                         SEQUENCE LISTING

<110>  Yale University
 
<120>  Targeted Bifunctional Degraders

<130>  047162-7304WO1 (01588)

<150>  US 63/152,110
<151>  2021-02-22

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  1

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr Cys 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  can be Lys or Cys or absent

<400>  2

Thr Trp Pro Lys His Phe Asp Lys His Thr Phe Tyr Ser Ile Leu Lys 
1               5                   10                  15      


Leu Gly Lys His 
            20  


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  terminal Lys residue optionally Cys, each with C(=O)-NH2 terminus

<400>  3

Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys Lys 
1               5                   10              


<210>  4
<211>  23
<212>  PRT
<213>  Arificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  terminal residue is Lys or Cys or absent, when present terminus 
       is C(=O)-NH2 or C(=O)-OH terminus

<400>  4

Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile 
1               5                   10                  15      


Ala His Glu Lys Leu Arg Lys 
            20              


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = (R)-2-(7-octenyl) Ala

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  hydrocarbon bridge

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = (S)-2-(4-pentenyl)Ala

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  terminal residue is Lys or Cys or absent, when present terminus 
       is C(=O)-NH2 or C(=O)-OH

<400>  5

Xaa Ala Lys Ile Glu Lys His Xaa His Tyr Gln Lys Lys 
1               5                   10              


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  terminal Leucine has terminal C(=O)-NH2 or (C=O)-OH

<400>  6

Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Leu 
1               5                   10                  15      


Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu 
            20                  25                  30  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  terminus is C(=O)-OH or C(=O)NH2

<400>  7

Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg 
1               5                   10                  15      


Lys Arg Leu Leu 
            20  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  acetylated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = norleucine

<400>  8

Val Lys Phe Asn Lys Pro Phe Val Phe Leu Xaa Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  9

Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Cys optionally absent, when present terminus is C(=O)-OH or 
       C(=O)-NH2

<400>  10

Thr Phe Phe Tyr Gly Gly Cys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr Cys 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Cys optionally absent, when present terminus is C(=O)-OH or 
       C(=O)-NH2

<400>  11

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Arg Arg Asn Asn Phe Arg Thr 
1               5                   10                  15      


Glu Glu Tyr Cys 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Cys optionally absent, when present terminus is C(=O)-OH or 
       C(=O)-NH2

<400>  12

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Arg Arg Asn Asn Phe Arg Thr 
1               5                   10                  15      


Glu Glu Tyr Cys 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Cys optionally absent, when present terminus is C(=O)-OH or 
       C(=O)-NH2

<400>  13

Cys Tyr Glu Glu Thr Lys Phe Asn Asn Arg Lys Gly Arg Ser Gly Gly 
1               5                   10                  15      


Tyr Phe Phe Thr 
            20  


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  14

Thr Phe Phe Tyr Gly Gly Cys Arg Ala Lys Arg Asn Asn Phe Lys Arg 
1               5                   10                  15      


Ala Lys Tyr 
            


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  15

Thr Phe Phe Tyr Gly Gly Cys Arg Gly Lys Lys Asn Asn Phe Lys Arg 
1               5                   10                  15      


Ala Lys Tyr 
            


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  16

Pro Phe Phe Tyr Gly Gly Cys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  17

Thr Phe Phe Tyr Gly Gly Lys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Lys Glu Tyr 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  18

Thr Phe Phe Tyr Gly Gly Cys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Lys Arg Tyr 
            


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  19

Thr Phe Phe Tyr Gly Gly Lys Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Ala Glu Tyr 
            


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  20

Thr Phe Phe Tyr Gly Gly Lys Arg Gly Lys Arg Asn Asn Phe Lys Arg 
1               5                   10                  15      


Glu Lys Tyr 
            


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  21

Arg Phe Lys Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Phe Leu Arg 
1               5                   10                  15      


Leu Lys Tyr 
            


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  22

Arg Phe Lys Tyr Gly Gly Cys Leu Gly Asn Lys Asn Asn Tyr Leu Arg 
1               5                   10                  15      


Leu Lys Tyr 
            


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  23

Ser Val Trp Ile Trp Tyr Glu 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  24

Asp Val Trp Ile Ile Asn Lys Lys Leu Lys 
1               5                   10  


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  terminus is C(=O)-OH or C(=O)NH2

<400>  25

Met Leu Arg Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser 
            


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  terminus is C(=O)-OH or C(=O)-NH2

<400>  26

Met Leu Arg Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Lys Lys Arg Pro Lys Pro 
            20                  25  


<210>  27
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  terminus is C(=O)-OH or C(=O)-NH2

<400>  27

Met Leu Arg Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Lys Lys Leu Val Phe Phe 
            20                  25  


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  sequence repeats 1, 2, 3, 4, 5, or 6 times

<400>  28

Gly Gly Gly Gly Ser 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  sequence repeats 1, 2, 3, 4, 5, or 6 times

<400>  29

Ser Ser Ser Ser Gly 
1               5   


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment

<400>  30

Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10              


