                         SEQUENCE LISTING

<110>  CARDIOMIX
 
<120>  PROTEIN AND METABOLITE BLOOD BIOMARKERS FOR THE DIAGNOSIS OF 
       BRUGADA SYNDROME

<130>  P1933EP

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  19489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Prg4 human gene

<400>  1
taaaggaagg atctaaggaa aatatcaata cattttttaa gcagattttt aaaataataa       60

aggaagctag aaaatccagt gtcaataatc tacctgtagg taactgagag catgttttct      120

gtgctcagag aaaatgaaac tactcaagaa atgtatattt gatataatgg tataagtata      180

taaaatgtat gccacaagct aacactaggt aaatttcaaa gctacctttg ctagatttaa      240

ctggaaagca gaagaaataa atgataccag tatgtgaata ttttaaagtt gctgcttcaa      300

tatactagtc aaagtctgcc agagctattt accatctcag gacaatttgt tcacttcact      360

tagaaattag aaatgtgctc tggccaatac atctaaattt attttgtggt agtcattttg      420

cttaatggaa gtgttttcca gatgttgcct aagtctagtc gtctgggccc ttttccaata      480

aatgaggaaa gtttgatttc ataggttgtc actgttgatt ttgtctaacc tttggactaa      540

ttggttcatc ccactgtatt tgcactgata tataagactc ccaggacgtg ggataaactc      600

atctatcctt tacgggtaag tgtcaaagtt aacttgcttc atagaattaa atgtgttttc      660

attagaggtg tttgaaaaaa aatgtgtaaa gatagtagtt ggaaattttt gaaaaggatt      720

atgtttatgc aatacacctg ttggaagcct ttgaatttat attgagaatt aagaaaaagt      780

tggaacagta actccatgat gcttattaaa ttacatttct gtgacacagg ttattatttt      840

ccttaagata aaattttaac cttgcactgt taagtacatg ccatactttg gctagagttt      900

taagataagt ctattctata ttggagattt cttaagaatt aaaactgtca ataacgtggc      960

tgagggtgac ttgatttgtt ctgcataaga ttaagtctaa tggccaaata ttttctataa     1020

aattaaagct gatttaaagt cttgtttcaa gaatgggatg gttttattat tgttacattt     1080

ttaaagttac tgaaatgtgt ataatgcaag cctaagttag tggtgagatg aaagagctgt     1140

tttctgatac ttttatttta ttttcagcaa gggtacctac ggtacctgaa aacaacgatg     1200

gcatggaaaa cacttcccat ttacctgttg ttgctgctgt ctgttttcgt gattcagcaa     1260

gtttcatctc aaggtagctt aaccatcgaa catactttta tttaacaact attgctaatc     1320

attcagtctt gatttttata acaacggaaa tatatttcta aaaatttata tttgcttgag     1380

tttaatatac tgtacaacct taaaataata tataacatgt agcctgtttg taagtgcttt     1440

ggaattctca tctttttctc cttttgagag ttttgagctt gtataaagaa taattttggt     1500

acttgttatt tctatggttc tctcgaaagt ttaaaaagtg cagacagttc atcataaaat     1560

tatgctggag ctatatagta tcataaaaat aactaaaaaa gaacaatatt tagataacat     1620

gtaatttttg cctatatgtt gaacaatttg ttttttaaaa tcaaataaat tattgataaa     1680

taacttattt tggcatcatt tagacataga taccatatta taataaacta tagtgtttca     1740

aatggcattt tattagtctt gaaaatgttc tctttttctt acaagaacta tttatccagg     1800

tatggacata tacagatgtg actgtcattt tgtgttataa cattaaactt ttcacagttc     1860

tcccaaaaca ggtcctggat gaatagttct tgttactcat ttttagagac tgttaaagta     1920

cattcagtga aatcacatta gtaaaagatg ctagcatgcc atctaggggg attaatagta     1980

acaatgccaa gctttggatt tttcttttct tttcttttcc ttttgttccc ctttgataag     2040

caaaatctga gagaataaaa atcaagattc atgacagtta tgatgaaatt atgtttctaa     2100

agtaaacatt tccagtaaaa tacgagattc ttatgaaacc tgaacatgag tggtaactgt     2160

ctgcataggc ataagttgca gaattgttta gataagaaaa gacaggaaaa cacatgaaag     2220

caaatgtgaa tattcaataa gaatgatgac tactccagta tctccagacc cttcggcttt     2280

ctcgtaacac tatgacaagg ttcacaacac tgggggcact ttctaaactg ccttttcctc     2340

tgtgatacaa ttggttgttc actaaaacag tgttactttc attttaattg tgattaaata     2400

aatcaaatta aaattaatgg ggctgggtgt ggtggctcac acctgtaatc ccagcattct     2460

gggaggccta gggagacaga tcacctgagg tctggagttc aagagcagcc tgggcaacat     2520

ggcaaaatct tgtctctata caaaatacaa aaaaattagc caggtgtggt agtgtgtgcc     2580

tgtaatccca gctattcgga ggctgaggca agaggatatc ttgaatccag gaggtggagg     2640

ttgcattaag ctgagcttgc atcatggcac tccagcctgg gcaacagagt gagactctgt     2700

ctcaaaaata aataaataaa taaataaaat taatggttac aattaatagc aataaaagta     2760

ggacagacac ctaatctatg aaagtaagct tttcctgtaa ggatgatttc ctcttttttt     2820

tttttctttt gagacagggt cttgctttgt ctcccagtct ggagtgcagt ggcacaatct     2880

tggctcactg caacctccac ctacggggtt caagcgattc tcctgtctca gcctcccgag     2940

tagctgggat tacaggcccc tgccaccatg cccggttaat ttttgtattt ttagtaaaga     3000

caggttttca ccatgttggc caggctggtc tcacctgacc tcaggtgatc cgcccgcctc     3060

agcctcccaa agtgctggaa ttacagatga tttcttattt cagaaatctg ccaactataa     3120

aagagcaatc tcttgatact gtcttgtctg cttctcttgc tttctcaacc tcttctcatt     3180

ctcttttttc tttatatata atatatgtat ttatatacat acactatata tacatttttg     3240

tatgcattat gcactcatgt acgcaaaaag ttctgaaagt tgtcctacaa tttactgttt     3300

tatttgcata ttcagacttt ggcattcctg gactctattc ttttaagatt tgttttcagt     3360

gtgtttcaac attcctttgt ggatttagga cagtacacct gccaatttct attccaggga     3420

tggattccat tgtcacattt ctgcagtcat ttctcaggga gggttttaag gtggtgtttt     3480

ccaaatgact tttaaaaaat atttgagaat gagtatgctt ttgttattgt ttgcttattt     3540

gttgcctgga aaacctctgt tcatgacctt tatagttatg cccagttatt ttaagggttc     3600

tcacttcagc agtggttgta agcatctgcc tcccctgaca ttttaaaaat ccagttatcc     3660

ccaccaatta aggaagaaaa agctcagtaa agtttatgct ggtgcaacca gcgtgcttta     3720

aacttatcct caggaatggg aggcaaagcg acaggtggaa acatctcagg cttaaaataa     3780

gatatatcag agttcaaatt ctggatggat tgtttactta aggtgaccat aaaatgtatt     3840

atctaaatta ggacaattat aagggtaaaa gagttcacta caaataattg ggaggtatta     3900

attaacctat gatgccaata tactggaact attaactagt cgtgtgataa tgagcaagtt     3960

gtcaaaattt ctgtgtttca gctttcttag ctctaaaaaa gggctactaa atcctggaaa     4020

cattttcata agcattagtg ataatgtatg actcagcacc tggcatagag aagctcaata     4080

aatggcaact gctaatcatc aaaaccacag atcggtagta gctgtagctg ccacctcttc     4140

cttaggagta tcaccctctt taggcaaagc cattactttg cctggttttc aaaaatgtgt     4200

ttatcatctc agtctagtga agaataaagt gacataattg agatcaccta agacatcagc     4260

caaatatcag ctgggcctat tgctgacatc attccaacac cttctcgatc aataaaattc     4320

tctctcacca agtggctttg tccccctcgt tagattgctc cctttctata aagtggtttg     4380

gccatattta cgccagtatt gtataatttt agatttatca agctgtgcag ggagatgtgg     4440

ggaagggtat tctagagatg ccacctgcaa ctgtgattat aactgtcaac actacatgga     4500

gtgctgccct gatttcaaga gagtctgcac tgcgggtaag tcctgagagc gggtgtctcc     4560

tctgtcaagc aacactgcga gtctgtgagt ccccccttgc accctcgtgc agtgctgtga     4620

gactgagcct ccccttgcac ccacttgcag tgctgttttc ccactgtatc acttcctttg     4680

cttaagtgac tttccttcac ttgcataaat gttgcagcgc attgtaccta aggatggtgt     4740

caaagcttgt gattattggg gagggtaagg ggagcctgga agtctgtcac ttgcacaagg     4800

ttattgtcta gttccaagta aatgtcttat tttaaataga gaagatactg tgagtcagga     4860

gtcattaagt aaatagtaag gagtaattat ttacaatcag agatgtcctc gactagtaat     4920

gaggactttc aatagtttca tcaaaagaat acatgagcat ggaataatct tgtctaccat     4980

tggactttct gatgttaaca cgtttgtaaa ttacctggaa aagacacttt aaagataaag     5040

tgctagtgtt taatgatgaa tttcagttaa aatctgaagg tctgaatttt aaattatgag     5100

tggtgtttca cttgaatata ttttgggcca ttttattatt aacacagaaa catttcctat     5160

tcaatttaag aaaattgtaa ttaaagttat ttgaaaggtg tatttgcttt agaatttgaa     5220

tgtgaagttg aggaatatat tgtgcaattt atgtattgga taggtaatta tttcaaataa     5280

gccttggtaa gtccctgtta actctaacaa aggcttttta aattttcatt ttttaaatga     5340

gtagtcctcc ctaacatagt ccacactgta agattaggct gaaagctttc aactatacac     5400

cttccccagt ttgtcataat aagggcctct gcattacaaa tgatttttaa gcctcaaaaa     5460

tgacccattt acgtggaata tatatacata tatatttata tggaatatat tgctgagatc     5520

tgtacattca attactgtga atctattaca aagcagtgtg tgaagaggag aaggatgaag     5580

agatttcata tgaaggctat ctcactatct agacatttcc cgatttttct ttgtccatac     5640

atgtaaataa ctcgggcagc atcaggatgt ctcttggagt ctggaagggc aagaggagtt     5700

gccctcagtc accatatttc ttttttgact tgggctgtct ccatctggga taccatctaa     5760

tttttcctgg atgatgtact ccaaatttca aataaaagac ttagaaatga acttttggaa     5820

acctagtcaa gtctaaggtg ggaaatggct gtcaaatacg tgggcctggc ttcacaatga     5880

ataatctgta acttcttgtt ttgctctggg tagagctttc ctgtaaaggc cgctgctttg     5940

agtccttcga gagagggagg gagtgtgact gcgacgccca atgtaagaag tatgacaagt     6000

gctgtcccga ttatgagagt ttctgtgcag aaggtaagca tcacagtacc aaccaatgct     6060

tctcagtaca gccagatctg tgcacctacc ttagcatcac tgataatgtc taacacgcag     6120

tccatcttag gccttgattt tactaacata taagctattt cataataatt ttgttttgtg     6180

gagatgaatt aaagaagaaa agcgccttcc aacagcagaa cccccaggct cagccaggct     6240

ccaagagtac aagatgttgc cagaggggga acatagagga tgaggctgaa tgtatatgtc     6300

ttttttttct tcagatatgg ttcaatttca ggttaaatca acagtaatca aatcacttga     6360

tgatttcttg tctcaccctt gctgacttca cgaagtcaac tatcctttga gctatctgtg     6420

cttttggcct cagtgtttga gtatatattt aaggacataa gcaacacttt cagcttccct     6480

aaaccagtaa atttatgaat tagtttaagc cattaaattt ataggcaaat ctacctaaca     6540

cgttgttaac tgtcatgttc cttcccattt ctgcagtctc ctcagcagtc tctattccaa     6600

tacatgtgca tggtaaagtc aataacaagg gatattccca tcttaaaatc aaattctcta     6660

tttataggtc ttgaaggact cctctagagt ataacaaaag gctccagatt ttacagaaaa     6720

agattttaaa aatatacttg aatactggat tactttcctt taccaaatgg ttgttcttaa     6780

attctacttt gttaaaacaa gaatatttgt ggaggtaaaa gtgaaaataa gctttgcttg     6840

cataatcaat cttatcattt tatttaaaca agcctgcgct tcctgcttct ttagaacagt     6900

gaagaaagat cggaaaactg ctaatcagca gaattgagag atgtttctta accgttcaat     6960

gttttcatgg gaaaacattc caaaaatgat gaagacaaca cccttgtaat aaaaacctta     7020

gagctcaccc ttcctgcaga ttttagcagg ccccatgatg agtgacacat atttactcat     7080

taccctaatt gttttggctg tgagacaaga aagctaagaa tttgttttgg gcagaggatg     7140

tctagggagt gaagatggtt agaaagtgat gagacattga gagaacattt tgataaagat     7200

aatactttat gttatgaaat atttggtcag attacctaaa gtttaggtag aactctgaaa     7260

aaaaaatgat gaaggcgatg ctggccaact ttctttacag aattcataag acagtcagcg     7320

tcccaactta aaataataaa accactcaga acctcaatac ttcatttttt aagtgtaata     7380

accaaactat cttgagattc actacttagt tgtttcagta tagatactac ttacaggtgt     7440

ctatatatct aaaaatcata acatttcaag aattgaagga atcccagcca tccaagtgcc     7500

tctgaatgtg aaagagaaaa cagagtccaa gaggttaacc attttggcca agaacattag     7560

ctagtacatg gcagatctgt ttctcaaatt gagatacttg atgtttttgc tgggtaggag     7620

gagaaacaag agggacagtg gccagttcac ggagactata gcagtagggt tctggggcga     7680

tgttgcgggg agcagcatga tttatcacaa cccttctgta cccagagagt ccccagtgct     7740

gttttcttat ccttcattag tccctcttct tgttcctaaa aaaaaaaaaa aaaaagaagt     7800

tccatgtttt ctcttctaga ctgagaagcg gaaaagggaa ggggactaaa aggttaaaaa     7860

gatacacacc aaaccattaa gttgtatctt tgggaagggc agggcatttt gaggaaaagc     7920

acaatgtgaa ggtgtgaact tttcacaaga atattcatgt agaacttttg taattaaaaa     7980

aagaacaaaa ggcaaattgg catcatttaa tttaaatgaa tattaaaaca gaaaaaaatg     8040

aatactaaaa cagaaaaaaa ttctgaaggc aaagaccttc agaaatcatc ttgaataaac     8100

atcttagttt gtagacaaga agatgaagtt caagataatt atttgcctaa ggtcacaatg     8160

gtagaggctc gcaggcctag gactggaatt taggtcttct gattcctgag actttgctcc     8220

ctgtcataac ttacaacaat ttgagaacca gtattttata gcaatgcatc cttagactta     8280

aatggagtca ttcgtgttga gctggagcct gcctgcactg gctgtcacca gcatctactc     8340

ttgaagctag atgcatctgt gcttttcaca gttagagctg ctgatgaaca taaacaagat     8400

gttaactgac ttgtcttact tggcctcagt gcataatccc acatcaccac catcttcaaa     8460

gaaagcacct ccaccttcag gagcatctca aaccatcaaa tcaacaacca aacgttcacc     8520

caaaccacca aacaagaaga agactaagaa agttatagaa tcagaggaaa taacagaagg     8580

taggaagatg acagatataa tcaaaggagc tttcttagat gaagtaactt gtaggtgact     8640

gcttatctaa gcccattctc agagaacagg gtaatcttag gaatcatgag cctcattaca     8700

ctcgaaggtt ttagactttg cttttaagta aagtttaaga caaagtataa actctcagct     8760

ctttctgtat ttaccaaacc cagcatgagt ctgggttaaa acaaatcaga agggacaaat     8820

cttactataa aaaacaaaaa ccaccccatg attttctttg tagaataatt tgattctgtg     8880

ttttggagga tatgggaaag ttgagagata ctagtaatac tgctagtatc tgtgataagc     8940

ccaggtgcct tgcttttaac tgacagatta aaaggcagtt ggtcatatta ctaataaaag     9000

caaaatccag atacttgtag actagtaaat agcacttctt gctgtgttta gactggtggt     9060

tcttttttgt tttaaatcac agttggtgtg atcaaacttt ctatttgatt tatagaacat     9120

tctgtttctg aaaatcaaga gtcctcctcc tcctcctcct cttcctcttc ttcttcaaca     9180

attcggaaaa tcaagtcttc caaaaattca gctgctaata gagaattaca gaagaaactc     9240

aaaggtttga gcattgataa agatcaaaga ctgtatcaat gccatattaa caatgattat     9300

atttaaaagt aatgcgtgtt ggcagaatga ggacatctta atatgggggg gaatataact     9360

ttatgaatat tatcttagaa agtaccaaat gaatacttcc tacaggaaat tagtgccaag     9420

cggctaagaa gccactctaa aagcaaagga taagaagatg ctgtagcagg actgtggaac     9480

cacaagatgg caccagagat gattattgat ggctttctac tgtcattctt gtttacttga     9540

catcattttg cttcttctcc ttcatcttcc ttgcattttc attttccctt ccccagcttt     9600

attttaacaa acatttatat actattgttc taagtgtttt acaagtatta actcattaaa     9660

ttcttacaaa cctctatgga aaaaatatta tccatatttt acaaatcctc tttattttcc     9720

tagtaactta tatattatat ctggctgact tttcctctag tagagactgt gctacagaat     9780

aggctattat tgcctgaaaa gagatttcct ttgctgttta ttatttcctg aagttctggt     9840

tctaaatata tattctcttt ctccaggaaa tactggattt ttggataagg gagttttaaa     9900

gaactctaag aggttgtgat ttcctccgaa gcattcgctc taaataaata gccaggcatt     9960

taatctttta gtcacccaga aaatcgtgca ggaagccacc cttgggcttt gtagtccaca    10020

tgtggggcag ctgctatggg aaagccttga taaatactgt ctttttgctg cccatcacac    10080

cctaagctcc tccttatgtc ccctgggacc tgcaaggtta gctgcgcaga agaaaaggag    10140

tggctaatag ccctatgtat gggaacaagg ctcagcaggg actgtggggg tgactggggc    10200

agattgctca gaggtagctg tagaggcctc tgagataatt ggtgcagcaa gatggtagta    10260

ctaggtttcc aggaggaagg aagggacact gggcactgaa gaataagagt acaaaaagta    10320

gggggtaaag aacattaata taaacagatg aattagtgtt atttatcgtg ttggtaattt    10380

tgaacttgcc actgacttcc atgtattaat tgtatagagt tttatttgtg ctttttcatc    10440

cctcatctca tttattccct aaaacagccc aataagatag gttgagtatt tgccatttta    10500

caacaaatta aaggacatag tagagattag caatttgctt agaaacacac aactagtcaa    10560

tgataaagat gggatcttta tgtcactatt aaagaaaaaa aaatattcta aaataacaag    10620

atgtatattt tttctccagt aaaagataac aagaagaaca gaactaaaaa gaaacctacc    10680

cccaaaccac cagttgtaga tgaagctgga agtggattgg acaatggtga cttcaaggtc    10740

acaactcctg acacgtctac cacccaacac aataaagtca gcacatctcc caagatcaca    10800

acagcaaaac caataaatcc cagacccagt cttccaccta attctgatac atctaaagag    10860

acgtctttga cagtgaataa agagacaaca gttgaaacta aagaaactac tacaacaaat    10920

aaacagactt caactgatgg aaaagagaag actacttccg ctaaagagac acaaagtata    10980

gagaaaacat ctgctaaaga tttagcaccc acatctaaag tgctggctaa acctacaccc    11040

aaagctgaaa ctacaaccaa aggccctgct ctcaccactc ccaaggagcc cacgcccacc    11100

actcccaagg agcctgcatc taccacaccc aaagagccca cacctaccac catcaagtct    11160

gcacccacca cccccaagga gcctgcaccc accaccacca agtctgcacc caccactccc    11220

aaggagcctg cacccaccac caccaaggag cctgcaccca ccactcccaa ggagcctgca    11280

cccaccacca ccaaggagcc tgcacccacc accaccaagt ctgcacccac cactcccaag    11340

gagcctgcac ccaccacccc caagaagcct gccccaacta cccccaagga gcctgcaccc    11400

accactccca aggagcctac acccaccact cccaaggagc ctgcacccac caccaaggag    11460

cctgcaccca ccactcccaa agagcctgca cccactgccc ccaagaagcc tgccccaact    11520

acccccaagg agcctgcacc caccactccc aaggagcctg cacccaccac caccaaggag    11580

ccttcaccca ccactcccaa ggagcctgca cccaccacca ccaagtctgc acccaccact    11640

accaaggagc ctgcacccac cactaccaag tctgcaccca ccactcccaa ggagccttca    11700

cccaccacca ccaaggagcc tgcacccacc actcccaagg agcctgcacc caccaccccc    11760

aagaagcctg ccccaactac ccccaaggag cctgcaccca ccactcccaa ggaacctgca    11820

cccaccacca ccaagaagcc tgcacccacc actcccaaag agcctgcccc aactaccccc    11880

aaggagactg cacccaccac ccccaagaag ctcacgccca ccacccccga gaagctcgca    11940

cccaccaccc ctgagaagcc cgcacccacc acccctgagg agctcgcacc caccacccct    12000

gaggagccca cacccaccac ccctgaggag cctgctccca ccactcccaa ggcagcggct    12060

cccaacaccc ctaaggagcc tgctccaact acccctaagg agcctgctcc aactacccct    12120

aaggagcctg ctccaactac ccctaaggag actgctccaa ctacccctaa agggactgct    12180

ccaactaccc tcaaggaacc tgcacccact actcccaaga agcctgcccc caaggagctt    12240

gcacccacca ccaccaagga gcccacatcc accacctctg acaagcccgc tccaactacc    12300

cctaagggga ctgctccaac tacccctaag gagcctgctc caactacccc taaggagcct    12360

gctccaacta cccctaaggg gactgctcca actaccctca aggaacctgc acccactact    12420

cccaagaagc ctgcccccaa ggagcttgca cccaccacca ccaaggggcc cacatccacc    12480

acctctgaca agcctgctcc aactacacct aaggagactg ctccaactac ccccaaggag    12540

cctgcaccca ctacccccaa gaagcctgct ccaactactc ctgagacacc tcctccaacc    12600

acttcagagg tctctactcc aactaccacc aaggagccta ccactatcca caaaagccct    12660

gatgaatcaa ctcctgagct ttctgcagaa cccacaccaa aagctcttga aaacagtccc    12720

aaggaacctg gtgtacctac aactaagact cctgcagcga ctaaacctga aatgactaca    12780

acagctaaag acaagacaac agaaagagac ttacgtacta cacctgaaac tacaactgct    12840

gcacctaaga tgacaaaaga gacagcaact acaacagaaa aaactaccga atccaaaata    12900

acagctacaa ccacacaagt aacatctacc acaactcaag ataccacacc attcaaaatt    12960

actactctta aaacaactac tcttgcaccc aaagtaacta caacaaaaaa gacaattact    13020

accactgaga ttatgaacaa acctgaagaa acagctaaac caaaagacag agctactaat    13080

tctaaagcga caactcctaa acctcaaaag ccaaccaaag cacccaaaaa acccacttct    13140

accaaaaagc caaaaacaat gcctagagtg agaaaaccaa agacgacacc aactccccgc    13200

aagatgacat caacaatgcc agaattgaac cctacctcaa gaatagcaga agccatgctc    13260

caaaccacca ccagacctaa ccaaactcca aactccaaac tagttgaagt aaatccaaag    13320

agtgaagatg caggtggtgc tgaaggagaa acacctcata tgcttctcag gccccatgtg    13380

ttcatgcctg aagttactcc cgacatggat tacttaccga gagtacccaa tcaaggcatt    13440

atcatcaatc ccatgctttc cggtattaag aatcagttat tttcattttt aaagctggta    13500

atgttagttt acatctatct gaaccagaat gccttagttt agtatcactc aactgagata    13560

tattacctga ccttgttagc ttgtgaagtt ttacagcttc cctgtaggta agcagaggtg    13620

taattacagt aagctttttc attctctaga aaattaagcc tgggaattta gcatatgtgt    13680

gtctgtgagc agcagagatg gtatatagaa agtcaaaaaa atttagttcg gagtctattc    13740

ttaaaagtac aatgcaaagc aaaaatctgt agtatcattt tccaaactaa cccaaaggga    13800

gggcaatcag aactgaaaga tgcaatttca cattgagttc atacatccaa aaaatgtcta    13860

gtttacatga aaatcaaggt aacctggtcc attccaattc ataataattt atttcatata    13920

atacttttga agagtatcat ctttaagtaa aatggaatta tcaagtatat aactatgcaa    13980

acaggtcaaa ctgtgtcctt caagatctta gaaaaggtaa acaggaaata gaaccatgtg    14040

gaaagacttg aaaagaacat acagactttt ctcattctgt tctatatttg ttttgttttt    14100

gttaatttgt ttagatgaga ccaatatatg caatggtaag ccagtagatg gactgactac    14160

tttgcgcaat gggacattag ttgcattccg aggtgagcta tgtacacatt tatttttctt    14220

ctcatcattc tgttttggca tttatgagaa ccaaagccgt ggaagagtgc tagtttgggt    14280

tgttttctgg aggggaatct gattgataag cacacctcac aggagaatcc gagagtaata    14340

acagaaatat tggattaaga aaattagaca aagtaacaaa acaaaaccaa gaccctgaac    14400

tgatactact gaggtttttt cctactgtta agatttaaaa agtagttcat tttttttggg    14460

gggggggggt agttaaaatt taaaaaataa aataaaattt taatttcata ccaaatgaaa    14520

tgacaccagc atgcatattc actgctttat ttgaaaataa catctcaatt gtgatgtgtt    14580

caagtgttac actctctgtc ggagagtaac agaagaaaag ttatttcatg ttaattctct    14640

gctgtactct gctagtccag tcttgaaaca tatttagatt aaatctgaaa gcaattcctt    14700

ttcgtacagt agaggctaaa gagatgttag tcattaaatt ataattcctt agttctaaga    14760

gataaagaaa ttgagatcta aagagatagt gactgtaagt cacaaagcca aaaggctttt    14820

ttgagaccgg atctccctct gtcacccagg ctggagtaga gtggtgcaat tacggctcaa    14880

tgcaggctcg atctcctggg cccaagtgat cctcccatct cagccacctg agtagctggg    14940

actacaggtg tgcaccacca tgcctggcta atttttgtat ttttttttgt attttttttt    15000

ttttgtagag acagggtttt gtcatggtgt ccacgctggt ctcaaactcc tgggcccaag    15060

ccatctaccc gccttaacct cccaaagtgc tggattacag gtgtgagcca ctgcacctgg    15120

cccaaccaat aggctctttc taaagaaact agaaaactaa agtatctcaa aggttatgct    15180

aaatttcgga cttgggaaat acctgctctc agaaatgttc aaatactacc ttttgtatct    15240

gactaaactt ccagtcatac aatgcataag aaaactacat tttttttcat tttggtttct    15300

tttgtgatag gtttagcatt cagcttgtag gctgatgtct ttccttaaat tttaggtcat    15360

tatttctgga tgctaagtcc attcagtcca ccatctccag ctcgcagaat tactgaagtt    15420

tggggtattc cttcccccat tgatactgtt tttactaggt gcaactgtga aggaaaaact    15480

ttcttcttta aggtaacaca aatatctttg tgagagaaat ttaataataa tttgtaactg    15540

cattatttat tacaacatat attgccttaa cctccaatat gtgtcctttt aaatactctg    15600

tcatcaaaat ttaatcataa ttcaacagtt tgataacagt aatggtcaaa attcaaccgt    15660

ttaaccaagt taacacgttc tctctatact taaatctaga aaggagttcc aaatcttttt    15720

tcccaaagct gataacataa ttttctcttt taaattatca ggattctcag tactggcgtt    15780

ttaccaatga tataaaagat gcagggtacc ccaaaccaat tttcaaagga tttggaggac    15840

taactggaca aatagtggca gcgctttcaa cagctaaata taagaactgg cctgaatctg    15900

tgtatttttt caagagaggt atgtgttaca taattgacaa gattacaaaa cttttaaaga    15960

attacactca gcattttcat ttattattga ctttactgtc aaaagatatc tttaatggct    16020

gaaatcaaat attttcagtg aaaaaaatca atattgaggg tagtattctt attgccctca    16080

atttttattt tcatttcttc acaggcaagt cacaattcat ttgagttttc aggtcactga    16140

tagaatgtca tttactttcg cttcacaaat gtgcatgtca tccttgcaca agggccatgc    16200

taatctctgt atcattccag ttttagtata tgtgctgcca aactgagcac ttgtcacttt    16260

caattgaaat taaatatata actatgtaat ttgctgcatc tattcattca acaagtattt    16320

cagtttaata attattttta taataccctt gactaatagc cattattaat atcaatatat    16380

tatatgaaaa atgagaacaa aactgtttcc tatacattgt aaaagttgtt ttccaccttt    16440

tctgagggta ttaaaattaa ttttcatttt ccatgtgata ttctaataca taacaggtgg    16500

cagcattcag cagtatattt ataaacagga acctgtacag aagtgccctg gaagaaggcc    16560

tgctctaaat tatccagtgt atggagaaac gacacaggtt aggagacgtc gctttgaacg    16620

tgctatagga ccttctcaaa cacacaccat cagaattcaa tattcacctg ccagactggc    16680

ttatcaagac aaaggtaaca tttttattgt gttaaaaaaa tccttaaaca taagtagatg    16740

taatacagtt tcttatacag taaggcttat gaaatatgga tactgatcaa acagccctaa    16800

taatttaagc ttactgatga aaaactcatc cacttgcctt agtgaataac caaagaccaa    16860

tactttcttt ttccttgtgg gtaagtaaag cagtttgttc aggtttgtta gttataacca    16920

atactattta tcaagtactt cttaccaaga acattatata ccagtctata accctcaata    16980

gttctacatc agagggctaa aactgagatt aaaactcaga tgtctggctc tttccaagat    17040

agtacattgc cttttaatct ggtatctttt attaaacatg ccacttacag gtgtccttca    17100

taatgaagtt aaagtgagta tactgtggag aggacttcca aatgtggtta cctcagctat    17160

atcactgccc aacatcagaa aacctgacgg ctatgattac tatgcctttt ctaaaggtaa    17220

ggtattaact aacagtttcc caaggaggtg atatcatttg tgaaaacatg aagataaagt    17280

aaaaatgctg gctgcaatga tgactgaatg tgagaagtta cactacggta cttattctaa    17340

ttgctgtgga aaagagttaa gacttttgct ttaatttcaa ttaaaatgat ggcactgcaa    17400

ttcaattctg ctctaacctt catgagatta cgataaaaca tccagttact agagtaaact    17460

tgctactgac aatagtattt tacttctatc atttgtggca tttaacagat accttgtttg    17520

gcacaaggtt ataatgattt gcatcactgc agagtctgta agatcagaaa gaagttcctg    17580

agaaactaat tttattaatt aaattatatt actcaggatg cttttctttg aaatgcccag    17640

aaatctaagt tattctgcct gtaatttcat aatatgaatg acattggcat gtatttttta    17700

aaaggaataa ccccaagtaa attatttttc aaacttggtt actctttaat gtttacttca    17760

taaaggagag ctgaacctga ttttacaaaa agatggtgaa atgtcaatct tttgaaacat    17820

caaaaaagct gaaaagtcta ggcaattgtt tttctttttg ttataaagtt caaattaatt    17880

agtaaaaaca tctctattaa aatgataaac attgtctttg agcataatag tcaacataag    17940

ttatttttta gtttgggcat tgttttcttt ttaactaaaa aaatgttttc tcttccattt    18000

agatcaatac tataacattg atgtgcctag tagaacagca agagcaatta ctactcgttc    18060

tgggcagacc ttatccaaag tctggtacaa ctgtccttag actgatgagc aaaggaggag    18120

tcaactaatg aagaaatgaa taataaattt tgacactgaa aaacatttta ttaataaaga    18180

atattgacat gagtatacca gtttatatat aaaaatgttt ttaaacttga caatcattac    18240

actaaaacag atttgataat cttattcaca gttgttattg tttacagacc atttaattaa    18300

tatttcctct gtttattcct cctctccctc ccattgcatg gctcacacct gtaaaagaaa    18360

aaagaatcaa attgaatata tcttttaaga attcaaaact agtgtattca cttaccctag    18420

ttcattataa aaaatatcta ggcattgtgg atataaaact gttgggtatt ctacaacttc    18480

aatggaaatt attacaagca gattaatccc tctttttgtg acacaagtac aatctaaaag    18540

ttatattgga aaacatggaa atattaaaat tttacacttt tactagctaa aacataatca    18600

caaagcttta tcgtgttgta taaaaaaatt aacaatataa tggcaatagg tagagataca    18660

acaaatgaat ataacactat aacacttcat attttccaaa tcttaatttg gatttaagga    18720

agaaatcaat aaatataaaa tataagcaca tatttattat atatctaagg tatacaaatc    18780

tgtctacatg aagtttacag attggtaaat atcacctgct caacatgtaa ttatttaata    18840

aaactttgga acattaaaaa aataaattgg aggcttaagg attagaaaac ttgttccatt    18900

tattactatt ccacattcta tcatgtaatc cagttatgtc agaaattcac ctctctgtct    18960

gttaaactga cgaccacgga caccttgtct caatgttgtc tgaagtctta ctcgtctgaa    19020

aggctttggt tgactactac tagtatctaa gaaaaacatt aagataaaag aaaagcaagt    19080

gaaaaaatga gaaagcattt ataatgatac aaactaatta ctaaatgaat gaatgaataa    19140

gatgtagact tgttcatttg atttcaattc tttttttcaa acaatgagga acatttaaca    19200

aaccgaaaaa gggtaaatgg ttaaacaaca aaaaaagcag cactttggga ggctaaggtg    19260

ggaggatcac ttgagctcag gagttcgaga ccagcctggg caacacagcg agaccctgtt    19320

tctacaaaat tataaaacaa ttagctgggc atggtggaac atgcctacag tcccagttac    19380

tcaggaggct gaggctagag gatcacttga gcccgggtga ggttgaggct gcagtgagcc    19440

atgatcaagc taacagtact ccagggagac cggtgagatc ctgccttaa                19489


<210>  2
<211>  1404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated PRG4 protein (aminoacid change R180->W)

<400>  2

Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      


Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          


Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              


Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  


Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  


Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      


Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         


Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             


Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 


Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Thr Ile Trp Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg 
            180                 185                 190         


Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr 
        195                 200                 205             


Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser 
    210                 215                 220                 


Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr 
225                 230                 235                 240 


Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys 
                245                 250                 255     


Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys 
            260                 265                 270         


Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu 
        275                 280                 285             


Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr 
    290                 295                 300                 


Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp 
305                 310                 315                 320 


Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu 
                325                 330                 335     


Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro 
            340                 345                 350         


Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             


Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 


Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 


Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     


Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            420                 425                 430         


Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro 
        435                 440                 445             


Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 


Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 


Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
            500                 505                 510         


Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
        515                 520                 525             


Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    530                 535                 540                 


Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro 
545                 550                 555                 560 


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
                565                 570                 575     


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            580                 585                 590         


Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        595                 600                 605             


Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu 
    610                 615                 620                 


Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro 
625                 630                 635                 640 


Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro 
                645                 650                 655     


Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala 
            660                 665                 670         


Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        675                 680                 685             


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
    690                 695                 700                 


Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro 
705                 710                 715                 720 


Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr 
                725                 730                 735     


Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr 
            740                 745                 750         


Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
    770                 775                 780                 


Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
785                 790                 795                 800 


Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp 
                805                 810                 815     


Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
            820                 825                 830         


Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu 
        835                 840                 845             


Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys 
    850                 855                 860                 


Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu 
865                 870                 875                 880 


Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro 
                885                 890                 895     


Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr 
            900                 905                 910         


Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro 
        915                 920                 925             


Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr 
    930                 935                 940                 


Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val 
945                 950                 955                 960 


Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu 
                965                 970                 975     


Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile 
            980                 985                 990         


Thr Thr Thr Glu Ile Met Asn Lys  Pro Glu Glu Thr Ala  Lys Pro Lys 
        995                 1000                 1005             


Asp Arg  Ala Thr Asn Ser Lys  Ala Thr Thr Pro Lys  Pro Gln Lys 
    1010                 1015                 1020             


Pro Thr  Lys Ala Pro Lys Lys  Pro Thr Ser Thr Lys  Lys Pro Lys 
    1025                 1030                 1035             


Thr Met  Pro Arg Val Arg Lys  Pro Lys Thr Thr Pro  Thr Pro Arg 
    1040                 1045                 1050             


Lys Met  Thr Ser Thr Met Pro  Glu Leu Asn Pro Thr  Ser Arg Ile 
    1055                 1060                 1065             


Ala Glu  Ala Met Leu Gln Thr  Thr Thr Arg Pro Asn  Gln Thr Pro 
    1070                 1075                 1080             


Asn Ser  Lys Leu Val Glu Val  Asn Pro Lys Ser Glu  Asp Ala Gly 
    1085                 1090                 1095             


Gly Ala  Glu Gly Glu Thr Pro  His Met Leu Leu Arg  Pro His Val 
    1100                 1105                 1110             


Phe Met  Pro Glu Val Thr Pro  Asp Met Asp Tyr Leu  Pro Arg Val 
    1115                 1120                 1125             


Pro Asn  Gln Gly Ile Ile Ile  Asn Pro Met Leu Ser  Asp Glu Thr 
    1130                 1135                 1140             


Asn Ile  Cys Asn Gly Lys Pro  Val Asp Gly Leu Thr  Thr Leu Arg 
    1145                 1150                 1155             


Asn Gly  Thr Leu Val Ala Phe  Arg Gly His Tyr Phe  Trp Met Leu 
    1160                 1165                 1170             


Ser Pro  Phe Ser Pro Pro Ser  Pro Ala Arg Arg Ile  Thr Glu Val 
    1175                 1180                 1185             


Trp Gly  Ile Pro Ser Pro Ile  Asp Thr Val Phe Thr  Arg Cys Asn 
    1190                 1195                 1200             


Cys Glu  Gly Lys Thr Phe Phe  Phe Lys Asp Ser Gln  Tyr Trp Arg 
    1205                 1210                 1215             


Phe Thr  Asn Asp Ile Lys Asp  Ala Gly Tyr Pro Lys  Pro Ile Phe 
    1220                 1225                 1230             


Lys Gly  Phe Gly Gly Leu Thr  Gly Gln Ile Val Ala  Ala Leu Ser 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Lys Asn Trp  Pro Glu Ser Val Tyr  Phe Phe Lys 
    1250                 1255                 1260             


Arg Gly  Gly Ser Ile Gln Gln  Tyr Ile Tyr Lys Gln  Glu Pro Val 
    1265                 1270                 1275             


Gln Lys  Cys Pro Gly Arg Arg  Pro Ala Leu Asn Tyr  Pro Val Tyr 
    1280                 1285                 1290             


Gly Glu  Thr Thr Gln Val Arg  Arg Arg Arg Phe Glu  Arg Ala Ile 
    1295                 1300                 1305             


Gly Pro  Ser Gln Thr His Thr  Ile Arg Ile Gln Tyr  Ser Pro Ala 
    1310                 1315                 1320             


Arg Leu  Ala Tyr Gln Asp Lys  Gly Val Leu His Asn  Glu Val Lys 
    1325                 1330                 1335             


Val Ser  Ile Leu Trp Arg Gly  Leu Pro Asn Val Val  Thr Ser Ala 
    1340                 1345                 1350             


Ile Ser  Leu Pro Asn Ile Arg  Lys Pro Asp Gly Tyr  Asp Tyr Tyr 
    1355                 1360                 1365             


Ala Phe  Ser Lys Asp Gln Tyr  Tyr Asn Ile Asp Val  Pro Ser Arg 
    1370                 1375                 1380             


Thr Ala  Arg Ala Ile Thr Thr  Arg Ser Gly Gln Thr  Leu Ser Lys 
    1385                 1390                 1395             


Val Trp  Tyr Asn Cys Pro 
    1400                 


<210>  3
<211>  13649
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Epx human gene

<400>  3
gcaccttgga gggagtgagt agggctaggg gataaggaga ggggccaaat cattcatcac       60

agatcattca ttcactcaac aaacacctgc taagcacata ctaaatgctg ggctttgagc      120

tgggtatggg gggtgtgtat aacagtaagg cagattcagt ttctgccctg ttgcaggagg      180

agaggcaccc ttccaatcat ctggcccaac tctcattcta gggatgtgaa aactgaggcc      240

tggagaggga aagtggcttg cccaaggcca tgcagccagg cggtggcgac tgaggtgcac      300

cgctcctgtc agccaacaaa tatccattga gcgacacctg tgtcccaggt gctgctctgg      360

gccctgggag aagtgcatca gtgggcttgg tagtagaggg tagggatgga gtgaagggta      420

ggcaggaaga atgtccccag gctggtagga ggtggggtgg ggggtttcag tctcaaaact      480

cccatgaaaa ccagagagaa gtttcagaac tccacccaag aggctgggtt tctagggccc      540

agagctgccc tcccccaccc tagaatgggc tataaaagtc ccttcccagc tacgtccaga      600

gaagagctgg aggaagtgag aggtcggctg ggggtcctca aagtgagagg ggagcagagg      660

atcctcccgt gcaggctgtg gatgtcactc acttcccagc tggtgaagcc tcgctgcaga      720

gatgcatctg ctcccagccc tggcaggggt cctggccaca ctcgtcctcg cccagccctg      780

tgagggcact gacccaggta atagtcccct agacaggcaa ggaggaggga ggggaaatgg      840

aaggggaagc acttgggtct tggagggggt cttgtggctt gctgaaccct gagtccccat      900

ctctttgaac agcctcccct ggggcagtgg agacctcggt cctgcgagac tgcatagcag      960

aggccaagtt gctggtggat gctgcctaca attggaccca gaagaggtgg acttgggtct     1020

gggggctgca tgggcctggg aggatcagtg aggggcatgg gccccagcca agttcatctc     1080

actcatcagc cacctctgga ccccatgaac atttcctgtt ggtagagcct cccttccatc     1140

catccttctg tccgcttgcc ctgtcctgac tgtgccccag gactgggtct ctgctgggtg     1200

ggtctgcacc ctctctccag ccctcactcc tcctctcctg ggcagcatca agcagcggct     1260

tcgcagcggt tcagccagcc ccatggacct cctgtcctac ttcaaacaac cggtagcagc     1320

caccaggaca gttgttcggg ccgcagatta tatgcatgtg gctttggggc tgcttgaaga     1380

gaagttacaa ccccagcggt ccggaccctt caatgtcact ggtactctga tccccactga     1440

gcccgctggg cctaccctgg cctggagtag aaggaatcca ggagagggag gcagggtgca     1500

caggtttggg gtgctgggag gagagagggt aaagggatgg gaggtacaga gcaggccagc     1560

tcaggtctgc ccatttgcct tcccacagat gtgctaacag aaccacagct gcggctgctg     1620

tcccaggcca gtggctgtgc tctccgggac caggccgagc gctgcagcga caagtaccgc     1680

accatcactg gacggtgcaa caacaagtgc gtgcggggcg gcaggagggg ctgcccctgc     1740

ctgggggacc tctcccttcc tgcacccacc ctctccctcc atgctgagcc atctccaggc     1800

cctgccccct gctaacctat cccacccatg gctgcaggag gagacccttg ctaggggcct     1860

ccaaccaggc tctggctcgc tggctgcccg ccgagtatga ggatgggctg tcgctcccct     1920

tcggctggac ccccagcagg aggcgcaatg gcttccttct ccctcttgtg agttggggct     1980

gagggtttgg gaggttgctt gatctcttaa atgcggggag taaaacacag cccagagtca     2040

cgcaggcagg gcttgaaccc aggcccttcc actgaccagt gcagtgactt gaggcaaata     2100

acacagcttt ctgaggctta gtttcctcat ctgtaaaatg gccctaaaac ctacctcgta     2160

gagcctgtgt ggatattgaa gtccttggta taaatagcta tagaggacat gatctattca     2220

tgctaaccat tacggtgttg tacggttttt tctgagaaaa ttagtgtcaa agtcttgcta     2280

aatataaaca gctctatacc ttaatctggc tttatctatt gatctatttc acatttatca     2340

actcatcagt tttctattga tatatcgata gagcagtcta tcatctaccc atctatcaac     2400

atctattaat taattttctt ctatccaccc ttccatctgc tgaccccgta ctccctacgt     2460

gtattatcca tcacctggca accagcccat gcacctgtga atccgtgcta tcatctggtt     2520

agctatcagt gtacaaattg atctatctat ttgatctccc ttcccctctg ggagagctgg     2580

tgaggtctga gccagtcaac ctagcccctc tccttctctt taccaccgga atcctcagga     2640

gcccagccag aaaccatcct tctaggaatg agagcaggag gtggctacgc ctccagggac     2700

aaaaggggca tggagggcag aagaggagag gctgtcaatt ccagcagggg agctgctgct     2760

ccctgagtcc tgggttggct ctaatacctt gtggggtcag ggagcccatg tcccgtgctg     2820

atgttatttc cccaccaggt ccgggctgtc tccaaccaga ttgtgcgctt ccccaatgag     2880

agactgacct ccgaccgtgg ccgagccctc atgttcatgc agtggggcca gttcattgac     2940

catgacctgg acttctcccc ggagtccccg gccagagtgg ccttcactgc aggcgttgac     3000

tgtgagagga cctgcgccca gctgcccccc tgctttccca tcaaggtacc taccctcagc     3060

caatctccca tgcccttgtg tggcctcccc caaaggcaag gtgctggggg tggggatctg     3120

gaagactgga gcaccatcct taaggagctg cctgtggagc tagggtatga gacagagaca     3180

caagaaacac agctgagcag agaccccgcg ccgtgtgtgt ttgagaggtg ggggtagggc     3240

aatctgccag gaggctcagg tcaggcttca tggagtggga agcccttgac acatgccttg     3300

acccatgggt ctgaatccaa caggggaagc ctctgggccc ctgcttttgg caacctaagg     3360

gcctcttagc tcttgccctt ctctccttcc cagagtagtc caagggtcct gcggctcttg     3420

ccagcttctt gggcttgggc tgtaagtagg gtcctaacct tcaggctaga agccaaggac     3480

agtgtggggc actaggggag gaaagataga atccagggag cagagtctct gctaggaaca     3540

tagggttgac acacgtgcac acacacactc tctcacacac acacacgtgc acacacacgc     3600

tccctctcac acacacatgt acacacacag tcacccttaa taggtggggc cacattcatg     3660

agggatgaca tgtgagggcc tctggatggc ctctccctgt tgcaacctta tctattcctc     3720

aatccctggc ttaggggcac ctcctctggg gagccttctc agatcttcct attacacttt     3780

taacatatgt cctcccctcc cctctcctct ctctccttcc ttccttcttc cttcctcttt     3840

ctttctttct tctttctttc ctttccttcc ttccttccct tccttccttc atttccttcc     3900

ttcctttctt tctttctttt tctttctttt tctttcttcc gtcctttctt tctttatctt     3960

tccttctttc tttcttcttt attattatta ttattgtttt gagacagaat ctcactctgt     4020

tgtccagact ggagtacaga ggggcaatct cagctcactg caacctctgc ctcctgggtt     4080

caagcagttc tcatgcctca gcctcccgag tagctgggat tacaggcatg tgccaacaag     4140

cctggctaat ttttgtattt ttagtagaga ttgggtttca ccatgttgac aaggctgatc     4200

tcaaacttct ggcctcatgt aatccacctg cctcggcctc ccaaagtgct aggattatag     4260

gcgtgagcca ccacacctgg cccacatatg gcttttctat caagcacagc agatgccact     4320

tcaacttagt ttcttaactc tatgtgtgtg tgtctttttc cactgaactg ccagcttcct     4380

gcaacctttc ctgtgttttt ttaaccttca taatctccaa agcagcaagc aagaaagggg     4440

cttagaaaag gtctgtcgaa ttgaacagaa ttaaagaagc tcaggcctaa gagtcaagag     4500

aactaagttc taatcccacc tttcctgcta actggttgtc acttcccctc tctgaggctg     4560

ttttccttgc tgtaaaatga ggatcgagat tgtttcaaaa gcctcattca ttcctaacct     4620

tttgagactc tatgaaacaa aatgttaagg acactcagac tgacggggtg agcagcatga     4680

gcctgggtga gtcaaggagg gcttcctgga ggaagggagt tttaagcaag gttttgagga     4740

ggtggaagat gacggagagg agtgagtctg ctattgaggg ggccccatgt cactgtctcc     4800

tcttccatct cagatcccac ccaatgaccc ccgcatcaag aaccagcgtg actgcatccc     4860

tttcttccgc tcggcaccct catgccccca aaacaagaac agagtccgca accagatcaa     4920

cgcgctcacc tcctttgtgg acgccagcat ggtgtatggc agtgaggtct ccctctcgct     4980

gcggctccgc aaccggacca actacctggg gctgctggcc atcaaccagc gctttcaaga     5040

caacggccgg gccctgctgc ccttcgacaa cctgcacgat gacccctgtc tcctcaccaa     5100

ccgctcggcg cgcatcccct gcttcctggc aggtcagaca gggaggaagg tggtgtcttc     5160

ccaggaaaca gccatccctg gggtcccaac tgggaagcaa tggtgggatg tggtgaaggt     5220

acatggtttg ggacctcagt attaggcaca ccataagcat ggatctgtgc acagccatca     5280

tagaatcaga acgttgagtc cctttgcaag ctccctgtgt gtggccagag ataactgctt     5340

aaccgtctcc agtgacaagg ctctcaccgc ctctatggca ccccagctca gccacaggca     5400

gctccgactg ttagaaagtc tccttatttt gatcacatat tcacctattc cccttaatca     5460

tgcttctgga acctcagaaa agacactgtc cctcttacac gcaggaatac ctcaaagtag     5520

ctgttaactc catctccatt ttttttctct tctctgggat aaatttccgt agttcctccc     5580

tgtccccagc tgttgctaga cagttaatac cctcttctgg aagcataatt tgaactttcc     5640

tcagggtctt ttgtcccatg tacatggtta caataataat ggtagtcatt tctcattaag     5700

atatttatct tattattatt attattttaa gatggagtct cactctgtcg cccaggctgg     5760

agtgcagtgg cgtgatctca gctcactgcc acctctgcct cctgggttca agtgattccc     5820

ctgcctcagc ctcccgagta gctggaatta caggtgcctg ccaccacgtt tggctaattt     5880

ttgtatattt agtggagata gagtttcacc atgttggcca ggctggtctc gaactcctga     5940

cctcaggtga ttcacctgcc ttggcctccc aaagtgttgg gattacaggt gtgagccacc     6000

acgcccaacc ttatcaagat atttaaatgt gccatctcta aaccttgcaa cagccctgaa     6060

aggagggaat tattattgtt ctcattttac gataagaaac tgagactcag ggaaagtgaa     6120

tcatgcgccc aagagcacag agttagtttc aaatgacaga gtccacttga gaacacagtc     6180

agtgtagtat caaggtctct gcccagtcca ctgtattcca ctgttttcct cacagagagt     6240

cggccccaac ccctcttttg aaggattgta catttgtgtg tcctggaaag agcagcttgt     6300

gccttcggga gaggtcaact gaactaagac cttgtgcaaa agggtttagt taaaaccaag     6360

caaatgatgg aattaacttt ctttccctgc ctgtagtagg tctgttcgta aggacagtct     6420

ctgcccaacc ctccctctct tcctctttcc ctctggttca cgggggagag cagtattata     6480

ccaagcccaa agataggaag aggtacacca gcccttggca gagaacacgc aggcagatgc     6540

agctcatgga caggtgggct ctcagtccca aagtcaaggt gcccttgccc atagctggtc     6600

caggctatgg atctggttgt cttgtagagt agaatcctta ggcaaagatg cccctgcctg     6660

agaccagcag ctgccctgtg ctttcccacc tcacccaagc ctgctaggaa cccccggtcc     6720

ttccgctcct ggcctgtggt gttagggagg agggtggcga tgaggagcct cagcacagct     6780

gaagagatgg aggtccagtg agggccagga gtttggccca ccccgtctct cccatcccca     6840

gccctgggtc taccctggta gaaagacatt tctctgggaa aggctgcagt aaatctgagc     6900

ttggggtttt caaggtgaca cccgatcaac ggaaaccccc aaactggcag ccatgcacac     6960

cctctttatg cgagagcaca accggctggc caccgagctg agacgcctga atccccggtg     7020

gaatggagac aaactgtaca atgaggctcg gaagatcatg ggggccatgg tccaggtaag     7080

gagctctgca tcccagcatc ccccagatga caagcttggc atgagaagca gtccttaaca     7140

catccttgcg gatgtgccta aaaccagctg ggtctgggca actggcggag cacctggacc     7200

tgtcctctgg ccccgattct gcctctaact cccgtgtgac cctgtctgtg tcactcaccc     7260

tctctgggct ttgtatctcc acccaccaat agtaaattaa tgttgtcaca tttgacgtga     7320

tgacaataaa gaatatgtct gagccaccct ttgaaaaggc aagggtatgg gtgagtagcc     7380

tctggggaat gttcctcctg tcttcccttc cagatcatca cctaccgaga ctttctgccc     7440

ctggttctgg gcaaggcccg ggccaggaga accctggggc actacagggg gtactgctcc     7500

aatgtggacc cacgggtggc caatgtcttc accctggcct tccgctttgg ccacacaatg     7560

ctccagccct tcatgttccg cttggacagt cagtaccggg cctccgcacc caactcgcat     7620

gtcccactta gctctgcctt ctttgccagc tggcggatcg tgtatgaagg tgaccaggtt     7680

ttccaggggg caaatggggg tgagggtggg gagcatgccc tcccctaggt gggccaagct     7740

tactgccagg aagccaggct gctgcagagg ccactgctaa tatctcccca ggacagtgga     7800

aacaaggcag gtgccagcaa gaccctcagt cacgggcctc ccatcctgtg tggaatgaga     7860

ggatttttta aaggggtgga gactaatgtc agattgatgg ggagctcacc ttccattcct     7920

taagaagtac ctcccagctc cagctgcttc atgtctctcc agaactctgt ttcctgacaa     7980

acgttactaa catacccgac tggcttgtcc agctctgggc tagcttggca tcatgtgata     8040

acccaagtag cttcccagag gctggtccaa tctgtgctgc tcacattccc tgccaccagg     8100

gggcatcgac cccatcctcc ggggcctcat ggccacccct gccaagctga accgtcagga     8160

tgccatgtta gtggatgagc tccgggaccg gctgtttcgg caagtgagga ggattgggct     8220

ggacctggca gctctcaaca tgcaacgaag ccgggaccac ggccttccag gtgagggggc     8280

tgtccacctc ttctcccagc tttgctcggg ccaggctgct caaggggttc tgggaagacc     8340

ctggtacctc ctttctgact gggactgtct acaggatgtg caggagtgca gaggcatgca     8400

aggccaaggt cgatgtccca aagcactcct ggaacaccgc ttgctgtcct gccatggctc     8460

ccccatccac tgtaggggct ccagctttag gttcaccaca ggaccagcac ttaggctcag     8520

gagctgaaaa agggaggctc gaactttcca agtagaaaaa aagcaatagg cttaaaaggc     8580

agggaagaac tgctccattc ccaacacgct ggcaagttcc aaggaggaag gctaaaattc     8640

cagagctaca gaaacgctcc ttgctctaag tggagaaagg caaagagcct tagaggcagg     8700

gaataggtgg aataaaacta aggctgcagt ggctgtttgg tgagggcaca aatgacttta     8760

tcccaggaaa gaagaaaata taggcacttt gttagtcact ttcatgtata ttaatttatt     8820

ttgttctccc aatcaccttg agaagcaaat gattacagcc attttataga tgagaaacta     8880

tgttcagaga cagctagtaa tttgcccaag atcacataaa taagaagtag taaaatctga     8940

atttaaattt acaatttctc ctttcttccc cctgttcaac cccagtaggg gaaggttttg     9000

gccactgcct tgctcctctc tccttcccac ctcctacctc cctgtctaga aagaacctga     9060

aggcccatct gcccatgtat gaagcagtgg tggcacctcc tactgcccac cccacttcac     9120

acagcgcctg gtagagcaca gcaggcactc cggaaacctg agcttctttc ctttcttaaa     9180

cttgggcgct cctggcagct aaggagctgt gggcaccccc tgccggagag ctgagatcgc     9240

tagccaccca agtttctatt aggttttgaa gggaaggcaa gggttaagga aagacacaaa     9300

gagagagggc ggctgaacag ccaatgcagg tatttatttc cagcataaaa cctacagagg     9360

tgggggacca gcttattgcc agaacctgcc gccgcctaca gctggggtac tgggtatggg     9420

tatgggtatg ggcaggaggg gtctgggtcg tatggcttgc tacccagcag gatattgata     9480

agatgtacct atgatcaggt ccttttttca gtgggatgtg gtaagatgtt ccttggacct     9540

ttgcccagca ggatatgata gggatgttcc ttcagttggg cctttgccca ttagggtatg     9600

ttatgttttt catggcccga cctcctgtgg aacgtttcac tttgaccaag gtctgggaaa     9660

tggtgggggg cttagaaaat ggtgcagttt ggactaacat tcttgccttc tactttggta     9720

taaaaggaag agctggagag ctgagatcgc tagccaccca agtttccaca ttgcgagctt     9780

ctgctccccg caatacctgt gccctccaga aatattatcc tgacactagc tcttgcaatc     9840

tcctctaatc ccttcccaag tccaacatca aactgggaac tggacaacct ggtttgagct     9900

ccacttaaca gtaaagtgac cctgaagcct atggttgctc aactttagta aacataccag     9960

atatagttag catgccataa aagcacctca aaaaggtgct gtgagggtcc tgagatattc    10020

acccaatagt gctcagtaat ggtaaaatac tgtgtggttt tcatgggttc cgctggggga    10080

tggtgtgtgt gagctgtagt tcaatggatg acgttgggct ggtgtccctt cgggacatgg    10140

caaagctatc tcctaccttg attgtcacat cttatgatgt ggcttggccc tgcgtgggat    10200

cctgatggct gacaaattgg tatggcttgt ctttggaagt ttctgaaaac tttttaaaaa    10260

cttctttatt gagatatacc ataaaattca cccatatgaa atagacaatt caatgatttt    10320

agtgtattta gagttatgca cccatcacca tgatctaata tcacaccatt ttcactcccc    10380

aaagaaacct tgtaagaaca gtcaatcccc atccccaccc cagccccaat cacctctaat    10440

atactttgtg tctctatatt gacctatgca ggacctctca tatcaacaga atcatagtgt    10500

gccgtccttt tctgagtaga tgaattttat cattgctctc catttgtttg cttgttcatt    10560

catttattca tttgctcact cattcattct acaaacctga tggagagtct tttatattct    10620

gggtactgtc ttacttgtgt ctaatgaatg cagtcgagcc cagtaatatc actaagtgtc    10680

ggatttgtgg ttatgagttt tgggttaaaa cagcttttta ggttaggaca cactcctcag    10740

tctgatgcac actgagcaca gttgtccact cacattttca atcagaggac agaaacctag    10800

tctttggaag ctctagggac tcttctgcca gcaggatctt ctggttctgc ccaatattga    10860

ctggccacag cttcccccca gaggactggt ggagaaaaac agaagctaat gggagatcag    10920

caagactgaa gctgcttctc cccgttcccc tgcagggtac aatgcttgga ggcgcttctg    10980

tgggctctcc cagccccgga atttggcaca gcttagccgg gtgctgaaaa accaggactt    11040

ggcaaggaag ttcctgaatt tgtatggaac acctgacaac attgacatct ggattggggc    11100

catcgctgag cctcttttgc cgggggctcg agtggggcct cttctggctt gtctgttcga    11160

gaaccagttc agaagagccc gagacggaga caggtaagtg accctatcat aaaagacatc    11220

agcaccagag gcagagcaga aaaacactag catttcaaga ctaaacattg aagaacactg    11280

ctctttttag tatcatttct tccaagttca caggatctga aatcaggagg ctcctctctg    11340

aaaagctggg tcaaaggaag agagacactg acccaggcaa ggcccatatt gcctgagctg    11400

gagtcatctt aaacccagag gttgcctggc agcctcacta ttctgggttg gtggatccca    11460

gaaaacatgg gcagaaaggg ctaaatctgg tttccctcca atacatttgt gatttaagac    11520

ctgacggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg    11580

gcggatcacg aggtcaggag atcgagacca tcccggctaa aacggtgaaa ccccgtctct    11640

actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcc cggctacttg    11700

ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt gagccgagat    11760

cctgccactg cactccagcc tgggcgacag agcgagactc cgtctcaaaa aaaaaaaaaa    11820

aaaaaaaaaa aaaaaaaaaa aaaaagacct gtctccttat ttggagttgg tattgcccga    11880

gttcaaatcc agccctggcc acttaaatta ctgtgcactt aatactgggc aatttatttg    11940

gccactgaat ttgtttcatt tctgagattc caatcttgca ggaattttgt gagaattgaa    12000

tggaataata tatgtaaagt acctggcaca caacaggtgc tcattataag gtaattcctc    12060

cccagccttc acccacatct ctcgactgcc tggtaggttc tggtggcaga aacgaggtgt    12120

tttcaccaaa agacagcgca aggccctgag cagaatttcc ttgtctcgaa ttatatgtga    12180

caataccggt atcaccacgg tttcaaggga catcttcaga gccaacatct accctcgggg    12240

ctttgtgaac tgcagccgta tccccaggtt gaacctatca gcctggcgag ggacatgagg    12300

cttctgcagg taaggggagg ccacctccag caccctgggc tgggttaagc cctcacatcc    12360

ttccctggat ggatggctga gtcctcttag gtctctaagc agagaaaaca gaacttgtca    12420

ctaggtactc tttccaagtg gcttcccaat gtgctagttt ctgggctgac agtcaattcc    12480

aggccctagg actttggggg gaaattagga gcatccaact atcctcagct tggtcactaa    12540

tacctgaaaa cagctccatt tctaaacatc cagtaaattc ctgacttatc cagttctgtt    12600

acttccacag gagtctatcc caagtctcca acttttggag acaaggggaa ggggaggacc    12660

atgaggctgc cttgtctccc tggagcaagt gcaggctgct gacgcttctg ctggctacag    12720

ctcagagctg ggttccccag ccaggagtga aggctggggg ctcctatcag caatggacct    12780

tcccgccttg ggagcctctt aggtattagg ctatgaatca gcgccacgtg caaaggcttg    12840

ggagccaagc catgtggtct tgcaccccag gcaagaaaag tcagctggag ggtttacagc    12900

actttctact gtttcccagc cctccctccc ctccctcacc atgactaaga gaccactcgg    12960

tcctagcctc cagacacccc acaatactcc tctgagcctg aggccaggca gcatgctctg    13020

cttctaccaa taaagcactg ctaagggcag gggctgctgt ttctgtgttg ggctagggaa    13080

gacgtggcct cagttccatg ctttgctcca gatgtttaag agaagtgctg ttaacacgca    13140

agctggcaca accatctaag cctctcctgg gggctgaatt aggagagccc aaagaaacac    13200

tgtggagtag ggaaaggcag aaaaggggaa gggcagacat ggtaggggcc ccgacattaa    13260

gaacacccta gccataccag caacctgagc agacaaacag ccaacagaac atcagtcaaa    13320

ataaaagggg tttatgtaac aaaaaacaaa aaaacaaaca aacaaaaaaa cacagtaaaa    13380

gataccaccc agctagcaga aaggactcag cactgccttc agccttcact tactcagaaa    13440

taactcatat ctcaacctca gcaagcccca agcagtagaa tgaggcttcc ctggaaagag    13500

gctgagactc acaggctggg gatttaagac cctctcaccg tccaccttcc ttccttcttt    13560

ggtcttggaa gatgaaaggc tccattttta aagggtggag aacagcagat cccctgctac    13620

tgtgagacaa gccagaaaag tgagtcaag                                      13649


<210>  4
<211>  715
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated EPX protein (amino acid change Q122->H)

<400>  4

Met His Leu Leu Pro Ala Leu Ala Gly Val Leu Ala Thr Leu Val Leu 
1               5                   10                  15      


Ala Gln Pro Cys Glu Gly Thr Asp Pro Ala Ser Pro Gly Ala Val Glu 
            20                  25                  30          


Thr Ser Val Leu Arg Asp Cys Ile Ala Glu Ala Lys Leu Leu Val Asp 
        35                  40                  45              


Ala Ala Tyr Asn Trp Thr Gln Lys Ser Ile Lys Gln Arg Leu Arg Ser 
    50                  55                  60                  


Gly Ser Ala Ser Pro Met Asp Leu Leu Ser Tyr Phe Lys Gln Pro Val 
65                  70                  75                  80  


Ala Ala Thr Arg Thr Val Val Arg Ala Ala Asp Tyr Met His Val Ala 
                85                  90                  95      


Leu Gly Leu Leu Glu Glu Lys Leu Gln Pro Gln Arg Ser Gly Pro Phe 
            100                 105                 110         


Asn Val Thr Asp Val Leu Thr Glu Pro His Leu Arg Leu Leu Ser Gln 
        115                 120                 125             


Ala Ser Gly Cys Ala Leu Arg Asp Gln Ala Glu Arg Cys Ser Asp Lys 
    130                 135                 140                 


Tyr Arg Thr Ile Thr Gly Arg Cys Asn Asn Lys Arg Arg Pro Leu Leu 
145                 150                 155                 160 


Gly Ala Ser Asn Gln Ala Leu Ala Arg Trp Leu Pro Ala Glu Tyr Glu 
                165                 170                 175     


Asp Gly Leu Ser Leu Pro Phe Gly Trp Thr Pro Ser Arg Arg Arg Asn 
            180                 185                 190         


Gly Phe Leu Leu Pro Leu Val Arg Ala Val Ser Asn Gln Ile Val Arg 
        195                 200                 205             


Phe Pro Asn Glu Arg Leu Thr Ser Asp Arg Gly Arg Ala Leu Met Phe 
    210                 215                 220                 


Met Gln Trp Gly Gln Phe Ile Asp His Asp Leu Asp Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Pro Ala Arg Val Ala Phe Thr Ala Gly Val Asp Cys Glu Arg Thr 
                245                 250                 255     


Cys Ala Gln Leu Pro Pro Cys Phe Pro Ile Lys Ile Pro Pro Asn Asp 
            260                 265                 270         


Pro Arg Ile Lys Asn Gln Arg Asp Cys Ile Pro Phe Phe Arg Ser Ala 
        275                 280                 285             


Pro Ser Cys Pro Gln Asn Lys Asn Arg Val Arg Asn Gln Ile Asn Ala 
    290                 295                 300                 


Leu Thr Ser Phe Val Asp Ala Ser Met Val Tyr Gly Ser Glu Val Ser 
305                 310                 315                 320 


Leu Ser Leu Arg Leu Arg Asn Arg Thr Asn Tyr Leu Gly Leu Leu Ala 
                325                 330                 335     


Ile Asn Gln Arg Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp 
            340                 345                 350         


Asn Leu His Asp Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile 
        355                 360                 365             


Pro Cys Phe Leu Ala Gly Asp Thr Arg Ser Thr Glu Thr Pro Lys Leu 
    370                 375                 380                 


Ala Ala Met His Thr Leu Phe Met Arg Glu His Asn Arg Leu Ala Thr 
385                 390                 395                 400 


Glu Leu Arg Arg Leu Asn Pro Arg Trp Asn Gly Asp Lys Leu Tyr Asn 
                405                 410                 415     


Glu Ala Arg Lys Ile Met Gly Ala Met Val Gln Ile Ile Thr Tyr Arg 
            420                 425                 430         


Asp Phe Leu Pro Leu Val Leu Gly Lys Ala Arg Ala Arg Arg Thr Leu 
        435                 440                 445             


Gly His Tyr Arg Gly Tyr Cys Ser Asn Val Asp Pro Arg Val Ala Asn 
    450                 455                 460                 


Val Phe Thr Leu Ala Phe Arg Phe Gly His Thr Met Leu Gln Pro Phe 
465                 470                 475                 480 


Met Phe Arg Leu Asp Ser Gln Tyr Arg Ala Ser Ala Pro Asn Ser His 
                485                 490                 495     


Val Pro Leu Ser Ser Ala Phe Phe Ala Ser Trp Arg Ile Val Tyr Glu 
            500                 505                 510         


Gly Gly Ile Asp Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys 
        515                 520                 525             


Leu Asn Arg Gln Asp Ala Met Leu Val Asp Glu Leu Arg Asp Arg Leu 
    530                 535                 540                 


Phe Arg Gln Val Arg Arg Ile Gly Leu Asp Leu Ala Ala Leu Asn Met 
545                 550                 555                 560 


Gln Arg Ser Arg Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg 
                565                 570                 575     


Phe Cys Gly Leu Ser Gln Pro Arg Asn Leu Ala Gln Leu Ser Arg Val 
            580                 585                 590         


Leu Lys Asn Gln Asp Leu Ala Arg Lys Phe Leu Asn Leu Tyr Gly Thr 
        595                 600                 605             


Pro Asp Asn Ile Asp Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Leu 
    610                 615                 620                 


Pro Gly Ala Arg Val Gly Pro Leu Leu Ala Cys Leu Phe Glu Asn Gln 
625                 630                 635                 640 


Phe Arg Arg Ala Arg Asp Gly Asp Arg Phe Trp Trp Gln Lys Arg Gly 
                645                 650                 655     


Val Phe Thr Lys Arg Gln Arg Lys Ala Leu Ser Arg Ile Ser Leu Ser 
            660                 665                 670         


Arg Ile Ile Cys Asp Asn Thr Gly Ile Thr Thr Val Ser Arg Asp Ile 
        675                 680                 685             


Phe Arg Ala Asn Ile Tyr Pro Arg Gly Phe Val Asn Cys Ser Arg Ile 
    690                 695                 700                 


Pro Arg Leu Asn Leu Ser Ala Trp Arg Gly Thr 
705                 710                 715 


<210>  5
<211>  28057
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PON1 human gene

<400>  5
gaagacgttt tgtcctgttc tgtagcatct agaacagcgc ctggcacata gtaggtactc       60

aataaatgcc agctgcatga ggaaatgaat gagctgtgtg ggggatgtac ttgagtgaac      120

tctaaagtca gagtggtgtt gagagaaaaa tgcttgaaat ccagatgttg gaaggtgaca      180

cagagtagta gcctggtgag aacagttaga tcttaggggt tcctactaca gccctccctt      240

ccgcaccttt ttggctgtca ccatgatcaa gctactgaat ctctctgaga cgcaaggacc      300

gggatggcac aaagtgagtg ctcaccaaag cttgactgtc ctttcccatg gcaatttact      360

tcagcttgtt tgatttcccc tccccgactg gactaggcac ctattctctg tcttctctct      420

ttacagttgg aaggagcaaa atgggacttt tggctgaaag tgctgagctc ctgcggtggg      480

ggctgaccgc aagccacgcc ttctgtgcac ctggtcggcc cagctagctg ccgacccggc      540

ggggaggggc ggggcgggcc aatcggcgct gccccagcag ggctgcggct gcaggcaggc      600

agagcctcct agcccgtcgg tgtctgcgcc catcgatccc tttgtctatc cccgaccatg      660

gcgaagctga ttgcgctcac cctcttgggg atgggactgg cactcttcag gaaccaccag      720

tcttcttacc agtaagttgg gttgtggtga gggctgcagc cttcgtcctc ctcactccct      780

gccagctcca cgagccccca gaaagttggg tccaggctgt taacagaaca tttacaagca      840

ggtgctagat gcacactctg cgggggtttc ataaatgttt gtccagccgt catgtgtcac      900

ttgaaaacaa actcttgctc atggcctgag acatgggata aggaggcaat tgccaggggt      960

gtgagtgccc aggttgtcag catacacgaa ttaatttttc atgaagattt gtgtgccctg     1020

gctacagatt cacttctcaa cctggaaaga aacaaactaa cctggctggg ggttctcctg     1080

atattttgtg tattagagaa aggagcccct gtcgcttctg cgccttgact gcctggccat     1140

ggcaaacctt ccaggcttga agattctcaa attgaggcta ctgagggcca cagcaaaact     1200

gcgtgtggac ccgagcaggt ggagctaacg tgtgctgtga tggttcgctt cagtgggggc     1260

aggcggggaa gagggaaccc tggagccagc atctgatgtc ctggggttta gctctgcccc     1320

atgagtatgc gatttgggca aatcacttta catctctaac cttagctgct tcagtaaact     1380

ggaaatagta atacacactg cctgcgacag agtagctatt caataaatgt tagttccctg     1440

cttcccttta aagtatttaa taaagggtta agtgctatac aaggggggtg gggatatttt     1500

aagaatgtat caaaagtttc ataactttta acaggagttc aaagtctaca gatcatccta     1560

gtctctaagg cttagtcaac aatgccttat ttactttaaa gtaaaaccta ataaaaatta     1620

aatataaaaa aattatatga gcttatggac taattagaag cttacattca gaatgggttt     1680

ttactattta ttgtggatgt ttttctaatt tttttaagtt acagagtgca gaaaaaaagt     1740

aagaagcagt tggtattctt ggcttttaaa tcatgtaaaa attacagttt gtgagttttt     1800

attaatcaca gtgctggtgg ctgccaaagg agattatagg tatagataaa aatatataga     1860

taaaggatgg gttgctgagc ctcctggagt gacccagaca gaggaaggaa gggaaatttt     1920

acccactgtt ggaaacccct aaaacctagc tactcaactg ggtctgggga ccagatgcct     1980

gagcatcacc taggggctcc ctgtacaggc agaatctcaa gccctacccc acactattga     2040

atcagaacca gcgtcatgga acaaactccc tgggggatta gagatcatga atctgcccca     2100

gggagagaag gcaagagatg atatcatgag gcctgcatca ggagcaagcc aaatccccag     2160

gatagatgca tccttttttc ttcagacttg gagtgtatgt gtgtgcggct cacaggaagc     2220

tatatatgcc tgggctggag ggaacttaag gaagcacaca agggatgcct caagagattt     2280

ctgagtttcc caggtgggag cagtacagag aaaagaactg agagagttcc cctagaccac     2340

gagtctccca cccacgagtc tcccaccttt gtagtcggct gtatgtgccg cacaagtcca     2400

gggaatgcct tggatgatgg tagaaacagc tcccctcccc taccccaact tgggctatgg     2460

aatgttgcag catctgtatg gcaacttcct tgtccctaca ttgctaattg caatacgtga     2520

gtccactgag tttcccttct cagaaggaaa ccacaaagct aacgttgggc ctctcgatgc     2580

atttctgcca ttccatgctt actgtaggca acacacagtt gtgggaagag agtagttgtg     2640

gattcctgat gacctgggtt agatatcatt tctgcaactt tcaagttatt ttaccacttt     2700

attccagaaa agttccagcc agtttctcca cccgaaaatt aggggataat aatacatatt     2760

acagcatata tatatatata tacacacaca cacacacaca catacatata tttatattta     2820

tataaaacat ataaataaaa ctaagtatat atatatatat aaaaatcagg catatagcag     2880

atgtcctgta aacgttagct tttatagctg tcatatgtga tctcaaaaat atagagtgat     2940

acttgaatat gtattataat catacttcat tgaaagtctg agataaggac aaataatcct     3000

ccaaccctcc agtctcccct atgaatgcaa ccaacaccat cttctcagtc tgatgtactt     3060

gcctagtatc tccacaaaac acttcagtgg acatctgcag agtaccttct ctttgcaaac     3120

gttgtgtttc tgctggaggt tataggaatg aataggttgc agtattcact caccaatttt     3180

aaagtctact gggagcaaaa gaacaaaaac tgacagctgt gaaactgaca actatgacaa     3240

ctatggtaag aaagttgaca gatgtatatg tgaaggttcc tgagggtaaa ctaaggagtt     3300

attaatccca atgcagaaga ctggagaagc tacaaagcat catgagtagg ggtctttcca     3360

gtgggtaatg ggctaaagag cattctaggt gaagggaaaa gtgtgagcaa ataaaaagag     3420

gtatgaaaga aatacaggga agagtcctta gtatcatgac acttgatttc aaatcccaac     3480

tctaccctct taaataagca accacatgca atttactcag cctctcagtg cctccatttc     3540

cttacctaca aaacagggta aatattcatc tttttctcaa aggtggctaa aaagattaaa     3600

tgaggaagta tgtgtgagag cccttattgg agcttggcac atagtaggcc atgaaaagca     3660

atttgaatga atgaggcgtg tgtagtagca gaaaatagac tgattagagt gaatttggcc     3720

ccaagaagag tttgagaatc gatacggatt tcttaatgcc taggcaaaga tctctgcttt     3780

tttctgcgag cagccagcat gtattttcac cgaatacttc tgccttggtt tggatgttcg     3840

tcctctccaa acctcgtatt tgatctctaa tgttggaggt ggggcccaat gggaggtgtt     3900

tgggtcatga agatggatcc ctcatgaata gattaatgac ctccttggga gtgagtgaat     3960

tctcactcta ttcatttcga gagagctggt tgattgaaaa gagcctggta cctctcccct     4020

ctcttacatt ctctctcatc ccatgatctc tgtgagtact ggcttctctt catcttctgc     4080

aatgagtgga agcagccaga gcccctcacc agatgcagat acccaatcct gaactttcta     4140

accatccaga atcataagcc aaataaacct tttttcttta tcagttgctt agcctcagat     4200

gttcctttag agtgacacaa agcagactca gacaagttca cagcaaaggc tgtatggttt     4260

ctgcgcagag ttcagagtct agtgaatcag agatatatct cagacattga cccttatctc     4320

ttaggcccag aacatttgga cttaagcctt tgacaagata tttcctaata aattgaaaat     4380

gaggtagaaa aaatatgagt tggatgataa taacacaggt gggtcaattt tcaggtgcat     4440

cttccagctt ttaagcagtg ttctctgtag attttgcctg gtcagagagc taaatgtgag     4500

ctttgtgttc atacttgaat tccaatccct gctcagccac tttataactc tgtggcctta     4560

gaaagccact taatcttggt caactataac ttagggaaaa taacacctca cggaggtgtt     4620

tgaggattaa acgcgggcat atacggtacc tgaactatag tagtaatgat tatcctgttg     4680

agatatgaca tgtttgggcc acaaattgga acccaaatca acaagtgctg acttaatgcc     4740

cccttgccca ccctgggctc cctttaactg tgattattct atgttttcca ggctagagat     4800

catcttctat gagagagaag cctgaattag aataggagct gaccagttct gcctttctcc     4860

atcttttgtg aacccatatg tttagtgacc cttgtgagtc aggcagcatg agtattcttc     4920

ccattggttt tgagtctaag aaaagtgaat ttgactatcc ttggtgtttt tcacaagtct     4980

tggcccattc agtgatttta tgtccttgaa tctctccttc catgccagtc tttgtgttgt     5040

cctcggttat gaccatcacc cttaacatct tgtacctgcc ctttggttcc ttgagggcat     5100

gctacaaata ttcactacac tttccctaga ccagagtttt ttcaaatggt gggtaacaaa     5160

gtcaatttag taaataatta ccaacattta aaaataaata aaacagaatt gaacagaaaa     5220

gttatgaatg tatgacacag attaggatga gtattgtttt gtgaagcttg attcagatgt     5280

gtatgtgtat gtgtgtgcat gtgctgggtg ttcgcaccat ataaaatact tttcctactg     5340

tgagtctctg tctgaaaagt ttgtaagcca ctgctttatc acttcccctt ttatttcctt     5400

attgtcaata tttgcaatta taatgtcaga ttttcatttt gaaaatacct ttccctttct     5460

taggttatgg gacagattcc aactttcctt tgaagcctgc tttctaagtt cacatctatc     5520

aatcaggaaa ccacagtctc ctcacagtcc aagccttcat catctattca ttcatctctg     5580

tatttctagt acctagactg gtggctcttt actctggtta tacgttggga caaactgtgg     5640

cacttttaca aagcagatta ttaagaggca ctccttgcct cttacgtcag atttttttag     5700

acagcgaaaa tgatagccag tggcctgatg gtaggaatgt actcattttt ttctgaatga     5760

ataaatgaaa gatcaatcac ccccaaattc ctatcatttt gtaccacgtc ggtaagaatt     5820

ttatctagcg tgtctgttcc gcctgtagcc catccgcctc ctgtgagttc aagtcatcag     5880

gaggacaagt aaatttctta gcctatctga agccaaataa gatttctagg gatatttgga     5940

taattgtcac tacttgctat gacaatactg tatcactagt tctctaaaaa aaaaaaaaaa     6000

agtttattgt ttaaatctct tggttgtgct aacgtcgtct gtttctttca aatgcagcat     6060

cagtagcttc gctctgctca ggcagccggc tggcacttcc ttctcacatc tgttcatttt     6120

tcctttgtcc tttactcaga cattttctat ggtgtttatg cactcatatc taataagtcg     6180

ctcctgtgta tgtgtgtgag tgcacctgtg tgtgtgaaat gcctttttac atgcaggcct     6240

tgtgtatgat tttctgaagt tacaaatcct ttcaacgtac ctgtattttt caagcactac     6300

atcacaaagc agatgcccag tccaggctgc ggagtcagat tgggcagatg agtaggaggc     6360

tgcccatctg tcagcaactc taaaacatca atggaataaa ctggaaccat gttgccattt     6420

acccggactt tccacctagg agtccttaca cactgatgaa attgctcctg ttcctgccaa     6480

agtacacaga gccctagaga ggatattatg tatctcttat gtgtacctat ccacctctgc     6540

taaataaaaa ctaaatattg tacccagagt tccccacttg tcttgccctg gccttgcctg     6600

gaaaaattgc aggaaaaact ctggagttga aactcaggca aagtacagtg aaggagaact     6660

tttgtggact gcctaccttt gcaacttatt ataatttctg aatagttttg tgtgtgtttt     6720

atttctttct cccccacaga acacgactta atgctctccg agaggtacaa cccgtagaac     6780

ttcctaactg taatttagtt aaaggaatcg gtatgtatgt gagaggaaga agggtctcat     6840

ttgaacttcc ggtatttttt tgctctttgt gtgattaatg tgcctgttca attctgtcca     6900

aaaataaaat tttgaatcag gagagtcagt ggtagttaat gataaatacc atgttgtttg     6960

acttttgact tcaccaacat actgccaagg tgttgggagt tttggttgtt tgtttttgtt     7020

tgatcaatag agcaaaaaaa aaaaaaagaa aaaaagaaaa aagaaaaata gaataatgtt     7080

tgattccatg gcaatctaac ctgaggagat ggcagaagag gggagggaga gccagataaa     7140

gcattgaata aaggtaactt ttttttagaa aggctctgac aggactttgc aattaccaca     7200

aggcttctcc ttatgcatct ctcttttgat attggacagg aaaatttttt ccagaagctc     7260

tcagcagatt tccccttaga tcttatttgt cagagctgga ggacaggctg gtgccctagt     7320

tgcaaaggat gctgggaaag taattatcaa gcctccaatg tgggaggcag gccctgtcag     7380

caaagataaa acggtaggag aatagcagct gggaggcaac caacaaggag agtccccggg     7440

ctcaactctc cagctggttc caaccaacca gctttgttat ttgaagacaa ttggtttgag     7500

atcatgcttt tgtgtgcttt gggtgtttct ttttctttct tttttttttt tttttttttg     7560

ttcttttaga attattcatc tcagttgatt aaggctcagg aggctagatc agatgactta     7620

gtaccactaa atttcactag atatcttatg gtgcgattgt tttctagaaa aatatgatat     7680

tgatatcaaa tatcactggg tttttgaaaa gcaaactttc cactaagtgt agaaatacct     7740

atcaaatagt tcatttttct ctagataaat tgaaatgtta aaaatttaca tgtacttaaa     7800

gtataactaa cttgaagaca gtaatattta accgatgttt ataattagta gtaaaaattc     7860

atattcttga tcacctaaaa tgtatcccca ttttaactca actatttgga atttgcttat     7920

atcttcaata tggctttcca agggtttaat tgatttggaa gtattaagta tcaacatata     7980

tttgtaattt accttgtatc tttagaaaac aagttctttt caaataatca tggcttttgt     8040

acgttttgtg aatttccatg aactttaaga ggattcagtc tttgaggaaa aagctctagt     8100

ccatcaattt aaaacaaata tactaagtgt aaattttaat taaacttgtt aatgaattaa     8160

tatattttta atttccatat aatcgcattc atcaatttga ataaatgaaa gaatgaatta     8220

ttctgaacct attaaagaag agtgatgtat agccccagtt tcaagtgagg tgtgataaag     8280

aaatggatcc acatcctgca ataatatgaa acaacctgta ctttctgttc tcttttctgg     8340

cagaaactgg ctctgaagac ttggagatac tgcctaatgg actggctttc attagctctg     8400

tgagtgtttt ctttcacttt tctgtgttct agaacgtttt ctaggactgg cagtttaagt     8460

ctttcactta ggctttctgt atacccatgc ccactttcaa ataaaatgaa cagtcatggt     8520

ttaaaagaca aattgtgtat gcatttacac ttgtgctata attatgatca tgcgtgttct     8580

atgcatattt gtgttcttcg gtctacattg aaccatatta cgttagcttc tattgcagca     8640

atttttttgt gagttcagtg tattcaagaa ttgttttcct ctcaattgtc tattccctaa     8700

gcacttaaaa ttgccatatt caaatatttg ctaaattaaa tatacattta atgtatacta     8760

cttcacaggt catttcaact ttcacatttt taaacaaatt tcagaataag ccctttaatt     8820

taaaattgtt gataggtccc aattcccaat tcccaagctt tgaagacaga atccaccata     8880

tttgctgaaa ctgtcctgca tatagatcgc tatggtagct gatatagtgc aaaacaaaag     8940

aagtccacca tctggcctag ggatcataac ataacagagt tgataggaaa cgacagacaa     9000

tcatccagcc atttaaaaac ctttgctacc ccttgtaatt tacttagtcc agttttctct     9060

tacaaagatg atagactagt catcctgcaa agcaatgtct tgcaaacttt cttgagcaac     9120

ataaggtgta tttcaagcaa aatcttatat gggaacacaa tatataaaac aacagcttta     9180

ttgttttgat tgaaggctaa gaaaggagta gttcctctgg cccaccaaaa ctctgtcttt     9240

gagatgcttc caaggaccta ccagggaaca gtttaaaagc cataagcaat attctctctg     9300

tattccttgc ttatatcatt gaagactatt attaattgcc tttttggtct gctcttccat     9360

ttttgatctt tctcatgggc tggaagctgt agtgtcgtgc acatatgact ttgctgcagg     9420

ggatgaaagg gtttgtgtgg ggtggcctag tggagcatgt ggcttccaga agacttctcc     9480

tggggaccca ttacagaagc taactaagag gcttcctatg tggccatctg gctagccctg     9540

tggtttggag cagtcaacat gaacccatgg gccatgcagc gcctctatta gcatttgaag     9600

tactggtatt gtgcttgatt tttctcctcc atggtttata agggattaaa gtatcctgga     9660

ataaagagct tcaaccccaa cagtcctgga aaaatacttc tgatggacct gaatgaagaa     9720

gatccaacag tgttggaatt ggggatcact ggaagtaaat ttgatgtatc ttcatttaac     9780

cctcatggga ttagcacatt cacagatgaa ggtaacaata tttactattt attaaaacca     9840

aaaccaaact taaaacaaaa acagaaaaac atgccaataa atgaattatt ttttctcatt     9900

caaacaaagc atagtcatga ataatgttct tactctgggt tttaaactta ccctctatgt     9960

taattgaact ttatagtaaa accacttaaa tacttgagaa tgctaaaata tttaagattt    10020

gtaaagcatc taattttgta aaatactaac attcacatta tccctataat taccataata    10080

ataatatcca gccctgatca ttatagcttt tccattttaa acgattttca agactcgggc    10140

atttacagga acagattttt ctaacccaag gcatctgtaa gctataggtc cagtgacaga    10200

aagtcaccat ggtcagcttt ctgccggtcc cattatcttc aatgcctcct gtccgctggt    10260

tcctctgttc tgtgttcaaa atgctcctct gcatgttggt ccctttcaac ataacttggt    10320

gtcatccttt atgtctttac tccctttctc cctttccatt tgctgtcact tccttgtctc    10380

tgtattaatt ttcagcccca gttgcacaat ggtagcacct gaagagttta aaaagactcg    10440

atgcccagcc cccagcttga cagattccaa ttccgttagt ctgagggagg cctggatcac    10500

agtagttgtt aaaagttttt cagttgataa aaatgtcagg ctagggttaa gaaccacgtt    10560

tatacccatt acctccattt catcatcaga cgatccctca ttcagttcct cttctggact    10620

ttccccactg tgggtggcta aaattgctac cttgagaatc atcagtgatg ttcctactaa    10680

caaatctcct ctcttccctt cctccctctc cttccttccc tcttcccttc cttccttcct    10740

tcacctcctt ttgttttttg ttttgttttg tttttgagat ggagtcttgc tctctcccag    10800

gctggagtgc agtggcgcaa tcttggctca ctgaaaactt cacctcccgg gttcaagcaa    10860

ttctcctgcc tcagcctcct gagtagcggg gaccacaggt gcatgccgcc atgcctggct    10920

gatttttcgt attttagtag agacgggggt ttcaccatgt tgcccaggct ggtctcgaac    10980

tcctgagctc aggcaatcct cccatctcgg cctcccaaag tgctgggatt acagttgtga    11040

gccaccgcgc ccagcctact tcacctgctt ttatgctgtt taccattttc tcattcacaa    11100

aacttgctct tccctgatac tgcagtgcac ctagctgttc cagttctcat cctactacag    11160

gttttctccc caattcattg ttttgtcact cattgctact tccctgagca ctaccccaga    11220

ggtttgatct tttacttcct ctatattttc tctattttag aactttcaaa ccagtgtcac    11280

actgcctgct ttctaggagg acatccccaa ataggggtat tattattctt cttcttttca    11340

ttagcccttc acttttaatg ccgcaggtgc ttactggaca cttctatttg gattcctttc    11400

ctatagacac tttaaactca aaatgttgaa agtgattttc catcctttta tctttccttc    11460

tcttccccat gtgagacaca cacacacaca cacacacaca cacacacaca cacatataca    11520

tatatatccc tttcaatgga ctttccactc atccacccat tcatcaccat tatgttttat    11580

tttaaaaata tttttaagta caaagaaata tagtgtttga tgtgtggata ctttttaaaa    11640

taaaaatgag gtaatattac acaacccctt ctataaattt cttctgcatt aaacactaca    11700

tcatggactc ctttatatat agcacatttg cagttgcttt gccaaggcag ttcgggattc    11760

agttgtgtgg gagcactgta atatagctca tctgctaaca aatatttagg ttgttcccac    11820

ctttatgctc attgcaaaca atgccaaaat aaactttctc gcacatgtat tttctgagac    11880

tatatcctta ggatacattt ctagaagtag aatccactgc acaaaatgtg aattcaggtt    11940

ttaatcctca cttgaatttg atttccaaca ccctccttcc tcagctgtat tcagggcctt    12000

tggattcttc ctgtcaaatg cctctcatga cctttcctgc cttttattgc cagtggcatc    12060

ctcttggtcc agtcctttct ctccacattg ctggattact gctgtagcct cagctcatgt    12120

tactccttgg ttcaaatacc ccagtgagca aagcttggat cttcatctta agccctaaca    12180

agactgattc tggctccctg tggtttcagc cctctcactc tcccactctc tcttgccttc    12240

actctgctcc cagcacaacc tcacaattaa gtgaatatgt ccaggaagtt ctgccccggg    12300

gcctttgcac actcccagca caacctcact attaagtgaa tatgtcccgg aagttctgcc    12360

ccggggcctt tgcacactcc cagcacaacc tcactattaa gtgaatatgt ccaggaagtt    12420

ctgccccagg gcctttgcac actttctccc ctcaacctgg aatgctcttt ccctagatat    12480

ccacattatt cgttctctta tttcacttag gtttttgctc taacatcccc tcatcagaga    12540

gaacatgcct gactcccatg aagataatac ttcgttactc tctattcttt tatcctgttg    12600

tatttttcct ttgtagcatt taacgccaac taaaataaat taaacacttg tttgctgaat    12660

ggggtaatga aaatcatttt agcagctttc tctgttcaaa tcttctcaat tcaacctgcc    12720

aaattttgca tcttaacatg gtgaaacccc atctctacta aaaacacaaa aattagccag    12780

gcatggtggt gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatcgctt    12840

gaacctggga ggcggaggtt gcagtgagcc gagatggcgc cattgcactc cagcctgggc    12900

aacaggagtg aaactccgtc tcaaaaacaa aacaaaacaa aacaaaaacg ccaatttgat    12960

catgtcagag gtttcaaaag acctactctt tcttaaggca aagaccataa tctaactttt    13020

acttgccagc tctgatcaca cattcttgac cgcttagact ggtcaccttt gtgttcttaa    13080

agtcccactt atccaaggaa gctgcttctg tttgtttgct actatttctc agatgttctt    13140

ctatggaatg tatcatctca cactgtgtaa attacacctg atcacacctt ctcatattgg    13200

gagttcccat ggtttttatc cctttcatcg caactgtgca tttcgtggag accatttgaa    13260

ctggaaaact taaaggattc tttggagttt tagtgtcagt gatactcatt cttgagaatt    13320

tttttttctc ctgtggagtt ttgagttttc agagactgtc actggttctt ccttgagcca    13380

cttttgtttg gaacaggagc aatcaccaat gcttctctct acaaagagat gaaaatattc    13440

catctgcctg acatcctaac tactagctgg aggtgggttg aaattggttt ttggagagag    13500

ggctgacagt gagagcttag ttaatgtttc atttttgttt ttaatctcct ctcagataat    13560

gccatgtacc tcctggtggt gaaccatcca gatgccaagt ccacagtgga gttgtttaaa    13620

tttcaagaag aagaaaaatc gcttttgcat ctaaaaacca tcagacataa acttctgcct    13680

aagtactgag atatatcaca tttctatttt cctttagctg tagcggatag ttaatccact    13740

tttagttttt ccttttggcc agagtaggta tggctgttca actctcattt ctaatgatca    13800

caaactcctc cacatgctct tctgaagaac cttctgagga ctcaagcccc tcagagacgg    13860

cccattcttt tcctctcttg tttctcgagc tgattggatg ctggctcctg gcctcaggat    13920

ctccattcaa gttattacca ggaaaaaaat cctcttcttc agaaccagac ttagtatttc    13980

aaacccaaac cggcttcata gataaatttg acatcatgag cttatttatt tatattaaaa    14040

agtagactct tagatgtttc catgaattag aaacacagac ccaagaggag accctgaatc    14100

aagtgcatct aagacctcct tatactgcct ccgctgctgt ttgattgcac aaaatttatg    14160

caatagcaga tctgtggtaa cactcaattc cccctaggca ccttgttcat gtaacatatg    14220

gtgaaataaa acactcaaga atctccaatc tcagtcaact tcctcacatg ccctgtgaag    14280

atttggcttg taaggccagt gatggattta ggagaacaat ccgactctat cttctgaaac    14340

atttacctcc aactgattac gattttctag aatcccaacc tatttttata taatttatgt    14400

acagcatttg actacctcca tatctgtaaa tctagatttg tactctttgc aggtacctag    14460

ctaagggcct ggtatgtagt gtgcactctg tgttaccagg accccttcct cttctttctt    14520

atctggtggt ttgaggatga ggaaaatgag attggagaga aattgagtta ctggatgaag    14580

gccaatcaac tcactagtgg ccaagtagga accccagctc aggtcatctt ctgccccatc    14640

aagatgaata aaagttcaga gaacagcttt tggtggaaga gtttattcgt gcatttattt    14700

aacaaatata ttttggagag agaataaggt cactgagtgg agaatgtgag gaacaccaag    14760

atttaaagta gagaacagta tgtagaatgg agaagctggg caaatgataa cactaataaa    14820

tgagctttct ctgtaagtca ggtgctacac taactaattc aaacagatta ttttattgat    14880

gttttacaaa taccttctga attaggtgtt attattatat ccattttgga tttttaaaaa    14940

gttgaggcct ggactaattg ttaagtttcc ccagatgaca tcatcagtaa atggtgcagc    15000

tgtgattcta atcctggtaa catgagttca gagctggtgc tttaaacctc tacaaaatag    15060

tgaaaaaaat tatgtgtttt aacatttaat cttggaaatc tcagattggt ctacgttacc    15120

ggattggagt atttttttct tgagccagtt gcaaaaatat tggtcttagg cagcattgga    15180

gactgaaaat aaccacggtg ccgtaattaa ctagagttct gctctctcaa tccaaggatt    15240

agctgtgtgt attttcttct ttgtatttta tggtttttta taacattaat attccaataa    15300

ctaaatctat tataatttaa acttgttatt attcatatat cacaactgtt attattggtc    15360

atttactgta tgccaggcat ggtgtgaagg cctttgcatt cattatttca ttgtattctt    15420

actctagcct ttcaaggtat acagagaaaa cagaggttca gaatagtggc tcaaaattta    15480

gtgacaatgc tgtggcccca cattataagg atagcaagca gtgtcaggat gcaaatgaag    15540

tccatcagat ttcaaagcta ttactctatt accctttaaa aatttgttat ttatttactt    15600

attttactac acctgggggt agtaaatttt cagcaataaa aagctattgc tctaaaccat    15660

tccactctgc ccctttctgt gaaaaacaga caaatgatag tccagcatac taatttaaga    15720

aatttacttt taaaaaagag agagtaaaat cagattgtag atttatgtct ggagcccatc    15780

cagactaatc ctaaattccg agaccttttt ttttttttca tgttgtaata gtggctagca    15840

ttgattgagg gtttattgaa tgtcatgctc cctgcaaagc acacaacagg cattgtctca    15900

ttgtaattcc cactgcaact ccacaaatta agatcctgac ccttagtttt ctactaatga    15960

gctgtatgat tttgagaata tcatttaacc tctctttaca gatgagaaaa ctgaggctct    16020

gcatgcctgt ctaacttgcc tgagagctca gagctgcgtc agagctgatg cgctggccat    16080

gacgcctctg caatagagca gagataattt tctcccagat catgccctgg ggaacttcca    16140

tcacctcaat cagcaaagaa tgactcactt atgtgttccc tattgtatcc attaaagcag    16200

aaaaatagac tcatatatct tacattttca gtaacagaga atcctaatca gaaaggaaaa    16260

aaaaaaagcc atagcattct atttctgagc attcttgttc atggacattt cattcagttt    16320

agaatcacga aatcttaagg ctggaagatc aaccagtcta tcatcctgct ttcacagata    16380

agaaaactga ggtcctgaca tgtgaaaaga ttgatttttc ttagatcaca cagctaatag    16440

tagcagagct taaactaaaa tgcaagtatc caggctgctg gttcagcatt ttttcaattt    16500

cttatgggag ttagttctat gtgagcccag atatgtgagc acatttttgc cctgacaatg    16560

atttctggct taatttaatt tctactgaat ttagtgtatt tacacacaga cacacacaga    16620

tacacacaca cacacacaca cacacacaca cacacacgac gtaacactat tttaagatac    16680

atataatagg atttttatgt tacagtgcta taatcacctc ctcagatttc ttagaccaat    16740

gattgtctaa ggattgtatc ggcaggacta atttcatatt aattgtgttc cattatagct    16800

agcacgaagg ctccatccca catcttgatt ttaggaatag acagtgagga atgccagtta    16860

ataatcctgt aatgttcaat accttcacct tatatattat gtgtgtatgt tttaattgca    16920

gtttgaatga tattgttgct gtgggacctg agcactttta tggcacaaat gatcactatt    16980

ttcttgaccc ctacttacaa tcctgggaga tgtatttggg tttagcgtgg tcgtatgttg    17040

tctactatag tccaagtgaa gttcgagtgg tggcagaagg atttgatttt gctaatggaa    17100

tcaacatttc acccgatggc aagtatgtga actctctgaa atgtagtgga tttactcaga    17160

ttctcaggag atatcttgga atatattctt tttttaagta atatgataca ttttaacatg    17220

ttaccctagt gagataaaat taggaaaaat gtaaaatgtc ttaatttttc agggggtgaa    17280

atttatcaaa tcaaaaattt cattgtgaag gcatactggt tttatttcct ttttggaaag    17340

aaagtacatt ttaagagggg gaactgtgat gaagatttga tatgtctgaa tagctttgtt    17400

ttgagtaaag atgtgagtgt ataatgagtt gaatagtatg caggtataga tacgtcagta    17460

gtgcaggttt atgacaagat gaggaatttg taccaaaatg taaatcaagg caatacttcc    17520

ttcatcaaga aagtattact gtgaaaaaca agtcagttta actaagcagt gtgcttagtg    17580

atgtatttga tttataatgt tatctcatgg tgagctataa caaacaattt gcaaaccaac    17640

attggtctgg agactgcatt ttgggtagca ttggtatata catgaaatat ctatatccat    17700

ccacatatat gccctttctc atcttgtgtc atcatcaagg attttagagt ccgtaacata    17760

tgcttagaga aagcaacagg ggccaggtgt ggtggttcat gcctgtaatc ctagcacttc    17820

gggaggccaa ggtgggtgga tcacctgagg tcatagacca gcctggccat catggcgaaa    17880

ccccatctct actaaaaata caaaaattag ccaggcgtgg tggcgcactc ctgtaatccc    17940

agctaccagg gaggccaggc aggagaattg cttgaacctg ggaggtggag gttgcagtga    18000

gctgagattg caccactgca ctccagcgtg ggtgacagag caagactctg ttttttttta    18060

aaaaaaaaaa aaagaaagaa agaaagaaaa gaaaaagcaa gcaagcaagc aagtgagagc    18120

aacagggaca gggacagctt ttaattattc atatcataga ccagttttca aaaaatagaa    18180

gataattgag cagtaatttc ttttttttgt tggggggatg cacagtgctt agactaaccc    18240

cagatctttg tggggtatga ctaaagccac agggtcagga ccacactcag ggcagaagag    18300

gaggaagact tctcttgatc caagccaagc agcttttctt ctctcatatt ttctctggat    18360

taaaacaagg ggctgttgtc caagggcttt cctgcaactt tcccgagaga gaactcacta    18420

gcccctgaaa tgcagaacct gggccttgac actaaattgt caaaccaaaa gagaaacgct    18480

gtaatgcatt ttactcccag atactaaaag ttagtgttag ggctaagttc ctcccatact    18540

gataaggaca actatgtccc ctccttcaga aacaactttt cagagattaa acccctctgt    18600

cactgtaaac tcactgagtt ctttcagaat ttggtgtgtt tgaggtgggt tccattttcc    18660

attccttaag caaagttctt ccctatgaat aggtattaca acttcatctt aatctctcaa    18720

gttgtgttac ttctagtact ttgatgtagc tctttcttct ttgaaggtat gtctatatag    18780

ctgagttgct ggctcataag attcatgtgt atgaaaagca tgctaattgg actttaactc    18840

cattgaaggt aagacgtatt aacactgtaa gtctgcagag tgataattag attctaattg    18900

atttgtgaaa ttaaatgtga agaaaaaagg actgcttaat tggggtgggt gagaaccaat    18960

ttttcactcc tttattaaga gtcattagct tggttatgtg tttgttgttc atttttactc    19020

aactgcagag tggcaaacag caaaccccac ctcttacccg tgaaccttgc attctttctg    19080

ctctagcaaa ttttaagctt ggcattgtgt tcccagatcc tccttccatc cctcccttcc    19140

tgcctttctt ctgatctccc tctcctccac cttccttccc tctcctccct tttctttctc    19200

ttttttcctc tatgttgatg gaacagccaa gaaatagcct caaattgtac tttatgcagg    19260

gctgctctcc acaatgttta tgaagtccac gtgctcacga tggctgctag gtgacctggc    19320

tgcccctcac ctctctgcct ttacctccaa ccattgtgtc cctgccccac gtctcctgcc    19380

actgtctcag aacggggcac cattccctct gctaggagga gaaaccttcc tccagatctc    19440

catgaccccc tccttcatct cctttcattt ttactaaaac gtcacctcga tcttcaaaac    19500

ctggaactgc tccctcccgc tacgtatttt ccctcgcctt tcctgcttta tttttccatt    19560

cagcacgtat tgctaacata ctatatattt tattcatacc ctttattacc tgattcccca    19620

actagggtgt aagctccaca aggacaggct gtttttctat ttgcttctgg tacaattcac    19680

attgactagt tggcacttaa caaatacttg ttaaattact gcggtggggc tgggcatgct    19740

tcagggattc acctgctgcc cccaccaatt ctggtcatct gaaggttgga gtcaaaatgg    19800

gtgaaaacac aaaggagagg aaaaagagac caagagcaaa ctagagccct aagaaagcag    19860

ccctctacct ccgaaaaaca gcaagacgtt gctttcctgc cataaacgcc cactgcagga    19920

agcactgtca gcgccaattg tatgactgtt cctgtcagca catctgagag actgtcatga    19980

ggggcctcac tcagagaaaa ttaccttaaa gcaacatcaa atgtaacatc gtgtttgaca    20040

ttaaaaatca ctggcagggc tagtttggta ttagctcaag taaaatggaa tttcacacgc    20100

tcatactggc taagggaata aaaaacaagc tgcggtttta acaacaggta tttctgtaaa    20160

acaaaagtta aagaatttta tgagaataga acccaatgta acagacattc accacagaat    20220

gtcaaggctc tgctctcacc agggtgagac tgagggcaag gccagtttca gcaacagacc    20280

aggcctgtct cccatcatga aaaccccaaa aaggttctcc atcaattgtc acattattct    20340

ttcttttgaa agaccgtatt aattaatatc agttaattaa tgcccgagag tgccaagtaa    20400

tttgataaac tagctgaggc tattcttaaa tttgtgatga ggtgtggatg ggtttatgtc    20460

caattggata ttgttcagcc ttaaaaagga atgaagttct tggccgggtg cggtggctca    20520

cacctgtaat cccagcactg tgggaggctg aggtgggtgg atcacgaggt caagagttca    20580

agaccagcct ggccaatatg gtgaaacccc gtctctacta aaggtacaaa aaattagcca    20640

gacatggtgg cacatgccta taatcccagc tacctgggag actgaggcag gagaatcact    20700

tgaacctggg aggcggaggt tgcagtgagc tgagatcaca ccattgtact ccagtctggg    20760

caacaagagc aaaacgccat ctaaaaaaaa aaaaaaaaaa aaaaaggaat gaagttctga    20820

tacctgctac aacatggata agccttgaaa aacatgatgc taaatgacat aagccagcaa    20880

caaaaggata aatattgtac gatttactaa taggaagtac ctagaacagg caaattcatg    20940

gagacagaaa atagaataga atggtgattg ctaggaactt gggggagaga agaataggga    21000

gctattgttt aatgggtaca ggatttctat ttggggctga ttaaaagttc tggagaggga    21060

tggtgatgat ggttgcacaa cattgtgaat atacttaatg ccactgagtt ttacacttaa    21120

aaatggttaa aatgtcaaat ttttatatat tttaccacga tagaaataat tctctcctct    21180

ctccaaaaaa agattccagg acttagtcaa tgaattagtc acacttcaat gaacctcaat    21240

gcgcaaaaac ctggaatatt tgttaacaga gaatactctg tttttcccaa agagaataat    21300

ttattatgtt ttcttgacca aggaatgcga atttttcgag ttgcctttgt gggagtgtga    21360

gatgtgatac gcaggggtct tgcatgagtt agcatggaga ggaattattt atttgcaagg    21420

caaagagttc attgctggac tcagaacagg ctccctgcta gactgtcagc acttccatgg    21480

catgagctgt gtctgctggg tacctggtgc tctccaggtg ttgcgttcct tgcagagctc    21540

atgtaggagc tcagtaattg tgtcttgaat gaatgggacc ccaggtttct gtgtccttct    21600

cccactccca ctctcatctc aggtttcatc tgccgtggaa ttcaccaatt ggctgtactg    21660

cttccaaaga taagagcaaa gccctgaaac aaacattttc ctcattcaaa gacattatgg    21720

tatcagagtg gtgtgctgac actgggatgg acaggggttt agggatggag aaagcaagca    21780

tggagccgcc tgtcttgcct gtctctgggg taagaaagac tgatggctct gcatggtggc    21840

gagactgagg ctctgccatg atgcttgagc cctctaatcc ctccttgggc atgtgaggaa    21900

cagctctcat tttgagtagg aggcacaggg aaacgttggt tttctgcagc tgtctgctta    21960

tgccctggct ttttcaatga gtcatgacca gttatttaca ggttctctgg gcactgaggt    22020

atgctggcct ctgaggtaca tggtagatat tatttctcca actgagaatt agaggtaaac    22080

aaatagatgg gatttctccc cagtagaagg cagccaagat gatgaatggt ggaattaaga    22140

atcattggta ttatttatga tccttgtaca aagcctcgac agcaatctgt gcagtcatca    22200

aatgcttgca acttatattt agagaataaa cagcagaaga acggggagtt gaacaacatc    22260

aggaaactaa agaacaaact tttcctcaac tacaaggcaa aaatgagacc ctgggtgatc    22320

atttcttctc tggctgcaca gcctatgatt agccattaaa gagtccacat ttcattgata    22380

ttcttctgag aaagaatcta catttcctgg ttgttttctg aatgcttata aaaatatcat    22440

taccacatgc cattttagaa ggagatgttt tatgatgcac cgaaaacttc tttttttttt    22500

cagttttagg ttcatgcaca gatgttggta caaatgattt tgtctaactt ttaacagtct    22560

ttcttggctt tctgtatctt caccctaccc aattctgccc tggaaactga caaaatacta    22620

gcatagatga aaggtcagag aaattttgtg agtcttattg aaatggggca gaattgtatc    22680

cttggaagca gcagcgtggt gaccaaggac aagaggcaac ttttctctga tatattttgc    22740

tccatcacaa ttgtgtttta ctttatgtct tgttcttttc ttgtttttaa tcttttaagt    22800

cccttgactt taataccctc gtggataaca tatctgtgga tcctgagaca ggagaccttt    22860

gggttggatg ccatcccaat ggcatgaaaa tcttcttcta tgactcagag aatcctcctg    22920

catcagaggt aagttttaaa aatgaaccag ataagtgact ttattcccag ctactgtttt    22980

ttcagttgac aacataattc tcaattcttg gttttttttt tttttttttt ttttttgtga    23040

cagagtatcg ctctgtcgcc caggctggag tgcagtggcg caatcttggc tcactgcaag    23100

ctccgcctcc cgggttcaca ccattctcct gcctcagcct cccaagtagt tgggaccaca    23160

ggcgcatgcc accatgcctg gctaattttt tgtatttttt ttttttttta gtagagacag    23220

ggtttcatcc tgttggccag gatggtcttg atctgctgac cttgtgatcc acccgcctcg    23280

gcctcccaaa gtgccgggat tacaggcgtg agccaccgtg cccggccaat tctcaattct    23340

atgtgcaaat aaaagggggg acatggatag atgatccaaa tgatcagaaa tgaaggcttt    23400

tggaggtgct ttagtcagag tctaggcaag aaacacatgg cacacttaaa ttggataatt    23460

tgaggggagt ttaatcaacg gactatacac aaaatgtgtg gacacagtgt agggtaatca    23520

acagagttat aatgcagtac cccagggcta gcaagggagg gaggaaatga ataccagaag    23580

ccagaacagg tagacggtgg tgggtggaga gggttgcctg acaggaactt ggcctctggt    23640

taagggatcc tcaaagaaca taatgatgcc atactgctat ggtttaatca ttcattacct    23700

gccttcctat tcaactcccc cttcctgtgt ggcggtatac gcacaggtcc atgcaatgga    23760

ccagtcctgg agcacactgg ccagcctctc tagatcttcc tgcaggtggc aagataaata    23820

gctggaatta ttctggctta gaagatctca tcttccacct tagttacagt actcaaaggt    23880

cccatttttt gtccacggtc tttattcagt gaactatttt gggtacaagt aagaatttgc    23940

aacctacttc aatataggta tttgcacatt tactgagttt tcagtatcta ctaaggatac    24000

ttattactta catcatatat atgatatcat cttgacatat ttgtctactg ctgtgtattg    24060

ttaaagctca gttttaagag tccatttcac ctgcccaaca ggaaaaaaaa aagtgttaaa    24120

gcccgtatct cttgggttaa aaaaaaaaga aacaaatgtg tatttccatt tacattatgg    24180

ctctcttacc ttttatctct aggtttgcag gacaattgtg atcatgttta atggcaaccc    24240

tttgtgcctt ttgctagttt ttagctatta gggttgctga atggtatgtt taatagaatt    24300

gaagaaatgt atgctgtgga gtgttcagtg ctcagaactg agcagaatgt tagattctaa    24360

tttgttcttg cttgttagct catttagtaa ccttgggtca tttgctatag catggacttg    24420

gtttgttgtt ctggagaaaa tacttcattt ctaatgattg atctgcaaag gagtagcaaa    24480

aagtagtaac aattccttat ccaatgcact gcccctagat gagtgattta gttttattaa    24540

caagaagctt agctaagcca aggtgtacca tcaactattt ccctgtaact actacatgtt    24600

aatgctatgg caacttccta agacatctgt ctttggtgcc agctgttttt aagaggtcat    24660

tttgaacgtt cccacagacc cttttatatc cacgcagtgg ccttcaccgt ctgccacatt    24720

tgtgatgtag atatcctttc ttcaagtcat tatatattat cataaaggct taataataga    24780

aagctagagc tgaaggggaa tttagagata atctagtccc acccatttca ttctacagat    24840

gagaaacaaa tgtgagtgga agatccaaga catgacccag gtctcccacc tcagtgtagt    24900

gcttttcata ctaagttgaa tcacacgcta ttgctatttt ttacagtcag aatgatcaga    24960

tattggctat ttcatatggt tggcttaaca tgatactaca ctgttattat tgatacaatc    25020

acatttctcc tcaattaagt gaaggaaact gaacttacaa aatcttatac atttagagac    25080

aggaggttaa gttcagaaca catgagtatg gtacacagat atggtttttt gagggccaca    25140

ttttttttct tgtctgcatt ttaaaaacca ggaattaagt gtaaacatcc agttagttcc    25200

ctggcttacc tgaaaataca tgaaaacgga ccttaattac tgcatggcaa cagtttggct    25260

attgctgagt gtattagtca aggttcccta gagggacaga actaatagga tatatatata    25320

tgtaaagggg gtttattaag tattaactta cctgatcaca agatcccaca gtaggcggtc    25380

tgcaagcctg aggagcaagg agagccagtc tgagtctcaa aactgaagaa tttggagtct    25440

gatgtttgag ggcaggaagc atcagcatgg gagaaagatg taggctggga gggtaggcca    25500

gtctctcctc ttcatgtttt tctgcctgct ttatattcgc tggcagctga ttagattgtg    25560

cccacccaga ttaagggtgg gtctgccttt tgcagcccac tgactcaaat gttaatctcc    25620

tttggcaaca cgctcacaga cacccaggat caatactttg catccttcaa tccaatcaag    25680

ttgactctca gtattaacta tcatactgag taacagcttc ctccctccac atttactgaa    25740

atccccactg ctccctaatg tcccacatcc aggatgcgct gctcatttgc atttcctgcc    25800

tcatccctgt aggtctagat actctccacc tctgctaaag atcacttgag atcagtaccc    25860

acctgttccc aaatgaagaa acaggtgtgt taagtgtaat tttggaacaa aataggattt    25920

atctcattgt ataagattat atggcttctt atggaggatg accctattat gcataaggtt    25980

gttttaagtg acttaacaaa aatattaacc caatgttatt tcttccacag gtgcttcgaa    26040

tccagaacat tctaacagaa gaacctaaag tgacacaggt ttatgcagaa aatggcacag    26100

tgttgcaagg cagtacagtt gcctctgtgt acaaagggaa actgctgatt ggcacagtgt    26160

ttcacaaagc tctttactgt gagctctaac agaccgattt gcacccatgc catagaaact    26220

gaggccatta tttcaaccgc ttgccatatt ccgaggaccc agtgttctta gctgaacaat    26280

gaatgctgac cctaaatgtg gacatcatga agcatcaaag cactgtttaa ctgggagtga    26340

tatgatgtgt agggcttttt tttgagaata cactatcaaa tcagtcttgg aatacttgaa    26400

aacctcattt accataaaaa tccttctcac taaaatggat aaatcagtta tgtcaattgt    26460

cagatattaa ataacagtgt gtgaccccaa aagtacttac cctaaaacat gtgttgcctg    26520

gaagcacatg tgtgtatcgc tgccttgcca tgtcttgttc agaagacaca ggggagcagg    26580

gttagctcac gtgtctttag aactccagta ctcacccagg gactccagtt cacaggccag    26640

aaaacatatg cattatgaag ttcccctcta ctccatgcac atagtaagtc tgactatggc    26700

agtcagactt acttactccc attttccctt cgatatatga ctttttctca gtaaatatta    26760

acctgaatta ttccaactcc ccttgtactc ttgctttttc aattctcctg ttgcaatgac    26820

acataggaaa atcttaaaat tcttgggagt gttgtcacac ctgaaaatta tgagtctcta    26880

tgatcttggc acaaattgta catttgagtg tctttgactt ggttaaagga agtttgttca    26940

cttcgatgac tggatacaga atgaatccca taattgacat gggcgaagct aaaagtgtcc    27000

ccaaagacta cactgttgtt gaggtggtgg tagtgctggt gggtttttgt ttaatattta    27060

aacttcttgt tgtggaggct gaaaagaaaa aaaataatag aaaggtaaac aaacaaataa    27120

atagaaaaga tcaacaaccc ctttggctat ctactgagac atgactagga agaaaacatg    27180

actttatcat tttgttatag aaactgatat ataaaggtta cacattttca tttatttgtt    27240

tttctgattt gaaggtataa ccttcatgat gaattacttc ttcagggtgt taaggcagtg    27300

actttagaaa caaatttttt tcttgttttt gttttgtttt tgagaccgaa tctcactctg    27360

ttgcccaggc tggagtgcag tggtgcgatc ttggctcact gcaacttcta cctccgaggt    27420

tcaagagatt cttgtgcctc agcctcccgg atagctggga ctacaggcac acaccaccat    27480

gcccggctaa tttttgtatt tttagtagag acggggtttc accatgttgg ccagcctggt    27540

ctcgaacacc tgacctcagg tgatccaccc gccttggcct tccaaagtgc tgggattaca    27600

ggtgcgagcc accacaccca gccagaaacg aagtttttct aaggcacttg ttatgatgat    27660

agtctggcat ttccgggaaa atgttttgcc aataaattga gaaccaccaa cagttgttta    27720

agaatcactg acttgaagta ataaacagga acattttgtt tgggtcaaaa aaccacttta    27780

ttcacagcaa gattggagtt actcatgatt ccagtgacat aatatcccgt gccctacatg    27840

ggctcaattt ttctgagatg ctgctcacag cccaggatgc tgggttctct gaaagactgt    27900

cttgaaatta tcaatgagtg tgatgcttag ggaacacccc caacatattt cattatttag    27960

aaagaaagaa tttcctgagt agttaggctc cctaacatct tcaataaaat gaccacattc    28020

tgttctttct tgttcttgat gatagataag caaattc                             28057


<210>  6
<211>  355
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated PON1 protein (amino acid change L55->M)

<400>  6

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Met Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  7
<211>  19489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated prg4 sequence; mutated base: chr1:186304862 (C->T); 
       mutated codon: Cgg->Tgg

<400>  7
taaaggaagg atctaaggaa aatatcaata cattttttaa gcagattttt aaaataataa       60

aggaagctag aaaatccagt gtcaataatc tacctgtagg taactgagag catgttttct      120

gtgctcagag aaaatgaaac tactcaagaa atgtatattt gatataatgg tataagtata      180

taaaatgtat gccacaagct aacactaggt aaatttcaaa gctacctttg ctagatttaa      240

ctggaaagca gaagaaataa atgataccag tatgtgaata ttttaaagtt gctgcttcaa      300

tatactagtc aaagtctgcc agagctattt accatctcag gacaatttgt tcacttcact      360

tagaaattag aaatgtgctc tggccaatac atctaaattt attttgtggt agtcattttg      420

cttaatggaa gtgttttcca gatgttgcct aagtctagtc gtctgggccc ttttccaata      480

aatgaggaaa gtttgatttc ataggttgtc actgttgatt ttgtctaacc tttggactaa      540

ttggttcatc ccactgtatt tgcactgata tataagactc ccaggacgtg ggataaactc      600

atctatcctt tacgggtaag tgtcaaagtt aacttgcttc atagaattaa atgtgttttc      660

attagaggtg tttgaaaaaa aatgtgtaaa gatagtagtt ggaaattttt gaaaaggatt      720

atgtttatgc aatacacctg ttggaagcct ttgaatttat attgagaatt aagaaaaagt      780

tggaacagta actccatgat gcttattaaa ttacatttct gtgacacagg ttattatttt      840

ccttaagata aaattttaac cttgcactgt taagtacatg ccatactttg gctagagttt      900

taagataagt ctattctata ttggagattt cttaagaatt aaaactgtca ataacgtggc      960

tgagggtgac ttgatttgtt ctgcataaga ttaagtctaa tggccaaata ttttctataa     1020

aattaaagct gatttaaagt cttgtttcaa gaatgggatg gttttattat tgttacattt     1080

ttaaagttac tgaaatgtgt ataatgcaag cctaagttag tggtgagatg aaagagctgt     1140

tttctgatac ttttatttta ttttcagcaa gggtacctac ggtacctgaa aacaacgatg     1200

gcatggaaaa cacttcccat ttacctgttg ttgctgctgt ctgttttcgt gattcagcaa     1260

gtttcatctc aaggtagctt aaccatcgaa catactttta tttaacaact attgctaatc     1320

attcagtctt gatttttata acaacggaaa tatatttcta aaaatttata tttgcttgag     1380

tttaatatac tgtacaacct taaaataata tataacatgt agcctgtttg taagtgcttt     1440

ggaattctca tctttttctc cttttgagag ttttgagctt gtataaagaa taattttggt     1500

acttgttatt tctatggttc tctcgaaagt ttaaaaagtg cagacagttc atcataaaat     1560

tatgctggag ctatatagta tcataaaaat aactaaaaaa gaacaatatt tagataacat     1620

gtaatttttg cctatatgtt gaacaatttg ttttttaaaa tcaaataaat tattgataaa     1680

taacttattt tggcatcatt tagacataga taccatatta taataaacta tagtgtttca     1740

aatggcattt tattagtctt gaaaatgttc tctttttctt acaagaacta tttatccagg     1800

tatggacata tacagatgtg actgtcattt tgtgttataa cattaaactt ttcacagttc     1860

tcccaaaaca ggtcctggat gaatagttct tgttactcat ttttagagac tgttaaagta     1920

cattcagtga aatcacatta gtaaaagatg ctagcatgcc atctaggggg attaatagta     1980

acaatgccaa gctttggatt tttcttttct tttcttttcc ttttgttccc ctttgataag     2040

caaaatctga gagaataaaa atcaagattc atgacagtta tgatgaaatt atgtttctaa     2100

agtaaacatt tccagtaaaa tacgagattc ttatgaaacc tgaacatgag tggtaactgt     2160

ctgcataggc ataagttgca gaattgttta gataagaaaa gacaggaaaa cacatgaaag     2220

caaatgtgaa tattcaataa gaatgatgac tactccagta tctccagacc cttcggcttt     2280

ctcgtaacac tatgacaagg ttcacaacac tgggggcact ttctaaactg ccttttcctc     2340

tgtgatacaa ttggttgttc actaaaacag tgttactttc attttaattg tgattaaata     2400

aatcaaatta aaattaatgg ggctgggtgt ggtggctcac acctgtaatc ccagcattct     2460

gggaggccta gggagacaga tcacctgagg tctggagttc aagagcagcc tgggcaacat     2520

ggcaaaatct tgtctctata caaaatacaa aaaaattagc caggtgtggt agtgtgtgcc     2580

tgtaatccca gctattcgga ggctgaggca agaggatatc ttgaatccag gaggtggagg     2640

ttgcattaag ctgagcttgc atcatggcac tccagcctgg gcaacagagt gagactctgt     2700

ctcaaaaata aataaataaa taaataaaat taatggttac aattaatagc aataaaagta     2760

ggacagacac ctaatctatg aaagtaagct tttcctgtaa ggatgatttc ctcttttttt     2820

tttttctttt gagacagggt cttgctttgt ctcccagtct ggagtgcagt ggcacaatct     2880

tggctcactg caacctccac ctacggggtt caagcgattc tcctgtctca gcctcccgag     2940

tagctgggat tacaggcccc tgccaccatg cccggttaat ttttgtattt ttagtaaaga     3000

caggttttca ccatgttggc caggctggtc tcacctgacc tcaggtgatc cgcccgcctc     3060

agcctcccaa agtgctggaa ttacagatga tttcttattt cagaaatctg ccaactataa     3120

aagagcaatc tcttgatact gtcttgtctg cttctcttgc tttctcaacc tcttctcatt     3180

ctcttttttc tttatatata atatatgtat ttatatacat acactatata tacatttttg     3240

tatgcattat gcactcatgt acgcaaaaag ttctgaaagt tgtcctacaa tttactgttt     3300

tatttgcata ttcagacttt ggcattcctg gactctattc ttttaagatt tgttttcagt     3360

gtgtttcaac attcctttgt ggatttagga cagtacacct gccaatttct attccaggga     3420

tggattccat tgtcacattt ctgcagtcat ttctcaggga gggttttaag gtggtgtttt     3480

ccaaatgact tttaaaaaat atttgagaat gagtatgctt ttgttattgt ttgcttattt     3540

gttgcctgga aaacctctgt tcatgacctt tatagttatg cccagttatt ttaagggttc     3600

tcacttcagc agtggttgta agcatctgcc tcccctgaca ttttaaaaat ccagttatcc     3660

ccaccaatta aggaagaaaa agctcagtaa agtttatgct ggtgcaacca gcgtgcttta     3720

aacttatcct caggaatggg aggcaaagcg acaggtggaa acatctcagg cttaaaataa     3780

gatatatcag agttcaaatt ctggatggat tgtttactta aggtgaccat aaaatgtatt     3840

atctaaatta ggacaattat aagggtaaaa gagttcacta caaataattg ggaggtatta     3900

attaacctat gatgccaata tactggaact attaactagt cgtgtgataa tgagcaagtt     3960

gtcaaaattt ctgtgtttca gctttcttag ctctaaaaaa gggctactaa atcctggaaa     4020

cattttcata agcattagtg ataatgtatg actcagcacc tggcatagag aagctcaata     4080

aatggcaact gctaatcatc aaaaccacag atcggtagta gctgtagctg ccacctcttc     4140

cttaggagta tcaccctctt taggcaaagc cattactttg cctggttttc aaaaatgtgt     4200

ttatcatctc agtctagtga agaataaagt gacataattg agatcaccta agacatcagc     4260

caaatatcag ctgggcctat tgctgacatc attccaacac cttctcgatc aataaaattc     4320

tctctcacca agtggctttg tccccctcgt tagattgctc cctttctata aagtggtttg     4380

gccatattta cgccagtatt gtataatttt agatttatca agctgtgcag ggagatgtgg     4440

ggaagggtat tctagagatg ccacctgcaa ctgtgattat aactgtcaac actacatgga     4500

gtgctgccct gatttcaaga gagtctgcac tgcgggtaag tcctgagagc gggtgtctcc     4560

tctgtcaagc aacactgcga gtctgtgagt ccccccttgc accctcgtgc agtgctgtga     4620

gactgagcct ccccttgcac ccacttgcag tgctgttttc ccactgtatc acttcctttg     4680

cttaagtgac tttccttcac ttgcataaat gttgcagcgc attgtaccta aggatggtgt     4740

caaagcttgt gattattggg gagggtaagg ggagcctgga agtctgtcac ttgcacaagg     4800

ttattgtcta gttccaagta aatgtcttat tttaaataga gaagatactg tgagtcagga     4860

gtcattaagt aaatagtaag gagtaattat ttacaatcag agatgtcctc gactagtaat     4920

gaggactttc aatagtttca tcaaaagaat acatgagcat ggaataatct tgtctaccat     4980

tggactttct gatgttaaca cgtttgtaaa ttacctggaa aagacacttt aaagataaag     5040

tgctagtgtt taatgatgaa tttcagttaa aatctgaagg tctgaatttt aaattatgag     5100

tggtgtttca cttgaatata ttttgggcca ttttattatt aacacagaaa catttcctat     5160

tcaatttaag aaaattgtaa ttaaagttat ttgaaaggtg tatttgcttt agaatttgaa     5220

tgtgaagttg aggaatatat tgtgcaattt atgtattgga taggtaatta tttcaaataa     5280

gccttggtaa gtccctgtta actctaacaa aggcttttta aattttcatt ttttaaatga     5340

gtagtcctcc ctaacatagt ccacactgta agattaggct gaaagctttc aactatacac     5400

cttccccagt ttgtcataat aagggcctct gcattacaaa tgatttttaa gcctcaaaaa     5460

tgacccattt acgtggaata tatatacata tatatttata tggaatatat tgctgagatc     5520

tgtacattca attactgtga atctattaca aagcagtgtg tgaagaggag aaggatgaag     5580

agatttcata tgaaggctat ctcactatct agacatttcc cgatttttct ttgtccatac     5640

atgtaaataa ctcgggcagc atcaggatgt ctcttggagt ctggaagggc aagaggagtt     5700

gccctcagtc accatatttc ttttttgact tgggctgtct ccatctggga taccatctaa     5760

tttttcctgg atgatgtact ccaaatttca aataaaagac ttagaaatga acttttggaa     5820

acctagtcaa gtctaaggtg ggaaatggct gtcaaatacg tgggcctggc ttcacaatga     5880

ataatctgta acttcttgtt ttgctctggg tagagctttc ctgtaaaggc cgctgctttg     5940

agtccttcga gagagggagg gagtgtgact gcgacgccca atgtaagaag tatgacaagt     6000

gctgtcccga ttatgagagt ttctgtgcag aaggtaagca tcacagtacc aaccaatgct     6060

tctcagtaca gccagatctg tgcacctacc ttagcatcac tgataatgtc taacacgcag     6120

tccatcttag gccttgattt tactaacata taagctattt cataataatt ttgttttgtg     6180

gagatgaatt aaagaagaaa agcgccttcc aacagcagaa cccccaggct cagccaggct     6240

ccaagagtac aagatgttgc cagaggggga acatagagga tgaggctgaa tgtatatgtc     6300

ttttttttct tcagatatgg ttcaatttca ggttaaatca acagtaatca aatcacttga     6360

tgatttcttg tctcaccctt gctgacttca cgaagtcaac tatcctttga gctatctgtg     6420

cttttggcct cagtgtttga gtatatattt aaggacataa gcaacacttt cagcttccct     6480

aaaccagtaa atttatgaat tagtttaagc cattaaattt ataggcaaat ctacctaaca     6540

cgttgttaac tgtcatgttc cttcccattt ctgcagtctc ctcagcagtc tctattccaa     6600

tacatgtgca tggtaaagtc aataacaagg gatattccca tcttaaaatc aaattctcta     6660

tttataggtc ttgaaggact cctctagagt ataacaaaag gctccagatt ttacagaaaa     6720

agattttaaa aatatacttg aatactggat tactttcctt taccaaatgg ttgttcttaa     6780

attctacttt gttaaaacaa gaatatttgt ggaggtaaaa gtgaaaataa gctttgcttg     6840

cataatcaat cttatcattt tatttaaaca agcctgcgct tcctgcttct ttagaacagt     6900

gaagaaagat cggaaaactg ctaatcagca gaattgagag atgtttctta accgttcaat     6960

gttttcatgg gaaaacattc caaaaatgat gaagacaaca cccttgtaat aaaaacctta     7020

gagctcaccc ttcctgcaga ttttagcagg ccccatgatg agtgacacat atttactcat     7080

taccctaatt gttttggctg tgagacaaga aagctaagaa tttgttttgg gcagaggatg     7140

tctagggagt gaagatggtt agaaagtgat gagacattga gagaacattt tgataaagat     7200

aatactttat gttatgaaat atttggtcag attacctaaa gtttaggtag aactctgaaa     7260

aaaaaatgat gaaggcgatg ctggccaact ttctttacag aattcataag acagtcagcg     7320

tcccaactta aaataataaa accactcaga acctcaatac ttcatttttt aagtgtaata     7380

accaaactat cttgagattc actacttagt tgtttcagta tagatactac ttacaggtgt     7440

ctatatatct aaaaatcata acatttcaag aattgaagga atcccagcca tccaagtgcc     7500

tctgaatgtg aaagagaaaa cagagtccaa gaggttaacc attttggcca agaacattag     7560

ctagtacatg gcagatctgt ttctcaaatt gagatacttg atgtttttgc tgggtaggag     7620

gagaaacaag agggacagtg gccagttcac ggagactata gcagtagggt tctggggcga     7680

tgttgcgggg agcagcatga tttatcacaa cccttctgta cccagagagt ccccagtgct     7740

gttttcttat ccttcattag tccctcttct tgttcctaaa aaaaaaaaaa aaaaagaagt     7800

tccatgtttt ctcttctaga ctgagaagcg gaaaagggaa ggggactaaa aggttaaaaa     7860

gatacacacc aaaccattaa gttgtatctt tgggaagggc agggcatttt gaggaaaagc     7920

acaatgtgaa ggtgtgaact tttcacaaga atattcatgt agaacttttg taattaaaaa     7980

aagaacaaaa ggcaaattgg catcatttaa tttaaatgaa tattaaaaca gaaaaaaatg     8040

aatactaaaa cagaaaaaaa ttctgaaggc aaagaccttc agaaatcatc ttgaataaac     8100

atcttagttt gtagacaaga agatgaagtt caagataatt atttgcctaa ggtcacaatg     8160

gtagaggctc gcaggcctag gactggaatt taggtcttct gattcctgag actttgctcc     8220

ctgtcataac ttacaacaat ttgagaacca gtattttata gcaatgcatc cttagactta     8280

aatggagtca ttcgtgttga gctggagcct gcctgcactg gctgtcacca gcatctactc     8340

ttgaagctag atgcatctgt gcttttcaca gttagagctg ctgatgaaca taaacaagat     8400

gttaactgac ttgtcttact tggcctcagt gcataatccc acatcaccac catcttcaaa     8460

gaaagcacct ccaccttcag gagcatctca aaccatcaaa tcaacaacca aacgttcacc     8520

caaaccacca aacaagaaga agactaagaa agttatagaa tcagaggaaa taacagaagg     8580

taggaagatg acagatataa tcaaaggagc tttcttagat gaagtaactt gtaggtgact     8640

gcttatctaa gcccattctc agagaacagg gtaatcttag gaatcatgag cctcattaca     8700

ctcgaaggtt ttagactttg cttttaagta aagtttaaga caaagtataa actctcagct     8760

ctttctgtat ttaccaaacc cagcatgagt ctgggttaaa acaaatcaga agggacaaat     8820

cttactataa aaaacaaaaa ccaccccatg attttctttg tagaataatt tgattctgtg     8880

ttttggagga tatgggaaag ttgagagata ctagtaatac tgctagtatc tgtgataagc     8940

ccaggtgcct tgcttttaac tgacagatta aaaggcagtt ggtcatatta ctaataaaag     9000

caaaatccag atacttgtag actagtaaat agcacttctt gctgtgttta gactggtggt     9060

tcttttttgt tttaaatcac agttggtgtg atcaaacttt ctatttgatt tatagaacat     9120

tctgtttctg aaaatcaaga gtcctcctcc tcctcctcct cttcctcttc ttcttcaaca     9180

atttggaaaa tcaagtcttc caaaaattca gctgctaata gagaattaca gaagaaactc     9240

aaaggtttga gcattgataa agatcaaaga ctgtatcaat gccatattaa caatgattat     9300

atttaaaagt aatgcgtgtt ggcagaatga ggacatctta atatgggggg gaatataact     9360

ttatgaatat tatcttagaa agtaccaaat gaatacttcc tacaggaaat tagtgccaag     9420

cggctaagaa gccactctaa aagcaaagga taagaagatg ctgtagcagg actgtggaac     9480

cacaagatgg caccagagat gattattgat ggctttctac tgtcattctt gtttacttga     9540

catcattttg cttcttctcc ttcatcttcc ttgcattttc attttccctt ccccagcttt     9600

attttaacaa acatttatat actattgttc taagtgtttt acaagtatta actcattaaa     9660

ttcttacaaa cctctatgga aaaaatatta tccatatttt acaaatcctc tttattttcc     9720

tagtaactta tatattatat ctggctgact tttcctctag tagagactgt gctacagaat     9780

aggctattat tgcctgaaaa gagatttcct ttgctgttta ttatttcctg aagttctggt     9840

tctaaatata tattctcttt ctccaggaaa tactggattt ttggataagg gagttttaaa     9900

gaactctaag aggttgtgat ttcctccgaa gcattcgctc taaataaata gccaggcatt     9960

taatctttta gtcacccaga aaatcgtgca ggaagccacc cttgggcttt gtagtccaca    10020

tgtggggcag ctgctatggg aaagccttga taaatactgt ctttttgctg cccatcacac    10080

cctaagctcc tccttatgtc ccctgggacc tgcaaggtta gctgcgcaga agaaaaggag    10140

tggctaatag ccctatgtat gggaacaagg ctcagcaggg actgtggggg tgactggggc    10200

agattgctca gaggtagctg tagaggcctc tgagataatt ggtgcagcaa gatggtagta    10260

ctaggtttcc aggaggaagg aagggacact gggcactgaa gaataagagt acaaaaagta    10320

gggggtaaag aacattaata taaacagatg aattagtgtt atttatcgtg ttggtaattt    10380

tgaacttgcc actgacttcc atgtattaat tgtatagagt tttatttgtg ctttttcatc    10440

cctcatctca tttattccct aaaacagccc aataagatag gttgagtatt tgccatttta    10500

caacaaatta aaggacatag tagagattag caatttgctt agaaacacac aactagtcaa    10560

tgataaagat gggatcttta tgtcactatt aaagaaaaaa aaatattcta aaataacaag    10620

atgtatattt tttctccagt aaaagataac aagaagaaca gaactaaaaa gaaacctacc    10680

cccaaaccac cagttgtaga tgaagctgga agtggattgg acaatggtga cttcaaggtc    10740

acaactcctg acacgtctac cacccaacac aataaagtca gcacatctcc caagatcaca    10800

acagcaaaac caataaatcc cagacccagt cttccaccta attctgatac atctaaagag    10860

acgtctttga cagtgaataa agagacaaca gttgaaacta aagaaactac tacaacaaat    10920

aaacagactt caactgatgg aaaagagaag actacttccg ctaaagagac acaaagtata    10980

gagaaaacat ctgctaaaga tttagcaccc acatctaaag tgctggctaa acctacaccc    11040

aaagctgaaa ctacaaccaa aggccctgct ctcaccactc ccaaggagcc cacgcccacc    11100

actcccaagg agcctgcatc taccacaccc aaagagccca cacctaccac catcaagtct    11160

gcacccacca cccccaagga gcctgcaccc accaccacca agtctgcacc caccactccc    11220

aaggagcctg cacccaccac caccaaggag cctgcaccca ccactcccaa ggagcctgca    11280

cccaccacca ccaaggagcc tgcacccacc accaccaagt ctgcacccac cactcccaag    11340

gagcctgcac ccaccacccc caagaagcct gccccaacta cccccaagga gcctgcaccc    11400

accactccca aggagcctac acccaccact cccaaggagc ctgcacccac caccaaggag    11460

cctgcaccca ccactcccaa agagcctgca cccactgccc ccaagaagcc tgccccaact    11520

acccccaagg agcctgcacc caccactccc aaggagcctg cacccaccac caccaaggag    11580

ccttcaccca ccactcccaa ggagcctgca cccaccacca ccaagtctgc acccaccact    11640

accaaggagc ctgcacccac cactaccaag tctgcaccca ccactcccaa ggagccttca    11700

cccaccacca ccaaggagcc tgcacccacc actcccaagg agcctgcacc caccaccccc    11760

aagaagcctg ccccaactac ccccaaggag cctgcaccca ccactcccaa ggaacctgca    11820

cccaccacca ccaagaagcc tgcacccacc actcccaaag agcctgcccc aactaccccc    11880

aaggagactg cacccaccac ccccaagaag ctcacgccca ccacccccga gaagctcgca    11940

cccaccaccc ctgagaagcc cgcacccacc acccctgagg agctcgcacc caccacccct    12000

gaggagccca cacccaccac ccctgaggag cctgctccca ccactcccaa ggcagcggct    12060

cccaacaccc ctaaggagcc tgctccaact acccctaagg agcctgctcc aactacccct    12120

aaggagcctg ctccaactac ccctaaggag actgctccaa ctacccctaa agggactgct    12180

ccaactaccc tcaaggaacc tgcacccact actcccaaga agcctgcccc caaggagctt    12240

gcacccacca ccaccaagga gcccacatcc accacctctg acaagcccgc tccaactacc    12300

cctaagggga ctgctccaac tacccctaag gagcctgctc caactacccc taaggagcct    12360

gctccaacta cccctaaggg gactgctcca actaccctca aggaacctgc acccactact    12420

cccaagaagc ctgcccccaa ggagcttgca cccaccacca ccaaggggcc cacatccacc    12480

acctctgaca agcctgctcc aactacacct aaggagactg ctccaactac ccccaaggag    12540

cctgcaccca ctacccccaa gaagcctgct ccaactactc ctgagacacc tcctccaacc    12600

acttcagagg tctctactcc aactaccacc aaggagccta ccactatcca caaaagccct    12660

gatgaatcaa ctcctgagct ttctgcagaa cccacaccaa aagctcttga aaacagtccc    12720

aaggaacctg gtgtacctac aactaagact cctgcagcga ctaaacctga aatgactaca    12780

acagctaaag acaagacaac agaaagagac ttacgtacta cacctgaaac tacaactgct    12840

gcacctaaga tgacaaaaga gacagcaact acaacagaaa aaactaccga atccaaaata    12900

acagctacaa ccacacaagt aacatctacc acaactcaag ataccacacc attcaaaatt    12960

actactctta aaacaactac tcttgcaccc aaagtaacta caacaaaaaa gacaattact    13020

accactgaga ttatgaacaa acctgaagaa acagctaaac caaaagacag agctactaat    13080

tctaaagcga caactcctaa acctcaaaag ccaaccaaag cacccaaaaa acccacttct    13140

accaaaaagc caaaaacaat gcctagagtg agaaaaccaa agacgacacc aactccccgc    13200

aagatgacat caacaatgcc agaattgaac cctacctcaa gaatagcaga agccatgctc    13260

caaaccacca ccagacctaa ccaaactcca aactccaaac tagttgaagt aaatccaaag    13320

agtgaagatg caggtggtgc tgaaggagaa acacctcata tgcttctcag gccccatgtg    13380

ttcatgcctg aagttactcc cgacatggat tacttaccga gagtacccaa tcaaggcatt    13440

atcatcaatc ccatgctttc cggtattaag aatcagttat tttcattttt aaagctggta    13500

atgttagttt acatctatct gaaccagaat gccttagttt agtatcactc aactgagata    13560

tattacctga ccttgttagc ttgtgaagtt ttacagcttc cctgtaggta agcagaggtg    13620

taattacagt aagctttttc attctctaga aaattaagcc tgggaattta gcatatgtgt    13680

gtctgtgagc agcagagatg gtatatagaa agtcaaaaaa atttagttcg gagtctattc    13740

ttaaaagtac aatgcaaagc aaaaatctgt agtatcattt tccaaactaa cccaaaggga    13800

gggcaatcag aactgaaaga tgcaatttca cattgagttc atacatccaa aaaatgtcta    13860

gtttacatga aaatcaaggt aacctggtcc attccaattc ataataattt atttcatata    13920

atacttttga agagtatcat ctttaagtaa aatggaatta tcaagtatat aactatgcaa    13980

acaggtcaaa ctgtgtcctt caagatctta gaaaaggtaa acaggaaata gaaccatgtg    14040

gaaagacttg aaaagaacat acagactttt ctcattctgt tctatatttg ttttgttttt    14100

gttaatttgt ttagatgaga ccaatatatg caatggtaag ccagtagatg gactgactac    14160

tttgcgcaat gggacattag ttgcattccg aggtgagcta tgtacacatt tatttttctt    14220

ctcatcattc tgttttggca tttatgagaa ccaaagccgt ggaagagtgc tagtttgggt    14280

tgttttctgg aggggaatct gattgataag cacacctcac aggagaatcc gagagtaata    14340

acagaaatat tggattaaga aaattagaca aagtaacaaa acaaaaccaa gaccctgaac    14400

tgatactact gaggtttttt cctactgtta agatttaaaa agtagttcat tttttttggg    14460

gggggggggt agttaaaatt taaaaaataa aataaaattt taatttcata ccaaatgaaa    14520

tgacaccagc atgcatattc actgctttat ttgaaaataa catctcaatt gtgatgtgtt    14580

caagtgttac actctctgtc ggagagtaac agaagaaaag ttatttcatg ttaattctct    14640

gctgtactct gctagtccag tcttgaaaca tatttagatt aaatctgaaa gcaattcctt    14700

ttcgtacagt agaggctaaa gagatgttag tcattaaatt ataattcctt agttctaaga    14760

gataaagaaa ttgagatcta aagagatagt gactgtaagt cacaaagcca aaaggctttt    14820

ttgagaccgg atctccctct gtcacccagg ctggagtaga gtggtgcaat tacggctcaa    14880

tgcaggctcg atctcctggg cccaagtgat cctcccatct cagccacctg agtagctggg    14940

actacaggtg tgcaccacca tgcctggcta atttttgtat ttttttttgt attttttttt    15000

ttttgtagag acagggtttt gtcatggtgt ccacgctggt ctcaaactcc tgggcccaag    15060

ccatctaccc gccttaacct cccaaagtgc tggattacag gtgtgagcca ctgcacctgg    15120

cccaaccaat aggctctttc taaagaaact agaaaactaa agtatctcaa aggttatgct    15180

aaatttcgga cttgggaaat acctgctctc agaaatgttc aaatactacc ttttgtatct    15240

gactaaactt ccagtcatac aatgcataag aaaactacat tttttttcat tttggtttct    15300

tttgtgatag gtttagcatt cagcttgtag gctgatgtct ttccttaaat tttaggtcat    15360

tatttctgga tgctaagtcc attcagtcca ccatctccag ctcgcagaat tactgaagtt    15420

tggggtattc cttcccccat tgatactgtt tttactaggt gcaactgtga aggaaaaact    15480

ttcttcttta aggtaacaca aatatctttg tgagagaaat ttaataataa tttgtaactg    15540

cattatttat tacaacatat attgccttaa cctccaatat gtgtcctttt aaatactctg    15600

tcatcaaaat ttaatcataa ttcaacagtt tgataacagt aatggtcaaa attcaaccgt    15660

ttaaccaagt taacacgttc tctctatact taaatctaga aaggagttcc aaatcttttt    15720

tcccaaagct gataacataa ttttctcttt taaattatca ggattctcag tactggcgtt    15780

ttaccaatga tataaaagat gcagggtacc ccaaaccaat tttcaaagga tttggaggac    15840

taactggaca aatagtggca gcgctttcaa cagctaaata taagaactgg cctgaatctg    15900

tgtatttttt caagagaggt atgtgttaca taattgacaa gattacaaaa cttttaaaga    15960

attacactca gcattttcat ttattattga ctttactgtc aaaagatatc tttaatggct    16020

gaaatcaaat attttcagtg aaaaaaatca atattgaggg tagtattctt attgccctca    16080

atttttattt tcatttcttc acaggcaagt cacaattcat ttgagttttc aggtcactga    16140

tagaatgtca tttactttcg cttcacaaat gtgcatgtca tccttgcaca agggccatgc    16200

taatctctgt atcattccag ttttagtata tgtgctgcca aactgagcac ttgtcacttt    16260

caattgaaat taaatatata actatgtaat ttgctgcatc tattcattca acaagtattt    16320

cagtttaata attattttta taataccctt gactaatagc cattattaat atcaatatat    16380

tatatgaaaa atgagaacaa aactgtttcc tatacattgt aaaagttgtt ttccaccttt    16440

tctgagggta ttaaaattaa ttttcatttt ccatgtgata ttctaataca taacaggtgg    16500

cagcattcag cagtatattt ataaacagga acctgtacag aagtgccctg gaagaaggcc    16560

tgctctaaat tatccagtgt atggagaaac gacacaggtt aggagacgtc gctttgaacg    16620

tgctatagga ccttctcaaa cacacaccat cagaattcaa tattcacctg ccagactggc    16680

ttatcaagac aaaggtaaca tttttattgt gttaaaaaaa tccttaaaca taagtagatg    16740

taatacagtt tcttatacag taaggcttat gaaatatgga tactgatcaa acagccctaa    16800

taatttaagc ttactgatga aaaactcatc cacttgcctt agtgaataac caaagaccaa    16860

tactttcttt ttccttgtgg gtaagtaaag cagtttgttc aggtttgtta gttataacca    16920

atactattta tcaagtactt cttaccaaga acattatata ccagtctata accctcaata    16980

gttctacatc agagggctaa aactgagatt aaaactcaga tgtctggctc tttccaagat    17040

agtacattgc cttttaatct ggtatctttt attaaacatg ccacttacag gtgtccttca    17100

taatgaagtt aaagtgagta tactgtggag aggacttcca aatgtggtta cctcagctat    17160

atcactgccc aacatcagaa aacctgacgg ctatgattac tatgcctttt ctaaaggtaa    17220

ggtattaact aacagtttcc caaggaggtg atatcatttg tgaaaacatg aagataaagt    17280

aaaaatgctg gctgcaatga tgactgaatg tgagaagtta cactacggta cttattctaa    17340

ttgctgtgga aaagagttaa gacttttgct ttaatttcaa ttaaaatgat ggcactgcaa    17400

ttcaattctg ctctaacctt catgagatta cgataaaaca tccagttact agagtaaact    17460

tgctactgac aatagtattt tacttctatc atttgtggca tttaacagat accttgtttg    17520

gcacaaggtt ataatgattt gcatcactgc agagtctgta agatcagaaa gaagttcctg    17580

agaaactaat tttattaatt aaattatatt actcaggatg cttttctttg aaatgcccag    17640

aaatctaagt tattctgcct gtaatttcat aatatgaatg acattggcat gtatttttta    17700

aaaggaataa ccccaagtaa attatttttc aaacttggtt actctttaat gtttacttca    17760

taaaggagag ctgaacctga ttttacaaaa agatggtgaa atgtcaatct tttgaaacat    17820

caaaaaagct gaaaagtcta ggcaattgtt tttctttttg ttataaagtt caaattaatt    17880

agtaaaaaca tctctattaa aatgataaac attgtctttg agcataatag tcaacataag    17940

ttatttttta gtttgggcat tgttttcttt ttaactaaaa aaatgttttc tcttccattt    18000

agatcaatac tataacattg atgtgcctag tagaacagca agagcaatta ctactcgttc    18060

tgggcagacc ttatccaaag tctggtacaa ctgtccttag actgatgagc aaaggaggag    18120

tcaactaatg aagaaatgaa taataaattt tgacactgaa aaacatttta ttaataaaga    18180

atattgacat gagtatacca gtttatatat aaaaatgttt ttaaacttga caatcattac    18240

actaaaacag atttgataat cttattcaca gttgttattg tttacagacc atttaattaa    18300

tatttcctct gtttattcct cctctccctc ccattgcatg gctcacacct gtaaaagaaa    18360

aaagaatcaa attgaatata tcttttaaga attcaaaact agtgtattca cttaccctag    18420

ttcattataa aaaatatcta ggcattgtgg atataaaact gttgggtatt ctacaacttc    18480

aatggaaatt attacaagca gattaatccc tctttttgtg acacaagtac aatctaaaag    18540

ttatattgga aaacatggaa atattaaaat tttacacttt tactagctaa aacataatca    18600

caaagcttta tcgtgttgta taaaaaaatt aacaatataa tggcaatagg tagagataca    18660

acaaatgaat ataacactat aacacttcat attttccaaa tcttaatttg gatttaagga    18720

agaaatcaat aaatataaaa tataagcaca tatttattat atatctaagg tatacaaatc    18780

tgtctacatg aagtttacag attggtaaat atcacctgct caacatgtaa ttatttaata    18840

aaactttgga acattaaaaa aataaattgg aggcttaagg attagaaaac ttgttccatt    18900

tattactatt ccacattcta tcatgtaatc cagttatgtc agaaattcac ctctctgtct    18960

gttaaactga cgaccacgga caccttgtct caatgttgtc tgaagtctta ctcgtctgaa    19020

aggctttggt tgactactac tagtatctaa gaaaaacatt aagataaaag aaaagcaagt    19080

gaaaaaatga gaaagcattt ataatgatac aaactaatta ctaaatgaat gaatgaataa    19140

gatgtagact tgttcatttg atttcaattc tttttttcaa acaatgagga acatttaaca    19200

aaccgaaaaa gggtaaatgg ttaaacaaca aaaaaagcag cactttggga ggctaaggtg    19260

ggaggatcac ttgagctcag gagttcgaga ccagcctggg caacacagcg agaccctgtt    19320

tctacaaaat tataaaacaa ttagctgggc atggtggaac atgcctacag tcccagttac    19380

tcaggaggct gaggctagag gatcacttga gcccgggtga ggttgaggct gcagtgagcc    19440

atgatcaagc taacagtact ccagggagac cggtgagatc ctgccttaa                19489


<210>  8
<211>  13649
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated epx gene sequence; mutated base: chr17:58193733 (G->C); 
       mutated codon: caG->caC;

<400>  8
gcaccttgga gggagtgagt agggctaggg gataaggaga ggggccaaat cattcatcac       60

agatcattca ttcactcaac aaacacctgc taagcacata ctaaatgctg ggctttgagc      120

tgggtatggg gggtgtgtat aacagtaagg cagattcagt ttctgccctg ttgcaggagg      180

agaggcaccc ttccaatcat ctggcccaac tctcattcta gggatgtgaa aactgaggcc      240

tggagaggga aagtggcttg cccaaggcca tgcagccagg cggtggcgac tgaggtgcac      300

cgctcctgtc agccaacaaa tatccattga gcgacacctg tgtcccaggt gctgctctgg      360

gccctgggag aagtgcatca gtgggcttgg tagtagaggg tagggatgga gtgaagggta      420

ggcaggaaga atgtccccag gctggtagga ggtggggtgg ggggtttcag tctcaaaact      480

cccatgaaaa ccagagagaa gtttcagaac tccacccaag aggctgggtt tctagggccc      540

agagctgccc tcccccaccc tagaatgggc tataaaagtc ccttcccagc tacgtccaga      600

gaagagctgg aggaagtgag aggtcggctg ggggtcctca aagtgagagg ggagcagagg      660

atcctcccgt gcaggctgtg gatgtcactc acttcccagc tggtgaagcc tcgctgcaga      720

gatgcatctg ctcccagccc tggcaggggt cctggccaca ctcgtcctcg cccagccctg      780

tgagggcact gacccaggta atagtcccct agacaggcaa ggaggaggga ggggaaatgg      840

aaggggaagc acttgggtct tggagggggt cttgtggctt gctgaaccct gagtccccat      900

ctctttgaac agcctcccct ggggcagtgg agacctcggt cctgcgagac tgcatagcag      960

aggccaagtt gctggtggat gctgcctaca attggaccca gaagaggtgg acttgggtct     1020

gggggctgca tgggcctggg aggatcagtg aggggcatgg gccccagcca agttcatctc     1080

actcatcagc cacctctgga ccccatgaac atttcctgtt ggtagagcct cccttccatc     1140

catccttctg tccgcttgcc ctgtcctgac tgtgccccag gactgggtct ctgctgggtg     1200

ggtctgcacc ctctctccag ccctcactcc tcctctcctg ggcagcatca agcagcggct     1260

tcgcagcggt tcagccagcc ccatggacct cctgtcctac ttcaaacaac cggtagcagc     1320

caccaggaca gttgttcggg ccgcagatta tatgcatgtg gctttggggc tgcttgaaga     1380

gaagttacaa ccccagcggt ccggaccctt caatgtcact ggtactctga tccccactga     1440

gcccgctggg cctaccctgg cctggagtag aaggaatcca ggagagggag gcagggtgca     1500

caggtttggg gtgctgggag gagagagggt aaagggatgg gaggtacaga gcaggccagc     1560

tcaggtctgc ccatttgcct tcccacagat gtgctaacag aaccacacct gcggctgctg     1620

tcccaggcca gtggctgtgc tctccgggac caggccgagc gctgcagcga caagtaccgc     1680

accatcactg gacggtgcaa caacaagtgc gtgcggggcg gcaggagggg ctgcccctgc     1740

ctgggggacc tctcccttcc tgcacccacc ctctccctcc atgctgagcc atctccaggc     1800

cctgccccct gctaacctat cccacccatg gctgcaggag gagacccttg ctaggggcct     1860

ccaaccaggc tctggctcgc tggctgcccg ccgagtatga ggatgggctg tcgctcccct     1920

tcggctggac ccccagcagg aggcgcaatg gcttccttct ccctcttgtg agttggggct     1980

gagggtttgg gaggttgctt gatctcttaa atgcggggag taaaacacag cccagagtca     2040

cgcaggcagg gcttgaaccc aggcccttcc actgaccagt gcagtgactt gaggcaaata     2100

acacagcttt ctgaggctta gtttcctcat ctgtaaaatg gccctaaaac ctacctcgta     2160

gagcctgtgt ggatattgaa gtccttggta taaatagcta tagaggacat gatctattca     2220

tgctaaccat tacggtgttg tacggttttt tctgagaaaa ttagtgtcaa agtcttgcta     2280

aatataaaca gctctatacc ttaatctggc tttatctatt gatctatttc acatttatca     2340

actcatcagt tttctattga tatatcgata gagcagtcta tcatctaccc atctatcaac     2400

atctattaat taattttctt ctatccaccc ttccatctgc tgaccccgta ctccctacgt     2460

gtattatcca tcacctggca accagcccat gcacctgtga atccgtgcta tcatctggtt     2520

agctatcagt gtacaaattg atctatctat ttgatctccc ttcccctctg ggagagctgg     2580

tgaggtctga gccagtcaac ctagcccctc tccttctctt taccaccgga atcctcagga     2640

gcccagccag aaaccatcct tctaggaatg agagcaggag gtggctacgc ctccagggac     2700

aaaaggggca tggagggcag aagaggagag gctgtcaatt ccagcagggg agctgctgct     2760

ccctgagtcc tgggttggct ctaatacctt gtggggtcag ggagcccatg tcccgtgctg     2820

atgttatttc cccaccaggt ccgggctgtc tccaaccaga ttgtgcgctt ccccaatgag     2880

agactgacct ccgaccgtgg ccgagccctc atgttcatgc agtggggcca gttcattgac     2940

catgacctgg acttctcccc ggagtccccg gccagagtgg ccttcactgc aggcgttgac     3000

tgtgagagga cctgcgccca gctgcccccc tgctttccca tcaaggtacc taccctcagc     3060

caatctccca tgcccttgtg tggcctcccc caaaggcaag gtgctggggg tggggatctg     3120

gaagactgga gcaccatcct taaggagctg cctgtggagc tagggtatga gacagagaca     3180

caagaaacac agctgagcag agaccccgcg ccgtgtgtgt ttgagaggtg ggggtagggc     3240

aatctgccag gaggctcagg tcaggcttca tggagtggga agcccttgac acatgccttg     3300

acccatgggt ctgaatccaa caggggaagc ctctgggccc ctgcttttgg caacctaagg     3360

gcctcttagc tcttgccctt ctctccttcc cagagtagtc caagggtcct gcggctcttg     3420

ccagcttctt gggcttgggc tgtaagtagg gtcctaacct tcaggctaga agccaaggac     3480

agtgtggggc actaggggag gaaagataga atccagggag cagagtctct gctaggaaca     3540

tagggttgac acacgtgcac acacacactc tctcacacac acacacgtgc acacacacgc     3600

tccctctcac acacacatgt acacacacag tcacccttaa taggtggggc cacattcatg     3660

agggatgaca tgtgagggcc tctggatggc ctctccctgt tgcaacctta tctattcctc     3720

aatccctggc ttaggggcac ctcctctggg gagccttctc agatcttcct attacacttt     3780

taacatatgt cctcccctcc cctctcctct ctctccttcc ttccttcttc cttcctcttt     3840

ctttctttct tctttctttc ctttccttcc ttccttccct tccttccttc atttccttcc     3900

ttcctttctt tctttctttt tctttctttt tctttcttcc gtcctttctt tctttatctt     3960

tccttctttc tttcttcttt attattatta ttattgtttt gagacagaat ctcactctgt     4020

tgtccagact ggagtacaga ggggcaatct cagctcactg caacctctgc ctcctgggtt     4080

caagcagttc tcatgcctca gcctcccgag tagctgggat tacaggcatg tgccaacaag     4140

cctggctaat ttttgtattt ttagtagaga ttgggtttca ccatgttgac aaggctgatc     4200

tcaaacttct ggcctcatgt aatccacctg cctcggcctc ccaaagtgct aggattatag     4260

gcgtgagcca ccacacctgg cccacatatg gcttttctat caagcacagc agatgccact     4320

tcaacttagt ttcttaactc tatgtgtgtg tgtctttttc cactgaactg ccagcttcct     4380

gcaacctttc ctgtgttttt ttaaccttca taatctccaa agcagcaagc aagaaagggg     4440

cttagaaaag gtctgtcgaa ttgaacagaa ttaaagaagc tcaggcctaa gagtcaagag     4500

aactaagttc taatcccacc tttcctgcta actggttgtc acttcccctc tctgaggctg     4560

ttttccttgc tgtaaaatga ggatcgagat tgtttcaaaa gcctcattca ttcctaacct     4620

tttgagactc tatgaaacaa aatgttaagg acactcagac tgacggggtg agcagcatga     4680

gcctgggtga gtcaaggagg gcttcctgga ggaagggagt tttaagcaag gttttgagga     4740

ggtggaagat gacggagagg agtgagtctg ctattgaggg ggccccatgt cactgtctcc     4800

tcttccatct cagatcccac ccaatgaccc ccgcatcaag aaccagcgtg actgcatccc     4860

tttcttccgc tcggcaccct catgccccca aaacaagaac agagtccgca accagatcaa     4920

cgcgctcacc tcctttgtgg acgccagcat ggtgtatggc agtgaggtct ccctctcgct     4980

gcggctccgc aaccggacca actacctggg gctgctggcc atcaaccagc gctttcaaga     5040

caacggccgg gccctgctgc ccttcgacaa cctgcacgat gacccctgtc tcctcaccaa     5100

ccgctcggcg cgcatcccct gcttcctggc aggtcagaca gggaggaagg tggtgtcttc     5160

ccaggaaaca gccatccctg gggtcccaac tgggaagcaa tggtgggatg tggtgaaggt     5220

acatggtttg ggacctcagt attaggcaca ccataagcat ggatctgtgc acagccatca     5280

tagaatcaga acgttgagtc cctttgcaag ctccctgtgt gtggccagag ataactgctt     5340

aaccgtctcc agtgacaagg ctctcaccgc ctctatggca ccccagctca gccacaggca     5400

gctccgactg ttagaaagtc tccttatttt gatcacatat tcacctattc cccttaatca     5460

tgcttctgga acctcagaaa agacactgtc cctcttacac gcaggaatac ctcaaagtag     5520

ctgttaactc catctccatt ttttttctct tctctgggat aaatttccgt agttcctccc     5580

tgtccccagc tgttgctaga cagttaatac cctcttctgg aagcataatt tgaactttcc     5640

tcagggtctt ttgtcccatg tacatggtta caataataat ggtagtcatt tctcattaag     5700

atatttatct tattattatt attattttaa gatggagtct cactctgtcg cccaggctgg     5760

agtgcagtgg cgtgatctca gctcactgcc acctctgcct cctgggttca agtgattccc     5820

ctgcctcagc ctcccgagta gctggaatta caggtgcctg ccaccacgtt tggctaattt     5880

ttgtatattt agtggagata gagtttcacc atgttggcca ggctggtctc gaactcctga     5940

cctcaggtga ttcacctgcc ttggcctccc aaagtgttgg gattacaggt gtgagccacc     6000

acgcccaacc ttatcaagat atttaaatgt gccatctcta aaccttgcaa cagccctgaa     6060

aggagggaat tattattgtt ctcattttac gataagaaac tgagactcag ggaaagtgaa     6120

tcatgcgccc aagagcacag agttagtttc aaatgacaga gtccacttga gaacacagtc     6180

agtgtagtat caaggtctct gcccagtcca ctgtattcca ctgttttcct cacagagagt     6240

cggccccaac ccctcttttg aaggattgta catttgtgtg tcctggaaag agcagcttgt     6300

gccttcggga gaggtcaact gaactaagac cttgtgcaaa agggtttagt taaaaccaag     6360

caaatgatgg aattaacttt ctttccctgc ctgtagtagg tctgttcgta aggacagtct     6420

ctgcccaacc ctccctctct tcctctttcc ctctggttca cgggggagag cagtattata     6480

ccaagcccaa agataggaag aggtacacca gcccttggca gagaacacgc aggcagatgc     6540

agctcatgga caggtgggct ctcagtccca aagtcaaggt gcccttgccc atagctggtc     6600

caggctatgg atctggttgt cttgtagagt agaatcctta ggcaaagatg cccctgcctg     6660

agaccagcag ctgccctgtg ctttcccacc tcacccaagc ctgctaggaa cccccggtcc     6720

ttccgctcct ggcctgtggt gttagggagg agggtggcga tgaggagcct cagcacagct     6780

gaagagatgg aggtccagtg agggccagga gtttggccca ccccgtctct cccatcccca     6840

gccctgggtc taccctggta gaaagacatt tctctgggaa aggctgcagt aaatctgagc     6900

ttggggtttt caaggtgaca cccgatcaac ggaaaccccc aaactggcag ccatgcacac     6960

cctctttatg cgagagcaca accggctggc caccgagctg agacgcctga atccccggtg     7020

gaatggagac aaactgtaca atgaggctcg gaagatcatg ggggccatgg tccaggtaag     7080

gagctctgca tcccagcatc ccccagatga caagcttggc atgagaagca gtccttaaca     7140

catccttgcg gatgtgccta aaaccagctg ggtctgggca actggcggag cacctggacc     7200

tgtcctctgg ccccgattct gcctctaact cccgtgtgac cctgtctgtg tcactcaccc     7260

tctctgggct ttgtatctcc acccaccaat agtaaattaa tgttgtcaca tttgacgtga     7320

tgacaataaa gaatatgtct gagccaccct ttgaaaaggc aagggtatgg gtgagtagcc     7380

tctggggaat gttcctcctg tcttcccttc cagatcatca cctaccgaga ctttctgccc     7440

ctggttctgg gcaaggcccg ggccaggaga accctggggc actacagggg gtactgctcc     7500

aatgtggacc cacgggtggc caatgtcttc accctggcct tccgctttgg ccacacaatg     7560

ctccagccct tcatgttccg cttggacagt cagtaccggg cctccgcacc caactcgcat     7620

gtcccactta gctctgcctt ctttgccagc tggcggatcg tgtatgaagg tgaccaggtt     7680

ttccaggggg caaatggggg tgagggtggg gagcatgccc tcccctaggt gggccaagct     7740

tactgccagg aagccaggct gctgcagagg ccactgctaa tatctcccca ggacagtgga     7800

aacaaggcag gtgccagcaa gaccctcagt cacgggcctc ccatcctgtg tggaatgaga     7860

ggatttttta aaggggtgga gactaatgtc agattgatgg ggagctcacc ttccattcct     7920

taagaagtac ctcccagctc cagctgcttc atgtctctcc agaactctgt ttcctgacaa     7980

acgttactaa catacccgac tggcttgtcc agctctgggc tagcttggca tcatgtgata     8040

acccaagtag cttcccagag gctggtccaa tctgtgctgc tcacattccc tgccaccagg     8100

gggcatcgac cccatcctcc ggggcctcat ggccacccct gccaagctga accgtcagga     8160

tgccatgtta gtggatgagc tccgggaccg gctgtttcgg caagtgagga ggattgggct     8220

ggacctggca gctctcaaca tgcaacgaag ccgggaccac ggccttccag gtgagggggc     8280

tgtccacctc ttctcccagc tttgctcggg ccaggctgct caaggggttc tgggaagacc     8340

ctggtacctc ctttctgact gggactgtct acaggatgtg caggagtgca gaggcatgca     8400

aggccaaggt cgatgtccca aagcactcct ggaacaccgc ttgctgtcct gccatggctc     8460

ccccatccac tgtaggggct ccagctttag gttcaccaca ggaccagcac ttaggctcag     8520

gagctgaaaa agggaggctc gaactttcca agtagaaaaa aagcaatagg cttaaaaggc     8580

agggaagaac tgctccattc ccaacacgct ggcaagttcc aaggaggaag gctaaaattc     8640

cagagctaca gaaacgctcc ttgctctaag tggagaaagg caaagagcct tagaggcagg     8700

gaataggtgg aataaaacta aggctgcagt ggctgtttgg tgagggcaca aatgacttta     8760

tcccaggaaa gaagaaaata taggcacttt gttagtcact ttcatgtata ttaatttatt     8820

ttgttctccc aatcaccttg agaagcaaat gattacagcc attttataga tgagaaacta     8880

tgttcagaga cagctagtaa tttgcccaag atcacataaa taagaagtag taaaatctga     8940

atttaaattt acaatttctc ctttcttccc cctgttcaac cccagtaggg gaaggttttg     9000

gccactgcct tgctcctctc tccttcccac ctcctacctc cctgtctaga aagaacctga     9060

aggcccatct gcccatgtat gaagcagtgg tggcacctcc tactgcccac cccacttcac     9120

acagcgcctg gtagagcaca gcaggcactc cggaaacctg agcttctttc ctttcttaaa     9180

cttgggcgct cctggcagct aaggagctgt gggcaccccc tgccggagag ctgagatcgc     9240

tagccaccca agtttctatt aggttttgaa gggaaggcaa gggttaagga aagacacaaa     9300

gagagagggc ggctgaacag ccaatgcagg tatttatttc cagcataaaa cctacagagg     9360

tgggggacca gcttattgcc agaacctgcc gccgcctaca gctggggtac tgggtatggg     9420

tatgggtatg ggcaggaggg gtctgggtcg tatggcttgc tacccagcag gatattgata     9480

agatgtacct atgatcaggt ccttttttca gtgggatgtg gtaagatgtt ccttggacct     9540

ttgcccagca ggatatgata gggatgttcc ttcagttggg cctttgccca ttagggtatg     9600

ttatgttttt catggcccga cctcctgtgg aacgtttcac tttgaccaag gtctgggaaa     9660

tggtgggggg cttagaaaat ggtgcagttt ggactaacat tcttgccttc tactttggta     9720

taaaaggaag agctggagag ctgagatcgc tagccaccca agtttccaca ttgcgagctt     9780

ctgctccccg caatacctgt gccctccaga aatattatcc tgacactagc tcttgcaatc     9840

tcctctaatc ccttcccaag tccaacatca aactgggaac tggacaacct ggtttgagct     9900

ccacttaaca gtaaagtgac cctgaagcct atggttgctc aactttagta aacataccag     9960

atatagttag catgccataa aagcacctca aaaaggtgct gtgagggtcc tgagatattc    10020

acccaatagt gctcagtaat ggtaaaatac tgtgtggttt tcatgggttc cgctggggga    10080

tggtgtgtgt gagctgtagt tcaatggatg acgttgggct ggtgtccctt cgggacatgg    10140

caaagctatc tcctaccttg attgtcacat cttatgatgt ggcttggccc tgcgtgggat    10200

cctgatggct gacaaattgg tatggcttgt ctttggaagt ttctgaaaac tttttaaaaa    10260

cttctttatt gagatatacc ataaaattca cccatatgaa atagacaatt caatgatttt    10320

agtgtattta gagttatgca cccatcacca tgatctaata tcacaccatt ttcactcccc    10380

aaagaaacct tgtaagaaca gtcaatcccc atccccaccc cagccccaat cacctctaat    10440

atactttgtg tctctatatt gacctatgca ggacctctca tatcaacaga atcatagtgt    10500

gccgtccttt tctgagtaga tgaattttat cattgctctc catttgtttg cttgttcatt    10560

catttattca tttgctcact cattcattct acaaacctga tggagagtct tttatattct    10620

gggtactgtc ttacttgtgt ctaatgaatg cagtcgagcc cagtaatatc actaagtgtc    10680

ggatttgtgg ttatgagttt tgggttaaaa cagcttttta ggttaggaca cactcctcag    10740

tctgatgcac actgagcaca gttgtccact cacattttca atcagaggac agaaacctag    10800

tctttggaag ctctagggac tcttctgcca gcaggatctt ctggttctgc ccaatattga    10860

ctggccacag cttcccccca gaggactggt ggagaaaaac agaagctaat gggagatcag    10920

caagactgaa gctgcttctc cccgttcccc tgcagggtac aatgcttgga ggcgcttctg    10980

tgggctctcc cagccccgga atttggcaca gcttagccgg gtgctgaaaa accaggactt    11040

ggcaaggaag ttcctgaatt tgtatggaac acctgacaac attgacatct ggattggggc    11100

catcgctgag cctcttttgc cgggggctcg agtggggcct cttctggctt gtctgttcga    11160

gaaccagttc agaagagccc gagacggaga caggtaagtg accctatcat aaaagacatc    11220

agcaccagag gcagagcaga aaaacactag catttcaaga ctaaacattg aagaacactg    11280

ctctttttag tatcatttct tccaagttca caggatctga aatcaggagg ctcctctctg    11340

aaaagctggg tcaaaggaag agagacactg acccaggcaa ggcccatatt gcctgagctg    11400

gagtcatctt aaacccagag gttgcctggc agcctcacta ttctgggttg gtggatccca    11460

gaaaacatgg gcagaaaggg ctaaatctgg tttccctcca atacatttgt gatttaagac    11520

ctgacggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg    11580

gcggatcacg aggtcaggag atcgagacca tcccggctaa aacggtgaaa ccccgtctct    11640

actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcc cggctacttg    11700

ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt gagccgagat    11760

cctgccactg cactccagcc tgggcgacag agcgagactc cgtctcaaaa aaaaaaaaaa    11820

aaaaaaaaaa aaaaaaaaaa aaaaagacct gtctccttat ttggagttgg tattgcccga    11880

gttcaaatcc agccctggcc acttaaatta ctgtgcactt aatactgggc aatttatttg    11940

gccactgaat ttgtttcatt tctgagattc caatcttgca ggaattttgt gagaattgaa    12000

tggaataata tatgtaaagt acctggcaca caacaggtgc tcattataag gtaattcctc    12060

cccagccttc acccacatct ctcgactgcc tggtaggttc tggtggcaga aacgaggtgt    12120

tttcaccaaa agacagcgca aggccctgag cagaatttcc ttgtctcgaa ttatatgtga    12180

caataccggt atcaccacgg tttcaaggga catcttcaga gccaacatct accctcgggg    12240

ctttgtgaac tgcagccgta tccccaggtt gaacctatca gcctggcgag ggacatgagg    12300

cttctgcagg taaggggagg ccacctccag caccctgggc tgggttaagc cctcacatcc    12360

ttccctggat ggatggctga gtcctcttag gtctctaagc agagaaaaca gaacttgtca    12420

ctaggtactc tttccaagtg gcttcccaat gtgctagttt ctgggctgac agtcaattcc    12480

aggccctagg actttggggg gaaattagga gcatccaact atcctcagct tggtcactaa    12540

tacctgaaaa cagctccatt tctaaacatc cagtaaattc ctgacttatc cagttctgtt    12600

acttccacag gagtctatcc caagtctcca acttttggag acaaggggaa ggggaggacc    12660

atgaggctgc cttgtctccc tggagcaagt gcaggctgct gacgcttctg ctggctacag    12720

ctcagagctg ggttccccag ccaggagtga aggctggggg ctcctatcag caatggacct    12780

tcccgccttg ggagcctctt aggtattagg ctatgaatca gcgccacgtg caaaggcttg    12840

ggagccaagc catgtggtct tgcaccccag gcaagaaaag tcagctggag ggtttacagc    12900

actttctact gtttcccagc cctccctccc ctccctcacc atgactaaga gaccactcgg    12960

tcctagcctc cagacacccc acaatactcc tctgagcctg aggccaggca gcatgctctg    13020

cttctaccaa taaagcactg ctaagggcag gggctgctgt ttctgtgttg ggctagggaa    13080

gacgtggcct cagttccatg ctttgctcca gatgtttaag agaagtgctg ttaacacgca    13140

agctggcaca accatctaag cctctcctgg gggctgaatt aggagagccc aaagaaacac    13200

tgtggagtag ggaaaggcag aaaaggggaa gggcagacat ggtaggggcc ccgacattaa    13260

gaacacccta gccataccag caacctgagc agacaaacag ccaacagaac atcagtcaaa    13320

ataaaagggg tttatgtaac aaaaaacaaa aaaacaaaca aacaaaaaaa cacagtaaaa    13380

gataccaccc agctagcaga aaggactcag cactgccttc agccttcact tactcagaaa    13440

taactcatat ctcaacctca gcaagcccca agcagtagaa tgaggcttcc ctggaaagag    13500

gctgagactc acaggctggg gatttaagac cctctcaccg tccaccttcc ttccttcttt    13560

ggtcttggaa gatgaaaggc tccattttta aagggtggag aacagcagat cccctgctac    13620

tgtgagacaa gccagaaaag tgagtcaag                                      13649


<210>  9
<211>  28057
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated PON1 gene squence; mutated base: chr7: 95316772 (A->T); 
       Mutated codon: Atg->Ttg;

<400>  9
gaagacgttt tgtcctgttc tgtagcatct agaacagcgc ctggcacata gtaggtactc       60

aataaatgcc agctgcatga ggaaatgaat gagctgtgtg ggggatgtac ttgagtgaac      120

tctaaagtca gagtggtgtt gagagaaaaa tgcttgaaat ccagatgttg gaaggtgaca      180

cagagtagta gcctggtgag aacagttaga tcttaggggt tcctactaca gccctccctt      240

ccgcaccttt ttggctgtca ccatgatcaa gctactgaat ctctctgaga cgcaaggacc      300

gggatggcac aaagtgagtg ctcaccaaag cttgactgtc ctttcccatg gcaatttact      360

tcagcttgtt tgatttcccc tccccgactg gactaggcac ctattctctg tcttctctct      420

ttacagttgg aaggagcaaa atgggacttt tggctgaaag tgctgagctc ctgcggtggg      480

ggctgaccgc aagccacgcc ttctgtgcac ctggtcggcc cagctagctg ccgacccggc      540

ggggaggggc ggggcgggcc aatcggcgct gccccagcag ggctgcggct gcaggcaggc      600

agagcctcct agcccgtcgg tgtctgcgcc catcgatccc tttgtctatc cccgaccatg      660

gcgaagctga ttgcgctcac cctcttgggg atgggactgg cactcttcag gaaccaccag      720

tcttcttacc agtaagttgg gttgtggtga gggctgcagc cttcgtcctc ctcactccct      780

gccagctcca cgagccccca gaaagttggg tccaggctgt taacagaaca tttacaagca      840

ggtgctagat gcacactctg cgggggtttc ataaatgttt gtccagccgt catgtgtcac      900

ttgaaaacaa actcttgctc atggcctgag acatgggata aggaggcaat tgccaggggt      960

gtgagtgccc aggttgtcag catacacgaa ttaatttttc atgaagattt gtgtgccctg     1020

gctacagatt cacttctcaa cctggaaaga aacaaactaa cctggctggg ggttctcctg     1080

atattttgtg tattagagaa aggagcccct gtcgcttctg cgccttgact gcctggccat     1140

ggcaaacctt ccaggcttga agattctcaa attgaggcta ctgagggcca cagcaaaact     1200

gcgtgtggac ccgagcaggt ggagctaacg tgtgctgtga tggttcgctt cagtgggggc     1260

aggcggggaa gagggaaccc tggagccagc atctgatgtc ctggggttta gctctgcccc     1320

atgagtatgc gatttgggca aatcacttta catctctaac cttagctgct tcagtaaact     1380

ggaaatagta atacacactg cctgcgacag agtagctatt caataaatgt tagttccctg     1440

cttcccttta aagtatttaa taaagggtta agtgctatac aaggggggtg gggatatttt     1500

aagaatgtat caaaagtttc ataactttta acaggagttc aaagtctaca gatcatccta     1560

gtctctaagg cttagtcaac aatgccttat ttactttaaa gtaaaaccta ataaaaatta     1620

aatataaaaa aattatatga gcttatggac taattagaag cttacattca gaatgggttt     1680

ttactattta ttgtggatgt ttttctaatt tttttaagtt acagagtgca gaaaaaaagt     1740

aagaagcagt tggtattctt ggcttttaaa tcatgtaaaa attacagttt gtgagttttt     1800

attaatcaca gtgctggtgg ctgccaaagg agattatagg tatagataaa aatatataga     1860

taaaggatgg gttgctgagc ctcctggagt gacccagaca gaggaaggaa gggaaatttt     1920

acccactgtt ggaaacccct aaaacctagc tactcaactg ggtctgggga ccagatgcct     1980

gagcatcacc taggggctcc ctgtacaggc agaatctcaa gccctacccc acactattga     2040

atcagaacca gcgtcatgga acaaactccc tgggggatta gagatcatga atctgcccca     2100

gggagagaag gcaagagatg atatcatgag gcctgcatca ggagcaagcc aaatccccag     2160

gatagatgca tccttttttc ttcagacttg gagtgtatgt gtgtgcggct cacaggaagc     2220

tatatatgcc tgggctggag ggaacttaag gaagcacaca agggatgcct caagagattt     2280

ctgagtttcc caggtgggag cagtacagag aaaagaactg agagagttcc cctagaccac     2340

gagtctccca cccacgagtc tcccaccttt gtagtcggct gtatgtgccg cacaagtcca     2400

gggaatgcct tggatgatgg tagaaacagc tcccctcccc taccccaact tgggctatgg     2460

aatgttgcag catctgtatg gcaacttcct tgtccctaca ttgctaattg caatacgtga     2520

gtccactgag tttcccttct cagaaggaaa ccacaaagct aacgttgggc ctctcgatgc     2580

atttctgcca ttccatgctt actgtaggca acacacagtt gtgggaagag agtagttgtg     2640

gattcctgat gacctgggtt agatatcatt tctgcaactt tcaagttatt ttaccacttt     2700

attccagaaa agttccagcc agtttctcca cccgaaaatt aggggataat aatacatatt     2760

acagcatata tatatatata tacacacaca cacacacaca catacatata tttatattta     2820

tataaaacat ataaataaaa ctaagtatat atatatatat aaaaatcagg catatagcag     2880

atgtcctgta aacgttagct tttatagctg tcatatgtga tctcaaaaat atagagtgat     2940

acttgaatat gtattataat catacttcat tgaaagtctg agataaggac aaataatcct     3000

ccaaccctcc agtctcccct atgaatgcaa ccaacaccat cttctcagtc tgatgtactt     3060

gcctagtatc tccacaaaac acttcagtgg acatctgcag agtaccttct ctttgcaaac     3120

gttgtgtttc tgctggaggt tataggaatg aataggttgc agtattcact caccaatttt     3180

aaagtctact gggagcaaaa gaacaaaaac tgacagctgt gaaactgaca actatgacaa     3240

ctatggtaag aaagttgaca gatgtatatg tgaaggttcc tgagggtaaa ctaaggagtt     3300

attaatccca atgcagaaga ctggagaagc tacaaagcat catgagtagg ggtctttcca     3360

gtgggtaatg ggctaaagag cattctaggt gaagggaaaa gtgtgagcaa ataaaaagag     3420

gtatgaaaga aatacaggga agagtcctta gtatcatgac acttgatttc aaatcccaac     3480

tctaccctct taaataagca accacatgca atttactcag cctctcagtg cctccatttc     3540

cttacctaca aaacagggta aatattcatc tttttctcaa aggtggctaa aaagattaaa     3600

tgaggaagta tgtgtgagag cccttattgg agcttggcac atagtaggcc atgaaaagca     3660

atttgaatga atgaggcgtg tgtagtagca gaaaatagac tgattagagt gaatttggcc     3720

ccaagaagag tttgagaatc gatacggatt tcttaatgcc taggcaaaga tctctgcttt     3780

tttctgcgag cagccagcat gtattttcac cgaatacttc tgccttggtt tggatgttcg     3840

tcctctccaa acctcgtatt tgatctctaa tgttggaggt ggggcccaat gggaggtgtt     3900

tgggtcatga agatggatcc ctcatgaata gattaatgac ctccttggga gtgagtgaat     3960

tctcactcta ttcatttcga gagagctggt tgattgaaaa gagcctggta cctctcccct     4020

ctcttacatt ctctctcatc ccatgatctc tgtgagtact ggcttctctt catcttctgc     4080

aatgagtgga agcagccaga gcccctcacc agatgcagat acccaatcct gaactttcta     4140

accatccaga atcataagcc aaataaacct tttttcttta tcagttgctt agcctcagat     4200

gttcctttag agtgacacaa agcagactca gacaagttca cagcaaaggc tgtatggttt     4260

ctgcgcagag ttcagagtct agtgaatcag agatatatct cagacattga cccttatctc     4320

ttaggcccag aacatttgga cttaagcctt tgacaagata tttcctaata aattgaaaat     4380

gaggtagaaa aaatatgagt tggatgataa taacacaggt gggtcaattt tcaggtgcat     4440

cttccagctt ttaagcagtg ttctctgtag attttgcctg gtcagagagc taaatgtgag     4500

ctttgtgttc atacttgaat tccaatccct gctcagccac tttataactc tgtggcctta     4560

gaaagccact taatcttggt caactataac ttagggaaaa taacacctca cggaggtgtt     4620

tgaggattaa acgcgggcat atacggtacc tgaactatag tagtaatgat tatcctgttg     4680

agatatgaca tgtttgggcc acaaattgga acccaaatca acaagtgctg acttaatgcc     4740

cccttgccca ccctgggctc cctttaactg tgattattct atgttttcca ggctagagat     4800

catcttctat gagagagaag cctgaattag aataggagct gaccagttct gcctttctcc     4860

atcttttgtg aacccatatg tttagtgacc cttgtgagtc aggcagcatg agtattcttc     4920

ccattggttt tgagtctaag aaaagtgaat ttgactatcc ttggtgtttt tcacaagtct     4980

tggcccattc agtgatttta tgtccttgaa tctctccttc catgccagtc tttgtgttgt     5040

cctcggttat gaccatcacc cttaacatct tgtacctgcc ctttggttcc ttgagggcat     5100

gctacaaata ttcactacac tttccctaga ccagagtttt ttcaaatggt gggtaacaaa     5160

gtcaatttag taaataatta ccaacattta aaaataaata aaacagaatt gaacagaaaa     5220

gttatgaatg tatgacacag attaggatga gtattgtttt gtgaagcttg attcagatgt     5280

gtatgtgtat gtgtgtgcat gtgctgggtg ttcgcaccat ataaaatact tttcctactg     5340

tgagtctctg tctgaaaagt ttgtaagcca ctgctttatc acttcccctt ttatttcctt     5400

attgtcaata tttgcaatta taatgtcaga ttttcatttt gaaaatacct ttccctttct     5460

taggttatgg gacagattcc aactttcctt tgaagcctgc tttctaagtt cacatctatc     5520

aatcaggaaa ccacagtctc ctcacagtcc aagccttcat catctattca ttcatctctg     5580

tatttctagt acctagactg gtggctcttt actctggtta tacgttggga caaactgtgg     5640

cacttttaca aagcagatta ttaagaggca ctccttgcct cttacgtcag atttttttag     5700

acagcgaaaa tgatagccag tggcctgatg gtaggaatgt actcattttt ttctgaatga     5760

ataaatgaaa gatcaatcac ccccaaattc ctatcatttt gtaccacgtc ggtaagaatt     5820

ttatctagcg tgtctgttcc gcctgtagcc catccgcctc ctgtgagttc aagtcatcag     5880

gaggacaagt aaatttctta gcctatctga agccaaataa gatttctagg gatatttgga     5940

taattgtcac tacttgctat gacaatactg tatcactagt tctctaaaaa aaaaaaaaaa     6000

agtttattgt ttaaatctct tggttgtgct aacgtcgtct gtttctttca aatgcagcat     6060

cagtagcttc gctctgctca ggcagccggc tggcacttcc ttctcacatc tgttcatttt     6120

tcctttgtcc tttactcaga cattttctat ggtgtttatg cactcatatc taataagtcg     6180

ctcctgtgta tgtgtgtgag tgcacctgtg tgtgtgaaat gcctttttac atgcaggcct     6240

tgtgtatgat tttctgaagt tacaaatcct ttcaacgtac ctgtattttt caagcactac     6300

atcacaaagc agatgcccag tccaggctgc ggagtcagat tgggcagatg agtaggaggc     6360

tgcccatctg tcagcaactc taaaacatca atggaataaa ctggaaccat gttgccattt     6420

acccggactt tccacctagg agtccttaca cactgatgaa attgctcctg ttcctgccaa     6480

agtacacaga gccctagaga ggatattatg tatctcttat gtgtacctat ccacctctgc     6540

taaataaaaa ctaaatattg tacccagagt tccccacttg tcttgccctg gccttgcctg     6600

gaaaaattgc aggaaaaact ctggagttga aactcaggca aagtacagtg aaggagaact     6660

tttgtggact gcctaccttt gcaacttatt ataatttctg aatagttttg tgtgtgtttt     6720

atttctttct cccccacaga acacgactta atgctctccg agaggtacaa cccgtagaac     6780

ttcctaactg taatttagtt aaaggaatcg gtatgtatgt gagaggaaga agggtctcat     6840

ttgaacttcc ggtatttttt tgctctttgt gtgattaatg tgcctgttca attctgtcca     6900

aaaataaaat tttgaatcag gagagtcagt ggtagttaat gataaatacc atgttgtttg     6960

acttttgact tcaccaacat actgccaagg tgttgggagt tttggttgtt tgtttttgtt     7020

tgatcaatag agcaaaaaaa aaaaaaagaa aaaaagaaaa aagaaaaata gaataatgtt     7080

tgattccatg gcaatctaac ctgaggagat ggcagaagag gggagggaga gccagataaa     7140

gcattgaata aaggtaactt ttttttagaa aggctctgac aggactttgc aattaccaca     7200

aggcttctcc ttatgcatct ctcttttgat attggacagg aaaatttttt ccagaagctc     7260

tcagcagatt tccccttaga tcttatttgt cagagctgga ggacaggctg gtgccctagt     7320

tgcaaaggat gctgggaaag taattatcaa gcctccaatg tgggaggcag gccctgtcag     7380

caaagataaa acggtaggag aatagcagct gggaggcaac caacaaggag agtccccggg     7440

ctcaactctc cagctggttc caaccaacca gctttgttat ttgaagacaa ttggtttgag     7500

atcatgcttt tgtgtgcttt gggtgtttct ttttctttct tttttttttt tttttttttg     7560

ttcttttaga attattcatc tcagttgatt aaggctcagg aggctagatc agatgactta     7620

gtaccactaa atttcactag atatcttatg gtgcgattgt tttctagaaa aatatgatat     7680

tgatatcaaa tatcactggg tttttgaaaa gcaaactttc cactaagtgt agaaatacct     7740

atcaaatagt tcatttttct ctagataaat tgaaatgtta aaaatttaca tgtacttaaa     7800

gtataactaa cttgaagaca gtaatattta accgatgttt ataattagta gtaaaaattc     7860

atattcttga tcacctaaaa tgtatcccca ttttaactca actatttgga atttgcttat     7920

atcttcaata tggctttcca agggtttaat tgatttggaa gtattaagta tcaacatata     7980

tttgtaattt accttgtatc tttagaaaac aagttctttt caaataatca tggcttttgt     8040

acgttttgtg aatttccatg aactttaaga ggattcagtc tttgaggaaa aagctctagt     8100

ccatcaattt aaaacaaata tactaagtgt aaattttaat taaacttgtt aatgaattaa     8160

tatattttta atttccatat aatcgcattc atcaatttga ataaatgaaa gaatgaatta     8220

ttctgaacct attaaagaag agtgatgtat agccccagtt tcaagtgagg tgtgataaag     8280

aaatggatcc acatcctgca ataatatgaa acaacctgta ctttctgttc tcttttctgg     8340

cagaaactgg ctctgaagac ttggagatac tgcctaatgg actggctttc attagctctg     8400

tgagtgtttt ctttcacttt tctgtgttct agaacgtttt ctaggactgg cagtttaagt     8460

ctttcactta ggctttctgt atacccatgc ccactttcaa ataaaatgaa cagtcatggt     8520

ttaaaagaca aattgtgtat gcatttacac ttgtgctata attatgatca tgcgtgttct     8580

atgcatattt gtgttcttcg gtctacattg aaccatatta cgttagcttc tattgcagca     8640

atttttttgt gagttcagtg tattcaagaa ttgttttcct ctcaattgtc tattccctaa     8700

gcacttaaaa ttgccatatt caaatatttg ctaaattaaa tatacattta atgtatacta     8760

cttcacaggt catttcaact ttcacatttt taaacaaatt tcagaataag ccctttaatt     8820

taaaattgtt gataggtccc aattcccaat tcccaagctt tgaagacaga atccaccata     8880

tttgctgaaa ctgtcctgca tatagatcgc tatggtagct gatatagtgc aaaacaaaag     8940

aagtccacca tctggcctag ggatcataac ataacagagt tgataggaaa cgacagacaa     9000

tcatccagcc atttaaaaac ctttgctacc ccttgtaatt tacttagtcc agttttctct     9060

tacaaagatg atagactagt catcctgcaa agcaatgtct tgcaaacttt cttgagcaac     9120

ataaggtgta tttcaagcaa aatcttatat gggaacacaa tatataaaac aacagcttta     9180

ttgttttgat tgaaggctaa gaaaggagta gttcctctgg cccaccaaaa ctctgtcttt     9240

gagatgcttc caaggaccta ccagggaaca gtttaaaagc cataagcaat attctctctg     9300

tattccttgc ttatatcatt gaagactatt attaattgcc tttttggtct gctcttccat     9360

ttttgatctt tctcatgggc tggaagctgt agtgtcgtgc acatatgact ttgctgcagg     9420

ggatgaaagg gtttgtgtgg ggtggcctag tggagcatgt ggcttccaga agacttctcc     9480

tggggaccca ttacagaagc taactaagag gcttcctatg tggccatctg gctagccctg     9540

tggtttggag cagtcaacat gaacccatgg gccatgcagc gcctctatta gcatttgaag     9600

tactggtatt gtgcttgatt tttctcctcc atggtttata agggattaaa gtatcctgga     9660

ataaagagct tcaaccccaa cagtcctgga aaaatacttc tgatggacct gaatgaagaa     9720

gatccaacag tgttggaatt ggggatcact ggaagtaaat ttgatgtatc ttcatttaac     9780

cctcatggga ttagcacatt cacagatgaa ggtaacaata tttactattt attaaaacca     9840

aaaccaaact taaaacaaaa acagaaaaac atgccaataa atgaattatt ttttctcatt     9900

caaacaaagc atagtcatga ataatgttct tactctgggt tttaaactta ccctctatgt     9960

taattgaact ttatagtaaa accacttaaa tacttgagaa tgctaaaata tttaagattt    10020

gtaaagcatc taattttgta aaatactaac attcacatta tccctataat taccataata    10080

ataatatcca gccctgatca ttatagcttt tccattttaa acgattttca agactcgggc    10140

atttacagga acagattttt ctaacccaag gcatctgtaa gctataggtc cagtgacaga    10200

aagtcaccat ggtcagcttt ctgccggtcc cattatcttc aatgcctcct gtccgctggt    10260

tcctctgttc tgtgttcaaa atgctcctct gcatgttggt ccctttcaac ataacttggt    10320

gtcatccttt atgtctttac tccctttctc cctttccatt tgctgtcact tccttgtctc    10380

tgtattaatt ttcagcccca gttgcacaat ggtagcacct gaagagttta aaaagactcg    10440

atgcccagcc cccagcttga cagattccaa ttccgttagt ctgagggagg cctggatcac    10500

agtagttgtt aaaagttttt cagttgataa aaatgtcagg ctagggttaa gaaccacgtt    10560

tatacccatt acctccattt catcatcaga cgatccctca ttcagttcct cttctggact    10620

ttccccactg tgggtggcta aaattgctac cttgagaatc atcagtgatg ttcctactaa    10680

caaatctcct ctcttccctt cctccctctc cttccttccc tcttcccttc cttccttcct    10740

tcacctcctt ttgttttttg ttttgttttg tttttgagat ggagtcttgc tctctcccag    10800

gctggagtgc agtggcgcaa tcttggctca ctgaaaactt cacctcccgg gttcaagcaa    10860

ttctcctgcc tcagcctcct gagtagcggg gaccacaggt gcatgccgcc atgcctggct    10920

gatttttcgt attttagtag agacgggggt ttcaccatgt tgcccaggct ggtctcgaac    10980

tcctgagctc aggcaatcct cccatctcgg cctcccaaag tgctgggatt acagttgtga    11040

gccaccgcgc ccagcctact tcacctgctt ttatgctgtt taccattttc tcattcacaa    11100

aacttgctct tccctgatac tgcagtgcac ctagctgttc cagttctcat cctactacag    11160

gttttctccc caattcattg ttttgtcact cattgctact tccctgagca ctaccccaga    11220

ggtttgatct tttacttcct ctatattttc tctattttag aactttcaaa ccagtgtcac    11280

actgcctgct ttctaggagg acatccccaa ataggggtat tattattctt cttcttttca    11340

ttagcccttc acttttaatg ccgcaggtgc ttactggaca cttctatttg gattcctttc    11400

ctatagacac tttaaactca aaatgttgaa agtgattttc catcctttta tctttccttc    11460

tcttccccat gtgagacaca cacacacaca cacacacaca cacacacaca cacatataca    11520

tatatatccc tttcaatgga ctttccactc atccacccat tcatcaccat tatgttttat    11580

tttaaaaata tttttaagta caaagaaata tagtgtttga tgtgtggata ctttttaaaa    11640

taaaaatgag gtaatattac acaacccctt ctataaattt cttctgcatt aaacactaca    11700

tcatggactc ctttatatat agcacatttg cagttgcttt gccaaggcag ttcgggattc    11760

agttgtgtgg gagcactgta atatagctca tctgctaaca aatatttagg ttgttcccac    11820

ctttatgctc attgcaaaca atgccaaaat aaactttctc gcacatgtat tttctgagac    11880

tatatcctta ggatacattt ctagaagtag aatccactgc acaaaatgtg aattcaggtt    11940

ttaatcctca cttgaatttg atttccaaca ccctccttcc tcagctgtat tcagggcctt    12000

tggattcttc ctgtcaaatg cctctcatga cctttcctgc cttttattgc cagtggcatc    12060

ctcttggtcc agtcctttct ctccacattg ctggattact gctgtagcct cagctcatgt    12120

tactccttgg ttcaaatacc ccagtgagca aagcttggat cttcatctta agccctaaca    12180

agactgattc tggctccctg tggtttcagc cctctcactc tcccactctc tcttgccttc    12240

actctgctcc cagcacaacc tcacaattaa gtgaatatgt ccaggaagtt ctgccccggg    12300

gcctttgcac actcccagca caacctcact attaagtgaa tatgtcccgg aagttctgcc    12360

ccggggcctt tgcacactcc cagcacaacc tcactattaa gtgaatatgt ccaggaagtt    12420

ctgccccagg gcctttgcac actttctccc ctcaacctgg aatgctcttt ccctagatat    12480

ccacattatt cgttctctta tttcacttag gtttttgctc taacatcccc tcatcagaga    12540

gaacatgcct gactcccatg aagataatac ttcgttactc tctattcttt tatcctgttg    12600

tatttttcct ttgtagcatt taacgccaac taaaataaat taaacacttg tttgctgaat    12660

ggggtaatga aaatcatttt agcagctttc tctgttcaaa tcttctcaat tcaacctgcc    12720

aaattttgca tcttaacatg gtgaaacccc atctctacta aaaacacaaa aattagccag    12780

gcatggtggt gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatcgctt    12840

gaacctggga ggcggaggtt gcagtgagcc gagatggcgc cattgcactc cagcctgggc    12900

aacaggagtg aaactccgtc tcaaaaacaa aacaaaacaa aacaaaaacg ccaatttgat    12960

catgtcagag gtttcaaaag acctactctt tcttaaggca aagaccataa tctaactttt    13020

acttgccagc tctgatcaca cattcttgac cgcttagact ggtcaccttt gtgttcttaa    13080

agtcccactt atccaaggaa gctgcttctg tttgtttgct actatttctc agatgttctt    13140

ctatggaatg tatcatctca cactgtgtaa attacacctg atcacacctt ctcatattgg    13200

gagttcccat ggtttttatc cctttcatcg caactgtgca tttcgtggag accatttgaa    13260

ctggaaaact taaaggattc tttggagttt tagtgtcagt gatactcatt cttgagaatt    13320

tttttttctc ctgtggagtt ttgagttttc agagactgtc actggttctt ccttgagcca    13380

cttttgtttg gaacaggagc aatcaccaat gcttctctct acaaagagat gaaaatattc    13440

catctgcctg acatcctaac tactagctgg aggtgggttg aaattggttt ttggagagag    13500

ggctgacagt gagagcttag ttaatgtttc atttttgttt ttaatctcct ctcagataat    13560

gccatgtacc tcctggtggt gaaccatcca gatgccaagt ccacagtgga gttgtttaaa    13620

tttcaagaag aagaaaaatc gcttttgcat ctaaaaacca tcagacataa acttctgcct    13680

aagtactgag atatatcaca tttctatttt cctttagctg tagcggatag ttaatccact    13740

tttagttttt ccttttggcc agagtaggta tggctgttca actctcattt ctaatgatca    13800

caaactcctc cacatgctct tctgaagaac cttctgagga ctcaagcccc tcagagacgg    13860

cccattcttt tcctctcttg tttctcgagc tgattggatg ctggctcctg gcctcaggat    13920

ctccattcaa gttattacca ggaaaaaaat cctcttcttc agaaccagac ttagtatttc    13980

aaacccaaac cggcttcata gataaatttg acatcatgag cttatttatt tatattaaaa    14040

agtagactct tagatgtttc catgaattag aaacacagac ccaagaggag accctgaatc    14100

aagtgcatct aagacctcct tatactgcct ccgctgctgt ttgattgcac aaaatttatg    14160

caatagcaga tctgtggtaa cactcaattc cccctaggca ccttgttcat gtaacatatg    14220

gtgaaataaa acactcaaga atctccaatc tcagtcaact tcctcacatg ccctgtgaag    14280

atttggcttg taaggccagt gatggattta ggagaacaat ccgactctat cttctgaaac    14340

atttacctcc aactgattac gattttctag aatcccaacc tatttttata taatttatgt    14400

acagcatttg actacctcca tatctgtaaa tctagatttg tactctttgc aggtacctag    14460

ctaagggcct ggtatgtagt gtgcactctg tgttaccagg accccttcct cttctttctt    14520

atctggtggt ttgaggatga ggaaaatgag attggagaga aattgagtta ctggatgaag    14580

gccaatcaac tcactagtgg ccaagtagga accccagctc aggtcatctt ctgccccatc    14640

aagatgaata aaagttcaga gaacagcttt tggtggaaga gtttattcgt gcatttattt    14700

aacaaatata ttttggagag agaataaggt cactgagtgg agaatgtgag gaacaccaag    14760

atttaaagta gagaacagta tgtagaatgg agaagctggg caaatgataa cactaataaa    14820

tgagctttct ctgtaagtca ggtgctacac taactaattc aaacagatta ttttattgat    14880

gttttacaaa taccttctga attaggtgtt attattatat ccattttgga tttttaaaaa    14940

gttgaggcct ggactaattg ttaagtttcc ccagatgaca tcatcagtaa atggtgcagc    15000

tgtgattcta atcctggtaa catgagttca gagctggtgc tttaaacctc tacaaaatag    15060

tgaaaaaaat tatgtgtttt aacatttaat cttggaaatc tcagattggt ctacgttacc    15120

ggattggagt atttttttct tgagccagtt gcaaaaatat tggtcttagg cagcattgga    15180

gactgaaaat aaccacggtg ccgtaattaa ctagagttct gctctctcaa tccaaggatt    15240

agctgtgtgt attttcttct ttgtatttta tggtttttta taacattaat attccaataa    15300

ctaaatctat tataatttaa acttgttatt attcatatat cacaactgtt attattggtc    15360

atttactgta tgccaggcat ggtgtgaagg cctttgcatt cattatttca ttgtattctt    15420

actctagcct ttcaaggtat acagagaaaa cagaggttca gaatagtggc tcaaaattta    15480

gtgacaatgc tgtggcccca cattataagg atagcaagca gtgtcaggat gcaaatgaag    15540

tccatcagat ttcaaagcta ttactctatt accctttaaa aatttgttat ttatttactt    15600

attttactac acctgggggt agtaaatttt cagcaataaa aagctattgc tctaaaccat    15660

tccactctgc ccctttctgt gaaaaacaga caaatgatag tccagcatac taatttaaga    15720

aatttacttt taaaaaagag agagtaaaat cagattgtag atttatgtct ggagcccatc    15780

cagactaatc ctaaattccg agaccttttt ttttttttca tgttgtaata gtggctagca    15840

ttgattgagg gtttattgaa tgtcatgctc cctgcaaagc acacaacagg cattgtctca    15900

ttgtaattcc cactgcaact ccacaaatta agatcctgac ccttagtttt ctactaatga    15960

gctgtatgat tttgagaata tcatttaacc tctctttaca gatgagaaaa ctgaggctct    16020

gcatgcctgt ctaacttgcc tgagagctca gagctgcgtc agagctgatg cgctggccat    16080

gacgcctctg caatagagca gagataattt tctcccagat catgccctgg ggaacttcca    16140

tcacctcaat cagcaaagaa tgactcactt atgtgttccc tattgtatcc attaaagcag    16200

aaaaatagac tcatatatct tacattttca gtaacagaga atcctaatca gaaaggaaaa    16260

aaaaaaagcc atagcattct atttctgagc attcttgttc atggacattt cattcagttt    16320

agaatcacga aatcttaagg ctggaagatc aaccagtcta tcatcctgct ttcacagata    16380

agaaaactga ggtcctgaca tgtgaaaaga ttgatttttc ttagatcaca cagctaatag    16440

tagcagagct taaactaaaa tgcaagtatc caggctgctg gttcagcatt ttttcaattt    16500

cttatgggag ttagttctat gtgagcccag atatgtgagc acatttttgc cctgacaatg    16560

atttctggct taatttaatt tctactgaat ttagtgtatt tacacacaga cacacacaga    16620

tacacacaca cacacacaca cacacacaca cacacacgac gtaacactat tttaagatac    16680

atataatagg atttttatgt tacagtgcta taatcacctc ctcagatttc ttagaccaat    16740

gattgtctaa ggattgtatc ggcaggacta atttcatatt aattgtgttc cattatagct    16800

agcacgaagg ctccatccca catcttgatt ttaggaatag acagtgagga atgccagtta    16860

ataatcctgt aatgttcaat accttcacct tatatattat gtgtgtatgt tttaattgca    16920

gtttgaatga tattgttgct gtgggacctg agcactttta tggcacaaat gatcactatt    16980

ttcttgaccc ctacttacaa tcctgggaga tgtatttggg tttagcgtgg tcgtatgttg    17040

tctactatag tccaagtgaa gttcgagtgg tggcagaagg atttgatttt gctaatggaa    17100

tcaacatttc acccgatggc aagtatgtga actctctgaa atgtagtgga tttactcaga    17160

ttctcaggag atatcttgga atatattctt tttttaagta atatgataca ttttaacatg    17220

ttaccctagt gagataaaat taggaaaaat gtaaaatgtc ttaatttttc agggggtgaa    17280

atttatcaaa tcaaaaattt cattgtgaag gcatactggt tttatttcct ttttggaaag    17340

aaagtacatt ttaagagggg gaactgtgat gaagatttga tatgtctgaa tagctttgtt    17400

ttgagtaaag atgtgagtgt ataatgagtt gaatagtatg caggtataga tacgtcagta    17460

gtgcaggttt atgacaagat gaggaatttg taccaaaatg taaatcaagg caatacttcc    17520

ttcatcaaga aagtattact gtgaaaaaca agtcagttta actaagcagt gtgcttagtg    17580

atgtatttga tttataatgt tatctcatgg tgagctataa caaacaattt gcaaaccaac    17640

attggtctgg agactgcatt ttgggtagca ttggtatata catgaaatat ctatatccat    17700

ccacatatat gccctttctc atcttgtgtc atcatcaagg attttagagt ccgtaacata    17760

tgcttagaga aagcaacagg ggccaggtgt ggtggttcat gcctgtaatc ctagcacttc    17820

gggaggccaa ggtgggtgga tcacctgagg tcatagacca gcctggccat catggcgaaa    17880

ccccatctct actaaaaata caaaaattag ccaggcgtgg tggcgcactc ctgtaatccc    17940

agctaccagg gaggccaggc aggagaattg cttgaacctg ggaggtggag gttgcagtga    18000

gctgagattg caccactgca ctccagcgtg ggtgacagag caagactctg ttttttttta    18060

aaaaaaaaaa aaagaaagaa agaaagaaaa gaaaaagcaa gcaagcaagc aagtgagagc    18120

aacagggaca gggacagctt ttaattattc atatcataga ccagttttca aaaaatagaa    18180

gataattgag cagtaatttc ttttttttgt tggggggatg cacagtgctt agactaaccc    18240

cagatctttg tggggtatga ctaaagccac agggtcagga ccacactcag ggcagaagag    18300

gaggaagact tctcttgatc caagccaagc agcttttctt ctctcatatt ttctctggat    18360

taaaacaagg ggctgttgtc caagggcttt cctgcaactt tcccgagaga gaactcacta    18420

gcccctgaaa tgcagaacct gggccttgac actaaattgt caaaccaaaa gagaaacgct    18480

gtaatgcatt ttactcccag atactaaaag ttagtgttag ggctaagttc ctcccatact    18540

gataaggaca actatgtccc ctccttcaga aacaactttt cagagattaa acccctctgt    18600

cactgtaaac tcactgagtt ctttcagaat ttggtgtgtt tgaggtgggt tccattttcc    18660

attccttaag caaagttctt ccctatgaat aggtattaca acttcatctt aatctctcaa    18720

gttgtgttac ttctagtact ttgatgtagc tctttcttct ttgaaggtat gtctatatag    18780

ctgagttgct ggctcataag attcatgtgt atgaaaagca tgctaattgg actttaactc    18840

cattgaaggt aagacgtatt aacactgtaa gtctgcagag tgataattag attctaattg    18900

atttgtgaaa ttaaatgtga agaaaaaagg actgcttaat tggggtgggt gagaaccaat    18960

ttttcactcc tttattaaga gtcattagct tggttatgtg tttgttgttc atttttactc    19020

aactgcagag tggcaaacag caaaccccac ctcttacccg tgaaccttgc attctttctg    19080

ctctagcaaa ttttaagctt ggcattgtgt tcccagatcc tccttccatc cctcccttcc    19140

tgcctttctt ctgatctccc tctcctccac cttccttccc tctcctccct tttctttctc    19200

ttttttcctc tatgttgatg gaacagccaa gaaatagcct caaattgtac tttatgcagg    19260

gctgctctcc acaatgttta tgaagtccac gtgctcacga tggctgctag gtgacctggc    19320

tgcccctcac ctctctgcct ttacctccaa ccattgtgtc cctgccccac gtctcctgcc    19380

actgtctcag aacggggcac cattccctct gctaggagga gaaaccttcc tccagatctc    19440

catgaccccc tccttcatct cctttcattt ttactaaaac gtcacctcga tcttcaaaac    19500

ctggaactgc tccctcccgc tacgtatttt ccctcgcctt tcctgcttta tttttccatt    19560

cagcacgtat tgctaacata ctatatattt tattcatacc ctttattacc tgattcccca    19620

actagggtgt aagctccaca aggacaggct gtttttctat ttgcttctgg tacaattcac    19680

attgactagt tggcacttaa caaatacttg ttaaattact gcggtggggc tgggcatgct    19740

tcagggattc acctgctgcc cccaccaatt ctggtcatct gaaggttgga gtcaaaatgg    19800

gtgaaaacac aaaggagagg aaaaagagac caagagcaaa ctagagccct aagaaagcag    19860

ccctctacct ccgaaaaaca gcaagacgtt gctttcctgc cataaacgcc cactgcagga    19920

agcactgtca gcgccaattg tatgactgtt cctgtcagca catctgagag actgtcatga    19980

ggggcctcac tcagagaaaa ttaccttaaa gcaacatcaa atgtaacatc gtgtttgaca    20040

ttaaaaatca ctggcagggc tagtttggta ttagctcaag taaaatggaa tttcacacgc    20100

tcatactggc taagggaata aaaaacaagc tgcggtttta acaacaggta tttctgtaaa    20160

acaaaagtta aagaatttta tgagaataga acccaatgta acagacattc accacagaat    20220

gtcaaggctc tgctctcacc agggtgagac tgagggcaag gccagtttca gcaacagacc    20280

aggcctgtct cccatcatga aaaccccaaa aaggttctcc atcaattgtc acattattct    20340

ttcttttgaa agaccgtatt aattaatatc agttaattaa tgcccgagag tgccaagtaa    20400

tttgataaac tagctgaggc tattcttaaa tttgtgatga ggtgtggatg ggtttatgtc    20460

caattggata ttgttcagcc ttaaaaagga atgaagttct tggccgggtg cggtggctca    20520

cacctgtaat cccagcactg tgggaggctg aggtgggtgg atcacgaggt caagagttca    20580

agaccagcct ggccaatatg gtgaaacccc gtctctacta aaggtacaaa aaattagcca    20640

gacatggtgg cacatgccta taatcccagc tacctgggag actgaggcag gagaatcact    20700

tgaacctggg aggcggaggt tgcagtgagc tgagatcaca ccattgtact ccagtctggg    20760

caacaagagc aaaacgccat ctaaaaaaaa aaaaaaaaaa aaaaaggaat gaagttctga    20820

tacctgctac aacatggata agccttgaaa aacatgatgc taaatgacat aagccagcaa    20880

caaaaggata aatattgtac gatttactaa taggaagtac ctagaacagg caaattcatg    20940

gagacagaaa atagaataga atggtgattg ctaggaactt gggggagaga agaataggga    21000

gctattgttt aatgggtaca ggatttctat ttggggctga ttaaaagttc tggagaggga    21060

tggtgatgat ggttgcacaa cattgtgaat atacttaatg ccactgagtt ttacacttaa    21120

aaatggttaa aatgtcaaat ttttatatat tttaccacga tagaaataat tctctcctct    21180

ctccaaaaaa agattccagg acttagtcaa tgaattagtc acacttcaat gaacctcaat    21240

gcgcaaaaac ctggaatatt tgttaacaga gaatactctg tttttcccaa agagaataat    21300

ttattatgtt ttcttgacca aggaatgcga atttttcgag ttgcctttgt gggagtgtga    21360

gatgtgatac gcaggggtct tgcatgagtt agcatggaga ggaattattt atttgcaagg    21420

caaagagttc attgctggac tcagaacagg ctccctgcta gactgtcagc acttccatgg    21480

catgagctgt gtctgctggg tacctggtgc tctccaggtg ttgcgttcct tgcagagctc    21540

atgtaggagc tcagtaattg tgtcttgaat gaatgggacc ccaggtttct gtgtccttct    21600

cccactccca ctctcatctc aggtttcatc tgccgtggaa ttcaccaatt ggctgtactg    21660

cttccaaaga taagagcaaa gccctgaaac aaacattttc ctcattcaaa gacattatgg    21720

tatcagagtg gtgtgctgac actgggatgg acaggggttt agggatggag aaagcaagca    21780

tggagccgcc tgtcttgcct gtctctgggg taagaaagac tgatggctct gcatggtggc    21840

gagactgagg ctctgccatg atgcttgagc cctctaatcc ctccttgggc atgtgaggaa    21900

cagctctcat tttgagtagg aggcacaggg aaacgttggt tttctgcagc tgtctgctta    21960

tgccctggct ttttcaatga gtcatgacca gttatttaca ggttctctgg gcactgaggt    22020

atgctggcct ctgaggtaca tggtagatat tatttctcca actgagaatt agaggtaaac    22080

aaatagatgg gatttctccc cagtagaagg cagccaagat gatgaatggt ggaattaaga    22140

atcattggta ttatttatga tccttgtaca aagcctcgac agcaatctgt gcagtcatca    22200

aatgcttgca acttatattt agagaataaa cagcagaaga acggggagtt gaacaacatc    22260

aggaaactaa agaacaaact tttcctcaac tacaaggcaa aaatgagacc ctgggtgatc    22320

atttcttctc tggctgcaca gcctatgatt agccattaaa gagtccacat ttcattgata    22380

ttcttctgag aaagaatcta catttcctgg ttgttttctg aatgcttata aaaatatcat    22440

taccacatgc cattttagaa ggagatgttt tatgatgcac cgaaaacttc tttttttttt    22500

cagttttagg ttcatgcaca gatgttggta caaatgattt tgtctaactt ttaacagtct    22560

ttcttggctt tctgtatctt caccctaccc aattctgccc tggaaactga caaaatacta    22620

gcatagatga aaggtcagag aaattttgtg agtcttattg aaatggggca gaattgtatc    22680

cttggaagca gcagcgtggt gaccaaggac aagaggcaac ttttctctga tatattttgc    22740

tccatcacaa ttgtgtttta ctttatgtct tgttcttttc ttgtttttaa tcttttaagt    22800

cccttgactt taataccctc gtggataaca tatctgtgga tcctgagaca ggagaccttt    22860

gggttggatg ccatcccaat ggcatgaaaa tcttcttcta tgactcagag aatcctcctg    22920

catcagaggt aagttttaaa aatgaaccag ataagtgact ttattcccag ctactgtttt    22980

ttcagttgac aacataattc tcaattcttg gttttttttt tttttttttt ttttttgtga    23040

cagagtatcg ctctgtcgcc caggctggag tgcagtggcg caatcttggc tcactgcaag    23100

ctccgcctcc cgggttcaca ccattctcct gcctcagcct cccaagtagt tgggaccaca    23160

ggcgcatgcc accatgcctg gctaattttt tgtatttttt ttttttttta gtagagacag    23220

ggtttcatcc tgttggccag gatggtcttg atctgctgac cttgtgatcc acccgcctcg    23280

gcctcccaaa gtgccgggat tacaggcgtg agccaccgtg cccggccaat tctcaattct    23340

atgtgcaaat aaaagggggg acatggatag atgatccaaa tgatcagaaa tgaaggcttt    23400

tggaggtgct ttagtcagag tctaggcaag aaacacatgg cacacttaaa ttggataatt    23460

tgaggggagt ttaatcaacg gactatacac aaaatgtgtg gacacagtgt agggtaatca    23520

acagagttat aatgcagtac cccagggcta gcaagggagg gaggaaatga ataccagaag    23580

ccagaacagg tagacggtgg tgggtggaga gggttgcctg acaggaactt ggcctctggt    23640

taagggatcc tcaaagaaca taatgatgcc atactgctat ggtttaatca ttcattacct    23700

gccttcctat tcaactcccc cttcctgtgt ggcggtatac gcacaggtcc atgcaatgga    23760

ccagtcctgg agcacactgg ccagcctctc tagatcttcc tgcaggtggc aagataaata    23820

gctggaatta ttctggctta gaagatctca tcttccacct tagttacagt actcaaaggt    23880

cccatttttt gtccacggtc tttattcagt gaactatttt gggtacaagt aagaatttgc    23940

aacctacttc aatataggta tttgcacatt tactgagttt tcagtatcta ctaaggatac    24000

ttattactta catcatatat atgatatcat cttgacatat ttgtctactg ctgtgtattg    24060

ttaaagctca gttttaagag tccatttcac ctgcccaaca ggaaaaaaaa aagtgttaaa    24120

gcccgtatct cttgggttaa aaaaaaaaga aacaaatgtg tatttccatt tacattatgg    24180

ctctcttacc ttttatctct aggtttgcag gacaattgtg atcatgttta atggcaaccc    24240

tttgtgcctt ttgctagttt ttagctatta gggttgctga atggtatgtt taatagaatt    24300

gaagaaatgt atgctgtgga gtgttcagtg ctcagaactg agcagaatgt tagattctaa    24360

tttgttcttg cttgttagct catttagtaa ccttgggtca tttgctatag catggacttg    24420

gtttgttgtt ctggagaaaa tacttcattt ctaatgattg atctgcaaag gagtagcaaa    24480

aagtagtaac aattccttat ccaatgcact gcccctagat gagtgattta gttttattaa    24540

caagaagctt agctaagcca aggtgtacca tcaactattt ccctgtaact actacatgtt    24600

aatgctatgg caacttccta agacatctgt ctttggtgcc agctgttttt aagaggtcat    24660

tttgaacgtt cccacagacc cttttatatc cacgcagtgg ccttcaccgt ctgccacatt    24720

tgtgatgtag atatcctttc ttcaagtcat tatatattat cataaaggct taataataga    24780

aagctagagc tgaaggggaa tttagagata atctagtccc acccatttca ttctacagat    24840

gagaaacaaa tgtgagtgga agatccaaga catgacccag gtctcccacc tcagtgtagt    24900

gcttttcata ctaagttgaa tcacacgcta ttgctatttt ttacagtcag aatgatcaga    24960

tattggctat ttcatatggt tggcttaaca tgatactaca ctgttattat tgatacaatc    25020

acatttctcc tcaattaagt gaaggaaact gaacttacaa aatcttatac atttagagac    25080

aggaggttaa gttcagaaca catgagtatg gtacacagat atggtttttt gagggccaca    25140

ttttttttct tgtctgcatt ttaaaaacca ggaattaagt gtaaacatcc agttagttcc    25200

ctggcttacc tgaaaataca tgaaaacgga ccttaattac tgcatggcaa cagtttggct    25260

attgctgagt gtattagtca aggttcccta gagggacaga actaatagga tatatatata    25320

tgtaaagggg gtttattaag tattaactta cctgatcaca agatcccaca gtaggcggtc    25380

tgcaagcctg aggagcaagg agagccagtc tgagtctcaa aactgaagaa tttggagtct    25440

gatgtttgag ggcaggaagc atcagcatgg gagaaagatg taggctggga gggtaggcca    25500

gtctctcctc ttcatgtttt tctgcctgct ttatattcgc tggcagctga ttagattgtg    25560

cccacccaga ttaagggtgg gtctgccttt tgcagcccac tgactcaaat gttaatctcc    25620

tttggcaaca cgctcacaga cacccaggat caatactttg catccttcaa tccaatcaag    25680

ttgactctca gtattaacta tcatactgag taacagcttc ctccctccac atttactgaa    25740

atccccactg ctccctaatg tcccacatcc aggatgcgct gctcatttgc atttcctgcc    25800

tcatccctgt aggtctagat actctccacc tctgctaaag atcacttgag atcagtaccc    25860

acctgttccc aaatgaagaa acaggtgtgt taagtgtaat tttggaacaa aataggattt    25920

atctcattgt ataagattat atggcttctt atggaggatg accctattat gcataaggtt    25980

gttttaagtg acttaacaaa aatattaacc caatgttatt tcttccacag gtgcttcgaa    26040

tccagaacat tctaacagaa gaacctaaag tgacacaggt ttatgcagaa aatggcacag    26100

tgttgcaagg cagtacagtt gcctctgtgt acaaagggaa actgctgatt ggcacagtgt    26160

ttcacaaagc tctttactgt gagctctaac agaccgattt gcacccatgc catagaaact    26220

gaggccatta tttcaaccgc ttgccatatt ccgaggaccc agtgttctta gctgaacaat    26280

gaatgctgac cctaaatgtg gacatcatga agcatcaaag cactgtttaa ctgggagtga    26340

tatgatgtgt agggcttttt tttgagaata cactatcaaa tcagtcttgg aatacttgaa    26400

aacctcattt accataaaaa tccttctcac taaaatggat aaatcagtta tgtcaattgt    26460

cagatattaa ataacagtgt gtgaccccaa aagtacttac cctaaaacat gtgttgcctg    26520

gaagcacatg tgtgtatcgc tgccttgcca tgtcttgttc agaagacaca ggggagcagg    26580

gttagctcac gtgtctttag aactccagta ctcacccagg gactccagtt cacaggccag    26640

aaaacatatg cattatgaag ttcccctcta ctccatgcac atagtaagtc tgactatggc    26700

agtcagactt acttactccc attttccctt cgatatatga ctttttctca gtaaatatta    26760

acctgaatta ttccaactcc ccttgtactc ttgctttttc aattctcctg ttgcaatgac    26820

acataggaaa atcttaaaat tcttgggagt gttgtcacac ctgaaaatta tgagtctcta    26880

tgatcttggc acaaattgta catttgagtg tctttgactt ggttaaagga agtttgttca    26940

cttcgatgac tggatacaga atgaatccca taattgacat gggcgaagct aaaagtgtcc    27000

ccaaagacta cactgttgtt gaggtggtgg tagtgctggt gggtttttgt ttaatattta    27060

aacttcttgt tgtggaggct gaaaagaaaa aaaataatag aaaggtaaac aaacaaataa    27120

atagaaaaga tcaacaaccc ctttggctat ctactgagac atgactagga agaaaacatg    27180

actttatcat tttgttatag aaactgatat ataaaggtta cacattttca tttatttgtt    27240

tttctgattt gaaggtataa ccttcatgat gaattacttc ttcagggtgt taaggcagtg    27300

actttagaaa caaatttttt tcttgttttt gttttgtttt tgagaccgaa tctcactctg    27360

ttgcccaggc tggagtgcag tggtgcgatc ttggctcact gcaacttcta cctccgaggt    27420

tcaagagatt cttgtgcctc agcctcccgg atagctggga ctacaggcac acaccaccat    27480

gcccggctaa tttttgtatt tttagtagag acggggtttc accatgttgg ccagcctggt    27540

ctcgaacacc tgacctcagg tgatccaccc gccttggcct tccaaagtgc tgggattaca    27600

ggtgcgagcc accacaccca gccagaaacg aagtttttct aaggcacttg ttatgatgat    27660

agtctggcat ttccgggaaa atgttttgcc aataaattga gaaccaccaa cagttgttta    27720

agaatcactg acttgaagta ataaacagga acattttgtt tgggtcaaaa aaccacttta    27780

ttcacagcaa gattggagtt actcatgatt ccagtgacat aatatcccgt gccctacatg    27840

ggctcaattt ttctgagatg ctgctcacag cccaggatgc tgggttctct gaaagactgt    27900

cttgaaatta tcaatgagtg tgatgcttag ggaacacccc caacatattt cattatttag    27960

aaagaaagaa tttcctgagt agttaggctc cctaacatct tcaataaaat gaccacattc    28020

tgttctttct tgttcttgat gatagataag caaattc                             28057


