                               SEQUENCE LISTING

<110> APPLIED MOLECULAR TRANSPORT
 
<120> SOLID ORAL COMPOSITIONS WITH ZINC

<130> 40566-762.601

<140>
<141>

<150> 63/150,078
<151> 2021-02-16

<160> 35    

<170> PatentIn version 3.5

<210> 1
<211> 634
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 2
<211> 386
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala 
385     


<210> 3
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly 
            260                 265     


<210> 4
<211> 386
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala 
385     


<210> 5
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly 
            260                 265     


<210> 6
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala 
385         


<210> 7
<211> 267
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly 
            260                 265         


<210> 8
<211> 387
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala 
385         


<210> 9
<211> 267
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly 
            260                 265         


<210> 10
<211> 179
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210> 11
<211> 146
<212> PRT
<213> Homo sapiens

<400> 11
Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210> 12
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
1               5                   10                  15      


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
            20                  25                  30          


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
        35                  40                  45              


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
    50                  55                  60                  


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
65                  70                  75                  80  


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
                85                  90                  95      


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
            100                 105                 110         


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
        115                 120                 125             


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
    130                 135                 140                 


Ala Cys Ile 
145         


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 14
<211> 548
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe 
                405                 410                 415     


Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala 
            420                 425                 430         


Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu 
        435                 440                 445             


Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val 
    450                 455                 460                 


Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe 
465                 470                 475                 480 


Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn 
                485                 490                 495     


Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg 
            500                 505                 510         


Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly 
        515                 520                 525             


Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg 
    530                 535                 540                 


Asn Ala Cys Ile 
545             


<210> 15
<211> 428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His 
        275                 280                 285             


Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg 
    290                 295                 300                 


Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp 
305                 310                 315                 320 


Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu 
                325                 330                 335     


Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val 
            340                 345                 350         


Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val 
        355                 360                 365             


Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu 
    370                 375                 380                 


Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr 
385                 390                 395                 400 


Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu 
                405                 410                 415     


Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
            420                 425             


<210> 16
<211> 548
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe 
                405                 410                 415     


Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala 
            420                 425                 430         


Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu 
        435                 440                 445             


Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val 
    450                 455                 460                 


Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe 
465                 470                 475                 480 


Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn 
                485                 490                 495     


Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg 
            500                 505                 510         


Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly 
        515                 520                 525             


Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg 
    530                 535                 540                 


Asn Ala Cys Ile 
545             


<210> 17
<211> 428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His 
        275                 280                 285             


Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg 
    290                 295                 300                 


Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp 
305                 310                 315                 320 


Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu 
                325                 330                 335     


Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val 
            340                 345                 350         


Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val 
        355                 360                 365             


Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu 
    370                 375                 380                 


Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr 
385                 390                 395                 400 


Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu 
                405                 410                 415     


Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
            420                 425             


<210> 18
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
                405                 410                 415     


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
            420                 425                 430         


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
        435                 440                 445             


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
    450                 455                 460                 


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
465                 470                 475                 480 


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
                485                 490                 495     


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
            500                 505                 510         


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
        515                 520                 525             


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
    530                 535                 540                 


Ala Cys Ile 
545         


<210> 19
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
                405                 410                 415     


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
            420                 425                 430         


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
        435                 440                 445             


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
    450                 455                 460                 


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
465                 470                 475                 480 


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
                485                 490                 495     


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
            500                 505                 510         


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
        515                 520                 525             


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
    530                 535                 540                 


Ala Cys Ile 
545         


<210> 20
<211> 427
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His Cys 
        275                 280                 285             


Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
    290                 295                 300                 


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
305                 310                 315                 320 


Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg 
                325                 330                 335     


Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
            340                 345                 350         


Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
        355                 360                 365             


Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly 
    370                 375                 380                 


Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val 
385                 390                 395                 400 


Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp 
                405                 410                 415     


Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
            420                 425         


<210> 21
<211> 427
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His Cys 
        275                 280                 285             


Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
    290                 295                 300                 


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
305                 310                 315                 320 


Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg 
                325                 330                 335     


Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
            340                 345                 350         


Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
        355                 360                 365             


Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly 
    370                 375                 380                 


Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val 
385                 390                 395                 400 


Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp 
                405                 410                 415     


Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
            420                 425         


<210> 22
<211> 634
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 23
<211> 635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys 
385                 390                 395                 400 


Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser 
                405                 410                 415     


Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro 
            420                 425                 430         


Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln 
        435                 440                 445             


Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn 
    450                 455                 460                 


His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg 
465                 470                 475                 480 


Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala 
                485                 490                 495     


Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr 
            500                 505                 510         


Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val 
        515                 520                 525             


Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg 
    530                 535                 540                 


Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile 
545                 550                 555                 560 


Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser 
                565                 570                 575     


Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His 
            580                 585                 590         


Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu 
        595                 600                 605             


Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys 
    610                 615                 620                 


Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 635 


<210> 24
<211> 427
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His Cys 
        275                 280                 285             


Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
    290                 295                 300                 


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
305                 310                 315                 320 


Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg 
                325                 330                 335     


Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
            340                 345                 350         


Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
        355                 360                 365             


Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly 
    370                 375                 380                 


Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val 
385                 390                 395                 400 


Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp 
                405                 410                 415     


Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
            420                 425         


<210> 25
<211> 427
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His Cys 
        275                 280                 285             


Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr 
    290                 295                 300                 


Phe Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val 
305                 310                 315                 320 


Arg Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg 
                325                 330                 335     


Cys Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu 
            340                 345                 350         


Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro 
        355                 360                 365             


Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly 
    370                 375                 380                 


Asp Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val 
385                 390                 395                 400 


Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp 
                405                 410                 415     


Leu Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
            420                 425         


<210> 26
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(30)
<223> This sequence may encompass 1-15 "Gly Ser"
      repeating units

<400> 26
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30  


<210> 27
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(60)
<223> This sequence may encompass 1-15 "Gly Gly Gly Ser"
      repeating units

<400> 27
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60  


<210> 28
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(75)
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Ser"
      repeating units

<400> 28
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210> 29
<211> 90
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(90)
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Gly Ser"
      repeating units

<400> 29
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
                85                  90  


<210> 30
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(45)
<223> This sequence may encompass 1-15 "Gly Gly Ser"
      repeating units

<400> 30
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45  


<210> 31
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 32
<211> 418
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser 
            260                 265                 270         


Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
        275                 280                 285             


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
    290                 295                 300                 


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
305                 310                 315                 320 


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
                325                 330                 335     


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
            340                 345                 350         


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
        355                 360                 365             


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
    370                 375                 380                 


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
385                 390                 395                 400 


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
                405                 410                 415     


Cys Ile 
        


<210> 33
<211> 438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser 
    290                 295                 300                 


Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys 
305                 310                 315                 320 


Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu 
                325                 330                 335     


Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys 
            340                 345                 350         


Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp 
        355                 360                 365             


Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu 
    370                 375                 380                 


Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile 
385                 390                 395                 400 


Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu 
                405                 410                 415     


Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser 
            420                 425                 430         


Leu Arg Asn Ala Cys Ile 
        435             


<210> 34
<211> 418
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
1               5                   10                  15      


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
            20                  25                  30          


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
        35                  40                  45              


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
    50                  55                  60                  


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
65                  70                  75                  80  


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
                85                  90                  95      


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
            100                 105                 110         


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
        115                 120                 125             


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
    130                 135                 140                 


Ala Cys Ile Gly Gly Gly Gly Ser Val Glu Glu Ala Leu Asn Ile Phe 
145                 150                 155                 160 


Asp Glu Cys Arg Ser Pro Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro 
                165                 170                 175     


Ile Gln Ser Lys Leu Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly 
            180                 185                 190         


Val Leu Tyr Tyr Ser Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys 
        195                 200                 205             


Asp Glu Asp Lys Gly Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr 
    210                 215                 220                 


Val Arg Ala Thr Arg His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val 
225                 230                 235                 240 


Ile His Leu Asp Ile Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr 
                245                 250                 255     


Asn Arg Lys Glu Gly Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly 
            260                 265                 270         


Glu Asp Ser Pro Ala Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln 
        275                 280                 285             


Gln Arg Asn Ile Ile Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp 
    290                 295                 300                 


Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser 
305                 310                 315                 320 


Val Thr Arg Pro Glu His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser 
                325                 330                 335     


Tyr Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His 
            340                 345                 350         


Trp His Thr Gly Leu Ala Leu Cys Trp Leu Val Pro Met Asp Ala Ile 
        355                 360                 365             


Tyr Asn Tyr Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe 
    370                 375                 380                 


Gly Gly Ser Tyr Glu Thr Val Ala Gly Thr Pro Lys Val Ile Thr Val 
385                 390                 395                 400 


Lys Gln Gly Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser 
                405                 410                 415     


Lys Gly 
        


<210> 35
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Ala Pro Ile Ser Ser His Cys Arg 
385                 390                 395                 400 


Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe 
                405                 410                 415     


Met Leu Ala Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg 
            420                 425                 430         


Leu Ile Gly Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys 
        435                 440                 445             


Tyr Leu Met Lys Gln Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe 
    450                 455                 460                 


Pro Gln Ser Asp Arg Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe 
465                 470                 475                 480 


Leu Ala Arg Leu Ser Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp 
                485                 490                 495     


Asp Leu His Ile Gln Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys 
            500                 505                 510         


Lys Leu Gly Glu Ser Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu 
        515                 520                 525             


Leu Phe Met Ser Leu Arg Asn Ala Cys Ile 
    530                 535             


