                         б

<110>  ɽ̴Ƽ޹˾
 
<120>  ǻͻ弰Ӧ

<130>  P2021TC1938

<150>  202110212498.8
<151>  2021-02-25

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  2
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-212(C102S; C130S;)

<400>  2

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  3
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-233   K86C C90E C102A C130A

<400>  3

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Cys Lys Pro Asp Glu Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  4
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-203       I80C C90S C102S C130S

<400>  4

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Cys 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  5
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-240 (K108E; C90E; C130A; E62K; H65G)

<400>  5

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Lys Arg Glu 
    50                  55                  60                  


Gly Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Glu Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  6
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-241(K108E; N98DC90E; C130A; E62K; H65G)

<400>  6

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Lys Arg Glu 
    50                  55                  60                  


Gly Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asp Ala Met Glu Cys Ala Leu His Leu Glu Glu Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  7
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-242(K108E; N98DR156HC90E; C130A; E62K; H65G)

<400>  7

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Lys Arg Glu 
    50                  55                  60                  


Gly Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asp Ala Met Glu Cys Ala Leu His Leu Glu Glu Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu His Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  8
<211>  182
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mut-HFn-243(K108E; N98DR156HC102A; C130A; E62K; H65G)

<400>  8

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Lys Arg Glu 
    50                  55                  60                  


Gly Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asp Ala Met Glu Ala Ala Leu His Leu Glu Glu Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu His Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  9
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  9
accacggcta gtacctcaca ggttcgtcag aattatcatc aggatagtga agcagccatt       60

aatcgccaga tcaatctgga actgtatgcg agctatgtgt atctgagtat gtcttattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgtgg cggtcgtatc      240

tttcttcagg atattaaaaa accggattgt gatgattggg aaagcggcct gaatgctatg      300

gaatgcgcct tacatttaga aaaaaatgtt aatcagagcc tgctggaact gcataaactg      360

gcaacggata aaaatgatcc gcatctgtgt gattttatcg aaacacatta tttaaatgaa      420

caggttaaag caatcaaaga actgggcgat catgttacca atttacgcaa aatgggtgct      480

ccggaaagtg gcctggccga atatctgttt gataaacata cgttaggcga tagcgataat      540

gaatct                                                                 546


<210>  10
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-212ĺ

<400>  10
accaccgcct ctacctcaca ggttcgtcag aattatcatc aggatagtga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgcg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgtgg tggtcgcatt      240

tttctgcagg atattaaaaa accggattgt gatgattggg aaagtggcct gaatgctatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagtcac tgctggaatt acataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggtgat catgttacca atttacgtaa aatgggcgca      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagcgataat      540

gaatct                                                                 546


<210>  11
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-233ĺ

<400>  11
accaccgcct ctacctcaca ggtgcgtcag aattatcatc aggatagcga agcagccatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgtg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgcgg tggtcgcatt      240

tttctgcagg atatttgtaa accggatagc gatgattggg aaagtggcct gaatgcaatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagtcac tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  12
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-203ĺ

<400>  12
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgcg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgtgg tggtcgttgt      240

tttctgcagg atattaaaaa accggatagc gatgattggg aaagtggcct gaatgctatg      300

gaaagtgcct tacatttaga aaaaaatgtt aatcagtctc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggtgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  13
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-240ĺ

<400>  13
accaccgcct ctacctcaca ggtgcgtcag aattatcatc aggatagcga agcagcaatt       60

aatcgtcaga ttaatctgga actgtatgca agctatgtgt atctgagtat gtcttattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaaaaacgcg aaggcgccga aaaactgatg aaactccaaa atcagcgtgg tggtcgcatt      240

tttttgcaag atattaaaaa accggatgaa gatgattggg aaagcggcct gaatgcgatg      300

gaatgtgcct tacatttaga agaaaatgtt aatcagagcc tgctggaact gcataaatta      360

gcaaccgata aaaatgatcc gcatctggcc gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggtgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaaagt                                                                 546


<210>  14
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-241ĺ

<400>  14
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagtga agcagccatt       60

aatcgccaga ttaatttaga actgtatgcc agctacgtgt atctgtctat gagctattat      120

tttgatcgtg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagagtcat      180

gaaaaacgcg aaggcgccga aaaactgatg aaattacaga atcagcgcgg tggtcgtatt      240

tttctccagg atattaaaaa accggatgaa gatgattggg aaagtggctt agatgcaatg      300

gaatgtgcct tacatctgga agaaaatgtt aatcagtctc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctggcc gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggcgat catgtgacca atttacgtaa aatgggtgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagcgataat      540

gaatct                                                                 546


<210>  15
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-242ĺ

<400>  15
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagccatt       60

aatcgtcaga ttaatttaga actgtatgca agctatgtgt atctgtctat gagctattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaaaaacgcg aaggcgccga aaaactgatg aaattacaga atcagcgtgg tggtcgtatt      240

tttcttcagg atattaaaaa accggatgaa gatgattggg aaagtggctt agatgcgatg      300

gaatgtgcct tacatctgga agaaaatgtt aatcagagtc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatttagcc gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggtgat catgtgacca atttacataa aatgggcgcc      480

ccggaaagcg gcctggccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  16
<211>  546
<212>  DNA
<213>  artificial sequence

<220>
<223>  Mut-HFn-243ĺ

<400>  16
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagtga agccgccatt       60

aatcgccaga ttaatctgga actgtatgca agctatgtgt atctgagtat gtcttattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaaaaacgcg aaggtgccga aaaactgatg aaattacaga atcagcgtgg tggtcgtatt      240

tttttacaag atattaaaaa accggattgt gatgattggg aaagtggctt agatgcaatg      300

gaagcagcct tacatttaga agaaaatgtt aatcagagcc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatttagca gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgtgacca atttacataa aatgggcgcc      480

ccggaaagcg gcctggccga atatctgttt gataaacata ccttaggcga tagcgataat      540

gaatct                                                                 546


<210>  17
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val 
1               5                   10                  15      


Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser 
            20                  25                  30          


Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser 
        35                  40                  45              


His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg 
    50                  55                  60                  


Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp 
65                  70                  75                  80  


Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met 
                85                  90                  95      


Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp 
            100                 105                 110         


Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe 
        115                 120                 125             


Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met 
    130                 135                 140                 


Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly 
145                 150                 155                 160 


Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 


