                         SEQUENCE LISTING

<110>  EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
       PIERCE, BRIAN GREGORY
       WARFIELD, KELLY LYN
 
<120>  MODIFIED SARS-COV-2 SPIKE POLYPEPTIDES AND NANOPARTICLES THEREOF

<130>  2479.224PC01

<150>  US 63/150,454
<151>  2021-02-17

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  9475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression plasmid

<400>  1
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

caccatgttc gtgtttctgg tgctgctgcc tctggtgagc tcccagtgcg tgaacctgac      960

cacaaggacc cagctgccac ctgcctatac caattccttc acacggggcg tgtactatcc     1020

tgacaaggtg tttagatcta gcgtgctgca cagcacacag gatctgtttc tgccattctt     1080

ttccaacgtg acctggttcc acgccatcca cgtgagcggc accaatggca caaagcggtt     1140

cgacaatcct gtgctgccct tcaacgatgg cgtgtacttc gcctccaccg agaagtctaa     1200

catcatcaga ggctggatct ttggcaccac actggacagc aagacacagt ccctgctgat     1260

cgtgaacaat gccaccaacg tggtcatcaa ggtgtgcgag ttccagtttt gtaatgatcc     1320

cttcctgggc gtgtactatc acaagaacaa taagtcttgg atggagagcg agtttagagt     1380

gtattcctct gccaacaatt gtacatttga gtacgtgagc cagcctttcc tgatggacct     1440

ggagggcaag cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgatgg     1500

ctacttcaag atctactcta agcacacccc tatcaacctg gtgcgcgacc tgccacaggg     1560

cttcagcgcc ctggagcctc tggtggatct gccaatcggc atcaacatca cccggtttca     1620

gacactgctg gccctgcaca gaagctacct gacacccggc gacagctcct ctggatggac     1680

cgcaggagca gcagcctact atgtgggcta tctgcagcct aggaccttcc tgctgaagta     1740

caacgagaat ggcaccatca cagacgccgt ggattgcgcc ctggatcctc tgtctgagac     1800

aaagtgtaca ctgaagagct ttaccgtgga gaagggcatc tatcagacaa gcaatttcag     1860

ggtgcagcca accgagtcca tcgtgcgctt tccaaatatc acaaacctgt gcccctttgg     1920

cgaggtgttc aacgcaacca ggttcgccag cgtgtacgca tggaatagga agcgcatctc     1980

caactgcgtg gccgactatt ctgtgctgta caactccgcc tctttcagca cctttaagtg     2040

ctatggcgtg tcccccacaa agctgaatga cctgtgcttt accaacgtgt acgccgattc     2100

tttcgtgatc aggggcgacg aggtgcgcca gatcgcacct ggacagacag gcaagatcgc     2160

cgactacaat tataagctgc cagacgattt caccggctgc gtgatcgcct ggaactctaa     2220

caatctggat agcaaagtgg gcggcaacta caattatctg taccggctgt ttagaaagtc     2280

caatctgaag cccttcgaga gggacatctc cacagagatc taccaggccg gctctacccc     2340

ttgcaatggc gtggagggct ttaactgtta tttccccctg cagagctacg gcttccagcc     2400

tacaaacggc gtgggctatc agccataccg cgtggtggtg ctgagctttg agctgctgca     2460

cgcaccagca acagtgtgcg gacctaagaa gtccaccaat ctggtgaaga acaagtgcgt     2520

gaacttcaac ttcaacggcc tgaccggaac aggcgtgctg accgagtcca acaagaagtt     2580

cctgccattt cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc     2640

acagaccctg gagatcctgg atatcacacc ctgctccttc ggcggcgtgt ctgtgatcac     2700

acccggcacc aatacaagca accaggtggc cgtgctgtat caggacgtga attgtaccga     2760

ggtgcctgtg gccatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg     2820

ctccaacgtg ttccagacaa gagcaggatg cctgatcgga gcagagcacg tgaacaattc     2880

ttatgagtgc gacatcccaa tcggcgccgg catctgtgcc agctaccaga cccagacaaa     2940

ctccccaagg agagcagcct ctgtggcctc ccagtctatc atcgcctata ccatgagcct     3000

gggcgccgag aattccgtgg cctactctaa caatagcatc gccatcccaa ccaacttcac     3060

aatctccgtg accacagaga tcctgcccgt gagcatgacc aagacatccg tggactgcac     3120

aatgtatatc tgtggcgatt ccaccgagtg ctctaacctg ctgctgcagt acggcagctt     3180

ttgtacccag ctgaataggg ccctgacagg aatcgcagtg gagcaggaca agaacacaca     3240

ggaggtgttc gcccaggtga agcagatcta caagacccca cccatcaagg actttggcgg     3300

cttcaacttc agccagatcc tgccagatcc ctccaagcct tctaagcgga gctttatcga     3360

ggacctgctg ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga     3420

ttgcctgggc gacatcgcag cacgggacct gatctgtgcc cagaagttta atggcctgac     3480

cgtgctgcct ccactgctga cagatgagat gatcgcccag tacacatctg ccctgctggc     3540

cggaaccatc acaagcggat ggaccttcgg cgcaggagcc gccctgcaga tcccatttgc     3600

catgcagatg gcctatcgct tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa     3660

ccagaagctg atcgccaatc agtttaactc cgccatcggc aagatccagg actctctgag     3720

ctccacagcc agcgccctgg gcaagctgca ggatgtggtg aatcagaacg cccaggccct     3780

gaataccctg gtgaagcagc tgtctagcaa cttcggcgcc atctcctctg tgctgaatga     3840

tatcctgagc aggctggacc cacctgaggc agaggtgcag atcgaccggc tgatcacagg     3900

cagactgcag tctctgcaga cctacgtgac acagcagctg atcagggcag cagagatcag     3960

ggccagcgcc aatctggcag caaccaagat gagcgagtgc gtgctgggcc agtccaagag     4020

agtggacttt tgtggcaagg gctatcacct gatgagcttc ccacagtccg ccccacacgg     4080

agtggtgttt ctgcacgtga cctacgtgcc cgcccaggag aagaacttca ccacagcccc     4140

tgccatctgc cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtccaacgg     4200

cacccactgg tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa     4260

taccttcgtg agcggcaact gtgacgtggt catcggcatc gtgaacaata ccgtgtatga     4320

tcccctgcag cctgagctgg actcctttaa ggaggagctg gataagtact tcaagaatca     4380

cacctctccc gacgtggatc tgggcgacat ctctggcatc aatgccagcg tggtgaacat     4440

ccagaaggag atcgatcggc tgaacgaggt ggccaagaat ctgaacgaga gcctgatcga     4500

cctgcaggag ctgggcaagt atgagcaggg ctccggcgat atcatcaagc tgctgaatga     4560

gcaggtgaac aaggagatgc agagctccaa tctgtatatg tccatgtcta gctggtgcta     4620

cacccactct ctggacggag caggcctgtt cctgtttgat cacgccgccg aggagtacga     4680

gcacgccaag aagctgatca tcttcctgaa cgagaacaat gtgcccgtgc agctgacaag     4740

catctccgcc cctgagcaca agtttgaggg cctgacccag atcttccaga aggcctatga     4800

gcacgagcag cacatctctg agagcatcaa caatatcgtg gaccacgcca tcaagtccaa     4860

ggatcacgcc accttcaact ttctgcagtg gtacgtggcc gagcagcacg aggaggaggt     4920

gctgttcaag gatatcctgg acaagatcga gctgatcggc aatgagaacc acggcctgta     4980

tctggccgac cagtacgtga agggcatcgc caagagcagg aagtccggct cttgatgata     5040

agcttaagtt taaaccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt     5100

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     5160

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     5220

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     5280

gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctctag ggggtatccc     5340

cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc     5400

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc     5460

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt     5520

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg     5580

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt     5640

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta     5700

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt     5760

aacgcgaatt aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc     5820

cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg tgtggaaagt     5880

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     5940

tagtcccgcc cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc     6000

cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc tctgcctctg     6060

agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc aaaaagctcc     6120

cgggagcttg tatatccatt ttcggatctg atcaagagac aggatgagga tcgtttcgca     6180

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg     6240

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag     6300

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc     6360

aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc     6420

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg     6480

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc     6540

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca     6600

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag     6660

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc atgcccgacg     6720

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg     6780

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca     6840

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc     6900

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg     6960

acgagttctt ctgagcggga ctctggggtt cgaaatgacc gaccaagcga cgcccaacct     7020

gccatcacga gatttcgatt ccaccgccgc cttctatgaa aggttgggct tcggaatcgt     7080

tttccgggac gccggctgga tgatcctcca gcgcggggat ctcatgctgg agttcttcgc     7140

ccaccccaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa     7200

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa     7260

tgtatcttat catgtctgta taccgtcgac ctctagctag agcttggcgt aatcatggtc     7320

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     7380

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     7440

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     7500

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     7560

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     7620

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     7680

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     7740

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     7800

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     7860

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     7920

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     7980

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     8040

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     8100

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     8160

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     8220

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtgtt ttttttgttt gcaagcagca     8280

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     8340

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     8400

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     8460

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     8520

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     8580

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     8640

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     8700

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     8760

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc     8820

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     8880

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     8940

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     9000

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     9060

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag     9120

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     9180

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     9240

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     9300

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta     9360

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     9420

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtc          9475


<210>  2
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified spike sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Leader sequence

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Ala Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


<210>  3
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified ferritin

<400>  3

Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
1               5                   10                  15      


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                  75                  80  


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150                 155                 160 


Arg Lys Ser Gly Ser 
                165 


<210>  4
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  4

Gly Ser Gly 
1           


<210>  5
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein sequence (GenBank: QHD43416.1)


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Leader sequence

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  6
<211>  1376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified spike:linker:ferritin


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Leader sequence

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Ala Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Gly Ser  Gly Asp Ile Ile Lys  Leu Leu Asn 
    1205                 1210                 1215             


Glu Gln  Val Asn Lys Glu Met  Gln Ser Ser Asn Leu  Tyr Met Ser 
    1220                 1225                 1230             


Met Ser  Ser Trp Cys Tyr Thr  His Ser Leu Asp Gly  Ala Gly Leu 
    1235                 1240                 1245             


Phe Leu  Phe Asp His Ala Ala  Glu Glu Tyr Glu His  Ala Lys Lys 
    1250                 1255                 1260             


Leu Ile  Ile Phe Leu Asn Glu  Asn Asn Val Pro Val  Gln Leu Thr 
    1265                 1270                 1275             


Ser Ile  Ser Ala Pro Glu His  Lys Phe Glu Gly Leu  Thr Gln Ile 
    1280                 1285                 1290             


Phe Gln  Lys Ala Tyr Glu His  Glu Gln His Ile Ser  Glu Ser Ile 
    1295                 1300                 1305             


Asn Asn  Ile Val Asp His Ala  Ile Lys Ser Lys Asp  His Ala Thr 
    1310                 1315                 1320             


Phe Asn  Phe Leu Gln Trp Tyr  Val Ala Glu Gln His  Glu Glu Glu 
    1325                 1330                 1335             


Val Leu  Phe Lys Asp Ile Leu  Asp Lys Ile Glu Leu  Ile Gly Asn 
    1340                 1345                 1350             


Glu Asn  His Gly Leu Tyr Leu  Ala Asp Gln Tyr Val  Lys Gly Ile 
    1355                 1360                 1365             


Ala Lys  Ser Arg Lys Ser Gly  Ser 
    1370                 1375     


<210>  7
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ferritin protein sequence (WP_000949190.1)

<400>  7

Met Leu Ser Lys Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys 
1               5                   10                  15      


Glu Met Asn Ser Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr 
            20                  25                  30          


Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala 
        35                  40                  45              


Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn 
    50                  55                  60                  


Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe 
65                  70                  75                  80  


Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His 
                85                  90                  95      


Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys 
            100                 105                 110         


Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His 
        115                 120                 125             


Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile 
    130                 135                 140                 


Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly 
145                 150                 155                 160 


Ile Ala Lys Ser Arg Lys Ser 
                165         


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Ser Gly Gly 
1           


<210>  9

<400>  9
000

<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Gly Ser Ala Ser 
1               


