                         SEQUENCE LISTING

<110>  Bayer AG
 
<120>  INHIBITORS OF IL-11 OR IL-11Ra FOR USE IN THE TREATMENT OF 
       ABNORMAL UTERINE BLEEDING

<130>  BHC213029

<160>  197   

<170>  PatentIn version 3.5

<210>  1
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  2
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr 
1               5                   10                  15      


Arg Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu 
            20                  25                  30          


Arg Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly 
        35                  40                  45              


Thr Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu 
    50                  55                  60                  


Met Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His 
                85                  90                  95      


Ala Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly 
            100                 105                 110         


Leu Leu Leu Leu Lys Thr Arg Leu 
        115                 120 


<210>  3
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  4
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp 
385                 390 


<210>  5
<211>  2378
<212>  DNA
<213>  Homo sapiens

<400>  5
actgccgcgg ccctgctgct cagggcacat gcctcccctc cccaggccgc ggcccagctg       60

accctcgggg ctcccccggc agcggacagg gaagggttaa aggcccccgg ctccctgccc      120

cctgccctgg ggaacccctg gccctgtggg gacatgaact gtgtttgccg cctggtcctg      180

gtcgtgctga gcctgtggcc agatacagct gtcgcccctg ggccaccacc tggcccccct      240

cgagtttccc cagaccctcg ggccgagctg gacagcaccg tgctcctgac ccgctctctc      300

ctggcggaca cgcggcagct ggctgcacag ctgagggaca aattcccagc tgacggggac      360

cacaacctgg attccctgcc caccctggcc atgagtgcgg gggcactggg agctctacag      420

ctcccaggtg tgctgacaag gctgcgagcg gacctactgt cctacctgcg gcacgtgcag      480

tggctgcgcc gggcaggtgg ctcttccctg aagaccctgg agcccgagct gggcaccctg      540

caggcccgac tggaccggct gctgcgccgg ctgcagctcc tgatgtcccg cctggccctg      600

ccccagccac ccccggaccc gccggcgccc ccgctggcgc ccccctcctc agcctggggg      660

ggcatcaggg ccgcccacgc catcctgggg gggctgcacc tgacacttga ctgggccgtg      720

aggggactgc tgctgctgaa gactcggctg tgacccgggg cccaaagcca ccaccgtcct      780

tccaaagcca gatcttattt atttatttat ttcagtactg ggggcgaaac agccaggtga      840

tccccccgcc attatctccc cctagttaga gacagtcctt ccgtgaggcc tggggggcat      900

ctgtgcctta tttatactta tttatttcag gagcaggggt gggaggcagg tggactcctg      960

ggtccccgag gaggagggga ctggggtccc ggattcttgg gtctccaaga agtctgtcca     1020

cagacttctg ccctggctct tccccatcta ggcctgggca ggaacatata ttatttattt     1080

aagcaattac ttttcatgtt ggggtgggga cggaggggaa agggaagcct gggtttttgt     1140

acaaaaatgt gagaaacctt tgtgagacag agaacaggga attaaatgtg tcatacatat     1200

ccacttgagg gcgatttgtc tgagagctgg ggctggatgc ttgggtaact ggggcagggc     1260

aggtggaggg gagacctcca ttcaggtgga ggtcccgagt gggcggggca gcgactggga     1320

gatgggtcgg tcacccagac agctctgtgg aggcagggtc tgagccttgc ctggggcccc     1380

gcactgcata gggccttttg tttgtttttt gagatggagt ctcgctctgt tgcctaggct     1440

ggagtgcagt gaggcaatct gaggtcactg caacctccac ctcccgggtt caagcaattc     1500

tcctgcctca gcctcccgat tagctgggat cacaggtgtg caccaccatg cccagctaat     1560

tatttatttc ttttgtattt ttagtagaga cagggtttca ccatgttggc caggctggtt     1620

tcgaactcct gacctcaggt gatcctcctg cctcggcctc ccaaagtgct gggattacag     1680

gtgtgagcca ccacacctga cccataggtc ttcaataaat atttaatgga aggttccaca     1740

agtcaccctg tgatcaacag tacccgtatg ggacaaagct gcaaggtcaa gatggttcat     1800

tatggctgtg ttcaccatag caaactggaa acaatctaga tatccaacag tgagggttaa     1860

gcaacatggt gcatctgtgg atagaacgcc acccagccgc ccggagcagg gactgtcatt     1920

cagggaggct aaggagagag gcttgcttgg gatatagaaa gatatcctga cattggccag     1980

gcatggtggc tcacgcctgt aatcctggca ctttgggagg acgaagcgag tggatcactg     2040

aagtccaaga gttcgagacc ggcctgcgag acatggcaaa accctgtctc aaaaaagaaa     2100

gaatgatgtc ctgacatgaa acagcaggct acaaaaccac tgcatgctgt gatcccaatt     2160

ttgtgttttt ctttctatat atggattaaa acaaaaatcc taaagggaaa tacgccaaaa     2220

tgttgacaat gactgtctcc aggtcaaagg agagaggtgg gattgtgggt gacttttaat     2280

gtgtatgatt gtctgtattt tacagaattt ctgccatgac tgtgtatttt gcatgacaca     2340

ttttaaaaat aataaacact atttttagaa taacagaa                             2378


<210>  6
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  6
actgccgcgg ccctgctgct cagggcacat gcctcccctc cccaggccgc ggcccagctg       60

accctcgggg ctcccccggc agcggacagg gaagggttaa aggcccccgg ctccctgccc      120

cctgccctgg ggaacccctg gccctgtggg gacatgaact agggacaaat tcccagctga      180

cggggaccac aacctggatt ccctgcccac cctggccatg agtgcggggg cactgggagc      240

tctacagctc ccaggtgtgc tgacaaggct gcgagcggac ctactgtcct acctgcggca      300

cgtgcagtgg ctgcgccggg caggtggctc ttccctgaag accctggagc ccgagctggg      360

caccctgcag gcccgactgg accggctgct gcgccggctg cagctcctga tgtcccgcct      420

ggccctgccc cagccacccc cggacccgcc ggcgcccccg ctggcgcccc cctcctcagc      480

ctgggggggc atcagggccg cccacgccat cctggggggg ctgcacctga cacttgactg      540

ggccgtgagg ggactgctgc tgctgaagac tcggctgtga cccggggccc aaagccacca      600

ccgtccttcc aaagccagat cttatttatt tatttatttc agtactgggg gcgaaacagc      660

caggtgatcc ccccgccatt atctccccct agttagagac agtccttccg tgaggcctgg      720

ggggcatctg tgccttattt atacttattt atttcaggag caggggtggg aggcaggtgg      780

actcctgggt ccccgaggag gaggggactg gggtcccgga ttcttgggtc tccaagaagt      840

ctgtccacag acttctgccc tggctcttcc ccatctaggc ctgggcagga acatatatta      900

tttatttaag caattacttt tcatgttggg gtggggacgg aggggaaagg gaagcctggg      960

tttttgtaca aaaatgtgag aaacctttgt gagacagaga acagggaatt aaatgtgtca     1020

tacatatcca cttgagggcg atttgtctga gagctggggc tggatgcttg ggtaactggg     1080

gcagggcagg tggaggggag acctccattc aggtggaggt cccgagtggg cggggcagcg     1140

actgggagat gggtcggtca cccagacagc tctgtggagg cagggtctga gccttgcctg     1200

gggccccgca ctgcataggg ccttttgttt gttttttgag atggagtctc gctctgttgc     1260

ctaggctgga gtgcagtgag gcaatctgag gtcactgcaa cctccacctc ccgggttcaa     1320

gcaattctcc tgcctcagcc tcccgattag ctgggatcac aggtgtgcac caccatgccc     1380

agctaattat ttatttcttt tgtattttta gtagagacag ggtttcacca tgttggccag     1440

gctggtttcg aactcctgac ctcaggtgat cctcctgcct cggcctccca aagtgctggg     1500

attacaggtg tgagccacca cacctgaccc ataggtcttc aataaatatt taatggaagg     1560

ttccacaagt caccctgtga tcaacagtac ccgtatggga caaagctgca aggtcaagat     1620

ggttcattat ggctgtgttc accatagcaa actggaaaca atctagatat ccaacagtga     1680

gggttaagca acatggtgca tctgtggata gaacgccacc cagccgcccg gagcagggac     1740

tgtcattcag ggaggctaag gagagaggct tgcttgggat atagaaagat atcctgacat     1800

tggccaggca tggtggctca cgcctgtaat cctggcactt tgggaggacg aagcgagtgg     1860

atcactgaag tccaagagtt cgagaccggc ctgcgagaca tggcaaaacc ctgtctcaaa     1920

aaagaaagaa tgatgtcctg acatgaaaca gcaggctaca aaaccactgc atgctgtgat     1980

cccaattttg tgtttttctt tctatatatg gattaaaaca aaaatcctaa agggaaatac     2040

gccaaaatgt tgacaatgac tgtctccagg tcaaaggaga gaggtgggat tgtgggtgac     2100

ttttaatgtg tatgattgtc tgtattttac agaatttctg ccatgactgt gtattttgca     2160

tgacacattt taaaaataat aaacactatt tttagaataa cagaaaaa                  2208


<210>  7
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  7
agagggcgag ggcgagggca gagggcgctg gcggcagcgg ccgcggaaga tgagcagcag       60

ctgctcaggg ctgagcaggg tcctggtggc cgtggctaca gccctggtgt ctgcctcctc      120

cccctgcccc caggcctggg gccccccagg ggtccagtat gggcagccag gcaggtccgt      180

gaagctgtgt tgtcctggag tgactgccgg ggacccagtg tcctggtttc gggatgggga      240

gccaaagctg ctccagggac ctgactctgg gctagggcat gaactggtcc tggcccaggc      300

agacagcact gatgagggca cctacatctg ccagaccctg gatggtgcac ttgggggcac      360

agtgaccctg cagctgggct accctccagc ccgccctgtt gtctcctgcc aagcagccga      420

ctatgagaac ttctcttgca cttggagtcc cagccagatc agcggtttac ccacccgcta      480

cctcacctcc tacaggaaga agacagtcct aggagctgat agccagagga ggagtccatc      540

cacagggccc tggccatgcc cacaggatcc cctaggggct gcccgctgtg ttgtccacgg      600

ggctgagttc tggagccagt accggattaa tgtgactgag gtgaacccac tgggtgccag      660

cacacgcctg ctggatgtga gcttgcagag catcttgcgc cctgacccac cccagggcct      720

gcgggtagag tcagtaccag gttacccccg acgcctgcga gccagctgga cataccctgc      780

ctcctggccg tgccagcccc acttcctgct caagttccgt ttgcagtacc gtccggcgca      840

gcatccagcc tggtccacgg tggagccagc tggactggag gaggtgatca cagatgctgt      900

ggctgggctg ccccatgctg tacgagtcag tgcccgggac tttctagatg ctggcacctg      960

gagcacctgg agcccggagg cctggggaac tccgagcact gggaccatac caaaggagat     1020

accagcatgg ggccagctac acacgcagcc agaggtggag cctcaggtgg acagccctgc     1080

tcctccaagg ccctccctcc aaccacaccc tcggctactt gatcacaggg actctgtgga     1140

gcaggtagct gtgctggcgt ctttgggaat cctttctttc ctgggactgg tggctggggc     1200

cctggcactg gggctctggc tgaggctgag acggggtggg aaggatggat ccccaaagcc     1260

tgggttcttg gcctcagtga ttccagtgga caggcgtcca ggagctccaa acctgtagag     1320

gacccaggag ggcttcggca gattccacct ataattctgt cttgctggtg tggatagaaa     1380

ccaggcagga cagtagatcc ctatggttgg atctcagctg gaagttctgt ttggagccca     1440

tttctgtgag accctgtatt tcaaatttgc agctgaaagg tgcttgtacc tctgatttca     1500

ccccagagtt ggagttctgc tcaaggaacg tgtgtaatgt gtacatctgt gtccatgtgt     1560

gaccatgtgt ctgtgaggca gggaacatgt attctctgca tgcatgtatg taggtgcctg     1620

gggagtgtgt gtgggtcctt ggctcttggc ctttcccctt gcaggggttg tgcaggtgtg     1680

aataaagaga ataaggaagt tcttggagat tatactcaga aaaaaaaa                  1728


<210>  8
<211>  432
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ser Ser Ser Cys Ser Gly Leu Thr Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ser Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Pro Val Met Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Ser Ala Gly Thr Pro Val Ser Trp Phe Arg Asp Gly Asp 
    50                  55                  60                  


Ser Arg Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Arg Leu Val 
65                  70                  75                  80  


Leu Ala Gln Val Asp Ser Pro Asp Glu Gly Thr Tyr Val Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Val Ser Gly Gly Met Val Thr Leu Lys Leu Gly Phe Pro 
            100                 105                 110         


Pro Ala Arg Pro Glu Val Ser Cys Gln Ala Val Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Gly Gln Val Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Leu Pro Gly Ala Glu Ser Gln Arg 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Glu 
                165                 170                 175     


Ala Ser Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Glu Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Cys Leu Leu 
        195                 200                 205             


Asp Val Arg Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu His Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Arg Arg Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ile Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Ala Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Pro Leu 
305                 310                 315                 320 


Gln Asp Glu Ile Pro Asp Trp Ser Gln Gly His Gly Gln Gln Leu Glu 
                325                 330                 335     


Ala Val Val Ala Gln Glu Asp Ser Pro Ala Pro Ala Arg Pro Ser Leu 
            340                 345                 350         


Gln Pro Asp Pro Arg Pro Leu Asp His Arg Asp Pro Leu Glu Gln Val 
        355                 360                 365             


Ala Val Leu Ala Ser Leu Gly Ile Phe Ser Cys Leu Gly Leu Ala Val 
    370                 375                 380                 


Gly Ala Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Ser Gly Lys 
385                 390                 395                 400 


Asp Gly Pro Gln Lys Pro Gly Leu Leu Ala Pro Met Ile Pro Val Glu 
                405                 410                 415     


Lys Leu Pro Gly Ile Pro Asn Leu Gln Arg Thr Pro Glu Asn Phe Ser 
            420                 425                 430         


<210>  9
<211>  432
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ser Ser Ser Cys Ser Gly Leu Thr Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ser Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Pro Val Met Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Ser Ala Gly Thr Pro Val Ser Trp Phe Arg Asp Gly Asp 
    50                  55                  60                  


Ser Arg Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Arg Leu Val 
65                  70                  75                  80  


Leu Ala Gln Val Asp Ser Pro Asp Glu Gly Thr Tyr Val Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Val Ser Gly Gly Met Val Thr Leu Lys Leu Gly Phe Pro 
            100                 105                 110         


Pro Ala Arg Pro Glu Val Ser Cys Gln Ala Val Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Gly Gln Val Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Leu Pro Gly Ala Glu Ser Gln Arg 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Glu 
                165                 170                 175     


Ala Ser Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Glu Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Cys Leu Leu 
        195                 200                 205             


Asp Val Arg Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu His Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Arg Arg Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ile Gly Leu Glu Glu Val Ile Thr Asp Thr Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Ala Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Leu Leu 
305                 310                 315                 320 


Gln Asp Glu Ile Pro Asp Trp Ser Gln Gly His Gly Gln Gln Leu Glu 
                325                 330                 335     


Ala Val Val Ala Gln Glu Asp Ser Leu Ala Pro Ala Arg Pro Ser Leu 
            340                 345                 350         


Gln Pro Asp Pro Arg Pro Leu Asp His Arg Asp Pro Leu Glu Gln Val 
        355                 360                 365             


Ala Val Leu Ala Ser Leu Gly Ile Phe Ser Cys Leu Gly Leu Ala Val 
    370                 375                 380                 


Gly Ala Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Ser Gly Lys 
385                 390                 395                 400 


Glu Gly Pro Gln Lys Pro Gly Leu Leu Ala Pro Met Ile Pro Val Glu 
                405                 410                 415     


Lys Leu Pro Gly Ile Pro Asn Leu Gln Arg Thr Pro Glu Asn Phe Ser 
            420                 425                 430         


<210>  10
<211>  1761
<212>  DNA
<213>  Mus musculus

<400>  10
tattggcgct gggaggagcc gcccccactg cctgcgctca gcactggagg gagcagaggc       60

cggggcagag ggtgagggcg gagggcgctg gcggcggctg ccgcagaaga tgagcagcag      120

ctgctcaggg ctgaccaggg tcctggtggc cgtggctaca gccctggtgt cttcctcctc      180

cccctgcccc caagcttggg gtcctccagg ggtccagtat ggacaacctg gcaggcccgt      240

gatgctgtgc tgccccggag tgagtgctgg gactccagtg tcctggtttc gggatggaga      300

ttcaaggctg ctccagggac ctgactctgg gttaggacac agactggtct tggcccaggt      360

ggacagccct gatgaaggca cttatgtctg ccagaccctg gatggtgtat cagggggcat      420

ggtgaccctg aagctgggct ttcccccagc acgtcctgaa gtctcctgcc aagcggtaga      480

ctatgaaaac ttctcctgta cttggagtcc aggccaggtc agcggtttgc ccacccgcta      540

ccttacttcc tacaggaaga agacgctgcc aggagctgag agtcagaggg aaagtccatc      600

caccgggcct tggccgtgtc cacaggaccc tctggaggcc tcccgatgtg tggtccatgg      660

ggcagagttc tggagtgagt accggatcaa tgtgaccgag gtgaacccac tgggtgccag      720

cacgtgccta ctggatgtga gattacagag catcttgcgt cctgatccac cccaaggact      780

gcgggtggaa tccgtacctg gttacccgag acgcctgcat gccagctgga cataccctgc      840

ctcctggcgt cgccaacccc actttctgct caagttccgg ttgcaatacc gaccagcaca      900

gcatccagcc tggtccacgg tggagcccat tggcttggag gaagtgataa cagatgctgt      960

ggctgggctg ccacacgcgg tacgagtcag tgccagggac tttctggatg ctggcacctg     1020

gagcgcctgg agcccagagg cctggggtac tcctagcact ggtcccctgc aggatgagat     1080

acctgattgg agccagggac acggacagca gctagaggca gtagtagctc aggaggacag     1140

cccggctcct gcaaggcctt ccttgcagcc ggacccaagg ccacttgatc acagggaccc     1200

cttggagcaa gtagctgtgt tagcgtctct gggaatcttc tcttgccttg gcctggctgt     1260

tggagctctg gcactggggc tctggctgag gctgagacgg agtgggaagg atggaccgca     1320

aaaacctggg ctcttggcac ccatgatccc ggtggaaaag cttccaggaa ttccaaacct     1380

gcagaggacc ccagagaact tcagctgatt tcatctgtaa cccggtcaga cttgggtggt     1440

taaaaggaca ggcagaaaga ggcggggcag tggatccctg tggatggagg tctcagctga     1500

aagtctgagc tcttttcttt gacacctata ctccaaactt gctgccggct gaaggctgtc     1560

tggacttccg atgtcctgag gtggaagtcc acctgaggaa tgtgtacaga agtctgtgtt     1620

cctgtgatcg tgtgtgtatg tgagacaggg agcaaaagtt ctctgcatgt gtgtacagat     1680

gattggagag tgtgtgcggt cttgggcttg gcccttctgg gaagtgtgaa gagttgaaat     1740

aaaagagacg gaagtttttg g                                               1761


<210>  11
<211>  2680
<212>  DNA
<213>  Mus musculus

<400>  11
gactcagtcc agaccccttc ccccccgcct ggggtcaggg ctggacaggg aggagaagcg       60

agctccttgc aagacgagtt ggggacgaga tagctagtga ccctggcctt ggctgacccg      120

aaagaggcct ggagacatct gtcctcaaag gattgtccac ttccggtgac tccctgctgc      180

tgataatagg gcccatgttt cccagaaggc ccgaggttat cccaagactg cttctctccc      240

ttcacctccc atggcttcat tcctgaagag cctgtgatca cttagggtca gaaatagacg      300

gatgagcagc agctgctcag ggctgaccag ggtcctggtg gccgtggcta cagccctggt      360

gtcttcctcc tccccctgcc cccaagcttg gggtcctcca ggggtccagt atggacaacc      420

tggcaggccc gtgatgctgt gctgccccgg agtgagtgct gggactccag tgtcctggtt      480

tcgggatgga gattcaaggc tgctccaggg acctgactct gggttaggac acagactggt      540

cttggcccag gtggacagcc ctgatgaagg cacttatgtc tgccagaccc tggatggtgt      600

atcagggggc atggtgaccc tgaagctggg ctttccccca gcacgtcctg aagtctcttg      660

ccaagcggta gactatgaaa acttctcctg tacttggagt ccaggccagg tcagcggttt      720

gcccacccgc taccttactt cctacaggaa gaagacgctg ccaggagctg agagtcagag      780

ggaaagtcca tccaccgggc cttggccgtg tccacaggac cctctggagg cctcccgatg      840

tgtggtccat ggggcagagt tctggagtga gtaccggatc aatgtgaccg aggtgaaccc      900

actgggtgcc agcacgtgcc tactggatgt gagattacag agcatcttgc gtcccgatcc      960

accccaagga ctgcgggtgg aatccgtacc tggttaccca agacgcctgc atgccagctg     1020

gacataccct gcctcctggc gtcgccaacc ccactttctg ctcaagttcc ggttgcaata     1080

ccgaccagca cagcatccag cctggtccac ggtggagccc attggcttgg aggaagtgat     1140

aacagatact gtggctgggc tgccccacgc ggtacgagtc agtgccaggg actttctgga     1200

tgctggcacc tggagcgcct ggagcccaga ggcctggggt actcctagca ctggtctcct     1260

gcaggatgag atacctgatt ggagccaggg acatggacag cagctagagg cagtagtagc     1320

tcaggaggac agcctggctc ctgcaaggcc ttccttgcag ccagacccaa ggccacttga     1380

tcacagggat cccttggagc aagtagctgt gttagcatct ctgggaatct tctcttgcct     1440

tggcctggct gttggagccc tggcactggg gctctggctg aggctgagac ggagtgggaa     1500

ggaaggaccg caaaaacctg ggctcttggc acccatgatc ccggtggaaa agcttccagg     1560

aattccaaac ctgcagagga ccccagagaa cttcagctga tttcatctgt aacccggtca     1620

gacttgggtg gttaaaagga caggcagaaa gaggcggggc agtggatccc tgtggatgga     1680

ggtctcagct ggaagtctga gctcttttct ttgacaccta tactccaaac ttgctgccgg     1740

ctgaaggctg tctggacttc tgatgtcctg aggtggaagt ccacctgagg aatgtgtaca     1800

gaagtctgtg ttcctgtgat cgtgtgtgta tgtgagacag ggagcaaaag ttctctgcat     1860

gtgtgtacac atgattggag agtgtgtgcg gtcttgggct tggcccttct ggggagtgtg     1920

aagagttgaa ataaaagaga cggaagtttt tggagattgt cgtctaatgt tgctttatta     1980

gttttgctgt tgggggtgtg agtacatttt cttttgtagt accagattta aactgggtac     2040

agttccttgg agccttttcc cttggcgttc taaccaccga gccaggctgc ggttctgggg     2100

atgaacacag acactgcgcc gagccaggtg aagcctgaga agggaaaagt ccaaagctag     2160

gctcacattt gggggatgag cttaggtagg gttcaggggt taggggtaaa agcccgatga     2220

aaatccgggt aggtattaga gttagtaaag gggctaggga tgaatattgg gggttcggac     2280

tgagggcaga gttagaggta tcaaagttgg gggcagagct cacacgacag cctggaggtg     2340

acagtcccca tcagcctcct gcagttccat gtggacaatc ctcctcagca gcctgcttgg     2400

gagtggctgt ctatagagct gagtacagca gctagtgctg gagggcagag gcaaggctgg     2460

agaacaatag ggccacactt cagagaggtc tggacccaca agctgctctg attacatagc     2520

tagaggtcca actttctggg ccctgttccc tgtagtcccc tcgctcagca ttcattctat     2580

ggcctctgag aacttacctg cttcaggagc cgggctcaga agcaacagta acagcgggag     2640

gctgctggcg ggggagagcc cctccatcat gctcactcag                           2680


<210>  12
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  13
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Asn Ile Ala Ser Phe 
                325                 


<210>  14
<211>  9027
<212>  DNA
<213>  Homo sapiens

<400>  14
ggatctgaca gtgttccgga gccggggcga gcagccaaaa ggcccgcgga gtcgcgctgg       60

gccgccccgg cgcagctgaa ccgggggccg cgcctgccag gccgacgggt ctggcccagc      120

ctggcgccaa ggggttcgtg cgctgtggag acgcggaggg tcgaggcggc gcggcctgag      180

tgaaacccaa tggaaaaagc atgacattta gaagtagaag acttagcttc aaatccctac      240

tccttcactt actaattttg tgatttggaa atatccgcgc aagatgttga cgttgcagac      300

ttggctagtg caagccttgt ttattttcct caccactgaa tctacaggtg aacttctaga      360

tccatgtggt tatatcagtc ctgaatctcc agttgtacaa cttcattcta atttcactgc      420

agtttgtgtg ctaaaggaaa aatgtatgga ttattttcat gtaaatgcta attacattgt      480

ctggaaaaca aaccatttta ctattcctaa ggagcaatat actatcataa acagaacagc      540

atccagtgtc acctttacag atatagcttc attaaatatt cagctcactt gcaacattct      600

tacattcgga cagcttgaac agaatgttta tggaatcaca ataatttcag gcttgcctcc      660

agaaaaacct aaaaatttga gttgcattgt gaacgagggg aagaaaatga ggtgtgagtg      720

ggatggtgga agggaaacac acttggagac aaacttcact ttaaaatctg aatgggcaac      780

acacaagttt gctgattgca aagcaaaacg tgacaccccc acctcatgca ctgttgatta      840

ttctactgtg tattttgtca acattgaagt ctgggtagaa gcagagaatg cccttgggaa      900

ggttacatca gatcatatca attttgatcc tgtatataaa gtgaagccca atccgccaca      960

taatttatca gtgatcaact cagaggaact gtctagtatc ttaaaattga catggaccaa     1020

cccaagtatt aagagtgtta taatactaaa atataacatt caatatagga ccaaagatgc     1080

ctcaacttgg agccagattc ctcctgaaga cacagcatcc acccgatctt cattcactgt     1140

ccaagacctt aaacctttta cagaatatgt gtttaggatt cgctgtatga aggaagatgg     1200

taagggatac tggagtgact ggagtgaaga agcaagtggg atcacctatg aagatagacc     1260

atctaaagca ccaagtttct ggtataaaat agatccatcc catactcaag gctacagaac     1320

tgtacaactc gtgtggaaga cattgcctcc ttttgaagcc aatggaaaaa tcttggatta     1380

tgaagtgact ctcacaagat ggaaatcaca tttacaaaat tacacagtta atgccacaaa     1440

actgacagta aatctcacaa atgatcgcta tctagcaacc ctaacagtaa gaaatcttgt     1500

tggcaaatca gatgcagctg ttttaactat ccctgcctgt gactttcaag ctactcaccc     1560

tgtaatggat cttaaagcat tccccaaaga taacatgctt tgggtggaat ggactactcc     1620

aagggaatct gtaaagaaat atatacttga gtggtgtgtg ttatcagata aagcaccctg     1680

tatcacagac tggcaacaag aagatggtac cgtgcatcgc acctatttaa gagggaactt     1740

agcagagagc aaatgctatt tgataacagt tactccagta tatgctgatg gaccaggaag     1800

ccctgaatcc ataaaggcat accttaaaca agctccacct tccaaaggac ctactgttcg     1860

gacaaaaaaa gtagggaaaa acgaagctgt cttagagtgg gaccaacttc ctgttgatgt     1920

tcagaatgga tttatcagaa attatactat attttataga accatcattg gaaatgaaac     1980

tgctgtgaat gtggattctt cccacacaga atatacattg tcctctttga ctagtgacac     2040

attgtacatg gtacgaatgg cagcatacac agatgaaggt gggaaggatg gtccagaatt     2100

cacttttact accccaaagt ttgctcaagg agaaattgaa gccatagtcg tgcctgtttg     2160

cttagcattc ctattgacaa ctcttctggg agtgctgttc tgctttaata agcgagacct     2220

aattaaaaaa cacatctggc ctaatgttcc agatccttca aagagtcata ttgcccagtg     2280

gtcacctcac actcctccaa ggcacaattt taattcaaaa gatcaaatgt attcagatgg     2340

caatttcact gatgtaagtg ttgtggaaat agaagcaaat gacaaaaagc cttttccaga     2400

agatctgaaa tcattggacc tgttcaaaaa ggaaaaaatt aatactgaag gacacagcag     2460

tggtattggg gggtcttcat gcatgtcatc ttctaggcca agcatttcta gcagtgatga     2520

aaatgaatct tcacaaaaca cttcgagcac tgtccagtat tctaccgtgg tacacagtgg     2580

ctacagacac caagttccgt cagtccaagt cttctcaaga tccgagtcta cccagccctt     2640

gttagattca gaggagcggc cagaagatct acaattagta gatcatgtag atggcggtga     2700

tggtattttg cccaggcaac agtacttcaa acagaactgc agtcagcatg aatccagtcc     2760

agatatttca cattttgaaa ggtcaaagca agtttcatca gtcaatgagg aagattttgt     2820

tagacttaaa cagcagattt cagatcatat ttcacaatcc tgtggatctg ggcaaatgaa     2880

aatgtttcag gaagtttctg cagcagatgc ttttggtcca ggtactgagg gacaagtaga     2940

aagatttgaa acagttggca tggaggctgc gactgatgaa ggcatgccta aaagttactt     3000

accacagact gtacggcaag gcggctacat gcctcagtga aggactagta gttcctgcta     3060

caacttcagc agtacctata aagtaaagct aaaatgattt tatctgtgaa ttcagatttt     3120

aaaaagtctt cactctctga agatgatcat ttgcccttaa ggacaaaaat gaactgaagt     3180

ttcacatgag ctatttccat tccagaatat ctgggattct actttaagca ctacataaac     3240

tgactttatc ctcagactag ctgaatgatt ttgtgctgtt tcaggatgtt tgcactgaag     3300

aaaaacagaa agcttatctg aaatttataa aactttttgt tttgctacat agaaaacaga     3360

aggtatttga ataataagca gtgatatgct tagtgagcac agctatactg attttgatta     3420

gaatagtcat cagagtggct tagggacagt taatataaaa gaggagcaag gtgtagacca     3480

tcatctactt ctgctaaaat aacttaaaaa gaggtccata ggccataact acatgagccc     3540

agcttttgta atctgacaaa aaaatgagga gcagcttcgt gtatatcagt gtacacggta     3600

ttccttaggt cccttccatt ggtagtgatg ctgcgagtta ttactggaga aaaggaattc     3660

tagagcttta acttggcaga ttaaaagtac tcatttttta ttcatcaata attagtaatc     3720

tcactagttt tcaaaaattt gcatattatt gacaacctct ttgaagatgc atttcacaaa     3780

ctcaacagag tgccatgata agagctaggg atcccccaaa ctatctcaag catctaaaaa     3840

attgccattt ttaaaggctt aaattgtagt agtaaagggg aaaacaggaa gtagtagtaa     3900

aggggaaaaa aaaccaataa agcatctaaa aaattggcat gttaaaaggc ttaaattgct     3960

aatgtgtgta tatatatata tatatataca cacacatatc attgactttt cttaagactt     4020

cagagtactg ggtagatgaa cactttatac agtatatatc ttcagcttaa atttgttttg     4080

agtatttttt ttatttttaa ataagtaggc aaagatttaa atttttttat ttttagtaaa     4140

tgtttgaggc acactaagac aacttgggca atatttgcca aaacaaaaca gaaccccaaa     4200

aaatgtacat cttgttctta gcaaatatca ttattgtaga gacacttaat aaagagatgg     4260

tattttaatg tctgcagttc tgaggtaggg tggaacttag ttctacattg tgatttagga     4320

atttttaaaa ccttttttct tcaagggaga agtgacccag gcctcgagtt tagtgctaaa     4380

gccgctagtg tacttatgct gtcccctaac caccacgtgc gatatggaag cagatgctaa     4440

atataggggt tttcttagaa agtaagagga aattagcaag cgttattagt gattgactac     4500

tgctatcaag tgaattcaaa ggaaacaggt ttttatgcca tatttaagtt acagaaacca     4560

ggcatgctta gaatagtttc tagaggttat tggagaatag aaagctaaga aaacttggta     4620

tacatttaca atggaaatat aattacactt tttactctca gaatattgtt cacattagac     4680

ttcctgttta tcttttatat tcttgcattt atataatgcc tcatcctttc aaagttcttt     4740

cacatattat atgatcttct ttatgaaaaa aatagatgtt tcattctgat atattcagtt     4800

tcccacttta ggcaaaagta gattaataga atgacgaatt caaagtagat gaggaaaatc     4860

aggcacagag aagtaaaggt agggatagac ccaaatttac acaacaagat aatgacatct     4920

ccagctttta agttgatcat caaaggctgg gctggatttg tcttgctgta tgtgtcagga     4980

aatttatacc tattacattt tccattttct caaaatttaa gtcacatgac taatatttag     5040

ctgcaacttt cctcataaca aatagtgtca tgaagaatgt tgtagtgtga agtttgtaca     5100

tttcagggtc agatatacaa tatgaactct taatctacag gaatgagaat ggaggatcat     5160

tgaaggccat gatataaaca aatttgcatg ttgaagcctg tataaaacat ggtacagtga     5220

gtgaatatac ccccatcccc aagaacactt tatacatatt aaatggatat atgattactg     5280

tgcaaaaatt cattctggaa atgaacatat atttgagcac taatatgtaa tgtacacctg     5340

ccctaaggag aaaataaatt ataaaacttt ttacattcaa aattactttc ccaagcatgt     5400

cttagaataa tctatgtgtt gatgcatgta aattgtactt taggtaggca aagaaatctg     5460

gttatttatg taaaaactag tctaataaag ttagttagtg gctttatcac tttaaatctt     5520

tagtgtccaa aagtggtgtt taaagtaata gcacatcaga aaaccttgtc tggacaaaac     5580

tagttcactc actgcttctg cacctgcagt tgctcccttt agggttataa aataatgacc     5640

caaatgttac atgtgttgat attataactt gtcagttact gatgtctgtg gtatcctacc     5700

ctcatctctg aaagggataa tactgaataa ttattagaaa actataaaac ttcacacttt     5760

gtaccattaa aacctaaaat tttaatcttg tcctttttta ctatggatca gtcggcactc     5820

gggaacagca gcaaggaaaa aaagcaaatt tcattcacat gttctgtgtt catacctctt     5880

ctctacctaa ttgttcattt aaatttcagc cttattcctt gataagggat tttaccacat     5940

gaagtcatcc agtgacccta gctcttattg tgaagttagt ggagtatact tagaaatgtt     6000

acaactttaa aatgttacaa aacattcatt aaagctcata tttaaagtag agcatctagt     6060

ttgagaaata gaaatcaatt attaaagatg tcttttttct acccatttaa ctagttaaaa     6120

ccatgacatg taaatgtaga agtagaataa tcatagaatt ccctaaaata tttctgttta     6180

ctaacatata ttgaccaagt acatcaagca ggagagatct tccttcattc tgttatagtc     6240

cacatcattc taattttgct cagttgttat taagagcata ttcctaaacc atacactttt     6300

gtttcaataa agttttattt tgttgagatg aataaaataa caaagttata agctgcataa     6360

gacaaaagtt caattgttca aaaaaaattt actgggatag ctttctatta caggtattgt     6420

tagattatat tgtgctgata agattacttt ctaaaaaatt tgtacttttc tgtaaattaa     6480

aagaatatgg agtcataaaa tggcaagtgt tttaggatta gcctaaaatt ggacattgtc     6540

attgatttca aagaaggtat gaactagcag tcttacagcc taattcttct ttggactggt     6600

ccttggcagc agttcctttt cagactcgat aaacagaatt cagatgatgt aagtcaaaac     6660

aaaactttac aaagccaagc gtattatctt ttgcattaac ctattttttt ccatcataca     6720

tgctactagt atgtgcatta gcatgatatt ctcatataca ttgcattaaa aattaaaagg     6780

tggcagctca gggtgagctc ttctgttgct catttgttcc taaattttta agggcttttt     6840

ctcagtcaat agtttgtaca aactggttag tttaacttca ttacccattt cattaaagtt     6900

gatgggtcgt gtgatgagat gcatttaagg ccgatagtga tagatgtttt ttttatttct     6960

tgaacacagg ctttgtctga atgatgttct tttatctctt gaacacaagc tttgaatgat     7020

aactacaggt tttaagtgct gttacattaa taccataatg tgatgtgtta gaaacaaagg     7080

gatatttcaa aggtagatat ttgaaaattc tctagtctca atatgtatgt gtattgaata     7140

tactctaaaa ataaatgtgc aatttgctag taggacaatg cagtgactga ctagcattag     7200

gtatgtttct tttatatcct agctatgtcc cactttcttc taagtgcaat cctttcatgt     7260

tcacttgctg ttttacccca tctactctaa cttcatttgg aaggcttgtc tagagtatag     7320

catgtatttt tacctttgca gtgaattgca tgtgctaatt gtaaccacag ctatttttat     7380

gttgacataa ctccaaatgt tatattaaat gttctattat atattagctc taatccctta     7440

agtaaatttt aagaaataaa tacttgttca aatttttttt ctgtatgtgg ttactatcat     7500

ctgactatgc atatttgtaa cagcatttat cattagtggt gttagctaaa taagcatctt     7560

agtgtaaatg agatgcttcg tgtgggtttt gtgacatttt aaatgacata atggaatgtg     7620

atttaaaaga aaaccagtac actatcttgg tcttaataac atagaatgga gatggcaaat     7680

ttatccacta gttttccaga tttactattt aatagctgag gtctgaaatc gtagcatcct     7740

ccctcctagt ggacattaaa aaaaaaaaaa aaaaaaaaaa cctacttggt tgtcaagagc     7800

ccaagtatgg aggtgctgcg ccatcttgtg gcctgtctgt gcccaccctg cactctgctg     7860

gagtctccat ccttgttgca gtgagacttg aagttcaaga ttgatacatg gcatcctcct     7920

gctacttctt gaggttacta agtagtatat gaaactaatc agtcagcaag tccacctgga     7980

aggaaaagaa aatctcaact attaatgtgc cttcacattg tgattttgtc taaaaaaatg     8040

tagtgagtca aaaaacccac aagccagcca acagtaactc cttcacatat ataccagagt     8100

ttatagaaat aacatgtcag ctttgggcta tgtgctcctt tgtttaaaat cttctatttg     8160

gttatggctt gtataggctc aagcctgatt tctttaaggt gtggtggctc atcttatcct     8220

aatgtgtatg atagatacag tccatcctgc tttggaaaag attatgtaac tccttgagag     8280

catactcttt ctctagccca aaggcagtga gagagttttc ttgttcagga ttgcttaact     8340

ttccatttaa gctttttctt tttaaattaa tacaaacttc tacactttca aaatacgaaa     8400

tatattacaa ctgcgtatag gctcttccat acttaagtcc agtgcttggg caagttaatg     8460

gagtgaaaga ctacaagcaa agaggaactg aggtagaaaa agaagaatgt gtgaaagcag     8520

caggaagctc agccaactcg aaagcagggt gaacagcttg agtcctgttg ctgctgatcg     8580

gggttggctc ttggacaact tagtaagatc atggaaaggc tgcttgggtt ctccatagaa     8640

aagttctgtc tccatcaagg gaggaaaatg tacctttcaa ctcaaaattc aatatttgtt     8700

tttaaatata gctattttcc ccaaccgcta aagattttca acagatacga agccagagct     8760

tagttttaga aacctgtgga cattcaaacc tgattcttta ttccctgtga ctatggttat     8820

gtcattttac atgtcaaaaa agtgtatcta gaattgtcat ttcttatttt tgagcttttt     8880

ttagtgagaa ttatcccctc acttaaatgg ctttttattt aaacatctgt gcattctgta     8940

tgaaattgta gtctttctgg gataacatgg tgagctatat ggtggtaatc cacacacaca     9000

aaaataaaag ccaaaaaaaa accaaaa                                         9027


<210>  15
<211>  8844
<212>  DNA
<213>  Homo sapiens

<400>  15
ggatctgaca gtgttccgga gccggggcga gcagccaaaa ggcccgcgga gtcgcgctgg       60

gccgccccgg cgcagctgaa ccgggggccg cgcctgccag gccgacgggt ctggcccagc      120

ctggcgccaa ggggttcgtg cgctgtggag acgcggaggg tcgaggcggc gcggcctgag      180

tgaaacccaa tggaaaaagc atgacattta gaagtagaag acttagcttc aaatccctac      240

tccttcactt actaattttg tgatttggaa atatccgcgc aagatgttga cgttgcagac      300

ttggctagtg caagccttgt ttattttcct caccactgaa tctacaggtg aacttctaga      360

tccatgtggt tatatcagtc ctgaatctcc agttgtacaa cttcattcta atttcactgc      420

agtttgtgtg ctaaaggaaa aatgtatgga ttattttcat gtaaatgcta attacattgt      480

ctggaaaaca aaccatttta ctattcctaa ggagcaatat actatcataa acagaacagc      540

atccagtgtc acctttacag atatagcttc attaaatatt cagctcactt gcaacattct      600

tacattcgga cagcttgaac agaatgttta tggaatcaca ataatttcag gcttgcctcc      660

agaaaaacct aaaaatttga gttgcattgt gaacgagggg aagaaaatga ggtgtgagtg      720

ggatggtgga agggaaacac acttggagac aaacttcact ttaaaatctg aatgggcaac      780

acacaagttt gctgattgca aagcaaaacg tgacaccccc acctcatgca ctgttgatta      840

ttctactgtg tattttgtca acattgaagt ctgggtagaa gcagagaatg cccttgggaa      900

ggttacatca gatcatatca attttgatcc tgtatataaa gtgaagccca atccgccaca      960

taatttatca gtgatcaact cagaggaact gtctagtatc ttaaaattga catggaccaa     1020

cccaagtatt aagagtgtta taatactaaa atataacatt caatatagga ccaaagatgc     1080

ctcaacttgg agccagattc ctcctgaaga cacagcatcc acccgatctt cattcactgt     1140

ccaagacctt aaacctttta cagaatatgt gtttaggatt cgctgtatga aggaagatgg     1200

taagggatac tggagtgact ggagtgaaga agcaagtggg atcacctatg aagatagacc     1260

atctaaagca ccaagtttct ggtataaaat agatccatcc catactcaag gctacagaac     1320

tgtacaactc gtgtggaaga cattgcctcc ttttgaagcc aatggaaaaa tcttggatta     1380

tgaagtgact ctcacaagat ggaaatcaca tttacaaaat tacacagtta atgccacaaa     1440

actgacagta aatctcacaa atgatcgcta tctagcaacc ctaacagtaa gaaatcttgt     1500

tggcaaatca gatgcagctg ttttaactat ccctgcctgt gactttcaag ggaacttagc     1560

agagagcaaa tgctatttga taacagttac tccagtatat gctgatggac caggaagccc     1620

tgaatccata aaggcatacc ttaaacaagc tccaccttcc aaaggaccta ctgttcggac     1680

aaaaaaagta gggaaaaacg aagctgtctt agagtgggac caacttcctg ttgatgttca     1740

gaatggattt atcagaaatt atactatatt ttatagaacc atcattggaa atgaaactgc     1800

tgtgaatgtg gattcttccc acacagaata tacattgtcc tctttgacta gtgacacatt     1860

gtacatggta cgaatggcag catacacaga tgaaggtggg aaggatggtc cagaattcac     1920

ttttactacc ccaaagtttg ctcaaggaga aattgaagcc atagtcgtgc ctgtttgctt     1980

agcattccta ttgacaactc ttctgggagt gctgttctgc tttaataagc gagacctaat     2040

taaaaaacac atctggccta atgttccaga tccttcaaag agtcatattg cccagtggtc     2100

acctcacact cctccaaggc acaattttaa ttcaaaagat caaatgtatt cagatggcaa     2160

tttcactgat gtaagtgttg tggaaataga agcaaatgac aaaaagcctt ttccagaaga     2220

tctgaaatca ttggacctgt tcaaaaagga aaaaattaat actgaaggac acagcagtgg     2280

tattgggggg tcttcatgca tgtcatcttc taggccaagc atttctagca gtgatgaaaa     2340

tgaatcttca caaaacactt cgagcactgt ccagtattct accgtggtac acagtggcta     2400

cagacaccaa gttccgtcag tccaagtctt ctcaagatcc gagtctaccc agcccttgtt     2460

agattcagag gagcggccag aagatctaca attagtagat catgtagatg gcggtgatgg     2520

tattttgccc aggcaacagt acttcaaaca gaactgcagt cagcatgaat ccagtccaga     2580

tatttcacat tttgaaaggt caaagcaagt ttcatcagtc aatgaggaag attttgttag     2640

acttaaacag cagatttcag atcatatttc acaatcctgt ggatctgggc aaatgaaaat     2700

gtttcaggaa gtttctgcag cagatgcttt tggtccaggt actgagggac aagtagaaag     2760

atttgaaaca gttggcatgg aggctgcgac tgatgaaggc atgcctaaaa gttacttacc     2820

acagactgta cggcaaggcg gctacatgcc tcagtgaagg actagtagtt cctgctacaa     2880

cttcagcagt acctataaag taaagctaaa atgattttat ctgtgaattc agattttaaa     2940

aagtcttcac tctctgaaga tgatcatttg cccttaagga caaaaatgaa ctgaagtttc     3000

acatgagcta tttccattcc agaatatctg ggattctact ttaagcacta cataaactga     3060

ctttatcctc agactagctg aatgattttg tgctgtttca ggatgtttgc actgaagaaa     3120

aacagaaagc ttatctgaaa tttataaaac tttttgtttt gctacataga aaacagaagg     3180

tatttgaata ataagcagtg atatgcttag tgagcacagc tatactgatt ttgattagaa     3240

tagtcatcag agtggcttag ggacagttaa tataaaagag gagcaaggtg tagaccatca     3300

tctacttctg ctaaaataac ttaaaaagag gtccataggc cataactaca tgagcccagc     3360

ttttgtaatc tgacaaaaaa atgaggagca gcttcgtgta tatcagtgta cacggtattc     3420

cttaggtccc ttccattggt agtgatgctg cgagttatta ctggagaaaa ggaattctag     3480

agctttaact tggcagatta aaagtactca ttttttattc atcaataatt agtaatctca     3540

ctagttttca aaaatttgca tattattgac aacctctttg aagatgcatt tcacaaactc     3600

aacagagtgc catgataaga gctagggatc ccccaaacta tctcaagcat ctaaaaaatt     3660

gccattttta aaggcttaaa ttgtagtagt aaaggggaaa acaggaagta gtagtaaagg     3720

ggaaaaaaaa ccaataaagc atctaaaaaa ttggcatgtt aaaaggctta aattgctaat     3780

gtgtgtatat atatatatat atatacacac acatatcatt gacttttctt aagacttcag     3840

agtactgggt agatgaacac tttatacagt atatatcttc agcttaaatt tgttttgagt     3900

atttttttta tttttaaata agtaggcaaa gatttaaatt tttttatttt tagtaaatgt     3960

ttgaggcaca ctaagacaac ttgggcaata tttgccaaaa caaaacagaa ccccaaaaaa     4020

tgtacatctt gttcttagca aatatcatta ttgtagagac acttaataaa gagatggtat     4080

tttaatgtct gcagttctga ggtagggtgg aacttagttc tacattgtga tttaggaatt     4140

tttaaaacct tttttcttca agggagaagt gacccaggcc tcgagtttag tgctaaagcc     4200

gctagtgtac ttatgctgtc ccctaaccac cacgtgcgat atggaagcag atgctaaata     4260

taggggtttt cttagaaagt aagaggaaat tagcaagcgt tattagtgat tgactactgc     4320

tatcaagtga attcaaagga aacaggtttt tatgccatat ttaagttaca gaaaccaggc     4380

atgcttagaa tagtttctag aggttattgg agaatagaaa gctaagaaaa cttggtatac     4440

atttacaatg gaaatataat tacacttttt actctcagaa tattgttcac attagacttc     4500

ctgtttatct tttatattct tgcatttata taatgcctca tcctttcaaa gttctttcac     4560

atattatatg atcttcttta tgaaaaaaat agatgtttca ttctgatata ttcagtttcc     4620

cactttaggc aaaagtagat taatagaatg acgaattcaa agtagatgag gaaaatcagg     4680

cacagagaag taaaggtagg gatagaccca aatttacaca acaagataat gacatctcca     4740

gcttttaagt tgatcatcaa aggctgggct ggatttgtct tgctgtatgt gtcaggaaat     4800

ttatacctat tacattttcc attttctcaa aatttaagtc acatgactaa tatttagctg     4860

caactttcct cataacaaat agtgtcatga agaatgttgt agtgtgaagt ttgtacattt     4920

cagggtcaga tatacaatat gaactcttaa tctacaggaa tgagaatgga ggatcattga     4980

aggccatgat ataaacaaat ttgcatgttg aagcctgtat aaaacatggt acagtgagtg     5040

aatatacccc catccccaag aacactttat acatattaaa tggatatatg attactgtgc     5100

aaaaattcat tctggaaatg aacatatatt tgagcactaa tatgtaatgt acacctgccc     5160

taaggagaaa ataaattata aaacttttta cattcaaaat tactttccca agcatgtctt     5220

agaataatct atgtgttgat gcatgtaaat tgtactttag gtaggcaaag aaatctggtt     5280

atttatgtaa aaactagtct aataaagtta gttagtggct ttatcacttt aaatctttag     5340

tgtccaaaag tggtgtttaa agtaatagca catcagaaaa ccttgtctgg acaaaactag     5400

ttcactcact gcttctgcac ctgcagttgc tccctttagg gttataaaat aatgacccaa     5460

atgttacatg tgttgatatt ataacttgtc agttactgat gtctgtggta tcctaccctc     5520

atctctgaaa gggataatac tgaataatta ttagaaaact ataaaacttc acactttgta     5580

ccattaaaac ctaaaatttt aatcttgtcc ttttttacta tggatcagtc ggcactcggg     5640

aacagcagca aggaaaaaaa gcaaatttca ttcacatgtt ctgtgttcat acctcttctc     5700

tacctaattg ttcatttaaa tttcagcctt attccttgat aagggatttt accacatgaa     5760

gtcatccagt gaccctagct cttattgtga agttagtgga gtatacttag aaatgttaca     5820

actttaaaat gttacaaaac attcattaaa gctcatattt aaagtagagc atctagtttg     5880

agaaatagaa atcaattatt aaagatgtct tttttctacc catttaacta gttaaaacca     5940

tgacatgtaa atgtagaagt agaataatca tagaattccc taaaatattt ctgtttacta     6000

acatatattg accaagtaca tcaagcagga gagatcttcc ttcattctgt tatagtccac     6060

atcattctaa ttttgctcag ttgttattaa gagcatattc ctaaaccata cacttttgtt     6120

tcaataaagt tttattttgt tgagatgaat aaaataacaa agttataagc tgcataagac     6180

aaaagttcaa ttgttcaaaa aaaatttact gggatagctt tctattacag gtattgttag     6240

attatattgt gctgataaga ttactttcta aaaaatttgt acttttctgt aaattaaaag     6300

aatatggagt cataaaatgg caagtgtttt aggattagcc taaaattgga cattgtcatt     6360

gatttcaaag aaggtatgaa ctagcagtct tacagcctaa ttcttctttg gactggtcct     6420

tggcagcagt tccttttcag actcgataaa cagaattcag atgatgtaag tcaaaacaaa     6480

actttacaaa gccaagcgta ttatcttttg cattaaccta tttttttcca tcatacatgc     6540

tactagtatg tgcattagca tgatattctc atatacattg cattaaaaat taaaaggtgg     6600

cagctcaggg tgagctcttc tgttgctcat ttgttcctaa atttttaagg gctttttctc     6660

agtcaatagt ttgtacaaac tggttagttt aacttcatta cccatttcat taaagttgat     6720

gggtcgtgtg atgagatgca tttaaggccg atagtgatag atgttttttt tatttcttga     6780

acacaggctt tgtctgaatg atgttctttt atctcttgaa cacaagcttt gaatgataac     6840

tacaggtttt aagtgctgtt acattaatac cataatgtga tgtgttagaa acaaagggat     6900

atttcaaagg tagatatttg aaaattctct agtctcaata tgtatgtgta ttgaatatac     6960

tctaaaaata aatgtgcaat ttgctagtag gacaatgcag tgactgacta gcattaggta     7020

tgtttctttt atatcctagc tatgtcccac tttcttctaa gtgcaatcct ttcatgttca     7080

cttgctgttt taccccatct actctaactt catttggaag gcttgtctag agtatagcat     7140

gtatttttac ctttgcagtg aattgcatgt gctaattgta accacagcta tttttatgtt     7200

gacataactc caaatgttat attaaatgtt ctattatata ttagctctaa tcccttaagt     7260

aaattttaag aaataaatac ttgttcaaat tttttttctg tatgtggtta ctatcatctg     7320

actatgcata tttgtaacag catttatcat tagtggtgtt agctaaataa gcatcttagt     7380

gtaaatgaga tgcttcgtgt gggttttgtg acattttaaa tgacataatg gaatgtgatt     7440

taaaagaaaa ccagtacact atcttggtct taataacata gaatggagat ggcaaattta     7500

tccactagtt ttccagattt actatttaat agctgaggtc tgaaatcgta gcatcctccc     7560

tcctagtgga cattaaaaaa aaaaaaaaaa aaaaaaacct acttggttgt caagagccca     7620

agtatggagg tgctgcgcca tcttgtggcc tgtctgtgcc caccctgcac tctgctggag     7680

tctccatcct tgttgcagtg agacttgaag ttcaagattg atacatggca tcctcctgct     7740

acttcttgag gttactaagt agtatatgaa actaatcagt cagcaagtcc acctggaagg     7800

aaaagaaaat ctcaactatt aatgtgcctt cacattgtga ttttgtctaa aaaaatgtag     7860

tgagtcaaaa aacccacaag ccagccaaca gtaactcctt cacatatata ccagagttta     7920

tagaaataac atgtcagctt tgggctatgt gctcctttgt ttaaaatctt ctatttggtt     7980

atggcttgta taggctcaag cctgatttct ttaaggtgtg gtggctcatc ttatcctaat     8040

gtgtatgata gatacagtcc atcctgcttt ggaaaagatt atgtaactcc ttgagagcat     8100

actctttctc tagcccaaag gcagtgagag agttttcttg ttcaggattg cttaactttc     8160

catttaagct ttttcttttt aaattaatac aaacttctac actttcaaaa tacgaaatat     8220

attacaactg cgtataggct cttccatact taagtccagt gcttgggcaa gttaatggag     8280

tgaaagacta caagcaaaga ggaactgagg tagaaaaaga agaatgtgtg aaagcagcag     8340

gaagctcagc caactcgaaa gcagggtgaa cagcttgagt cctgttgctg ctgatcgggg     8400

ttggctcttg gacaacttag taagatcatg gaaaggctgc ttgggttctc catagaaaag     8460

ttctgtctcc atcaagggag gaaaatgtac ctttcaactc aaaattcaat atttgttttt     8520

aaatatagct attttcccca accgctaaag attttcaaca gatacgaagc cagagcttag     8580

ttttagaaac ctgtggacat tcaaacctga ttctttattc cctgtgacta tggttatgtc     8640

attttacatg tcaaaaaagt gtatctagaa ttgtcatttc ttatttttga gcttttttta     8700

gtgagaatta tcccctcact taaatggctt tttatttaaa catctgtgca ttctgtatga     8760

aattgtagtc tttctgggat aacatggtga gctatatggt ggtaatccac acacacaaaa     8820

ataaaagcca aaaaaaaacc aaaa                                            8844


<210>  16
<211>  199
<212>  PRT
<213>  Mus musculus

<400>  16

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Arg Val Val Ala Pro Gly Pro Pro Ala Gly Ser Pro Arg Val Ser 
            20                  25                  30          


Ser Asp Pro Arg Ala Asp Leu Asp Ser Ala Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Met Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Ser Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Thr Leu Gly Ser Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Val Asp Leu Met Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Pro Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Ala 
        115                 120                 125             


Leu Gln Ala Arg Leu Glu Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Ala Ala Pro Asp Gln Pro Val Ile Pro 
145                 150                 155                 160 


Leu Gly Pro Pro Ala Ser Ala Trp Gly Ser Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  17
<211>  199
<212>  PRT
<213>  Macaca fascicularis

<400>  17

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Ser Pro Arg Ala Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Glu Asp Thr Arg Gln Leu Thr Ile Gln Leu Lys Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Ser Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Met Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Thr Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Leu Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Thr Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  18
<211>  199
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Arg Val Val Ala Pro Gly Pro Pro Ala Gly Ser Pro Arg Val Ser 
            20                  25                  30          


Ser Asp Pro Arg Ala Asp Leu Asp Ser Ala Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Met Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Thr Leu Gly Ser Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Val Asp Leu Met Ser Tyr Phe Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Ala Gly Pro Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Ala 
        115                 120                 125             


Leu Gln Ala Arg Leu Glu Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Ala Ala Pro Asp Gln Pro Ala Val Pro 
145                 150                 155                 160 


Leu Gly Pro Pro Ala Ser Ala Trp Gly Ser Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  19
<211>  1949
<212>  DNA
<213>  Mus musculus

<400>  19
tgcctggccc ttgctgctca cactcacaaa cctcccctcc ccaggccgag gcccagctga       60

ccccctgggt cccccggcag cggacaggga agggttaaag cccccccccc cggctccctg      120

ccccctgccc tggggaaccc ctggcctgtg gggacatgaa ctgtgtttgt cgcctggtcc      180

tggtggtgct gagcctctgg ccagatagag tcgttgcccc tgggccacca gctggctccc      240

ctcgagtctc ttcagaccct cgagcagatc tggacagcgc tgttctccta acccgatccc      300

tcctggcaga cacacggcaa ctagctgcac agatgagaga caaattccca gctgacggag      360

atcacagtct ggactccctg cccaccttgg ccatgagcgc tgggacattg ggatctttgc      420

agcttcctgg tgtgctgaca aggcttcgag tagacttgat gtcctacctc cggcatgtac      480

aatggctgcg ccgtgcaggt ggtccttccc taaagactct ggagccagag ctgggtgccc      540

tgcaagcccg actggaacgg ctactccgcc gtttacagct cttgatgtct cgcctggcct      600

tgccccaggc agccccagac caacctgtga tccccctggg ccctcctgcc tcagcctggg      660

gaagcatccg ggcagctcat gccatcctag gagggctgca cctgaccttg gactgggccg      720

tgcggggcct gctgttgtta aagactcgac tgtgactcgg gactgaaaac caccatcgat      780

accgcccttt aaaaccagat cttatttatt tatttatttt ggtacttgga ggggggcatg      840

atgatcaggg gcatgccaca ccccaaacaa ccgccccaca cccagctaga cagtctttcc      900

agtagacctg ggtgaggggg atcacctgtg gcttatttat acttatttat ttaaacaatt      960

ggggggtggg tgggtgcatc tgagaccctg aagagcaggg aactgagatc ctgggttctg     1020

gggtctctat gaaatctgtt cacagtgtct tcctcacttc ctacattatt tattaaacga     1080

ttacttttta tattaagagg aggaaggagg gaagccgggc gtggtggcgc atgcctttaa     1140

tcccagcact cgggaggcag aggcaggcag atttctgagt tcgaggccag cctggtctaa     1200

gagtgagttc gtgagttcca ggacagccag ggctacacag agaaaccctg tctcgaaaaa     1260

ccaaaaaaaa aaaaaaaaaa aaagaggagg aaggaggggg aaaaaggaag cctggggttt     1320

tataccaaaa tgtgagtttt tttttgtgag tcagagaagt gagaggattt aaatacatat     1380

ctatttagag gttattagca ggagtatgcc gaaaggatcg gagtctaaac tggtacccta     1440

gcatttcaaa ggtcctcaac agatacttaa caaaaagttc cagagcatca ccttataact     1500

aatagcacct gtatggtaca gagctgtaag gtacaaggtt ttttgtttca gcaaaattca     1560

cgatgaccaa tgggaaacaa tctaggcttt ctggggggcg ggcaggggat ggatgaataa     1620

agctagggat acatccgcat gatgaagttc tagctcgcca accataaaaa ggcaagttcc     1680

aggcgaagac tgctttagat attgaacgtc tctgcgaccc aggagcagca gatggtagaa     1740

ctactctccc tatacatgag tatggactgt ttggtttttc aaaatggaaa caccatgatg     1800

ttgacgatag ctgcctcagg gctgaaaaca agcaatggca cagtgggtga ctgttactgt     1860

ttgtgtttgc attttccaga gttttcacca tgactgtatt ttgcaggaca catttataaa     1920

cattaataaa cactattttt agaaaaaaa                                       1949


<210>  20
<211>  2550
<212>  DNA
<213>  Macaca fascicularis

<400>  20
cgaccacccc cccctttccc ttttcaactt ttccaacttt tccttccgtg ccctcctccg       60

agcgcggcgg cgtgagccct gcaaggcagc cgctccgtgt gaatggaaaa ggcaggcagg      120

gagggtgagt caggatgtgt caggccgccc tcccctgccg cctgcccccc gcccgcccgc      180

cccagccccc tatataaccc cccaggcgtc cacactccct cactgcctcg gccctgctgc      240

tgacgggcac atgcctcccc tccccaggcc gcggcccagc tgacccccgg ggctcccccg      300

gcagcggaca gggaagggtt aaaggccccc ggctccctgc cccctgccct ggggaacccc      360

tggccctgcg gggacatgaa ctgtgtttgc cgcctggtcc tggtcgtgct gagcctgtgg      420

ccagatacag ctgttgcccc tgggccacca cctggctccc ctcgagcttc cccagaccct      480

cgggccgagc tggacagcac cgtgctcctg acccgctctc tcctggagga cacgcggcag      540

ctgactatac agctgaagga caaattccca gctgacgggg accacaacct ggattccctg      600

cccaccctgg ccatgagcgc gggggcactg ggagctctac agctcccgag tgtgctgaca      660

aggctgcgag cggacctact gtcctacctg cggcatgtgc agtggctgcg tcgggcaatg      720

ggctcttccc tgaagaccct ggagcctgag ctgggcaccc tgcagacccg gctggaccgg      780

ctgctgcgcc ggctgcagct cctgatgtcc cgcctggccc tgccccagct gcccccagac      840

ccgccggcgc ccccgctggc gcccccctcc tcaacctggg ggggcatcag ggccgcccac      900

gccatcctgg gggggctgca cctgacactt gactgggccg tgagggggct actgctgctg      960

aagactcggc tgtgacccga ggcccagagc caccaccgtc cttccaaagc cacatcttat     1020

ttatttattt atttcggtac tgggggcgaa acagccaggt gatccccctg cctttatctc     1080

cccctagtta gagacagtcc ttccgtgagg ctggggggca tctgtgcctt atttatactt     1140

atttatttca ggagcggggg tgggctcctg ggtccccgag gaggagggag ttggggtccc     1200

ggattcttgt gtccacagac ttctgccctg gctcctcccg ctcgaggcct gggcaggaat     1260

acatactatt tatttaagca attacttttc atgttggggt ggggagggag gggaaaggga     1320

agcctgggtt tttgtacaaa aatgtgagaa acctttgtga gacgaagaac aaggaattaa     1380

atgtgtcata catatccact tgagggcgac ttgtctgaga gctggggctg gatgctcggg     1440

taactggggc agggcaggtg gaggtcccga gtgggcgggg cagggactgg gagatgggtc     1500

agtcacccag acagctctgg ggaggcagag tttgagcctc gcctggggcc ccacactgca     1560

cagggctctt tgttttttga gatggagact ggctctgttg cctaggttgg agtgcagtgg     1620

cgcaatctaa actcactgca acctccacct cccgggttta atcgattctc ctgcctcagc     1680

ctcccgatta gctgggatca caggcgtgca ccaccacgcc cggctaatta tttatttctt     1740

ttgtattttc agtagagaca aggtttcacc atgttgacca ggctggtttc gaactcctga     1800

cctcaggtga tcctcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc     1860

gcacctgacc tatataggtc ttcaataaat atttaatgga aggttccaga agtcaccctg     1920

cgattaacgg tacccgtatg tgacaaagct gcaaggtcaa gatggttcat tatggctgtg     1980

ttgaccgtag caaattggaa acaatccaga tatccaacag gtgagggtta agcaacatgg     2040

tgcatcggtg gatggaatgc cacccggcca cccagagcag ggactagcat tcagggaggc     2100

taaggagaga ggcctgcttc ggatatagaa agatagcctg acattggcca ggcatggtgg     2160

tcacgcctgt aatcctagca ctctgggagg acgaagcaag tggatcactg aagtccaata     2220

gtttgagacc agcctgggag acgtggcgaa accctgtctc aaaagagaaa aaacgatgtc     2280

ctgacgtgaa acagctacaa aaccactgca tgatgcgatt ccaatttttg tgtttttctt     2340

tctatatatg gattaaaaaa aaaaaaaaaa ccctaaaggg aaataagcca aatgttgaca     2400

aggactgtct ccaggtcaaa ggagagaggt gggattgtgg gtgacttttg atgtttatga     2460

ttgtctgtat tttacagaat ttctgccatg actgtgtatt ttgcatgaca tattttaaaa     2520

ataataaaca ctatttttag aagaacagaa                                      2550


<210>  21
<211>  1675
<212>  DNA
<213>  Rattus norvegicus

<400>  21
gccgaggccc agctgacccc ctgggctccc ccggcagcgg acagggaagg gttaaaggcc       60

ccctcccccc ggctccctgc cccctgccct ggggaacccc tggcctgtgg ggacatgaac      120

tgtgtttgtc acctggtcct ggtggtgctg agcctctggc cagatagagt cgttgcccct      180

gggccaccag ctggctcccc tcgagtgtct tcagaccctc gtgcagatct ggatagcgct      240

gtcctcttga ccaggtccct cctggcagac acacggcaac tagctgcaca gatgagagac      300

aaattcccag ctgatggaga ccacaatctg gactccctac ctaccttggc catgagcgct      360

gggacactgg gatctttgca gcttcctgga gtgctgacaa ggcttcgagt agacttaatg      420

tcctacttcc gacatgtaca gtggttgcgc cgggcagctg gtccttccct aaagactctg      480

gagccagagc tgggtgccct gcaagcccga ctggaacggc tacttcgtcg cttacagctc      540

ttgatgtctc gcctagcctt gccccaggca gccccggacc aacctgcggt ccctctgggc      600

cctcctgcct cggcctgggg aagcatccgg gcagctcatg ccatcctagg agggctgcac      660

ctgaccttgg actgggccgt gcggggcctg ctgttgttaa agactcggct gtaactcagg      720

actgaaagcc accatcgaca tcgtccttta aagccagatc ttatttattt atttattttg      780

gtacttggag cgggggagca tgatgaacag gggcatgcca caccccaaac agccacaccc      840

agctagataa agtccttcca ggagacctgg gtgagggggc tcacctgtgg cttatttata      900

cttatttatt taaagaattg gggtgggtgc atctgagacc ctgaggagca gggaactgag      960

atcctgggtc ctgggtcttt acgaagtcta ttcacagtgt cttcctcact tttttattat     1020

ttattaaaca attacttttt atattaggag gatggagggg gggaaaggaa gcctggggtt     1080

tttataccaa aatgtgattt tttttttgtg acacagagaa gtggggtatt taactattaa     1140

tgtggggtat ataactattt agaggttatt agcaggaata ttccaaaggg atctgagtgt     1200

aaaccggtac cctagcactt caaaggtcct caacagatac ttagcaaacg gaccgaaaca     1260

cctcatgtct aacagcacct gcatggtaca gagatagcaa ggttcaaggt gtttcagcaa     1320

gagtcacgca ccctggcaaa tgggaaacaa cttaggtttt cggggggggg gggggggcag     1380

gggacggatg aatctagtta gggaagttcc aggcaaagac ttctttagat gttgaacgtc     1440

cctgtgcccc gagagcagca gaggatagaa cctctctttc tatacatgga tatagatttt     1500

ttttgttttt caaaatggaa acaccaaaat gttgacaaca gctgcctcag ggttgaaaac     1560

aagagatggc actgtgggtg actgttattg tttgtgcttg cattttccag agtttccacc     1620

atgactgtat tttgcatgac acgtttacaa acaataataa acactatttt tagaa          1675


<210>  22
<211>  455
<212>  PRT
<213>  Macaca fascicularis

<400>  22

Met Ser Ser Gly Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Ser Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Arg Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Thr Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Phe Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Arg Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Arg 
            260                 265                 270         


Pro Gly Val Glu Pro Ala Gly Leu Glu Glu Met Ile Thr Asp Ala Val 
        275                 280                 285             


Ala Gly Leu Pro His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp 
    290                 295                 300                 


Ala Gly Thr Trp Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser 
305                 310                 315                 320 


Thr Gly Thr Val Pro Lys Glu Val Pro Ala Trp Gly Gln Leu His Met 
                325                 330                 335     


Gln Pro Glu Val Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Ser Pro 
            340                 345                 350         


Ser Leu Gln Pro His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu 
        355                 360                 365             


Gln Val Ala Val Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu 
    370                 375                 380                 


Met Ala Gly Ala Leu Ala Leu Gly Leu Trp Ser Ser Lys Pro Ile Glu 
385                 390                 395                 400 


Asp Pro Gly Gly Leu Arg Gln Ser Pro Leu Ile Ile Leu Ser Cys Trp 
                405                 410                 415     


Cys Gly Trp Met Asp Ser Arg Ser Leu Trp Leu Gly Leu Ser Trp Lys 
            420                 425                 430         


Phe Cys Leu Glu Pro Ile Ser Val Arg Pro Cys Ile Ser Asn Leu Pro 
        435                 440                 445             


Ala Glu Arg Cys Leu Tyr Leu 
    450                 455 


<210>  23
<211>  431
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Met Ser Ser Ser Arg Ser Gly Leu Thr Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ser Ser Thr Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Pro Val Met Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Asn Ala Gly Thr Pro Val Ser Trp Phe Arg Asp Gly Asp 
    50                  55                  60                  


Ser Arg Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Arg Leu Val 
65                  70                  75                  80  


Leu Ala Gln Val Asp Ser Arg Asp Glu Gly Thr Tyr Val Cys Arg Thr 
                85                  90                  95      


Leu Asp Gly Val Phe Gly Gly Met Val Thr Leu Lys Leu Gly Ser Pro 
            100                 105                 110         


Pro Ala Arg Pro Glu Val Ser Cys Gln Ala Val Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Gly Arg Val Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Leu Pro Gly Ala Glu Ser Gln Arg 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Glu 
                165                 170                 175     


Ala Ser Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Glu Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Cys Leu Leu 
        195                 200                 205             


Asp Val Arg Leu Gln Arg Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu His Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Arg Arg Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ile Gly Leu Glu Glu Leu Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Ala Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Pro Leu 
305                 310                 315                 320 


Arg Asp Glu Val Pro Asp Gly Ser Arg Gly His Glu Gln Lys Leu Glu 
                325                 330                 335     


Ala Ala Ala Gln Glu Asp Ser Pro Ala Pro Pro Ser Pro Ser Leu Gln 
            340                 345                 350         


Pro Asp Pro Arg Pro Leu Asp His Arg Asp Pro Leu Glu Gln Val Ala 
        355                 360                 365             


Val Leu Ala Ser Leu Gly Ile Phe Ser Phe Leu Gly Leu Ala Val Gly 
    370                 375                 380                 


Ala Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Ser Gly Lys Asp 
385                 390                 395                 400 


Gly Pro Gln Lys Pro Gly Phe Leu Ala Pro Met Ile Pro Gly Asp Lys 
                405                 410                 415     


Leu Pro Gly Ile Pro Asn Leu Gln Arg Thr Pro Glu Asn Phe Ser 
            420                 425                 430     


<210>  24
<211>  3389
<212>  DNA
<213>  Macaca fascicularis

<400>  24
agagggcgag ggcagagggc gctggcggca gcggccgcgg aaggtgaggc ctggtgtaga       60

cgccaaagtc ttgtcacgag tgggcggggc agggtgatgt atgatctgaa aggccgagag      120

tgactgacga ctgtcagtgt gtgtgtgcct gtgagtctgt gtctgtgtga cagtatcatt      180

gtgtgcgatt ctgagtgtca cttggtgcag ctgtcagcta atgtgactgc gtgtgtcagt      240

gtgcatggag ctggggctgc atgtggctgt gcaagtgtgg gattatgtgt gtatctgtca      300

atgcacattt ttggtgggac tgggttgtgt gtttgtgtga gagggactgt gaccacatta      360

gggaatgtgt tttgggaagg tctctgtggg gtttgagacc atgtctgcca gcatgagagt      420

gggtggctgg ctttgtgtgt gccaatgtgt gacttcagca gtagcagagc aaaagtgagg      480

tttgtgacta tgtgtgtgtg ctgggtccta acttaaaccg tgtgggagta cagctgtatt      540

catgtattgg gggacctact tcaagagccc ataggactga cctttctctt aagtgtccag      600

catggacgga cacacccaca acacacgtgg cttcccctcc ttcttcctct gctcaagaat      660

ccccagcatc aggtctactg ctccttactt tctgtttccc tgcttgactc agtttccctt      720

acatgccgtt ttctctccct gttgctgtct tactagggat atctctgcgt gtttcttcat      780

agctttgttc ccctggtctc tgtgtggtgc atttccagtt ttgcctctcc tgtctctttg      840

tttctccctg tgcccctatg cctgccttcc ctgctgatct tgatctcttt ggctagttgg      900

gggcctgtaa cagtgatgag atgcaggtct gccactgcta agagctccct gagagagggg      960

gcttagaccg tgatgaggag ttgcttttag gcggtgctgt gagccctggt agggggctgt     1020

gtatgtgtgt gactgcgtga gtttatgaat atgtgtaagt gtatctgagt ctgaggctgt     1080

gtggctgtgc ctgtgtgact gtgagtgacc gcatgtgaga gtgtgtaagt ctgagggtaa     1140

ctgtgggtct tgtgtatctg gcaccaaggg accaaaggca tttcctggtg ctggggccca     1200

aagagtggag ggggaggtga gaaatggctg gaacttccag gggaggggga actgcactct     1260

ctggcctctc cttatatccc ccaacttggg gcctgctttc ccctggaagc acagccagct     1320

gtgccctaag gaaacatttg gtgaggagtg aaaagaggag gagtttatat ctgatttttc     1380

atttgattgt gtccacgtgt gttcaaaggc atgccctttt gttaactgtg cgtcatgagt     1440

ccatgtgtga atgtgactat gtctggctgt gtgaaaacac agggcatctc tcactgacag     1500

ggacataagt attagccacc ctcttttccc tcttgctggc cttggctgtg tctgtggctt     1560

cctttccaga cttgggggag gcctcttccc ttcacagggc cttgggtggg agggaaggag     1620

ggaggaggca gaagcgggga gggggcctgg ctaggggcgg cggagctcca gggcttagag     1680

ggggcggggc agggaagggg aaggagggga tggctttggg gtcccagaac tgagtggagt     1740

aggagacagg ggctgtagct ggtgagaagt cctggaggcc atggacactc tgctgctggg     1800

atcaccgaga tgagcagcgg ctgctcaggg ctgagcaggg tcctggtggc cgtggctaca     1860

gccctggtgt ctgcctcctc ctcctgcccc caggcctggg gccccccagg ggtccagtat     1920

gggcagcccg gcaggtccgt gaagctgtgt tgtcctggag tgactgctgg ggacccagtg     1980

tcctggtttc gggacgggga gccaaggctg ctccagggac ctgactctgg gctagggcat     2040

gaactggtcc tgacccaggc agacagcact gatgagggca cctacatctg ccagacgctg     2100

gatggtgcac ttgggggcac agtgaccctg cagctgggct accctccagc ccgccctgtt     2160

gtctcctgcc aagcagctga ctatgagaac ttctcttgca cttggagtcc cagccagatc     2220

agcggtttac ccacccgcta cctcacctcc tacaggaaga agacagttct aggagctgat     2280

agccagagga ggagtccatc cacagggccc tggccatgcc cacaggatcc cttaggtgct     2340

gcccgctgtg ttgtccacgg ggctgagttc tggagccagt accggattaa tgtgactgag     2400

gtgaacccac tgggcgccag cacacgcctg ctggatgtga gcttgcagag catcttgcgc     2460

cctgacccac cccagggcct gcgggtagag tcggtaccag gtttcccccg acgcctgcga     2520

gccagctgga cataccctgc ctcctggccg cgccagcccc atttcctgct caagttccgt     2580

ttgcagtacc gtccggcaca gcatccagcc tggtccacgg tgaggcctgg agtggagcca     2640

gctggactgg aggagatgat cacagatgct gtggctgggc tgccccatgc cgtacgagtc     2700

agtgcccggg actttctgga tgctggcacc tggagcacct ggagcccgga ggcctgggga     2760

actccgagca ctgggaccgt accaaaggag gtaccagctt ggggccagct acacatgcag     2820

ccagaggtgg agcctcaggt ggacagccct gctcctccaa gcccctccct ccaaccacac     2880

cctcggctac ttgatcacag ggactctgtg gagcaggtag ctgtgctggc gtctttggga     2940

atcctttctt tcctgggact gatggctgga gccctggcac tggggctctg gagctccaaa     3000

cctatagagg acccaggagg gcttcggcag agtccactta taattctgtc ttgctggtgt     3060

ggatggatgg acagtagatc cctatggttg ggtctcagct ggaagttctg tttggagccc     3120

atttctgtga gaccctgtat ttcaaatttg ccagctgaaa ggtgcctgta cctctgattt     3180

caccccagag ttggagttct gctcgaggaa tgtgtgtaat gtgtacatct gtgtccatgt     3240

gtgaccatgt gtctgtgagg cagggaacat atattctctg catgcatgta tgtaggtgcc     3300

tggggagtgt gtgtgggtcc ttggctcttg gcctttcccc ttgcaggggt tgcgcaggtg     3360

tgaataaaga gaataaggaa gttcttgga                                       3389


<210>  25
<211>  1713
<212>  DNA
<213>  Rattus norvegicus

<400>  25
ctcctgtagg agggagtctt ggaggccatg agcactcagt cactgtgatt ttcaagatga       60

gcagcagccg ctcagggctg accagggtcc tggtggccgt ggctacagcc ctggtgtctt      120

cctccacccc ctgcccccaa gcttggggtc ctccaggggt ccagtatggg cagcctggca      180

ggcccgtgat gctgtgctgc cccggagtga atgctgggac tccggtgtcc tggtttcggg      240

atggggactc gaggctgctc cagggacctg actctggact aggacacaga ctggtcttgg      300

cccaggtgga cagccgtgac gagggcactt acgtctgtcg gacgctggat ggtgtatttg      360

ggggcatggt gaccctgaag ctgggctccc ccccagctcg gccggaggtc tcctgccaag      420

cagtagacta tgaaaacttt tcttgtactt ggagtccagg ccgggtcagc ggtttgccca      480

cccgctacct tacttcctac aggaagaaga ccctgccagg agctgagagt cagagggaga      540

gtccgtctac cgggccttgg ccatgcccac aagaccccct ggaggcttcc cgatgtgtgg      600

tccacggggc agagttctgg agtgaatacc ggatcaatgt gactgaggtg aacccactgg      660

gcgccagcac gtgcctactg gatgtgagat tacagaggat cttacgtcct gatccacccc      720

aagggctgcg ggtggaatca gtacctggct acccgagacg cctgcatgcc agctggacat      780

accctgcctc ctggcgtcgc cagccccact tcctgctcaa gttccggttg caataccgtc      840

cagcacagca tccagcctgg tccacggtgg agcccattgg cttggaggag ttgataacag      900

atgccgtggc tgggctgccc catgcggtac gagtcagcgc cagggacttt ctggatgctg      960

gcacctggag tgcttggagc ccagaggcct ggggtactcc tagcaccggt cccctgcggg     1020

atgaggtacc tgatgggagc cggggacacg aacagaagct agaggcagca gctcaggagg     1080

acagccccgc tcctccaagc ccttccttgc agccagaccc aaggccactt gatcacaggg     1140

accccttgga gcaagtggct gtgttagcat ctctgggaat cttctctttc cttggcctgg     1200

ctgttggagc cctggctctg gggctctggc tgaggctgag gcggagtggg aaggacgggc     1260

ctcaaaagcc tggcttcttg gcaccaatga tcccagggga caagcttcca ggaatcccaa     1320

acctgcagag gaccccagag aacttcagct gatctcatct gcaaccctgt cagactgggg     1380

tggttaaatg gacaggcagg aggaggcagg acagcggatc cctatggatg gaggtctcag     1440

ttcgaagtct ggagcacttt tctttgacac ctgaactcca aacttgctgc cagctgctca     1500

ctctctggac ctctgatgcc gtccttgagg tggaagtccg cctgaggagc gtgtatcgaa     1560

gtctgtgtcc ctgtgactgt gtgtgtgtgt gatggggaga gcacgttctc cgtatgtgtg     1620

tgtatagatg attggagagt gtgtgtgtgg tcttgggctt ggctctcctg gggagcatgg     1680

agcgtgaaat aaagaggcgg acgtttttgg aaa                                  1713


<210>  26
<211>  917
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ser Ala Pro Arg Ile Trp Leu Ala Gln Ala Leu Leu Phe Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Ile Gly Gln Leu Leu Glu Pro Cys Gly Tyr Ile Tyr 
            20                  25                  30          


Pro Glu Phe Pro Val Val Gln Arg Gly Ser Asn Phe Thr Ala Ile Cys 
        35                  40                  45              


Val Leu Lys Glu Ala Cys Leu Gln His Tyr Tyr Val Asn Ala Ser Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Ala Ala Val Pro Arg Glu Gln Val Thr 
65                  70                  75                  80  


Val Ile Asn Arg Thr Thr Ser Ser Val Thr Phe Thr Asp Val Val Leu 
                85                  90                  95      


Pro Ser Val Gln Leu Thr Cys Asn Ile Leu Ser Phe Gly Gln Ile Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Val Thr Met Leu Ser Gly Phe Pro Pro Asp Lys 
        115                 120                 125             


Pro Thr Asn Leu Thr Cys Ile Val Asn Glu Gly Lys Asn Met Leu Cys 
    130                 135                 140                 


Gln Trp Asp Pro Gly Arg Glu Thr Tyr Leu Glu Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr Glu Lys Phe Pro Asp Cys Gln Ser Lys His 
                165                 170                 175     


Gly Thr Ser Cys Met Val Ser Tyr Met Pro Thr Tyr Tyr Val Asn Ile 
            180                 185                 190         


Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Ser Ser Glu 
        195                 200                 205             


Ser Ile Asn Phe Asp Pro Val Asp Lys Val Lys Pro Thr Pro Pro Tyr 
    210                 215                 220                 


Asn Leu Ser Val Thr Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu 
225                 230                 235                 240 


Ser Trp Val Ser Ser Gly Leu Gly Gly Leu Leu Asp Leu Lys Ser Asp 
                245                 250                 255     


Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ile Gln Val Pro Leu 
            260                 265                 270         


Glu Asp Thr Met Ser Pro Arg Thr Ser Phe Thr Val Gln Asp Leu Lys 
        275                 280                 285             


Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Ser Ile Lys Asp Ser Gly 
    290                 295                 300                 


Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Thr Thr Tyr 
305                 310                 315                 320 


Glu Asp Arg Pro Ser Arg Pro Pro Ser Phe Trp Tyr Lys Thr Asn Pro 
                325                 330                 335     


Ser His Gly Gln Glu Tyr Arg Ser Val Arg Leu Ile Trp Lys Ala Leu 
            340                 345                 350         


Pro Leu Ser Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Ile Leu 
        355                 360                 365             


Thr Gln Ser Lys Ser Val Ser Gln Thr Tyr Thr Val Thr Gly Thr Glu 
    370                 375                 380                 


Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Val Ala Ser Leu Ala Ala 
385                 390                 395                 400 


Arg Asn Lys Val Gly Lys Ser Ala Ala Ala Val Leu Thr Ile Pro Ser 
                405                 410                 415     


Pro His Val Thr Ala Ala Tyr Ser Val Val Asn Leu Lys Ala Phe Pro 
            420                 425                 430         


Lys Asp Asn Leu Leu Trp Val Glu Trp Thr Pro Pro Pro Lys Pro Val 
        435                 440                 445             


Ser Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Glu Asn Ala Pro Cys 
    450                 455                 460                 


Val Glu Asp Trp Gln Gln Glu Asp Ala Thr Val Asn Arg Thr His Leu 
465                 470                 475                 480 


Arg Gly Arg Leu Leu Glu Ser Lys Cys Tyr Gln Ile Thr Val Thr Pro 
                485                 490                 495     


Val Phe Ala Thr Gly Pro Gly Gly Ser Glu Ser Leu Lys Ala Tyr Leu 
            500                 505                 510         


Lys Gln Ala Ala Pro Ala Arg Gly Pro Thr Val Arg Thr Lys Lys Val 
        515                 520                 525             


Gly Lys Asn Glu Ala Val Leu Ala Trp Asp Gln Ile Pro Val Asp Asp 
    530                 535                 540                 


Gln Asn Gly Phe Ile Arg Asn Tyr Ser Ile Ser Tyr Arg Thr Ser Val 
545                 550                 555                 560 


Gly Lys Glu Met Val Val His Val Asp Ser Ser His Thr Glu Tyr Thr 
                565                 570                 575     


Leu Ser Ser Leu Ser Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala 
            580                 585                 590         


Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr 
        595                 600                 605             


Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys 
    610                 615                 620                 


Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn 
625                 630                 635                 640 


Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro 
                645                 650                 655     


Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg His 
            660                 665                 670         


Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr Asp 
        675                 680                 685             


Val Ser Val Val Glu Ile Glu Ala Asn Asn Lys Lys Pro Cys Pro Asp 
    690                 695                 700                 


Asp Leu Lys Ser Val Asp Leu Phe Lys Lys Glu Lys Val Ser Thr Glu 
705                 710                 715                 720 


Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser Arg 
                725                 730                 735     


Pro Ser Ile Ser Ser Asn Glu Glu Asn Glu Ser Ala Gln Ser Thr Ala 
            740                 745                 750         


Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His Gln 
        755                 760                 765             


Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro Leu 
    770                 775                 780                 


Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp Ser Val 
785                 790                 795                 800 


Asp Gly Gly Asp Glu Ile Leu Pro Arg Gln Ser Tyr Phe Lys Gln Asn 
                805                 810                 815     


Cys Ser Gln Pro Glu Ala Cys Pro Glu Ile Ser His Phe Glu Arg Ser 
            820                 825                 830         


Asn Gln Val Leu Ser Gly Asn Glu Glu Asp Phe Val Arg Leu Lys Gln 
        835                 840                 845             


Gln Gln Val Ser Asp His Ile Ser Gln Pro Tyr Gly Ser Glu Gln Arg 
    850                 855                 860                 


Arg Leu Phe Gln Glu Gly Ser Thr Ala Asp Ala Leu Gly Thr Gly Ala 
865                 870                 875                 880 


Asp Gly Gln Met Glu Arg Phe Glu Ser Val Gly Met Glu Thr Thr Ile 
                885                 890                 895     


Asp Glu Glu Ile Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            900                 905                 910         


Gly Tyr Met Pro Gln 
        915         


<210>  27
<211>  924
<212>  PRT
<213>  Macaca fascicularis

<400>  27

Met Lys Tyr Pro His Lys Met Leu Thr Leu Gln Thr Trp Val Val Gln 
1               5                   10                  15      


Ala Leu Phe Ile Phe Leu Thr Thr Glu Ser Ile Gly Glu Leu Leu Asp 
            20                  25                  30          


Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val Val Gln Leu His Ser 
        35                  40                  45              


Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys Cys Met Asp Tyr Phe 
    50                  55                  60                  


His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr Asn His Phe Thr Ile 
65                  70                  75                  80  


Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr Ala Ser Ser Val Thr 
                85                  90                  95      


Phe Thr Asp Ile Ser Ser Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu 
            100                 105                 110         


Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser 
        115                 120                 125             


Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser Cys Ile Val Asn Glu 
    130                 135                 140                 


Gly Lys Lys Met Arg Cys Glu Trp Asn Arg Gly Arg Glu Thr His Leu 
145                 150                 155                 160 


Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala Thr His Lys Phe Ala 
                165                 170                 175     


Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr 
            180                 185                 190         


Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp Val Glu Ala Glu Asn 
        195                 200                 205             


Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn Phe Asp Pro Val Tyr 
    210                 215                 220                 


Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu 
225                 230                 235                 240 


Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys 
                245                 250                 255     


Ser Val Ile Arg Leu Lys Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala 
            260                 265                 270         


Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser 
        275                 280                 285             


Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg 
    290                 295                 300                 


Ile Cys Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser 
305                 310                 315                 320 


Glu Glu Ala Asn Gly Ile Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro 
                325                 330                 335     


Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Ala Gln Gly Tyr Arg Thr 
            340                 345                 350         


Val Gln Leu Met Trp Lys Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys 
        355                 360                 365             


Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp Lys Ser His Leu Gln 
    370                 375                 380                 


Asn Tyr Thr Val Asn Asp Thr Lys Leu Thr Val Asn Leu Thr Asn Asp 
385                 390                 395                 400 


Arg Tyr Val Ala Thr Leu Thr Ala Arg Asn Leu Val Gly Lys Ser Asp 
                405                 410                 415     


Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe Gln Ala Thr His Pro 
            420                 425                 430         


Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn Met Leu Trp Val Glu 
        435                 440                 445             


Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys 
    450                 455                 460                 


Val Leu Ser Asp Lys Ala Pro Cys Ile Ala Asp Trp Gln Gln Glu Asp 
465                 470                 475                 480 


Gly Thr Val His Arg Thr His Leu Arg Gly Asn Leu Ala Glu Ser Lys 
                485                 490                 495     


Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser 
            500                 505                 510         


Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly 
        515                 520                 525             


Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val Leu Glu 
    530                 535                 540                 


Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr 
545                 550                 555                 560 


Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val Asn Val 
                565                 570                 575     


Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr 
            580                 585                 590         


Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp 
        595                 600                 605             


Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile 
    610                 615                 620                 


Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu 
625                 630                 635                 640 


Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His 
                645                 650                 655     


Ile Trp Pro Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp 
            660                 665                 670         


Ser Pro His Thr Pro Pro Arg His Asn Phe Ser Ser Lys Asp Gln Met 
        675                 680                 685             


Tyr Ser Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala 
    690                 695                 700                 


Asn Asp Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe 
705                 710                 715                 720 


Lys Lys Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly 
                725                 730                 735     


Ser Ser Cys Met Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu 
            740                 745                 750         


Asn Glu Ser Ser Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val 
        755                 760                 765             


Val His Ser Gly Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser 
    770                 775                 780                 


Arg Ser Glu Ser Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu 
785                 790                 795                 800 


Asp Leu Gln Leu Val Asp His Val Asp Gly Ser Asp Asp Ile Leu Pro 
                805                 810                 815     


Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro 
            820                 825                 830         


Asp Ile Ser His Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu 
        835                 840                 845             


Glu Asp Phe Val Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln 
    850                 855                 860                 


Ser Cys Gly Ser Gly Glu Met Lys Met Phe Gln Glu Val Ser Ala Ala 
865                 870                 875                 880 


Asp Pro Phe Gly Pro Gly Thr Glu Gly Gln Ile Glu Arg Phe Glu Thr 
                885                 890                 895     


Ile Gly Met Glu Ala Ala Ile Asp Glu Gly Met Pro Lys Ser Tyr Leu 
            900                 905                 910         


Pro Gln Thr Val Arg Gln Gly Gly Tyr Met Pro Gln 
        915                 920                 


<210>  28
<211>  918
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Met Ser Ala Leu Arg Ile Trp Leu Met Gln Ala Leu Leu Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Ile Gly Gln Leu Val Glu Pro Cys Gly Tyr Ile Tyr 
            20                  25                  30          


Pro Glu Phe Pro Val Val Gln Arg Gly Ser Asn Phe Thr Ala Thr Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Leu Gln Val Tyr Ser Val Asn Ala Thr Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Val Ala Val Pro Lys Glu Gln Val Thr 
65                  70                  75                  80  


Val Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Val Val Phe 
                85                  90                  95      


Gln Asn Val Gln Leu Thr Cys Asn Ile Leu Ser Phe Gly Gln Ile Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Leu Ser Gly Tyr Pro Pro Asp Ile 
        115                 120                 125             


Pro Thr Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Asn Met Leu Cys 
    130                 135                 140                 


Gln Leu Asp Pro Gly Arg Glu Thr Tyr Leu Glu Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr Glu Lys Phe Pro Asp Cys Arg Thr Lys His 
                165                 170                 175     


Gly Thr Ser Ser Cys Met Met Gly Tyr Thr Pro Ile Tyr Phe Val Asn 
            180                 185                 190         


Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Asn Val Ser Ser 
        195                 200                 205             


Glu Pro Ile Asn Phe Asp Pro Val Asp Lys Val Lys Pro Ser Pro Pro 
    210                 215                 220                 


His Asn Leu Ser Val Thr Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys 
225                 230                 235                 240 


Leu Ala Trp Val Asn Ser Gly Leu Asp Ser Ile Leu Arg Leu Lys Ser 
                245                 250                 255     


Asp Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ile Gln Val Pro 
            260                 265                 270         


Leu Glu Asp Thr Val Ser Pro Arg Thr Ser Phe Thr Val Gln Asp Leu 
        275                 280                 285             


Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Ser Ile Lys Glu Asn 
    290                 295                 300                 


Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Thr Thr 
305                 310                 315                 320 


Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Val Asn 
                325                 330                 335     


Ala Asn His Pro Gln Glu Tyr Arg Ser Ala Arg Leu Ile Trp Lys Thr 
            340                 345                 350         


Leu Pro Leu Ser Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Val 
        355                 360                 365             


Leu Thr Gln Ser Lys Ser Val Ser Gln Thr Tyr Thr Val Asn Gly Thr 
    370                 375                 380                 


Glu Leu Ile Val Asn Leu Thr Asn Asn Arg Tyr Val Ala Ser Leu Ala 
385                 390                 395                 400 


Ala Arg Asn Val Val Gly Lys Ser Pro Ala Thr Val Leu Thr Ile Pro 
                405                 410                 415     


Gly Ser His Phe Lys Ala Ser His Pro Val Val Asp Leu Lys Ala Phe 
            420                 425                 430         


Pro Lys Asp Asn Leu Leu Trp Val Glu Trp Thr Pro Pro Ser Lys Pro 
        435                 440                 445             


Val Asn Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Glu Asn Ser Pro 
    450                 455                 460                 


Cys Ile Pro Asp Trp Gln Gln Glu Asp Gly Thr Val Asn Arg Thr His 
465                 470                 475                 480 


Leu Arg Gly Ser Leu Leu Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr 
                485                 490                 495     


Pro Val Phe Pro Gly Gly Pro Gly Ser Pro Glu Ser Met Lys Ala Tyr 
            500                 505                 510         


Leu Lys Gln Ala Ala Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys 
        515                 520                 525             


Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp His Leu Pro Val Asp 
    530                 535                 540                 


Val Gln Asn Gly Phe Ile Arg Asn Tyr Ser Ile Ser Tyr Arg Thr Ser 
545                 550                 555                 560 


Val Gly Lys Glu Met Val Val Arg Val Asp Ser Ser His Thr Glu Tyr 
                565                 570                 575     


Thr Leu Ser Ser Leu Ser Ser Asp Thr Leu Tyr Met Val His Met Ala 
            580                 585                 590         


Ala Tyr Thr Glu Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr 
        595                 600                 605             


Thr Leu Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val 
    610                 615                 620                 


Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe 
625                 630                 635                 640 


Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
                645                 650                 655     


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            660                 665                 670         


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Ala Asn Phe Thr 
        675                 680                 685             


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asn Lys Lys Pro Cys Pro 
    690                 695                 700                 


Asp Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Ser Thr 
705                 710                 715                 720 


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                725                 730                 735     


Arg Pro Ser Ile Ser Ser Ser Glu Glu Asn Glu Ser Ala Gln Ser Thr 
            740                 745                 750         


Ala Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        755                 760                 765             


Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
    770                 775                 780                 


Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp Ser 
785                 790                 795                 800 


Val Asp Ser Gly Asp Glu Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                805                 810                 815     


Ser Cys Ser Gln Pro Gly Ala Ser Pro Asp Val Ser His Phe Gly Arg 
            820                 825                 830         


Ser Ser Gln Val Pro Ser Gly Ser Glu Glu Asp Phe Val Arg Leu Lys 
        835                 840                 845             


Gln Gln Gln Val Ser Asp His Ile Ser Glu Pro Tyr Gly Ser Glu Gln 
    850                 855                 860                 


Arg Arg Leu Phe Gln Glu Gly Ser Val Ala Asp Ala Leu Gly Thr Gly 
865                 870                 875                 880 


Thr Asp Gly Gln Ile Glu Arg Phe Glu Ser Val Gly Met Glu Thr Ala 
                885                 890                 895     


Met Asp Glu Asp Ile Ser Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  29
<211>  5452
<212>  DNA
<213>  Mus musculus

<400>  29
ggggccgtgg ggggcggagc taggagagcc cgggtcagcg gcggacggag ggtggcgtgt       60

gcggtcggga ggccagagct tcgagccatc cgggctgcgg ctccgctgag ggaccggtgg      120

tgtgggccgg gatccgcggg gctgagggac gctcaggagc ggcgaggctc gcgtccggaa      180

ggaagacccg atagaaggaa catgacatct agaggcagcg aacttgtttc cgattcatgc      240

tttatcattt cttaatttcg tatgttggga acatccctgc aagatgtcag caccaaggat      300

ttggctagcg caagctttgc tttttttcct caccactgaa tctataggtc aacttttgga      360

accgtgtggt tacatctacc ctgaatttcc agttgtccag cgcggctcga acttcactgc      420

catttgtgtg ctgaaggagg cgtgtctgca gcattactac gtgaatgcca gctacatcgt      480

gtggaagacc aaccatgctg ctgttcccag ggagcaggtc actgtcatca acagaaccac      540

gtccagtgtc acgttcacag acgtggtcct cccgagcgtg cagctcacct gcaacatcct      600

gtcctttggg cagatcgagc agaatgtgta tggagtcacc atgctttcag gctttcctcc      660

agataaacct acaaatttga cttgcattgt gaatgagggg aagaatatgc tgtgccagtg      720

ggaccccgga agggagactt accttgaaac aaactacact ttgaaatcag agtgggcaac      780

agagaagttt cctgattgcc agtcaaagca tggcacttca tgtatggtca gctacatgcc      840

cacctattat gtcaacattg aagtctgggt ggaagcagag aatgcccttg ggaaggtctc      900

ctcagagtct atcaattttg accccgtgga taaagtgaaa cccaccccac catataattt      960

atcagtgacc aactcagaag aattatccag tatattaaag ctatcatggg tcagttcagg     1020

gctgggcggt cttttagatc taaagtctga catccaatat aggaccaaag atgcctcaac     1080

ttggatccag gtccctcttg aagatacaat gtctcctcga acttccttca ctgtgcagga     1140

cctcaagcct tttacagaat atgtgtttag gatccggtcc attaaggaca gtgggaaggg     1200

ctactggagt gactggagtg aggaggctag tgggaccaca tacgaagaca gaccatccag     1260

accaccaagt ttctggtata agacaaatcc atcccatggg caggaatata gatctgtacg     1320

gctcatatgg aaggcactgc ctctttctga agccaatggg aaaatcttgg attatgaagt     1380

gattcttacg cagtcaaagt ccgtctcaca aacgtacaca gtcactggca cagagctgac     1440

cgtgaatctc accaatgacc gctatgtcgc gtctctagca gcaagaaaca aggtgggcaa     1500

atcagctgca gctgtcctca ccatccccag cccccacgtc acagctgctt attctgtagt     1560

gaatcttaaa gcatttccaa aagataacct gctctgggtg gaatggacac ctccacctaa     1620

acccgtgagc aagtacatct tagagtggtg tgtgttgtca gagaacgcac cctgtgttga     1680

agactggcag caggaagacg ctaccgtgaa tcggacccac ttgagaggac gcctcctgga     1740

gagcaagtgc tatcaaatca cagtaactcc cgtattcgcc acggggcccg gaggctctga     1800

gtccttgaag gcgtacctca aacaagccgc tcctgccaga ggaccgactg ttcggacaaa     1860

gaaagtgggg aaaaatgaag ctgtcttagc gtgggaccag attcctgtgg acgaccagaa     1920

tggcttcatt agaaactact ccatatctta cagaaccagc gtgggaaagg agatggttgt     1980

gcatgtggat tcttctcaca cggagtacac gctgtcctct ctgagtagtg atacgttgta     2040

catggtccga atggccgcgt acacagatga aggtgggaaa gatgggccgg aattcacttt     2100

tacaacacca aagttcgctc aaggagaaat agaagccata gtcgtgcctg tgtgcttagc     2160

cttcctcctg acaaccctgc tgggcgtctt gttctgcttt aacaaacgag acctaattaa     2220

aaaacacatc tggcctaatg ttcctgatcc ttccaagagt catattgccc agtggtcacc     2280

tcacaccccc ccaaggcaca attttaactc caaagatcaa atgtactcgg acggcaattt     2340

cactgatgta agcgttgtgg aaatagaagc aaacaacaag aagccttgtc cagatgacct     2400

gaagtccgtg gacctgttca agaaggagaa agtgagtaca gaagggcaca gcagtggcat     2460

cgggggctct tcatgcatgt cctcctccag gcccagcatc tccagcaacg aggagaatga     2520

gtctgctcag agcaccgcca gcacggtgca gtactccact gtggtgcaca gcggctacag     2580

gcaccaggtc ccgtccgtgc aagtgttctc aaggtccgag tccacccagc ccctgctaga     2640

ctcggaggag cggccagaag acctgcagct ggtggatagt gtagacggtg gggatgagat     2700

cttgcccagg caaccgtatt tcaagcagaa ctgcagtcag cctgaagcct gtccagagat     2760

ttcacatttt gaaaggtcaa accaggtttt gtccggcaat gaggaggatt ttgtcagact     2820

gaagcagcag caggtttcag atcacatttc tcagccctat ggatccgagc aacggaggct     2880

gtttcaggaa ggctctacag cggatgctct tggcacgggg gctgatggac agatggagag     2940

atttgaatct gttggaatgg agaccacaat tgatgaagaa attcccaaaa gttacttgcc     3000

acagactgta agacaaggtg gctacatgcc gcagtgaagg actggctcct gaacttcagc     3060

aggaactgca aaataaagct aaagacgagt ggcttcagat gagaaacagt cctcactccc     3120

tgaagatagg cattgcctct aaggacaaag tcacacctgg gccgtctcca ttccagagta     3180

gctggaattc tccttcaagc actacatgaa ctgactttat cctctatagc tggaggactc     3240

tgtgctcttt cagaatgttt gcactgccga aaacaaagtg tgtctgagtt tataaagctg     3300

ttggtttgct acatagaaaa cgggggattt aaatgagcca caatgtcatg gcatcgttca     3360

gctgggctgg ttttgatgag actgaccatc cagatgccag cgagaaggcc agcagcatca     3420

tttaaaagtg ccctgtggca cagtgtccag attatgtcat ctagaagacg aaagaatgga     3480

ggggtggctc gtttctgggt ctgtcagaga agcatggcct gctccttgct gttggtatcg     3540

atgccggtta ctactgagga agaggataaa ctttaaagag aagcaacata gaagcacccg     3600

ctttcttata gtcacctaca gcctcccaag aaactgctta ttattgaaaa tgtctttccg     3660

agtcaatttc atccacccta tagtggacca ggctggcctc aaactcagag atctgtctgc     3720

ctctgcctct gcctctgcct ccagagtacc gggatgaaag gcagtgcacc accactgctc     3780

cacttacgaa gattgctgtt tttaaagact taagttgttg acatttttct gaacacacat     3840

aaccacacca gggacagatg attctagaga ctggttgagg aagcacttta tccagaatgt     3900

cttcaacttt aaattacttt aattgactcc accttgtttt gattttcaag aatagcaggg     3960

tgtttgttga agggtggcat ttcccagagc ctcatgcagt cccagaacac acatcccaac     4020

catgtcagcg accaccacaa tgacagaagt cctcctacag agctgaggaa gctggaaggg     4080

tcctgctagt ttgcagggtg ggctttgaac ccacagccct gtgcatgcta gacattcact     4140

ctaccgctga gctgctcctc cgcccggctc attatgtcat ctaggctctc gtgatcctcc     4200

tggcccagct tcctgactgt ctgggactgt ggatgtgtgc tgtcacacac ccaaccaggt     4260

ctttttaata tctgccattt atgaggtaga gtttttacac gacttaggac tatcttaaac     4320

ctattccttc tagttgcttt attaaggaat agcctaggca tccagtgttt agcactaaag     4380

ccattaatgt atttgtgcct aacttcccag tgtgacatgg aggtgggggc taaaggtaga     4440

cactgggcag acaggaattg gctgagcgcc gttagaggct gatcactaag tgtgctcaca     4500

ggaaaagggt tgaagtttca gagcatgggc acccagatca tttatagcgg ttaccacaca     4560

gtgcctagga ggagttgata tgcacttagt tggatgcagt ttcacctttt actctcagaa     4620

ggttgtttat attctacttg ctgatgtgtt atcatttata tttttatact gggtagtcct     4680

tttctgtgtt ctttcacatg tataatcctc gtgagactgt acatgctttg ctctggtata     4740

ttcagttgcc tccttggcaa aaccagcctg gaattgccaa aatgccggaa gtgaagggag     4800

atggtgaaag tcgggcacag gaaggccagg tcaggggcag agagaccaga attcacacta     4860

caaggctggc accattgcca ttcaagttgg acgtcaaagc ctgatcccag ttaggactga     4920

gttttctatg tatatatctg ccaggaagtt aacacttgct gaatttctca tcttctcaca     4980

gtaagcagtc tagttatggg actctatcca tgttcagctg tgacttccct catatcagac     5040

agtggtgctg tgaacgttgc agtgtgaagt ctgtactggc tagggatggt agcccagcgt     5100

gagttcaggc atgaacatag aggccactga aggaagagcc tcctggaagc aagttggcac     5160

gttaaatccc agacagaaag tgtcccaggg agccagggcc tccgccagca gggagggggt     5220

gtgctcactg caggaacgtt catttagaag atgtaccatg gagcacctcc ctttgctcta     5280

agagaaaacc catcttaaag ttcatcttga atacagactt cgctcgagca tgttttagaa     5340

taatctggat gctgtacctt gtaccttagg tagcagagaa agtaatctgg cgtctttctg     5400

taaaaccgtc taataaagct agttctgccc gtgggctcgt attctttcgt gt             5452


<210>  30
<211>  7509
<212>  DNA
<213>  Macaca fascicularis

<400>  30
ggggagcgcc ccgccccgcc gcgggactgg ggcggcgcgc tacctctgcg gagaaggatc       60

cgcgagcgtt ccggagccgg ggcgagcagc caaaaggccc gcggagccgc gctgggccgc      120

cccggtgcag ctgaaccggg ggccgcgcct gccaggccga cggctctggc ccagcctggc      180

gccaagggtt tcgtgcgctg tggagacgcg gagggtcgag gcggcgcggc ctgagtgaaa      240

cccaatggaa aaagcatgac atttagaagc agaagactta gcttcaaatc cctactcctt      300

cacttagtga ttttgtgatt tgggtatctt ttaaggagac atattatgaa atatccgcac      360

aagatgttga cgttgcagac ttgggtagtg caagccttgt ttatttttct caccactgaa      420

tcaataggtg aacttctaga tccatgtggt tatatcagtc ctgaatctcc agttgtacaa      480

cttcattcta atttcactgc agtttgtgtg ctaaaggaaa aatgtatgga ttattttcat      540

gtaaatgcta attacattgt ctggaaaaca aaccatttta ctattcctaa ggagcaatat      600

actatcataa acagaacagc ctccagtgtc acctttacag atatatcttc attaaatatt      660

cagctcactt gcaacatcct tacatttgga cagcttgaac agaatgttta tggaatcaca      720

ataatttcag gcttgcctcc agaaaaacct aaaaatttga gttgcattgt gaatgaggga      780

aagaaaatga ggtgtgagtg gaatcgtgga agggaaacac acttggagac aaacttcact      840

ttaaaatctg aatgggcaac acacaagttt gctgattgca aagcaaaacg tgacaccccc      900

acctcatgca ctgttgatta ttctactgtg tattttgtca acattgaagt ctgggtagaa      960

gcagagaatg cccttgggaa ggttacatca gatcatatca attttgatcc tgtatataaa     1020

gtgaagccca atccgccaca taatttatca gtgatcaact cagaggaact gtctagtatc     1080

ttaaaattga catggaccaa cccaagtatt aagagtgtta taagactaaa atataacatt     1140

caatatagga ccaaagatgc ctcaacttgg agccagattc cccctgaaga tacagcatcc     1200

acccgatctt cattcactgt ccaagacctt aaacctttta cagaatatgt gtttaggatt     1260

tgctgtatga aggaagatgg taagggatac tggagtgact ggagtgaaga agcaaatggg     1320

atcacctatg aagatagacc atctaaagca ccaagtttct ggtataaaat agatccatcc     1380

catgctcaag gatatagaac tgtacaactc atgtggaaga cattgcctcc ttttgaagcc     1440

aatggaaaaa tcttggatta tgaagtgact ctcacaagat ggaaatcaca tttacaaaat     1500

tatacagtta atgacacaaa actgacagta aatctcacaa atgatcgcta tgtagcaacc     1560

ctaacagcaa ggaatcttgt tggcaaatca gatgcagctg ttttaactat ccctgcctgt     1620

gactttcaag ctactcaccc tgtaatggat cttaaagcat tccccaaaga taacatgctt     1680

tgggtagaat ggactactcc aagggaatct gtaaagaaat atatacttga gtggtgtgtg     1740

ttatcagata aagcgccctg tatcgcagac tggcaacagg aagatggtac tgtgcatcgc     1800

acccatttaa gagggaactt agcagagagc aaatgctatt tgataacagt tactccagta     1860

tatgctgacg gaccaggaag ccctgaatcc ataaaggcat accttaaaca agctccacct     1920

tccaaaggac ctactgttcg gacaaagaaa gtagggaaaa acgaagctgt cttagagtgg     1980

gaccaacttc ctgttgatgt tcagaatgga tttatcagaa attatactat attttataga     2040

accatcattg gaaatgaaac cgctgtgaat gtggattctt cccacacaga atatacattg     2100

tcctctttga ctagtgacac attgtacatg gtacgaatgg cagcatacac agatgaaggt     2160

gggaaggatg gtccagaatt cacttttact accccaaagt ttgctcaagg agaaattgaa     2220

gccatagtcg tgcctgtttg cttagcgttc ctattgacaa ctcttctggg agtgctgttc     2280

tgctttaata agcgagacct aattaaaaaa cacatctggc ctaatgttcc agatccttca     2340

aagagtcata ttgcccagtg gtcacctcac actcctccaa ggcacaactt tagttcaaaa     2400

gatcaaatgt attcagatgg caatttcact gatgtaagtg ttgtggaaat agaagcaaat     2460

gacaaaaaac cttttccaga agatctgaaa tcattggacc tgttcaaaaa ggaaaaaatt     2520

aatactgaag gacacagcag tggtattggg ggttcttcat gcatgtcatc ttctaggcca     2580

agcatttcta gcagtgatga aaatgaatct tcacaaaaca cttcgagcac tgtccagtat     2640

tctactgtgg tgcacagtgg ctacagacac caagttccat ccgtgcaagt cttctcaaga     2700

tccgagtcta cccagccctt gttagattca gaggagcggc cagaagatct acaattagta     2760

gatcatgtag atggcagtga tgacattttg cccaggcaac agtatttcaa acagaactgc     2820

agtcagcatg aatccagtcc cgatatttca cattttgaaa ggtcaaagca agtttcatca     2880

gtcaatgagg aagattttgt tagacttaaa caacagattt cagatcatat ttcacaatcc     2940

tgtggatctg gggaaatgaa aatgtttcag gaagtttctg cagcagatcc ttttggtcca     3000

ggtactgagg gacaaataga aagatttgaa acaattggga tggaggctgc cattgatgaa     3060

ggaatgccta aaagttactt accacagact gtacggcaag gtggctacat gcctcagtga     3120

aggactagta gttcctgctg caacttcagc agtacctata aagtaaagct aaaattattt     3180

tatctgtgaa ttcagatttc aaaaagtctt cactctctga agatgatcat ttgcccttaa     3240

ggacaaaaat gaactgaagt ttcacatgag ctatttccat tccagaatat ctgggattct     3300

actttaagca ctacataaac tgacttcatc ctcagactag ctgaatgatt ttgtgctgtt     3360

tcaggatgtt tgcactgaag aaaaatagaa agcttatctg aaatttataa aactttttgt     3420

tttgctacat aaaaaacaag gtatttaaat aataagcagt gatatgctta gtgagcacag     3480

ctatactgat tttgatgagt catcaaagtg gcttagggac agttaatata aaagattaga     3540

ggagcaaggt gtagaccatc tacttcagct aaaataactt aaaaagagat ccataggcca     3600

taactatatg agcccagctt ttgtaatctg ccaaaaaaaa atgagcagcc tcgtgtatat     3660

caatgtacac aatattcctt aggtcccttc cattggtagt gatgctgcca gttattactg     3720

gagaaaagga attctagagc tttaacttgg caggttaaaa gtactcattt tttattcatc     3780

aataattagt aatctcacta gttttcaaaa atttgcatat tattgacaac ctctttgaag     3840

aactatttca caaactcaac agagtgccat gataagagct agggatcccc caaactatct     3900

caagcatcta aaaaattgcc atttttaaag gcttaaattg tagtaataaa gggggaaaaa     3960

gtggtagtaa agaggaaaaa aaaaaacaaa gcatctaaaa aaatggcatt tttaaaggct     4020

taaattgctg atgtttatat atatatacac acacatatat acacacatat cattgacctt     4080

aagacttcag agaattgggt agatgaagca ctttatatag tatatatctt cagcttaaat     4140

ttgtttagag tactttttaa aatttttaag taggtaaaga tttaaaactt tttattttta     4200

gtgaatgttt gaagcaaact aagatgactt gggcaatatt taccaaaaca aaacagaacc     4260

ccaaaaaatg tacatcttga tcttagcaaa tatccttatt gtagagacag taaagagatg     4320

gtattttaat atctgcagtt ctgaggtagg gtggaactta gttctacatt gtgatttagg     4380

aatttttaaa accctttttc ttcaagggag aagtgaccca ggcctcaagt ttaatgctaa     4440

agccactagt gtacttatgc tgtcccctaa ccaccacttg gcattatgga gacagaggct     4500

aaatataggg gctttcttaa gaaagtaaga ggaaattagc aagcattatt agtgattgac     4560

tactgctatc aagtgaattc aaaggaaaca gatttttaat gccatattta agttacagaa     4620

accaggcatg cttagaatag tttctagagg ttattggaga atagaaagct aagaaaactt     4680

ggtatacatt tacaattgaa atataattac actttttact ctcagaatat tattcacatt     4740

aggcttcctg tttcttttat attcttgcat ttatataaca cctgatcctt tcaaagttct     4800

ttcacatatt atatgatcgt ctttatgaaa aaaaatgctt ttttctgata tattcagttt     4860

cccacttgag acaaaattag attaatagag tcactaattc aaagtagatg aggaaaatca     4920

ggcacagaga agtaaaggta gagatagacc caaatttaca caacaagata atgatattgc     4980

caccgtttaa gttggtcatc aaaggctggg ctggatttgt cttgctatat gtgtcaggaa     5040

atttatacct attacatttt ccattttctc aaaataagtc acatgactgt aatgtttagc     5100

tgcaacttat aacaaatagt gtcatgaaga atgttttagt gtgaggtttg tacatttcag     5160

agtcagttat acaatgtgaa ctcttgatct atgggaatga gaatggagga tcattgaagg     5220

ccatgataca aacaaatgta catgttaaag cctgtataaa acatggtaca gtgagtgaat     5280

acccccatcc ccaagaacac ttgatacata ttaaatgggt atatgattac tgtccagaaa     5340

tgcattccgg agatgaacat tcatttgagc actaatatat aatgtacatc ttctgcccta     5400

aggagaaaat aaattataaa acttgtttta cattcaaaat tactttcccg agcatgtctt     5460

agaataatct gtgtgttgat gcatgtaaat tgtactttag gtaggcaaag aaacaaattt     5520

ggttatttat gtaaaaacta atctaataaa gttagtgact ttatcacttt aaatctttag     5580

agtctaaaag tggtgtttaa agtaacacta gcacatcaga gaaccttgtc tggacaaaac     5640

tagttcactc actgcttctg caactgcagt tgctcccttc agggttatag aaaaaggacc     5700

caaatgttac atgtgttgat attataactt gtcagttact gatgtctgta gtatcctacc     5760

ctcacctctg aaagggataa tactgaataa ttattagaaa actataaaac ttcacacttt     5820

gtaccattaa gacctaaaat tttaatccta tcctttttta tgatggatca gtcagcactc     5880

gaacagcagc aaggaaaaaa agcaaatttc attcacatat tctgtgttca tctctcttct     5940

ctacctaatt gttcatttaa tttcagcctt gttccttgat aagggatttt accacatgaa     6000

gtcatccagt gtccctagct cttactgtga agttagtgga gtataattac aaatgttaca     6060

acttaaaaat gttacaaaac atttatcaaa gctcatattt agagtatcta gtttgagaaa     6120

tagaaatcaa ttattaaaga tgtctttttt ctacccaatt taactagtta aaaccatgac     6180

atgtaaatgt agaagtagaa taatcataca gaattcccta aaatgtttct gtttactaac     6240

attgagcaag tacatcaagt agagagatct tccttcattc tgttatagtc cacatcattc     6300

taattttgct cagttattat taagagcata ttcctaaacc atacactttt atttcaataa     6360

agttttattt tgttgagatg aataaaatat caaagttata agctacataa gacaaaagtt     6420

caattgttca aacaaattta ctgggatagc tttctattat agggattgtt agattatatt     6480

gctctggtaa gattactttc taaaaagttt gtacttttct gtaaaataaa agaatatgga     6540

atcataaaat ggcacgtgtt ttagggttag cctaaaattg ggcattgtca tcgatttcaa     6600

agaaggtatg aactagcagg cttacagcct aatctttgga ctggtccttg gcagcagttc     6660

cttttcagac tcaaacagaa ttcagataga tgtaagtcaa aacaaaactt cacaaagcca     6720

agcatattat cttttgcatt aacctatttc tccatcatac atgatactag tatgtgcatt     6780

agcatgatat tctcatatac attatattaa aaattaaaag gtggcagctc agggtgagct     6840

cttctgttat tcatttgttc ctaaattttt aagggctttt tctcagtcaa tagtttgtac     6900

aaactggtta gtttaacttc attatccatt tctttaaagt tgatggatcg tgataagatg     6960

catttaaggc caatagtgat agattttttt tatctcttga acacaagctt tgtctgaatg     7020

atactcttat ctcttaaaca caagctttga atgataacta caggttttaa gtgctgttac     7080

attaatacca taatgtgatg tgttagaaac aaagggatat ttcaaaggta ggtatttgaa     7140

aattctctag tctcaatgta tatgtgtatt gaatatactc taaaaataaa tgtgcaattt     7200

gctagtagga caatgcagtg attagcatta ggtatgtctc ttttatatcc tagctgtgtc     7260

ccactttctt ctaagtgcaa tcctttcatg ttcacttgct gttttattcc atctactctt     7320

aactgcattt ggaaggcttg tctagagtat agcatgtatt tttacctttg cagtgaattg     7380

catgtgctaa ttgtaaccac agctattttt atgttgacat aactccaaat gttatattaa     7440

atgttctatt acatatcagc tctaatccct taagtaaagt ttaagaaata aattcttgtt     7500

caaattgtt                                                             7509


<210>  31
<211>  7454
<212>  DNA
<213>  Rattus norvegicus

<400>  31
gagcatccct tgcaagatgt ccgcactaag gatctggcta atgcaagctt tgcttatttt       60

cctcactact gagtctatag gtcaacttgt ggaaccatgt ggttatatct accctgagtt      120

tccagttgtc cagcgtggct ctaacttcac tgccacttgt gtgctaaagg agaagtgtct      180

gcaggtgtac tccgtgaatg ccacttacat cgtgtggaag acaaaccatg ttgccgttcc      240

taaggagcag gtcacagtca tcaacagaac ggcatccagt gtcacattca cagacgtggt      300

ctttcagaac gtccagctca cctgcaatat cctgtcattt ggacagatcg agcagaatgt      360

gtatggaatc accatacttt caggctatcc tccagatata cctacaaatt tgagttgcat      420

tgtgaatgag gggaagaaca tgctgtgtca gtgggaccca ggaagggaga cataccttga      480

aacaaactac actttgaagt cagagtgggc aacagagaag tttcctgatt gtcgaacaaa      540

gcatggcacg agctcctgca tgatgggcta tacccccatc tattttgtca acatcgaggt      600

ctgggtggag gccgagaatg cccttgggaa tgtctcctca gagcctatca attttgaccc      660

cgtggataaa gtgaaaccca gcccacctca taatttgtca gtgaccaact cagaagaatt      720

atccagtata ttaaaactag catgggtcaa ttcaggtttg gacagtattt taaggctgaa      780

gtcggacatc caatatagga ccaaagatgc ctcaacttgg attcaggtcc ctcttgaaga      840

tacagtgtct ccccggactt cgttcactgt tcaggatctc aagcctttta cagaatatgt      900

gtttaggatt cggtccatta aggagaatgg gaagggctac tggagtgact ggagtgagga      960

ggcgagcggg accacatatg aagacagacc atccaaagcg ccaagtttct ggtataaggt     1020

aaatgcaaac catccacagg agtataggtc tgcacggctc atatggaaga cattgcccct     1080

ttctgaagcc aatgggaaga tcttggatta tgaagtggtt cttacacagt ccaagtcagt     1140

ttcgcaaact tacacagtta acggcacaga gttgatagta aacctcacca ataaccgcta     1200

tgtagcgtct ctagcagcaa gaaatgtggt cggcaagtcc cctgcaaccg tcctcaccat     1260

ccccggctcc cacttcaaag cttctcaccc cgtagtggat cttaaagcat ttccaaaaga     1320

taacctgctc tgggtagaat ggacaccgcc atctaaacct gtgaacaaat acatactaga     1380

gtggtgtgtg ttgtcagaga actcaccctg catcccagac tggcagcaag aagatggcac     1440

tgtgaatcgg acccacttaa gaggaagcct actggagagc aagtgctatc tgatcacagt     1500

aaccccagtg tttcccggtg ggcctggaag ccctgagtcc atgaaggcgt acctcaaaca     1560

agcagctcct tctaaaggac cgactgttcg gacaaagaaa gtggggaaaa atgaagctgt     1620

cttagagtgg gaccatcttc ctgttgatgt ccagaacgga ttcattagaa actactccat     1680

atcttataga accagtgttg gaaaagaaat ggttgtgcgt gtggattctt ctcacacaga     1740

atacacactg tcctctttga gtagcgatac actgtacatg gtccacatgg cagcatacac     1800

agaagaaggt gggaaggatg ggccggaatt cacttttaca acactaaagt ttgctcaagg     1860

agaaatcgaa gccatagtcg tgcctgtgtg cttagctttc ctcctgacaa cgctgctggg     1920

agtcttgttc tgctttaata aacgagacct aattaaaaaa cacatctggc cgaatgtccc     1980

agatccttca aagagtcata ttgcccagtg gtcacctcac acccccccaa ggcacaattt     2040

taactccaaa gatcagatgt actcagatgc caatttcact gacgtaagcg ttgtggaaat     2100

agaagcaaac aacaaaaagc cttgtccaga tgacctgaaa tccttggacc tgttcaagaa     2160

ggagaaaata agtacagaag ggcacagcag tggcattggg gggtcctcgt gcatgtcctc     2220

ttctaggccc agcatctcca gcagtgagga gaacgagtct gctcagagca ccgcaagcac     2280

ggtgcagtac tccaccgtgg tgcacagcgg ctacaggcac caggtgccgt cagtgcaagt     2340

gttctcaagg tctgagtcca cccagcccct gctagactcc gaggagcggc cagaggacct     2400

gcagctggtg gatagtgtgg acagcggtga cgagatctta cccaggcaac agtatttcaa     2460

acaaagctgc agtcagcctg gagccagtcc agatgtttca cacttcgaaa ggtcaagcca     2520

ggttccgtca ggcagtgagg aggattttgt cagactgaaa cagcagcagg tttcagatca     2580

catttcagag ccctatggct ccgagcaacg gaggctgttt caggaaggtt ctgtggcaga     2640

tgctcttggc acagggactg atggacagat agagagattc gaatctgttg gaatggagac     2700

agcgatggat gaagacattt ccaaaagtta cttgccacag actgtaagac aaggtggcta     2760

catgccacag tgagggaccg gctcctgcgg gacctcagcg ggactgcgaa gtaaagctaa     2820

aatgctcgtg acttcagatg ggaaataatc ttcagtccct gatgataacc attgccttta     2880

aggacaaagt cacaactggg ccatctccat tccagagtat ctgggattct ccttcaagca     2940

ctacatgaac tgactttatc ctctgaatag ctggaggact ctgcgctgtt tcagaatgtt     3000

tgcactgctg aaaactaagt gtgtctgagt ttgtaaagct tttgttttgc tccatagaaa     3060

gtggggaatt taaatgagcc gagccgagcc atggcgtcgc tcagctgtgc tggtggtgag     3120

actgaccatt cagatgccgg gagcaaaggt ctaaccctcc tcagccagca gcttcatgtc     3180

agagttcccc gggcagactg cccagattgt gtcacctatc aaaaaaaaaa aaaaaagagt     3240

ggagggggca gggtggctca tttctgggtt tgttattaga gaatcttggc ttgtttggtg     3300

ccgttggtat cgatgcttcc agttattact gaagaaaagg acgaactttc aagagaagca     3360

gcatagaaga acccattacc ttatattcac ctaaaacctc acagaaacct gcttattagt     3420

gataacattt ttcaaagtca gtttcaccaa cactctagtg gaccgggctg gcctcaaact     3480

cacagagatt tgtctgcctc agcctccgga gtactggggt taaaggcatg taccaccacc     3540

accacttgac ttaaaaattt gctgttttta aagacttaag ttgctgacat ttttctgaac     3600

gtatataaac acaccaggga cagatgattc cagatgttgg tggaggaagc actttatcca     3660

gaatgtcttc aactgtacat tactttaatt gactccacct tgtttttgtt tttaagacta     3720

gcaaggtgtt tgctgaaggg tggcattgcc cagaggctca ggcgagtccc agagctcacg     3780

caccgatgtc tgtgaccacc accgtggcag aagtcctcct acaaagctga cgaagccgtg     3840

agggttttgt tagtttgctg ggcggggatt gagcccacag ccttgtacat gctagacact     3900

accactgagc tcacctacac atctcactat gttatgtagg ctcaagcgat cctcctgtct     3960

cagcttcctg agtgttggga cttcgggtgt gcgctgccac acacccgacc aggtagtttt     4020

aatatctgcc atttatgagg tagagtttta cacaggattt aggactatct taaacctgtt     4080

ccttaggttg ctttgttaag gaatagcctg gacatccggt gtttagcact aaagccatta     4140

tgtatgcgcc taactttcca gtgacatgtc ctgggtgggc aggagttgac tgagcgccat     4200

tagtggttga ttaccaccaa gtgtgcgcac aggaaaagga ttaaagtttc agaacatggc     4260

ccttaatcat tcatagccgc tgccccacgg tggctgagga ggagttgatg tgcactgagc     4320

tggatgtggt tttgccgttc actcagagga ctgtttatac tctacttgtg atgtgttatc     4380

gttatatttt tatactaggt aatcctgttc tgagtccttt cacgtgtata atcctcatgg     4440

gactgtacgt gctttgctct ggtattcagt tgccttcttg gcaaaaccag cctagaattg     4500

ctaaaatgcc aggattgaag ttagatgatg aaagtcgggc acaggaaggc caggtcaggg     4560

tcagagagac cagaattcac actacaaggc tggcaccatc accattcaag ttgggcatgg     4620

aagcctgggc ccggcaggac tgagctccct atgtatgtgt atctgccagg aaattaacac     4680

ttgctaaatt tcccatcctc tcacagcgag cagtgtacct gtgcgctgct gtgaacgttg     4740

tagtgtgaag tctgtcctgg ggtagggagt taccagcgtg aggtcaggga tgaacacagc     4800

tcactgaaga cgagcctggt ggaagagagt ttgccattgt gcccactgca tgaacattcc     4860

ctcgggggat gtatcatgga gcacctctct ttgctctaag aaagagtctt agaattcatc     4920

ttaaatacag actttgctac agcatgttta agaataatct ggatgcacgt aacttgtatt     4980

ttaggtaggc agagaaacta atctggctgc tttctgtaaa accagtctaa taaagctaat     5040

tctatacatg ttcttttctt ctctcgtgtg taaaactgta gtttaaggca atcagaaaac     5100

aacctatctt gtggccaaaa ctagttcact gtagtttaag gcaatcagaa aacaacctat     5160

cttgtggcca aaactagttc actgcttctg atgcagttgc ctgcttagga gtcatagaca     5220

aagaaggttt aatgtaatca atattaccaa acagagttcc catcttttac tcaccaaaca     5280

aagtcagtcc ttcgaaaagc ataagtcagt actggcggac acagagaagc caaagtagga     5340

aaagtgcaac cccatcctgg ttctcctgtc tacagttcat tcagcttctg catagttcct     5400

gaactgtagg gttttttgct tttcgggttt tttttgtttt gttttggggt ttgtttgttt     5460

gttttgtttt tggggatttt gggggggtgt ttttggtttt ttaagatagg gtttctctgt     5520

gtggccttgg ctgtcctgga tctgccagcc tggtgtgcca ccactgtctg gtgagaccat     5580

agttcttact gtgaacttaa agggctgaag aggtagaagg gcttatggga cggactgcag     5640

cttctaattt tttctcaacc ctactttaat aatggttctt aaatgcttta accttccttc     5700

tagcccacca cccattaggg gtagtggaaa agagaggata caggtgaagt ggacctgttt     5760

agaaatggtt ctttggagca aatcctgtct gcactgtcag gaaatcagca gttcggttca     5820

ctggtcagca gtggcagccc cactcgagaa cacacttcct ggatgcacca gcagtccagt     5880

tcagtagtgt cgggagagca gcagcggtgg cccgacctag caggagtggc caggcctcag     5940

cctcagcaca agtcagcaga aagaaccaga agttctcagc tgtgcctctc agtgaaatga     6000

aaatatccaa gactgttgag tcctatatat actgcctcca aatatcatgt gtccgtgggt     6060

gtggtctccc cacgtgtctt gcctcagtat gtgagtctgt atcagctgac atgactgcca     6120

atcgacccag gtcaaggaat tcgcaagaag ccaccagaac acacgttttt tggtgtttct     6180

ctttatggag tcctgacaaa tggcgcacaa tgatacatgt gaggcaaacc aatatgtgtg     6240

ttattacaaa gaatccttca tcatgtgtcc tttcgaatgc tttctgtagc aaaatatcct     6300

ttcacctgtg tctgctttag caaaacaccg tccaacacaa ctgactttcc aaagaacctt     6360

aagtttccat tccacaggac actgtcaaag ccaggactgc taacgtccca ttagacatcg     6420

cactgttttt aaagctgtct tctttttcct gcccacagaa ttagagctac agcattcctc     6480

agtgtttgtc atagacatgt attaaccagg tagaacaagc caggaggttt tagactatta     6540

agtttactct cctgcttcat gttactgagt ttcctttaaa agcaagcttt taacacaact     6600

tctggttagt agagattttc atgacatgag tagaatcagt gagctgcaaa aaaaagtgta     6660

aaggtgaatt gttaaaaata accccttggg ctagctctgc tctaggcact gttgttacat     6720

tacccaggta agattacgtt ttaaaatgtg cctttctatg agttagaaaa cacactatat     6780

ggcaaactat ataattaatt catagacaaa gtcttctcaa gccagatgta ctatctctca     6840

ggttcatggt ttgttctgtc acatgcaggt tagcctatgc tcactccggt aaagctaaaa     6900

cggtgatggc tgtaggtgtt actcgctcta acttttttag ggctttttgt caccagtaag     6960

ctcccacaga ctggtcagtt ttttgtttgt tttttgtttg tttgttttaa ttagttgtca     7020

acaccagtga gggggtcagc atgaaaacgc accaggccgg ttgggtagag attcttagtc     7080

ctgtgatcac cagcttagtc tggtaaccac agactgcaaa tgctgttacg taactagaaa     7140

catgggacgt atcagaacaa ggggatgcta cacaggtgtt tgtgtaatat acagtgcacc     7200

ttgctgctag tgtgacagta ggcattccct gtggcccctt atgcctttgc tctcctgtac     7260

tccacgtgag ccctgttctc tcaactctgc cccacccacc catgcagctt cacatgggaa     7320

gcttgcccgt gttagcgctg tagtaagttg catgtgctga gtataaccaa agctatcatt     7380

tttatgttga ccctgtcata aatgtcttac tatatcagct ctaatccttt ttaaataaat     7440

ttgagaaaga aact                                                       7454


<210>  32
<211>  114
<212>  PRT
<213>  Antibody Sequence

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  33
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  33

Ser Tyr Gly Met His 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  34

Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  35

Gly Val Pro Asp Tyr 
1               5   


<210>  36
<211>  111
<212>  PRT
<213>  Antibody Sequence

<400>  36

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  37
<211>  14
<212>  PRT
<213>  Antibody Sequence

<400>  37

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  38
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  38

Ser Asn Asn Glu Arg Pro Ser 
1               5           


<210>  39
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  39

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  40
<211>  443
<212>  PRT
<213>  Antibody Sequence

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  41
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  41

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  42
<211>  116
<212>  PRT
<213>  Antibody Sequence

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Asp Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  43
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  43

Asp Tyr Tyr Met Ser 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  44

Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  45

Trp Asp Gly Pro Phe Asp Tyr 
1               5           


<210>  46
<211>  111
<212>  PRT
<213>  Antibody Sequence

<400>  46

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  47
<211>  14
<212>  PRT
<213>  Antibody Sequence

<400>  47

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  48
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  48

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  49
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  49

Gln Ser Tyr Asp Ser Ser Leu Gly Gly Ser Val 
1               5                   10      


<210>  50
<211>  440
<212>  PRT
<213>  Antibody Sequence

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Asp Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        355                 360                 365             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 


Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         


Ser Leu Ser His Ser Pro Gly Lys 
        435                 440 


<210>  51
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  51

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  52
<211>  438
<212>  PRT
<213>  Antibody Sequence

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
                165                 170                 175     


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu 
            180                 185                 190         


Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    210                 215                 220                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            260                 265                 270         


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        275                 280                 285             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                325                 330                 335     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            340                 345                 350         


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
        355                 360                 365             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    370                 375                 380                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
385                 390                 395                 400 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                405                 410                 415     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            420                 425                 430         


Ser His Ser Pro Gly Lys 
        435             


<210>  53
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  53

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  54
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met Asn Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  55
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  55

His Tyr Asp Met Asn 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  56

Val Ile Ser Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  57

Thr Pro Gly Ser His Phe Asp Tyr 
1               5               


<210>  58
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  58

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  59
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  59

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  60
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  60

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  61
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  61

Ser Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  62
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met Asn Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  63
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  63

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  64
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Asp Thr Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Trp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  65
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  65

Ile Tyr Ala Met Ser 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  66

Ser Ile Ser Asp Thr Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  67

Ser Asn Trp Gly Ser Leu Asp Tyr 
1               5               


<210>  68
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  68

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  69
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  69

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  70
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  70

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  71
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  71

Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 
1               5                   10      


<210>  72
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Asp Thr Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Trp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  73
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  73

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  74
<211>  479
<212>  PRT
<213>  Antibody Sequence

<400>  74

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
    130                 135                 140                 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
145                 150                 155                 160 


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
        195                 200                 205             


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
    210                 215                 220                 


Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 


<210>  75
<211>  481
<212>  PRT
<213>  Antibody Sequence

<400>  75

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met Asn Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Val Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210>  76
<211>  449
<212>  PRT
<213>  Antibody Sequence

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro His Asn Gly Gly Pro Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Leu Gly His Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  77
<211>  218
<212>  PRT
<213>  Antibody Sequence

<400>  77

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Glu Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  78
<211>  443
<212>  PRT
<213>  Antibody Sequence

<400>  78

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro His Asn Gly Gly Pro Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Leu Gly His Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
    210                 215                 220                 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
            260                 265                 270         


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
    290                 295                 300                 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
305                 310                 315                 320 


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
            340                 345                 350         


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
        355                 360                 365             


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
    370                 375                 380                 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
                405                 410                 415     


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440             


<210>  79
<211>  218
<212>  PRT
<213>  Antibody Sequence

<400>  79

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Glu Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  80
<211>  479
<212>  PRT
<213>  Antibody Sequence

<400>  80

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
    130                 135                 140                 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
145                 150                 155                 160 


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
        195                 200                 205             


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
    210                 215                 220                 


Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
        275                 280                 285             


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
    290                 295                 300                 


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
                325                 330                 335     


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
    370                 375                 380                 


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Trp Cys Met 
385                 390                 395                 400 


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
                405                 410                 415     


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
            420                 425                 430         


Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
        435                 440                 445             


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475                 


<210>  81
<211>  481
<212>  PRT
<213>  Antibody Sequence

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met Asn Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            260                 265                 270         


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
        275                 280                 285             


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
305                 310                 315                 320 


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
                325                 330                 335     


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
    370                 375                 380                 


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Ser 
385                 390                 395                 400 


Cys Ala Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
                405                 410                 415     


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
            420                 425                 430         


Asp Thr Asp Gly Ser Tyr Phe Val Val Ser Lys Leu Asn Val Gln Lys 
        435                 440                 445             


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
    450                 455                 460                 


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  82
<211>  114
<212>  PRT
<213>  Antibody Sequence

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  83
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  83

Ser Tyr Gly Met His 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  84

Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  85

Gly Val Pro Asp Tyr 
1               5   


<210>  86
<211>  111
<212>  PRT
<213>  Antibody Sequence

<400>  86

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  87
<211>  14
<212>  PRT
<213>  Antibody Sequence

<400>  87

Ser Gly Ser Ser Ser Asn Ile Gly Ser Gly Tyr Asp Val His 
1               5                   10                  


<210>  88
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  88

Ser Asn Asn Glu Arg Pro Ser 
1               5           


<210>  89
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  89

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  90
<211>  444
<212>  PRT
<213>  Antibody Sequence

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  91
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  91

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  92
<211>  444
<212>  PRT
<213>  Antibody Sequence

<400>  92

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  93
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  93

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Glu Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  94
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  94

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr His Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  95
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  95

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  96
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Ser Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  97
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  97

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  98
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  98

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  99
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  99

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  100
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  100

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  101
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  101

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  102
<211>  441
<212>  PRT
<213>  Antibody Sequence

<400>  102

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  103
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  103

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr 
145                 150                 155                 160 


Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His 
            180                 185                 190         


Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215     


<210>  104
<211>  438
<212>  PRT
<213>  Antibody Sequence

<400>  104

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
                165                 170                 175     


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu 
            180                 185                 190         


Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
    210                 215                 220                 


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
            260                 265                 270         


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
        275                 280                 285             


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
                325                 330                 335     


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
            340                 345                 350         


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
        355                 360                 365             


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
    370                 375                 380                 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
385                 390                 395                 400 


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
                405                 410                 415     


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
            420                 425                 430         


Ser His Ser Pro Gly Lys 
        435             


<210>  105
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  105

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Glu Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val 
145                 150                 155                 160 


Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg 
            180                 185                 190         


His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu 
        195                 200                 205             


Lys Ser Leu Ser Arg Ala Asp Cys Ser 
    210                 215         


<210>  106
<211>  114
<212>  PRT
<213>  Antibody Sequence

<400>  106

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  107
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  107

Ser Tyr Gly Met His 
1               5   


<210>  108
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  108

Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  109

Gly Val Pro Asp Tyr 
1               5   


<210>  110
<211>  111
<212>  PRT
<213>  Antibody Sequence

<400>  110

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Glu Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  111
<211>  14
<212>  PRT
<213>  Antibody Sequence

<400>  111

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp Tyr Asp Val His 
1               5                   10                  


<210>  112
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  112

Ser Asn Glu Glu Arg Pro Ser 
1               5           


<210>  113
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  113

Ser Ala Trp Asp Ser Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  114
<211>  342
<212>  DNA
<213>  Antibody Sequence

<400>  114
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccgtg atcagctacg acggcagcta caagtactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc tgctggcgtg      300

ccagattact ggggccaggg aacactggtc acagtgtcat ca                         342


<210>  115
<211>  333
<212>  DNA
<213>  Antibody Sequence

<400>  115
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcgactatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacagcaacg aggaacggcc tagcggcgtg      180

cccgatagat tttctggcag caagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactactgc agcgcctggg attcttctct gtctggccct      300

gtttttggcg gaggcaccaa gctgacagtg cta                                   333


<210>  116
<211>  443
<212>  PRT
<213>  Antibody Sequence

<400>  116

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  117
<211>  217
<212>  PRT
<213>  Antibody Sequence

<400>  117

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Glu Glu Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  118
<211>  481
<212>  PRT
<213>  Antibody Sequence

<400>  118

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr His Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Ser Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            260                 265                 270         


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
        275                 280                 285             


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
305                 310                 315                 320 


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
                325                 330                 335     


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
    370                 375                 380                 


Ile Pro Pro Cys Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Trp 
385                 390                 395                 400 


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
                405                 410                 415     


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
            420                 425                 430         


Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
        435                 440                 445             


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
    450                 455                 460                 


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  119
<211>  479
<212>  PRT
<213>  Antibody Sequence

<400>  119

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
    130                 135                 140                 


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser 
145                 150                 155                 160 


Asp Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ser Asn Glu Glu Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
        195                 200                 205             


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser 
    210                 215                 220                 


Ser Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            260                 265                 270         


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
        275                 280                 285             


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
    290                 295                 300                 


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
305                 310                 315                 320 


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
                325                 330                 335     


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
            340                 345                 350         


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Cys Thr Ile Pro 
    370                 375                 380                 


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Ser Cys Ala 
385                 390                 395                 400 


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
                405                 410                 415     


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
            420                 425                 430         


Asp Gly Ser Tyr Phe Val Val Ser Lys Leu Asn Val Gln Lys Ser Asn 
        435                 440                 445             


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
    450                 455                 460                 


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
465                 470                 475                 


<210>  120
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr His Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  121
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  121

His Tyr Asp Met His 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  122

Val Ile Ser Tyr His Gly Ser Val Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  123

Thr Pro Gly Phe His Phe Asp Tyr 
1               5               


<210>  124
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  124

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  125
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  125

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 
1               5                   10              


<210>  126
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  126

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  127
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  127

Ser Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  128
<211>  351
<212>  DNA
<213>  Antibody Sequence

<400>  128
caggttcagc tggtggaatc tggtggcgga gttgtgcagc ctggcagaag cctgagactg       60

tcttgtgccg ccagcggctt caccttcagc cactacgata tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccgtg atcagctacc acggcagcgt gaagttctac      180

gccgactccg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacaccc      300

ggcttccact tcgactattg gggccaggga accctggtca cagtctcttc a               351


<210>  129
<211>  330
<212>  DNA
<213>  Antibody Sequence

<400>  129
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatctc tggactgaga      240

agcgaggacg aggccgacta ctactgtagc gcctgggatg atagcctgtc cggcgttgtg      300

tttggcggag gcacaaagct gacagtgcta                                       330


<210>  130
<211>  446
<212>  PRT
<213>  Antibody Sequence

<400>  130

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr His Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  131
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  131

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  132
<211>  481
<212>  PRT
<213>  Antibody Sequence

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr His Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Ser Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  133
<211>  479
<212>  PRT
<213>  Antibody Sequence

<400>  133

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
    130                 135                 140                 


Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser 
145                 150                 155                 160 


Asp Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ser Asn Glu Glu Arg Pro Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
        195                 200                 205             


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser 
    210                 215                 220                 


Ser Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  134
<211>  1443
<212>  DNA
<213>  Antibody Sequence

<400>  134
caggtgcagc tggtggaatc tggtggcgga gttgtgcagc ctggcagatc cctgagactg       60

tcttgtgccg cctccggctt caccttcagc cactacgata tgcactgggt ccgacaggcc      120

cctggcaaag gattggaatg ggtcgccgtg atctcctacc acggctccgt gaagttctac      180

gccgacagcg tgaagggcag attcaccatc tctcgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc tagaacccct      300

ggcttccact tcgactattg gggccagggc acactggtca cagtttctag cggaggcgga      360

ggaagtggcg gcggaggatc tggcggtggt ggttctcagt ctgtgctgac ccaacctcct      420

tccgcttctg gcacacctgg ccagagagtg accatctctt gctccggctc ctcctccaac      480

atcggctcca attacgtgtc ctggtatcag cagctgcccg gcacagctcc caaactgctg      540

atctactacg acgacctgcg gccttctggc gtgcccgata gattctccgg ctctaagtct      600

ggcacctctg ccagcctggc tatctccgga ctgagatctg aggacgaggc cgactactac      660

tgctctgcct gggacgattc tctgtccggc gttgtgtttg gcggaggcac caaactgaca      720

gtgctcggag gtggtggctc tggtggcgga ggaagtggcg gaggcggttc tggtgttgaa      780

tgtcctccat gtcctgctcc tccagtggct ggcccttccg tgtttctgtt ccctccaaag      840

cctaaggaca ccctgatgat ctctcggacc cctgaagtga cctgtgtggt cgtgggagtg      900

tctcacgagg atcccgaagt gaagttcaat tggtacgtgg acggcgtgga agtgcacaac      960

gccaagacca agcctagaga ggaacagtac aactccacct acagagtggt gtccgtgctg     1020

accgtgctgc accaggattg gctgaacggc aaagagtaca agtgcaaggt gtccaacaag     1080

cagctgccct ctccaatcga aaagaccatc tccaaggcca agggacagcc cagagaaccc     1140

caggtgtaca cactgcctcc atgcagagat gagctgacca agaaccaggt gtccctgtgg     1200

tgtctggtca agggcttcta cccctccgat atcgccgtgg aatgggagtc taatggccag     1260

cctgagaaca actacaagac cacacctcct gtgctggact ccgacggctc attcttcctg     1320

tactccaagc tgacagtgga caagtccaga tggcagcagg gcaacgtgtt ctcctgctcc     1380

gtgatgcacg aggccctgca caatcactac acccagaagt ccctgtctct gtcccctggc     1440

aag                                                                   1443


<210>  135
<211>  1437
<212>  DNA
<213>  Antibody Sequence

<400>  135
gaagtgcagc tgctggaatc tggcggagga ttggttcagc ctggcggctc tctgagactg       60

tcttgtgccg cttccggctt caccttctcc agctacggaa tgcactgggt ccgacaggcc      120

cctggcaaag gattggaatg ggtcgccgtg atctcctacg acggctccta caagtactac      180

gccgactccg tgaagggcag attcaccatc tctcgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc tgctggcgtg      300

ccagattact ggggccaggg aacactggtc acagtgtcta gcggcggagg tggaagcgga      360

ggcggaggtt ctggtggtgg tggatctcag tctgtgctga cccagcctcc ttctgcttct      420

ggcacacctg gccagagagt gaccatctct tgctccggct cctcctccaa catcggctct      480

gactacgacg tgcactggta tcagcagctc cctggcacag ctcccaaact gctgatctac      540

tccaacgagg aacggcctag cggcgtgccc gatagattct ccggatctaa gtccggcacc      600

tctgccagcc tggctatctc tggcctgaga tctgaggacg aggccgacta ctactgctcc      660

gcctgggact cttctctgtc tggccctgtt tttggcggag gcaccaagct gacagtgctc      720

ggaggtggtg gctctggtgg cggaggaagt ggcggaggcg gttctggtgt tgaatgtcct      780

ccatgtcctg ctcctccagt ggctggccct tccgtgtttc tgttccctcc aaagcctaag      840

gacaccctga tgatctctcg gacccctgaa gtgacctgtg tggtcgtggg agtgtctcac      900

gaggatcccg aagtgaagtt caattggtac gtggacggcg tggaagtgca caacgccaag      960

accaagccta gagaggaaca gtacaactcc acctacagag tggtgtccgt gctgaccgtg     1020

ctgcaccagg attggctgaa cggcaaagag tacaagtgca aggtgtccaa caagcagctg     1080

ccctctccaa tcgaaaagac catctccaag gccaagggac agccccggga acctcaagtc     1140

tgtaccttgc ctcctagccg ggacgagctg accaagaatc aggtgtccct gtcctgtgcc     1200

gtgaagggct tctacccttc cgatatcgcc gtggaatggg agtccaatgg ccagcctgag     1260

aacaactaca agaccacacc tcctgtgctg gactccgacg gctcattctt cctggtgtcc     1320

aagctgacag tggacaagtc cagatggcag cagggcaacg tgttctcctg ctccgtgatg     1380

cacgaggccc tgcacaatca ctacacccag aagtccctga gcctgtctcc tggcaag        1437


<210>  136
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  136

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Ser Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  137
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  137

His Tyr Asp Met His 
1               5   


<210>  138
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  138

Val Ile Ser Tyr Ser Gly Ser Val Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  139

Thr Pro Gly Ser His Phe Asp Tyr 
1               5               


<210>  140
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  140

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  141
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  141

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  142
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  142

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  143
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  143

Ser Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  144
<211>  351
<212>  DNA
<213>  Antibody Sequence

<400>  144
caggttcagc tggtggaatc tggtggcgga gttgtgcagc ctggcagaag cctgagactg       60

tcttgtgccg ccagcggctt caccttcagc cactacgata tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccgtg atcagctaca gcggcagcgt gaagttctac      180

gccgactccg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacacct      300

ggcagccact tcgactattg gggccaggga acactggtca ccgttagctc a               351


<210>  145
<211>  330
<212>  DNA
<213>  Antibody Sequence

<400>  145
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgaactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatctc tggactgaga      240

agcgaggacg aggccgacta ctactgtagc gcctgggatg atagcctgtc cggcgttgtg      300

tttggcggag gcacaaagct gacagtgcta                                       330


<210>  146
<211>  446
<212>  PRT
<213>  Antibody Sequence

<400>  146

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Ser Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  147
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  147

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  148
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  148

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  149
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  149

His Tyr Asp Met His 
1               5   


<210>  150
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  150

Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  151
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  151

Thr Pro Gly Phe His Phe Asp Tyr 
1               5               


<210>  152
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  152

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  153
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  153

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 
1               5                   10              


<210>  154
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  154

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  155
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  155

Ser Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  156
<211>  351
<212>  DNA
<213>  Antibody Sequence

<400>  156
caggttcagc tggtggaatc tggtggcgga gttgtgcagc ctggcagaag cctgagactg       60

tcttgtgccg ccagcggctt caccttcagc cactacgata tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccgtg atcagctacg agggcagcaa caagttctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacaccc      300

ggcttccact tcgactattg gggccaggga accctggtca cagtctcttc a               351


<210>  157
<211>  330
<212>  DNA
<213>  Antibody Sequence

<400>  157
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatctc tggactgaga      240

agcgaggacg aggccgacta ctactgtagc gcctgggatg atagcctgtc cggcgttgtg      300

tttggcggag gcacaaagct gacagtgcta                                       330


<210>  158
<211>  446
<212>  PRT
<213>  Antibody Sequence

<400>  158

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  159
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  159

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  160
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  160

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  161
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  161

His Tyr Asp Met His 
1               5   


<210>  162
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  162

Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  163
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  163

Thr Pro Gly Phe His Phe Asp Tyr 
1               5               


<210>  164
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  164

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  165
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  165

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  166
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  166

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  167
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  167

Ser Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  168
<211>  351
<212>  DNA
<213>  Antibody Sequence

<400>  168
caggttcagc tggtggaatc tggtggcgga gttgtgcagc ctggcagaag cctgagactg       60

tcttgtgccg ccagcggctt caccttcagc cactacgata tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccgtg atcagctacg agggcagcaa caagttctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacaccc      300

ggcttccact tcgactattg gggccaggga accctggtca cagtctcttc a               351


<210>  169
<211>  330
<212>  DNA
<213>  Antibody Sequence

<400>  169
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgaactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatctc tggactgaga      240

agcgaggacg aggccgacta ctactgtagc gcctgggatg atagcctgtc cggcgttgtg      300

tttggcggag gcacaaagct gacagtgcta                                       330


<210>  170
<211>  446
<212>  PRT
<213>  Antibody Sequence

<400>  170

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  171
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  171

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  172
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  172

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  173
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  173

His Tyr Asp Met His 
1               5   


<210>  174
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  174

Val Ile Ser Tyr Glu Gly Ser Val Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  175

Thr Pro Gly Phe His Phe Asp Tyr 
1               5               


<210>  176
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  176

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  177
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  177

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  178
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  178

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  179
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  179

Ser Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  180
<211>  351
<212>  DNA
<213>  Antibody Sequence

<400>  180
caggttcagc tggtggaatc tggtggcgga gttgtgcagc ctggcagaag cctgagactg       60

tcttgtgccg ccagcggctt caccttcagc cactacgata tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtcgccgtg atcagctacg agggcagcgt gaagttctac      180

gccgactccg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaacaccc      300

ggcttccact tcgactattg gggccaggga accctggtca cagtctcttc a               351


<210>  181
<211>  330
<212>  DNA
<213>  Antibody Sequence

<400>  181
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaactacg tgaactggta tcagcagctg      120

cccggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatctc tggactgaga      240

agcgaggacg aggccgacta ctactgtagc gcctgggatg atagcctgtc cggcgttgtg      300

tttggcggag gcacaaagct gacagtgcta                                       330


<210>  182
<211>  446
<212>  PRT
<213>  Antibody Sequence

<400>  182

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  183
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  183

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  184
<211>  117
<212>  PRT
<213>  Antibody Sequence

<400>  184

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  185
<211>  5
<212>  PRT
<213>  Antibody Sequence

<400>  185

His Tyr Asp Met His 
1               5   


<210>  186
<211>  17
<212>  PRT
<213>  Antibody Sequence

<400>  186

Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  187
<211>  8
<212>  PRT
<213>  Antibody Sequence

<400>  187

Thr Pro Gly Ser His Phe Asp Tyr 
1               5               


<210>  188
<211>  110
<212>  PRT
<213>  Antibody Sequence

<400>  188

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  189
<211>  13
<212>  PRT
<213>  Antibody Sequence

<400>  189

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  190
<211>  7
<212>  PRT
<213>  Antibody Sequence

<400>  190

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  191
<211>  11
<212>  PRT
<213>  Antibody Sequence

<400>  191

Ser Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  192
<211>  444
<212>  PRT
<213>  Antibody Sequence

<400>  192

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  193
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  193

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  194
<211>  444
<212>  PRT
<213>  Antibody Sequence

<400>  194

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Asp Met Asn Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Ser Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Gly Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  195
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  195

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  196
<211>  444
<212>  PRT
<213>  Antibody Sequence

<400>  196

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Asp Thr Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Trp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  197
<211>  216
<212>  PRT
<213>  Antibody Sequence

<400>  197

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


