                         SEQUENCE LISTING

<110>  SPECIALITES PET FOOD
       INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, 
       L'ALIMENTATION ET L'ENVIRONNEMENT 
       UNIVERSITE DE BOURGOGNE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT NATIONAL SUPERIEUR DES SCIENCES AGRONOMIQUES, DE 
       L'ALIMENTATION ET DE L'ENVIRONNEMENT
 
<120>  NOVEL CANINE ODORANT BINDING PROTEINS

<130>  B380982PCT D40594 - LUL

<150>  EP 21305218.6
<151>  2021-02-23

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  174
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP1

<400>  1

Met Lys Thr Leu Leu Leu Thr Ile Gly Phe Ser Leu Ile Ala Ile Leu 
1               5                   10                  15      


Gln Ala Gln Asp Thr Pro Ala Leu Gly Lys Asp Thr Val Ala Val Ser 
            20                  25                  30          


Gly Lys Trp Tyr Leu Lys Ala Met Thr Ala Asp Gln Glu Val Pro Glu 
        35                  40                  45              


Lys Pro Asp Ser Val Thr Pro Met Ile Leu Lys Ala Gln Lys Gly Gly 
    50                  55                  60                  


Asn Leu Glu Ala Lys Ile Thr Met Leu Thr Asn Gly Gln Cys Gln Asn 
65                  70                  75                  80  


Ile Thr Val Val Leu His Lys Thr Ser Glu Pro Gly Lys Tyr Thr Ala 
                85                  90                  95      


Tyr Glu Gly Gln Arg Val Val Phe Ile Gln Pro Ser Pro Val Arg Asp 
            100                 105                 110         


His Tyr Ile Leu Tyr Cys Glu Gly Glu Leu His Gly Arg Gln Ile Arg 
        115                 120                 125             


Met Ala Lys Leu Leu Gly Arg Asp Pro Glu Gln Ser Gln Glu Ala Leu 
    130                 135                 140                 


Glu Asp Phe Arg Glu Phe Ser Arg Ala Lys Gly Leu Asn Gln Glu Ile 
145                 150                 155                 160 


Leu Glu Leu Ala Gln Ser Glu Thr Cys Ser Pro Gly Gly Gln 
                165                 170                 


<210>  2
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP2

<400>  2

Met Gln Leu Leu Leu Leu Thr Val Gly Leu Ala Leu Ile Cys Gly Leu 
1               5                   10                  15      


Gln Ala Gln Glu Gly Asn His Glu Glu Pro Gln Gly Gly Leu Glu Glu 
            20                  25                  30          


Leu Ser Gly Arg Trp His Ser Val Ala Leu Ala Ser Asn Lys Ser Asp 
        35                  40                  45              


Leu Ile Lys Pro Trp Gly His Phe Arg Val Phe Ile His Ser Met Ser 
    50                  55                  60                  


Ala Lys Asp Gly Asn Leu His Gly Asp Ile Leu Ile Pro Gln Asp Gly 
65                  70                  75                  80  


Gln Cys Glu Lys Val Ser Leu Thr Ala Phe Lys Thr Ala Thr Ser Asn 
                85                  90                  95      


Lys Phe Asp Leu Glu Tyr Trp Gly His Asn Asp Leu Tyr Leu Ala Glu 
            100                 105                 110         


Val Asp Pro Lys Ser Tyr Leu Ile Leu Tyr Met Ile Asn Gln Tyr Asn 
        115                 120                 125             


Asp Asp Thr Ser Leu Val Ala His Leu Met Val Arg Asp Leu Ser Arg 
    130                 135                 140                 


Gln Gln Asp Phe Leu Pro Ala Phe Glu Ser Val Cys Glu Asp Ile Gly 
145                 150                 155                 160 


Leu His Lys Asp Gln Ile Val Val Leu Ser Asp Asp Asp Arg Cys Gln 
                165                 170                 175     


Gly Ser Arg Asp 
            180 


<210>  3
<211>  190
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP3

<400>  3

Met Lys Leu Leu Leu Leu Cys Leu Gly Leu Ile Leu Val His Ala His 
1               5                   10                  15      


Glu Glu Glu Asn Asp Val Val Lys Gly Asn Phe Asp Ile Ser Lys Ile 
            20                  25                  30          


Ser Gly Asp Trp Tyr Ser Ile Leu Leu Ala Ser Asp Ile Lys Glu Lys 
        35                  40                  45              


Ile Glu Glu Asn Gly Ser Met Arg Val Phe Val Lys Asp Ile Glu Val 
    50                  55                  60                  


Leu Ser Asn Ser Ser Leu Ile Phe Thr Met His Thr Lys Val Asn Gly 
65                  70                  75                  80  


Lys Cys Thr Lys Ile Ser Leu Ile Cys Asn Lys Thr Glu Lys Asp Gly 
                85                  90                  95      


Glu Tyr Asp Val Val His Asp Gly Tyr Asn Leu Phe Arg Ile Ile Glu 
            100                 105                 110         


Thr Ala Tyr Glu Asp Tyr Ile Ile Phe His Leu Asn Asn Val Asn Gln 
        115                 120                 125             


Glu Gln Glu Phe Gln Leu Met Glu Leu Tyr Gly Arg Lys Pro Asp Val 
    130                 135                 140                 


Ser Pro Lys Val Lys Glu Lys Phe Val Arg Tyr Cys Gln Gly Met Glu 
145                 150                 155                 160 


Ile Pro Lys Glu Asn Ile Leu Asp Leu Thr Gln Val Asp Arg Cys Leu 
                165                 170                 175     


Gln Ala Arg Gln Ser Glu Ala Ala Gln Val Ser Ser Ala Glu 
            180                 185                 190 


<210>  4
<211>  184
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP4

<400>  4

Met Arg Cys Val Leu Leu Gly Gln Val Leu Val Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Ala Trp Ala Glu Val Leu Val Gln Pro Asp Phe Asp Ala Lys Lys 
            20                  25                  30          


Phe Ser Gly Leu Trp Tyr Val Val Ser Met Val Ser Asp Cys Lys Val 
        35                  40                  45              


Phe Leu Gly Lys Lys Asp His Leu Leu Met Ser Ser Arg Thr Ile Arg 
    50                  55                  60                  


Ala Met Pro Gly Gly Asn Leu Ser Val His Met Glu Phe Pro Arg Ala 
65                  70                  75                  80  


Asp Gly Cys His Gln Leu Asp Ala Glu Tyr Leu Arg Val Gly Ser Glu 
                85                  90                  95      


Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Val Ala 
            100                 105                 110         


Asp Thr Asp Tyr Asp Thr Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu 
        115                 120                 125             


Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Glu 
    130                 135                 140                 


Ala Ser Pro Gln Ala Thr Lys Ala Phe Gln Asp Phe Tyr Pro Thr Val 
145                 150                 155                 160 


Gly Leu Pro Asn Asp Met Met Val Met Leu Pro Lys Ser Asp Val Cys 
                165                 170                 175     


Ser Ser Ala Gly Lys Glu Ala Ser 
            180                 


<210>  5
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP1 Consensus sequence

<400>  5

Gln Asp Thr Pro Ala Leu Gly Lys Asp Thr Val Ala Val Ser Gly Lys 
1               5                   10                  15      


Trp Tyr Leu Lys Ala Met Thr Ala Asp Gln Glu Val Pro Glu Lys Pro 
            20                  25                  30          


Asp Ser Val Thr Pro Met Ile Leu Lys Ala Gln Lys Gly Gly Asn Leu 
        35                  40                  45              


Glu Ala Lys Ile Thr Met Leu Thr Asn Gly Gln Cys Gln Asn Ile Thr 
    50                  55                  60                  


Val Val Leu His Lys Thr Ser Glu Pro Gly Lys Tyr Thr Ala Tyr Glu 
65                  70                  75                  80  


Gly Gln Arg Val Val Phe Ile Gln Pro Ser Pro Val Arg Asp His Tyr 
                85                  90                  95      


Ile Leu Tyr Cys Glu Gly Glu Leu His Gly Arg Gln Ile Arg Met Ala 
            100                 105                 110         


Lys Leu Leu 
        115 


<210>  6
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP2 Consensus sequence

<400>  6

Gln Glu Gly Asn His Glu Glu Pro Gln Gly Gly Leu Glu Glu Leu Ser 
1               5                   10                  15      


Gly Arg Trp His Ser Val Ala Leu Ala Ser Asn Lys Ser Asp Leu Ile 
            20                  25                  30          


Lys Pro Trp Gly His Phe Arg Val Phe Ile His Ser Met Ser Ala Lys 
        35                  40                  45              


Asp Gly Asn Leu His Gly Asp Ile Leu Ile Pro Gln Asp Gly Gln Cys 
    50                  55                  60                  


Glu Lys Val Ser Leu Thr Ala Phe Lys Thr Ala Thr Ser Asn Lys Phe 
65                  70                  75                  80  


Asp Leu Glu Tyr Trp Gly His Asn Asp Leu Tyr Leu Ala Glu Val Asp 
                85                  90                  95      


Pro Lys Ser Tyr Leu Ile Leu Tyr Met Ile Asn Gln Tyr Asn Asp Asp 
            100                 105                 110         


Thr Ser Leu Val Ala His Leu Met Val 
        115                 120     


<210>  7
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP3 Consensus sequence

<400>  7

His Glu Glu Glu Asn Asp Val Val Lys Gly Asn Phe Asp Ile Ser Lys 
1               5                   10                  15      


Ile Ser Gly Asp Trp Tyr Ser Ile Leu Leu Ala Ser Asp Ile Lys Glu 
            20                  25                  30          


Lys Ile Glu Glu Asn Gly Ser Met Arg Val Phe Val Lys Asp Ile Glu 
        35                  40                  45              


Val Leu Ser Asn Ser Ser Leu Ile Phe Thr Met His Thr Lys Val Asn 
    50                  55                  60                  


Gly Lys Cys Thr Lys Ile Ser Leu Ile Cys Asn Lys Thr Glu Lys Asp 
65                  70                  75                  80  


Gly Glu Tyr Asp Val Val His Asp Gly Tyr Asn Leu Phe Arg Ile Ile 
                85                  90                  95      


Glu Thr Ala Tyr Glu Asp Tyr Ile Ile Phe His Leu Asn Asn Val Asn 
            100                 105                 110         


Gln Glu Gln Glu Phe Gln Leu Met Glu Leu Tyr Gly 
        115                 120                 


<210>  8
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP4 Consensus sequence

<400>  8

Glu Val Leu Val Gln Pro Asp Phe Asp Ala Lys Lys Phe Ser Gly Leu 
1               5                   10                  15      


Trp Tyr Val Val Ser Met Val Ser Asp Cys Lys Val Phe Leu Gly Lys 
            20                  25                  30          


Lys Asp His Leu Leu Met Ser Ser Arg Thr Ile Arg Ala Met Pro Gly 
        35                  40                  45              


Gly Asn Leu Ser Val His Met Glu Phe Pro Arg Ala Asp Gly Cys His 
    50                  55                  60                  


Gln Leu Asp Ala Glu Tyr Leu Arg Val Gly Ser Glu Gly His Phe Arg 
65                  70                  75                  80  


Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Val Ala Asp Thr Asp Tyr 
                85                  90                  95      


Asp Thr Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu Glu Gly Ala Leu 
            100                 105                 110         


Ser Thr Met Val Gln Leu Tyr Ser Arg 
        115                 120     


<210>  9
<211>  525
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP1 DNA seq >NM_001003190.1 Canis lupus familiaris odorant 
       binding protein 2B (OBP2B), mRNA

<400>  9
atgaagaccc tgctcctcac catcggcttc agcctcattg cgatcctgca ggcccaggat       60

accccagcct tgggaaagga cactgtggct gtgtcaggga aatggtatct gaaggccatg      120

acagcagacc aggaggtgcc tgagaagcct gactcagtga ctcccatgat cctcaaagcc      180

cagaaggggg gcaacctgga agccaagatc accatgctga caaatggtca gtgccagaac      240

atcacggtgg tcctgcacaa aacctctgag cctggcaaat acacggcata cgagggccag      300

cgtgtcgtgt tcatccagcc gtccccggtg agggaccact acattctcta ctgcgagggc      360

gagctccatg ggaggcagat ccgaatggcc aagcttctgg gaagggatcc tgagcagagc      420

caagaggcct tggaggattt tcgggaattc tcaagagcca aaggattgaa ccaggagatt      480

ttggaactcg cgcagagcga aacctgctct ccaggaggac agtag                      525


<210>  10
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP2 DNA seq >NM_001003189.2 Canis lupus familiaris minor 
       allergen Can f 2 (CANF2),mRNA

<400>  10
atgcagctcc tactgctgac cgtgggcctg gcactgatct gtggcctcca ggctcaggag       60

ggaaaccatg aggagcccca gggaggccta gaggagctgt ctgggaggtg gcactccgtt      120

gccctggcct ccaacaagtc cgatctgatc aaaccctggg ggcacttcag ggttttcatc      180

cacagcatga gcgcaaagga cggcaacctg cacggggata tccttatacc gcaggacggc      240

cagtgcgaga aagtctccct cactgcgttc aagactgcca ccagcaacaa atttgacctg      300

gagtactggg gacacaatga cctgtacctg gcagaggtag accccaagag ctacctgatt      360

ctctacatga tcaaccagta caacgatgac accagcctgg tggctcactt gatggtccgg      420

gacctcagca ggcagcagga cttcctgccg gcattcgaat ctgtatgtga agacatcggt      480

ctgcacaagg accagattgt ggttctgagc gatgacgatc gctgccaggg ttccagagac      540

tag                                                                    543


<210>  11
<211>  573
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP3 DNA seq >NM_001284461.1 Canis lupus familiaris allergen 
       Fel d 4-like (LOC481674), mRNA

<400>  11
atgaagctgc tgttgctgtg tctggggctg attctagtcc atgcccacga ggaagaaaac       60

gatgttgtga aaggaaactt cgatatttca aagatttcgg gagattggta ttccattctc      120

ttggcctcag atatcaagga aaagatagaa gaaaatggca gcatgagggt ttttgtgaaa      180

gacattgaag tcctgagcaa ctcttctctg atctttacaa tgcatacaaa ggtgaatggg      240

aagtgtacta aaatttctct gatttgtaac aaaacagaaa aggatggtga atatgatgtt      300

gtgcatgatg gatacaattt atttagaata attgaaacag cctatgagga ctatattata      360

tttcatctta ataatgtcaa ccaggaacag gaattccaac tgatggagct ctatggccga      420

aaaccagatg tgagtccaaa agtcaaggaa aagtttgtga gatattgcca aggaatggaa      480

attcctaagg aaaacatact tgacctgacc caagttgatc gctgtctcca ggcccgacag      540

agcgaagcag cccaggtctc cagtgctgag tga                                   573


<210>  12
<211>  555
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP4  DNA seq >XM_843825.5 PREDICTED: Canis lupus familiaris 
       lipocalin 15 (LCN15), transcript variant X3, mRNA

<400>  12
atgaggtgtg tcctgctggg ccaggtcctg gtgctgctct ggctgtccgg ggcttgggct       60

gaggtcctgg tacagccaga ttttgatgcc aaaaagttct caggtctttg gtacgtggtc      120

tccatggtct ccgactgcaa ggtcttcctg ggcaagaagg accacttgct catgtccagc      180

aggactatca gggccatgcc agggggcaac ctcagtgtcc acatggagtt ccctcgggct      240

gacggctgtc accagctgga tgctgagtac ctgagggtgg gctctgaggg gcacttcaga      300

gtcccagccc tgggctacct ggacgtgcgc gtggcagaca cagactatga caccttcgcc      360

gtgctctaca tctataagga gctggagggg gcgctcagca ccatggtcca gctctacagc      420

cggacccagg aagcaagtcc ccaagccaca aaggccttcc aggacttcta ccccaccgtg      480

gggctcccca atgacatgat ggtcatgctg cccaagtcag atgtgtgctc ctctgcaggc      540

aaggaggctt cctga                                                       555


<210>  13
<211>  174
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP1 variant Pro21Thr

<400>  13

Met Lys Thr Leu Leu Leu Thr Ile Gly Phe Ser Leu Ile Ala Ile Leu 
1               5                   10                  15      


Gln Ala Gln Asp Pro Pro Ala Leu Gly Lys Asp Thr Val Ala Val Ser 
            20                  25                  30          


Gly Lys Trp Tyr Leu Lys Ala Met Thr Ala Asp Gln Glu Val Pro Glu 
        35                  40                  45              


Lys Pro Asp Ser Val Thr Pro Met Ile Leu Lys Ala Gln Lys Gly Gly 
    50                  55                  60                  


Asn Leu Glu Ala Lys Ile Thr Met Leu Thr Asn Gly Gln Cys Gln Asn 
65                  70                  75                  80  


Ile Thr Val Val Leu His Lys Thr Ser Glu Pro Gly Lys Tyr Thr Ala 
                85                  90                  95      


Tyr Glu Gly Gln Arg Val Val Phe Ile Gln Pro Ser Pro Val Arg Asp 
            100                 105                 110         


His Tyr Ile Leu Tyr Cys Glu Gly Glu Leu His Gly Arg Gln Ile Arg 
        115                 120                 125             


Met Ala Lys Leu Leu Gly Arg Asp Pro Glu Gln Ser Gln Glu Ala Leu 
    130                 135                 140                 


Glu Asp Phe Arg Glu Phe Ser Arg Ala Lys Gly Leu Asn Gln Glu Ile 
145                 150                 155                 160 


Leu Glu Leu Ala Gln Ser Glu Thr Cys Ser Pro Gly Gly Gln 
                165                 170                 


<210>  14
<211>  174
<212>  PRT
<213>  Artificial

<220>
<223>   CfamOBP1 variant Ser52Leu

<400>  14

Met Lys Thr Leu Leu Leu Thr Ile Gly Phe Ser Leu Ile Ala Ile Leu 
1               5                   10                  15      


Gln Ala Gln Asp Thr Pro Ala Leu Gly Lys Asp Thr Val Ala Val Ser 
            20                  25                  30          


Gly Lys Trp Tyr Leu Lys Ala Met Thr Ala Asp Gln Glu Val Pro Glu 
        35                  40                  45              


Lys Pro Asp Leu Val Thr Pro Met Ile Leu Lys Ala Gln Lys Gly Gly 
    50                  55                  60                  


Asn Leu Glu Ala Lys Ile Thr Met Leu Thr Asn Gly Gln Cys Gln Asn 
65                  70                  75                  80  


Ile Thr Val Val Leu His Lys Thr Ser Glu Pro Gly Lys Tyr Thr Ala 
                85                  90                  95      


Tyr Glu Gly Gln Arg Val Val Phe Ile Gln Pro Ser Pro Val Arg Asp 
            100                 105                 110         


His Tyr Ile Leu Tyr Cys Glu Gly Glu Leu His Gly Arg Gln Ile Arg 
        115                 120                 125             


Met Ala Lys Leu Leu Gly Arg Asp Pro Glu Gln Ser Gln Glu Ala Leu 
    130                 135                 140                 


Glu Asp Phe Arg Glu Phe Ser Arg Ala Lys Gly Leu Asn Gln Glu Ile 
145                 150                 155                 160 


Leu Glu Leu Ala Gln Ser Glu Thr Cys Ser Pro Gly Gly Gln 
                165                 170                 


<210>  15
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP2 variant Glu83Lys

<400>  15

Met Gln Leu Leu Leu Leu Thr Val Gly Leu Ala Leu Ile Cys Gly Leu 
1               5                   10                  15      


Gln Ala Gln Glu Gly Asn His Glu Glu Pro Gln Gly Gly Leu Glu Glu 
            20                  25                  30          


Leu Ser Gly Arg Trp His Ser Val Ala Leu Ala Ser Asn Lys Ser Asp 
        35                  40                  45              


Leu Ile Lys Pro Trp Gly His Phe Arg Val Phe Ile His Ser Met Ser 
    50                  55                  60                  


Ala Lys Asp Gly Asn Leu His Gly Asp Ile Leu Ile Pro Gln Asp Gly 
65                  70                  75                  80  


Gln Cys Lys Lys Val Ser Leu Thr Ala Phe Lys Thr Ala Thr Ser Asn 
                85                  90                  95      


Lys Phe Asp Leu Glu Tyr Trp Gly His Asn Asp Leu Tyr Leu Ala Glu 
            100                 105                 110         


Val Asp Pro Lys Ser Tyr Leu Ile Leu Tyr Met Ile Asn Gln Tyr Asn 
        115                 120                 125             


Asp Asp Thr Ser Leu Val Ala His Leu Met Val Arg Asp Leu Ser Arg 
    130                 135                 140                 


Gln Gln Asp Phe Leu Pro Ala Phe Glu Ser Val Cys Glu Asp Ile Gly 
145                 150                 155                 160 


Leu His Lys Asp Gln Ile Val Val Leu Ser Asp Asp Asp Arg Cys Gln 
                165                 170                 175     


Gly Ser Arg Asp 
            180 


<210>  16
<211>  184
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP4 variant variant Ser140Gly

<400>  16

Met Arg Cys Val Leu Leu Gly Gln Val Leu Val Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Ala Trp Ala Glu Val Leu Val Gln Pro Asp Phe Asp Ala Lys Lys 
            20                  25                  30          


Phe Ser Gly Leu Trp Tyr Val Val Ser Met Val Ser Asp Cys Lys Val 
        35                  40                  45              


Phe Leu Gly Lys Lys Asp His Leu Leu Met Ser Ser Arg Thr Ile Arg 
    50                  55                  60                  


Ala Met Pro Gly Gly Asn Leu Ser Val His Met Glu Phe Pro Arg Ala 
65                  70                  75                  80  


Asp Gly Cys His Gln Leu Asp Ala Glu Tyr Leu Arg Val Gly Ser Glu 
                85                  90                  95      


Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Val Ala 
            100                 105                 110         


Asp Thr Asp Tyr Asp Thr Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu 
        115                 120                 125             


Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Gly Arg Thr Gln Glu 
    130                 135                 140                 


Ala Ser Pro Gln Ala Thr Lys Ala Phe Gln Asp Phe Tyr Pro Thr Val 
145                 150                 155                 160 


Gly Leu Pro Asn Asp Met Met Val Met Leu Pro Lys Ser Asp Val Cys 
                165                 170                 175     


Ser Ser Ala Gly Lys Glu Ala Ser 
            180                 


<210>  17
<211>  525
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP1 variant A61C

<400>  17
atgaagaccc tgctcctcac catcggcttc agcctcattg cgatcctgca ggcccaggat       60

cccccagcct tgggaaagga cactgtggct gtgtcaggga aatggtatct gaaggccatg      120

acagcagacc aggaggtgcc tgagaagcct gactcagtga ctcccatgat cctcaaagcc      180

cagaaggggg gcaacctgga agccaagatc accatgctga caaatggtca gtgccagaac      240

atcacggtgg tcctgcacaa aacctctgag cctggcaaat acacggcata cgagggccag      300

cgtgtcgtgt tcatccagcc gtccccggtg agggaccact acattctcta ctgcgagggc      360

gagctccatg ggaggcagat ccgaatggcc aagcttctgg gaagggatcc tgagcagagc      420

caagaggcct tggaggattt tcgggaattc tcaagagcca aaggattgaa ccaggagatt      480

ttggaactcg cgcagagcga aacctgctct ccaggaggac agtag                      525


<210>  18
<211>  525
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP1 variant C155T

<400>  18
atgaagaccc tgctcctcac catcggcttc agcctcattg cgatcctgca ggcccaggat       60

accccagcct tgggaaagga cactgtggct gtgtcaggga aatggtatct gaaggccatg      120

acagcagacc aggaggtgcc tgagaagcct gacttagtga ctcccatgat cctcaaagcc      180

cagaaggggg gcaacctgga agccaagatc accatgctga caaatggtca gtgccagaac      240

atcacggtgg tcctgcacaa aacctctgag cctggcaaat acacggcata cgagggccag      300

cgtgtcgtgt tcatccagcc gtccccggtg agggaccact acattctcta ctgcgagggc      360

gagctccatg ggaggcagat ccgaatggcc aagcttctgg gaagggatcc tgagcagagc      420

caagaggcct tggaggattt tcgggaattc tcaagagcca aaggattgaa ccaggagatt      480

ttggaactcg cgcagagcga aacctgctct ccaggaggac agtag                      525


<210>  19
<211>  525
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP1 variant G399A

<400>  19
atgaagaccc tgctcctcac catcggcttc agcctcattg cgatcctgca ggcccaggat       60

accccagcct tgggaaagga cactgtggct gtgtcaggga aatggtatct gaaggccatg      120

acagcagacc aggaggtgcc tgagaagcct gactcagtga ctcccatgat cctcaaagcc      180

cagaaggggg gcaacctgga agccaagatc accatgctga caaatggtca gtgccagaac      240

atcacggtgg tcctgcacaa aacctctgag cctggcaaat acacggcata cgagggccag      300

cgtgtcgtgt tcatccagcc gtccccggtg agggaccact acattctcta ctgcgagggc      360

gagctccatg ggaggcagat ccgaatggcc aagcttctag gaagggatcc tgagcagagc      420

caagaggcct tggaggattt tcgggaattc tcaagagcca aaggattgaa ccaggagatt      480

ttggaactcg cgcagagcga aacctgctct ccaggaggac agtag                      525


<210>  20
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP2 variant G51A

<400>  20
atgcagctcc tactgctgac cgtgggcctg gcactgatct gtggcctcca agctcaggag       60

ggaaaccatg aggagcccca gggaggccta gaggagctgt ctgggaggtg gcactccgtt      120

gccctggcct ccaacaagtc cgatctgatc aaaccctggg ggcacttcag ggttttcatc      180

cacagcatga gcgcaaagga cggcaacctg cacggggata tccttatacc gcaggacggc      240

cagtgcgaga aagtctccct cactgcgttc aagactgcca ccagcaacaa atttgacctg      300

gagtactggg gacacaatga cctgtacctg gcagaggtag accccaagag ctacctgatt      360

ctctacatga tcaaccagta caacgatgac accagcctgg tggctcactt gatggtccgg      420

gacctcagca ggcagcagga cttcctgccg gcattcgaat ctgtatgtga agacatcggt      480

ctgcacaagg accagattgt ggttctgagc gatgacgatc gctgccaggg ttccagagac      540

tag                                                                    543


<210>  21
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP2 variant T225C

<400>  21
atgcagctcc tactgctgac cgtgggcctg gcactgatct gtggcctcca ggctcaggag       60

ggaaaccatg aggagcccca gggaggccta gaggagctgt ctgggaggtg gcactccgtt      120

gccctggcct ccaacaagtc cgatctgatc aaaccctggg ggcacttcag ggttttcatc      180

cacagcatga gcgcaaagga cggcaacctg cacggggata tcctcatacc gcaggacggc      240

cagtgcgaga aagtctccct cactgcgttc aagactgcca ccagcaacaa atttgacctg      300

gagtactggg gacacaatga cctgtacctg gcagaggtag accccaagag ctacctgatt      360

ctctacatga tcaaccagta caacgatgac accagcctgg tggctcactt gatggtccgg      420

gacctcagca ggcagcagga cttcctgccg gcattcgaat ctgtatgtga agacatcggt      480

ctgcacaagg accagattgt ggttctgagc gatgacgatc gctgccaggg ttccagagac      540

tag                                                                    543


<210>  22
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP2 variant G247A

<400>  22
atgcagctcc tactgctgac cgtgggcctg gcactgatct gtggcctcca ggctcaggag       60

ggaaaccatg aggagcccca gggaggccta gaggagctgt ctgggaggtg gcactccgtt      120

gccctggcct ccaacaagtc cgatctgatc aaaccctggg ggcacttcag ggttttcatc      180

cacagcatga gcgcaaagga cggcaacctg cacggggata tccttatacc gcaggacggc      240

cagtgcaaga aagtctccct cactgcgttc aagactgcca ccagcaacaa atttgacctg      300

gagtactggg gacacaatga cctgtacctg gcagaggtag accccaagag ctacctgatt      360

ctctacatga tcaaccagta caacgatgac accagcctgg tggctcactt gatggtccgg      420

gacctcagca ggcagcagga cttcctgccg gcattcgaat ctgtatgtga agacatcggt      480

ctgcacaagg accagattgt ggttctgagc gatgacgatc gctgccaggg ttccagagac      540

tag                                                                    543


<210>  23
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  Cfam OBP2 variant T409C

<400>  23
atgcagctcc tactgctgac cgtgggcctg gcactgatct gtggcctcca ggctcaggag       60

ggaaaccatg aggagcccca gggaggccta gaggagctgt ctgggaggtg gcactccgtt      120

gccctggcct ccaacaagtc cgatctgatc aaaccctggg ggcacttcag ggttttcatc      180

cacagcatga gcgcaaagga cggcaacctg cacggggata tccttatacc gcaggacggc      240

cagtgcgaga aagtctccct cactgcgttc aagactgcca ccagcaacaa atttgacctg      300

gagtactggg gacacaatga cctgtacctg gcagaggtag accccaagag ctacctgatt      360

ctctacatga tcaaccagta caacgatgac accagcctgg tggctcacct gatggtccgg      420

gacctcagca ggcagcagga cttcctgccg gcattcgaat ctgtatgtga agacatcggt      480

ctgcacaagg accagattgt ggttctgagc gatgacgatc gctgccaggg ttccagagac      540

tag                                                                    543


<210>  24
<211>  543
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP2 variant T462C

<400>  24
atgcagctcc tactgctgac cgtgggcctg gcactgatct gtggcctcca ggctcaggag       60

ggaaaccatg aggagcccca gggaggccta gaggagctgt ctgggaggtg gcactccgtt      120

gccctggcct ccaacaagtc cgatctgatc aaaccctggg ggcacttcag ggttttcatc      180

cacagcatga gcgcaaagga cggcaacctg cacggggata tccttatacc gcaggacggc      240

cagtgcgaga aagtctccct cactgcgttc aagactgcca ccagcaacaa atttgacctg      300

gagtactggg gacacaatga cctgtacctg gcagaggtag accccaagag ctacctgatt      360

ctctacatga tcaaccagta caacgatgac accagcctgg tggctcactt gatggtccgg      420

gacctcagca ggcagcagga cttcctgccg gcattcgaat ccgtatgtga agacatcggt      480

ctgcacaagg accagattgt ggttctgagc gatgacgatc gctgccaggg ttccagagac      540

tag                                                                    543


<210>  25
<211>  573
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP3 variant G231A

<400>  25
atgaagctgc tgttgctgtg tctggggctg attctagtcc atgcccacga ggaagaaaac       60

gatgttgtga aaggaaactt cgatatttca aagatttcgg gagattggta ttccattctc      120

ttggcctcag atatcaagga aaagatagaa gaaaatggca gcatgagggt ttttgtgaaa      180

gacattgaag tcctgagcaa ctcttctctg atctttacaa tgcatacaaa agtgaatggg      240

aagtgtacta aaatttctct gatttgtaac aaaacagaaa aggatggtga atatgatgtt      300

gtgcatgatg gatacaattt atttagaata attgaaacag cctatgagga ctatattata      360

tttcatctta ataatgtcaa ccaggaacag gaattccaac tgatggagct ctatggccga      420

aaaccagatg tgagtccaaa agtcaaggaa aagtttgtga gatattgcca aggaatggaa      480

attcctaagg aaaacatact tgacctgacc caagttgatc gctgtctcca ggcccgacag      540

agcgaagcag cccaggtctc cagtgctgag tga                                   573


<210>  26
<211>  555
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP4 variant A418G

<400>  26
atgaggtgtg tcctgctggg ccaggtcctg gtgctgctct ggctgtccgg ggcttgggct       60

gaggtcctgg tacagccaga ttttgatgcc aaaaagttct caggtctttg gtacgtggtc      120

tccatggtct ccgactgcaa ggtcttcctg ggcaagaagg accacttgct catgtccagc      180

aggactatca gggccatgcc agggggcaac ctcagtgtcc acatggagtt ccctcgggct      240

gacggctgtc accagctgga tgctgagtac ctgagggtgg gctctgaggg gcacttcaga      300

gtcccagccc tgggctacct ggacgtgcgc gtggcagaca cagactatga caccttcgcc      360

gtgctctaca tctataagga gctggagggg gcgctcagca ccatggtcca gctctacggc      420

cggacccagg aagcaagtcc ccaagccaca aaggccttcc aggacttcta ccccaccgtg      480

gggctcccca atgacatgat ggtcatgctg cccaagtcag atgtgtgctc ctctgcaggc      540

aaggaggctt cctga                                                       555


<210>  27
<211>  190
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP3 variant Ile71Val

<400>  27

Met Lys Leu Leu Leu Leu Cys Leu Gly Leu Ile Leu Val His Ala His 
1               5                   10                  15      


Glu Glu Glu Asn Asp Val Val Lys Gly Asn Phe Asp Ile Ser Lys Ile 
            20                  25                  30          


Ser Gly Asp Trp Tyr Ser Ile Leu Leu Ala Ser Asp Ile Lys Glu Lys 
        35                  40                  45              


Ile Glu Glu Asn Gly Ser Met Arg Val Phe Val Lys Asp Ile Glu Val 
    50                  55                  60                  


Leu Ser Asn Ser Ser Leu Val Phe Thr Met His Thr Lys Val Asn Gly 
65                  70                  75                  80  


Lys Cys Thr Lys Ile Ser Leu Ile Cys Asn Lys Thr Glu Lys Asp Gly 
                85                  90                  95      


Glu Tyr Asp Val Val His Asp Gly Tyr Asn Leu Phe Arg Ile Ile Glu 
            100                 105                 110         


Thr Ala Tyr Glu Asp Tyr Ile Ile Phe His Leu Asn Asn Val Asn Gln 
        115                 120                 125             


Glu Gln Glu Phe Gln Leu Met Glu Leu Tyr Gly Arg Lys Pro Asp Val 
    130                 135                 140                 


Ser Pro Lys Val Lys Glu Lys Phe Val Arg Tyr Cys Gln Gly Met Glu 
145                 150                 155                 160 


Ile Pro Lys Glu Asn Ile Leu Asp Leu Thr Gln Val Asp Arg Cys Leu 
                165                 170                 175     


Gln Ala Arg Gln Ser Glu Ala Ala Gln Val Ser Ser Ala Glu 
            180                 185                 190 


<210>  28
<211>  184
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP4 variant Asn164Asp

<400>  28

Met Arg Cys Val Leu Leu Gly Gln Val Leu Val Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Ala Trp Ala Glu Val Leu Val Gln Pro Asp Phe Asp Ala Lys Lys 
            20                  25                  30          


Phe Ser Gly Leu Trp Tyr Val Val Ser Met Val Ser Asp Cys Lys Val 
        35                  40                  45              


Phe Leu Gly Lys Lys Asp His Leu Leu Met Ser Ser Arg Thr Ile Arg 
    50                  55                  60                  


Ala Met Pro Gly Gly Asn Leu Ser Val His Met Glu Phe Pro Arg Ala 
65                  70                  75                  80  


Asp Gly Cys His Gln Leu Asp Ala Glu Tyr Leu Arg Val Gly Ser Glu 
                85                  90                  95      


Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Val Ala 
            100                 105                 110         


Asp Thr Asp Tyr Asp Thr Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu 
        115                 120                 125             


Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Glu 
    130                 135                 140                 


Ala Ser Pro Gln Ala Thr Lys Ala Phe Gln Asp Phe Tyr Pro Thr Val 
145                 150                 155                 160 


Gly Leu Pro Asp Asp Met Met Val Met Leu Pro Lys Ser Asp Val Cys 
                165                 170                 175     


Ser Ser Ala Gly Lys Glu Ala Ser 
            180                 


<210>  29
<211>  525
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP1 variant G363A

<400>  29
atgaagaccc tgctcctcac catcggcttc agcctcattg cgatcctgca ggcccaggat       60

accccagcct tgggaaagga cactgtggct gtgtcaggga aatggtatct gaaggccatg      120

acagcagacc aggaggtgcc tgagaagcct gactcagtga ctcccatgat cctcaaagcc      180

cagaaggggg gcaacctgga agccaagatc accatgctga caaatggtca gtgccagaac      240

atcacggtgg tcctgcacaa aacctctgag cctggcaaat acacggcata cgagggccag      300

cgtgtcgtgt tcatccagcc gtccccggtg agggaccact acattctcta ctgcgagggc      360

gaactccatg ggaggcagat ccgaatggcc aagcttctgg gaagggatcc tgagcagagc      420

caagaggcct tggaggattt tcgggaattc tcaagagcca aaggattgaa ccaggagatt      480

ttggaactcg cgcagagcga aacctgctct ccaggaggac agtag                      525


<210>  30
<211>  573
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP3 variant G99A

<400>  30
atgaagctgc tgttgctgtg tctggggctg attctagtcc atgcccacga ggaagaaaac       60

gatgttgtga aaggaaactt cgatatttca aagatttcag gagattggta ttccattctc      120

ttggcctcag atatcaagga aaagatagaa gaaaatggca gcatgagggt ttttgtgaaa      180

gacattgaag tcctgagcaa ctcttctctg atctttacaa tgcatacaaa ggtgaatggg      240

aagtgtacta aaatttctct gatttgtaac aaaacagaaa aggatggtga atatgatgtt      300

gtgcatgatg gatacaattt atttagaata attgaaacag cctatgagga ctatattata      360

tttcatctta ataatgtcaa ccaggaacag gaattccaac tgatggagct ctatggccga      420

aaaccagatg tgagtccaaa agtcaaggaa aagtttgtga gatattgcca aggaatggaa      480

attcctaagg aaaacatact tgacctgacc caagttgatc gctgtctcca ggcccgacag      540

agcgaagcag cccaggtctc cagtgctgag tga                                   573


<210>  31
<211>  573
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP3 variant A211G

<400>  31
atgaagctgc tgttgctgtg tctggggctg attctagtcc atgcccacga ggaagaaaac       60

gatgttgtga aaggaaactt cgatatttca aagatttcgg gagattggta ttccattctc      120

ttggcctcag atatcaagga aaagatagaa gaaaatggca gcatgagggt ttttgtgaaa      180

gacattgaag tcctgagcaa ctcttctctg gtctttacaa tgcatacaaa ggtgaatggg      240

aagtgtacta aaatttctct gatttgtaac aaaacagaaa aggatggtga atatgatgtt      300

gtgcatgatg gatacaattt atttagaata attgaaacag cctatgagga ctatattata      360

tttcatctta ataatgtcaa ccaggaacag gaattccaac tgatggagct ctatggccga      420

aaaccagatg tgagtccaaa agtcaaggaa aagtttgtga gatattgcca aggaatggaa      480

attcctaagg aaaacatact tgacctgacc caagttgatc gctgtctcca ggcccgacag      540

agcgaagcag cccaggtctc cagtgctgag tga                                   573


<210>  32
<211>  555
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP4 variant C12T

<400>  32
atgaggtgtg ttctgctggg ccaggtcctg gtgctgctct ggctgtccgg ggcttgggct       60

gaggtcctgg tacagccaga ttttgatgcc aaaaagttct caggtctttg gtacgtggtc      120

tccatggtct ccgactgcaa ggtcttcctg ggcaagaagg accacttgct catgtccagc      180

aggactatca gggccatgcc agggggcaac ctcagtgtcc acatggagtt ccctcgggct      240

gacggctgtc accagctgga tgctgagtac ctgagggtgg gctctgaggg gcacttcaga      300

gtcccagccc tgggctacct ggacgtgcgc gtggcagaca cagactatga caccttcgcc      360

gtgctctaca tctataagga gctggagggg gcgctcagca ccatggtcca gctctacagc      420

cggacccagg aagcaagtcc ccaagccaca aaggccttcc aggacttcta ccccaccgtg      480

gggctcccca atgacatgat ggtcatgctg cccaagtcag atgtgtgctc ctctgcaggc      540

aaggaggctt cctga                                                       555


<210>  33
<211>  555
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP4 variant C177T

<400>  33
atgaggtgtg tcctgctggg ccaggtcctg gtgctgctct ggctgtccgg ggcttgggct       60

gaggtcctgg tacagccaga ttttgatgcc aaaaagttct caggtctttg gtacgtggtc      120

tccatggtct ccgactgcaa ggtcttcctg ggcaagaagg accacttgct catgtctagc      180

aggactatca gggccatgcc agggggcaac ctcagtgtcc acatggagtt ccctcgggct      240

gacggctgtc accagctgga tgctgagtac ctgagggtgg gctctgaggg gcacttcaga      300

gtcccagccc tgggctacct ggacgtgcgc gtggcagaca cagactatga caccttcgcc      360

gtgctctaca tctataagga gctggagggg gcgctcagca ccatggtcca gctctacagc      420

cggacccagg aagcaagtcc ccaagccaca aaggccttcc aggacttcta ccccaccgtg      480

gggctcccca atgacatgat ggtcatgctg cccaagtcag atgtgtgctc ctctgcaggc      540

aaggaggctt cctga                                                       555


<210>  34
<211>  555
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP4 variant A490G

<400>  34
atgaggtgtg tcctgctggg ccaggtcctg gtgctgctct ggctgtccgg ggcttgggct       60

gaggtcctgg tacagccaga ttttgatgcc aaaaagttct caggtctttg gtacgtggtc      120

tccatggtct ccgactgcaa ggtcttcctg ggcaagaagg accacttgct catgtccagc      180

aggactatca gggccatgcc agggggcaac ctcagtgtcc acatggagtt ccctcgggct      240

gacggctgtc accagctgga tgctgagtac ctgagggtgg gctctgaggg gcacttcaga      300

gtcccagccc tgggctacct ggacgtgcgc gtggcagaca cagactatga caccttcgcc      360

gtgctctaca tctataagga gctggagggg gcgctcagca ccatggtcca gctctacagc      420

cggacccagg aagcaagtcc ccaagccaca aaggccttcc aggacttcta ccccaccgtg      480

gggctccccg atgacatgat ggtcatgctg cccaagtcag atgtgtgctc ctctgcaggc      540

aaggaggctt cctga                                                       555


<210>  35
<211>  190
<212>  PRT
<213>  Artificial

<220>
<223>  CfamOBP3 mutant 102Y

<400>  35

Met Lys Leu Leu Leu Leu Cys Leu Gly Leu Ile Leu Val His Ala His 
1               5                   10                  15      


Glu Glu Glu Asn Asp Val Val Lys Gly Asn Phe Asp Ile Ser Lys Ile 
            20                  25                  30          


Ser Gly Asp Trp Tyr Ser Ile Leu Leu Ala Ser Asp Ile Lys Glu Lys 
        35                  40                  45              


Ile Glu Glu Asn Gly Ser Met Arg Val Phe Val Lys Asp Ile Glu Val 
    50                  55                  60                  


Leu Ser Asn Ser Ser Leu Ile Phe Thr Met His Thr Lys Val Asn Gly 
65                  70                  75                  80  


Lys Cys Thr Lys Ile Ser Leu Ile Cys Asn Lys Thr Glu Lys Asp Gly 
                85                  90                  95      


Glu Tyr Asp Val Val Tyr Asp Gly Tyr Asn Leu Phe Arg Ile Ile Glu 
            100                 105                 110         


Thr Ala Tyr Glu Asp Tyr Ile Ile Phe His Leu Asn Asn Val Asn Gln 
        115                 120                 125             


Glu Gln Glu Phe Gln Leu Met Glu Leu Tyr Gly Arg Lys Pro Asp Val 
    130                 135                 140                 


Ser Pro Lys Val Lys Glu Lys Phe Val Arg Tyr Cys Gln Gly Met Glu 
145                 150                 155                 160 


Ile Pro Lys Glu Asn Ile Leu Asp Leu Thr Gln Val Asp Arg Cys Leu 
                165                 170                 175     


Gln Ala Arg Gln Ser Glu Ala Ala Gln Val Ser Ser Ala Glu 
            180                 185                 190 


<210>  36
<211>  564
<212>  DNA
<213>  Artificial

<220>
<223>  CfamOBP3 mutant 102Y

<400>  36
atgagaggat ctcaccatca ccatcaccat acggatccgc atgaggagga aaacgacgtt       60

gtgaagggca acttcgacat cagcaagatc agcggcgatt ggtacagcat tctgctggcg      120

agcgacatca aggagaagat cgaggagaat ggcagcatgc gcgtgttcgt gaaggacatc      180

gaagtgctca gcaacagcag tctgatcttc acgatgcaca ccaaggtgaa cggcaaatgc      240

accaaaatca gcctcatttg caacaagacc gagaaggacg gcgagtacga tgtggtgtat      300

gatggttaca acctcttccg catcatcgag acggcctacg aagactacat catcttccat      360

ctcaacaacg tgaatcaaga acaagaattc cagctgatgg agctgtacgg ccgcaaaccg      420

gatgtgagcc caaaggtgaa ggagaagttc gtgcgctact gtcaaggcat ggagatcccg      480

aaagagaaca ttctggatct gacgcaagtt gaccgctgtc tgcaagcccg ccaaagcgaa      540

gccgcgcaag tgagcagcgc cgaa                                             564


