                         б

<110>  Ӣ̩＼޹˾
 
<120>  CD19CD22˫еSTAR

<130>  P2022TC1976

<150>  202110213821.3
<151>  2021-02-25

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  2
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  3
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  3

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  4
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  artificial sequence

<400>  4

Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Asp Ser 
1               5                   10                  15      


Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys 
            20                  25                  30          


Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met 
        35                  40                  45              


Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln 
    50                  55                  60                  


Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr 
65                  70                  75                  80  


Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe 
                85                  90                  95      


Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu 
            100                 105                 110         


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
        115                 120                 125             


Arg Leu Trp Ser Ser 
    130             


<210>  5
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  6
<211>  172
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
145                 150                 155                 160 


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170         


<210>  7
<211>  172
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  7

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
145                 150                 155                 160 


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170         


<210>  8
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  8

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Ala Glu Ile Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
            20                  25                  30          


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
        35                  40                  45              


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
    50                  55                  60                  


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
65                  70                  75                  80  


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
                85                  90                  95      


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
            100                 105                 110         


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
        115                 120                 125             


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
    130                 135                 140                 


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
145                 150                 155                 160 


Val Lys Arg Lys Asn Ser 
                165     


<210>  9
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  9

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  10

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  11
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  13

Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro 
1               5                   10                  15      


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
            20                  25                  30          


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
        35                  40                  45              


Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    50                  55          


<210>  14
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  14

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  16

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
                245                 250                 255     


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
            260                 265                 270         


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
        275                 280                 285             


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
    290                 295                 300                 


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
305                 310                 315                 320 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
                325                 330                 335     


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
            340                 345                 350         


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
        355                 360                 365             


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    370                 375                 


<210>  17
<211>  478
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr 
                165                 170                 175     


Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg 
            180                 185                 190         


Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu 
        195                 200                 205             


Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
    210                 215                 220                 


Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Met Val Thr Val Ser Ser Glu Phe Ser His Phe Val Pro Val Phe Leu 
                245                 250                 255     


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
305                 310                 315                 320 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
                325                 330                 335     


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
            340                 345                 350         


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
        355                 360                 365             


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
    370                 375                 380                 


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
385                 390                 395                 400 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
                405                 410                 415     


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
            420                 425                 430         


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
        435                 440                 445             


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
    450                 455                 460                 


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
465                 470                 475             


<210>  18
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  18

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
                245                 250                 255     


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
            260                 265                 270         


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
        275                 280                 285             


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
    290                 295                 300                 


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
305                 310                 315                 320 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
                325                 330                 335     


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
            340                 345                 350         


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
        355                 360                 365             


Asn Leu Leu Met Thr Leu Arg Leu Trp Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Asp Gln Arg Leu Pro Pro 
385                 390                 395                 400 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                405                 410                 415     


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            420                 425                 


<210>  19
<211>  478
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr 
                165                 170                 175     


Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg 
            180                 185                 190         


Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu 
        195                 200                 205             


Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
    210                 215                 220                 


Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Met Val Thr Val Ser Ser Glu Phe Ser His Phe Val Pro Val Phe Leu 
                245                 250                 255     


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
305                 310                 315                 320 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
                325                 330                 335     


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
            340                 345                 350         


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
        355                 360                 365             


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
    370                 375                 380                 


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
385                 390                 395                 400 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
                405                 410                 415     


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
            420                 425                 430         


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
        435                 440                 445             


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
    450                 455                 460                 


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
465                 470                 475             


<210>  20
<211>  415
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  20

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
                245                 250                 255     


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
            260                 265                 270         


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
        275                 280                 285             


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
    290                 295                 300                 


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
305                 310                 315                 320 


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
                325                 330                 335     


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
            340                 345                 350         


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
        355                 360                 365             


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
    370                 375                 380                 


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
385                 390                 395                 400 


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                405                 410                 415 


<210>  21
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  21

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  22
<211>  478
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr 
                165                 170                 175     


Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg 
            180                 185                 190         


Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu 
        195                 200                 205             


Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
    210                 215                 220                 


Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Met Val Thr Val Ser Ser Glu Phe Ser His Phe Val Pro Val Phe Leu 
                245                 250                 255     


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
305                 310                 315                 320 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
                325                 330                 335     


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
            340                 345                 350         


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
        355                 360                 365             


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
    370                 375                 380                 


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
385                 390                 395                 400 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
                405                 410                 415     


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
            420                 425                 430         


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
        435                 440                 445             


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
    450                 455                 460                 


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
465                 470                 475             


<210>  23
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  23

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  24
<211>  711
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  24

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
        115                 120                 125             


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
    130                 135                 140                 


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
145                 150                 155                 160 


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
                165                 170                 175     


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
            180                 185                 190         


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
    210                 215                 220                 


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Thr Ser 
225                 230                 235                 240 


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
                245                 250                 255     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            260                 265                 270         


Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn 
        275                 280                 285             


Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala 
    290                 295                 300                 


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly 
305                 310                 315                 320 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
                325                 330                 335     


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe 
            340                 345                 350         


Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val 
        355                 360                 365             


Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu 
    370                 375                 380                 


Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val 
385                 390                 395                 400 


Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val 
                405                 410                 415     


Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg 
            420                 425                 430         


Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met 
        435                 440                 445             


Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His 
    450                 455                 460                 


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
465                 470                 475                 480 


Ser Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
                485                 490                 495     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            500                 505                 510         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        515                 520                 525             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    530                 535                 540                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
545                 550                 555                 560 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                565                 570                 575     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            580                 585                 590         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        595                 600                 605             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    610                 615                 620                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
625                 630                 635                 640 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                645                 650                 655     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            660                 665                 670         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        675                 680                 685             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    690                 695                 700                 


Met Gln Ala Leu Pro Pro Arg 
705                 710     


<210>  25
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  25

Gly Val Ser Leu Pro Asp Tyr Gly 
1               5               


<210>  26
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  26

Ile Trp Gly Ser Glu Thr Thr 
1               5           


<210>  27
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  27

Ala Lys 
1       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  28

Gln Asp Ile Ser Lys Tyr 
1               5       


<210>  29
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  29

His Thr Ser 
1           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  30

Gln Gln Gly Asn Thr Leu Pro 
1               5           


<210>  31
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  31

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  32

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  33
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  33

Ala Arg 
1       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  34

Gln Thr Ile Trp Ser Tyr 
1               5       


<210>  35
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  35

Ala Ala Ser 
1           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  36

Gln Gln Ser Tyr Ser Ile Pro 
1               5           


<210>  37
<211>  375
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  37

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
                245                 250                 255     


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
            260                 265                 270         


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
        275                 280                 285             


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
    290                 295                 300                 


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
305                 310                 315                 320 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
                325                 330                 335     


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
            340                 345                 350         


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
        355                 360                 365             


Thr Leu Arg Leu Trp Ser Ser 
    370                 375 


<210>  38
<211>  472
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr 
                165                 170                 175     


Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg 
            180                 185                 190         


Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu 
        195                 200                 205             


Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
    210                 215                 220                 


Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Met Val Thr Val Ser Ser Glu Phe Ser His Phe Val Pro Val Phe Leu 
                245                 250                 255     


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu 
305                 310                 315                 320 


Pro Ser Ala Glu Ile Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
                325                 330                 335     


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
            340                 345                 350         


Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
        355                 360                 365             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
    370                 375                 380                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
385                 390                 395                 400 


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
                405                 410                 415     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            420                 425                 430         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        435                 440                 445             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
    450                 455                 460                 


Ala Met Val Lys Arg Lys Asn Ser 
465                 470         


<210>  39
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  39

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp 
    130                 135 


<210>  40
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  40

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp 
    130                 135 


<210>  41
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  41

Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Asp Ser 
1               5                   10                  15      


Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys 
            20                  25                  30          


Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met 
        35                  40                  45              


Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln 
    50                  55                  60                  


Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr 
65                  70                  75                  80  


Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe 
                85                  90                  95      


Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu 
            100                 105                 110         


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
        115                 120                 125             


Arg Leu Trp 
    130     


<210>  42
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  42

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
145                 150                 155                 160 


Leu Val Val Met Ala Met 
                165     


<210>  43
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  43

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
145                 150                 155                 160 


Leu Val Val Met Ala Met 
                165     


<210>  44
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  44

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Ala Glu Ile Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
            20                  25                  30          


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
        35                  40                  45              


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
    50                  55                  60                  


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
65                  70                  75                  80  


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
                85                  90                  95      


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
            100                 105                 110         


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
        115                 120                 125             


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
    130                 135                 140                 


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
145                 150                 155                 160 


<210>  45
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  45

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala 
            100                 105             


<210>  46
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ser Gly Tyr Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  47
<211>  418
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  47

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser 
                165                 170                 175     


Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr 
    210                 215                 220                 


Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ala Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
                245                 250                 255     


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
            260                 265                 270         


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
        275                 280                 285             


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
    290                 295                 300                 


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
305                 310                 315                 320 


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
                325                 330                 335     


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
            340                 345                 350         


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
        355                 360                 365             


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
    370                 375                 380                 


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
385                 390                 395                 400 


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
                405                 410                 415     


Asn Ser 
        


<210>  48
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  48

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
                245                 250                 255     


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
            260                 265                 270         


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
        275                 280                 285             


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
    290                 295                 300                 


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
305                 310                 315                 320 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
                325                 330                 335     


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
            340                 345                 350         


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
        355                 360                 365             


Asn Leu Leu Met Thr Leu Arg Leu Trp Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Asp Gln Arg Leu Pro Pro 
385                 390                 395                 400 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                405                 410                 415     


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            420                 425                 


<210>  49
<211>  421
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  49

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
    130                 135                 140                 


Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr Asp Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr 
                165                 170                 175     


Ile Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His 
    210                 215                 220                 


Ser Gly Tyr Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ala Glu Asp Leu Arg Asn Val Thr Pro 
                245                 250                 255     


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
            260                 265                 270         


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
        275                 280                 285             


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
    290                 295                 300                 


Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
305                 310                 315                 320 


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
                325                 330                 335     


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
            340                 345                 350         


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
        355                 360                 365             


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
    370                 375                 380                 


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
385                 390                 395                 400 


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
                405                 410                 415     


Lys Arg Lys Asn Ser 
            420     


<210>  50
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  50

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
                245                 250                 255     


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
            260                 265                 270         


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
        275                 280                 285             


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
    290                 295                 300                 


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
305                 310                 315                 320 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
                325                 330                 335     


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
            340                 345                 350         


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
        355                 360                 365             


Asn Leu Leu Met Thr Leu Arg Leu Trp Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Asp Gln Arg Leu Pro Pro 
385                 390                 395                 400 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                405                 410                 415     


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            420                 425                 


<210>  51
<211>  423
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  51

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
145                 150                 155                 160 


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
                165                 170                 175     


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg His Ser Gly Tyr Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ala Glu Asp Leu Arg Asn Val 
                245                 250                 255     


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
            260                 265                 270         


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
        275                 280                 285             


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
    290                 295                 300                 


Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr 
305                 310                 315                 320 


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
                325                 330                 335     


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
            340                 345                 350         


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
        355                 360                 365             


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
    370                 375                 380                 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
385                 390                 395                 400 


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala 
                405                 410                 415     


Met Val Lys Arg Lys Asn Ser 
            420             


<210>  52
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  52

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
                245                 250                 255     


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
            260                 265                 270         


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
        275                 280                 285             


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
    290                 295                 300                 


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
305                 310                 315                 320 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
                325                 330                 335     


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
            340                 345                 350         


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
        355                 360                 365             


Asn Leu Leu Met Thr Leu Arg Leu Trp Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Asp Gln Arg Leu Pro Pro 
385                 390                 395                 400 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                405                 410                 415     


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            420                 425                 


<210>  53
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  53

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser 
                165                 170                 175     


Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr 
    210                 215                 220                 


Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ala Glu Phe Ser His Phe Val Pro Val Phe Leu Pro 
                245                 250                 255     


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
305                 310                 315                 320 


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
                325                 330                 335     


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            340                 345                 350         


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
        355                 360                 365             


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
    370                 375                 380                 


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
385                 390                 395                 400 


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
                405                 410                 415     


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
            420                 425                 430         


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
        435                 440                 445             


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
    450                 455                 460                 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
465                 470                 475         


<210>  54
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  54

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
                245                 250                 255     


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
            260                 265                 270         


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
        275                 280                 285             


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
    290                 295                 300                 


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
305                 310                 315                 320 


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
                325                 330                 335     


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
            340                 345                 350         


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
        355                 360                 365             


Asn Leu Leu Met Thr Leu Arg Leu Trp Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Asp Gln Arg Leu Pro Pro 
385                 390                 395                 400 


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                405                 410                 415     


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            420                 425                 


<210>  55
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  55

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  56
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  56

Tyr Thr Ser 
1           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  57

Gln Gln Gly Asn Thr Leu Pro 
1               5           


<210>  58
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  58

Gly Phe Ala Phe Ser Ile Tyr Asp 
1               5               


<210>  59
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  59

Ile Ser Ser Gly Gly Gly Thr 
1               5           


<210>  60
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  60

Ala Arg 
1       


<210>  61
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  61

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  62
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  62

Tyr Thr Ser 
1           


<210>  63
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  63

Gln Gln Gly Asn Thr Leu Pro 
1               5           


<210>  64
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  64

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala 
            100                 105             


<210>  65
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  65

Gly Phe Ala Phe Ser Ile Tyr Asp 
1               5               


<210>  66
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  66

Ile Ser Ser Gly Gly Gly Thr 
1               5           


<210>  67
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  67

Ala Arg 
1       


<210>  68
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  69
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  69

Gln Ser Phe Ser Asn Met 
1               5       


<210>  70
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  70

Gly Val Ser 
1           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  71

Gln Gln Tyr Gly Asp Trp Pro 
1               5           


<210>  72
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  72

Arg Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Phe Ser Asn Met 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Thr Arg Ala Ala Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Trp Pro Arg 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Arg Lys 
            100                 105             


<210>  73
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  73

Gly Phe Thr Phe Asp Asp Tyr Gly 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  74

Ile Asn Trp Asn Gly Gly Ser Thr 
1               5               


<210>  75
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  75

Ala Arg 
1       


<210>  76
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  76

Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys Ala 
                85                  90                  95      


Arg Gly Gly Asp Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  77
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  77

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  78
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  78

Tyr Thr Ser 
1           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  79

Gln Gln Gly Asn Thr Leu Pro 
1               5           


<210>  80
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  80

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Gln Ile Lys Arg 
            100                 105             


<210>  81
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  81

Gly Phe Thr Phe Ser Ile Tyr Asp 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  82

Ile Ser Ser Gly Gly Gly Thr Thr 
1               5               


<210>  83
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  83

Ala Arg 
1       


<210>  84
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Gly Ser Ser Tyr Gly Val Leu Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


