccg acttctacct gcacctgggc     1620

ggcgacgagg tggacttcac ttgctggaag tccaaccccg aaatccagga cttcatgcgc     1680

aagaagggct tcggcgagga cttcaagcag ctggaatcat tctacatcca gaccctgctg     1740

gacatcgtgt cctcttacgg caagggctac gtggtgtggc aggaagtgtt cgacaacaag     1800

gtgaagatcc agcccgacac catcatccag gtgtggcgcg aggacatccc cgtgaactac     1860

atgaaggaac tggaactggt gaccaaggcc ggcttcagag ccctgctgtc cgccccctgg     1920

tatctgaacc gcatctccta cggccccgac tggaaggact tctacatcgt ggagcccctg     1980

gccttcgagg gcacccccga gcagaaggcc ctggtcatcg gcggcgaggc ctgcatgtgg     2040

ggcgagtacg tggacaacac caacctggtg cccaggctgt ggcctagggc tggcgccgtg     2100

gccgagcgcc tgtggtctaa caagctgacc tctgacctga ccttcgccta cgagaggctg     2160

tcccacttcc gctgcgagct gctgagaagg ggcgtgcagg cccagcccct gaacgtgggc     2220

ttctgcgagc aggagttcga gcagactggt accgagaacc tgtacttcca aggccaccac     2280

catcaccatc actaa                                                      2295


<210>  41
<211>  2277
<212>  DNA
<213>  Synthetic sequence

<400>  41
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc       60

gacgtgcccc tggtgaccgt gagcgccctg ccccccagcc tgcccctgcc caggagcttc      120

ctgctgaaga gcctggagca ggtgaggaag atccaggcca gcggcagcgt gctgctggag      180

cagctgtgcg ccacctacaa gctgtgccac cccgaggagc tggtgctgct gggccacagc      240

ctgggcatcc ccaaggccag cctgagcggc tgcagcagcc aggccctgca gcagacccag      300

tgcctgagcc agctgcacag cggcctgtgc ctgtaccagg gcctgctgca ggccctgagc      360

ggcatcagcc ccgccctggc ccccaccctg gacctgctgc agctggacgt ggccaacttc      420

gccaccacca tctggcagca gatggagaac ctgggcgtgg cccccaccgt gcagcccacc      480

cagagcgcca tgcccgcctt caccagcgcc ttccagagga gggccggcgg cgtgctggcc      540

atcagctacc tgcagggctt cctggagacc gccaggctgg ccctgcacca cctggccgag      600

ctcggcagcg gcagcgacag ggtgtacatc cacccctttc acctgggcag cggaagcgga      660

ggaagcggag gaagcggagg aagcggcagc ggaggaagcg gaagcggagg aagcggaggc      720

agcggctcta gactgtggcc ctggccccag tacatccaga cctaccacag gaggtacacc      780

ctgtacccca acaacttcca gttcaggtac cacgtgagca gcgccgccca ggccggctgc      840

gtggtgctgg acgaggcctt caggaggtac aggaacctgc tgttcggcag cggcagctgg      900

cccaggccca gcttcagcaa caagcagcag accctgggca agaacatcct ggtggtgagc      960

gtggtgaccg ccgagtgcaa cgagttcccc aacctggaga gcgtggagaa ctacaccctg     1020

accatcaacg acgaccagtg cctgctggcc agcgagaccg tgtggggcgc cctgaggggc     1080

ctggagacct tcagccagct ggtgtggaag agcgccgagg gcaccttctt catcaacaag     1140

accaagatca aggacttccc caggttcccc cacaggggcg tgctgctgga caccagcagg     1200

cactacctgc ccctgagcag catcctggac accctggacg tgatggccta caacaagttc     1260

aacgtgttcc actggcacct ggtggacgac agcagcttcc cctacgagag cttcaccttc     1320

cccgagctga ccaggaaggg cagcttcaac cccgtgaccc acatctacac cgcccaggac     1380

gtgaaggagg tgatcgagta cgccaggctg aggggcatca gggtgctggc cgagttcgac     1440

acccccggcc acaccctgag ctggggcccc ggcgcccccg gcctgctgac cccctgctac     1500

agcggcagcc acctgagcgg caccttcggc cccgtgaacc ccagcctgaa cagcacctac     1560

gacttcatga gcaccctgtt cctggagatc agcagcgtgt tccccgactt ctacctgcac     1620

ctgggcggcg acgaggtgga cttcacctgc tggaagagca accccaacat ccaggccttc     1680

atgaagaaga agggcttcac cgacttcaag cagctggaga gcttctacat ccagaccctg     1740

ctggacatcg tgagcgacta cgacaagggc tacgtggtgt ggcaggaggt gttcgacaac     1800

aaggtgaagg tgaggcccga caccatcatc caggtgtgga gggaggagat gcccgtggag     1860

tacatgctgg agatgcagga catcaccagg gccggcttca gggccctgct gagcgccccc     1920

tggtacctga acagggtgaa gtacggcccc gactggaagg acatgtacaa ggtggagccc     1980

ctggccttcc acggcacccc cgagcagaag gccctggtga tcggcggcga ggcctgcatg     2040

tggggcgagt acgtggacag caccaacctg gtgcccaggc tgtggcccag ggccggcgcc     2100

gtggccgaga ggctgtggag cagcaacctg accaccaaca tcgacttcgc cttcaagagg     2160

ctgagccact tcaggtgcga gctggtgagg aggggcatcc aggcccagcc catcagcgtg     2220

ggctactgcg agcaggagtt cgagcagacc ggtacccacc accatcacca tcactaa        2277


<210>  42
<211>  1644
<212>  DNA
<213>  Synthetic sequence

<400>  42
atgggggaga ccgacaccct gctgctgtgg gtgctgctgc tgtgggtgcc cggcagcacc       60

ggcgaccacg ccatctaccc caggcacggc agctctagac tgtggccctg gccccagtac      120

atccagacct accacaggag gtacaccctg taccccaaca acttccagtt caggtaccac      180

gtgagcagcg ccgcccaggc cggctgcgtg gtgctggacg aggccttcag gaggtacagg      240

aacctgctgt tcggcagcgg cagctggccc aggcccagct tcagcaacaa gcagcagacc      300

ctgggcaaga acatcctggt ggtgagcgtg gtgaccgccg agtgcaacga gttccccaac      360

ctggagagcg tggagaacta caccctgacc atcaacgacg accagtgcct gctggccagc      420

gagaccgtgt ggggcgccct gaggggcctg gagaccttca gccagctggt gtggaagagc      480

gccgagggca ccttcttcat caacaagacc aagatcaagg acttccccag gttcccccac      540

aggggcgtgc tgctggacac cagcaggcac tacctgcccc tgagcagcat cctggacacc      600

ctggacgtga tggcctacaa caagttcaac gtgttccact ggcacctggt ggacgacagc      660

agcttcccct acgagagctt caccttcccc gagctgacca ggaagggcag cttcaacccc      720

gtgacccaca tctacaccgc ccaggacgtg aaggaggtga tcgagtacgc caggctgagg      780

ggcatcaggg tgctggccga gttcgacacc cccggccaca ccctgagctg gggccccggc      840

gcccccggcc tgctgacccc ctgctacagc ggcagccacc tgagcggcac cttcggcccc      900

gtgaacccca gcctgaacag cacctacgac ttcatgagca ccctgttcct ggagatcagc      960

agcgtgttcc ccgacttcta cctgcacctg ggcggcgacg aggtggactt cacctgctgg     1020

aagagcaacc ccaacatcca ggccttcatg aagaagaagg gcttcaccga cttcaagcag     1080

ctggagagct tctacatcca gaccctgctg gacatcgtga gcgactacga caagggctac     1140

gtggtgtggc aggaggtgtt cgacaacaag gtgaaggtga ggcccgacac catcatccag     1200

gtgtggaggg aggagatgcc cgtggagtac atgctggaga tgcaggacat caccagggcc     1260

ggcttcaggg ccctgctgag cgccccctgg tacctgaaca gggtgaagta cggccccgac     1320

tggaaggaca tgtacaaggt ggagcccctg gccttccacg gcacccccga gcagaaggcc     1380

ctggtgatcg gcggcgaggc ctgcatgtgg ggcgagtacg tggacagcac caacctggtg     1440

cccaggctgt ggcccagggc cggcgccgtg gccgagaggc tgtggagcag caacctgacc     1500

accaacatcg acttcgcctt caagaggctg agccacttca ggtgcgagct ggtgaggagg     1560

ggcatccagg cccagcccat cagcgtgggc tactgcgagc aggagttcga gcagaccggt     1620

acccaccacc atcaccatca ctaa                                            1644


<210>  43
<211>  2319
<212>  DNA
<213>  Synthetic sequence

<400>  43
atgggggaga ccgacaccct gctgctgtgg gtgctgctgc tgtgggtgcc cggcagcacc       60

ggcgaccacg ccatctaccc caggcacggc agcggaagcg gcagcgtgcc cctggtgacc      120

gtgagcgccc tgccccccag cctgcccctg cccaggagct tcctgctgaa gagcctggag      180

caggtgagga agatccaggc cagcggcagc gtgctgctgg agcagctgtg cgccacctac      240

aagctgtgcc accccgagga gctggtgctg ctgggccaca gcctgggcat ccccaaggcc      300

agcctgagcg gctgcagcag ccaggccctg cagcagaccc agtgcctgag ccagctgcac      360

agcggcctgt gcctgtacca gggcctgctg caggccctga gcggcatcag ccccgccctg      420

gcccccaccc tggacctgct gcagctggac gtggccaact tcgccaccac catctggcag      480

cagatggaga acctgggcgt ggcccccacc gtgcagccca cccagagcgc catgcccgcc      540

ttcaccagcg ccttccagag gagggccggc ggcgtgctgg ccatcagcta cctgcagggc      600

ttcctggaga ccgccaggct ggccctgcac cacctggccg agctcggcag cggcagcgac      660

agggtgtaca tccacccctt tcacctgggc agcggaagcg gaggaagcgg aggaagcgga      720

ggaagcggca gcggaggaag cggaagcgga ggaagcggag gcagcggctc tagactgtgg      780

ccctggcccc agtacatcca gacctaccac aggaggtaca ccctgtaccc caacaacttc      840

cagttcaggt accacgtgag cagcgccgcc caggccggct gcgtggtgct ggacgaggcc      900

ttcaggaggt acaggaacct gctgttcggc agcggcagct ggcccaggcc cagcttcagc      960

aacaagcagc agaccctggg caagaacatc ctggtggtga gcgtggtgac cgccgagtgc     1020

aacgagttcc ccaacctgga gagcgtggag aactacaccc tgaccatcaa cgacgaccag     1080

tgcctgctgg ccagcgagac cgtgtggggc gccctgaggg gcctggagac cttcagccag     1140

ctggtgtgga agagcgccga gggcaccttc ttcatcaaca agaccaagat caaggacttc     1200

cccaggttcc cccacagggg cgtgctgctg gacaccagca ggcactacct gcccctgagc     1260

agcatcctgg acaccctgga cgtgatggcc tacaacaagt tcaacgtgtt ccactggcac     1320

ctggtggacg acagcagctt cccctacgag agcttcacct tccccgagct gaccaggaag     1380

ggcagcttca accccgtgac ccacatctac accgcccagg acgtgaagga ggtgatcgag     1440

tacgccaggc tgaggggcat cagggtgctg gccgagttcg acacccccgg ccacaccctg     1500

agctggggcc ccggcgcccc cggcctgctg accccctgct acagcggcag ccacctgagc     1560

ggcaccttcg gccccgtgaa ccccagcctg aacagcacct acgacttcat gagcaccctg     1620

ttcctggaga tcagcagcgt gttccccgac ttctacctgc acctgggcgg cgacgaggtg     1680

gacttcacct gctggaagag caaccccaac atccaggcct tcatgaagaa gaagggcttc     1740

accgacttca agcagctgga gagcttctac atccagaccc tgctggacat cgtgagcgac     1800

tacgacaagg gctacgtggt gtggcaggag gtgttcgaca acaaggtgaa ggtgaggccc     1860

gacaccatca tccaggtgtg gagggaggag atgcccgtgg agtacatgct ggagatgcag     1920

gacatcacca gggccggctt cagggccctg ctgagcgccc cctggtacct gaacagggtg     1980

aagtacggcc ccgactggaa ggacatgtac aaggtggagc ccctggcctt ccacggcacc     2040

cccgagcaga aggccctggt gatcggcggc gaggcctgca tgtggggcga gtacgtggac     2100

agcaccaacc tggtgcccag gctgtggccc agggccggcg ccgtggccga gaggctgtgg     2160

agcagcaacc tgaccaccaa catcgacttc gccttcaaga ggctgagcca cttcaggtgc     2220

gagctggtga ggaggggcat ccaggcccag cccatcagcg tgggctactg cgagcaggag     2280

ttcgagcaga ccggtaccca ccaccatcac catcactaa                            2319


<210>  44
<211>  993
<212>  DNA
<213>  Synthetic sequence

<400>  44
cactctgacc ctgcccgccg aggggagctg agcgtgtgtg acagtattag tgagtgggta       60

acggcggcag acaaaaagac tgcagtggac atgtcgggcg ggacggtcac agtccttgaa      120

aaggtccctg tatcaaaagg ccaactgaag caatacttct acgagaccaa gtgcaatccc      180

atgggttaca caaaagaagg ctgcaggggc atagacaaaa ggcattggaa ctcccagtgc      240

cgaactaccc agtcgtacgt gcgggccctt accatggata gcaaaaagag aattggctgg      300

cgattcataa ggatagacac ttcttgtgta tgtacattga ccattaaaag gggaagaggt      360

accggcagcg ccggcagcgc cgccggcagc ggcgagttcg tgcccctggt gaccgtgagc      420

gccctgcccc ccagcctgcc cctgcccagg agcttcctgc tgaagagcct ggagcaggtg      480

aggaagatcc aggccagcgg cagcgtgctg ctggagcagc tgtgcgccac ctacaagctg      540

tgccaccccg aggagctggt gctgctgggc cacagcctgg gcatccccaa ggccagcctg      600

agcggctgca gcagccaggc cctgcagcag acccagtgcc tgagccagct gcacagcggc      660

ctgtgcctgt accagggcct gctgcaggcc ctgagcggca tcagccccgc cctggccccc      720

accctggacc tgctgcagct ggacgtggcc aacttcgcca ccaccatctg gcagcagatg      780

gagaacctgg gcgtggcccc caccgtgcag cccacccaga gcgccatgcc cgccttcacc      840

agcgccttcc agaggagggc cggcggcgtg ctggccatca gctacctgca gggcttcctg      900

gagaccgcca ggctggccct gcaccacctg gccggaagcg gcagccacgc catctacccc      960

aggcacggca gccaccacca tcaccatcac taa                                   993


<210>  45
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  45
cactccgacc ctgcccgccg tggggagctg agcgtgtgtg acagtattag cgagtgggtc       60

acagcggcag ataaaaagac tgcagtggac atgtctggcg ggacggtcac agtcctagag      120

aaagtcccgg tatccaaagg ccaactgaag cagtatttct acgagaccaa gtgtaatccc      180

atgggttaca ccaaggaagg ctgcaggggc atagacaaaa ggcactggaa ctcgcaatgc      240

cgaactaccc aatcgtatgt tcgggccctt actatggata gcaaaaagag aattggctgg      300

cgattcataa ggatagacac ttcctgtgta tgtacattga ccattaaaag gggaaga         357


<210>  46
<211>  1383
<212>  DNA
<213>  Synthetic sequence

<400>  46
atgaccatcc ttttccttac tatggttatt tcatacttcg gttgcatgaa ggcggcgccc       60

atgaaagaag taaacgtcca cggacaaggc aacttggcct acccaggtgt gcggacccat      120

gggactctgg agagcgtgaa tgggcccagg gcaggttcga gaggtctgac gacgacatca      180

ctggctgaca cttttgagca cgtcatcgaa gagctgctgg atgaggacca gaaggttcgg      240

cccaacgaag aaaaccataa ggacgcggac ttgtacactt cccgggtgat gctcagcagt      300

caagtgcctt tggagcctcc tctactcttt ctgctggagg aatacaaaaa ttacctggat      360

gccgcaaaca tgtctatgag ggttcggcgc cactccgacc ctgcccgccg tggggagctg      420

agcgtgtgtg acagtattag cgagtgggtc acagcggcag ataaaaagac tgcagtggac      480

atgtctggcg ggacggtcac agtcctagag aaagtcccgg tatccaaagg ccaactgaag      540

cagtatttct acgagaccaa gtgtaatccc atgggttaca ccaaggaagg ctgcaggggc      600

atagacaaaa ggcactggaa ctcgcaatgc cgaactaccc aatcgtatgt tcgggccctt      660

actatggata gcaaaaagag aattggctgg cgattcataa ggatagacac ttcctgtgta      720

tgtacattga ccattaaaag gggaagaggt accggcagcg ccggcagcgc cgccggcagc      780

ggcgagttcg tgcccctggt gaccgtgagc gccctgcccc ccagcctgcc cctgcccagg      840

agcttcctgc tgaagagcct ggagcaggtg aggaagatcc aggccagcgg cagcgtgctg      900

ctggagcagc tgtgcgccac ctacaagctg tgccaccccg aggagctggt gctgctgggc      960

cacagcctgg gcatccccaa ggccagcctg agcggctgca gcagccaggc cctgcagcag     1020

acccagtgcc tgagccagct gcacagcggc ctgtgcctgt accagggcct gctgcaggcc     1080

ctgagcggca tcagccccgc cctggccccc accctggacc tgctgcagct ggacgtggcc     1140

aacttcgcca ccaccatctg gcagcagatg gagaacctgg gcgtggcccc caccgtgcag     1200

cccacccaga gcgccatgcc cgccttcacc agcgccttcc agaggagggc cggcggcgtg     1260

ctggccatca gctacctgca gggcttcctg gagaccgcca ggctggccct gcaccacctg     1320

gccggaagcg gcagccacgc catctacccc aggcacggca gccaccacca tcaccatcac     1380

taa                                                                   1383


<210>  47
<211>  1377
<212>  DNA
<213>  Synthetic sequence

<400>  47
atgaccatcc ttttccttac tatggttatt tcatacttcg gttgcatgaa ggcggcgccc       60

atgaaagaag taaacgtcca cggacaaggc aacttggcct acccaggtgt gcggacccat      120

gggactctgg agagcgtgaa tgggcccagg gcaggttcga gaggtctgac gacgacatca      180

ctggctgaca cttttgagca cgtcatcgaa gagctgctgg atgaggacca gaaggttcgg      240

cccaacgaag aaaaccataa ggacgcggac ttgtacactt cccgggtgat gctcagcagt      300

caagtgcctt tggagcctcc tctactcttt ctgctggagg aatacaaaaa ttacctggat      360

gccgcaaaca tgtctatgag ggttcggcgc cactccgacc ctgcccgccg tggggagctg      420

agcgtgtgtg acagtattag cgagtgggtc acagcggcag ataaaaagac tgcagtggac      480

atgtctggcg ggacggtcac agtcctagag aaagtcccgg tatccaaagg ccaactgaag      540

cagtatttct acgagaccaa gtgtaatccc atgggttaca ccaaggaagg ctgcaggggc      600

atagacaaaa ggcactggaa ctcgcaatgc cgaactaccc aatcgtatgt tcgggccctt      660

actatggata gcaaaaagag aattggctgg cgattcataa ggatagacac ttcctgtgta      720

tgtacattga ccattaaaag gggaagaggt accggcagcg ccggcagcgc cgccggcagc      780

ggcgagttcg ccacccctct gggccctgcc tccagcctgc cccagtcctt cctgctgaag      840

tgcctggaac aggtgcgcaa gatccagggc gacggcgctg ccctgcagga aaagctctgc      900

gccacctaca agctgtgcca ccccgaggaa ctggtgctgc tgggacacag cctgggaatc      960

ccttgggccc ctctgtcctc ctgccctagc caggctctgc agctggccgg atgcctgtcc     1020

cagctgcact ccggcctgtt cctctaccag ggactgctgc aggctctcga aggcatctcc     1080

cccgagctgg gccctaccct ggacacactg cagctggacg tggccgactt cgccaccacc     1140

atctggcagc agatggaaga actgggcatg gccccagctc tgcagcctac ccagggcgcc     1200

atgcctgcct tcgcctccgc cttccagaga agggctggag gagtgctggt ggcctcccac     1260

ctgcagtcat tcctcgaagt gtcctaccgc gtgctgaggc acctggccca gcccggaagc     1320

ggcagccacg ccatctaccc caggcacggc agccaccacc atcaccatca ctaatga        1377


<210>  48
<211>  1377
<212>  DNA
<213>  Synthetic sequence

<400>  48
atgaccatcc ttttccttac tatggttatt tcatactttg gttgcatgaa ggctgccccc       60

atgaaagaag caaacatccg aggacaaggt ggcttggcct acccaggtgt gcggacccat      120

gggactctgg agagcgtgaa tgggcccaag gcaggttcaa gaggcttgac atcattggct      180

gacactttcg aacacgtgat agaagagctg ttggatgagg accagaaagt tcggcccaat      240

gaagaaaaca ataaggacgc agacttgtac acgtccaggg tgatgctcag tagtcaagtg      300

cctttggagc ctcctcttct ctttctgctg gaggaataca aaaattacct agatgctgca      360

aacatgtcca tgagggtccg gcgccactct gaccctgccc gccgagggga gctgagcgtg      420

tgtgacagta ttagtgagtg ggtaacggcg gcagacaaaa agactgcagt ggacatgtcg      480

ggcgggacgg tcacagtcct tgaaaaggtc cctgtatcaa aaggccaact gaagcaatac      540

ttctacgaga ccaagtgcaa tcccatgggt tacacaaaag aaggctgcag gggcatagac      600

aaaaggcatt ggaactccca gtgccgaact acccagtcgt acgtgcgggc ccttaccatg      660

gatagcaaaa agagaattgg ctggcgattc ataaggatag acacttcttg tgtatgtaca      720

ttgaccatta aaaggggaag aggtaccggc agcgccggca gcgccgccgg cagcggcgag      780

ttcgtgcccc tggtgaccgt gagcgccctg ccccccagcc tgcccctgcc caggagcttc      840

ctgctgaaga gcctggagca ggtgaggaag atccaggcca gcggcagcgt gctgctggag      900

cagctgtgcg ccacctacaa gctgtgccac cccgaggagc tggtgctgct gggccacagc      960

ctgggcatcc ccaaggccag cctgagcggc tgcagcagcc aggccctgca gcagacccag     1020

tgcctgagcc agctgcacag cggcctgtgc ctgtaccagg gcctgctgca ggccctgagc     1080

ggcatcagcc ccgccctggc ccccaccctg gacctgctgc agctggacgt ggccaacttc     1140

gccaccacca tctggcagca gatggagaac ctgggcgtgg cccccaccgt gcagcccacc     1200

cagagcgcca tgcccgcctt caccagcgcc ttccagagga gggccggcgg cgtgctggcc     1260

atcagctacc tgcagggctt cctggagacc gccaggctgg ccctgcacca cctggccgga     1320

agcggcagcc acgccatcta ccccaggcac ggcagccacc accatcacca tcactaa        1377


<210>  49
<211>  458
<212>  PRT
<213>  Synthetic protein

<400>  49

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg Gly Thr Gly Ser Ala Gly Ser Ala Ala 
                245                 250                 255     


Gly Ser Gly Glu Phe Val Pro Leu Val Thr Val Ser Ala Leu Pro Pro 
            260                 265                 270         


Ser Leu Pro Leu Pro Arg Ser Phe Leu Leu Lys Ser Leu Glu Gln Val 
        275                 280                 285             


Arg Lys Ile Gln Ala Ser Gly Ser Val Leu Leu Glu Gln Leu Cys Ala 
    290                 295                 300                 


Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser 
305                 310                 315                 320 


Leu Gly Ile Pro Lys Ala Ser Leu Ser Gly Cys Ser Ser Gln Ala Leu 
                325                 330                 335     


Gln Gln Thr Gln Cys Leu Ser Gln Leu His Ser Gly Leu Cys Leu Tyr 
            340                 345                 350         


Gln Gly Leu Leu Gln Ala Leu Ser Gly Ile Ser Pro Ala Leu Ala Pro 
        355                 360                 365             


Thr Leu Asp Leu Leu Gln Leu Asp Val Ala Asn Phe Ala Thr Thr Ile 
    370                 375                 380                 


Trp Gln Gln Met Glu Asn Leu Gly Val Ala Pro Thr Val Gln Pro Thr 
385                 390                 395                 400 


Gln Ser Ala Met Pro Ala Phe Thr Ser Ala Phe Gln Arg Arg Ala Gly 
                405                 410                 415     


Gly Val Leu Ala Ile Ser Tyr Leu Gln Gly Phe Leu Glu Thr Ala Arg 
            420                 425                 430         


Leu Ala Leu His His Leu Ala Gly Ser Gly Ser His Ala Ile Tyr Pro 
        435                 440                 445             


Arg His Gly Ser His His His His His His 
    450                 455             


<210>  50
<211>  460
<212>  PRT
<213>  Synthetic protein

<400>  50

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Val Asn Val His Gly Gln Gly Asn Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Arg Ala Gly Ser Arg Gly Leu Thr Thr Thr Ser Leu Ala Asp Thr 
    50                  55                  60                  


Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
65                  70                  75                  80  


Pro Asn Glu Glu Asn His Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 
                85                  90                  95      


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
            100                 105                 110         


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
        115                 120                 125             


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
    130                 135                 140                 


Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
145                 150                 155                 160 


Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 
                165                 170                 175     


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 
            180                 185                 190         


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
        195                 200                 205             


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
    210                 215                 220                 


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 
225                 230                 235                 240 


Cys Thr Leu Thr Ile Lys Arg Gly Arg Gly Thr Gly Ser Ala Gly Ser 
                245                 250                 255     


Ala Ala Gly Ser Gly Glu Phe Val Pro Leu Val Thr Val Ser Ala Leu 
            260                 265                 270         


Pro Pro Ser Leu Pro Leu Pro Arg Ser Phe Leu Leu Lys Ser Leu Glu 
        275                 280                 285             


Gln Val Arg Lys Ile Gln Ala Ser Gly Ser Val Leu Leu Glu Gln Leu 
    290                 295                 300                 


Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 
305                 310                 315                 320 


His Ser Leu Gly Ile Pro Lys Ala Ser Leu Ser Gly Cys Ser Ser Gln 
                325                 330                 335     


Ala Leu Gln Gln Thr Gln Cys Leu Ser Gln Leu His Ser Gly Leu Cys 
            340                 345                 350         


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Ser Gly Ile Ser Pro Ala Leu 
        355                 360                 365             


Ala Pro Thr Leu Asp Leu Leu Gln Leu Asp Val Ala Asn Phe Ala Thr 
    370                 375                 380                 


Thr Ile Trp Gln Gln Met Glu Asn Leu Gly Val Ala Pro Thr Val Gln 
385                 390                 395                 400 


Pro Thr Gln Ser Ala Met Pro Ala Phe Thr Ser Ala Phe Gln Arg Arg 
                405                 410                 415     


Ala Gly Gly Val Leu Ala Ile Ser Tyr Leu Gln Gly Phe Leu Glu Thr 
            420                 425                 430         


Ala Arg Leu Ala Leu His His Leu Ala Gly Ser Gly Ser His Ala Ile 
        435                 440                 445             


Tyr Pro Arg His Gly Ser His His His His His His 
    450                 455                 460 


