                         SEQUENCE LISTING

<110>  First Health Biopharmaceutical B.V.
 
<120>  ANTI-PROLIFERATIVE AGENTS

<130>  PCT 150765

<150>  EP21159563.2
<151>  2021-02-26

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Ser Arg Gly Asp 
            100                 105                 110         


Arg Ser Gly Phe Gly Lys Phe Glu Arg Gly Gly Asn Ser Arg Trp Cys 
        115                 120                 125             


Asp Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu 
    130                 135                 140                 


Arg Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro 
                165                 170                 175     


Pro His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met 
            180                 185                 190         


Gly Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys 
        195                 200                 205             


His Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala 
    210                 215                 220                 


Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser 
225                 230                 235                 240 


Gln Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu 
                245                 250                 255     


Asn Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu 
            260                 265                 270         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys 
        275                 280                 285             


Phe Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala 
    290                 295                 300                 


Asp Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu 
305                 310                 315                 320 


Val Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile 
                325                 330                 335     


Gly Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met 
            340                 345                 350         


Leu Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp 
        355                 360                 365             


Thr Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr 
    370                 375                 380                 


Phe Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr 
                405                 410                 415     


Gln Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu 
            420                 425                 430         


Asp Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val 
        435                 440                 445             


Glu Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu 
    450                 455                 460                 


Gly Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg 
465                 470                 475                 480 


Glu Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val 
                485                 490                 495     


Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His 
            500                 505                 510         


Val Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg 
        515                 520                 525             


Ile Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe 
    530                 535                 540                 


Phe Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu 
545                 550                 555                 560 


Val Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr 
                565                 570                 575     


Glu His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Ser Arg 
            580                 585                 590         


Phe Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ala 
        595                 600                 605             


Ser Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly 
    610                 615                 620                 


Gly Gly Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly 
625                 630                 635                 640 


Gly Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly 
                645                 650                 655     


Val Asp Trp Trp Gly Asn 
            660         


<210>  2
<211>  419
<212>  PRT
<213>  Drosophila melanogaster

<400>  2

Tyr Ile Pro Pro Glu Pro Ser Asn Asp Ala Ile Glu Ile Phe Ser Ser 
1               5                   10                  15      


Gly Ile Ala Ser Gly Ile His Phe Ser Lys Tyr Asn Asn Ile Pro Val 
            20                  25                  30          


Lys Val Thr Gly Ser Asp Val Pro Gln Pro Ile Gln His Phe Thr Ser 
        35                  40                  45              


Ala Asp Leu Arg Asp Ile Ile Ile Asp Asn Val Asn Lys Ser Gly Tyr 
    50                  55                  60                  


Lys Ile Pro Thr Pro Ile Gln Lys Cys Ser Ile Pro Val Ile Ser Ser 
65                  70                  75                  80  


Gly Arg Asp Leu Met Ala Cys Ala Gln Thr Gly Ser Gly Lys Thr Ala 
                85                  90                  95      


Ala Phe Leu Leu Pro Ile Leu Ser Lys Leu Leu Glu Asp Pro His Glu 
            100                 105                 110         


Leu Glu Leu Gly Arg Pro Gln Val Val Ile Val Ser Pro Thr Arg Glu 
        115                 120                 125             


Leu Ala Ile Gln Ile Phe Asn Glu Ala Arg Lys Phe Ala Phe Glu Ser 
    130                 135                 140                 


Tyr Leu Lys Ile Gly Ile Val Tyr Gly Gly Thr Ser Phe Arg His Gln 
145                 150                 155                 160 


Asn Glu Cys Ile Thr Arg Gly Cys His Val Val Ile Ala Thr Pro Gly 
                165                 170                 175     


Arg Leu Leu Asp Phe Val Asp Arg Thr Phe Ile Thr Phe Glu Asp Thr 
            180                 185                 190         


Arg Phe Val Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe 
        195                 200                 205             


Ser Glu Asp Met Arg Arg Ile Met Thr His Val Thr Met Arg Pro Glu 
    210                 215                 220                 


His Gln Thr Leu Met Phe Ser Ala Thr Phe Pro Glu Glu Ile Gln Arg 
225                 230                 235                 240 


Met Ala Gly Glu Phe Leu Lys Asn Tyr Val Phe Val Ala Ile Gly Ile 
                245                 250                 255     


Val Gly Gly Ala Cys Ser Asp Val Lys Gln Thr Ile Tyr Glu Val Asn 
            260                 265                 270         


Lys Tyr Ala Lys Arg Ser Lys Leu Ile Glu Ile Leu Ser Glu Gln Ala 
        275                 280                 285             


Asp Gly Thr Ile Val Phe Val Glu Thr Lys Arg Gly Ala Asp Phe Leu 
    290                 295                 300                 


Ala Ser Phe Leu Ser Glu Lys Glu Phe Pro Thr Thr Ser Ile His Gly 
305                 310                 315                 320 


Asp Arg Leu Gln Ser Gln Arg Glu Gln Ala Leu Arg Asp Phe Lys Asn 
                325                 330                 335     


Gly Ser Met Lys Val Leu Ile Ala Thr Ser Val Ala Ser Arg Gly Leu 
            340                 345                 350         


Asp Ile Lys Asn Ile Lys His Val Ile Asn Tyr Asp Met Pro Ser Lys 
        355                 360                 365             


Ile Asp Asp Tyr Val His Arg Ile Gly Arg Thr Gly Arg Val Gly Asn 
    370                 375                 380                 


Asn Gly Arg Ala Thr Ser Phe Phe Asp Pro Glu Lys Asp Arg Ala Ile 
385                 390                 395                 400 


Ala Ala Asp Leu Val Lys Ile Leu Glu Gly Ser Gly Gln Thr Val Pro 
                405                 410                 415     


Asp Phe Leu 
            


<210>  3
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asp Glu Asp Trp Glu Ala Glu Ile Asn Pro His Met Ser Ser 
1               5                   10                  15      


Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr Ser Gly Glu Asn Gly Asp 
            20                  25                  30          


Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser Glu Met Asp Asp Gly Pro 
        35                  40                  45              


Ser Arg Arg Asp His Phe Met Lys Ser Gly Phe Ala Ser Gly Arg Asn 
    50                  55                  60                  


Phe Gly Asn Arg Asp Ala Gly Glu Cys Asn Lys Arg Asp Asn Thr Ser 
65                  70                  75                  80  


Thr Met Gly Gly Phe Gly Val Gly Lys Ser Phe Gly Asn Arg Gly Phe 
                85                  90                  95      


Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser Ser Gly Phe Trp Arg Glu 
            100                 105                 110         


Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr Arg Asn Arg Gly Phe Ser 
        115                 120                 125             


Lys Arg Gly Gly Tyr Arg Asp Gly Asn Asn Ser Glu Ala Ser Gly Pro 
    130                 135                 140                 


Tyr Arg Arg Gly Gly Arg Gly Ser Phe Arg Gly Cys Arg Gly Gly Phe 
145                 150                 155                 160 


Gly Leu Gly Ser Pro Asn Asn Asp Leu Asp Pro Asp Glu Cys Met Gln 
                165                 170                 175     


Arg Thr Gly Gly Leu Phe Gly Ser Arg Arg Pro Val Leu Ser Gly Thr 
            180                 185                 190         


Gly Asn Gly Asp Thr Ser Gln Ser Arg Ser Gly Ser Gly Ser Glu Arg 
        195                 200                 205             


Gly Gly Tyr Lys Gly Leu Asn Glu Glu Val Ile Thr Gly Ser Gly Lys 
    210                 215                 220                 


Asn Ser Trp Lys Ser Glu Ala Glu Gly Gly Glu Ser Ser Asp Thr Gln 
225                 230                 235                 240 


Gly Pro Lys Val Thr Tyr Ile Pro Pro Pro Pro Pro Glu Asp Glu Asp 
                245                 250                 255     


Ser Ile Phe Ala His Tyr Gln Thr Gly Ile Asn Phe Asp Lys Tyr Asp 
            260                 265                 270         


Thr Ile Leu Val Glu Val Ser Gly His Asp Ala Pro Pro Ala Ile Leu 
        275                 280                 285             


Thr Phe Glu Glu Ala Asn Leu Cys Gln Thr Leu Asn Asn Asn Ile Ala 
    290                 295                 300                 


Lys Ala Gly Tyr Thr Lys Leu Thr Pro Val Gln Lys Tyr Ser Ile Pro 
305                 310                 315                 320 


Ile Ile Leu Ala Gly Arg Asp Leu Met Ala Cys Ala Gln Thr Gly Ser 
                325                 330                 335     


Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ala His Met Met His 
            340                 345                 350         


Asp Gly Ile Thr Ala Ser Arg Phe Lys Glu Leu Gln Glu Pro Glu Cys 
        355                 360                 365             


Ile Ile Val Ala Pro Thr Arg Glu Leu Val Asn Gln Ile Tyr Leu Glu 
    370                 375                 380                 


Ala Arg Lys Phe Ser Phe Gly Thr Cys Val Arg Ala Val Val Ile Tyr 
385                 390                 395                 400 


Gly Gly Thr Gln Leu Gly His Ser Ile Arg Gln Ile Val Gln Gly Cys 
                405                 410                 415     


Asn Ile Leu Cys Ala Thr Pro Gly Arg Leu Met Asp Ile Ile Gly Lys 
            420                 425                 430         


Glu Lys Ile Gly Leu Lys Gln Ile Lys Tyr Leu Val Leu Asp Glu Ala 
        435                 440                 445             


Asp Arg Met Leu Asp Met Gly Phe Gly Pro Glu Met Lys Lys Leu Ile 
    450                 455                 460                 


Ser Cys Pro Gly Met Pro Ser Lys Glu Gln Arg Gln Thr Leu Met Phe 
465                 470                 475                 480 


Ser Ala Thr Phe Pro Glu Glu Ile Gln Arg Leu Ala Ala Glu Phe Leu 
                485                 490                 495     


Lys Ser Asn Tyr Leu Phe Val Ala Val Gly Gln Val Gly Gly Ala Cys 
            500                 505                 510         


Arg Asp Val Gln Gln Thr Val Leu Gln Val Gly Gln Phe Ser Lys Arg 
        515                 520                 525             


Glu Lys Leu Val Glu Ile Leu Arg Asn Ile Gly Asp Glu Arg Thr Met 
    530                 535                 540                 


Val Phe Val Glu Thr Lys Lys Lys Ala Asp Phe Ile Ala Thr Phe Leu 
545                 550                 555                 560 


Cys Gln Glu Lys Ile Ser Thr Thr Ser Ile His Gly Asp Arg Glu Gln 
                565                 570                 575     


Arg Glu Arg Glu Gln Ala Leu Gly Asp Phe Arg Phe Gly Lys Cys Pro 
            580                 585                 590         


Val Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Ile Glu Asn 
        595                 600                 605             


Val Gln His Val Ile Asn Phe Asp Leu Pro Ser Thr Ile Asp Glu Tyr 
    610                 615                 620                 


Val His Arg Ile Gly Arg Thr Gly Arg Cys Gly Asn Thr Gly Arg Ala 
625                 630                 635                 640 


Ile Ser Phe Phe Asp Leu Glu Ser Asp Asn His Leu Ala Gln Pro Leu 
                645                 650                 655     


Val Lys Val Leu Thr Asp Ala Gln Gln Asp Val Pro Ala Trp Leu Glu 
            660                 665                 670         


Glu Ile Ala Phe Ser Thr Tyr Ile Pro Gly Phe Ser Gly Ser Thr Arg 
        675                 680                 685             


Gly Asn Val Phe Ala Ser Val Asp Thr Arg Lys Gly Lys Ser Thr Leu 
    690                 695                 700                 


Asn Thr Ala Gly Phe Ser Ser Ser Gln Ala Pro Asn Pro Val Asp Asp 
705                 710                 715                 720 


Glu Ser Trp Asp 
                


<210>  4
<211>  424
<212>  PRT
<213>  Drosophila melanogaster

<400>  4

Glu Phe Tyr Ile Pro Pro Glu Pro Ser Asn Asp Ala Ile Glu Ile Phe 
1               5                   10                  15      


Ser Ser Gly Ile Ala Ser Gly Ile His Phe Ser Lys Tyr Asn Asn Ile 
            20                  25                  30          


Pro Val Lys Val Thr Gly Ser Asp Val Pro Gln Pro Ile Gln His Phe 
        35                  40                  45              


Thr Ser Ala Asp Leu Arg Asp Ile Ile Ile Asp Asn Val Asn Lys Ser 
    50                  55                  60                  


Gly Tyr Lys Ile Pro Thr Pro Ile Gln Lys Cys Ser Ile Pro Val Ile 
65                  70                  75                  80  


Ser Ser Gly Arg Asp Leu Met Ala Cys Ala Gln Thr Gly Ser Gly Lys 
                85                  90                  95      


Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Lys Leu Leu Glu Asp Pro 
            100                 105                 110         


His Glu Leu Glu Leu Gly Arg Pro Gln Val Val Ile Val Ser Pro Thr 
        115                 120                 125             


Arg Glu Leu Ala Ile Gln Ile Phe Asn Glu Ala Arg Lys Phe Ala Phe 
    130                 135                 140                 


Glu Ser Tyr Leu Lys Ile Gly Ile Val Tyr Gly Gly Thr Ser Phe Arg 
145                 150                 155                 160 


His Gln Asn Glu Cys Ile Thr Arg Gly Cys His Val Val Ile Ala Thr 
                165                 170                 175     


Pro Gly Arg Leu Leu Asp Phe Val Asp Arg Thr Phe Ile Thr Phe Glu 
            180                 185                 190         


Asp Thr Arg Phe Val Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met 
        195                 200                 205             


Gly Phe Ser Glu Asp Met Arg Arg Ile Met Thr His Val Thr Met Arg 
    210                 215                 220                 


Pro Glu His Gln Thr Leu Met Phe Ser Ala Thr Phe Pro Glu Glu Ile 
225                 230                 235                 240 


Gln Arg Met Ala Gly Glu Phe Leu Lys Asn Tyr Val Phe Val Ala Ile 
                245                 250                 255     


Gly Ile Val Gly Gly Ala Cys Ser Asp Val Lys Gln Thr Ile Tyr Glu 
            260                 265                 270         


Val Asn Lys Tyr Ala Lys Arg Ser Lys Leu Ile Glu Ile Leu Ser Glu 
        275                 280                 285             


Gln Ala Asp Gly Thr Ile Val Phe Val Glu Thr Lys Arg Gly Ala Asp 
    290                 295                 300                 


Phe Leu Ala Ser Phe Leu Ser Glu Lys Glu Phe Pro Thr Thr Ser Ile 
305                 310                 315                 320 


His Gly Asp Arg Leu Gln Ser Gln Arg Glu Gln Ala Leu Arg Asp Phe 
                325                 330                 335     


Lys Asn Gly Ser Met Lys Val Leu Ile Ala Thr Ser Val Ala Ser Arg 
            340                 345                 350         


Gly Leu Asp Ile Lys Asn Ile Lys His Val Ile Asn Tyr Asp Met Pro 
        355                 360                 365             


Ser Lys Ile Asp Asp Tyr Val His Arg Ile Gly Arg Thr Gly Arg Val 
    370                 375                 380                 


Gly Asn Asn Gly Arg Ala Thr Ser Phe Phe Asp Pro Glu Lys Asp Arg 
385                 390                 395                 400 


Ala Ile Ala Ala Asp Leu Val Lys Ile Leu Glu Gly Ser Gly Gln Thr 
                405                 410                 415     


Val Pro Asp Phe Leu Arg Thr Cys 
            420                 


<210>  5
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Gly Tyr Ser Ser Asp Arg Asp Arg Gly Arg Asp Arg Gly Phe 
1               5                   10                  15      


Gly Ala Pro Arg Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys 
            20                  25                  30          


Lys Phe Gly Asn Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu 
        35                  40                  45              


Asp Glu Leu Pro Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp 
    50                  55                  60                  


Leu Ala Arg Arg Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys 
65                  70                  75                  80  


Glu Ile Thr Val Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe 
                85                  90                  95      


Tyr Glu Ala Asn Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln 
            100                 105                 110         


Asn Phe Thr Glu Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala 
        115                 120                 125             


Leu Ser Gly Leu Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys 
    130                 135                 140                 


Thr Leu Ser Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro 
145                 150                 155                 160 


Phe Leu Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr 
                165                 170                 175     


Arg Glu Leu Ala Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg 
            180                 185                 190         


Ala Cys Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly 
        195                 200                 205             


Pro Gln Ile Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr 
    210                 215                 220                 


Pro Gly Arg Leu Ile Asp Phe Leu Glu Cys Gly Lys Thr Asn Leu Arg 
225                 230                 235                 240 


Arg Thr Thr Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met 
                245                 250                 255     


Gly Phe Glu Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp 
            260                 265                 270         


Arg Gln Thr Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln 
        275                 280                 285             


Leu Ala Glu Asp Phe Leu Lys Asp Tyr Ile His Ile Asn Ile Gly Ala 
    290                 295                 300                 


Leu Glu Leu Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys 
305                 310                 315                 320 


His Asp Val Glu Lys Asp Glu Lys Leu Ile Arg Leu Met Glu Glu Ile 
                325                 330                 335     


Met Ser Glu Lys Glu Asn Lys Thr Ile Val Phe Val Glu Thr Lys Arg 
            340                 345                 350         


Arg Cys Asp Glu Leu Thr Arg Lys Met Arg Arg Asp Gly Trp Pro Ala 
        355                 360                 365             


Met Gly Ile His Gly Asp Lys Ser Gln Gln Glu Arg Asp Trp Val Leu 
    370                 375                 380                 


Asn Glu Phe Lys His Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val 
385                 390                 395                 400 


Ala Ser Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr 
                405                 410                 415     


Asp Tyr Pro Asn Ser Ser Glu Asp Tyr Ile His Arg Ile Gly Arg Thr 
            420                 425                 430         


Ala Arg Ser Thr Lys Thr Gly Thr Ala Tyr Thr Phe Phe Thr Pro Asn 
        435                 440                 445             


Asn Ile Lys Gln Val Ser Asp Leu Ile Ser Val Leu Arg Glu Ala Asn 
    450                 455                 460                 


Gln Ala Ile Asn Pro Lys Leu Leu Gln Leu Val Glu Asp Arg Gly Ser 
465                 470                 475                 480 


Gly Arg Ser Arg Gly Arg Gly Gly Met Lys Asp Asp Arg Arg Asp Arg 
                485                 490                 495     


Tyr Ser Ala Gly Lys Arg Gly Gly Phe Asn Thr Phe Arg Asp Arg Glu 
            500                 505                 510         


Asn Tyr Asp Arg Gly Tyr Ser Ser Leu Leu Lys Arg Asp Phe Gly Ala 
        515                 520                 525             


Lys Thr Gln Asn Gly Val Tyr Ser Ala Ala Asn Tyr Thr Asn Gly Ser 
    530                 535                 540                 


Phe Gly Ser Asn Phe Val Ser Ala Gly Ile Gln Thr Ser Phe Arg Thr 
545                 550                 555                 560 


Gly Asn Pro Thr Gly Thr Tyr Gln Asn Gly Tyr Asp Ser Thr Gln Gln 
                565                 570                 575     


Tyr Gly Ser Asn Val Pro Asn Met His Asn Gly Met Asn Gln Gln Ala 
            580                 585                 590         


Tyr Ala Tyr Pro Ala Thr Ala Ala Ala Pro Met Ile Gly Tyr Pro Met 
        595                 600                 605             


Pro Thr Gly Tyr Ser Gln 
    610                 


<210>  6
<211>  398
<212>  PRT
<213>  Bombyx mori

<400>  6

Ile Ala Val Lys Val Ser Gly Glu Asn Pro Pro Arg Pro Ile Glu Ser 
1               5                   10                  15      


Phe Glu Thr Ala Asn Leu Arg Lys Tyr Val Leu Asp Asn Val Leu Lys 
            20                  25                  30          


Ala Gly Tyr Arg Lys Pro Thr Pro Ile Gln Lys Asn Ala Ile Pro Ile 
        35                  40                  45              


Ile Met Ser Gly Arg Asp Leu Met Gly Cys Ala Gln Thr Gly Ser Gly 
    50                  55                  60                  


Lys Thr Ala Ala Phe Leu Val Pro Ile Ile Asn Met Leu Leu Gln Asp 
65                  70                  75                  80  


Pro Lys Asp Leu Ile Ser Glu Asn Gly Cys Ala Gln Pro Gln Val Ile 
                85                  90                  95      


Ile Val Ser Pro Thr Arg Glu Leu Thr Leu Gln Ile Phe Asn Glu Ala 
            100                 105                 110         


Arg Lys Phe Ser Tyr Gly Ser Val Leu Lys Val Ala Val Ala Tyr Gly 
        115                 120                 125             


Gly Thr Ala Val Arg His Gln Gly Asp Asn Ile Ala Arg Gly Cys His 
    130                 135                 140                 


Ile Leu Val Ala Thr Pro Gly Arg Leu His Asp Phe Val Glu Arg Asn 
145                 150                 155                 160 


Arg Val Ser Phe Gly Ser Val Arg Phe Val Val Leu Asp Gln Ala Asp 
                165                 170                 175     


Cys Met Leu Asp Met Gly Phe Met Pro Ser Ile Glu Lys Met Met Leu 
            180                 185                 190         


His Pro Thr Met Val Glu Thr Thr Lys Arg Gln Thr Leu Met Phe Ser 
        195                 200                 205             


Ala Thr Phe Pro Glu Asp Ile Gln His Leu Ala Gly Arg Phe Leu Asn 
    210                 215                 220                 


Asn Tyr Leu Phe Val Ala Val Gly Ile Val Gly Gly Ala Ser Thr Asp 
225                 230                 235                 240 


Val Glu Gln Ile Phe Ile Glu Val Thr Lys Tyr Glu Lys Arg Asn Ser 
                245                 250                 255     


Leu Lys Gln Leu Ile Glu Glu Asn Asp Gly Lys Arg Ile Leu Val Phe 
            260                 265                 270         


Val Glu Thr Lys Arg Asn Ala Asp Phe Ile Ala Ala Met Leu Ser Glu 
        275                 280                 285             


Gln Gln Leu Leu Thr Ser Ser Ile His Gly Asp Arg Met Gln Arg Glu 
    290                 295                 300                 


Arg Glu Glu Ala Leu Gln Asn Phe Lys Ser Gly Lys His Cys Ile Leu 
305                 310                 315                 320 


Val Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Lys Asn Val Asp 
                325                 330                 335     


Ile Val Val Asn Tyr Asp Leu Pro Lys Ser Ile Asp Glu Tyr Val His 
            340                 345                 350         


Arg Ile Gly Arg Thr Gly Arg Val Gly Asn Arg Gly Lys Ala Val Ser 
        355                 360                 365             


Phe Tyr Asp Ser Asp Gln Asp Leu Ala Leu Val Ala Asp Leu Ser Lys 
    370                 375                 380                 


Ile Leu Arg Gln Ala Asp Gln Ser Val Pro Asp Phe Leu Lys 
385                 390                 395             


<210>  7
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn Asn Pro 
                565                 570                 575     


Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly Val Lys 
            580                 585                 590         


Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser Glu Thr 
        595                 600                 605             


Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro Asn Ser 
    610                 615                 620                 


Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly Thr Tyr 
625                 630                 635                 640 


Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu Tyr Gly 
                645                 650                 655     


Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg Ser Ser 
            660                 665                 670         


Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly Gln Gln 
        675                 680                 685             


Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly Ala Thr 
    690                 695                 700                 


Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro Pro Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 


<210>  8
<211>  387
<212>  PRT
<213>  Bombyx mori

<400>  8

Gly Glu Asn Pro Pro Arg Pro Ile Glu Ser Phe Glu Thr Ala Asn Leu 
1               5                   10                  15      


Arg Lys Tyr Val Leu Asp Asn Val Leu Lys Ala Gly Tyr Arg Lys Pro 
            20                  25                  30          


Thr Pro Ile Gln Lys Asn Ala Ile Pro Ile Ile Met Ser Gly Arg Asp 
        35                  40                  45              


Leu Met Gly Cys Ala Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu 
    50                  55                  60                  


Val Pro Ile Ile Asn Met Leu Leu Gln Asp Pro Lys Asp Leu Ile Ser 
65                  70                  75                  80  


Glu Asn Gly Cys Ala Gln Pro Gln Val Ile Ile Val Ser Pro Thr Arg 
                85                  90                  95      


Glu Leu Thr Leu Gln Ile Phe Asn Glu Ala Arg Lys Phe Ser Tyr Gly 
            100                 105                 110         


Ser Val Leu Lys Val Ala Val Ala Tyr Gly Gly Thr Ala Val Arg His 
        115                 120                 125             


Gln Gly Asp Asn Ile Ala Arg Gly Cys His Ile Leu Val Ala Thr Pro 
    130                 135                 140                 


Gly Arg Leu His Asp Phe Val Glu Arg Asn Arg Val Ser Phe Gly Ser 
145                 150                 155                 160 


Val Arg Phe Val Val Leu Asp Gln Ala Asp Cys Met Leu Asp Met Gly 
                165                 170                 175     


Phe Met Pro Ser Ile Glu Lys Met Met Leu His Pro Thr Met Val Glu 
            180                 185                 190         


Thr Thr Lys Arg Gln Thr Leu Met Phe Ser Ala Thr Phe Pro Glu Asp 
        195                 200                 205             


Ile Gln His Leu Ala Gly Arg Phe Leu Asn Asn Tyr Leu Phe Val Ala 
    210                 215                 220                 


Val Gly Ile Val Gly Gly Ala Ser Thr Asp Val Glu Gln Ile Phe Ile 
225                 230                 235                 240 


Glu Val Thr Lys Tyr Glu Lys Arg Asn Ser Leu Lys Gln Leu Ile Glu 
                245                 250                 255     


Glu Asn Asp Gly Lys Arg Ile Leu Val Phe Val Glu Thr Lys Arg Asn 
            260                 265                 270         


Ala Asp Phe Ile Ala Ala Met Leu Ser Glu Gln Gln Leu Leu Thr Ser 
        275                 280                 285             


Ser Ile His Gly Asp Arg Met Gln Arg Glu Arg Glu Glu Ala Leu Gln 
    290                 295                 300                 


Asn Phe Lys Ser Gly Lys His Cys Ile Leu Val Ala Thr Ala Val Ala 
305                 310                 315                 320 


Ala Arg Gly Leu Asp Ile Lys Asn Val Asp Ile Val Val Asn Tyr Asp 
                325                 330                 335     


Leu Pro Lys Ser Ile Asp Glu Tyr Val His Arg Ile Gly Arg Thr Gly 
            340                 345                 350         


Arg Val Gly Asn Arg Gly Lys Ala Val Ser Phe Tyr Asp Ser Asp Gln 
        355                 360                 365             


Asp Leu Ala Leu Val Ala Asp Leu Ser Lys Ile Leu Arg Gln Ala Asp 
    370                 375                 380                 


Gln Ser Val 
385         


<210>  9
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Gly Lys Leu Arg Ser Asp Ala Gly Leu Glu Ser Asp Thr Ala 
1               5                   10                  15      


Met Lys Lys Gly Glu Thr Leu Arg Lys Gln Thr Glu Glu Lys Glu Lys 
            20                  25                  30          


Lys Glu Lys Pro Lys Ser Asp Lys Thr Glu Glu Ile Ala Glu Glu Glu 
        35                  40                  45              


Glu Thr Val Phe Pro Lys Ala Lys Gln Val Lys Lys Lys Ala Glu Pro 
    50                  55                  60                  


Ser Glu Val Asp Met Asn Ser Pro Lys Ser Lys Lys Ala Lys Lys Lys 
65                  70                  75                  80  


Glu Glu Pro Ser Gln Asn Asp Ile Ser Pro Lys Thr Lys Ser Leu Arg 
                85                  90                  95      


Lys Lys Lys Glu Pro Ile Glu Lys Lys Val Val Ser Ser Lys Thr Lys 
            100                 105                 110         


Lys Val Thr Lys Asn Glu Glu Pro Ser Glu Glu Glu Ile Asp Ala Pro 
        115                 120                 125             


Lys Pro Lys Lys Met Lys Lys Glu Lys Glu Met Asn Gly Glu Thr Arg 
    130                 135                 140                 


Glu Lys Ser Pro Lys Leu Lys Asn Gly Phe Pro His Pro Glu Pro Asp 
145                 150                 155                 160 


Cys Asn Pro Ser Glu Ala Ala Ser Glu Glu Ser Asn Ser Glu Ile Glu 
                165                 170                 175     


Gln Glu Ile Pro Val Glu Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro 
            180                 185                 190         


Ile Ser Glu Glu Thr Ile Lys Leu Leu Lys Gly Arg Gly Val Thr Phe 
        195                 200                 205             


Leu Phe Pro Ile Gln Ala Lys Thr Phe His His Val Tyr Ser Gly Lys 
    210                 215                 220                 


Asp Leu Ile Ala Gln Ala Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe 
225                 230                 235                 240 


Ala Ile Pro Leu Ile Glu Lys Leu His Gly Glu Leu Gln Asp Arg Lys 
                245                 250                 255     


Arg Gly Arg Ala Pro Gln Val Leu Val Leu Ala Pro Thr Arg Glu Leu 
            260                 265                 270         


Ala Asn Gln Val Ser Lys Asp Phe Ser Asp Ile Thr Lys Lys Leu Ser 
        275                 280                 285             


Val Ala Cys Phe Tyr Gly Gly Thr Pro Tyr Gly Gly Gln Phe Glu Arg 
    290                 295                 300                 


Met Arg Asn Gly Ile Asp Ile Leu Val Gly Thr Pro Gly Arg Ile Lys 
305                 310                 315                 320 


Asp His Ile Gln Asn Gly Lys Leu Asp Leu Thr Lys Leu Lys His Val 
                325                 330                 335     


Val Leu Asp Glu Val Asp Gln Met Leu Asp Met Gly Phe Ala Asp Gln 
            340                 345                 350         


Val Glu Glu Ile Leu Ser Val Ala Tyr Lys Lys Asp Ser Glu Asp Asn 
        355                 360                 365             


Pro Gln Thr Leu Leu Phe Ser Ala Thr Cys Pro His Trp Val Phe Asn 
    370                 375                 380                 


Val Ala Lys Lys Tyr Met Lys Ser Thr Tyr Glu Gln Val Asp Leu Ile 
385                 390                 395                 400 


Gly Lys Lys Thr Gln Lys Thr Ala Ile Thr Val Glu His Leu Ala Ile 
                405                 410                 415     


Lys Cys His Trp Thr Gln Arg Ala Ala Val Ile Gly Asp Val Ile Arg 
            420                 425                 430         


Val Tyr Ser Gly His Gln Gly Arg Thr Ile Ile Phe Cys Glu Thr Lys 
        435                 440                 445             


Lys Glu Ala Gln Glu Leu Ser Gln Asn Ser Ala Ile Lys Gln Asp Ala 
    450                 455                 460                 


Gln Ser Leu His Gly Asp Ile Pro Gln Lys Gln Arg Glu Ile Thr Leu 
465                 470                 475                 480 


Lys Gly Phe Arg Asn Gly Ser Phe Gly Val Leu Val Ala Thr Asn Val 
                485                 490                 495     


Ala Ala Arg Gly Leu Asp Ile Pro Glu Val Asp Leu Val Ile Gln Ser 
            500                 505                 510         


Ser Pro Pro Lys Asp Val Glu Ser Tyr Ile His Arg Ser Gly Arg Thr 
        515                 520                 525             


Gly Arg Ala Gly Arg Thr Gly Val Cys Ile Cys Phe Tyr Gln His Lys 
    530                 535                 540                 


Glu Glu Tyr Gln Leu Val Gln Val Glu Gln Lys Ala Gly Ile Lys Phe 
545                 550                 555                 560 


Lys Arg Ile Gly Val Pro Ser Ala Thr Glu Ile Ile Lys Ala Ser Ser 
                565                 570                 575     


Lys Asp Ala Ile Arg Leu Leu Asp Ser Val Pro Pro Thr Ala Ile Ser 
            580                 585                 590         


His Phe Lys Gln Ser Ala Glu Lys Leu Ile Glu Glu Lys Gly Ala Val 
        595                 600                 605             


Glu Ala Leu Ala Ala Ala Leu Ala His Ile Ser Gly Ala Thr Ser Val 
    610                 615                 620                 


Asp Gln Arg Ser Leu Ile Asn Ser Asn Val Gly Phe Val Thr Met Ile 
625                 630                 635                 640 


Leu Gln Cys Ser Ile Glu Met Pro Asn Ile Ser Tyr Ala Trp Lys Glu 
                645                 650                 655     


Leu Lys Glu Gln Leu Gly Glu Glu Ile Asp Ser Lys Val Lys Gly Met 
            660                 665                 670         


Val Phe Leu Lys Gly Lys Leu Gly Val Cys Phe Asp Val Pro Thr Ala 
        675                 680                 685             


Ser Val Thr Glu Ile Gln Glu Lys Trp His Asp Ser Arg Arg Trp Gln 
    690                 695                 700                 


Leu Ser Val Ala Thr Glu Gln Pro Glu Leu Glu Gly Pro Arg Glu Gly 
705                 710                 715                 720 


Tyr Gly Gly Phe Arg Gly Gln Arg Glu Gly Ser Arg Gly Phe Arg Gly 
                725                 730                 735     


Gln Arg Asp Gly Asn Arg Arg Phe Arg Gly Gln Arg Glu Gly Ser Arg 
            740                 745                 750         


Gly Pro Arg Gly Gln Arg Ser Gly Gly Gly Asn Lys Ser Asn Arg Ser 
        755                 760                 765             


Gln Asn Lys Gly Gln Lys Arg Ser Phe Ser Lys Ala Phe Gly Gln 
    770                 775                 780             


<210>  10
<211>  376
<212>  PRT
<213>  Bombyx mori

<400>  10

Pro Ile Glu Ser Phe Glu Thr Ala Asn Leu Arg Lys Tyr Val Leu Asp 
1               5                   10                  15      


Asn Val Leu Lys Ala Gly Tyr Arg Lys Pro Thr Pro Ile Gln Lys Asn 
            20                  25                  30          


Ala Ile Pro Ile Ile Met Ser Gly Arg Asp Leu Met Gly Cys Ala Gln 
        35                  40                  45              


Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Val Pro Ile Ile Asn Met 
    50                  55                  60                  


Leu Leu Gln Asp Pro Lys Asp Leu Ile Ser Glu Asn Gly Cys Ala Gln 
65                  70                  75                  80  


Pro Gln Val Ile Ile Val Ser Pro Thr Arg Glu Leu Thr Leu Gln Ile 
                85                  90                  95      


Phe Asn Glu Ala Arg Lys Phe Ser Tyr Gly Ser Val Leu Lys Val Ala 
            100                 105                 110         


Val Ala Tyr Gly Gly Thr Ala Val Arg His Gln Gly Asp Asn Ile Ala 
        115                 120                 125             


Arg Gly Cys His Ile Leu Val Ala Thr Pro Gly Arg Leu His Asp Phe 
    130                 135                 140                 


Val Glu Arg Asn Arg Val Ser Phe Gly Ser Val Arg Phe Val Val Leu 
145                 150                 155                 160 


Asp Gln Ala Asp Cys Met Leu Asp Met Gly Phe Met Pro Ser Ile Glu 
                165                 170                 175     


Lys Met Met Leu His Pro Thr Met Val Glu Thr Thr Lys Arg Gln Thr 
            180                 185                 190         


Leu Met Phe Ser Ala Thr Phe Pro Glu Asp Ile Gln His Leu Ala Gly 
        195                 200                 205             


Arg Phe Leu Asn Asn Tyr Leu Phe Val Ala Val Gly Ile Val Gly Gly 
    210                 215                 220                 


Ala Ser Thr Asp Val Glu Gln Ile Phe Ile Glu Val Thr Lys Tyr Glu 
225                 230                 235                 240 


Lys Arg Asn Ser Leu Lys Gln Leu Ile Glu Glu Asn Asp Gly Lys Arg 
                245                 250                 255     


Ile Leu Val Phe Val Glu Thr Lys Arg Asn Ala Asp Phe Ile Ala Ala 
            260                 265                 270         


Met Leu Ser Glu Gln Gln Leu Leu Thr Ser Ser Ile His Gly Asp Arg 
        275                 280                 285             


Met Gln Arg Glu Arg Glu Glu Ala Leu Gln Asn Phe Lys Ser Gly Lys 
    290                 295                 300                 


His Cys Ile Leu Val Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile 
305                 310                 315                 320 


Lys Asn Val Asp Ile Val Val Asn Tyr Asp Leu Pro Lys Ser Ile Asp 
                325                 330                 335     


Glu Tyr Val His Arg Ile Gly Arg Thr Gly Arg Val Gly Asn Arg Gly 
            340                 345                 350         


Lys Ala Val Ser Phe Tyr Asp Ser Asp Gln Asp Leu Ala Leu Val Ala 
        355                 360                 365             


Asp Leu Ser Lys Ile Leu Arg Gln 
    370                 375     


<210>  11
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gly Glu Leu Ala Asp Lys Lys Asp Arg Asp Ala Ser Pro Ser 
1               5                   10                  15      


Lys Glu Glu Arg Lys Arg Ser Arg Thr Pro Asp Arg Glu Arg Asp Arg 
            20                  25                  30          


Asp Arg Asp Arg Lys Ser Ser Pro Ser Lys Asp Arg Lys Arg His Arg 
        35                  40                  45              


Ser Arg Asp Arg Arg Arg Gly Gly Ser Arg Ser Arg Ser Arg Ser Arg 
    50                  55                  60                  


Ser Lys Ser Ala Glu Arg Glu Arg Arg His Lys Glu Arg Glu Arg Asp 
65                  70                  75                  80  


Lys Glu Arg Asp Arg Asn Lys Lys Asp Arg Asp Arg Asp Lys Asp Gly 
                85                  90                  95      


His Arg Arg Asp Lys Asp Arg Lys Arg Ser Ser Leu Ser Pro Gly Arg 
            100                 105                 110         


Gly Lys Asp Phe Lys Ser Arg Lys Asp Arg Asp Ser Lys Lys Asp Glu 
        115                 120                 125             


Glu Asp Glu His Gly Asp Lys Lys Pro Lys Ala Gln Pro Leu Ser Leu 
    130                 135                 140                 


Glu Glu Leu Leu Ala Lys Lys Lys Ala Glu Glu Glu Ala Glu Ala Lys 
145                 150                 155                 160 


Pro Lys Phe Leu Ser Lys Ala Glu Arg Glu Ala Glu Ala Leu Lys Arg 
                165                 170                 175     


Arg Gln Gln Glu Val Glu Glu Arg Gln Arg Met Leu Glu Glu Glu Arg 
            180                 185                 190         


Lys Lys Arg Lys Gln Phe Gln Asp Leu Gly Arg Lys Met Leu Glu Asp 
        195                 200                 205             


Pro Gln Glu Arg Glu Arg Arg Glu Arg Arg Glu Arg Met Glu Arg Glu 
    210                 215                 220                 


Thr Asn Gly Asn Glu Asp Glu Glu Gly Arg Gln Lys Ile Arg Glu Glu 
225                 230                 235                 240 


Lys Asp Lys Ser Lys Glu Leu His Ala Ile Lys Glu Arg Tyr Leu Gly 
                245                 250                 255     


Gly Ile Lys Lys Arg Arg Arg Thr Arg His Leu Asn Asp Arg Lys Phe 
            260                 265                 270         


Val Phe Glu Trp Asp Ala Ser Glu Asp Thr Ser Ile Asp Tyr Asn Pro 
        275                 280                 285             


Leu Tyr Lys Glu Arg His Gln Val Gln Leu Leu Gly Arg Gly Phe Ile 
    290                 295                 300                 


Ala Gly Ile Asp Leu Lys Gln Gln Lys Arg Glu Gln Ser Arg Phe Tyr 
305                 310                 315                 320 


Gly Asp Leu Met Glu Lys Arg Arg Thr Leu Glu Glu Lys Glu Gln Glu 
                325                 330                 335     


Glu Ala Arg Leu Arg Lys Leu Arg Lys Lys Glu Ala Lys Gln Arg Trp 
            340                 345                 350         


Asp Asp Arg His Trp Ser Gln Lys Lys Leu Asp Glu Met Thr Asp Arg 
        355                 360                 365             


Asp Trp Arg Ile Phe Arg Glu Asp Tyr Ser Ile Thr Thr Lys Gly Gly 
    370                 375                 380                 


Lys Ile Pro Asn Pro Ile Arg Ser Trp Lys Asp Ser Ser Leu Pro Pro 
385                 390                 395                 400 


His Ile Leu Glu Val Ile Asp Lys Cys Gly Tyr Lys Glu Pro Thr Pro 
                405                 410                 415     


Ile Gln Arg Gln Ala Ile Pro Ile Gly Leu Gln Asn Arg Asp Ile Ile 
            420                 425                 430         


Gly Val Ala Glu Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Ile Pro 
        435                 440                 445             


Leu Leu Val Trp Ile Thr Thr Leu Pro Lys Ile Asp Arg Ile Glu Glu 
    450                 455                 460                 


Ser Asp Gln Gly Pro Tyr Ala Ile Ile Leu Ala Pro Thr Arg Glu Leu 
465                 470                 475                 480 


Ala Gln Gln Ile Glu Glu Glu Thr Ile Lys Phe Gly Lys Pro Leu Gly 
                485                 490                 495     


Ile Arg Thr Val Ala Val Ile Gly Gly Ile Ser Arg Glu Asp Gln Gly 
            500                 505                 510         


Phe Arg Leu Arg Met Gly Cys Glu Ile Val Ile Ala Thr Pro Gly Arg 
        515                 520                 525             


Leu Ile Asp Val Leu Glu Asn Arg Tyr Leu Val Leu Ser Arg Cys Thr 
    530                 535                 540                 


Tyr Val Val Leu Asp Glu Ala Asp Arg Met Ile Asp Met Gly Phe Glu 
545                 550                 555                 560 


Pro Asp Val Gln Lys Ile Leu Glu His Met Pro Val Ser Asn Gln Lys 
                565                 570                 575     


Pro Asp Thr Asp Glu Ala Glu Asp Pro Glu Lys Met Leu Ala Asn Phe 
            580                 585                 590         


Glu Ser Gly Lys His Lys Tyr Arg Gln Thr Val Met Phe Thr Ala Thr 
        595                 600                 605             


Met Pro Pro Ala Val Glu Arg Leu Ala Arg Ser Tyr Leu Arg Arg Pro 
    610                 615                 620                 


Ala Val Val Tyr Ile Gly Ser Ala Gly Lys Pro His Glu Arg Val Glu 
625                 630                 635                 640 


Gln Lys Val Phe Leu Met Ser Glu Ser Glu Lys Arg Lys Lys Leu Leu 
                645                 650                 655     


Ala Ile Leu Glu Gln Gly Phe Asp Pro Pro Ile Ile Ile Phe Val Asn 
            660                 665                 670         


Gln Lys Lys Gly Cys Asp Val Leu Ala Lys Ser Leu Glu Lys Met Gly 
        675                 680                 685             


Tyr Asn Ala Cys Thr Leu His Gly Gly Lys Gly Gln Glu Gln Arg Glu 
    690                 695                 700                 


Phe Ala Leu Ser Asn Leu Lys Ala Gly Ala Lys Asp Ile Leu Val Ala 
705                 710                 715                 720 


Thr Asp Val Ala Gly Arg Gly Ile Asp Ile Gln Asp Val Ser Met Val 
                725                 730                 735     


Val Asn Tyr Asp Met Ala Lys Asn Ile Glu Asp Tyr Ile His Arg Ile 
            740                 745                 750         


Gly Arg Thr Gly Arg Ala Gly Lys Ser Gly Val Ala Ile Thr Phe Leu 
        755                 760                 765             


Thr Lys Glu Asp Ser Ala Val Phe Tyr Glu Leu Lys Gln Ala Ile Leu 
    770                 775                 780                 


Glu Ser Pro Val Ser Ser Cys Pro Pro Glu Leu Ala Asn His Pro Asp 
785                 790                 795                 800 


Ala Gln His Lys Pro Gly Thr Ile Leu Thr Lys Lys Arg Arg Glu Glu 
                805                 810                 815     


Thr Ile Phe Ala 
            820 


<210>  12
<211>  385
<212>  PRT
<213>  Drosophila melanogaster

<400>  12

Val Lys Val Thr Gly Ser Asp Val Pro Gln Pro Ile Gln His Phe Thr 
1               5                   10                  15      


Ser Ala Asp Leu Arg Asp Ile Ile Ile Asp Asn Val Asn Lys Ser Gly 
            20                  25                  30          


Tyr Lys Ile Pro Thr Pro Ile Gln Lys Cys Ser Ile Pro Val Ile Ser 
        35                  40                  45              


Ser Gly Arg Asp Leu Met Ala Cys Ala Gln Thr Gly Ser Gly Lys Thr 
    50                  55                  60                  


Ala Ala Phe Leu Leu Pro Ile Leu Ser Lys Leu Leu Glu Asp Pro His 
65                  70                  75                  80  


Glu Leu Glu Leu Gly Arg Pro Gln Val Val Ile Val Ser Pro Thr Arg 
                85                  90                  95      


Glu Leu Ala Ile Gln Ile Phe Asn Glu Ala Arg Lys Phe Ala Phe Glu 
            100                 105                 110         


Ser Tyr Leu Lys Ile Gly Ile Val Tyr Gly Gly Thr Ser Phe Arg His 
        115                 120                 125             


Gln Asn Glu Cys Ile Thr Arg Gly Cys His Val Val Ile Ala Thr Pro 
    130                 135                 140                 


Gly Arg Leu Leu Asp Phe Val Asp Arg Thr Phe Ile Thr Phe Glu Asp 
145                 150                 155                 160 


Thr Arg Phe Val Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly 
                165                 170                 175     


Phe Ser Glu Asp Met Arg Arg Ile Met Thr His Val Thr Met Arg Pro 
            180                 185                 190         


Glu His Gln Thr Leu Met Phe Ser Ala Thr Phe Pro Glu Glu Ile Gln 
        195                 200                 205             


Arg Met Ala Gly Glu Phe Leu Lys Asn Tyr Val Phe Val Ala Ile Gly 
    210                 215                 220                 


Ile Val Gly Gly Ala Cys Ser Asp Val Lys Gln Thr Ile Tyr Glu Val 
225                 230                 235                 240 


Asn Lys Tyr Ala Lys Arg Ser Lys Leu Ile Glu Ile Leu Ser Glu Gln 
                245                 250                 255     


Ala Asp Gly Thr Ile Val Phe Val Glu Thr Lys Arg Gly Ala Asp Phe 
            260                 265                 270         


Leu Ala Ser Phe Leu Ser Glu Lys Glu Phe Pro Thr Thr Ser Ile His 
        275                 280                 285             


Gly Asp Arg Leu Gln Ser Gln Arg Glu Gln Ala Leu Arg Asp Phe Lys 
    290                 295                 300                 


Asn Gly Ser Met Lys Val Leu Ile Ala Thr Ser Val Ala Ser Arg Gly 
305                 310                 315                 320 


Leu Asp Ile Lys Asn Ile Lys His Val Ile Asn Tyr Asp Met Pro Ser 
                325                 330                 335     


Lys Ile Asp Asp Tyr Val His Arg Ile Gly Arg Thr Gly Arg Val Gly 
            340                 345                 350         


Asn Asn Gly Arg Ala Thr Ser Phe Phe Asp Pro Glu Lys Asp Arg Ala 
        355                 360                 365             


Ile Ala Ala Asp Leu Val Lys Ile Leu Glu Gly Ser Gly Gln Thr Val 
    370                 375                 380                 


Pro 
385 


<210>  13
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  r36mer

<400>  13
accagcuuug uuccuugggu ucuugggagc agcagg                                 36


<210>  14
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  r18mer_FAM

<400>  14
cccaagaacc caaggaac                                                     18


