                         б

<110>  ϺҽҩƼ޹˾; ż޹˾

<120>  Siglec-15ϵ׵Ʊ;

<130>  0134-PA-023

<160>  41

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3 0+2+3+5+6+7+9+13+15

<400>  1

Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu 
1               5                   10              


<210>  2
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2 0+2+9

<400>  2

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2 3+13+15

<400>  3

Thr Gly Gly Gly Glu Ser 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2 5

<400>  4

Tyr Gly Gly Gly Gly Ser 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2 6

<400>  5

Trp Gly Gly Gly Gly Ser 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2 7

<400>  6

Ser Gly Gly Gly Val Tyr 
1               5       


<210>  7
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1 0+3+5+6+7+9+13+15

<400>  7

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1 2

<400>  8

Gly Phe Thr Ser Ser Ser Tyr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3 0+2+3+5+6+7+9+13+15

<400>  9

Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2 0+2+3+5+6+7+9

<400>  10

Val Ala Ser Ser Leu Gln Ser 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2 13

<400>  11

Val Ala Ser Phe Glu His Arg 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2 15

<400>  12

Val Ala Ser Tyr Ile His Ser 
1               5           


<210>  13
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1 0+2+3+5+6+7+13+15

<400>  13

Arg Ala Ser Gln Asp Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1 9

<400>  14

Arg Ala Ser Gln Asp Ile Ser Asp Trp Leu Ala 
1               5                   10      


<210>  15
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  16
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2

<400>  16

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Thr Ile 
            


<210>  17
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  17

Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
        35                  40      


<210>  18
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4

<400>  18

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR1

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  20
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2

<400>  20

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  21
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3

<400>  21

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  22
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4

<400>  22

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  23
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH 0+9

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  24
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH 2

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH 3+13+15

<400>  25

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Thr Gly Gly Gly Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  26
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH 5

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Tyr Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  27
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH 6

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Trp Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH 7

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Val Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL 0+2+3+5+7

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL 9

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asp Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL 13

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Phe Glu His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  32
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL 15

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Tyr Ile His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2 ͨʽ

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = SerThrTrpTyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GluGlyVal

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = SerTyr

<400>  33

Xaa Gly Gly Gly Xaa Xaa 
1               5       


<210>  34
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1 ͨʽ

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = PheSer

<400>  34

Gly Phe Thr Xaa Ser Ser Tyr 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2 ͨʽ

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = PheSerTyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GluIleLeu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = HisGln

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = ArgSer

<400>  35

Val Ala Ser Xaa Xaa Xaa Xaa 
1               5           


<210>  36
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1 ͨʽ

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AspSer

<400>  36

Arg Ala Ser Gln Asp Ile Ser Xaa Trp Leu Ala 
1               5                   10      


<210>  37
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH ͨʽ

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = PheSer

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa = SerThrTrpTyr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = GluGlyVal

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = SerTyr

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Xaa Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Xaa Gly Gly Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ile Gly Ser Ser Trp Tyr Ser Asp Ala Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL ͨʽ

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa = PheSerTyr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = GluIleLeu

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = HisGln

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = ArgSer

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Xaa Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Xaa Xaa Xaa Xaa Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  330
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  40
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  40

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  41
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T2A

<400>  41

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      
