                         SEQUENCE LISTING

<110>  Theripion, Inc.
       Ledbetter, Jeffrey A.
       Hayden-Ledbetter, Martha S.
 
<120>  Paraoxonase Fusion Polypeptides and Related Compositions and 
       Methods

<130>  TRP-0410PC

<150>  US 63/151,236
<151>  2021-02-19

<150>  US 63/151,272
<151>  2021-02-19

<160>  164   

<170>  PatentIn version 3.5

<210>  1
<211>  2688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA


<220>
<221>  sig_peptide
<222>  (1)..(60)
<223>  human VK3 leader peptide

<220>
<221>  misc_feature
<222>  (61)..(840)
<223>  human DNase 1 (N74K, G105R, A114F) without leader peptide

<220>
<221>  misc_feature
<222>  (280)..(283)
<223>  human DNase 1 N74K substitution

<220>
<221>  misc_feature
<222>  (373)..(375)
<223>  human DNase 1 G105R substitution

<220>
<221>  misc_feature
<222>  (399)..(401)
<223>  human DNase 1 A114F substitution

<220>
<221>  misc_feature
<222>  (841)..(918)
<223>  (gly4ser)4 linker peptide sequence with additional restriction 
       site amino acids

<220>
<221>  misc_feature
<222>  (919)..(1614)
<223>  human IgG1 variant Fc (SSS hinge, P238S, P331S)

<220>
<221>  misc_feature
<222>  (931)..(933)
<223>  human IgG1 hinge C220S substitution

<220>
<221>  misc_feature
<222>  (949)..(951)
<223>  human IgG1 hinge C226S substitution

<220>
<221>  misc_feature
<222>  (958)..(960)
<223>  human IgG1 hinge C229S substitution

<220>
<221>  misc_feature
<222>  (985)..(987)
<223>  human IgG1 lower hinge-CH2 P238S substitution

<220>
<221>  misc_feature
<222>  (1264)..(1266)
<223>  human IgG1 Fc P331S substitution

<220>
<221>  misc_feature
<222>  (1615)..(1672)
<223>  peptide linker containing N-linked glycosylation site

<220>
<221>  misc_feature
<222>  (1673)..(2688)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  misc_feature
<222>  (2197)..(2199)
<223>  PON1 Q192K substitution

<400>  1
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttcta ccggtctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      960

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1320

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaagtcgac     1620

ggagctagca gccccgtgaa cgtgagcagc cccagcgtgc aggatatcct cttcaggaac     1680

caccagtctt cttaccaaac acgacttaat gctctccgag aggtacaacc cgtagaactt     1740

cctaactgta atttagttaa aggaatcgaa actggctctg aagacttgga gatactgcct     1800

aatggactgg ctttcattag ctctggatta aagtatcctg gaataaagag cttcaacccc     1860

aacagtcctg gaaaaatact tctgatggac ctgaatgaag aagatccaac agtgttggaa     1920

ttggggatca ctggaagtaa atttgatgta tcttcattta accctcatgg gattagcaca     1980

ttcacagatg aagataatgc catgtacctc ctggtggtga accatccaga tgccaagtcc     2040

acagtggagt tgtttaaatt tcaagaagaa gaaaaatcgc ttttgcatct aaaaaccatc     2100

agacataaac ttctgcctaa tttgaatgat attgttgctg tgggacctga gcacttttat     2160

ggcacaaatg atcactattt tcttgacccc tacttaaaat cctgggagat gtatttgggt     2220

ttagcgtggt cgtatgttgt ctactatagt ccaagtgaag ttcgagtggt ggcagaagga     2280

tttgattttg ctaatggaat caacatttca cccgatggca agtatgtcta tatagctgag     2340

ttgctggctc ataagattca tgtgtatgaa aagcatgcta attggacttt aactccattg     2400

aagtcccttg actttaatac cctcgtggat aacatatctg tggatcctga gacaggagac     2460

ctttgggttg gatgccatcc caatggcatg aaaatcttct tctatgactc agagaatcct     2520

cctgcatcag aggtgcttcg aatccagaac attctaacag aagaacctaa agtgacacag     2580

gtttatgcag aaaatggcac agtgttgcaa ggcagtacag ttgcctctgt gtacaaaggg     2640

aaactgctga ttggcacagt gtttcacaaa gctctttact gtgagctc                  2688


<210>  2
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 leader peptide

<220>
<221>  MISC_FEATURE
<222>  (21)..(280)
<223>  human DNase 1 (N74K, G105R, A114F) without leader peptide

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  human DNase 1 N74K substitution

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  human DNase 1 G105R substitution

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  human DNase 1 A114F substitution

<220>
<221>  MISC_FEATURE
<222>  (281)..(306)
<223>  (gly4ser)4 linker peptide with restriction site amino acids

<220>
<221>  MISC_FEATURE
<222>  (307)..(538)
<223>  human IgG1 variant Fc (SSS hinge, P238S, P331S)

<220>
<221>  MISC_FEATURE
<222>  (311)..(311)
<223>  human IgG1 C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (317)..(317)
<223>  human IgG1 C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (320)..(320)
<223>  human IgG1 C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (329)..(329)
<223>  P238S lower hinge-CH2 mutation

<220>
<221>  MISC_FEATURE
<222>  (422)..(422)
<223>  human IgG1 P331S substitution

<220>
<221>  MISC_FEATURE
<222>  (539)..(557)
<223>  peptide linker containing N-linked glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (558)..(896)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (733)..(733)
<223>  PON1 Q192K substitution

<400>  2

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn 
545                 550                 555                 560 


His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly 
            580                 585                 590         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val 
            660                 665                 670         


Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser 
            740                 745                 750         


Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile 
            820                 825                 830         


Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  3
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttacaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctc                     1065


<210>  4
<211>  355
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(16)
<223>  PON1 noncleaved signal peptide

<220>
<221>  mat_peptide
<222>  (1)..(355)
<223>  PON1 coding sequence

<220>
<221>  MISC_FEATURE
<222>  (17)..(355)
<223>  PON1 sequence without uncleaved leader sequence

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  PON1 sequence variant Q192

<400>  4

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  5
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PON1 Q192K DNA

<400>  5
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaaaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctc                     1065


<210>  6
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PON1 Q192K


<220>
<221>  SIGNAL
<222>  (1)..(16)
<223>  PON1 uncleaved leader sequence

<220>
<221>  mat_peptide
<222>  (1)..(355)
<223>  PON1 mature polypeptide with uncleaved leader

<220>
<221>  MISC_FEATURE
<222>  (17)..(355)
<223>  PON1 sequence without uncleaved signal peptide

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  PON1 mutant Q192K

<400>  6

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  7
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaagatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctc                     1065


<210>  8
<211>  355
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(16)
<223>  PON1 uncleaved signal peptide

<400>  8

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Arg 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  9
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (gly4ser)2 linker DNA

<400>  9
agatctctcc ggaggaggtg gctcaggtgg tggaggatct accggtctcg ag               52


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser)2 linker

<400>  10

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
1               5                   10                  15      


<210>  11
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (gly4ser)4 linker DNA

<400>  11
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct accggtctcg ag                                                82


<210>  12
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser)4 linker

<400>  12

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
            20                  25      


<210>  13
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (gly4ser)6 linker DNA

<400>  13
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct ggaggaggtg gtagtggagg tggaggttct accggtctcg ag              112


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser)6 linker

<400>  14

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Thr Gly Leu 
        35      


<210>  15
<211>  846
<212>  DNA
<213>  Homo sapiens

<400>  15
atgaggggca tgaagctgct gggggcgctg ctggcactgg cggccctact gcagggggcc       60

gtgtccctga agatcgcagc cttcaacatc cagacatttg gggagaccaa gatgtccaat      120

gccaccctcg tcagctacat tgtgcagatc ctgagccgct atgacatcgc cctggtccag      180

gaggtcagag acagccacct gactgccgtg gggaagctgc tggacaacct caatcaggat      240

gcaccagaca cctatcacta cgtggtcagt gagccactgg gacggaacag ctataaggag      300

cgctacctgt tcgtgtacag gcctgaccag gtgtctgcgg tggacagcta ctactacgat      360

gatggctgcg agccctgcgg gaacgacacc ttcaaccgag agccagccat tgtcaggttc      420

ttctcccggt tcacagaggt cagggagttt gccattgttc ccctgcatgc ggccccgggg      480

gacgcagtag ccgagatcga cgctctctat gacgtctacc tggatgtcca agagaaatgg      540

ggcttggagg acgtcatgtt gatgggcgac ttcaatgcgg gctgcagcta tgtgagaccc      600

tcccagtggt catccatccg cctgtggaca agccccacct tccagtggct gatccccgac      660

agcgctgaca ccacagctac acccacgcac tgtgcctatg acaggatcgt ggttgcaggg      720

atgctgctcc gaggcgccgt tgttcccgac tcggctcttc cctttaactt ccaggctgcc      780

tatggcctga gtgaccaact ggcccaagcc atcagtgacc actatccagt ggaggtgatg      840

ctgaag                                                                 846


<210>  16
<211>  282
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(22)
<223>  human DNase 1 signal peptide

<220>
<221>  SIGNAL
<222>  (1)..(22)

<400>  16

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  17
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F] DNA

<400>  17
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840


<210>  18
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 leader peptide

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  N74K substitution

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  G105R substitution

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  A114F substitution

<400>  18

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210>  19
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 G105R-A114F] DNA

<400>  19
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga acagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840


<210>  20
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 G105R-A114F]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 leader peptide

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  G105R substitution

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  A114F substitution

<400>  20

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210>  21
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  21
atggctctgg agaagtctct tgtccggctc cttctgcttg tcctgatact gctggtgctg       60

ggctgggtcc agccttccct gggcaaggaa tcccgggcca agaaattcca gcggcagcat      120

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc      180

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta      240

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc      300

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac      360

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg      420

agcccatatg tgccagtcca ctttgatgct tctgtggagg actctacc                   468


<210>  22
<211>  156
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(28)
<223>  human RNase signal peptide

<400>  22

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     


<210>  23
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-RNase1 DNA

<400>  23
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacgactcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc taca                                             444


<210>  24
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-RNase1


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 leader peptide

<400>  24

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr 
145             


<210>  25
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SCC hinge, wild-type CH2 and CH3)

<400>  25
gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctgtctccg ggtaaa                                696


<210>  26
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc (SCC hinge, wild-type CH2 and CH3)

<400>  26

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  27
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SSS hinge, P238S, P331S)

<400>  27
gagcccaaat cttctgacaa aactcacaca tctccaccgt ccccagcacc tgaactcctg       60

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctctctccg ggtaaa                                696


<210>  28
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc (SSS hinge, P238S, P331S)


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  IgG1 hinge C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  IgG1 hinge C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  IgG1 hinge C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  IgG1 lower hinge-CH2 P238S substitution

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  IgG1 Fc P331S substitution

<400>  28

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  29
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (g4s)4-[SSShinge-P238S-P331S Fc] DNA

<400>  29
gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga       60

ggtggttcta ccggtctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      120

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac      180

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      240

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      300

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      360

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      420

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      480

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      540

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      600

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag      660

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat      720

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaa            774


<210>  30
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (g4s)4-[SSShinge-P238S-P331S Fc]


<220>
<221>  MISC_FEATURE
<222>  (1)..(26)
<223>  (Gly4Ser)4 linker (including additional restriction site amino 
       acids)

<220>
<221>  MISC_FEATURE
<222>  (27)..(258)
<223>  human IgG1 hinge-CH2-CH3 with substituted amino acids

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  human IgG1 hinge C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  human IgG1 hinge C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  human IgG1 hinge C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  human IgG1 lower hinge-CH2 P238S substitution

<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  human IgG1 P331S substitution

<400>  30

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp 
            20                  25                  30          


Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly 
        35                  40                  45              


Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    50                  55                  60                  


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
65                  70                  75                  80  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                85                  90                  95      


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            100                 105                 110         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        115                 120                 125             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
145                 150                 155                 160 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                165                 170                 175     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            180                 185                 190         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
225                 230                 235                 240 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                245                 250                 255     


Gly Lys 
        


<210>  31
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  31
atggcgacga aggccgtgtg cgtgctgaag ggcgacggcc cagtgcaggg catcatcaat       60

ttcgagcaga aggaaagtaa tggaccagtg aaggtgtggg gaagcattaa aggactgact      120

gaaggcctgc atggattcca tgttcatgag tttggagata atacagcagg ctgtaccagt      180

gcaggtcctc actttaatcc tctatccaga aaacacggtg ggccaaagga tgaagagagg      240

catgttggag acttgggcaa tgtgactgct gacaaagatg gtgtggccga tgtgtctatt      300

gaagattctg tgatctcact ctcaggagac cattgcatca ttggccgcac actggtggtc      360

catgaaaaag cagatgactt gggcaaaggt ggaaatgaag aaagtacaaa gacaggaaac      420

gctggaagtc gtttggcttg tggtgtaatt gggatcgccc aa                         462


<210>  32
<211>  154
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (1)..(154)
<223>  human SOD1 wild type sequence

<300>
<308>  NM_000454.5
<309>  2020-06-07
<313>  (1)..(154)

<300>
<308>  CR450355.1
<309>  2016-07-26
<313>  (1)..(154)

<300>
<308>  CR541742.1
<309>  2008-10-16
<313>  (1)..(154)

<400>  32

Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210>  33
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRNase1-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  33
atggctctgg agaagtctct tgtccggctc cttctgcttg tcctgatact gctggtgctg       60

ggctgggtcc agccttccct gggcaaggaa tcccgggcca agaaattcca gcggcagcat      120

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc      180

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta      240

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc      300

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac      360

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg      420

agcccatatg tgccagtcca ctttgatgct tctgtggagg actctacaga tctctccgga      480

ggaggtggct caggtggtgg aggatctgga ggaggtggga gtggtggagg tggttctacc      540

ggtctcgagc ccaaatcttc tgacaaaact cacacatctc caccgtcccc agcacctgaa      600

ctcctggggg gatcgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      660

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      720

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      780

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      840

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      900

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      960

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1020

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1080

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1140

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1200

aaccactaca cgcagaagag cctctctctg tctccgggta aa                        1242


<210>  34
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRNase1-(g4s)4-[SSShinge-P238S Fc]


<220>
<221>  SIGNAL
<222>  (1)..(28)
<223>  human RNase signal sequence

<220>
<221>  MISC_FEATURE
<222>  (29)..(166)
<223>  human RNase1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (167)..(182)
<223>  human (gly4ser)4 linker peptide with additional restriction site 
       amino acids

<220>
<221>  MISC_FEATURE
<222>  (183)..(414)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (187)..(187)
<223>  human IgG1 hinge C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  human IgG1 hinge C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  human IgG1 hinge C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  human IgG1lower hinge-CH2 P238S substitution

<400>  34

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr Asp Leu Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            180                 185                 190         


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
        195                 200                 205             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    210                 215                 220                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
225                 230                 235                 240 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                245                 250                 255     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            260                 265                 270         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        275                 280                 285             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    290                 295                 300                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
305                 310                 315                 320 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                325                 330                 335     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            340                 345                 350         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        355                 360                 365             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    370                 375                 380                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
385                 390                 395                 400 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410                 


<210>  35
<211>  1218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  35
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacgactcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc tccggaggag gtggctcagg tggtggagga      480

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      540

aaaactcaca catctccacc gtccccagca cctgaactcc tggggggatc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      960

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tctctgtctc cgggtaaa                                                   1218


<210>  36
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-(g4s)4-[SSShinge-P238S Fc]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 signal peptide

<220>
<221>  MISC_FEATURE
<222>  (21)..(158)
<223>  human RNase 1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (159)..(174)
<223>  (gly4ser)4 linker peptide with additional restriction site amino 
       acids

<220>
<221>  MISC_FEATURE
<222>  (175)..(406)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  human IgG1 hinge C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  human IgG1 hinge C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (188)..(188)
<223>  human IgG1 hinge C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  human IgG1 lower hinge-CH2 P238S substitution

<400>  36

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Asp Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
                165                 170                 175     


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys 
                405     


<210>  37
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRNase1-(g4s)4-[SSSH-P238S Fc]-NGS-[PON1 Q192K) DNA

<400>  37
atggctctgg agaagtctct tgtccggctc cttctgcttg tcctgatact gctggtgctg       60

ggctgggtcc agccttccct gggcaaggaa tcccgggcca agaaattcca gcggcagcat      120

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc      180

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta      240

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc      300

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac      360

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg      420

agcccatatg tgccagtcca ctttgatgct tctgtggagg actctacaga tctctccgga      480

ggaggtggct caggtggtgg aggatctgga ggaggtggga gtggtggagg tggttctacc      540

ggtctcgagc ccaaatcttc tgacaaaact cacacatctc caccgtcccc agcacctgaa      600

ctcctgggag gatcgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      660

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      720

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      780

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      840

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      900

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      960

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1020

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1080

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1140

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1200

aaccactaca cgcagaagag cctctctctc tctccgggta aagtcgacgg agctagcagc     1260

cccgtgaacg tgagcagccc cagcgtgcag gatatcctct tcaggaacca ccagtcttct     1320

taccaaacac gacttaatgc tctccgagag gtacaacccg tagaacttcc taactgtaat     1380

ttagttaaag gaatcgaaac tggctctgaa gacttggaga tactgcctaa tggactggct     1440

ttcattagct ctggattaaa gtatcctgga ataaagagct tcaaccccaa cagtcctgga     1500

aaaatacttc tgatggacct gaatgaagaa gatccaacag tgttggaatt ggggatcact     1560

ggaagtaaat ttgatgtatc ttcatttaac cctcatggga ttagcacatt cacagatgaa     1620

gataatgcca tgtacctcct ggtggtgaac catccagatg ccaagtccac agtggagttg     1680

tttaaatttc aagaagaaga aaaatcgctt ttgcatctaa aaaccatcag acataaactt     1740

ctgcctaatt tgaatgatat tgttgctgtg ggacctgagc acttttatgg cacaaatgat     1800

cactattttc ttgaccccta cttaaaatcc tgggagatgt atttgggttt agcgtggtcg     1860

tatgttgtct actatagtcc aagtgaagtt cgagtggtgg cagaaggatt tgattttgct     1920

aatggaatca acatttcacc cgatggcaag tatgtctata tagctgagtt gctggctcat     1980

aagattcatg tgtatgaaaa gcatgctaat tggactttaa ctccattgaa gtcccttgac     2040

tttaataccc tcgtggataa catatctgtg gatcctgaga caggagacct ttgggttgga     2100

tgccatccca atggcatgaa aatcttcttc tatgactcag agaatcctcc tgcatcagag     2160

gtgcttcgaa tccagaacat tctaacagaa gaacctaaag tgacacaggt ttatgcagaa     2220

aatggcacag tgttgcaagg cagtacagtt gcctctgtgt acaaagggaa actgctgatt     2280

ggcacagtgt ttcacaaagc tctttactgt gagctc                               2316


<210>  38
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRNase1-(g4s)4-[SSSH-P238S Fc]-NGS-[PON1 Q192K)


<220>
<221>  SIGNAL
<222>  (1)..(28)
<223>  human RNase 1 signal peptide

<220>
<221>  MISC_FEATURE
<222>  (29)..(156)
<223>  human RNase 1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (157)..(182)
<223>  (gly4ser)4 linker peptide with additional restriction site amino 
       acids

<220>
<221>  MISC_FEATURE
<222>  (183)..(414)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (187)..(187)
<223>  Human IgG1 hinge C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  Human IgG1 hinge C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  Human IgG1 hinge C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  Human IgG1 lower hinge-CH2 P238S substitution

<220>
<221>  MISC_FEATURE
<222>  (415)..(433)
<223>  peptide linker containing N-linked glyscosylation site

<220>
<221>  MISC_FEATURE
<222>  (434)..(772)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (609)..(609)
<223>  PON1 Q192K amino acid substitution

<400>  38

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr Asp Leu Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            180                 185                 190         


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
        195                 200                 205             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    210                 215                 220                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
225                 230                 235                 240 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                245                 250                 255     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            260                 265                 270         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        275                 280                 285             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    290                 295                 300                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
305                 310                 315                 320 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                325                 330                 335     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            340                 345                 350         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        355                 360                 365             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    370                 375                 380                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
385                 390                 395                 400 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
                405                 410                 415     


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
            420                 425                 430         


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
        435                 440                 445             


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
    450                 455                 460                 


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
465                 470                 475                 480 


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
                485                 490                 495     


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
            500                 505                 510         


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
        515                 520                 525             


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
    530                 535                 540                 


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
545                 550                 555                 560 


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
                565                 570                 575     


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
            580                 585                 590         


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
        595                 600                 605             


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
    610                 615                 620                 


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
625                 630                 635                 640 


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
                645                 650                 655     


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
            660                 665                 670         


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
        675                 680                 685             


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
    690                 695                 700                 


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
705                 710                 715                 720 


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
                725                 730                 735     


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
            740                 745                 750         


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
        755                 760                 765             


Tyr Cys Glu Leu 
    770         


<210>  39
<211>  2292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 Q192K] DNA

<400>  39
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc tccggaggag gtggctcagg tggtggagga      480

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      540

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      960

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1260

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1320

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1380

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1440

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1500

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1560

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1620

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1680

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     1740

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     1800

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     1860

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     1920

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     1980

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2040

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2100

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2160

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2220

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2280

tactgtgagc tc                                                         2292


<210>  40
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 signal peptide

<220>
<221>  MISC_FEATURE
<222>  (21)..(148)
<223>  human RNase1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (149)..(174)
<223>  (gly4ser)4 linker peptide with addtional restriction site amino 
       acids

<220>
<221>  MISC_FEATURE
<222>  (175)..(406)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (188)..(188)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  human IgG1 lower hinge-CH2 P238S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (407)..(425)
<223>  peptide linker containing N linked glyscosylation site

<220>
<221>  MISC_FEATURE
<222>  (426)..(764)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (601)..(601)
<223>  PON1 Q192K amino acid substitution

<400>  40

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
                165                 170                 175     


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val 
                405                 410                 415     


Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser 
            420                 425                 430         


Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu 
        435                 440                 445             


Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu 
    450                 455                 460                 


Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr 
465                 470                 475                 480 


Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu 
                485                 490                 495     


Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr 
            500                 505                 510         


Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr 
        515                 520                 525             


Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro 
    530                 535                 540                 


Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys 
545                 550                 555                 560 


Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu 
                565                 570                 575     


Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp 
            580                 585                 590         


His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly 
        595                 600                 605             


Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val 
    610                 615                 620                 


Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp 
625                 630                 635                 640 


Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val 
                645                 650                 655     


Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp 
            660                 665                 670         


Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp 
        675                 680                 685             


Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp 
    690                 695                 700                 


Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu 
705                 710                 715                 720 


Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val 
                725                 730                 735     


Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile 
            740                 745                 750         


Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
        755                 760                 


<210>  41
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRNase1-[SSShinge-P238S Fc] DNA

<400>  41
atggctctgg agaagtctct tgtccggctc cttctgcttg tcctgatact gctggtgctg       60

ggctgggtcc agccttccct gggcaaggaa tcccgggcca agaaattcca gcggcagcat      120

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc      180

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta      240

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc      300

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac      360

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg      420

agcccatatg tgccagtcca ctttgatgct tctgtggagg actctacaga tctcgagccc      480

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggggga      540

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      600

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      660

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      720

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      780

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      840

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      900

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      960

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1020

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1080

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1140

cagaagagcc tctctctgtc tccgggtaaa                                      1170


<210>  42
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRNase1-[SSShinge-P238S Fc]


<220>
<221>  SIGNAL
<222>  (1)..(28)
<223>  human RNase1 signal peptide

<220>
<221>  MISC_FEATURE
<222>  (29)..(156)
<223>  human RNase1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (157)..(158)
<223>  restriction site amino acids

<220>
<221>  MISC_FEATURE
<222>  (159)..(390)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  human IgG1 hinge domain C220S substitution

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  human IgG1 hinge domain C226S substitution

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  human IgG1 hinge domain C229S substitution

<220>
<221>  MISC_FEATURE
<222>  (181)..(181)
<223>  human IgG1 lower hinge-CH2 domain P238S substitution

<400>  42

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr Asp Leu Glu Pro 
145                 150                 155                 160 


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
                165                 170                 175     


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            180                 185                 190         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        195                 200                 205             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    210                 215                 220                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
225                 230                 235                 240 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                245                 250                 255     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            260                 265                 270         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        275                 280                 285             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    290                 295                 300                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
305                 310                 315                 320 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                325                 330                 335     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            340                 345                 350         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        355                 360                 365             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    370                 375                 380                 


Ser Leu Ser Pro Gly Lys 
385                 390 


<210>  43
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-[SSShinge-P238S Fc] DNA

<400>  43
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacgactcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc gagcccaaat cttctgacaa aactcacaca      480

tctccaccgt ccccagcacc tgaactcctg gggggatcgt cagtcttcct cttcccccca      540

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      600

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      660

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      720

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      780

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      840

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      900

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      960

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1020

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1080

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctgtctccg     1140

ggtaaa                                                                1146


<210>  44
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-[SSShinge-P238S Fc]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  Human VK3 leader peptide

<220>
<221>  MISC_FEATURE
<222>  (21)..(148)
<223>  human RNase 1 mature polytpeptide

<220>
<221>  MISC_FEATURE
<222>  (149)..(150)
<223>  restriction site amino acids

<220>
<221>  MISC_FEATURE
<222>  (151)..(382)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (173)..(173)
<223>  human IgG1 lower hinge-CH2 P238S amino acid substitution

<400>  44

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Asp Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
145                 150                 155                 160 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
                165                 170                 175     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        195                 200                 205             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    210                 215                 220                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                245                 250                 255     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            260                 265                 270         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        275                 280                 285             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    290                 295                 300                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
305                 310                 315                 320 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                325                 330                 335     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            340                 345                 350         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        355                 360                 365             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380         


<210>  45
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRNase1-[SSShinge-P238S Fc]-NGS-[PON1 Q192K] DNA

<400>  45
atggctctgg agaagtctct tgtccggctc cttctgcttg tcctgatact gctggtgctg       60

ggctgggtcc agccttccct gggcaaggaa tcccgggcca agaaattcca gcggcagcat      120

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc      180

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta      240

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc      300

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac      360

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg      420

agcccatatg tgccagtcca ctttgatgct tctgtggagg actctacaga tctcgagccc      480

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      540

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      600

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      660

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      720

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      780

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      840

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      900

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      960

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1020

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1080

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1140

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1200

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1260

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1320

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1380

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1440

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1500

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1560

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     1620

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     1680

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     1740

gacccctact taaaatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     1800

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     1860

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     1920

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     1980

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2040

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2100

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2160

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2220

cacaaagctc tttactgtga gctc                                            2244


<210>  46
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRNase1-[SSShinge-P238S Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(28)
<223>  human RNase 1 signal peptide

<220>
<221>  MISC_FEATURE
<222>  (29)..(156)
<223>  human RNase 1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (157)..(158)
<223>  restriction site amino acids

<220>
<221>  MISC_FEATURE
<222>  (159)..(390)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  human IgG1lower hinge-CH2 P238S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (391)..(409)
<223>  peptide linker containing N-linked glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (410)..(748)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (585)..(585)
<223>  human PON1 Q192K amino acid substitution

<400>  46

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr Asp Leu Glu Pro 
145                 150                 155                 160 


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
                165                 170                 175     


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            180                 185                 190         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        195                 200                 205             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    210                 215                 220                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
225                 230                 235                 240 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                245                 250                 255     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            260                 265                 270         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        275                 280                 285             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    290                 295                 300                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
305                 310                 315                 320 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                325                 330                 335     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            340                 345                 350         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        355                 360                 365             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    370                 375                 380                 


Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val 
385                 390                 395                 400 


Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser 
                405                 410                 415     


Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu 
            420                 425                 430         


Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu 
        435                 440                 445             


Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr 
    450                 455                 460                 


Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu 
465                 470                 475                 480 


Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr 
                485                 490                 495     


Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr 
            500                 505                 510         


Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro 
        515                 520                 525             


Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys 
    530                 535                 540                 


Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu 
545                 550                 555                 560 


Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp 
                565                 570                 575     


His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly 
            580                 585                 590         


Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val 
        595                 600                 605             


Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp 
    610                 615                 620                 


Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val 
625                 630                 635                 640 


Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp 
                645                 650                 655     


Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp 
            660                 665                 670         


Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp 
        675                 680                 685             


Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu 
    690                 695                 700                 


Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val 
705                 710                 715                 720 


Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile 
                725                 730                 735     


Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            740                 745             


<210>  47
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-[SSShinge-P238S Fc]-NGS-[PON1 Q192K] DNA

<400>  47
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc      120

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      180

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      240

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      300

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      360

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      420

gatgcttctg tggaggactc tacagatctc gagcccaaat cttctgacaa aactcacaca      480

tctccaccgt ccccagcacc tgaactcctg ggaggatcgt cagtcttcct cttcccccca      540

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      600

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      660

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      720

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      780

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      840

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      900

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      960

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1020

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1080

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctctctccg     1140

ggtaaagtcg acggagctag cagccccgtg aacgtgagca gccccagcgt gcaggatatc     1200

ctcttcagga accaccagtc ttcttaccaa acacgactta atgctctccg agaggtacaa     1260

cccgtagaac ttcctaactg taatttagtt aaaggaatcg aaactggctc tgaagacttg     1320

gagatactgc ctaatggact ggctttcatt agctctggat taaagtatcc tggaataaag     1380

agcttcaacc ccaacagtcc tggaaaaata cttctgatgg acctgaatga agaagatcca     1440

acagtgttgg aattggggat cactggaagt aaatttgatg tatcttcatt taaccctcat     1500

gggattagca cattcacaga tgaagataat gccatgtacc tcctggtggt gaaccatcca     1560

gatgccaagt ccacagtgga gttgtttaaa tttcaagaag aagaaaaatc gcttttgcat     1620

ctaaaaacca tcagacataa acttctgcct aatttgaatg atattgttgc tgtgggacct     1680

gagcactttt atggcacaaa tgatcactat tttcttgacc cctacttaaa atcctgggag     1740

atgtatttgg gtttagcgtg gtcgtatgtt gtctactata gtccaagtga agttcgagtg     1800

gtggcagaag gatttgattt tgctaatgga atcaacattt cacccgatgg caagtatgtc     1860

tatatagctg agttgctggc tcataagatt catgtgtatg aaaagcatgc taattggact     1920

ttaactccat tgaagtccct tgactttaat accctcgtgg ataacatatc tgtggatcct     1980

gagacaggag acctttgggt tggatgccat cccaatggca tgaaaatctt cttctatgac     2040

tcagagaatc ctcctgcatc agaggtgctt cgaatccaga acattctaac agaagaacct     2100

aaagtgacac aggtttatgc agaaaatggc acagtgttgc aaggcagtac agttgcctct     2160

gtgtacaaag ggaaactgct gattggcaca gtgtttcaca aagctcttta ctgtgagctc     2220


<210>  48
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hRNase1-[SSShinge-P238S Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(20)
<223>  human VK3 leader peptide

<220>
<221>  MISC_FEATURE
<222>  (21)..(148)
<223>  human RNase 1 mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (149)..(150)
<223>  restriction site amino acids

<220>
<221>  MISC_FEATURE
<222>  (151)..(382)
<223>  human IgG1 variant Fc (SSS hinge, P238S)

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (173)..(173)
<223>  human IgG1 lower hinge-CH2 P238S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (383)..(401)
<223>  peptide linker containing N-linked glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (402)..(740)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (577)..(577)
<223>  human PON1 Q192K amino acid substitution

<400>  48

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His 
            20                  25                  30          


Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln 
        35                  40                  45              


Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn 
    50                  55                  60                  


Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln 
65                  70                  75                  80  


Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn 
                85                  90                  95      


Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr 
            100                 105                 110         


Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val 
        115                 120                 125             


Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val 
    130                 135                 140                 


Glu Asp Ser Thr Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
145                 150                 155                 160 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
                165                 170                 175     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            180                 185                 190         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        195                 200                 205             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    210                 215                 220                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
225                 230                 235                 240 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                245                 250                 255     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            260                 265                 270         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        275                 280                 285             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    290                 295                 300                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
305                 310                 315                 320 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                325                 330                 335     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            340                 345                 350         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        355                 360                 365             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
    370                 375                 380                 


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
385                 390                 395                 400 


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
                405                 410                 415     


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
            420                 425                 430         


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
        435                 440                 445             


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
    450                 455                 460                 


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
465                 470                 475                 480 


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
                485                 490                 495     


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
            500                 505                 510         


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
        515                 520                 525             


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
    530                 535                 540                 


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
545                 550                 555                 560 


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
                565                 570                 575     


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
            580                 585                 590         


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
        595                 600                 605             


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
    610                 615                 620                 


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
625                 630                 635                 640 


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
                645                 650                 655     


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
            660                 665                 670         


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
        675                 680                 685             


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
    690                 695                 700                 


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
705                 710                 715                 720 


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
                725                 730                 735     


Tyr Cys Glu Leu 
            740 


<210>  49
<211>  2343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hSOD1-(g4s)2-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K] 
       DNA

<400>  49
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atggcggcaa cgaaggccgt gtgcgtgctg aagggcgacg gcccagtgca gggcatcatc      120

aatttcgagc agaaggaaag taatggacca gtgaaggtgt ggggaagcat taaaggactg      180

actgaaggcc tgcatggatt ccatgttcat gagtttggag ataatacagc aggctgtacc      240

agtgcaggtc ctcactttaa tcctctatcc agaaaacacg gtgggccaaa ggatgaagag      300

aggcatgttg gagacttggg caatgtgact gctgacaaag atggtgtggc cgatgtgtct      360

attgaagatt ctgtgatctc actctcagga gaccattgca tcattggccg cacactggtg      420

gtccatgaaa aagcagatga cttgggcaaa ggtggaaatg aagaaagtac aaagacagga      480

aacgctggaa gtcgtttggc ttgtggtgta attgggatcg cccaagatct ctccggagga      540

ggtggctcag gtggtggagg atctaccggt ctcgagccca aatcttctga caaaactcac      600

acatctccac cgtccccagc acctgaactc ctgggaggat cgtcagtctt cctcttcccc      660

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      720

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      780

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      840

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      900

aacaaagccc tcccagcctc catcgagaaa accatctcca aagccaaagg gcagccccga      960

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1020

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1080

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1140

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1200

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctctctctct     1260

ccgggtaaag tcgacggagc tagcagcccc gtgaacgtga gcagccccag cgtgcaggat     1320

atcctcttca ggaaccacca gtcttcttac caaacacgac ttaatgctct ccgagaggta     1380

caacccgtag aacttcctaa ctgtaattta gttaaaggaa tcgaaactgg ctctgaagac     1440

ttggagatac tgcctaatgg actggctttc attagctctg gattaaagta tcctggaata     1500

aagagcttca accccaacag tcctggaaaa atacttctga tggacctgaa tgaagaagat     1560

ccaacagtgt tggaattggg gatcactgga agtaaatttg atgtatcttc atttaaccct     1620

catgggatta gcacattcac agatgaagat aatgccatgt acctcctggt ggtgaaccat     1680

ccagatgcca agtccacagt ggagttgttt aaatttcaag aagaagaaaa atcgcttttg     1740

catctaaaaa ccatcagaca taaacttctg cctaatttga atgatattgt tgctgtggga     1800

cctgagcact tttatggcac aaatgatcac tattttcttg acccctactt aaaatcctgg     1860

gagatgtatt tgggtttagc gtggtcgtat gttgtctact atagtccaag tgaagttcga     1920

gtggtggcag aaggatttga ttttgctaat ggaatcaaca tttcacccga tggcaagtat     1980

gtctatatag ctgagttgct ggctcataag attcatgtgt atgaaaagca tgctaattgg     2040

actttaactc cattgaagtc ccttgacttt aataccctcg tggataacat atctgtggat     2100

cctgagacag gagacctttg ggttggatgc catcccaatg gcatgaaaat cttcttctat     2160

gactcagaga atcctcctgc atcagaggtg cttcgaatcc agaacattct aacagaagaa     2220

cctaaagtga cacaggttta tgcagaaaat ggcacagtgt tgcaaggcag tacagttgcc     2280

tctgtgtaca aagggaaact gctgattggc acagtgtttc acaaagctct ttactgtgag     2340

ctc                                                                   2343


<210>  50
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-hSOD1-(g4s)2-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(22)
<223>  human VK3 leader peptide with 2 additional amino acids to drive 
       correct cleavage

<220>
<221>  MISC_FEATURE
<222>  (23)..(175)
<223>  human SOD 1 without N-terminal methionine

<220>
<221>  MISC_FEATURE
<222>  (176)..(191)
<223>  (gly4ser)2 linker peptide with additional restriction site amino 
       acids

<220>
<221>  MISC_FEATURE
<222>  (192)..(483)
<223>  human IgG1 variant Fc (SSS hinge, P238S, P331S)

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  human IgG1 lower hinge-CH2 P238S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (307)..(307)
<223>  human IgG1 Fc P331S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (424)..(442)
<223>  peptide linker containing N-linked glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (443)..(781)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (618)..(618)
<223>  human PON1 Q192K amino acid substitution

<400>  50

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Ala Ala Thr Lys Ala Val Cys Val Leu Lys Gly 
            20                  25                  30          


Asp Gly Pro Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn 
        35                  40                  45              


Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu 
    50                  55                  60                  


His Gly Phe His Val His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr 
65                  70                  75                  80  


Ser Ala Gly Pro His Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro 
                85                  90                  95      


Lys Asp Glu Glu Arg His Val Gly Asp Leu Gly Asn Val Thr Ala Asp 
            100                 105                 110         


Lys Asp Gly Val Ala Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu 
        115                 120                 125             


Ser Gly Asp His Cys Ile Ile Gly Arg Thr Leu Val Val His Glu Lys 
    130                 135                 140                 


Ala Asp Asp Leu Gly Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly 
145                 150                 155                 160 


Asn Ala Gly Ser Arg Leu Ala Cys Gly Val Ile Gly Ile Ala Gln Asp 
                165                 170                 175     


Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
            180                 185                 190         


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
        195                 200                 205             


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    210                 215                 220                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
225                 230                 235                 240 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                245                 250                 255     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            260                 265                 270         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        275                 280                 285             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    290                 295                 300                 


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
305                 310                 315                 320 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                325                 330                 335     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            340                 345                 350         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        355                 360                 365             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    370                 375                 380                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
385                 390                 395                 400 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                405                 410                 415     


Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn 
            420                 425                 430         


Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser 
        435                 440                 445             


Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu 
    450                 455                 460                 


Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp 
465                 470                 475                 480 


Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys 
                485                 490                 495     


Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu 
            500                 505                 510         


Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile 
        515                 520                 525             


Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser 
    530                 535                 540                 


Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His 
545                 550                 555                 560 


Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu 
                565                 570                 575     


Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn 
            580                 585                 590         


Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn 
        595                 600                 605             


Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu 
    610                 615                 620                 


Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg 
625                 630                 635                 640 


Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro 
                645                 650                 655     


Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His 
            660                 665                 670         


Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu 
        675                 680                 685             


Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly 
    690                 695                 700                 


Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr 
705                 710                 715                 720 


Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile 
                725                 730                 735     


Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr 
            740                 745                 750         


Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu 
        755                 760                 765             


Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
    770                 775                 780     


<210>  51
<211>  2343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hSOD1 C6A C111S]-(g4s)2-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  51
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atggcggcaa cgaaggccgt ggctgtgctg aagggcgacg gcccagtgca gggcatcatc      120

aatttcgagc agaaggaaag taatggacca gtgaaggtgt ggggaagcat taaaggactg      180

actgaaggcc tgcatggatt ccatgttcat gagtttggag ataatacagc aggctgtacc      240

agtgcaggtc ctcactttaa tcctctatcc agaaaacacg gtgggccaaa ggatgaagag      300

aggcatgttg gagacttggg caatgtgact gctgacaaag atggtgtggc cgatgtgtct      360

attgaagatt ctgtgatctc actctcagga gaccattcaa tcattggccg cacactggtg      420

gtccatgaaa aagcagatga cttgggcaaa ggtggaaatg aagaaagtac aaagacagga      480

aacgctggaa gtcgtttggc ttgtggtgta attgggatcg cccaagatct ctccggagga      540

ggtggctcag gtggtggagg atctaccggt ctcgagccca aatcttctga caaaactcac      600

acatctccac cgtccccagc acctgaactc ctgggaggat cgtcagtctt cctcttcccc      660

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      720

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      780

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      840

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      900

aacaaagccc tcccagcctc catcgagaaa accatctcca aagccaaagg gcagccccga      960

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1020

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1080

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1140

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1200

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctctctctct     1260

ccgggtaaag tcgacggagc tagcagcccc gtgaacgtga gcagccccag cgtgcaggat     1320

atcctcttca ggaaccacca gtcttcttac caaacacgac ttaatgctct ccgagaggta     1380

caacccgtag aacttcctaa ctgtaattta gttaaaggaa tcgaaactgg ctctgaagac     1440

ttggagatac tgcctaatgg actggctttc attagctctg gattaaagta tcctggaata     1500

aagagcttca accccaacag tcctggaaaa atacttctga tggacctgaa tgaagaagat     1560

ccaacagtgt tggaattggg gatcactgga agtaaatttg atgtatcttc atttaaccct     1620

catgggatta gcacattcac agatgaagat aatgccatgt acctcctggt ggtgaaccat     1680

ccagatgcca agtccacagt ggagttgttt aaatttcaag aagaagaaaa atcgcttttg     1740

catctaaaaa ccatcagaca taaacttctg cctaatttga atgatattgt tgctgtggga     1800

cctgagcact tttatggcac aaatgatcac tattttcttg acccctactt aaaatcctgg     1860

gagatgtatt tgggtttagc gtggtcgtat gttgtctact atagtccaag tgaagttcga     1920

gtggtggcag aaggatttga ttttgctaat ggaatcaaca tttcacccga tggcaagtat     1980

gtctatatag ctgagttgct ggctcataag attcatgtgt atgaaaagca tgctaattgg     2040

actttaactc cattgaagtc ccttgacttt aataccctcg tggataacat atctgtggat     2100

cctgagacag gagacctttg ggttggatgc catcccaatg gcatgaaaat cttcttctat     2160

gactcagaga atcctcctgc atcagaggtg cttcgaatcc agaacattct aacagaagaa     2220

cctaaagtga cacaggttta tgcagaaaat ggcacagtgt tgcaaggcag tacagttgcc     2280

tctgtgtaca aagggaaact gctgattggc acagtgtttc acaaagctct ttactgtgag     2340

ctc                                                                   2343


<210>  52
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hSOD1 C6A C111S]-(g4s)2-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(22)
<223>  human VK3 leader peptide with 2 additional amino acids to drive 
       correct cleavage

<220>
<221>  MISC_FEATURE
<222>  (23)..(175)
<223>  human SOD1 C6A-C111S without N-terminal methionine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  human SOD 1 C6A amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  human SOD 1 C111S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (176)..(191)
<223>  (gly4ser)2 linker peptide with additional restriction site amino 
       acids

<220>
<221>  MISC_FEATURE
<222>  (192)..(423)
<223>  human IgG1 variant Fc (SSS hinge, P238S, P331S)

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (202)..(202)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (215)..(215)
<223>  human IgG1 lower hinge-CH2 P238S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (307)..(307)
<223>  human IgG1 Fc P331S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (424)..(442)
<223>  linker peptide containing N-linked glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (443)..(781)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (618)..(618)
<223>  human PON1 Q192K amino acid substitution

<400>  52

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Ala Ala Thr Lys Ala Val Ala Val Leu Lys Gly 
            20                  25                  30          


Asp Gly Pro Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn 
        35                  40                  45              


Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu 
    50                  55                  60                  


His Gly Phe His Val His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr 
65                  70                  75                  80  


Ser Ala Gly Pro His Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro 
                85                  90                  95      


Lys Asp Glu Glu Arg His Val Gly Asp Leu Gly Asn Val Thr Ala Asp 
            100                 105                 110         


Lys Asp Gly Val Ala Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu 
        115                 120                 125             


Ser Gly Asp His Ser Ile Ile Gly Arg Thr Leu Val Val His Glu Lys 
    130                 135                 140                 


Ala Asp Asp Leu Gly Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly 
145                 150                 155                 160 


Asn Ala Gly Ser Arg Leu Ala Cys Gly Val Ile Gly Ile Ala Gln Asp 
                165                 170                 175     


Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
            180                 185                 190         


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
        195                 200                 205             


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    210                 215                 220                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
225                 230                 235                 240 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                245                 250                 255     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            260                 265                 270         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        275                 280                 285             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    290                 295                 300                 


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
305                 310                 315                 320 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                325                 330                 335     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            340                 345                 350         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        355                 360                 365             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    370                 375                 380                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
385                 390                 395                 400 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                405                 410                 415     


Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn 
            420                 425                 430         


Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser 
        435                 440                 445             


Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu 
    450                 455                 460                 


Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp 
465                 470                 475                 480 


Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys 
                485                 490                 495     


Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu 
            500                 505                 510         


Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile 
        515                 520                 525             


Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser 
    530                 535                 540                 


Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His 
545                 550                 555                 560 


Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu 
                565                 570                 575     


Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn 
            580                 585                 590         


Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn 
        595                 600                 605             


Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu 
    610                 615                 620                 


Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg 
625                 630                 635                 640 


Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro 
                645                 650                 655     


Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His 
            660                 665                 670         


Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu 
        675                 680                 685             


Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly 
    690                 695                 700                 


Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr 
705                 710                 715                 720 


Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile 
                725                 730                 735     


Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr 
            740                 745                 750         


Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu 
        755                 760                 765             


Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
    770                 775                 780     


<210>  53
<211>  2373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hSOD1 C6A C111S]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  53
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atggcggcaa cgaaggccgt ggctgtgctg aagggcgacg gcccagtgca gggcatcatc      120

aatttcgagc agaaggaaag taatggacca gtgaaggtgt ggggaagcat taaaggactg      180

actgaaggcc tgcatggatt ccatgttcat gagtttggag ataatacagc aggctgtacc      240

agtgcaggtc ctcactttaa tcctctatcc agaaaacacg gtgggccaaa ggatgaagag      300

aggcatgttg gagacttggg caatgtgact gctgacaaag atggtgtggc cgatgtgtct      360

attgaagatt ctgtgatctc actctcagga gaccattcaa tcattggccg cacactggtg      420

gtccatgaaa aagcagatga cttgggcaaa ggtggaaatg aagaaagtac aaagacagga      480

aacgctggaa gtcgtttggc ttctggtgta attgggatcg cccaagatct ctccggagga      540

ggtggctcag gtggtggagg atctggagga ggtgggagtg gtggaggtgg ttctaccggt      600

ctcgagccca aatcttctga caaaactcac acatctccac cgtccccagc acctgaactc      660

ctgggaggat cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      720

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      780

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      840

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      900

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcctc catcgagaaa      960

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1020

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1080

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1140

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1200

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1260

cactacacgc agaagagcct ctctctctct ccgggtaaag tcgacggagc tagcagcccc     1320

gtgaacgtga gcagccccag cgtgcaggat atcctcttca ggaaccacca gtcttcttac     1380

caaacacgac ttaatgctct ccgagaggta caacccgtag aacttcctaa ctgtaattta     1440

gttaaaggaa tcgaaactgg ctctgaagac ttggagatac tgcctaatgg actggctttc     1500

attagctctg gattaaagta tcctggaata aagagcttca accccaacag tcctggaaaa     1560

atacttctga tggacctgaa tgaagaagat ccaacagtgt tggaattggg gatcactgga     1620

agtaaatttg atgtatcttc atttaaccct catgggatta gcacattcac agatgaagat     1680

aatgccatgt acctcctggt ggtgaaccat ccagatgcca agtccacagt ggagttgttt     1740

aaatttcaag aagaagaaaa atcgcttttg catctaaaaa ccatcagaca taaacttctg     1800

cctaatttga atgatattgt tgctgtggga cctgagcact tttatggcac aaatgatcac     1860

tattttcttg acccctactt aaaatcctgg gagatgtatt tgggtttagc gtggtcgtat     1920

gttgtctact atagtccaag tgaagttcga gtggtggcag aaggatttga ttttgctaat     1980

ggaatcaaca tttcacccga tggcaagtat gtctatatag ctgagttgct ggctcataag     2040

attcatgtgt atgaaaagca tgctaattgg actttaactc cattgaagtc ccttgacttt     2100

aataccctcg tggataacat atctgtggat cctgagacag gagacctttg ggttggatgc     2160

catcccaatg gcatgaaaat cttcttctat gactcagaga atcctcctgc atcagaggtg     2220

cttcgaatcc agaacattct aacagaagaa cctaaagtga cacaggttta tgcagaaaat     2280

ggcacagtgt tgcaaggcag tacagttgcc tctgtgtaca aagggaaact gctgattggc     2340

acagtgtttc acaaagctct ttactgtgag ctc                                  2373


<210>  54
<211>  791
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hSOD1 C6A C111S]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]


<220>
<221>  SIGNAL
<222>  (1)..(22)
<223>  human VK3 leader peptide with 2 additional amino acids to drive 
       correct cleavage

<220>
<221>  MISC_FEATURE
<222>  (23)..(175)
<223>  human SOD1 C6A-C111S without N-terminal methionine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  human SOD 1 C6A amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  human SOD 1 C111S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (176)..(201)
<223>  (gly4ser)4 linker peptide with additional restriction site amino 
       acids

<220>
<221>  MISC_FEATURE
<222>  (202)..(433)
<223>  human IgG1 variant Fc (SSS hinge, P238S, P331S)

<220>
<221>  MISC_FEATURE
<222>  (206)..(206)
<223>  human IgG1 hinge C220S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (212)..(212)
<223>  human IgG1 hinge C226S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (215)..(215)
<223>  human IgG1 hinge C229S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (225)..(225)
<223>  human IgG1 lower hinge-CH2 P238S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (317)..(317)
<223>  human IgG1 Fc P331S amino acid substitution

<220>
<221>  MISC_FEATURE
<222>  (434)..(452)
<223>  peptide linker containing N-linked glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (453)..(791)
<223>  human PON1 Q192K without uncleaved leader peptide

<220>
<221>  MISC_FEATURE
<222>  (628)..(628)
<223>  human PON1 Q192K amino acid substitution

<400>  54

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Ala Ala Thr Lys Ala Val Ala Val Leu Lys Gly 
            20                  25                  30          


Asp Gly Pro Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn 
        35                  40                  45              


Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu 
    50                  55                  60                  


His Gly Phe His Val His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr 
65                  70                  75                  80  


Ser Ala Gly Pro His Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro 
                85                  90                  95      


Lys Asp Glu Glu Arg His Val Gly Asp Leu Gly Asn Val Thr Ala Asp 
            100                 105                 110         


Lys Asp Gly Val Ala Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu 
        115                 120                 125             


Ser Gly Asp His Ser Ile Ile Gly Arg Thr Leu Val Val His Glu Lys 
    130                 135                 140                 


Ala Asp Asp Leu Gly Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly 
145                 150                 155                 160 


Asn Ala Gly Ser Arg Leu Ala Ser Gly Val Ile Gly Ile Ala Gln Asp 
                165                 170                 175     


Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys 
        195                 200                 205             


Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                245                 250                 255     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 430         


Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val 
        435                 440                 445             


Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu 
    450                 455                 460                 


Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu 
465                 470                 475                 480 


Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn 
                485                 490                 495     


Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser 
            500                 505                 510         


Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu 
        515                 520                 525             


Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp 
    530                 535                 540                 


Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp 
545                 550                 555                 560 


Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr 
                565                 570                 575     


Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu 
            580                 585                 590         


Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala 
        595                 600                 605             


Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp 
    610                 615                 620                 


Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr 
625                 630                 635                 640 


Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe 
                645                 650                 655     


Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr 
            660                 665                 670         


Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala 
        675                 680                 685             


Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val 
    690                 695                 700                 


Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys 
705                 710                 715                 720 


His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro 
                725                 730                 735     


Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys 
            740                 745                 750         


Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr 
        755                 760                 765             


Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His 
    770                 775                 780                 


Lys Ala Leu Tyr Cys Glu Leu 
785                 790     


<210>  55
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Peptide linker containing N-linked glycosylation site (NGS 
       linker) DNA

<400>  55
gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatc             54


<210>  56
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker containing N-linked glycosylation site (NGS 
       linker)

<400>  56

Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln 
1               5                   10                  15      


Asp Ile 
        


<210>  57
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  57
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gt                                                           72


<210>  58
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  59
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc] DNA

<400>  59
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttcta ccggtctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      960

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1320

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaa           1614


<210>  60
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]

<400>  60

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535             


<210>  61
<211>  1644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc] DNA

<400>  61
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttctg gaggaggtgg tagtggaggt ggaggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaa                                            1644


<210>  62
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]

<400>  62

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  63
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCTLA-4 EC]-[SSShinge-P238S-P331S Fc] DNA

<400>  63
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccgga taccaccggt       60

gcaatgcacg tggcccagcc tgctgtggta ctggccagca gccgaggcat cgccagcttt      120

gtgtgtgagt atgcatctcc aggcaaagcc actgaggtcc gggtgacagt gcttcggcag      180

gctgacagcc aggtgactga agtctgtgcg gcaacctaca tgatggggaa tgagttgacc      240

ttcctagatg attccatctg cacgggcacc tccagtggaa atcaagtgaa cctcactatc      300

caaggactga gggccatgga cacgggactc tacatctgca aggtggagct catgtaccca      360

ccgccatact acctgggcat aggcaacgga acccagattt atgtaattga tccagaaccg      420

tgcccagatt cagatctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      480

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaataa        1137


<210>  64
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCTLA-4 EC]-[SSShinge-P238S-P331S Fc]

<400>  64

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
            20                  25                  30          


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
        35                  40                  45              


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
    50                  55                  60                  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
                85                  90                  95      


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
            100                 105                 110         


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
        115                 120                 125             


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
    130                 135                 140                 


Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        275                 280                 285             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             


<210>  65
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCTLA-4 EC]-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K] 
       DNA

<400>  65
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccgga taccaccggt       60

gcaatgcacg tggcccagcc tgctgtggta ctggccagca gccgaggcat cgccagcttt      120

gtgtgtgagt atgcatctcc aggcaaagcc actgaggtcc gggtgacagt gcttcggcag      180

gctgacagcc aggtgactga agtctgtgcg gcaacctaca tgatggggaa tgagttgacc      240

ttcctagatg attccatctg cacgggcacc tccagtggaa atcaagtgaa cctcactatc      300

caaggactga gggccatgga cacgggactc tacatctgca aggtggagct catgtaccca      360

ccgccatact acctgggcat aggcaacgga acccagattt atgtaattga tccagaaccg      420

tgcccagatt cagatctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      480

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac      540

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      600

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      660

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg      720

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca      780

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac      840

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc      900

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      960

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1020

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1080

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaagtcgac     1140

ggagctagca gccccgtgaa cgtgagcagc cccagcgtgc aggatatcct cttcaggaac     1200

caccagtctt cttaccaaac acgacttaat gctctccgag aggtacaacc cgtagaactt     1260

cctaactgta atttagttaa aggaatcgaa actggctctg aagacttgga gatactgcct     1320

aatggactgg ctttcattag ctctggatta aagtatcctg gaataaagag cttcaacccc     1380

aacagtcctg gaaaaatact tctgatggac ctgaatgaag aagatccaac agtgttggaa     1440

ttggggatca ctggaagtaa atttgatgta tcttcattta accctcatgg gattagcaca     1500

ttcacagatg aagataatgc catgtacctc ctggtggtga accatccaga tgccaagtcc     1560

acagtggagt tgtttaaatt tcaagaagaa gaaaaatcgc ttttgcatct aaaaaccatc     1620

agacataaac ttctgcctaa tttgaatgat attgttgctg tgggacctga gcacttttat     1680

ggcacaaatg atcactattt tcttgacccc tacttaaaat cctgggagat gtatttgggt     1740

ttagcgtggt cgtatgttgt ctactatagt ccaagtgaag ttcgagtggt ggcagaagga     1800

tttgattttg ctaatggaat caacatttca cccgatggca agtatgtcta tatagctgag     1860

ttgctggctc ataagattca tgtgtatgaa aagcatgcta attggacttt aactccattg     1920

aagtcccttg actttaatac cctcgtggat aacatatctg tggatcctga gacaggagac     1980

ctttgggttg gatgccatcc caatggcatg aaaatcttct tctatgactc agagaatcct     2040

cctgcatcag aggtgcttcg aatccagaac attctaacag aagaacctaa agtgacacag     2100

gtttatgcag aaaatggcac agtgttgcaa ggcagtacag ttgcctctgt gtacaaaggg     2160

aaactgctga ttggcacagt gtttcacaaa gctctttact gtgagctcta a              2211


<210>  66
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCTLA-4 EC]-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  66

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
            20                  25                  30          


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
        35                  40                  45              


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
    50                  55                  60                  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
                85                  90                  95      


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
            100                 105                 110         


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
        115                 120                 125             


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
    130                 135                 140                 


Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        275                 280                 285             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    370                 375                 380                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn 
385                 390                 395                 400 


His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln 
                405                 410                 415     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly 
            420                 425                 430         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        435                 440                 445             


Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly 
    450                 455                 460                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu 
465                 470                 475                 480 


Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His 
                485                 490                 495     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val 
            500                 505                 510         


Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln 
        515                 520                 525             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    530                 535                 540                 


Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
545                 550                 555                 560 


Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu 
                565                 570                 575     


Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser 
            580                 585                 590         


Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        595                 600                 605             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    610                 615                 620                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
625                 630                 635                 640 


Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                645                 650                 655     


Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile 
            660                 665                 670         


Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile 
        675                 680                 685             


Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu 
    690                 695                 700                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly 
705                 710                 715                 720 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                725                 730                 735     


<210>  67
<211>  835
<212>  DNA
<213>  Homo sapiens

<400>  67
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccccaggat cggctgagag ccctggtggt gatccccatc      600

atcttcggga tcctgtttgc catcctcttg gtgctggtct ttatcaaaaa ggtggccaag      660

aagccaacca ataaggcccc ccaccccaag caggaacccc aggagatcaa ttttcccgac      720

gatcttcctg gctccaacac tgctgctcca gtgcaggaga ctttacatgg atgccaaccg      780

gtcacccagg aggatggcaa agagagtcgc atctcagtgc aggagagaca gtgag           835


<210>  68
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  69
<211>  1351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  [hCD40 EC]-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  69
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaata ataatctaga a                                    1351


<210>  70
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hCD40 EC]-(g4s)4-[SSShinge-P238S Fc]

<400>  70

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  71
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 EC]-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  71
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaata a                                               1341


<210>  72
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 EC]-(g4s)4-[SSShinge-P238S Fc]

<400>  72

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  73
<211>  2425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 Q192K] DNA

<400>  73
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1380

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1440

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1500

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1560

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1620

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1680

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1740

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1800

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     1860

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     1920

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     1980

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2040

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2100

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2160

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2220

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2280

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2340

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2400

tactgtgagc tctaataatc tagaa                                           2425


<210>  74
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 Q192K]

<400>  74

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
        435                 440                 445             


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
    450                 455                 460                 


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
465                 470                 475                 480 


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
                485                 490                 495     


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
            500                 505                 510         


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
        515                 520                 525             


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
    530                 535                 540                 


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
545                 550                 555                 560 


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
                565                 570                 575     


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
            580                 585                 590         


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
        595                 600                 605             


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
    610                 615                 620                 


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
625                 630                 635                 640 


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
                645                 650                 655     


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
            660                 665                 670         


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
        675                 680                 685             


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
    690                 695                 700                 


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
705                 710                 715                 720 


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
                725                 730                 735     


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
            740                 745                 750         


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
        755                 760                 765             


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
    770                 775                 780                 


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
785                 790                 795                 800 


Tyr Cys Glu Leu 
                


<210>  75
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81T EC]-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  75
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

acatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaata a                                               1341


<210>  76
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81T EC]-(g4s)4-[SSShinge-P238S Fc]

<400>  76

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Thr Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  77
<211>  2418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81T EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 
       Q192K] DNA

<400>  77
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

acatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1380

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1440

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1500

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1560

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1620

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1680

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1740

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1800

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     1860

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     1920

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     1980

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2040

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2100

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2160

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2220

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2280

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2340

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2400

tactgtgagc tctaataa                                                   2418


<210>  78
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81T EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 
       Q192K]

<400>  78

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Thr Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
        435                 440                 445             


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
    450                 455                 460                 


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
465                 470                 475                 480 


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
                485                 490                 495     


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
            500                 505                 510         


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
        515                 520                 525             


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
    530                 535                 540                 


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
545                 550                 555                 560 


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
                565                 570                 575     


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
            580                 585                 590         


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
        595                 600                 605             


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
    610                 615                 620                 


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
625                 630                 635                 640 


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
                645                 650                 655     


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
            660                 665                 670         


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
        675                 680                 685             


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
    690                 695                 700                 


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
705                 710                 715                 720 


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
                725                 730                 735     


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
            740                 745                 750         


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
        755                 760                 765             


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
    770                 775                 780                 


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
785                 790                 795                 800 


Tyr Cys Glu Leu 
                


<210>  79
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81H-L121P EC]-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  79
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccagg taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

cactactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ccgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaata a                                               1341


<210>  80
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81H-L121P EC]-(g4s)4-[SSShinge-P238S Fc]

<400>  80

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


His Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Pro His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  81
<211>  2415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81H-L121P EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1
       Q192K] DNA

<400>  81
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccagg taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

cactactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ccgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1380

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1440

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1500

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1560

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1620

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1680

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1740

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1800

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     1860

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     1920

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     1980

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2040

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2100

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2160

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2220

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2280

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2340

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2400

tactgtgagc tctaa                                                      2415


<210>  82
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81H-L121P EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1
       Q192K]

<400>  82

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


His Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Pro His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
        435                 440                 445             


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
    450                 455                 460                 


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
465                 470                 475                 480 


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
                485                 490                 495     


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
            500                 505                 510         


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
        515                 520                 525             


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
    530                 535                 540                 


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
545                 550                 555                 560 


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
                565                 570                 575     


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
            580                 585                 590         


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
        595                 600                 605             


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
    610                 615                 620                 


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
625                 630                 635                 640 


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
                645                 650                 655     


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
            660                 665                 670         


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
        675                 680                 685             


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
    690                 695                 700                 


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
705                 710                 715                 720 


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
                725                 730                 735     


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
            740                 745                 750         


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
        755                 760                 765             


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
    770                 775                 780                 


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
785                 790                 795                 800 


Tyr Cys Glu Leu 
                


<210>  83
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81S EC]-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  83
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

tcctactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaata a                                               1341


<210>  84
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81S EC]-(g4s)4-[SSShinge-P238S Fc]

<400>  84

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Ser Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  85
<211>  2415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81S EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 
       Q192K] DNA

<400>  85
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

tcctactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1380

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1440

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1500

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1560

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1620

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1680

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1740

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1800

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     1860

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     1920

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     1980

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2040

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2100

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2160

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2220

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2280

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2340

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2400

tactgtgagc tctaa                                                      2415


<210>  86
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 K81S EC]-(g4s)4-[SSShinge-P238S Fc]-NGS-[PON1 
       Q192K]

<400>  86

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Ser Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
        435                 440                 445             


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
    450                 455                 460                 


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
465                 470                 475                 480 


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
                485                 490                 495     


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
            500                 505                 510         


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
        515                 520                 525             


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
    530                 535                 540                 


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
545                 550                 555                 560 


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
                565                 570                 575     


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
            580                 585                 590         


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
        595                 600                 605             


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
    610                 615                 620                 


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
625                 630                 635                 640 


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
                645                 650                 655     


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
            660                 665                 670         


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
        675                 680                 685             


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
    690                 695                 700                 


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
705                 710                 715                 720 


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
                725                 730                 735     


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
            740                 745                 750         


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
        755                 760                 765             


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
    770                 775                 780                 


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
785                 790                 795                 800 


Tyr Cys Glu Leu 
                


<210>  87
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 E64Y-K81T-P85Y EC]-(g4s)4-[SSShinge-P238S Fc] DNA

<400>  87
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtt acagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

acatactgcg actacaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaata a                                               1341


<210>  88
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 E64Y-K81T-P85Y EC]-(g4s)4-[SSShinge-P238S Fc]

<400>  88

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Tyr 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Thr Tyr Cys Asp Tyr Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  89
<211>  2415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 E64Y-K81T-P85Y EC]-(g4s)4-[SSShinge-P238S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  89
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtt acagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

acatactgcg actacaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccagatctc tccggaggag gtggctcagg tggtggagga      600

tctggaggag gtgggagtgg tggaggtggt tctaccggtc tcgagcccaa atcttctgac      660

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1380

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1440

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1500

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1560

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1620

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1680

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1740

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1800

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     1860

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     1920

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     1980

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2040

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2100

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2160

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2220

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2280

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2340

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2400

tactgtgagc tctaa                                                      2415


<210>  90
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hCD40 E64Y-K81T-P85Y EC]-(g4s)4-[SSShinge-P238S 
       Fc]-NGS-[PON1 Q192K]

<400>  90

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Tyr 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Thr Tyr Cys Asp Tyr Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Asp Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp 
        435                 440                 445             


Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile 
    450                 455                 460                 


Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu 
465                 470                 475                 480 


Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly 
                485                 490                 495     


Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala 
            500                 505                 510         


Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro 
        515                 520                 525             


Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro 
    530                 535                 540                 


Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser 
545                 550                 555                 560 


Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met 
                565                 570                 575     


Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu 
            580                 585                 590         


Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile 
        595                 600                 605             


Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro 
    610                 615                 620                 


Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu 
625                 630                 635                 640 


Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr 
                645                 650                 655     


Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala 
            660                 665                 670         


Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu 
        675                 680                 685             


Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr 
    690                 695                 700                 


Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile 
705                 710                 715                 720 


Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn 
                725                 730                 735     


Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu 
            740                 745                 750         


Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln 
        755                 760                 765             


Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser 
    770                 775                 780                 


Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu 
785                 790                 795                 800 


Tyr Cys Glu Leu 
                


<210>  91
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VL-VH anti-TNFalpha scFv] DNA

<400>  91
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgacatcca gatgacccag tctccatcct ccctgtctgc atctgtaggg      120

gacagagtca ccatcacttg tcgggcaagt cagggcatca gaaattactt agcctggtat      180

cagcaaaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccac tttgcaatca      240

ggggtcccat ctcggttcag tggcagtgga tctgggacag atttcactct caccatcagc      300

agcctacagc ctgaagatgt tgcaacttat tactgtcaaa ggtataaccg tgcaccgtat      360

acttttggcc aggggaccaa ggtggaaatc aaaggaggtg gtggatctgg tggaggaggt      420

tcaggtggtg gaggatctgg gggtggaggt agtgaggtgc agctggtgga gtctggggga      480

ggcttggtac agcccggcag gtccctgaga ctctcctgtg cggcctctgg attcaccttt      540

gatgattatg ccatgcactg ggtccggcaa gctccaggga agggcctgga atgggtctca      600

gctatcactt ggaatagtgg tcacatagac tatgcggact ctgtggaggg ccgattcacc      660

atctccagag acaacgccaa gaactccctg tatctgcaaa tgaacagtct gagagctgag      720

gatacggccg tatattactg tgcgaaagtc tcgtacctta gcaccgcgtc ctcccttgac      780

tattggggcc aaggtaccct ggtcaccgtc tcgtca                                816


<210>  92
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VL-VH anti-TNFalpha scFv]

<400>  92

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn 
            100                 105                 110         


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
        195                 200                 205             


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265             


<210>  93
<211>  2605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VL-VH anti-TNFalpha scFv]-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  93
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgacatcca gatgacccag tctccatcct ccctgtctgc atctgtaggg      120

gacagagtca ccatcacttg tcgggcaagt cagggcatca gaaattactt agcctggtat      180

cagcaaaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccac tttgcaatca      240

ggggtcccat ctcggttcag tggcagtgga tctgggacag atttcactct caccatcagc      300

agcctacagc ctgaagatgt tgcaacttat tactgtcaaa ggtataaccg tgcaccgtat      360

acttttggcc aggggaccaa ggtggaaatc aaaggaggtg gtggatctgg tggaggaggt      420

tcaggtggtg gaggatctgg gggtggaggt agtgaggtgc agctggtgga gtctggggga      480

ggcttggtac agcccggcag gtccctgaga ctctcctgtg cggcctctgg attcaccttt      540

gatgattatg ccatgcactg ggtccggcaa gctccaggga agggcctgga atgggtctca      600

gctatcactt ggaatagtgg tcacatagac tatgcggact ctgtggaggg ccgattcacc      660

atctccagag acaacgccaa gaactccctg tatctgcaaa tgaacagtct gagagctgag      720

gatacggccg tatattactg tgcgaaagtc tcgtacctta gcaccgcgtc ctcccttgac      780

tattggggcc aaggtaccct ggtcaccgtc tcgtcagatc tcgagcccaa atcttctgac      840

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1560

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1620

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1680

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1740

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1800

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1860

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1920

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1980

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     2040

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     2100

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     2160

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2220

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2280

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2340

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2400

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2460

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2520

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2580

tactgtgagc tctaataatc tagaa                                           2605


<210>  94
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VL-VH anti-TNFalpha scFv]-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  94

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn 
            100                 105                 110         


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
        195                 200                 205             


Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Leu Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val 
            500                 505                 510         


Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser 
        515                 520                 525             


Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu 
    530                 535                 540                 


Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu 
545                 550                 555                 560 


Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr 
                565                 570                 575     


Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu 
            580                 585                 590         


Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr 
        595                 600                 605             


Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr 
    610                 615                 620                 


Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro 
625                 630                 635                 640 


Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys 
                645                 650                 655     


Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu 
            660                 665                 670         


Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp 
        675                 680                 685             


His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly 
    690                 695                 700                 


Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val 
705                 710                 715                 720 


Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp 
                725                 730                 735     


Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val 
            740                 745                 750         


Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp 
        755                 760                 765             


Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp 
    770                 775                 780                 


Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp 
785                 790                 795                 800 


Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu 
                805                 810                 815     


Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val 
            820                 825                 830         


Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile 
        835                 840                 845             


Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
    850                 855                 860 


<210>  95
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VH-VL anti-TNFalpha scFv] DNA

<400>  95
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgaggtgca gctggtggag tctgggggag gcttggtaca gcccggcagg      120

tccctgagac tctcctgtgc ggcctctgga ttcacctttg atgattatgc catgcactgg      180

gtccggcaag ctccagggaa gggcctggaa tgggtctcag ctatcacttg gaatagtggt      240

cacatagact atgcggactc tgtggagggc cgattcacca tctccagaga caacgccaag      300

aactccctgt atctgcaaat gaacagtctg agagctgagg atacggccgt atattactgt      360

gcgaaagtct cgtaccttag caccgcgtcc tcccttgact attggggcca aggtaccctg      420

gtcaccgtct cgagtggagg tggtggatct ggtggaggag gttcaggtgg tggaggatct      480

gggggtggag gtagtgacat ccagatgacc cagtctccat cctccctgtc tgcatctgta      540

ggggacagag tcaccatcac ttgtcgggca agtcagggca tcagaaatta cttagcctgg      600

tatcagcaaa aaccagggaa agcccctaag ctcctgatct atgctgcatc cactttgcaa      660

tcaggggtcc catctcggtt cagtggcagt ggatctggga cagatttcac tctcaccatc      720

agcagcctac agcctgaaga tgttgcaact tattactgtc aaaggtataa ccgtgcaccg      780

tatacttttg gccaggggac caaggtggaa atcaaa                                816


<210>  96
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VH-VL anti-TNFalpha scFv]

<400>  96

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            260                 265             


<210>  97
<211>  2605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VH-VL anti-TNFalpha scFv]-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  97
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgaggtgca gctggtggag tctgggggag gcttggtaca gcccggcagg      120

tccctgagac tctcctgtgc ggcctctgga ttcacctttg atgattatgc catgcactgg      180

gtccggcaag ctccagggaa gggcctggaa tgggtctcag ctatcacttg gaatagtggt      240

cacatagact atgcggactc tgtggagggc cgattcacca tctccagaga caacgccaag      300

aactccctgt atctgcaaat gaacagtctg agagctgagg atacggccgt atattactgt      360

gcgaaagtct cgtaccttag caccgcgtcc tcccttgact attggggcca aggtaccctg      420

gtcaccgtct cgagtggagg tggtggatct ggtggaggag gttcaggtgg tggaggatct      480

gggggtggag gtagtgacat ccagatgacc cagtctccat cctccctgtc tgcatctgta      540

ggggacagag tcaccatcac ttgtcgggca agtcagggca tcagaaatta cttagcctgg      600

tatcagcaaa aaccagggaa agcccctaag ctcctgatct atgctgcatc cactttgcaa      660

tcaggggtcc catctcggtt cagtggcagt ggatctggga cagatttcac tctcaccatc      720

agcagcctac agcctgaaga tgttgcaact tattactgtc aaaggtataa ccgtgcaccg      780

tatacttttg gccaggggac caaggtggaa atcaaagatc tcgagcccaa atcttctgac      840

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tctctctctc cgggtaaagt cgacggagct agcagccccg tgaacgtgag cagccccagc     1560

gtgcaggata tcctcttcag gaaccaccag tcttcttacc aaacacgact taatgctctc     1620

cgagaggtac aacccgtaga acttcctaac tgtaatttag ttaaaggaat cgaaactggc     1680

tctgaagact tggagatact gcctaatgga ctggctttca ttagctctgg attaaagtat     1740

cctggaataa agagcttcaa ccccaacagt cctggaaaaa tacttctgat ggacctgaat     1800

gaagaagatc caacagtgtt ggaattgggg atcactggaa gtaaatttga tgtatcttca     1860

tttaaccctc atgggattag cacattcaca gatgaagata atgccatgta cctcctggtg     1920

gtgaaccatc cagatgccaa gtccacagtg gagttgttta aatttcaaga agaagaaaaa     1980

tcgcttttgc atctaaaaac catcagacat aaacttctgc ctaatttgaa tgatattgtt     2040

gctgtgggac ctgagcactt ttatggcaca aatgatcact attttcttga cccctactta     2100

aaatcctggg agatgtattt gggtttagcg tggtcgtatg ttgtctacta tagtccaagt     2160

gaagttcgag tggtggcaga aggatttgat tttgctaatg gaatcaacat ttcacccgat     2220

ggcaagtatg tctatatagc tgagttgctg gctcataaga ttcatgtgta tgaaaagcat     2280

gctaattgga ctttaactcc attgaagtcc cttgacttta ataccctcgt ggataacata     2340

tctgtggatc ctgagacagg agacctttgg gttggatgcc atcccaatgg catgaaaatc     2400

ttcttctatg actcagagaa tcctcctgca tcagaggtgc ttcgaatcca gaacattcta     2460

acagaagaac ctaaagtgac acaggtttat gcagaaaatg gcacagtgtt gcaaggcagt     2520

acagttgcct ctgtgtacaa agggaaactg ctgattggca cagtgtttca caaagctctt     2580

tactgtgagc tctaataatc tagaa                                           2605


<210>  98
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[VH-VL anti-TNFalpha scFv]-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  98

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
            180                 185                 190         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro 
                245                 250                 255     


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Asp Leu Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val 
            500                 505                 510         


Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser 
        515                 520                 525             


Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu 
    530                 535                 540                 


Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu 
545                 550                 555                 560 


Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr 
                565                 570                 575     


Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu 
            580                 585                 590         


Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr 
        595                 600                 605             


Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr 
    610                 615                 620                 


Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro 
625                 630                 635                 640 


Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys 
                645                 650                 655     


Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu 
            660                 665                 670         


Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp 
        675                 680                 685             


His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly 
    690                 695                 700                 


Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val 
705                 710                 715                 720 


Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp 
                725                 730                 735     


Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val 
            740                 745                 750         


Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp 
        755                 760                 765             


Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp 
    770                 775                 780                 


Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp 
785                 790                 795                 800 


Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu 
                805                 810                 815     


Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val 
            820                 825                 830         


Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile 
        835                 840                 845             


Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
    850                 855                 860 


<210>  99
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VH-VL scFv] DNA

<400>  99
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgaagttca gctggtggag tctggcggtg gcctggtgca gccagggggc      120

tcactccgtt tgtcctgtgc agcttctggc tacgcattca ccaactatct gatcgagtgg      180

gtccgtcagg ccccgggtaa gggcctcgag tgggttggtg ttaacaatcc tggatccgga      240

ggctccaact ataacgagaa gttcaagggg cgcgccacta tcagtgcaga caattcgaaa      300

aacacattat acctgcagat gaacagcctg cgtgctgagg acactgccgt ctattattgt      360

gctcgatccg gaggcttcta cttcgactac tggggtcaag gaaccctggt caccgtctcc      420

tcgggaggtg gtggatctgg tggaggaggt tcaggtggtg gaggatctgg gggtggaggt      480

agtgatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc      540

accatcacct gcagagccag tcagagcgtg ctgtatagtt cgaatcagaa gaactacctg      600

gcctggtatc aacagaaacc aggaaaagct ccgaaactac tgatttactg ggctagcact      660

agagaatctg gagtcccttc tcgcttctct ggatccggtt ctgggacgga tttcactctg      720

accatcagca gtctgcagcc agaagacttc gcaacttatt actgtcacca gtatctgagc      780

tctgacacat ttggacaggg taccaaggtg gagatcaaa                             819


<210>  100
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VH-VL scFv]

<400>  100

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Thr Asn Tyr Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Gly Val Asn Asn Pro Gly Ser Gly Gly Ser Asn Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Gly Gly Phe Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser 
                245                 250                 255     


Ser Asp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            260                 265                 


<210>  101
<211>  2608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VH-VL scFv]-SSShinge-P238S-P331S 
       Fc]-NGS-PON1 Q192K] DNA

<400>  101
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgaagttca gctggtggag tctggcggtg gcctggtgca gccagggggc      120

tcactccgtt tgtcctgtgc agcttctggc tacgcattca ccaactatct gatcgagtgg      180

gtccgtcagg ccccgggtaa gggcctcgag tgggttggtg ttaacaatcc tggatccgga      240

ggctccaact ataacgagaa gttcaagggg cgcgccacta tcagtgcaga caattcgaaa      300

aacacattat acctgcagat gaacagcctg cgtgctgagg acactgccgt ctattattgt      360

gctcgatccg gaggcttcta cttcgactac tggggtcaag gaaccctggt caccgtctcc      420

tcgggaggtg gtggatctgg tggaggaggt tcaggtggtg gaggatctgg gggtggaggt      480

agtgatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc      540

accatcacct gcagagccag tcagagcgtg ctgtatagtt cgaatcagaa gaactacctg      600

gcctggtatc aacagaaacc aggaaaagct ccgaaactac tgatttactg ggctagcact      660

agagaatctg gagtcccttc tcgcttctct ggatccggtt ctgggacgga tttcactctg      720

accatcagca gtctgcagcc agaagacttc gcaacttatt actgtcacca gtatctgagc      780

tctgacacat ttggacaggg taccaaggtg gagatcaaag atctcgagcc caaatcttct      840

gacaaaactc acacatctcc accgtcccca gcacctgaac tcctgggagg atcgtcagtc      900

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      960

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1020

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1080

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1140

tgcaaggtct ccaacaaagc cctcccagcc tccatcgaga aaaccatctc caaagccaaa     1200

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1260

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1320

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1380

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1440

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1500

ctctctctct ctccgggtaa agtcgacgga gctagcagcc ccgtgaacgt gagcagcccc     1560

agcgtgcagg atatcctctt caggaaccac cagtcttctt accaaacacg acttaatgct     1620

ctccgagagg tacaacccgt agaacttcct aactgtaatt tagttaaagg aatcgaaact     1680

ggctctgaag acttggagat actgcctaat ggactggctt tcattagctc tggattaaag     1740

tatcctggaa taaagagctt caaccccaac agtcctggaa aaatacttct gatggacctg     1800

aatgaagaag atccaacagt gttggaattg gggatcactg gaagtaaatt tgatgtatct     1860

tcatttaacc ctcatgggat tagcacattc acagatgaag ataatgccat gtacctcctg     1920

gtggtgaacc atccagatgc caagtccaca gtggagttgt ttaaatttca agaagaagaa     1980

aaatcgcttt tgcatctaaa aaccatcaga cataaacttc tgcctaattt gaatgatatt     2040

gttgctgtgg gacctgagca cttttatggc acaaatgatc actattttct tgacccctac     2100

ttaaaatcct gggagatgta tttgggttta gcgtggtcgt atgttgtcta ctatagtcca     2160

agtgaagttc gagtggtggc agaaggattt gattttgcta atggaatcaa catttcaccc     2220

gatggcaagt atgtctatat agctgagttg ctggctcata agattcatgt gtatgaaaag     2280

catgctaatt ggactttaac tccattgaag tcccttgact ttaataccct cgtggataac     2340

atatctgtgg atcctgagac aggagacctt tgggttggat gccatcccaa tggcatgaaa     2400

atcttcttct atgactcaga gaatcctcct gcatcagagg tgcttcgaat ccagaacatt     2460

ctaacagaag aacctaaagt gacacaggtt tatgcagaaa atggcacagt gttgcaaggc     2520

agtacagttg cctctgtgta caaagggaaa ctgctgattg gcacagtgtt tcacaaagct     2580

ctttactgtg agctctaata atctagaa                                        2608


<210>  102
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VH-VL scFv]-SSShinge-P238S-P331S 
       Fc]-NGS-PON1 Q192K]

<400>  102

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Thr Asn Tyr Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Gly Val Asn Asn Pro Gly Ser Gly Gly Ser Asn Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Gly Gly Phe Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln 
            180                 185                 190         


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser 
                245                 250                 255     


Ser Asp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Asp Leu Glu 
            260                 265                 270         


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn 
            500                 505                 510         


Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser 
        515                 520                 525             


Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu 
    530                 535                 540                 


Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp 
545                 550                 555                 560 


Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys 
                565                 570                 575     


Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu 
            580                 585                 590         


Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile 
        595                 600                 605             


Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser 
    610                 615                 620                 


Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His 
625                 630                 635                 640 


Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu 
                645                 650                 655     


Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn 
            660                 665                 670         


Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn 
        675                 680                 685             


Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu 
    690                 695                 700                 


Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg 
705                 710                 715                 720 


Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro 
                725                 730                 735     


Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His 
            740                 745                 750         


Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu 
        755                 760                 765             


Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly 
    770                 775                 780                 


Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr 
785                 790                 795                 800 


Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile 
                805                 810                 815     


Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr 
            820                 825                 830         


Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu 
        835                 840                 845             


Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
    850                 855                 860     


<210>  103
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VL-VH scFv] DNA

<400>  103
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgatatcca gatgacccag tccccgagct ccctgtccgc ctctgtgggc      120

gatagggtca ccatcacctg cagagccagt cagagcgtgc tgtatagttc gaatcagaag      180

aactacctgg cctggtatca acagaaacca ggaaaagctc cgaaactact gatttactgg      240

gctagcacta gagaatctgg agtcccttct cgcttctctg gatccggttc tgggacggat      300

ttcactctga ccatcagcag tctgcagcca gaagacttcg caacttatta ctgtcaccag      360

tatctgagct ctgacacatt tggacagggt accaaggtgg agatcaaagg aggtggtgga      420

tctggtggag gaggttcagg tggtggagga tctgggggtg gaggtagtga agttcagctg      480

gtggagtctg gcggtggcct ggtgcagcca gggggctcac tccgtttgtc ctgtgcagct      540

tctggctacg cattcaccaa ctatctgatc gagtgggtcc gtcaggcccc gggtaagggc      600

ctcgagtggg ttggtgttaa caatcctgga tccggaggct ccaactataa cgagaagttc      660

aaggggcgcg ccactatcag tgcagacaat tcgaaaaaca cattatacct gcagatgaac      720

agcctgcgtg ctgaggacac tgccgtctat tattgtgctc gatccggagg cttctacttc      780

gactactggg gtcaaggaac cctggtcacc gtctcctcg                             819


<210>  104
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VL-VH scFv]

<400>  104

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys His Gln Tyr Leu Ser Ser Asp Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Gly Val Asn Asn Pro Gly Ser Gly 
        195                 200                 205             


Gly Ser Asn Tyr Asn Glu Lys Phe Lys Gly Arg Ala Thr Ile Ser Ala 
    210                 215                 220                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Phe Tyr Phe 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265                 


<210>  105
<211>  2608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VL-VH scFv]-SSShinge-P238S-P331S 
       Fc]-NGS-PON1 Q192K] DNA

<400>  105
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctcccg       60

gataccaccg gtgatatcca gatgacccag tccccgagct ccctgtccgc ctctgtgggc      120

gatagggtca ccatcacctg cagagccagt cagagcgtgc tgtatagttc gaatcagaag      180

aactacctgg cctggtatca acagaaacca ggaaaagctc cgaaactact gatttactgg      240

gctagcacta gagaatctgg agtcccttct cgcttctctg gatccggttc tgggacggat      300

ttcactctga ccatcagcag tctgcagcca gaagacttcg caacttatta ctgtcaccag      360

tatctgagct ctgacacatt tggacagggt accaaggtgg agatcaaagg aggtggtgga      420

tctggtggag gaggttcagg tggtggagga tctgggggtg gaggtagtga agttcagctg      480

gtggagtctg gcggtggcct ggtgcagcca gggggctcac tccgtttgtc ctgtgcagct      540

tctggctacg cattcaccaa ctatctgatc gagtgggtcc gtcaggcccc gggtaagggc      600

ctcgagtggg ttggtgttaa caatcctgga tccggaggct ccaactataa cgagaagttc      660

aaggggcgcg ccactatcag tgcagacaat tcgaaaaaca cattatacct gcagatgaac      720

agcctgcgtg ctgaggacac tgccgtctat tattgtgctc gatccggagg cttctacttc      780

gactactggg gtcaaggaac cctggtcacc gtctcctcag atctcgagcc caaatcttct      840

gacaaaactc acacatctcc accgtcccca gcacctgaac tcctgggagg atcgtcagtc      900

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      960

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1020

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1080

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1140

tgcaaggtct ccaacaaagc cctcccagcc tccatcgaga aaaccatctc caaagccaaa     1200

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1260

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1320

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1380

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1440

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1500

ctctctctct ctccgggtaa agtcgacgga gctagcagcc ccgtgaacgt gagcagcccc     1560

agcgtgcagg atatcctctt caggaaccac cagtcttctt accaaacacg acttaatgct     1620

ctccgagagg tacaacccgt agaacttcct aactgtaatt tagttaaagg aatcgaaact     1680

ggctctgaag acttggagat actgcctaat ggactggctt tcattagctc tggattaaag     1740

tatcctggaa taaagagctt caaccccaac agtcctggaa aaatacttct gatggacctg     1800

aatgaagaag atccaacagt gttggaattg gggatcactg gaagtaaatt tgatgtatct     1860

tcatttaacc ctcatgggat tagcacattc acagatgaag ataatgccat gtacctcctg     1920

gtggtgaacc atccagatgc caagtccaca gtggagttgt ttaaatttca agaagaagaa     1980

aaatcgcttt tgcatctaaa aaccatcaga cataaacttc tgcctaattt gaatgatatt     2040

gttgctgtgg gacctgagca cttttatggc acaaatgatc actattttct tgacccctac     2100

ttaaaatcct gggagatgta tttgggttta gcgtggtcgt atgttgtcta ctatagtcca     2160

agtgaagttc gagtggtggc agaaggattt gattttgcta atggaatcaa catttcaccc     2220

gatggcaagt atgtctatat agctgagttg ctggctcata agattcatgt gtatgaaaag     2280

catgctaatt ggactttaac tccattgaag tcccttgact ttaataccct cgtggataac     2340

atatctgtgg atcctgagac aggagacctt tgggttggat gccatcccaa tggcatgaaa     2400

atcttcttct atgactcaga gaatcctcct gcatcagagg tgcttcgaat ccagaacatt     2460

ctaacagaag aacctaaagt gacacaggtt tatgcagaaa atggcacagt gttgcaaggc     2520

agtacagttg cctctgtgta caaagggaaa ctgctgattg gcacagtgtt tcacaaagct     2580

ctttactgtg agctctaata atctagaa                                        2608


<210>  106
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[anti-hTGFbeta VL-VH scFv]-SSShinge-P238S-P331S 
       Fc]-NGS-PON1 Q192K]

<400>  106

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys His Gln Tyr Leu Ser Ser Asp Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Gly Val Asn Asn Pro Gly Ser Gly 
        195                 200                 205             


Gly Ser Asn Tyr Asn Glu Lys Phe Lys Gly Arg Ala Thr Ile Ser Ala 
    210                 215                 220                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Gly Phe Tyr Phe 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Leu Glu 
            260                 265                 270         


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn 
            500                 505                 510         


Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser 
        515                 520                 525             


Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu 
    530                 535                 540                 


Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp 
545                 550                 555                 560 


Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys 
                565                 570                 575     


Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu 
            580                 585                 590         


Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile 
        595                 600                 605             


Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser 
    610                 615                 620                 


Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His 
625                 630                 635                 640 


Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu 
                645                 650                 655     


Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn 
            660                 665                 670         


Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn 
        675                 680                 685             


Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu 
    690                 695                 700                 


Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg 
705                 710                 715                 720 


Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro 
                725                 730                 735     


Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His 
            740                 745                 750         


Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu 
        755                 760                 765             


Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly 
    770                 775                 780                 


Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr 
785                 790                 795                 800 


Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile 
                805                 810                 815     


Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr 
            820                 825                 830         


Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu 
        835                 840                 845             


Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
    850                 855                 860     


<210>  107
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  107
gataccaccg gtgaggtgca gctggtggag tctgggggag gcttggtaca gcccggcagg       60

tccctgagac tctcctgtgc ggcctctgga ttcacctttg atgattatgc catgcactgg      120

gtccggcaag ctccagggaa gggcctggaa tgggtctcag ctatcacttg gaatagtggt      180

cacatagact atgcggactc tgtggagggc cgattcacca tctccagaga caacgccaag      240

aactccctgt atctgcaaat gaacagtctg agagctgagg atacggccgt atattactgt      300

gcgaaagtct cgtaccttag caccgcgtcc tcccttgact attggggcca aggtaccctg      360

gtc                                                                    363


<210>  108
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  109
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  109
gataccaccg gtgacatcca gatgacccag tctccatcct ccctgtctgc atctgtaggg       60

gacagagtca ccatcacttg tcgggcaagt cagggcatca gaaattactt agcctggtat      120

cagcaaaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccac tttgcaatca      180

ggggtcccat ctcggttcag tggcagtgga tctgggacag atttcactct caccatcagc      240

agcctacagc ctgaagatgt tgcaacttat tactgtcaaa ggtataaccg tgcaccgtat      300

acttttggcc aggggaccaa g                                                321


<210>  110
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  111
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-hTGFbeta VH DNA

<400>  111
gataccaccg gtgaagttca gctggtggag tctggcggtg gcctggtgca gccagggggc       60

tcactccgtt tgtcctgtgc agcttctggc tacgcattca ccaactatct gatcgagtgg      120

gtccgtcagg ccccgggtaa gggcctcgag tgggttggtg ttaacaatcc tggatccgga      180

ggctccaact ataacgagaa gttcaagggg cgcgccacta tcagtgcaga caattcgaaa      240

aacacattat acctgcagat gaacagcctg cgtgctgagg acactgccgt ctattattgt      300

gctcgatccg gaggcttcta cttcgactac tggggtcaag gaaccctggt c               351


<210>  112
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-hTGFbeta VH

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Asn Asn Pro Gly Ser Gly Gly Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  113
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized anti-hTGFbeta VL DNA

<400>  113
gataccaccg gtgatatcca gatgacccag tccccgagct ccctgtccgc ctctgtgggc       60

gatagggtca ccatcacctg cagagccagt cagagcgtgc tgtatagttc gaatcagaag      120

aactacctgg cctggtatca acagaaacca ggaaaagctc cgaaactact gatttactgg      180

gctagcacta gagaatctgg agtcccttct cgcttctctg gatccggttc tgggacggat      240

ttcactctga ccatcagcag tctgcagcca gaagacttcg caacttatta ctgtcaccag      300

tatctgagct ctgacacatt tggacagggt accaag                                336


<210>  114
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized anti-hTGFbeta VL

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Asp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  115
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SCC hinge, P238S, P331S)

<400>  115
gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg       60

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctctctccg ggtaaa                                696


<210>  116
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc (SCC hinge, P238S, P331S)

<400>  116

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  117
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc DNA (SCC hinge, P238S)

<400>  117
gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg       60

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc tctctctccg ggtaaa                                696


<210>  118
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 variant Fc (SCC hinge, P238S)

<400>  118

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (gly4ser) tandem repeat sequence

<400>  119

Gly Gly Gly Gly Ser 
1               5   


<210>  120
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  120

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys 
            260 


<210>  121
<211>  1842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[PON1 Q192K] DNA

<400>  121
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaagatctcg agcccaaatc ttctgacaaa actcacacat gtccaccgtg cccagcacct      120

gaactcctgg gaggatcgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcctccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctct ctctctccgg gtaaagtcga cggagctagc      780

agccccgtga acgtgagcag ccccagcgtg caggatatcc tcttcaggaa ccaccagtct      840

tcttaccaaa cacgacttaa tgctctccga gaggtacaac ccgtagaact tcctaactgt      900

aatttagtta aaggaatcga aactggctct gaagacttgg agatactgcc taatggactg      960

gctttcatta gctctggatt aaagtatcct ggaataaaga gcttcaaccc caacagtcct     1020

ggaaaaatac ttctgatgga cctgaatgaa gaagatccaa cagtgttgga attggggatc     1080

actggaagta aatttgatgt atcttcattt aaccctcatg ggattagcac attcacagat     1140

gaagataatg ccatgtacct cctggtggtg aaccatccag atgccaagtc cacagtggag     1200

ttgtttaaat ttcaagaaga agaaaaatcg cttttgcatc taaaaaccat cagacataaa     1260

cttctgccta atttgaatga tattgttgct gtgggacctg agcactttta tggcacaaat     1320

gatcactatt ttcttgaccc ctacttaaaa tcctgggaga tgtatttggg tttagcgtgg     1380

tcgtatgttg tctactatag tccaagtgaa gttcgagtgg tggcagaagg atttgatttt     1440

gctaatggaa tcaacatttc acccgatggc aagtatgtct atatagctga gttgctggct     1500

cataagattc atgtgtatga aaagcatgct aattggactt taactccatt gaagtccctt     1560

gactttaata ccctcgtgga taacatatct gtggatcctg agacaggaga cctttgggtt     1620

ggatgccatc ccaatggcat gaaaatcttc ttctatgact cagagaatcc tcctgcatca     1680

gaggtgcttc gaatccagaa cattctaaca gaagaaccta aagtgacaca ggtttatgca     1740

gaaaatggca cagtgttgca aggcagtaca gttgcctctg tgtacaaagg gaaactgctg     1800

attggcacag tgtttcacaa agctctttac tgtgagctct aa                        1842


<210>  122
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  122

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
                245                 250                 255     


Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp 
            260                 265                 270         


Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala 
        275                 280                 285             


Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys 
    290                 295                 300                 


Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn 
                325                 330                 335     


Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp 
            340                 345                 350         


Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser 
        355                 360                 365             


Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala 
    370                 375                 380                 


Met Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu 
385                 390                 395                 400 


Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr 
                405                 410                 415     


Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly 
            420                 425                 430         


Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr 
        435                 440                 445             


Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val 
    450                 455                 460                 


Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe 
465                 470                 475                 480 


Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala 
                485                 490                 495     


Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp 
            500                 505                 510         


Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn 
        515                 520                 525             


Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro 
    530                 535                 540                 


Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser 
545                 550                 555                 560 


Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr 
                565                 570                 575     


Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala 
            580                 585                 590         


Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala 
        595                 600                 605             


Leu Tyr Cys Glu Leu 
    610             


<210>  123
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PON1 variant G3C9 DNA

<400>  123
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggattaaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaacc atccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcct gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gattttgcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt gttacagggc agcacggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctg                     1065


<210>  124
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PON1 variant G3C9

<400>  124

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  125
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PON1 variant M-IIG1 DNA

<400>  125
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acattgaaat actgcccaat      180

ggactggctt tcatcagctc cggagttaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgctgggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaacc gaccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcct gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga ttattctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt gttacagggc agcagtgtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctg                     1065


<210>  126
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PON1 variant M-IIG1

<400>  126

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  127
<211>  2713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[G3C9 PON1] DNA

<400>  127
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc attcattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc taccggtctc gagcccaaat cttctgacaa aactcacaca      960

tctccaccgt ccccagcacc tgaactcctg ggaggatcgt cagtcttcct cttcccccca     1020

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1080

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1140

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1200

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1260

aaagccctcc cagcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1320

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1380

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1440

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1500

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1560

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctctctccg     1620

ggtaaagtcg acggagctag cagccccgtg aacgtgagca gccccagcgt gcaggatatc     1680

ctcttcgatg gacagaagtc ttctttccaa acacgattta atgttcaccg tgaagtaact     1740

ccagtggaac ttcctaactg taatttagtt aaaggggttg acaatggttc tgaagacttg     1800

gaaatactgc ccaatggact ggctttcatc agctccggat taaagtatcc tggaataatg     1860

agctttgacc ctgataagtc tggaaagata cttctaatgg acctgaatga ggaagaccca     1920

gtagtgttgg aactgggcat tactggaaat acattggata tatcttcatt taaccctcat     1980

gggattagca cattcacaga tgaagataac actgtgtacc tactggtggt aaaccatcca     2040

gactcctcgt ccaccgtgga ggtgtttaaa tttcaagaag aagaaaaatc acttttgcat     2100

ctgaaaacca tcagacacaa gcttctgcct agtgtgaatg acattgtcgc tgtgggacct     2160

gaacactttt atgccacaaa tgatcactat tttgctgacc cttacttaaa atcctgggaa     2220

atgcatttgg gattagcgtg gtcatttgtt acttattata gtcccaatga tgttcgagta     2280

gtggcagaag gatttgattt tgctaacgga atcaacatct caccagacgg caagtatgtc     2340

tatatagctg agttgctggc tcataagatc catgtgtatg aaaagcacgc taattggact     2400

ttaactccat tgaagtccct cgactttgac acccttgtgg ataacatctc tgtggatcct     2460

gtgacagggg acctctgggt gggatgccat cccaacggaa tgcgaatctt ctactatgac     2520

ccaaagaatc ctcccggctc agaggtgctt cgaatccagg acattttatc cgaagagccc     2580

aaagtgacag tggtttatgc agaaaatggc actgtgttac agggcagcac ggtggccgct     2640

gtgtacaaag ggaaactgct gattggcaca gtgtttcaca aagctcttta ctgtgagctg     2700

taataatcta gaa                                                        2713


<210>  128
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[G3C9 PON1]

<400>  128

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Asp Gly 
545                 550                 555                 560 


Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu Val Thr 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp Asn Gly 
            580                 585                 590         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys Ser Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn Pro His 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu Leu Val 
            660                 665                 670         


Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser Pro Asn 
            740                 745                 750         


Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Arg Ile 
            820                 825                 830         


Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  129
<211>  2688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[M-IIG1 PON1] DNA

<400>  129
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttcta ccggtctcga gcccaaatct tctgacaaaa ctcacacatc tccaccgtcc      960

ccagcacctg aactcctggg aggatcgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1320

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctctc tctctccggg taaagtcgac     1620

ggagctagca gccccgtgaa cgtgagcagc cccagcgtgc aggatatcct cttcgatgga     1680

cagaagtctt ctttccaaac acgatttaat gttcaccgtg aagtaactcc agtggaactt     1740

cctaactgta atttagttaa aggggttgac aatggttctg aagacattga aatactgccc     1800

aatggactgg ctttcatcag ctccggagtt aagtatcctg gaataatgag ctttgaccct     1860

gataagtctg gaaagatact tctaatggac ctgaatgagg aagacccagt agtgttggaa     1920

ctgggcatta ctggaaatac attggatata tcttcattta accctgctgg gattagcaca     1980

ttcacagatg aagataacac tgtgtaccta ctggtggtaa accgaccaga ctcctcgtcc     2040

accgtggagg tgtttaaatt tcaagaagaa gaaaaatcac ttttgcatct gaaaaccatc     2100

agacacaagc ttctgcctag tgtgaatgac attgtcgctg tgggacctga acacttttat     2160

gccacaaatg atcactattt tgctgaccct tacttaaaat cctgggaaat gcatttggga     2220

ttagcgtggt catttgttac ttattatagt cccaatgatg ttcgagtagt ggcagaagga     2280

tttgatatgg ctaacggaat caacatctca ccagacggca agtatgtcta tatagctgag     2340

ttgctggctc ataagatcca tgtgtatgaa aagcacgcta attggacttt aactccattg     2400

aagtccctcg actttgacac ccttgtggat aacatctctg tggatcctgt gacaggggac     2460

ctctgggtgg gatgccatcc caacggaatg cgattattct actatgaccc aaagaatcct     2520

cccggctcag aggtgcttcg aatccaggac attttatccg aagagcccaa agtgacagtg     2580

gtttatgcag aaaatggcac tgtgttacag ggcagcagtg tggccgctgt gtacaaaggg     2640

aaactgctga ttggcacagt gtttcacaaa gctctttact gtgagctg                  2688


<210>  130
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[M-IIG1 PON1]

<400>  130

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Asp Gly 
545                 550                 555                 560 


Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu Val Thr 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp Asn Gly 
            580                 585                 590         


Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys Ser Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn Pro Ala 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu Leu Val 
            660                 665                 670         


Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser Pro Asn 
            740                 745                 750         


Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Arg Leu 
            820                 825                 830         


Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  131
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[G3C9 PON1] DNA

<400>  131
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaagatctcg agcccaaatc ttctgacaaa actcacacat gtccaccgtg cccagcacct      120

gaactcctgg gaggatcgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcctccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctct ctctctccgg gtaaagtcga cggagctagc      780

agccccgtga acgtgagcag ccccagcgtg caggatatcc tcttcgatgg acagaagtct      840

tctttccaaa cacgatttaa tgttcaccgt gaagtaactc cagtggaact tcctaactgt      900

aatttagtta aaggggttga caatggttct gaagacttgg aaatactgcc caatggactg      960

gctttcatca gctccggatt aaagtatcct ggaataatga gctttgaccc tgataagtct     1020

ggaaagatac ttctaatgga cctgaatgag gaagacccag tagtgttgga actgggcatt     1080

actggaaata cattggatat atcttcattt aaccctcatg ggattagcac attcacagat     1140

gaagataaca ctgtgtacct actggtggta aaccatccag actcctcgtc caccgtggag     1200

gtgtttaaat ttcaagaaga agaaaaatca cttttgcatc tgaaaaccat cagacacaag     1260

cttctgccta gtgtgaatga cattgtcgct gtgggacctg aacactttta tgccacaaat     1320

gatcactatt ttgctgaccc ttacttaaaa tcctgggaaa tgcatttggg attagcgtgg     1380

tcatttgtta cttattatag tcccaatgat gttcgagtag tggcagaagg atttgatttt     1440

gctaacggaa tcaacatctc accagacggc aagtatgtct atatagctga gttgctggct     1500

cataagatcc atgtgtatga aaagcacgct aattggactt taactccatt gaagtccctc     1560

gactttgaca cccttgtgga taacatctct gtggatcctg tgacagggga cctctgggtg     1620

ggatgccatc ccaacggaat gcgaatcttc tactatgacc caaagaatcc tcccggctca     1680

gaggtgcttc gaatccagga cattttatcc gaagagccca aagtgacagt ggtttatgca     1740

gaaaatggca ctgtgttaca gggcagcacg gtggccgctg tgtacaaagg gaaactgctg     1800

attggcacag tgtttcacaa agctctttac tgtgagctg                            1839


<210>  132
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[G3C9 PON1]

<400>  132

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
                245                 250                 255     


Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp 
            260                 265                 270         


Ile Leu Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val 
        275                 280                 285             


His Arg Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys 
    290                 295                 300                 


Gly Val Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp 
                325                 330                 335     


Pro Asp Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp 
            340                 345                 350         


Pro Val Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser 
        355                 360                 365             


Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr 
    370                 375                 380                 


Val Tyr Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu 
385                 390                 395                 400 


Val Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr 
                405                 410                 415     


Ile Arg His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly 
            420                 425                 430         


Pro Glu His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr 
        435                 440                 445             


Leu Lys Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr 
    450                 455                 460                 


Tyr Tyr Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe 
465                 470                 475                 480 


Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala 
                485                 490                 495     


Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp 
            500                 505                 510         


Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn 
        515                 520                 525             


Ile Ser Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro 
    530                 535                 540                 


Asn Gly Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser 
545                 550                 555                 560 


Glu Val Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr 
                565                 570                 575     


Val Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala 
            580                 585                 590         


Ala Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala 
        595                 600                 605             


Leu Tyr Cys Glu Leu 
    610             


<210>  133
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[M-IIG1 PON1] DNA

<400>  133
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

aaagatctcg agcccaaatc ttctgacaaa actcacacat gtccaccgtg cccagcacct      120

gaactcctgg gaggatcgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      180

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      240

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      300

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      360

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcctccatc      420

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      480

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      540

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      600

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg      660

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      720

cacaaccact acacgcagaa gagcctctct ctctctccgg gtaaagtcga cggagctagc      780

agccccgtga acgtgagcag ccccagcgtg caggatatcc tcttcgatgg acagaagtct      840

tctttccaaa cacgatttaa tgttcaccgt gaagtaactc cagtggaact tcctaactgt      900

aatttagtta aaggggttga caatggttct gaagacattg aaatactgcc caatggactg      960

gctttcatca gctccggagt taagtatcct ggaataatga gctttgaccc tgataagtct     1020

ggaaagatac ttctaatgga cctgaatgag gaagacccag tagtgttgga actgggcatt     1080

actggaaata cattggatat atcttcattt aaccctgctg ggattagcac attcacagat     1140

gaagataaca ctgtgtacct actggtggta aaccgaccag actcctcgtc caccgtggag     1200

gtgtttaaat ttcaagaaga agaaaaatca cttttgcatc tgaaaaccat cagacacaag     1260

cttctgccta gtgtgaatga cattgtcgct gtgggacctg aacactttta tgccacaaat     1320

gatcactatt ttgctgaccc ttacttaaaa tcctgggaaa tgcatttggg attagcgtgg     1380

tcatttgtta cttattatag tcccaatgat gttcgagtag tggcagaagg atttgatatg     1440

gctaacggaa tcaacatctc accagacggc aagtatgtct atatagctga gttgctggct     1500

cataagatcc atgtgtatga aaagcacgct aattggactt taactccatt gaagtccctc     1560

gactttgaca cccttgtgga taacatctct gtggatcctg tgacagggga cctctgggtg     1620

ggatgccatc ccaacggaat gcgattattc tactatgacc caaagaatcc tcccggctca     1680

gaggtgcttc gaatccagga cattttatcc gaagagccca aagtgacagt ggtttatgca     1740

gaaaatggca ctgtgttaca gggcagcagt gtggccgctg tgtacaaagg gaaactgctg     1800

attggcacag tgtttcacaa agctctttac tgtgagctg                            1839


<210>  134
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[KDL-SCChinge-P238S-P331S Fc]-NGS-[M-IIG1 PON1]

<400>  134

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Lys Asp Leu Glu Pro Lys Ser Ser Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val 
                245                 250                 255     


Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp 
            260                 265                 270         


Ile Leu Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val 
        275                 280                 285             


His Arg Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys 
    290                 295                 300                 


Gly Val Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp 
                325                 330                 335     


Pro Asp Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp 
            340                 345                 350         


Pro Val Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser 
        355                 360                 365             


Ser Phe Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr 
    370                 375                 380                 


Val Tyr Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu 
385                 390                 395                 400 


Val Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr 
                405                 410                 415     


Ile Arg His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly 
            420                 425                 430         


Pro Glu His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr 
        435                 440                 445             


Leu Lys Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr 
    450                 455                 460                 


Tyr Tyr Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met 
465                 470                 475                 480 


Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala 
                485                 490                 495     


Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp 
            500                 505                 510         


Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn 
        515                 520                 525             


Ile Ser Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro 
    530                 535                 540                 


Asn Gly Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser 
545                 550                 555                 560 


Glu Val Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr 
                565                 570                 575     


Val Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala 
            580                 585                 590         


Ala Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala 
        595                 600                 605             


Leu Tyr Cys Glu Leu 
    610             


<210>  135
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  135
atgtcacggg agctggcccc actgctgctt ctcctcctct ccatccacag cgccctggcc       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcaagg      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagaaacac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaacagc aaaaaatctg tcactctaag gaagaaaaca      900

aagaggaaac gctcctaccc aactttcttg tacaaagttg gcattataag aaagcattgc      960

ttatcaattt gttgcaacga ac                                               982


<210>  136
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Arg Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  137
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutAAA, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc] DNA

<400>  137
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcagca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gagcagctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaataa                                         1647


<210>  138
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutAAA, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]

<400>  138

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ala 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ala Ala 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  139
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutSSS, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc] DNA

<400>  139
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcatca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagttctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaataa                                         1647


<210>  140
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 NLS1mutSSS, 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]

<400>  140

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ser 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ser Ser 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  141
<211>  1842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[PON1 Q192K] DNA

<400>  141
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg      120

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc tctctctccg ggtaaagtcg acggagctag cagccccgtg      780

aacgtgagca gccccagcgt gcaggatatc ctcttcagga accaccagtc ttcttaccaa      840

acacgactta atgctctccg agaggtacaa cccgtagaac ttcctaactg taatttagtt      900

aaaggaatcg aaactggctc tgaagacttg gagatactgc ctaatggact ggctttcatt      960

agctctggat taaagtatcc tggaataaag agcttcaacc ccaacagtcc tggaaaaata     1020

cttctgatgg acctgaatga agaagatcca acagtgttgg aattggggat cactggaagt     1080

aaatttgatg tatcttcatt taaccctcat gggattagca cattcacaga tgaagataat     1140

gccatgtacc tcctggtggt gaaccatcca gatgccaagt ccacagtgga gttgtttaaa     1200

tttcaagaag aagaaaaatc gcttttgcat ctaaaaacca tcagacataa acttctgcct     1260

aatttgaatg atattgttgc tgtgggacct gagcactttt atggcacaaa tgatcactat     1320

tttcttgacc cctacttaaa atcctgggag atgtatttgg gtttagcgtg gtcgtatgtt     1380

gtctactata gtccaagtga agttcgagtg gtggcagaag gatttgattt tgctaatgga     1440

atcaacattt cacccgatgg caagtatgtc tatatagctg agttgctggc tcataagatt     1500

catgtgtatg aaaagcatgc taattggact ttaactccat tgaagtccct tgactttaat     1560

accctcgtgg ataacatatc tgtggatcct gagacaggag acctttgggt tggatgccat     1620

cccaatggca tgaaaatctt cttctatgac tcagagaatc ctcctgcatc agaggtgctt     1680

cgaatccaga acattctaac agaagaacct aaagtgacac aggtttatgc agaaaatggc     1740

acagtgttgc aaggcagtac agttgcctct gtgtacaaag ggaaactgct gattggcaca     1800

gtgtttcaca aagctcttta ctgtgagctc taataatcta ga                        1842


<210>  142
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  142

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
                245                 250                 255     


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
            260                 265                 270         


Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu 
        275                 280                 285             


Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu 
    290                 295                 300                 


Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
305                 310                 315                 320 


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser 
                325                 330                 335     


Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val 
            340                 345                 350         


Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn 
        355                 360                 365             


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu 
    370                 375                 380                 


Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys 
385                 390                 395                 400 


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
                405                 410                 415     


Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His 
            420                 425                 430         


Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser 
        435                 440                 445             


Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser 
    450                 455                 460                 


Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly 
465                 470                 475                 480 


Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu 
                485                 490                 495     


Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr 
            500                 505                 510         


Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val 
        515                 520                 525             


Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met 
    530                 535                 540                 


Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu 
545                 550                 555                 560 


Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr 
                565                 570                 575     


Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr 
            580                 585                 590         


Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  143
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[G3C9 PON1] DNA

<400>  143
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg      120

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc tctctctccg ggtaaagtcg acggagctag cagccccgtg      780

aacgtgagca gccccagcgt gcaggatatc ctcttcgatg gacagaagtc ttctttccaa      840

acacgattta atgttcaccg tgaagtaact ccagtggaac ttcctaactg taatttagtt      900

aaaggggttg acaatggttc tgaagacttg gaaatactgc ccaatggact ggctttcatc      960

agctccggat taaagtatcc tggaataatg agctttgacc ctgataagtc tggaaagata     1020

cttctaatgg acctgaatga ggaagaccca gtagtgttgg aactgggcat tactggaaat     1080

acattggata tatcttcatt taaccctcat gggattagca cattcacaga tgaagataac     1140

actgtgtacc tactggtggt aaaccatcca gactcctcgt ccaccgtgga ggtgtttaaa     1200

tttcaagaag aagaaaaatc acttttgcat ctgaaaacca tcagacacaa gcttctgcct     1260

agtgtgaatg acattgtcgc tgtgggacct gaacactttt atgccacaaa tgatcactat     1320

tttgctgacc cttacttaaa atcctgggaa atgcatttgg gattagcgtg gtcatttgtt     1380

acttattata gtcccaatga tgttcgagta gtggcagaag gatttgattt tgctaacgga     1440

atcaacatct caccagacgg caagtatgtc tatatagctg agttgctggc tcataagatc     1500

catgtgtatg aaaagcacgc taattggact ttaactccat tgaagtccct cgactttgac     1560

acccttgtgg ataacatctc tgtggatcct gtgacagggg acctctgggt gggatgccat     1620

cccaacggaa tgcgaatctt ctactatgac ccaaagaatc ctcccggctc agaggtgctt     1680

cgaatccagg acattttatc cgaagagccc aaagtgacag tggtttatgc agaaaatggc     1740

actgtgttac agggcagcac ggtggccgct gtgtacaaag ggaaactgct gattggcaca     1800

gtgtttcaca aagctcttta ctgtgagctg                                      1830


<210>  144
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[G3C9 PON1]

<400>  144

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
                245                 250                 255     


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
            260                 265                 270         


Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu 
        275                 280                 285             


Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp 
    290                 295                 300                 


Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
305                 310                 315                 320 


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys 
                325                 330                 335     


Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val 
            340                 345                 350         


Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn 
        355                 360                 365             


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu 
    370                 375                 380                 


Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys 
385                 390                 395                 400 


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
                405                 410                 415     


Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His 
            420                 425                 430         


Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser 
        435                 440                 445             


Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser 
    450                 455                 460                 


Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly 
465                 470                 475                 480 


Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu 
                485                 490                 495     


Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr 
            500                 505                 510         


Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val 
        515                 520                 525             


Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met 
    530                 535                 540                 


Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu 
545                 550                 555                 560 


Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr 
                565                 570                 575     


Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val Tyr 
            580                 585                 590         


Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  145
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[M-IIG1 PON1] DNA

<400>  145
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gagcccaaat cttctgacaa aactcacaca tgtccaccgt gcccagcacc tgaactcctg      120

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      180

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      240

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      300

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      360

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc      420

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      480

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      540

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      600

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      660

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      720

tacacgcaga agagcctctc tctctctccg ggtaaagtcg acggagctag cagccccgtg      780

aacgtgagca gccccagcgt gcaggatatc ctcttcgatg gacagaagtc ttctttccaa      840

acacgattta atgttcaccg tgaagtaact ccagtggaac ttcctaactg taatttagtt      900

aaaggggttg acaatggttc tgaagacatt gaaatactgc ccaatggact ggctttcatc      960

agctccggag ttaagtatcc tggaataatg agctttgacc ctgataagtc tggaaagata     1020

cttctaatgg acctgaatga ggaagaccca gtagtgttgg aactgggcat tactggaaat     1080

acattggata tatcttcatt taaccctgct gggattagca cattcacaga tgaagataac     1140

actgtgtacc tactggtggt aaaccgacca gactcctcgt ccaccgtgga ggtgtttaaa     1200

tttcaagaag aagaaaaatc acttttgcat ctgaaaacca tcagacacaa gcttctgcct     1260

agtgtgaatg acattgtcgc tgtgggacct gaacactttt atgccacaaa tgatcactat     1320

tttgctgacc cttacttaaa atcctgggaa atgcatttgg gattagcgtg gtcatttgtt     1380

acttattata gtcccaatga tgttcgagta gtggcagaag gatttgatat ggctaacgga     1440

atcaacatct caccagacgg caagtatgtc tatatagctg agttgctggc tcataagatc     1500

catgtgtatg aaaagcacgc taattggact ttaactccat tgaagtccct cgactttgac     1560

acccttgtgg ataacatctc tgtggatcct gtgacagggg acctctgggt gggatgccat     1620

cccaacggaa tgcgattatt ctactatgac ccaaagaatc ctcccggctc agaggtgctt     1680

cgaatccagg acattttatc cgaagagccc aaagtgacag tggtttatgc agaaaatggc     1740

actgtgttac agggcagcag tgtggccgct gtgtacaaag ggaaactgct gattggcaca     1800

gtgtttcaca aagctcttta ctgtgagctg                                      1830


<210>  146
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[SCChinge-P238S-P331S Fc]-NGS-[M-IIG1 PON1]

<400>  146

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
                245                 250                 255     


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
            260                 265                 270         


Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg Glu 
        275                 280                 285             


Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val Asp 
    290                 295                 300                 


Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
305                 310                 315                 320 


Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp Lys 
                325                 330                 335     


Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val Val 
            340                 345                 350         


Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe Asn 
        355                 360                 365             


Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr Leu 
    370                 375                 380                 


Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe Lys 
385                 390                 395                 400 


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
                405                 410                 415     


Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu His 
            420                 425                 430         


Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys Ser 
        435                 440                 445             


Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr Ser 
    450                 455                 460                 


Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn Gly 
465                 470                 475                 480 


Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu 
                485                 490                 495     


Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr 
            500                 505                 510         


Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser Val 
        515                 520                 525             


Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met 
    530                 535                 540                 


Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val Leu 
545                 550                 555                 560 


Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val Tyr 
                565                 570                 575     


Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val Tyr 
            580                 585                 590         


Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  147
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  147
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccat tcattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840

gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga      900

ggtggttctg gaggaggtgg tagtggaggt ggaggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaagtcgac ggagctagca gccccgtgaa cgtgagcagc     1680

cccagcgtgc aggatatcct cttcaggaac caccagtctt cttaccaaac acgacttaat     1740

gctctccgag aggtacaacc cgtagaactt cctaactgta atttagttaa aggaatcgaa     1800

actggctctg aagacttgga gatactgcct aatggactgg ctttcattag ctctggatta     1860

aagtatcctg gaataaagag cttcaacccc aacagtcctg gaaaaatact tctgatggac     1920

ctgaatgaag aagatccaac agtgttggaa ttggggatca ctggaagtaa atttgatgta     1980

tcttcattta accctcatgg gattagcaca ttcacagatg aagataatgc catgtacctc     2040

ctggtggtga accatccaga tgccaagtcc acagtggagt tgtttaaatt tcaagaagaa     2100

gaaaaatcgc ttttgcatct aaaaaccatc agacataaac ttctgcctaa tttgaatgat     2160

attgttgctg tgggacctga gcacttttat ggcacaaatg atcactattt tcttgacccc     2220

tacttaaaat cctgggagat gtatttgggt ttagcgtggt cgtatgttgt ctactatagt     2280

ccaagtgaag ttcgagtggt ggcagaagga tttgattttg ctaatggaat caacatttca     2340

cccgatggca agtatgtcta tatagctgag ttgctggctc ataagattca tgtgtatgaa     2400

aagcatgcta attggacttt aactccattg aagtcccttg actttaatac cctcgtggat     2460

aacatatctg tggatcctga gacaggagac ctttgggttg gatgccatcc caatggcatg     2520

aaaatcttct tctatgactc agagaatcct cctgcatcag aggtgcttcg aatccagaac     2580

attctaacag aagaacctaa agtgacacag gtttatgcag aaaatggcac agtgttgcaa     2640

ggcagtacag ttgcctctgt gtacaaaggg aaactgctga ttggcacagt gtttcacaaa     2700

gctctttact gtgagctcta a                                               2721


<210>  148
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R-A114F]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  148

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


<210>  149
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74X-G105X-A114X]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa is Phe, Glu, Met, Arg, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  149

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Xaa Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Xaa Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Xaa Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  150
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74K-G105R-A114F]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  150

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Phe Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  151
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R] DNA

<400>  151
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

ctgaagatcg cagccttcaa catccagaca tttggggaga ccaagatgtc caatgccacc      120

ctcgtcagct acattgtgca gatcctgagc cgctatgaca tcgccctggt ccaggaggtc      180

agagacagcc acctgactgc cgtggggaag ctgctggaca acctcaatca ggatgcacca      240

gacacctatc actacgtggt cagtgagcca ctgggacgga agagctataa ggagcgctac      300

ctgttcgtgt acaggcctga ccaggtgtct gcggtggaca gctactacta cgatgatggc      360

tgcgagccct gcaggaacga caccttcaac cgagagccag ccattgtcag gttcttctcc      420

cggttcacag aggtcaggga gtttgccatt gttcccctgc atgcggcccc gggggacgca      480

gtagccgaga tcgacgctct ctatgacgtc tacctggatg tccaagagaa atggggcttg      540

gaggacgtca tgttgatggg cgacttcaat gcgggctgca gctatgtgag accctcccag      600

tggtcatcca tccgcctgtg gacaagcccc accttccagt ggctgatccc cgacagcgct      660

gacaccacag ctacacccac gcactgtgcc tatgacagga tcgtggttgc agggatgctg      720

ctccgaggcg ccgttgttcc cgactcggct cttcccttta acttccaggc tgcctatggc      780

ctgagtgacc aactggccca agccatcagt gaccactatc cagtggaggt gatgctgaaa      840


<210>  152
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]

<400>  152

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys 
        275                 280 


<210>  153
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74X-G105X]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  153

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Xaa Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Xaa Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  154
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [hDNase1 N74K-G105R]-[gs linker]-[SSShinge Fc]


<220>
<221>  MISC_FEATURE
<222>  (261)..(263)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (264)..(283)
<223>  Xaa is Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (284)..(293)
<223>  Xaa is Gly or Ser or is absent

<220>
<221>  MISC_FEATURE
<222>  (294)..(296)
<223>  Xaa is any naturally occurring non-cysteine amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(316)
<223>  Xaa is Leu or Ala

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (333)..(333)
<223>  Xaa is Met or Tyr

<220>
<221>  MISC_FEATURE
<222>  (335)..(335)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  Xaa is Thr or Glu

<220>
<221>  MISC_FEATURE
<222>  (346)..(346)
<223>  Xaa is Asp or Ala

<220>
<221>  MISC_FEATURE
<222>  (378)..(378)
<223>  Xaa is Asn, Ala, Gln, or Gly

<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  Xaa is Pro, Ala, Gly, or Ser

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa is Pro, Ser, or Ala

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  Xaa is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (515)..(515)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (528)..(528)
<223>  Xaa is Lys or is absent

<400>  154

Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile Leu Ser Arg Tyr 
            20                  25                  30          


Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His Leu Thr Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro Asp Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser Tyr Tyr 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr Phe Asn Arg Glu 
            100                 105                 110         


Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val Arg Glu Phe 
        115                 120                 125             


Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys Trp Gly Leu 
145                 150                 155                 160 


Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr Val 
                165                 170                 175     


Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Pro Thr His 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu Arg Gly Ala 
    210                 215                 220                 


Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Met Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
    290                 295                 300                 


His Thr Ser Pro Pro Ser Pro Ala Pro Glu Xaa Xaa Gly Gly Xaa Ser 
305                 310                 315                 320 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Xaa Ile Xaa Arg 
                325                 330                 335     


Xaa Pro Glu Val Thr Cys Val Val Val Xaa Val Ser His Glu Asp Pro 
            340                 345                 350         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        355                 360                 365             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val 
    370                 375                 380                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
385                 390                 395                 400 


Lys Cys Lys Val Ser Asn Lys Ala Leu Xaa Ala Xaa Ile Glu Lys Thr 
                405                 410                 415     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            420                 425                 430         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        435                 440                 445             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    450                 455                 460                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
465                 470                 475                 480 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Xaa His Glu Ala 
            500                 505                 510         


Leu His Xaa His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Xaa 
        515                 520                 525             


<210>  155
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N96K-G127R]-(g4s)4-[SSShinge-P238S-P331S Fc]

<400>  155

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535             


<210>  156
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N96K-G127R]-(g4s)6-[SSShinge-P238S-P331S Fc]

<400>  156

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys 
545             


<210>  157
<211>  2713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  157
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc agccattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc taccggtctc gagcccaaat cttctgacaa aactcacaca      960

tctccaccgt ccccagcacc tgaactcctg ggaggatcgt cagtcttcct cttcccccca     1020

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1080

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1140

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1200

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1260

aaagccctcc cagcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1320

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1380

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1440

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1500

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1560

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc tctctctccg     1620

ggtaaagtcg acggagctag cagccccgtg aacgtgagca gccccagcgt gcaggatatc     1680

ctcttcagga accaccagtc ttcttaccaa acacgactta atgctctccg agaggtacaa     1740

cccgtagaac ttcctaactg taatttagtt aaaggaatcg aaactggctc tgaagacttg     1800

gagatactgc ctaatggact ggctttcatt agctctggat taaagtatcc tggaataaag     1860

agcttcaacc ccaacagtcc tggaaaaata cttctgatgg acctgaatga agaagatcca     1920

acagtgttgg aattggggat cactggaagt aaatttgatg tatcttcatt taaccctcat     1980

gggattagca cattcacaga tgaagataat gccatgtacc tcctggtggt gaaccatcca     2040

gatgccaagt ccacagtgga gttgtttaaa tttcaagaag aagaaaaatc gcttttgcat     2100

ctaaaaacca tcagacataa acttctgcct aatttgaatg atattgttgc tgtgggacct     2160

gagcactttt atggcacaaa tgatcactat tttcttgacc cctacttaaa atcctgggag     2220

atgtatttgg gtttagcgtg gtcgtatgtt gtctactata gtccaagtga agttcgagtg     2280

gtggcagaag gatttgattt tgctaatgga atcaacattt cacccgatgg caagtatgtc     2340

tatatagctg agttgctggc tcataagatt catgtgtatg aaaagcatgc taattggact     2400

ttaactccat tgaagtccct tgactttaat accctcgtgg ataacatatc tgtggatcct     2460

gagacaggag acctttgggt tggatgccat cccaatggca tgaaaatctt cttctatgac     2520

tcagagaatc ctcctgcatc agaggtgctt cgaatccaga acattctaac agaagaacct     2580

aaagtgacac aggtttatgc agaaaatggc acagtgttgc aaggcagtac agttgcctct     2640

gtgtacaaag ggaaactgct gattggcaca gtgtttcaca aagctcttta ctgtgagctc     2700

taataatcta gaa                                                        2713


<210>  158
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)4-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  158

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
    290                 295                 300                 


Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        435                 440                 445             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala Ser Ser 
    530                 535                 540                 


Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe Arg Asn 
545                 550                 555                 560 


His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu Val Gln 
                565                 570                 575     


Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu Thr Gly 
            580                 585                 590         


Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser 
        595                 600                 605             


Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly 
    610                 615                 620                 


Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val Leu Glu 
625                 630                 635                 640 


Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn Pro His 
                645                 650                 655     


Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu Leu Val 
            660                 665                 670         


Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys Phe Gln 
        675                 680                 685             


Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His Lys Leu 
    690                 695                 700                 


Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His Phe Tyr 
705                 710                 715                 720 


Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu 
                725                 730                 735     


Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser 
            740                 745                 750         


Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn 
        755                 760                 765             


Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu Leu Ala His 
    770                 775                 780                 


Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu Thr Pro Leu 
785                 790                 795                 800 


Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser Val Asp Pro 
                805                 810                 815     


Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly Met Lys Ile 
            820                 825                 830         


Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val Leu Arg Ile 
        835                 840                 845             


Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val Tyr Ala Glu 
    850                 855                 860                 


Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val Tyr Lys Gly 
865                 870                 875                 880 


Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
                885                 890                 895     


<210>  159
<211>  2743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K] DNA

<400>  159
aagcttgccg ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gtctgaagat cgcagccttc aacatccaga catttgggga gaccaagatg      120

tccaatgcca ccctcgtcag ctacattgtg cagatcctga gccgctatga catcgccctg      180

gtccaggagg tcagagacag ccacctgact gccgtgggga agctgctgga caacctcaat      240

caggatgcac cagacaccta tcactacgtg gtcagtgagc cactgggacg gaagagctat      300

aaggagcgct acctgttcgt gtacaggcct gaccaggtgt ctgcggtgga cagctactac      360

tacgatgatg gctgcgagcc ctgcaggaac gacaccttca accgagagcc agccattgtc      420

aggttcttct cccggttcac agaggtcagg gagtttgcca ttgttcccct gcatgcggcc      480

ccgggggacg cagtagccga gatcgacgct ctctatgacg tctacctgga tgtccaagag      540

aaatggggct tggaggacgt catgttgatg ggcgacttca atgcgggctg cagctatgtg      600

agaccctccc agtggtcatc catccgcctg tggacaagcc ccaccttcca gtggctgatc      660

cccgacagcg ctgacaccac agctacaccc acgcactgtg cctatgacag gatcgtggtt      720

gcagggatgc tgctccgagg cgccgttgtt cccgactcgg ctcttccctt taacttccag      780

gctgcctatg gcctgagtga ccaactggcc caagccatca gtgaccacta tccagtggag      840

gtgatgctga aagatctctc cggaggaggt ggctcaggtg gtggaggatc tggaggaggt      900

gggagtggtg gaggtggttc tggaggaggt ggtagtggag gtggaggttc taccggtctc      960

gagcccaaat cttctgacaa aactcacaca tctccaccgt ccccagcacc tgaactcctg     1020

ggaggatcgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1080

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1140

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1200

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1260

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc     1320

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1380

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1440

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1500

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1560

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1620

tacacgcaga agagcctctc tctctctccg ggtaaagtcg acggagctag cagccccgtg     1680

aacgtgagca gccccagcgt gcaggatatc ctcttcagga accaccagtc ttcttaccaa     1740

acacgactta atgctctccg agaggtacaa cccgtagaac ttcctaactg taatttagtt     1800

aaaggaatcg aaactggctc tgaagacttg gagatactgc ctaatggact ggctttcatt     1860

agctctggat taaagtatcc tggaataaag agcttcaacc ccaacagtcc tggaaaaata     1920

cttctgatgg acctgaatga agaagatcca acagtgttgg aattggggat cactggaagt     1980

aaatttgatg tatcttcatt taaccctcat gggattagca cattcacaga tgaagataat     2040

gccatgtacc tcctggtggt gaaccatcca gatgccaagt ccacagtgga gttgtttaaa     2100

tttcaagaag aagaaaaatc gcttttgcat ctaaaaacca tcagacataa acttctgcct     2160

aatttgaatg atattgttgc tgtgggacct gagcactttt atggcacaaa tgatcactat     2220

tttcttgacc cctacttaaa atcctgggag atgtatttgg gtttagcgtg gtcgtatgtt     2280

gtctactata gtccaagtga agttcgagtg gtggcagaag gatttgattt tgctaatgga     2340

atcaacattt cacccgatgg caagtatgtc tatatagctg agttgctggc tcataagatt     2400

catgtgtatg aaaagcatgc taattggact ttaactccat tgaagtccct tgactttaat     2460

accctcgtgg ataacatatc tgtggatcct gagacaggag acctttgggt tggatgccat     2520

cccaatggca tgaaaatctt cttctatgac tcagagaatc ctcctgcatc agaggtgctt     2580

cgaatccaga acattctaac agaagaacct aaagtgacac aggtttatgc agaaaatggc     2640

acagtgttgc aaggcagtac agttgcctct gtgtacaaag ggaaactgct gattggcaca     2700

gtgtttcaca aagctcttta ctgtgagctc taataatcta gaa                       2743


<210>  160
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1 N74K-G105R]-(g4s)6-[SSShinge-P238S-P331S 
       Fc]-NGS-[PON1 Q192K]

<400>  160

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr Phe Gly 
            20                  25                  30          


Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val Gln Ile 
        35                  40                  45              


Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp Ser His 
    50                  55                  60                  


Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp Ala Pro 
65                  70                  75                  80  


Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Lys Ser Tyr 
                85                  90                  95      


Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val 
            100                 105                 110         


Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Arg Asn Asp Thr 
        115                 120                 125             


Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu 
    130                 135                 140                 


Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala 
145                 150                 155                 160 


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu 
                165                 170                 175     


Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly 
            180                 185                 190         


Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr 
        195                 200                 205             


Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala 
    210                 215                 220                 


Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu 
225                 230                 235                 240 


Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln 
                245                 250                 255     


Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser Asp His 
            260                 265                 270         


Tyr Pro Val Glu Val Met Leu Lys Asp Leu Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


<210>  161
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80A-R95A-N96A 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K] DNA

<400>  161
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcagca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gagcagctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaagtcgac ggagctagca gccccgtgaa cgtgagcagc     1680

cccagcgtgc aggatatcct cttcaggaac caccagtctt cttaccaaac acgacttaat     1740

gctctccgag aggtacaacc cgtagaactt cctaactgta atttagttaa aggaatcgaa     1800

actggctctg aagacttgga gatactgcct aatggactgg ctttcattag ctctggatta     1860

aagtatcctg gaataaagag cttcaacccc aacagtcctg gaaaaatact tctgatggac     1920

ctgaatgaag aagatccaac agtgttggaa ttggggatca ctggaagtaa atttgatgta     1980

tcttcattta accctcatgg gattagcaca ttcacagatg aagataatgc catgtacctc     2040

ctggtggtga accatccaga tgccaagtcc acagtggagt tgtttaaatt tcaagaagaa     2100

gaaaaatcgc ttttgcatct aaaaaccatc agacataaac ttctgcctaa tttgaatgat     2160

attgttgctg tgggacctga gcacttttat ggcacaaatg atcactattt tcttgacccc     2220

tacttaaaat cctgggagat gtatttgggt ttagcgtggt cgtatgttgt ctactatagt     2280

ccaagtgaag ttcgagtggt ggcagaagga tttgattttg ctaatggaat caacatttca     2340

cccgatggca agtatgtcta tatagctgag ttgctggctc ataagattca tgtgtatgaa     2400

aagcatgcta attggacttt aactccattg aagtcccttg actttaatac cctcgtggat     2460

aacatatctg tggatcctga gacaggagac ctttgggttg gatgccatcc caatggcatg     2520

aaaatcttct tctatgactc agagaatcct cctgcatcag aggtgcttcg aatccagaac     2580

attctaacag aagaacctaa agtgacacag gtttatgcag aaaatggcac agtgttgcaa     2640

ggcagtacag ttgcctctgt gtacaaaggg aaactgctga ttggcacagt gtttcacaaa     2700

gctctttact gtgagctcta a                                               2721


<210>  162
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80A-R95A-N96A 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  162

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ala 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ala Ala 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


<210>  163
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80S-R95S-N96S 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K] DNA

<400>  163
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

atgaggatct gctccttcaa cgtcaggtcc tttggggaaa gcaagcagga agacaagaat      120

gccatggatg tcattgtgaa ggtcatcaaa cgctgtgaca tcatactcgt gatggaaatc      180

aaggacagca acaacaggat ctgccccata ctgatggaga agctgaacag aaattcatca      240

agaggcataa cgtacaacta tgtgattagc tctcggcttg gaagttctac atataaagaa      300

caatatgcct ttctctacaa ggaaaagctg gtgtctgtga agaggagtta tcactaccat      360

gactatcagg atggagacgc agatgtgttt tccagggagc cctttgtggt ctggttccaa      420

tctccccaca ctgctgtcaa agacttcgtg attatccccc tgcacaccac cccagagaca      480

tccgttaagg agatcgatga gttggttgag gtctacacgg acgtgaaaca ccgctggaag      540

gcggagaatt tcattttcat gggtgacttc aatgccggct gcagctacgt ccccaagaag      600

gcctggaaga acatccgctt gaggactgac cccaggtttg tttggctgat cggggaccaa      660

gaggacacca cggtgaagaa gagcaccaac tgtgcatatg acaggattgt gcttagagga      720

caagaaatcg tcagttctgt tgttcccaag tcaaacagtg tttttgactt ccagaaagct      780

tacaagctga ctgaagagga ggccctggat gtcagcgacc actttccagt tgaatttaaa      840

ctacagtctt caagggcctt caccaactca gatctctccg gaggaggtgg ctcaggtggt      900

ggaggatctg gaggaggtgg gagtggtgga ggtggttcta ccggtctcga gcccaaatct      960

tctgacaaaa ctcacacatc tccaccgtcc ccagcacctg aactcctggg aggatcgtca     1020

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1080

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1140

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1200

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1260

aagtgcaagg tctccaacaa agccctccca gcctccatcg agaaaaccat ctccaaagcc     1320

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1380

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1440

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1500

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1560

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1620

agcctctctc tctctccggg taaagtcgac ggagctagca gccccgtgaa cgtgagcagc     1680

cccagcgtgc aggatatcct cttcaggaac caccagtctt cttaccaaac acgacttaat     1740

gctctccgag aggtacaacc cgtagaactt cctaactgta atttagttaa aggaatcgaa     1800

actggctctg aagacttgga gatactgcct aatggactgg ctttcattag ctctggatta     1860

aagtatcctg gaataaagag cttcaacccc aacagtcctg gaaaaatact tctgatggac     1920

ctgaatgaag aagatccaac agtgttggaa ttggggatca ctggaagtaa atttgatgta     1980

tcttcattta accctcatgg gattagcaca ttcacagatg aagataatgc catgtacctc     2040

ctggtggtga accatccaga tgccaagtcc acagtggagt tgtttaaatt tcaagaagaa     2100

gaaaaatcgc ttttgcatct aaaaaccatc agacataaac ttctgcctaa tttgaatgat     2160

attgttgctg tgggacctga gcacttttat ggcacaaatg atcactattt tcttgacccc     2220

tacttaaaat cctgggagat gtatttgggt ttagcgtggt cgtatgttgt ctactatagt     2280

ccaagtgaag ttcgagtggt ggcagaagga tttgattttg ctaatggaat caacatttca     2340

cccgatggca agtatgtcta tatagctgag ttgctggctc ataagattca tgtgtatgaa     2400

aagcatgcta attggacttt aactccattg aagtcccttg actttaatac cctcgtggat     2460

aacatatctg tggatcctga gacaggagac ctttgggttg gatgccatcc caatggcatg     2520

aaaatcttct tctatgactc agagaatcct cctgcatcag aggtgcttcg aatccagaac     2580

attctaacag aagaacctaa agtgacacag gtttatgcag aaaatggcac agtgttgcaa     2640

ggcagtacag ttgcctctgt gtacaaaggg aaactgctga ttggcacagt gtttcacaaa     2700

gctctttact gtgagctcta a                                               2721


<210>  164
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hVK3LP-[hDNase1L3 R80S-R95S-N96S 
       NLS2delta]-(g4s)4-[SSShinge-P238S-P331S Fc]-NGS-[PON1 Q192K]

<400>  164

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Ser 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Ser Ser 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser 
305                 310                 315                 320 


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu 
                325                 330                 335     


Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            340                 345                 350         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        355                 360                 365             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    370                 375                 380                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
385                 390                 395                 400 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                405                 410                 415     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            420                 425                 430         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        435                 440                 445             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    450                 455                 460                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
465                 470                 475                 480 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                485                 490                 495     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            500                 505                 510         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        515                 520                 525             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    530                 535                 540                 


Ser Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser 
545                 550                 555                 560 


Pro Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln 
                565                 570                 575     


Thr Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn 
            580                 585                 590         


Cys Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile 
        595                 600                 605             


Leu Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly 
    610                 615                 620                 


Ile Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp 
625                 630                 635                 640 


Leu Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser 
                645                 650                 655     


Lys Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr 
            660                 665                 670         


Asp Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala 
        675                 680                 685             


Lys Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu 
    690                 695                 700                 


Leu His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp 
705                 710                 715                 720 


Ile Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr 
                725                 730                 735     


Phe Leu Asp Pro Tyr Leu Lys Ser Trp Glu Met Tyr Leu Gly Leu Ala 
            740                 745                 750         


Trp Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala 
        755                 760                 765             


Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys 
    770                 775                 780                 


Tyr Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu 
785                 790                 795                 800 


Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn 
                805                 810                 815     


Thr Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp 
            820                 825                 830         


Val Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu 
        835                 840                 845             


Asn Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu 
    850                 855                 860                 


Glu Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln 
865                 870                 875                 880 


Gly Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr 
                885                 890                 895     


Val Phe His Lys Ala Leu Tyr Cys Glu Leu 
            900                 905     


