                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       CASELLAS, Rafael
       XU, Jianliang
 
<120>  SINGLE DOMAIN ANTIBODIES THAT NEUTRALIZE SARS-COV-2

<130>  3000093-005977

<150>  US 63/151,530
<151>  2021-02-19

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb15)

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Leu Pro Phe Ser Asp Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val 
        35                  40                  45              


Ala Ala Ile Ser Gln Asn Gly Gly His Thr Tyr Ala Asp Ser Val Leu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Met Leu Thr Pro Gly Asp Thr Ala Val Tyr Ser Cys Ala 
                85                  90                  95      


Ala Arg Arg Pro Gly Gly Gly Arg Trp Asp Ala Ala His Asp Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb17)

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Ile Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Ser Ala Asp Thr Ala Gln Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Pro Thr Thr Leu Glu Tyr Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb19)

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Gly His Lys Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Val Gly Lys Asn Thr Val Glu Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Cys Asn 
                85                  90                  95      


Thr Ile Val Thr Met Thr Gly Val Pro Asp Ala Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb56)

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Arg Thr Phe Arg Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asp Arg Ser His Thr Lys Thr Gly Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asn Tyr Glu Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Ser Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr Asp 
            100                 105                 110         


Arg Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  5
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb6)

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Ala Asn Ser Asn 
            20                  25                  30          


Ser Met Ala Trp Trp Arg Gln Thr Pro Gly Asn Gln His Glu Arg Val 
        35                  40                  45              


Ala Ile Ile Ser His Gly Val Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Tyr Ala 
                85                  90                  95      


Asp Leu Phe Gly Asn Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  6
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb7)

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Ser Ser Glu Arg Thr Phe Arg Arg Tyr 
            20                  25                  30          


Gly Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asp Arg Ser His Ser Gln Thr Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Thr Val Tyr Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ser Tyr Glu Lys Gly Ser Asp Tyr Thr Ser Trp Asn Thr 
            100                 105                 110         


Asp Arg Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  7
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb43)

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Asn Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Ser Arg Trp Asp Tyr Ser Leu Thr Tyr His Tyr Thr 
            100                 105                 110         


Arg Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  8
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb47)

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Arg Tyr 
            20                  25                  30          


Ser Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Arg Trp Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gln Arg Phe Thr Ile Ser Gln Asp Asn Val Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Ser Arg Ser Asp His Tyr Leu Asn Ala Val Ala Trp Thr 
            100                 105                 110         


Leu Pro Asn Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb50)

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asp Gly Thr 
            20                  25                  30          


Tyr Arg Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Ile Gly Phe Gly Val Ser Thr Thr Ser Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Arg Pro Pro Pro Tyr Thr Glu Tyr Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb53)

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Leu Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Asn Trp Asn Gly Arg Val Pro Tyr Thr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Asn Tyr Gly Thr Gly Gly Ala Glu Thr Val Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb55)

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Ala Phe Ser Asp Ser 
            20                  25                  30          


Ser Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Val Ala Ala Leu Asn Arg Val Asn Val Ala Tyr Cys Arg Asp Ser Val 
    50                  55                  60                  


Ser Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Val Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Leu Ile Leu Asn Asp Cys Ser Arg Asn Pro Ala Arg Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  12
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (Nb60)

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Ala Ser Glu Arg Thr Phe Arg Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Arg Ser His Ser Asn Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Val Tyr Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Thr Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr 
            100                 105                 110         


Asp Arg Gly Tyr Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (msNb12)

<400>  13

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ile Cys Thr Ala Pro Gly Leu Thr His Asn Asn Cys 
            20                  25                  30          


Gly Leu Asp Trp Tyr Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Asp Gly Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Lys Val Glu Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Ser Cys Lys 
                85                  90                  95      


Thr Ala Phe Pro Tyr Phe Gly Asn Ser Cys Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (mNb30)

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Ala Ser Ser 
        115                 120     


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody sequence (mNb35)

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  17
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  18
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  19
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu 
            20                  25      


<210>  20
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Ser Ser Glu 
            20                  25      


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  23
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly 
            20                  25      


<210>  24
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Ala Ser Glu 
            20                  25      


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  25

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ile Cys Thr Ala Pro Gly 
            20                  25      


<210>  26
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 sequence

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  27

Leu Pro Phe Ser Asp Tyr Leu Met Gly 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  28

Arg Thr Phe Gly Ile Tyr Arg Met Gly 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  29

Ser Gly Phe Ser Ile His Ala Met Gly 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  30

Arg Thr Phe Arg Arg Tyr Gly Met Gly 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  31

Asn Ile Ala Asn Ser Asn Ser Met Ala 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  32

Arg Thr Phe Arg Arg Tyr Gly Ile Ala 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  33

Arg Thr Phe Ser Asp Ser Ala Met Gly 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  34

Arg Thr Leu Ser Arg Tyr Ser Met Ser 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  35

Arg Thr Phe Asp Gly Thr Tyr Arg Met Gly 
1               5                   10  


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  36

Leu Thr Phe Ser Ser Tyr Leu Met Ala 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  37

Arg Ala Phe Ser Asp Ser Ser Ala Met Ala 
1               5                   10  


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  38

Leu Thr His Asn Asn Cys Gly Leu Asp 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  39

Leu Thr Phe Ser Lys Tyr Ala Met Gly 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 sequence

<400>  40

Arg Thr Phe Ser Lys Tyr Ala Met Gly 
1               5                   


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  41

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val Ala 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  42

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  43

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  44

Trp Trp Arg Gln Thr Pro Gly Asn Gln His Glu Arg Val Ala 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  45

Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  46

Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  47

Trp Tyr Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  48

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val Ala 
1               5                   10                  


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  49

Ala Ile Ser Gln Asn Gly Gly His Thr 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  50

Ala Ile Thr Ser Ser Ala Asp Thr Ala Gln 
1               5                   10  


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  51

Val Val Gly His Lys Thr Asn 
1               5           


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  52

Ala Val Asp Arg Ser His Thr Lys Thr Gly 
1               5                   10  


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  53

Ile Ile Ser His Gly Val Thr Asn 
1               5               


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  54

Ala Val Asp Arg Ser His Ser Gln Thr Asn 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  55

Val Ile Thr Trp Asn Gly Gly Thr Thr Tyr 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  56

Gly Ile Arg Trp Ser Gly Ser Asn Thr Tyr 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 sequence

<400>  57

Ala Ile Gly Phe Gly Val Ser Thr Thr Ser 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  58

Arg Ile Asn Trp Asn Gly Arg Val Pro Tyr 
1               5                   10  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  59

Ala Leu Asn Arg Val Asn Val Ala Tyr 
1               5                   


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  60

Ala Ile Asp Arg Ser His Ser Asn Thr Asp 
1               5                   10  


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  61

Ser Ile Ser Ala Asp Gly Thr Thr Ser 
1               5                   


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 sequence

<400>  62

Thr Ile Ser Trp Ser Gly Asp Ser Ala Phe 
1               5                   10  


<210>  63
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  63

Tyr Ala Asp Ser Val Leu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Met Leu Thr Pro Gly Asp Thr 
            20                  25                  30          


Ala Val Tyr Ser Cys 
        35          


<210>  64
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  64

Tyr Arg Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Tyr Cys 
        35          


<210>  65
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  65

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Gly 
1               5                   10                  15      


Lys Asn Thr Val Glu Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  66
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  66

Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Thr Asn Tyr Glu 
1               5                   10                  15      


Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  67
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  67

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ala Tyr Tyr Cys 
        35          


<210>  68
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  68

Tyr Ala Asp Phe Val Gln Gly Arg Phe Thr Ile Ser Thr Val Tyr Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  69
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  69

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  70
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  70

Tyr Ala Asp Ser Met Lys Gln Arg Phe Thr Ile Ser Gln Asp Asn Val 
1               5                   10                  15      


Lys Asn Thr Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  71
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  71

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  72
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  72

Thr Val Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Trp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  73
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  73

Cys Arg Asp Ser Val Ser Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
1               5                   10                  15      


Lys Asn Thr Ala Tyr Leu Glu Met Asn Ser Val Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Tyr Cys 
        35          


<210>  74
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  74

Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Thr Val Tyr Ala 
1               5                   10                  15      


Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  75
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  75

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Lys Val 
1               5                   10                  15      


Glu Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Ile Tyr Ser Cys 
        35          


<210>  76
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 sequence

<400>  76

Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  77

Ala Ala Arg Arg Pro Gly Gly Gly Arg Trp Asp Ala Ala His Asp Tyr 
1               5                   10                  15      


Asn 
    


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  78

Ala Ala Arg Asp Pro Thr Thr Leu Glu Tyr Gly 
1               5                   10      


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  79

Tyr Cys Asn Thr Ile Val Thr Met Thr Gly Val Pro Asp Ala 
1               5                   10                  


<210>  80
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  80

Ala Ala Pro Ser Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr 
1               5                   10                  15      


Asp Arg Gly Tyr Asp 
            20      


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  81

Tyr Ala Asp Leu Phe Gly Asn Thr 
1               5               


<210>  82
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  82

Ala Ala Ala Ser Tyr Glu Lys Gly Ser Asp Tyr Thr Ser Trp Asn Thr 
1               5                   10                  15      


Asp Arg Gly Tyr Asp 
            20      


<210>  83
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  83

Ala Ala Asp Thr Ser Arg Trp Asp Tyr Ser Leu Thr Tyr His Tyr Thr 
1               5                   10                  15      


Arg Glu Tyr Asn 
            20  


<210>  84
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  84

Ala Ala Thr Ser Arg Ser Asp His Tyr Leu Asn Ala Val Ala Trp Thr 
1               5                   10                  15      


Leu Pro Asn Glu Tyr Asp 
            20          


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  85

Ala Ala Arg Pro Pro Pro Tyr Thr Glu Tyr Asn 
1               5                   10      


<210>  86
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  86

Ala Ala Asp Arg Asn Tyr Gly Thr Gly Gly Ala Glu Thr Val Tyr Glu 
1               5                   10                  15      


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  87

Ala Ser Asp Leu Ile Leu Asn Asp Cys Ser Arg Asn Pro Ala Arg Tyr 
1               5                   10                  15      


Ala 
    


<210>  88
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  88

Ala Ala Ala Thr Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr 
1               5                   10                  15      


Asp Arg Gly Tyr Asp 
            20      


<210>  89
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  89

Lys Thr Ala Phe Pro Tyr Phe Gly Asn Ser Cys Val Leu Asp 
1               5                   10                  


<210>  90
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  90

Ala Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp 
1               5                   10              


<210>  91
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence

<400>  91

Thr Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp 
1               5                   10              


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 sequence

<400>  92

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 sequence

<400>  93

Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 sequence

<400>  94

Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 sequence

<400>  95

Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 sequence

<400>  96

Tyr Trp Gly Gln Gly Thr Ser Val Thr Ala Ser Ser 
1               5                   10          


<210>  97
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb15)

<400>  97
caggtgcagc tgcaggagtc tgggggaggg ttggtgcagg ctgggggctc tctgagagtc       60

tcctgtgcag cgtctggact tcccttcagt gactatttaa tgggctggtt ccgccaggcg      120

ccagggaagg agcgtgagta tgtagccgct attagtcaga atggtggaca cacttatgca      180

gactccgtgc tgggccgatt caccatctcc agagacaacg ccaagaatac ggtgtatctg      240

caaatgaaca tgttgacacc tggggacacg gccgtttata gttgtgctgc ccgaaggccc      300

ggtgggggta ggtgggatgc cgcccatgac tataactact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  98
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb17)

<400>  98
caggtgcagc tgcaggagtc tgggggagga ttggtgcaaa ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttcggt atctatcgca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct atcacttcga gtgctgatac cgcacagtat      180

cgagactccg tgaagggccg attcgccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccattt attattgtgc agcacgggat      300

cccactacat tggagtatgg caactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  99
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb19)

<400>  99
caggtgcagc tgcaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactg       60

tcctgtgcag cctctggaag cggctttagt attcatgcca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt cgtcgctgtc gttggccata agacgaacta tgcagactcc      180

gttaagggcc gattcaccat ctccagagac gttggcaaga acacggtgga gctgcaaatg      240

aacagcctga aagttgagga cacagccgtc tattattgtt actgcaatac tatcgtgact      300

atgacagggg ttcctgatgc cgtctggggc caggggaccc aggtcaccgt ctcctca         357


<210>  100
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb56)

<400>  100
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctggggactc tctgagactc       60

tcctgtgtag cctctgaacg cacattcagg cgctatggca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct gttgaccgga gtcatactaa gacaggctat      180

gcagacttcg tgaagggccg attcaccatc tccacgaact acgagaacat ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtttatt actgtgctgc gccgtcgtac      300

gagaaagggt cggaccctac tagttggaac accgacagag ggtatgacta ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  101
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb6)

<400>  101
caggtgcagc tgcaggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaaa catcgcgaat tccaattcca tggcctggtg gcgccagact      120

ccaggaaacc agcacgagcg ggtcgccatt attagtcatg gtgtaacaaa ctatgcagat      180

tccgtgaagg gccgattcac agtgtccaga gacaacgcca agaatacttt gtatctgcaa      240

atgaacaacc tgaaacctga ggacacagcc gcctattatt gttatgcaga tctcttcgga      300

aacacctact ggggccaggg gacccaggtc accgtctcct ca                         342


<210>  102
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb7)

<400>  102
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctggggactc tctgagactc       60

tcctgtctat cctctgaacg cacattcagg cgctatggca tagcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct gttgaccgga gtcatagtca gacaaactat      180

gcagacttcg tacagggccg attcaccatc tccacggtct acgccaagaa catggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc tgcggcgtcg      300

tacgagaaag ggtcggacta tactagttgg aacaccgaca gagggtatga ctactggggc      360

caggggaccc aggtcaccgt ctcctca                                          387


<210>  103
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb43)

<400>  103
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctggggactc tctgaaactc       60

tcctgtgcag cctctggacg caccttcagt gacagtgcca tgggctggtt ccgccaggct      120

ccaggagagg agcgtgagtt tgtagcagtt attacctgga atggtggcac cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagacg acgccaagaa cacggtgtac      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcggacaca      300

agccggtggg actatagtct tacataccac tacacgaggg agtataacta ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  104
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb47)

<400>  104
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttgagt aggtattcca tgagctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcaggt atacggtgga gtggtagtaa cacatactat      180

gcagactcca tgaagcagcg attcaccatc tcccaagaca atgtcaagaa cacggtgcat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agccacaagt      300

agaagtgatc attacttgaa tgccgtggct tggacccttc cgaatgagta tgactactgg      360

ggccagggga cccaggtcac cgtctcctca                                       390


<210>  105
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb50)

<400>  105
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggatc tctgagactc       60

tcctgtgcag cctctggacg caccttcgat ggtacctatc gcatgggctg gttccgccag      120

ggtccaggga aggagcgtga gtttgtagca gctataggct tcggtgttag taccacatcg      180

tatgcagact ccgtgaaggg ccgattcacc atctccagaa acaacgccaa gaacacggtg      240

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg cgcagcgcgc      300

cccccgcctt acacggagta taactactgg ggccagggga cccaggtcac cgtctcctca      360


<210>  106
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb53)

<400>  106
caggtgcagc tgcaggagtc tggaggagga gtggtgcagg ctggggactc tctgagactc       60

tcctgtgcag cctctggact caccttcagt agttatctca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcacgt attaactgga atggtcgtgt gccatacact      180

gtagactctg tgaagggccg attcatcatc tccagagaca atgccaaaaa cacggtgtgg      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcagaccgg      300

aactacggca cagggggcgc cgaaacagtg tatgagtact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  107
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb55)

<400>  107
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgaag cctctggacg cgccttcagt gactcgtcgg ccatggcctg gttccgccag      120

gctccaggga aggagcgtga gtttgtagcg gcgcttaaca gagttaatgt tgcatattgt      180

agagactccg tgtcgggccg attcaccatc tccagagaca acggcaagaa tacggcatat      240

ctggaaatga acagtgtgaa acctgaggac acggccattt attactgtgc atcagatcta      300

atcctaaatg attgcagtcg aaaccccgcg aggtatgcct actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  108
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (Nb60)

<400>  108
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctggggactc tctgagactc       60

tcctgtctag cctctgaacg cacattcagg cgctatggca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attgaccgga gtcatagtaa tacagactat      180

gcagacttcg tgaagggccg attcaccatc tccacggtct acgccaagaa catggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc tgcggcgacg      300

tacgagaaag ggtcggaccc tactagttgg aacaccgaca gagggtatga cgtctggggc      360

caggggaccc aggtcaccgt ctcctca                                          387


<210>  109
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (msNb12)

<400>  109
caagtaaaac ttgaagaatc aggtggtgga agcgttcaag ctggtggatc tctcagactt       60

atttgtaccg cacccggctt aacacataat aactgtggct tggactggta cagacgagca      120

ccaggcaagg aacgcgagtt cgtttcatca ataagtgcag atggaaccac ttcatacgca      180

gattccgtca agggacggtt taccattagt aaggacaaag tcgaggacac agtctacctc      240

caaatgaaca gtttgaagcc agaagacact gctatttatt catgcaagac agccttccct      300

tacttcggta atagctgtgt tttggactac tggggtcaag gaacctcagt caccgtctcc      360

tcg                                                                    363


<210>  110
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (mNb30)

<400>  110
caggtgcaat tggtagagtc tggcggtgga ctcgttcaag ccggaggctc actgcggttg       60

tcttgtgccg catctggtct aaccttctca aaatatgcta tggggtggtt ccggcaggct      120

ccaggtaaag agcggaaatt tgtcgcaaca attagttggt ctggtgatag tgccttctat      180

gctgattcag taaaaggtcg attcactata tcacgggata acgcaagaaa tactgtctat      240

ctccaaatga actctctgaa gcctgaagat actgctgtgt attactgtgc cgcagatcga      300

ggaatggggt atggggattt tatggactac tggggtcaag gaacctcagt caccgcctcc      360

tcggcctcag gggcc                                                       375


<210>  111
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single-domain antibody nt sequence (mNb35)

<400>  111
caggtccaac tggtagagtc aggcggtgga ctcgttcaag ccggaggctc actgcggttg       60

tcttgtgccg catctggtcg aaccttctca aaatatgcta tggggtggtt ccggcaggct      120

ccaggtaaag agcggaaatt tgtcgcaaca attagttggt ctggtgatag tgccttctat      180

gctgattcag taaaaggtcg attcactata tcacgggata acgcaagaaa tactgtctat      240

ctccaaatga actctctgaa gcctgaagat actgctgtgt attactgtac cgcagatcga      300

ggaatggggt atggggattt tatggactac tggggtcaag gtacctcagt caccgtctcc      360

tcggcctcag gggcc                                                       375


<210>  112
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb15-IgG1

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Leu Pro Phe Ser Asp Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val 
        35                  40                  45              


Ala Ala Ile Ser Gln Asn Gly Gly His Thr Tyr Ala Asp Ser Val Leu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Met Leu Thr Pro Gly Asp Thr Ala Val Tyr Ser Cys Ala 
                85                  90                  95      


Ala Arg Arg Pro Gly Gly Gly Arg Trp Asp Ala Ala His Asp Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Trp Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Trp Ser Val Leu 
        195                 200                 205             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    210                 215                 220                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
225                 230                 235                 240 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                245                 250                 255     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            260                 265                 270         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        275                 280                 285             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    290                 295                 300                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 


<210>  113
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb17-IgG1

<400>  113

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Ile Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Ser Ala Asp Thr Ala Gln Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Pro Thr Thr Leu Glu Tyr Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Trp Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                165                 170                 175     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            180                 185                 190         


Gln Tyr Asn Ser Thr Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    210                 215                 220                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
225                 230                 235                 240 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                245                 250                 255     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            260                 265                 270         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        275                 280                 285             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    290                 295                 300                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
305                 310                 315                 320 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                325                 330                 335     


Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 


<210>  114
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb19-IgG1

<400>  114

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Gly His Lys Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Val Gly Lys Asn Thr Val Glu Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Cys Asn 
                85                  90                  95      


Thr Ile Val Thr Met Thr Gly Val Pro Asp Ala Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Trp Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                165                 170                 175     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            180                 185                 190         


Gln Tyr Asn Ser Thr Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    210                 215                 220                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
225                 230                 235                 240 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                245                 250                 255     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            260                 265                 270         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        275                 280                 285             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    290                 295                 300                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
305                 310                 315                 320 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                325                 330                 335     


Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 


<210>  115
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb56-IgG1

<400>  115

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Arg Thr Phe Arg Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asp Arg Ser His Thr Lys Thr Gly Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asn Tyr Glu Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Ser Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr Asp 
            100                 105                 110         


Arg Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  116
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  msNb12-IgG2a

<400>  116

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ile Cys Thr Ala Pro Gly Leu Thr His Asn Asn Cys 
            20                  25                  30          


Gly Leu Asp Trp Tyr Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Asp Gly Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Lys Val Glu Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Ser Cys Lys 
                85                  90                  95      


Thr Ala Phe Pro Tyr Phe Gly Asn Ser Cys Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Glu Pro Lys Ile Pro Gln Pro 
        115                 120                 125             


Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro 
    130                 135                 140                 


Lys Pro Glu Pro Glu Cys Thr Cys Pro Lys Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  117
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mNb30-IgG2a

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Ala Ser Ser Glu Pro Lys Ile Pro Gln Pro 
        115                 120                 125             


Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro 
    130                 135                 140                 


Lys Pro Glu Pro Glu Cys Thr Cys Pro Lys Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  118
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb15-tri-IgG1

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Leu Pro Phe Ser Asp Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val 
        35                  40                  45              


Ala Ala Ile Ser Gln Asn Gly Gly His Thr Tyr Ala Asp Ser Val Leu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Met Leu Thr Pro Gly Asp Thr Ala Val Tyr Ser Cys Ala 
                85                  90                  95      


Ala Arg Arg Pro Gly Gly Gly Arg Trp Asp Ala Ala His Asp Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Val Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Leu Pro Phe Ser Asp Tyr Leu Met Gly Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val Ala Ala Ile Ser Gln 
            180                 185                 190         


Asn Gly Gly His Thr Tyr Ala Asp Ser Val Leu Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Met Leu 
    210                 215                 220                 


Thr Pro Gly Asp Thr Ala Val Tyr Ser Cys Ala Ala Arg Arg Pro Gly 
225                 230                 235                 240 


Gly Gly Arg Trp Asp Ala Ala His Asp Tyr Asn Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Ala Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Leu Pro Phe Ser Asp Tyr Leu Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Glu Arg Glu Tyr Val Ala Ala Ile Ser Gln Asn Gly Gly His Thr 
                325                 330                 335     


Tyr Ala Asp Ser Val Leu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Val Tyr Leu Gln Met Asn Met Leu Thr Pro Gly Asp Thr 
        355                 360                 365             


Ala Val Tyr Ser Cys Ala Ala Arg Arg Pro Gly Gly Gly Arg Trp Asp 
    370                 375                 380                 


Ala Ala His Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                405                 410                 415     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            420                 425                 430         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser 
        435                 440                 445             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    450                 455                 460                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
465                 470                 475                 480 


Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                485                 490                 495     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            500                 505                 510         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        515                 520                 525             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    530                 535                 540                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
545                 550                 555                 560 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                565                 570                 575     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            580                 585                 590         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        595                 600                 605             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    610                 615                 620                 


Pro Gly Lys 
625         


<210>  119
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb17-tri-IgG1

<400>  119

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Ile Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Ser Ala Asp Thr Ala Gln Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Pro Thr Thr Leu Glu Tyr Gly Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Arg Thr Phe Gly Ile Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Thr Ser Ser Ala Asp Thr Ala 
            180                 185                 190         


Gln Tyr Arg Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Ile Tyr Tyr Cys Ala Ala Arg Asp Pro Thr Thr Leu Glu Tyr 
225                 230                 235                 240 


Gly Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            260                 265                 270         


Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Ile Tyr Arg Met Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Thr 
305                 310                 315                 320 


Ser Ser Ala Asp Thr Ala Gln Tyr Arg Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Arg Asp 
        355                 360                 365             


Pro Thr Thr Leu Glu Tyr Gly Asn Trp Gly Gln Gly Thr Gln Val Thr 
    370                 375                 380                 


Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
385                 390                 395                 400 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                405                 410                 415     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val 
            420                 425                 430         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        435                 440                 445             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    450                 455                 460                 


Thr Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210>  120
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb19-tri-IgG1

<400>  120

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Gly His Lys Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Val Gly Lys Asn Thr Val Glu Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Cys Asn 
                85                  90                  95      


Thr Ile Val Thr Met Thr Gly Val Pro Asp Ala Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Ser Gly Phe Ser Ile His Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gln Arg Glu Phe Val Ala Val Val Gly His Lys Thr Asn Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Gly Lys Asn 
        195                 200                 205             


Thr Val Glu Leu Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Tyr Cys Asn Thr Ile Val Thr Met Thr Gly Val Pro Asp 
225                 230                 235                 240 


Ala Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            260                 265                 270         


Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Ile His Ala Met Gly Trp 
    290                 295                 300                 


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Val Val Gly 
305                 310                 315                 320 


His Lys Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Val Gly Lys Asn Thr Val Glu Leu Gln Met Asn Ser Leu Lys 
            340                 345                 350         


Val Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Cys Asn Thr Ile Val Thr 
        355                 360                 365             


Met Thr Gly Val Pro Asp Ala Val Trp Gly Gln Gly Thr Gln Val Thr 
    370                 375                 380                 


Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
385                 390                 395                 400 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                405                 410                 415     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val 
            420                 425                 430         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        435                 440                 445             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    450                 455                 460                 


Thr Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
465                 470                 475                 480 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                485                 490                 495     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            500                 505                 510         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        515                 520                 525             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    530                 535                 540                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
545                 550                 555                 560 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                565                 570                 575     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            580                 585                 590         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        595                 600                 605             


Ser Pro Gly Lys 
    610         


<210>  121
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nb56-tri-IgG1

<400>  121

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Arg Thr Phe Arg Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asp Arg Ser His Thr Lys Thr Gly Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asn Tyr Glu Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Pro Ser Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr Asp 
            100                 105                 110         


Arg Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Val Ala Ser Glu Arg Thr Phe Arg Arg Tyr Gly 
                165                 170                 175     


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
            180                 185                 190         


Ala Val Asp Arg Ser His Thr Lys Thr Gly Tyr Ala Asp Phe Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Thr Asn Tyr Glu Asn Met Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
225                 230                 235                 240 


Pro Ser Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr Asp Arg 
                245                 250                 255     


Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Val Ala Ser Glu Arg Thr Phe Arg Arg Tyr Gly Met 
305                 310                 315                 320 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
                325                 330                 335     


Val Asp Arg Ser His Thr Lys Thr Gly Tyr Ala Asp Phe Val Lys Gly 
            340                 345                 350         


Arg Phe Thr Ile Ser Thr Asn Tyr Glu Asn Met Val Tyr Leu Gln Met 
        355                 360                 365             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Pro 
    370                 375                 380                 


Ser Tyr Glu Lys Gly Ser Asp Pro Thr Ser Trp Asn Thr Asp Arg Gly 
385                 390                 395                 400 


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Lys 
                405                 410                 415     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            420                 425                 430         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        435                 440                 445             


Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser His Glu Asp Pro 
    450                 455                 460                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
465                 470                 475                 480 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Trp Ser 
                485                 490                 495     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            500                 505                 510         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        515                 520                 525             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    530                 535                 540                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
545                 550                 555                 560 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                565                 570                 575     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            580                 585                 590         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        595                 600                 605             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    610                 615                 620                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 635                 


<210>  122
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  msNb12-tri-IgG2a

<400>  122

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ile Cys Thr Ala Pro Gly Leu Thr His Asn Asn Cys 
            20                  25                  30          


Gly Leu Asp Trp Tyr Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Asp Gly Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Lys Val Glu Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Ser Cys Lys 
                85                  90                  95      


Thr Ala Phe Pro Tyr Phe Gly Asn Ser Cys Val Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly 
    130                 135                 140                 


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ile Cys Thr Ala 
145                 150                 155                 160 


Pro Gly Leu Thr His Asn Asn Cys Gly Leu Asp Trp Tyr Arg Arg Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Ser Ala Asp Gly Thr 
            180                 185                 190         


Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp 
        195                 200                 205             


Lys Val Glu Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Ala Ile Tyr Ser Cys Lys Thr Ala Phe Pro Tyr Phe Gly Asn 
225                 230                 235                 240 


Ser Cys Val Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ile Cys Thr Ala Pro Gly Leu Thr His Asn Asn Cys 
    290                 295                 300                 


Gly Leu Asp Trp Tyr Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
305                 310                 315                 320 


Ser Ser Ile Ser Ala Asp Gly Thr Thr Ser Tyr Ala Asp Ser Val Lys 
                325                 330                 335     


Gly Arg Phe Thr Ile Ser Lys Asp Lys Val Glu Asp Thr Val Tyr Leu 
            340                 345                 350         


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Ser Cys Lys 
        355                 360                 365             


Thr Ala Phe Pro Tyr Phe Gly Asn Ser Cys Val Leu Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Ser Val Thr Val Ser Ser Glu Pro Lys Ile Pro Gln Pro 
385                 390                 395                 400 


Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro 
                405                 410                 415     


Lys Pro Glu Pro Glu Cys Thr Cys Pro Lys Cys Pro Ala Pro Glu Leu 
            420                 425                 430         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        435                 440                 445             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser 
    450                 455                 460                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
465                 470                 475                 480 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                485                 490                 495     


Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            500                 505                 510         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        515                 520                 525             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    530                 535                 540                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
545                 550                 555                 560 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                565                 570                 575     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            580                 585                 590         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        595                 600                 605             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    610                 615                 620                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
625                 630                 635                 640 


Pro Gly Lys 
            


<210>  123
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mNb30-tri-IgG2a

<400>  123

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Ala Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Leu Thr Phe Ser Lys Tyr Ala Met Gly Trp Phe Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Glu Arg Lys Phe Val Ala Thr Ile Ser Trp Ser Gly Asp 
            180                 185                 190         


Ser Ala Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg Gly Met Gly Tyr 
225                 230                 235                 240 


Gly Asp Phe Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Ala Ser 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
        275                 280                 285             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Lys Tyr 
    290                 295                 300                 


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val 
305                 310                 315                 320 


Ala Thr Ile Ser Trp Ser Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
            340                 345                 350         


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Ala Asp Arg Gly Met Gly Tyr Gly Asp Phe Met Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Ser Val Thr Ala Ser Ser Glu Pro Lys Ile Pro Gln Pro 
385                 390                 395                 400 


Gln Pro Lys Pro Gln Pro Gln Pro Gln Pro Gln Pro Lys Pro Gln Pro 
                405                 410                 415     


Lys Pro Glu Pro Glu Cys Thr Cys Pro Lys Cys Pro Ala Pro Glu Leu 
            420                 425                 430         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        435                 440                 445             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Trp Asp Val Ser 
    450                 455                 460                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
465                 470                 475                 480 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                485                 490                 495     


Tyr Arg Trp Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            500                 505                 510         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        515                 520                 525             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    530                 535                 540                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
545                 550                 555                 560 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                565                 570                 575     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            580                 585                 590         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        595                 600                 605             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    610                 615                 620                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
625                 630                 635                 640 


Pro Gly Lys 
            


<210>  124
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein [Severe acute respiratory syndrome coronavirus
       2]

<400>  124

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val 
        


<210>  125
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein S [SARS coronavirus BJ01]

<400>  125

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
1               5                   10                  15      


Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp 
            100                 105                 110         


Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
        115                 120                 125             


Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser 
    130                 135                 140                 


Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro 
145                 150                 155                 160 


Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro 
                165                 170                 175     


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
            180                 185                 190         


Val 
    


<210>  126
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein [MERS coronavirus]

<400>  126

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu 
    210         


<210>  127
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS CoV-2 spike receptor-binding domain

<400>  127

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  128
<211>  1253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein [Severe acute respiratory syndrome coronavirus
       2]

<400>  128

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Ala Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Ser Gly  Arg Leu Val 
    1205                 1210                 1215             


Pro Arg  Gly Ser Pro Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg 
    1220                 1225                 1230             


Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu 
    1235                 1240                 1245             


Ser Thr  Phe Leu Gly 
    1250             


<210>  129
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RBD polypeptide

<400>  129

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Arg Val 
1               5                   10                  15      


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
            20                  25                  30          


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
        35                  40                  45              


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
    50                  55                  60                  


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
65                  70                  75                  80  


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
                85                  90                  95      


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
            100                 105                 110         


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
        115                 120                 125             


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
    130                 135                 140                 


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
145                 150                 155                 160 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
                165                 170                 175     


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
            180                 185                 190         


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
        195                 200                 205             


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
    210                 215                 220                 


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe His His His 
225                 230                 235                 240 


His His His 
            


<210>  130
<211>  1256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Spike polypeptide

<400>  130

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ala Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Ser Gly Arg Leu Val  Pro Arg Gly 
    1205                 1210                 1215             


Ser Pro  Gly Ser Gly Tyr Ile  Pro Glu Ala Pro Arg  Asp Gly Gln 
    1220                 1225                 1230             


Ala Tyr  Val Arg Lys Asp Gly  Glu Trp Val Leu Leu  Ser Thr Phe 
    1235                 1240                 1245             


Leu Gly  His His His His His  His 
    1250                 1255     


