                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Bellenger, Justin Leigh
       Che, Ye
       Garcia, Miguel Angel
       Hu, Lei
       Noe, Mark Carl
       Shi, Shuai
 
<120>  METHODS OF PROTECTING RNA

<130>  PC072708

<150>  63/151165
<151>  2021-02-19

<150>  63/261437
<151>  2021-09-21

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  455
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  1
gccagccccc gauugggggc gacacuccac cauagaucac uccccuguga ggaacuacug       60

ucuucacgca gaaagcgucu agccauggcg uuaguaugag ugucgugcag ccuccaggac      120

ccccccuccc gggagagcca uaguggucug cggaaccggu gaguacaccg gaauugccag      180

gacgaccggg uccuuucuug gaucaacccg cucaaugccu ggagauuugg gcgugccccc      240

gcgagacugc uagccgaagu aguguugggu cgcgaaaggc cuugugguac ugccugauag      300

ggugcuugcg agugccccgg gaggucucgu agaccgugca ccaugagcac gaauccuaaa      360

ccucaaagaa aaaccaaacg uaacaccaac cgccgcccac aggacgucug aggcggccgc      420

cgccucagac guccuguggg uuuauugcau cccgc                                 455


<210>  2
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  2
ggatcctaat acgactcact atagccagcc cccgattggg ggcgacactc caccatagat       60

cactcccctg tgaggaacta ctgtcttcac gcagaaagcg tctagccatg gcgttagtat      120

gagtgtcgtg cagcctccag gaccccccct cccgggagag ccatagtggt ctgcggaacc      180

ggtgagtaca ccggaattgc caggacgacc gggtcctttc ttggatcaac ccgctcaatg      240

cctggagatt tgggcgtgcc cccgcgagac tgctagccga gtagtgttgg gtcgcgaaag      300

gccttgtggt actgcctgat agggtgcttg cgagtgcccc gggaggtctc gtagaccgtg      360

caccatgagc acgaatccta aacctcaaag aaaaaccaaa cgtaacacca accgccgccc      420

acaggacgtc tgaggcggcc gccgcctcag acgtcctgtg ggtttattgc atcccgcctc      480

gagtctaga                                                              489


<210>  3
<211>  574
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  3
ucucucgcua ucucggaauc gaggggucug gccuacgcug cgauugcuuc uucagagcau       60

ccuucuucag ccuugugccc ucuacagugg cagccucaca caaacuauca acauggcuuc      120

cgaauccagg cucuaccaga ucuccggcga gaccaagucu caucugcuca aguuccgcuu      180

gacgacaucu cgggccagca aaccucaggc agugauuuau uugauugaua aaaacacuca      240

cgaaauccgc caagacgaug acaagacugu auacaccucc cucgacgaga uagccgacga      300

ccuccccgac agcaccccuc gauucaucuu ccucagcuau cccuugacga ugcccgaugg      360

acggcuaucc gugccuuaca ccaugaucua cuaccucccc aucaacugca augccgcaac      420

aaggaugcuc uacgccggcg caaaagagcu gauacgcaac acggccgagg ugaacaaggu      480

uaucgauaua gagucugcag aggaucugga agauauucca aagcaguuga gcggauagaa      540

auaauaauaa aagaaauaac auguucgcua ugcc                                  574


<210>  4
<211>  612
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  4
uccaccauga aucacuccuc ucucgcuauc ucggaaucga ggggucuggc cuacgcugcg       60

auugcuucuu cagagcaucc uucuucagcc uugugcccuc uacaguggca gccucacaca      120

aacuaucaac auggcuuccg aauccaggcu cuaccagauc uccggcgaga ccaagucuca      180

ucugcucaag uuccgcuuga cgacaucucg ggccagcaaa ccucaggcag ugauuuauuu      240

gauugauaaa aacacucacg aaauccgcca agacgaugac aagacuguau acaccucccu      300

cgacgagaua gccgacgacc uccccgacag caccccucga uucaucuucc ucagcuaucc      360

cuugacgaug cccgauggac ggcuauccgu gccuuacacc augaucuacu accuccccau      420

caacugcaau gccgcaacaa ggaugcucua cgccggcgca aaagagcuga uacgcaacac      480

ggccgaggug aacaagguua ucgauauaga gucugcagag gaucuggaag auauuccaaa      540

gcaguugagc ggauagaaau aauaauaaaa gaaauaacau guucgcuaug ccgaaaaacc      600

aaacguaaca cc                                                          612


<210>  5
<211>  612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  5
tccaccatga atcactcctc tctcgctatc tcggaatcga ggggtctggc ctacgctgcg       60

attgcttctt cagagcatcc ttcttcagcc ttgtgccctc tacagtggca gcctcacaca      120

aactatcaac atggcttccg aatccaggct ctaccagatc tccggcgaga ccaagtctca      180

tctgctcaag ttccgcttga cgacatctcg ggccagcaaa cctcaggcag tgatttattt      240

gattgataaa aacactcacg aaatccgcca agacgatgac aagactgtat acacctccct      300

cgacgagata gccgacgacc tccccgacag cacccctcga ttcatcttcc tcagctatcc      360

cttgacgatg cccgatggac ggctatccgt gccttacacc atgatctact acctccccat      420

caactgcaat gccgcaacaa ggatgctcta cgccggcgca aaagagctga tacgcaacac      480

ggccgaggtg aacaaggtta tcgatataga gtctgcagag gatctggaag atattccaaa      540

gcagttgagc ggatagaaat aataataaaa gaaataacat gttcgctatg ccgaaaaacc      600

aaacgtaaca cc                                                          612


<210>  6
<211>  1667
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  6
uacgccagac aauagauuca gcucgaauaa ugaagccgau uggucacuga uuaacuuggu       60

guaucuacug gguagcaaag gaccgaucuu caccucgcau gaccguugaa uguggcgcaa      120

uucuaguacu ugaauggccu ggccaagcuu auagaacaau cgagacgaau ugaacaccac      180

uaucaaaauc caaauuaugc gguuuucaau cauacaugug gcuuuauggc uggccauggc      240

ggccgguuca uuuacagcua acgcuuacgg agcuguucga ugcgucaugu aucucacagg      300

gcaacacgug guagucccuu cagaaccuca ucucguggau uccauaaccc auuugauacu      360

ggcuuuuaug cgcucugaug ucuucaaugu ggacaaaacg ccugcugaau ucccgcucuu      420

cgcaucaguu gcugagacgc gcgagaaguu caacgcaaau accaagauca uggucgcaau      480

cggcgguugg ggagacgcag gauuugaaga agcugcgcgu gacgauucau cgagaaagcg      540

gugggcuggc cacgucaagg ccaugguuga ccagacagga gccgauggca uugacauuga      600

cugggaauau ccgggaggga accgugacga uuauaaacuc auuccgaacu cucagcggga      660

augggagauu caggcauucg ugcuccuucu ucaagaauug cguuccgccu ugggacaaac      720

gaaacugcuc ucaauugcgg ugccagcgcu ggaacgagau uugauggccu ucacaaacuc      780

gacuauuccg uccauugugg aucaaguuga cuuuaucagu guaaugacuu acgacaugau      840

gaaccgacgc gacaacguug ucaagcacca cagcggcgug gcugacuccu gggaagcaau      900

gaagcgauau auagaucgcg gcgucccucc gcacaagcug aacuuuggac uugguuacua      960

ugccaaaugg uucaugacug aacaaugcga uguacagcac ccauuaggau gccgcacuca     1020

acugcuagaa gaccccgcca auggagccga ucuuggcaag acugcagcuu uuagcuggca     1080

cgacgagguu cccgcagaaa uggccaauuc cuuuggcaaa gcccaugcuc auggccgcua     1140

cuaugaagau ggaagcuacg gcuauuggga cgaugaagag aagagauggu gguccuacga     1200

cacgccucuc accaucaaag ccaaagugcc ucggcuucuc ggcgagcugc agcugggcgg     1260

gguguuugcc ugggggcugg gcgaggacgc uccgcaguuu cugcaccuga aggcgacugu     1320

ugacggcauu cggguucugc gcggagauga cgaugcugug aaggaugagc uguaacaagc     1380

agcggcgugu guacgucugg aguuuggcga caucauugaa ggcgugggau gcaauucaag     1440

ccauugauac ugcagauaag uugaagcagc aacagccaaa acucugcacg uggcccgaga     1500

cuuccgucuu auagcaggga acagacagga uggugcugac ggaauaugca gagcucgagc     1560

ucaaccggua ggcuagcuug aaaaccccau gagcuagcag uuaaccuugc aguuaagggu     1620

aaccagagcu uaaacacguc ugauuuggug caaugaauac aggcugc                   1667


<210>  7
<211>  1705
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  7
uccaccauga aucacuccua cgccagacaa uagauucagc ucgaauaaug aagccgauug       60

gucacugauu aacuuggugu aucuacuggg uagcaaagga ccgaucuuca ccucgcauga      120

ccguugaaug uggcgcaauu cuaguacuug aauggccugg ccaagcuuau agaacaaucg      180

agacgaauug aacaccacua ucaaaaucca aauuaugcgg uuuucaauca uacauguggc      240

uuuauggcug gccauggcgg ccgguucauu uacagcuaac gcuuacggag cuguucgaug      300

cgucauguau cucacagggc aacacguggu agucccuuca gaaccucauc ucguggauuc      360

cauaacccau uugauacugg cuuuuaugcg cucugauguc uucaaugugg acaaaacgcc      420

ugcugaauuc ccgcucuucg caucaguugc ugagacgcgc gagaaguuca acgcaaauac      480

caagaucaug gucgcaaucg gcgguugggg agacgcagga uuugaagaag cugcgcguga      540

cgauucaucg agaaagcggu gggcuggcca cgucaaggcc augguugacc agacaggagc      600

cgauggcauu gacauugacu gggaauaucc gggagggaac cgugacgauu auaaacucau      660

uccgaacucu cagcgggaau gggagauuca ggcauucgug cuccuucuuc aagaauugcg      720

uuccgccuug ggacaaacga aacugcucuc aauugcggug ccagcgcugg aacgagauuu      780

gauggccuuc acaaacucga cuauuccguc cauuguggau caaguugacu uuaucagugu      840

aaugacuuac gacaugauga accgacgcga caacguuguc aagcaccaca gcggcguggc      900

ugacuccugg gaagcaauga agcgauauau agaucgcggc gucccuccgc acaagcugaa      960

cuuuggacuu gguuacuaug ccaaaugguu caugacugaa caaugcgaug uacagcaccc     1020

auuaggaugc cgcacucaac ugcuagaaga ccccgccaau ggagccgauc uuggcaagac     1080

ugcagcuuuu agcuggcacg acgagguucc cgcagaaaug gccaauuccu uuggcaaagc     1140

ccaugcucau ggccgcuacu augaagaugg aagcuacggc uauugggacg augaagagaa     1200

gagauggugg uccuacgaca cgccucucac caucaaagcc aaagugccuc ggcuucucgg     1260

cgagcugcag cugggcgggg uguuugccug ggggcugggc gaggacgcuc cgcaguuucu     1320

gcaccugaag gcgacuguug acggcauucg gguucugcgc ggagaugacg augcugugaa     1380

ggaugagcug uaacaagcag cggcgugugu acgucuggag uuuggcgaca ucauugaagg     1440

cgugggaugc aauucaagcc auugauacug cagauaaguu gaagcagcaa cagccaaaac     1500

ucugcacgug gcccgagacu uccgucuuau agcagggaac agacaggaug gugcugacgg     1560

aauaugcaga gcucgagcuc aaccgguagg cuagcuugaa aaccccauga gcuagcaguu     1620

aaccuugcag uuaaggguaa ccagagcuua aacacgucug auuuggugca augaauacag     1680

gcugcgaaaa accaaacgua acacc                                           1705


<210>  8
<211>  1705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  8
tccaccatga atcactccta cgccagacaa tagattcagc tcgaataatg aagccgattg       60

gtcactgatt aacttggtgt atctactggg tagcaaagga ccgatcttca cctcgcatga      120

ccgttgaatg tggcgcaatt ctagtacttg aatggcctgg ccaagcttat agaacaatcg      180

agacgaattg aacaccacta tcaaaatcca aattatgcgg ttttcaatca tacatgtggc      240

tttatggctg gccatggcgg ccggttcatt tacagctaac gcttacggag ctgttcgatg      300

cgtcatgtat ctcacagggc aacacgtggt agtcccttca gaacctcatc tcgtggattc      360

cataacccat ttgatactgg cttttatgcg ctctgatgtc ttcaatgtgg acaaaacgcc      420

tgctgaattc ccgctcttcg catcagttgc tgagacgcgc gagaagttca acgcaaatac      480

caagatcatg gtcgcaatcg gcggttgggg agacgcagga tttgaagaag ctgcgcgtga      540

cgattcatcg agaaagcggt gggctggcca cgtcaaggcc atggttgacc agacaggagc      600

cgatggcatt gacattgact gggaatatcc gggagggaac cgtgacgatt ataaactcat      660

tccgaactct cagcgggaat gggagattca ggcattcgtg ctccttcttc aagaattgcg      720

ttccgccttg ggacaaacga aactgctctc aattgcggtg ccagcgctgg aacgagattt      780

gatggccttc acaaactcga ctattccgtc cattgtggat caagttgact ttatcagtgt      840

aatgacttac gacatgatga accgacgcga caacgttgtc aagcaccaca gcggcgtggc      900

tgactcctgg gaagcaatga agcgatatat agatcgcggc gtccctccgc acaagctgaa      960

ctttggactt ggttactatg ccaaatggtt catgactgaa caatgcgatg tacagcaccc     1020

attaggatgc cgcactcaac tgctagaaga ccccgccaat ggagccgatc ttggcaagac     1080

tgcagctttt agctggcacg acgaggttcc cgcagaaatg gccaattcct ttggcaaagc     1140

ccatgctcat ggccgctact atgaagatgg aagctacggc tattgggacg atgaagagaa     1200

gagatggtgg tcctacgaca cgcctctcac catcaaagcc aaagtgcctc ggcttctcgg     1260

cgagctgcag ctgggcgggg tgtttgcctg ggggctgggc gaggacgctc cgcagtttct     1320

gcacctgaag gcgactgttg acggcattcg ggttctgcgc ggagatgacg atgctgtgaa     1380

ggatgagctg taacaagcag cggcgtgtgt acgtctggag tttggcgaca tcattgaagg     1440

cgtgggatgc aattcaagcc attgatactg cagataagtt gaagcagcaa cagccaaaac     1500

tctgcacgtg gcccgagact tccgtcttat agcagggaac agacaggatg gtgctgacgg     1560

aatatgcaga gctcgagctc aaccggtagg ctagcttgaa aaccccatga gctagcagtt     1620

aaccttgcag ttaagggtaa ccagagctta aacacgtctg atttggtgca atgaatacag     1680

gctgcgaaaa accaaacgta acacc                                           1705


<210>  9
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  9
ggaaucucuc ucacgaacug acguaaucuu                                        30


<210>  10
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  10

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  11
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  11
atgaagtgcc tgctgtacct ggccttcctg ttcatcggcg tgaactgcaa gtttaccatc       60

gtgttccctc acaaccagaa aggcaactgg aagaacgtgc ccagcaacta ccactactgc      120

cccagcagca gcgacctgaa ctggcacaat gacctgatcg gcacagccct gcaagtgaag      180

atgcccaaga gccacaaggc catccaggcc gatggatgga tgtgccacgc cagcaaatgg      240

gtcaccacct gtgacttccg ttggtacggc cccaagtaca tcacccacag catccgcagc      300

ttcaccccta gcgtggaaca gtgcaaagag agcatcgagc agaccaagca aggcacctgg      360

ctgaaccctg gattcccacc tcagagctgt ggctacgcca ctgtgacaga tgccgaggcc      420

gtgatcgtgc aagtgacacc tcatcacgtg ctggtggacg agtacacagg cgagtgggtc      480

gacagccagt tcatcaacgg caagtgctcc aactacatct gccccaccgt gcacaacagc      540

accacctggc acagcgacta caaagtgaag ggcctgtgcg acagcaacct gatcagcatg      600

gacatcacct ttttcagcga ggacggcgag ctgagcagcc tgggaaaaga aggcaccggc      660

ttcagaagca actacttcgc ctatgagaca ggcggcaagg cctgcaagat gcagtattgc      720

aagcactggg gcgtcagact gcctagcgga gtttggttcg agatggccga caaggacctg      780

tttgccgccg ctagattccc tgagtgtcct gagggcagca gcatctctgc ccctagccag      840

acatctgtgg acgtgtccct gatccaggac gtggaacgga tcctggacta cagcctgtgc      900

caagagacat ggtccaagat cagagccggc ctgcctatca gccctgtgga cctgtcttat      960

ctggccccta agaaccctgg caccggacct gccttcacca tcatcaatgg caccctgaag     1020

tactttgaga cacggtacat ccgcgtggac attgccgctc ctatcctgag cagaatggtc     1080

ggaatgatca gcggcaccac caccgagagg gaactgtggg atgattgggc cccttacgag     1140

gatgtggaaa tcggccctaa cggcgtgctg agaacaagca gcggctacaa gttcccactg     1200

tacatgatcg gccacggcat gctggacagc gatctgcacc tgtctagcaa ggcccaggtg     1260

ttcgagcacc ctcacattca ggatgccgcc agccagctgc ctgatgacga gagcctgttc     1320

tttggcgata ccggcctgag caagaacccc atcgaactgg tggaaggctg gttcagcagc     1380

tggaagtcct ctatcgccag cttcttcttc atcatcgggc tgattatcgg cctgttcctg     1440

gtgctgagag tgggcatcca cctgtgcatc aagctgaagc acaccaagaa gcggcagatc     1500

tacaccgaca tcgagatgaa ccggctgggc aagtga                               1536


<210>  12
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  12

Met Gly Thr Val Asn Lys Pro Val Val Gly Val Leu Met Gly Phe Gly 
1               5                   10                  15      


Ile Ile Thr Gly Thr Leu Arg Ile Thr Asn Pro Val Arg Ala Ser Val 
            20                  25                  30          


Leu Arg Tyr Asp Asp Phe His Ile Asp Glu Asp Lys Leu Asp Thr Asn 
        35                  40                  45              


Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp 
    50                  55                  60                  


Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro 
65                  70                  75                  80  


Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His 
                85                  90                  95      


Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu 
            100                 105                 110         


Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp 
        115                 120                 125             


Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His 
    130                 135                 140                 


Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly 
145                 150                 155                 160 


Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val 
                165                 170                 175     


Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr 
            180                 185                 190         


Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys 
        195                 200                 205             


Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr 
    210                 215                 220                 


Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr 
225                 230                 235                 240 


Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys 
                245                 250                 255     


Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp 
            260                 265                 270         


Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val 
        275                 280                 285             


Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg 
    290                 295                 300                 


Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys 
305                 310                 315                 320 


Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro 
                325                 330                 335     


Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser 
            340                 345                 350         


Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His 
        355                 360                 365             


Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp 
    370                 375                 380                 


Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro 
385                 390                 395                 400 


Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr 
                405                 410                 415     


Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys 
            420                 425                 430         


Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met 
        435                 440                 445             


Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys 
    450                 455                 460                 


Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val 
465                 470                 475                 480 


Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr 
                485                 490                 495     


Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr 
            500                 505                 510         


Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val 
        515                 520                 525             


Asn Pro Gly Thr Ser Pro Leu Ile Arg Tyr Ala Ala Trp Thr Gly Gly 
    530                 535                 540                 


Leu Ala Ala Val Val Leu Leu Cys Leu Val Ile Phe Leu Ile Cys Thr 
545                 550                 555                 560 


Ala Lys Arg Met Arg Val Lys Ala Tyr Arg Val Asp Lys Ser Pro Tyr 
                565                 570                 575     


Asn Gln Ser Met Tyr Tyr Ala Gly Leu Pro Val Asp Asp Phe Glu Asp 
            580                 585                 590         


Ser Glu Ser Thr Asp Thr Glu Glu Glu Phe Gly Asn Ala Ile Gly Gly 
        595                 600                 605             


Ser His Gly Gly Ser Ser Tyr Thr Val Tyr Ile Asp Lys Thr Arg 
    610                 615                 620             


<210>  13
<211>  1872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  13
atggggacag ttaataaacc tgtggtgggg gtattgatgg ggttcggaat tatcacggga       60

acgttgcgta taacgaatcc ggtcagagca tccgtcttgc gatacgatga ttttcacatc      120

gatgaagaca aactggatac aaactccgta tatgagcctt actaccattc agatcatgcg      180

gagtcttcat gggtaaatcg gggagagtct tcgcgaaaag cgtacgatca taactcacct      240

tatatatggc cacgtaatga ttatgatgga tttttagaga acgcacacga acaccatggg      300

gtgtataatc agggccgtgg tatcgatagc ggggaacggt taatgcaacc cacacaaatg      360

tctgcacagg aggatcttgg ggacgatacg ggcatccacg ttatccctac gttaaacggc      420

gatgacagac ataaaattgt aaatgtggac caacgtcaat acggtgacgt gtttaaagga      480

gatcttaatc caaaacccca aggccaaaga ctcattgagg tgtcagtgga agaaaatcac      540

ccgtttactt tacgcgcacc gattcagcgg atttatggag tccggtacac cgagacttgg      600

agctttttgc cgtcattaac ctgtacggga gacgcagcgc ccgccatcca gcatatatgc      660

ttaaaacata caacatgctt tcaagacgtg gtggtggatg tggattgcgc ggaaaatact      720

aaagaggatc agttggccga aatcagttac cgttttcaag gtaagaagga agcggaccaa      780

ccgtggattg ttgtaaacac gagcacactg tttgatgaac tcgaattaga cccccccgag      840

attgaaccgg gtgtcttgaa agtacttcgg acagaaaaac aatacttggg tgtgtacatt      900

tggaacatgc gcggctccga tggtacgtct acctacgcca cgtttttggt cacctggaaa      960

ggggatgaaa aaacaagaaa ccctacgccc gcagtaactc ctcaaccaag aggggctgag     1020

tttcatatgt ggaattacca ctcgcatgta ttttcagttg gtgatacgtt tagcttggca     1080

atgcatcttc agtataagat acatgaagcg ccatttgatt tgctgttaga gtggttgtat     1140

gtccccatcg atcctacatg tcaaccaatg cggttatatt ctacgtgttt gtatcatccc     1200

aacgcacccc aatgcctctc tcatatgaat tccggttgta catttacctc gccacattta     1260

gcccagcgtg ttgcaagcac agtgtatcaa aattgtgaac atgcagataa ctacaccgca     1320

tattgtctgg gaatatctca tatggagcct agctttggtc taatcttaca cgacgggggc     1380

accacgttaa agtttgtaga tacacccgag agtttgtcgg gattatacgt ttttgtggtg     1440

tattttaacg ggcatgttga agccgtagca tacactgttg tatccacagt agatcatttt     1500

gtaaacgcaa ttgaagagcg tggatttccg ccaacggccg gtcagccacc ggcgactact     1560

aaacccaagg aaattacccc cgtaaacccc ggaacgtcac cacttatacg atatgccgca     1620

tggaccggag ggcttgcagc agtagtactt ttatgtctcg taatattttt aatctgtacg     1680

gctaaacgaa tgagggttaa agcctatagg gtagacaagt ccccgtataa ccaaagcatg     1740

tattacgctg gccttccagt ggacgatttc gaggactcgg aatctacgga tacggaagaa     1800

gagtttggta acgcgattgg agggagtcac gggggttcga gttacacggt gtatatagat     1860

aagacccggt ga                                                         1872


<210>  14
<211>  1872
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  14
auggggacag uuaauaaacc uguggugggg guauugaugg gguucggaau uaucacggga       60

acguugcgua uaacgaaucc ggucagagca uccgucuugc gauacgauga uuuucacauc      120

gaugaagaca aacuggauac aaacuccgua uaugagccuu acuaccauuc agaucaugcg      180

gagucuucau ggguaaaucg gggagagucu ucgcgaaaag cguacgauca uaacucaccu      240

uauauauggc cacguaauga uuaugaugga uuuuuagaga acgcacacga acaccauggg      300

guguauaauc agggccgugg uaucgauagc ggggaacggu uaaugcaacc cacacaaaug      360

ucugcacagg aggaucuugg ggacgauacg ggcauccacg uuaucccuac guuaaacggc      420

gaugacagac auaaaauugu aaauguggac caacgucaau acggugacgu guuuaaagga      480

gaucuuaauc caaaacccca aggccaaaga cucauugagg ugucagugga agaaaaucac      540

ccguuuacuu uacgcgcacc gauucagcgg auuuauggag uccgguacac cgagacuugg      600

agcuuuuugc cgucauuaac cuguacggga gacgcagcgc ccgccaucca gcauauaugc      660

uuaaaacaua caacaugcuu ucaagacgug gugguggaug uggauugcgc ggaaaauacu      720

aaagaggauc aguuggccga aaucaguuac cguuuucaag guaagaagga agcggaccaa      780

ccguggauug uuguaaacac gagcacacug uuugaugaac ucgaauuaga cccccccgag      840

auugaaccgg gugucuugaa aguacuucgg acagaaaaac aauacuuggg uguguacauu      900

uggaacaugc gcggcuccga ugguacgucu accuacgcca cguuuuuggu caccuggaaa      960

ggggaugaaa aaacaagaaa cccuacgccc gcaguaacuc cucaaccaag aggggcugag     1020

uuucauaugu ggaauuacca cucgcaugua uuuucaguug gugauacguu uagcuuggca     1080

augcaucuuc aguauaagau acaugaagcg ccauuugauu ugcuguuaga gugguuguau     1140

guccccaucg auccuacaug ucaaccaaug cgguuauauu cuacguguuu guaucauccc     1200

aacgcacccc aaugccucuc ucauaugaau uccgguugua cauuuaccuc gccacauuua     1260

gcccagcgug uugcaagcac aguguaucaa aauugugaac augcagauaa cuacaccgca     1320

uauugucugg gaauaucuca uauggagccu agcuuugguc uaaucuuaca cgacgggggc     1380

accacguuaa aguuuguaga uacacccgag aguuugucgg gauuauacgu uuuuguggug     1440

uauuuuaacg ggcauguuga agccguagca uacacuguug uauccacagu agaucauuuu     1500

guaaacgcaa uugaagagcg uggauuuccg ccaacggccg gucagccacc ggcgacuacu     1560

aaacccaagg aaauuacccc cguaaacccc ggaacgucac cacuuauacg auaugccgca     1620

uggaccggag ggcuugcagc aguaguacuu uuaugucucg uaauauuuuu aaucuguacg     1680

gcuaaacgaa ugaggguuaa agccuauagg guagacaagu ccccguauaa ccaaagcaug     1740

uauuacgcug gccuuccagu ggacgauuuc gaggacucgg aaucuacgga uacggaagaa     1800

gaguuuggua acgcgauugg agggagucac ggggguucga guuacacggu guauauagau     1860

aagacccggu ga                                                         1872


<210>  15
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  15

Met Glu Ser Arg Ile Trp Cys Leu Val Val Cys Val Asn Leu Cys Ile 
1               5                   10                  15      


Val Cys Leu Gly Ala Ala Val Ser Ser Ser Ser Thr Arg Gly Thr Ser 
            20                  25                  30          


Ala Thr His Ser His His Ser Ser His Thr Thr Ser Ala Ala His Ser 
        35                  40                  45              


Arg Ser Gly Ser Val Ser Gln Arg Val Thr Ser Ser Gln Thr Val Ser 
    50                  55                  60                  


His Gly Val Asn Glu Thr Ile Tyr Asn Thr Thr Leu Lys Tyr Gly Asp 
65                  70                  75                  80  


Val Val Gly Val Asn Thr Thr Lys Tyr Pro Tyr Arg Val Cys Ser Met 
                85                  90                  95      


Ala Gln Gly Thr Asp Leu Ile Arg Phe Glu Arg Asn Ile Val Cys Thr 
            100                 105                 110         


Ser Met Lys Pro Ile Asn Glu Asp Leu Asp Glu Gly Ile Met Val Val 
        115                 120                 125             


Tyr Lys Arg Asn Ile Val Ala His Thr Phe Lys Val Arg Val Tyr Gln 
    130                 135                 140                 


Lys Val Leu Thr Phe Arg Arg Ser Tyr Ala Tyr Ile His Thr Thr Tyr 
145                 150                 155                 160 


Leu Leu Gly Ser Asn Thr Glu Tyr Val Ala Pro Pro Met Trp Glu Ile 
                165                 170                 175     


His His Ile Asn Ser His Ser Gln Cys Tyr Ser Ser Tyr Ser Arg Val 
            180                 185                 190         


Ile Ala Gly Thr Val Phe Val Ala Tyr His Arg Asp Ser Tyr Glu Asn 
        195                 200                 205             


Lys Thr Met Gln Leu Met Pro Asp Asp Tyr Ser Asn Thr His Ser Thr 
    210                 215                 220                 


Arg Tyr Val Thr Val Lys Asp Gln Trp His Ser Arg Gly Ser Thr Trp 
225                 230                 235                 240 


Leu Tyr Arg Glu Thr Cys Asn Leu Asn Cys Met Val Thr Ile Thr Thr 
                245                 250                 255     


Ala Arg Ser Lys Tyr Pro Tyr His Phe Phe Ala Thr Ser Thr Gly Asp 
            260                 265                 270         


Val Val Asp Ile Ser Pro Phe Tyr Asn Gly Thr Asn Arg Asn Ala Ser 
        275                 280                 285             


Tyr Phe Gly Glu Asn Ala Asp Lys Phe Phe Ile Phe Pro Asn Tyr Thr 
    290                 295                 300                 


Ile Val Ser Asp Phe Gly Arg Pro Asn Ser Ala Leu Glu Thr His Arg 
305                 310                 315                 320 


Leu Val Ala Phe Leu Glu Arg Ala Asp Ser Val Ile Ser Trp Asp Ile 
                325                 330                 335     


Gln Asp Glu Lys Asn Val Thr Cys Gln Leu Thr Phe Trp Glu Ala Ser 
            340                 345                 350         


Glu Arg Thr Ile Arg Ser Glu Ala Glu Asp Ser Tyr His Phe Ser Ser 
        355                 360                 365             


Ala Lys Met Thr Ala Thr Phe Leu Ser Lys Lys Gln Glu Val Asn Met 
    370                 375                 380                 


Ser Asp Ser Ala Leu Asp Cys Val Arg Asp Glu Ala Ile Asn Lys Leu 
385                 390                 395                 400 


Gln Gln Ile Phe Asn Thr Ser Tyr Asn Gln Thr Tyr Glu Lys Tyr Gly 
                405                 410                 415     


Asn Val Ser Val Phe Glu Thr Thr Gly Gly Leu Val Val Phe Trp Gln 
            420                 425                 430         


Gly Ile Lys Gln Lys Ser Leu Val Glu Leu Glu Arg Leu Ala Asn Arg 
        435                 440                 445             


Ser Ser Leu Asn Leu Thr His Asn Arg Thr Lys Arg Ser Thr Asp Gly 
    450                 455                 460                 


Asn Asn Ala Thr His Leu Ser Asn Met Glu Ser Val His Asn Leu Val 
465                 470                 475                 480 


Tyr Ala Gln Leu Gln Phe Thr Tyr Asp Thr Leu Arg Gly Tyr Ile Asn 
                485                 490                 495     


Arg Ala Leu Ala Gln Ile Ala Glu Ala Trp Cys Val Asp Gln Arg Arg 
            500                 505                 510         


Thr Leu Glu Val Phe Lys Glu Leu Ser Lys Ile Asn Pro Ser Ala Ile 
        515                 520                 525             


Leu Ser Ala Ile Tyr Asn Lys Pro Ile Ala Ala Arg Phe Met Gly Asp 
    530                 535                 540                 


Val Leu Gly Leu Ala Ser Cys Val Thr Ile Asn Gln Thr Ser Val Lys 
545                 550                 555                 560 


Val Leu Arg Asp Met Asn Val Lys Glu Ser Pro Gly Arg Cys Tyr Ser 
                565                 570                 575     


Arg Pro Val Val Ile Phe Asn Phe Ala Asn Ser Ser Tyr Val Gln Tyr 
            580                 585                 590         


Gly Gln Leu Gly Glu Asp Asn Glu Ile Leu Leu Gly Asn His Arg Thr 
        595                 600                 605             


Glu Glu Cys Gln Leu Pro Ser Leu Lys Ile Phe Ile Ala Gly Asn Ser 
    610                 615                 620                 


Ala Tyr Glu Tyr Val Asp Tyr Leu Phe Lys Arg Met Ile Asp Leu Ser 
625                 630                 635                 640 


Ser Ile Ser Thr Val Asp Ser Met Ile Ala Leu Asp Ile Asp Pro Leu 
                645                 650                 655     


Glu Asn Thr Asp Phe Arg Val Leu Glu Leu Tyr Ser Gln Lys Glu Leu 
            660                 665                 670         


Arg Ser Ser Asn Val Phe Asp Leu Glu Glu Ile Met Arg Glu Phe Asn 
        675                 680                 685             


Ser Tyr Lys Gln Arg Val Lys Tyr Val Glu Asp Lys Val Val Asp Pro 
    690                 695                 700                 


Leu Pro Pro Tyr Leu Lys Gly Leu Asp Asp Leu Met Ser Gly Leu Gly 
705                 710                 715                 720 


Ala Ala Gly Lys Ala Val Gly Val Ala Ile Gly Ala Val Gly Gly Ala 
                725                 730                 735     


Val Ala Ser Val Val Glu Gly Val Ala Thr Phe Leu Lys Asn Pro Phe 
            740                 745                 750         


Gly Ala Phe Thr Ile Ile Leu Val Ala Ile Ala Val Val Ile Ile Ile 
        755                 760                 765             


Tyr Leu Ile Tyr Thr Arg Gln Arg Arg Leu Cys Met Gln Pro Leu Gln 
    770                 775                 780                 


Asn Leu Phe Pro Tyr Leu Val Ser Ala Asp Gly Thr Thr Val Thr Ser 
785                 790                 795                 800 


Gly Asn Thr Lys Asp Thr Ser Leu Gln Ala Pro Pro Ser Tyr Glu Glu 
                805                 810                 815     


Ser Val Tyr Asn Ser Gly Arg Lys Gly Pro Gly Pro Pro Ser Ser Asp 
            820                 825                 830         


Ala Ser Thr Ala Ala Pro Pro Tyr Thr Asn Glu Gln Ala Tyr Gln Met 
        835                 840                 845             


Leu Leu Ala Leu Val Arg Leu Asp Ala Glu Gln Arg Ala Gln Gln Asn 
    850                 855                 860                 


Gly Thr Asp Ser Leu Asp Gly Gln Thr Gly Thr Gln Asp Lys Gly Gln 
865                 870                 875                 880 


Lys Pro Asn Leu Leu Asp Arg Leu Arg His Arg Lys Asn Gly Tyr Arg 
                885                 890                 895     


His Leu Lys Asp Ser Asp Glu Glu Glu Asn Val 
            900                 905         


<210>  16
<211>  2724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  16
atggaatcca ggatctggtg cctggtagtc tgcgttaact tgtgtatcgt ctgtctgggt       60

gctgcggttt cctcatcttc tactcgtgga acttctgcta ctcacagtca ccattcctct      120

catacgacgt ctgctgctca ttctcgatcc ggttcagtct ctcaacgcgt aacttcttcc      180

caaacggtca gccatggtgt taacgagacc atctacaaca ctaccctcaa gtacggagat      240

gtggtggggg tcaacaccac caagtacccc tatcgcgtgt gttctatggc acagggtacg      300

gatcttattc gctttgaacg taatatcgtc tgcacctcga tgaagcccat caatgaagac      360

ctggacgagg gcatcatggt ggtctacaaa cgcaacatcg tcgcgcacac ctttaaggta      420

cgagtctacc agaaggtttt gacgtttcgt cgtagctacg cttacgtcca caccacttat      480

ctgctgggca gcaacacgga atacgtggcg cctcctatgt gggagattca tcatatcaac      540

agtcacagtc agtgctacag ttcctacagc cgcgttatag caggcacggt tttcgtggct      600

tatcataggg acagctatga aaacaaaacc atgcaattaa tgcccgacga ttattccaac      660

acccacagta cccgttacgt gacggtcaag gatcaatggc acagccgcgg cagcacctgg      720

ctctatcgtg agacctgtaa tctgaattgt atggtgacca tcactactgc gcgctccaag      780

tatccctatc attttttcgc aacttccacg ggtgatgtgg ttgacatttc tcctttctac      840

aacggaacta atcgcaatgc cagctatttt ggagaaaacg ccgacaagtt tttcattttt      900

ccgaactaca ctatcgtctc cgactttgga agaccgaatt ctgcgttaga gacccacagg      960

ttggtggctt ttcttgaacg tgcggactca gtgatctcct gggatataca ggacgagaag     1020

aatgttactt gtcaactcac tttctgggaa gcctcggaac gcaccattcg ttccgaagcc     1080

gaggactcgt atcacttttc ttctgccaaa atgaccgcca ctttcttatc taagaagcaa     1140

gaggtgaaca tgtccgactc tgcgctggac tgtgtacgtg atgaggccat aaataagtta     1200

cagcagattt tcaatacttc atacaatcaa acatatgaaa aatatggaaa cgtgtccgtc     1260

tttgaaacca ctggtggttt ggtggtgttc tggcaaggta tcaagcaaaa atctctggtg     1320

gaactcgaac gtttggccaa ccgctccagt ctgaatctta ctcataatag aaccaaaaga     1380

agtacagatg gcaacaatgc aactcattta tccaacatgg agtcggtgca caatctggtc     1440

tacgcccagc tgcagttcac ctatgacacg ttgcgcggtt acatcaaccg ggcgctggcg     1500

caaatcgcag aagcctggtg tgtggatcaa cggcgcaccc tagaggtctt caaggaactt     1560

agcaagatca acccgtcagc tattctctcg gccatctaca acaaaccgat tgccgcgcgt     1620

ttcatgggcg atgtcctggg tctggccagc tgcgtgacca ttaaccaaac cagcgtcaag     1680

gtgctgcgtg atatgaatgt gaaggaatcg ccaggacgct gctactcacg accagtggtc     1740

atctttaatt tcgccaacag ctcgtacgtg cagtacggtc aactgggcga ggataacgaa     1800

atcctgttgg gcaaccaccg cactgaggaa tgtcagcttc ccagcctcaa gatcttcatc     1860

gccggcaact cggcctacga gtacgtggac tacctcttca aacgcatgat tgacctcagc     1920

agcatctcca ccgtcgacag catgatcgcc ctagacatcg acccgctgga aaacaccgac     1980

ttcagggtac tggaacttta ctcgcagaaa gaattgcgtt ccagcaacgt ttttgatctc     2040

gaggagatca tgcgcgagtt caattcgtat aagcagcggg taaagtacgt ggaggacaag     2100

gtagtcgacc cgctgccgcc ctacctcaag ggtctggacg acctcatgag cggcctgggc     2160

gccgcgggaa aggccgttgg cgtagccatt ggggccgtgg gtggcgcggt ggcctccgtg     2220

gtcgaaggcg ttgccacctt cctcaaaaac cccttcggag ccttcaccat catcctcgtg     2280

gccatagccg tcgtcattat catttatttg atctatactc gacagcggcg tctctgcatg     2340

cagccgctgc agaacctctt tccctatctg gtgtccgccg acgggaccac cgtgacgtcg     2400

ggcaacacca aagacacgtc gttacaggct ccgccttcct acgaggaaag tgtctataat     2460

tctggtcgca aaggaccggg accaccgtcg tctgatgcat ccacggcggc tccgccttac     2520

accaacgagc aggcttacca gatgcttctg gccctggtcc gtctggacgc agagcagcga     2580

gcgcagcaga acggtacaga ttctttggac ggacagactg gcacgcagga caagggacag     2640

aagcccaacc tgctagaccg actgcgacac cgcaaaaacg gctaccgaca cttgaaagac     2700

tccgacgaag aagagaacgt ctga                                            2724


<210>  17
<211>  2724
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  17
auggaaucca ggaucuggug ccugguaguc ugcguuaacu uguguaucgu cugucugggu       60

gcugcgguuu ccucaucuuc uacucgugga acuucugcua cucacaguca ccauuccucu      120

cauacgacgu cugcugcuca uucucgaucc gguucagucu cucaacgcgu aacuucuucc      180

caaacgguca gccauggugu uaacgagacc aucuacaaca cuacccucaa guacggagau      240

gugguggggg ucaacaccac caaguacccc uaucgcgugu guucuauggc acaggguacg      300

gaucuuauuc gcuuugaacg uaauaucguc ugcaccucga ugaagcccau caaugaagac      360

cuggacgagg gcaucauggu ggucuacaaa cgcaacaucg ucgcgcacac cuuuaaggua      420

cgagucuacc agaagguuuu gacguuucgu cguagcuacg cuuacgucca caccacuuau      480

cugcugggca gcaacacgga auacguggcg ccuccuaugu gggagauuca ucauaucaac      540

agucacaguc agugcuacag uuccuacagc cgcguuauag caggcacggu uuucguggcu      600

uaucauaggg acagcuauga aaacaaaacc augcaauuaa ugcccgacga uuauuccaac      660

acccacagua cccguuacgu gacggucaag gaucaauggc acagccgcgg cagcaccugg      720

cucuaucgug agaccuguaa ucugaauugu auggugacca ucacuacugc gcgcuccaag      780

uaucccuauc auuuuuucgc aacuuccacg ggugaugugg uugacauuuc uccuuucuac      840

aacggaacua aucgcaaugc cagcuauuuu ggagaaaacg ccgacaaguu uuucauuuuu      900

ccgaacuaca cuaucgucuc cgacuuugga agaccgaauu cugcguuaga gacccacagg      960

uugguggcuu uucuugaacg ugcggacuca gugaucuccu gggauauaca ggacgagaag     1020

aauguuacuu gucaacucac uuucugggaa gccucggaac gcaccauucg uuccgaagcc     1080

gaggacucgu aucacuuuuc uucugccaaa augaccgcca cuuucuuauc uaagaagcaa     1140

gaggugaaca uguccgacuc ugcgcuggac uguguacgug augaggccau aaauaaguua     1200

cagcagauuu ucaauacuuc auacaaucaa acauaugaaa aauauggaaa cguguccguc     1260

uuugaaacca cuggugguuu ggugguguuc uggcaaggua ucaagcaaaa aucucuggug     1320

gaacucgaac guuuggccaa ccgcuccagu cugaaucuua cucauaauag aaccaaaaga     1380

aguacagaug gcaacaaugc aacucauuua uccaacaugg agucggugca caaucugguc     1440

uacgcccagc ugcaguucac cuaugacacg uugcgcgguu acaucaaccg ggcgcuggcg     1500

caaaucgcag aagccuggug uguggaucaa cggcgcaccc uagaggucuu caaggaacuu     1560

agcaagauca acccgucagc uauucucucg gccaucuaca acaaaccgau ugccgcgcgu     1620

uucaugggcg auguccuggg ucuggccagc ugcgugacca uuaaccaaac cagcgucaag     1680

gugcugcgug auaugaaugu gaaggaaucg ccaggacgcu gcuacucacg accagugguc     1740

aucuuuaauu ucgccaacag cucguacgug caguacgguc aacugggcga ggauaacgaa     1800

auccuguugg gcaaccaccg cacugaggaa ugucagcuuc ccagccucaa gaucuucauc     1860

gccggcaacu cggccuacga guacguggac uaccucuuca aacgcaugau ugaccucagc     1920

agcaucucca ccgucgacag caugaucgcc cuagacaucg acccgcugga aaacaccgac     1980

uucaggguac uggaacuuua cucgcagaaa gaauugcguu ccagcaacgu uuuugaucuc     2040

gaggagauca ugcgcgaguu caauucguau aagcagcggg uaaaguacgu ggaggacaag     2100

guagucgacc cgcugccgcc cuaccucaag ggucuggacg accucaugag cggccugggc     2160

gccgcgggaa aggccguugg cguagccauu ggggccgugg guggcgcggu ggccuccgug     2220

gucgaaggcg uugccaccuu ccucaaaaac cccuucggag ccuucaccau cauccucgug     2280

gccauagccg ucgucauuau cauuuauuug aucuauacuc gacagcggcg ucucugcaug     2340

cagccgcugc agaaccucuu ucccuaucug guguccgccg acgggaccac cgugacgucg     2400

ggcaacacca aagacacguc guuacaggcu ccgccuuccu acgaggaaag ugucuauaau     2460

ucuggucgca aaggaccggg accaccgucg ucugaugcau ccacggcggc uccgccuuac     2520

accaacgagc aggcuuacca gaugcuucug gcccuggucc gucuggacgc agagcagcga     2580

gcgcagcaga acgguacaga uucuuuggac ggacagacug gcacgcagga caagggacag     2640

aagcccaacc ugcuagaccg acugcgacac cgcaaaaacg gcuaccgaca cuugaaagac     2700

uccgacgaag aagagaacgu cuga                                            2724


<210>  18
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  18

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Pro Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Ile Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Met Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  19
<211>  1724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  19
atggagttgc taatcctcaa agcaaatgca attaccacaa tcctcactgc agtcacattt       60

tgttttgctt ctggtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt      120

agcaaaggct atcttagtgc tctgagaact ggttggtata ccagtgttat aactatagaa      180

ttaagtaata tcaaggaaaa taagtgtaat ggaacagatg ctaaggtaaa attgataaaa      240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca      300

ccaccaacaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac      360

aatgccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt      420

ttgttaggtg ttggatctgc aatcgccagt ggcgttgctg tatctaaggt cctgcaccta      480

gaaggggaag tgaacaagat caaaagtgct ctactatcca caaacaaggc tgtagtcagc      540

ttatcaaatg gagttagtgt cttaaccagc aaagtgttag acctcaaaaa ctatatagat      600

aaacaattgt tacctattgt gaacaagcaa agctgcagca tatcaaatat agaaactgtg      660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat      720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta      780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata      840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta      900

gtacaattac cactatatgg tgttatagat acaccctgtt ggaaactaca cacatcccct      960

ctatgtacaa ccaacacaaa agaagggtcc aacatctgtt taacaagaac tgacagagga     1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaac atgtaaagtt     1080

caatcaaatc gagtattttg tgacacaatg aacagtttaa cattaccaag tgaaataaat     1140

ctctgcaatg ttgacatatt caaccccaaa tatgattgta aaattatgac ttcaaaaaca     1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact     1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgcgat     1320

tatgtatcaa ataaagggat ggacactgtg tctgtaggta acacattata ttatgtaaat     1380

agcaagaagg taaaagtctc tatgtaaaag gtgaaccaat aataaatttc tatgacccat     1440

tagtattccc ctctgatgaa tttgatgcat caatatctca agtcaacgag aagattaacc     1500

agagcctagc atttattcgt aaatccgatg aattattaca taatgtaaat gctggtaaat     1560

ccaccacaaa tatcatgata actactataa ttatagtgat tatagtaata ttgttatcat     1620

taattgctgt tggactgctc ttatactgta aggccagaag cacaccagtc acactaagca     1680

aagatcaact gagtggtata aataatattg catttagtaa ctaa                      1724


<210>  20
<211>  1724
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  20
auggaguugc uaauccucaa agcaaaugca auuaccacaa uccucacugc agucacauuu       60

uguuuugcuu cuggucaaaa caucacugaa gaauuuuauc aaucaacaug cagugcaguu      120

agcaaaggcu aucuuagugc ucugagaacu gguugguaua ccaguguuau aacuauagaa      180

uuaaguaaua ucaaggaaaa uaaguguaau ggaacagaug cuaagguaaa auugauaaaa      240

caagaauuag auaaauauaa aaaugcugua acagaauugc aguugcucau gcaaagcaca      300

ccaccaacaa acaaucgagc cagaagagaa cuaccaaggu uuaugaauua uacacucaac      360

aaugccaaaa aaaccaaugu aacauuaagc aagaaaagga aaagaagauu ucuugguuuu      420

uuguuaggug uuggaucugc aaucgccagu ggcguugcug uaucuaaggu ccugcaccua      480

gaaggggaag ugaacaagau caaaagugcu cuacuaucca caaacaaggc uguagucagc      540

uuaucaaaug gaguuagugu cuuaaccagc aaaguguuag accucaaaaa cuauauagau      600

aaacaauugu uaccuauugu gaacaagcaa agcugcagca uaucaaauau agaaacugug      660

auagaguucc aacaaaagaa caacagacua cuagagauua ccagggaauu uaguguuaau      720

gcagguguaa cuacaccugu aagcacuuac auguuaacua auagugaauu auugucauua      780

aucaaugaua ugccuauaac aaaugaucag aaaaaguuaa uguccaacaa uguucaaaua      840

guuagacagc aaaguuacuc uaucaugucc auaauaaaag aggaagucuu agcauaugua      900

guacaauuac cacuauaugg uguuauagau acacccuguu ggaaacuaca cacauccccu      960

cuauguacaa ccaacacaaa agaagggucc aacaucuguu uaacaagaac ugacagagga     1020

ugguacugug acaaugcagg aucaguaucu uucuucccac aagcugaaac auguaaaguu     1080

caaucaaauc gaguauuuug ugacacaaug aacaguuuaa cauuaccaag ugaaauaaau     1140

cucugcaaug uugacauauu caaccccaaa uaugauugua aaauuaugac uucaaaaaca     1200

gauguaagca gcuccguuau cacaucucua ggagccauug ugucaugcua uggcaaaacu     1260

aaauguacag cauccaauaa aaaucgugga aucauaaaga cauuuucuaa cgggugcgau     1320

uauguaucaa auaaagggau ggacacugug ucuguaggua acacauuaua uuauguaaau     1380

agcaagaagg uaaaagucuc uauguaaaag gugaaccaau aauaaauuuc uaugacccau     1440

uaguauuccc cucugaugaa uuugaugcau caauaucuca agucaacgag aagauuaacc     1500

agagccuagc auuuauucgu aaauccgaug aauuauuaca uaauguaaau gcugguaaau     1560

ccaccacaaa uaucaugaua acuacuauaa uuauagugau uauaguaaua uuguuaucau     1620

uaauugcugu uggacugcuc uuauacugua aggccagaag cacaccaguc acacuaagca     1680

aagaucaacu gagugguaua aauaauauug cauuuaguaa cuaa                      1724


<210>  21
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  21

Met Glu Leu Leu Ile His Arg Ser Ser Ala Ile Phe Leu Thr Leu Ala 
1               5                   10                  15      


Val Asn Ala Leu Tyr Leu Thr Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Phe Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Thr Lys Cys Asn Gly Thr Asp Thr Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Asn Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Ala Pro 
            100                 105                 110         


Gln Tyr Met Asn Tyr Thr Ile Asn Thr Thr Lys Asn Leu Asn Val Ser 
        115                 120                 125             


Ile Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asn Asn Arg Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Gln Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Met Asn Ser Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Ile Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Ile Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Asp Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Ser Leu Cys Asn Thr 
    370                 375                 380                 


Asp Ile Phe Asn Ser Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Ile Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly 
    450                 455                 460                 


Lys Asn Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Thr Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Val Leu Leu Ser Leu Ile Ala Ile 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Lys Asn Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Lys 
                565                 570                 


<210>  22
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  22
atggagttgc tgatccacag gtcaagtgca atcttcctaa ctcttgctgt taatgcattg       60

tacctcacct caagtcagaa cataactgag gagttttacc aatcgacatg tagtgcagtt      120

agcagaggtt attttagtgc tttaagaaca ggttggtata ccagtgtcat aacaatagaa      180

ttaagtaata taaaagaaac caaatgcaat ggaactgaca ctaaagtaaa acttataaaa      240

caagaattag ataagtataa gaatgcagta acagaattac agctacttat gcaaaacacg      300

ccagctgcca acaaccgggc cagaagagaa gcaccacagt acatgaacta cacaatcaat      360

accacaaaaa acctaaatgt atcaataagc aagaaaagga aacgaagatt tctgggcttc      420

ttgttaggtg taggatctgc aatagcaagt ggtatagctg tatccaaagt tttacacctt      480

gaaggagaag tgaacaaaat caaaaatgct ttgttgtcta caaacaaagc tgtagtcagt      540

ctatcaaatg gggtcagtgt tttaaccagc aaagtgttag atctcaagaa ttacataaat      600

aaccgattat tacccatagt aaatcaacag agctgtcgca tctccaacat tgaaacagtt      660

atagaattcc agcagatgaa tagcagattg ttggaaatca ccagagaatt tagtgttaat      720

gcaggtgtaa caacaccttt aagcacttac atgttaacaa acagtgagtt actatcattg      780

atcaatgata tgcctataac aaatgaccag aaaaaattaa tgtcaagcaa tgttcagata      840

gtaaggcaac aaagttattc tatcatgtct ataataaagg aagaagtcct tgcatatgtt      900

gtacagctac ctatctatgg tgtaatagat acaccttgct ggaaattaca cacatcacct      960

ctatgcacca ccaacatcaa agaaggatca aatatttgtt taacaaggac tgatagagga     1020

tggtattgtg ataatgcagg atcagtatcc ttcttcccac aggctgatac ttgcaaagta     1080

cagtccaatc gagtattttg tgacactatg aacagtttaa cattaccaag tgaagtcagc     1140

ctttgtaaca ctgacatatt caattccaag tatgactgca aaattatgac atcaaaaaca     1200

gacataagca gctcagtaat tacttctctt ggagctatag tgtcatgcta tggaaaaact     1260

aaatgcactg catccaataa aaatcgtggg attataaaga cattttctaa tggttgtgac     1320

tatgtgtcaa acaaaggagt agatactgtg tcagtgggca acactttata ctatgtaaac     1380

aagctggaag gcaaaaacct ttatgtaaaa ggggaaccta taataaatta ctatgatcct     1440

ctagtgtttc cttctgatga gtttgatgca tcaatatctc aagtcaatga aaaaatcaat     1500

caaagtttag cttttattcg tagatctgat gaattactac ataatgtaaa tactggcaaa     1560

tctactacaa atattatgat aactacaatt attatagtaa tcattgtagt attgttatca     1620

ttaatagcta ttggtttact gttgtattgc aaagccaaaa acacaccagt tacactaagc     1680

aaagaccaac taagtggaat caataatatt gcattcagca aatag                     1725


<210>  23
<211>  1725
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  23
auggaguugc ugauccacag gucaagugca aucuuccuaa cucuugcugu uaaugcauug       60

uaccucaccu caagucagaa cauaacugag gaguuuuacc aaucgacaug uagugcaguu      120

agcagagguu auuuuagugc uuuaagaaca gguugguaua ccagugucau aacaauagaa      180

uuaaguaaua uaaaagaaac caaaugcaau ggaacugaca cuaaaguaaa acuuauaaaa      240

caagaauuag auaaguauaa gaaugcagua acagaauuac agcuacuuau gcaaaacacg      300

ccagcugcca acaaccgggc cagaagagaa gcaccacagu acaugaacua cacaaucaau      360

accacaaaaa accuaaaugu aucaauaagc aagaaaagga aacgaagauu ucugggcuuc      420

uuguuaggug uaggaucugc aauagcaagu gguauagcug uauccaaagu uuuacaccuu      480

gaaggagaag ugaacaaaau caaaaaugcu uuguugucua caaacaaagc uguagucagu      540

cuaucaaaug gggucagugu uuuaaccagc aaaguguuag aucucaagaa uuacauaaau      600

aaccgauuau uacccauagu aaaucaacag agcugucgca ucuccaacau ugaaacaguu      660

auagaauucc agcagaugaa uagcagauug uuggaaauca ccagagaauu uaguguuaau      720

gcagguguaa caacaccuuu aagcacuuac auguuaacaa acagugaguu acuaucauug      780

aucaaugaua ugccuauaac aaaugaccag aaaaaauuaa ugucaagcaa uguucagaua      840

guaaggcaac aaaguuauuc uaucaugucu auaauaaagg aagaaguccu ugcauauguu      900

guacagcuac cuaucuaugg uguaauagau acaccuugcu ggaaauuaca cacaucaccu      960

cuaugcacca ccaacaucaa agaaggauca aauauuuguu uaacaaggac ugauagagga     1020

ugguauugug auaaugcagg aucaguaucc uucuucccac aggcugauac uugcaaagua     1080

caguccaauc gaguauuuug ugacacuaug aacaguuuaa cauuaccaag ugaagucagc     1140

cuuuguaaca cugacauauu caauuccaag uaugacugca aaauuaugac aucaaaaaca     1200

gacauaagca gcucaguaau uacuucucuu ggagcuauag ugucaugcua uggaaaaacu     1260

aaaugcacug cauccaauaa aaaucguggg auuauaaaga cauuuucuaa ugguugugac     1320

uaugugucaa acaaaggagu agauacugug ucagugggca acacuuuaua cuauguaaac     1380

aagcuggaag gcaaaaaccu uuauguaaaa ggggaaccua uaauaaauua cuaugauccu     1440

cuaguguuuc cuucugauga guuugaugca ucaauaucuc aagucaauga aaaaaucaau     1500

caaaguuuag cuuuuauucg uagaucugau gaauuacuac auaauguaaa uacuggcaaa     1560

ucuacuacaa auauuaugau aacuacaauu auuauaguaa ucauuguagu auuguuauca     1620

uuaauagcua uugguuuacu guuguauugc aaagccaaaa acacaccagu uacacuaagc     1680

aaagaccaac uaaguggaau caauaauauu gcauucagca aauag                     1725


<210>  24
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  24

Met Glu Leu Pro Ile Leu Lys Thr Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Leu Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Ser Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Asn Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Ile 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ala Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  25
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  25
atggagttgc caatcctcaa aacaaatgct attaccacaa tccttgctgc agtcacactc       60

tgcttcgctt ccagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt      120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa      180

ttaagtaata tcaaggaaaa taagtgtaat ggtacagatg ctaaggtaaa attaataaaa      240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca      300

ccagcagcca acagtcgagc cagaagagaa ctgccaagat ttatgaatta tacactcaac      360

aataccaaaa acaccaatgt aacattaagt aagaaaagga aaagaagatt tcttggattt      420

ttgttaggtg ttggatctgc aatcgccagt ggcattgccg tatccaaggt cctgcaccta      480

gaaggggaag tgaacaaaat caaaagtgct ctactatcca caaacaaggc tgtagtcagc      540

ttatctaatg gagtcagtgt cttaaccagc aaggtgttag acctcaaaaa ctatatagat      600

aaacagttgt tacctattgt taacaagcaa agctgcagca tatcaaacat tgaaactgtg      660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagagaatt tagtgttaat      720

gcaggtgtaa ctacacctgt aagcacttat atgttaacta atagtgagtt attatcatta      780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccagcaa tgttcaaata      840

gttagacagc aaagttactc tatcatgtca ataataaaag aggaagtctt agcatatgta      900

gtacaattac cactatatgg tgtaatagat actccttgtt ggaaactaca cacatcccct      960

ctatgtacaa ccaacacaaa ggaaggatcc aacatctgct taacaagaac cgacagagga     1020

tggtactgtg acaatgcagg atcagtatcc tttttcccac aagctgaaac atgtaaagtt     1080

caatcgaatc gggtattttg tgacacaatg aacagtttaa cattaccaag tgaggtaaat     1140

ctctgcaaca ttgacatatt caaccccaaa tatgattgca aaattatgac ttcaaaaaca     1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaacc     1260

aaatgtacag catccaataa aaatcgtggg atcataaaga cattctctaa cgggtgtgat     1320

tatgtatcaa ataagggggt ggatactgtg tctgtaggta atacattata ttatgtaaat     1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgatcca     1440

ttagtgttcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaaaattaat     1500

cagagtctag catttatccg taaatcagat gaattattac ataatgtaaa tgctggtaaa     1560

tccaccacaa atatcatgat aactaccata attatagtaa ttatagtaat attgttagca     1620

ttaattgcag ttggactgct tctatactgc aaggccagaa gcacaccagt cacattaagt     1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                     1725


<210>  26
<211>  1725
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  26
auggaguugc caauccucaa aacaaaugcu auuaccacaa uccuugcugc agucacacuc       60

ugcuucgcuu ccagucaaaa caucacugaa gaauuuuauc aaucaacaug cagugcaguu      120

agcaaaggcu aucuuagugc ucuaagaacu gguugguaua cuaguguuau aacuauagaa      180

uuaaguaaua ucaaggaaaa uaaguguaau gguacagaug cuaagguaaa auuaauaaaa      240

caagaauuag auaaauauaa aaaugcugua acagaauugc aguugcucau gcaaagcaca      300

ccagcagcca acagucgagc cagaagagaa cugccaagau uuaugaauua uacacucaac      360

aauaccaaaa acaccaaugu aacauuaagu aagaaaagga aaagaagauu ucuuggauuu      420

uuguuaggug uuggaucugc aaucgccagu ggcauugccg uauccaaggu ccugcaccua      480

gaaggggaag ugaacaaaau caaaagugcu cuacuaucca caaacaaggc uguagucagc      540

uuaucuaaug gagucagugu cuuaaccagc aagguguuag accucaaaaa cuauauagau      600

aaacaguugu uaccuauugu uaacaagcaa agcugcagca uaucaaacau ugaaacugug      660

auagaguucc aacaaaagaa caacagacua cuagagauua ccagagaauu uaguguuaau      720

gcagguguaa cuacaccugu aagcacuuau auguuaacua auagugaguu auuaucauua      780

aucaaugaua ugccuauaac aaaugaucag aaaaaguuaa uguccagcaa uguucaaaua      840

guuagacagc aaaguuacuc uaucauguca auaauaaaag aggaagucuu agcauaugua      900

guacaauuac cacuauaugg uguaauagau acuccuuguu ggaaacuaca cacauccccu      960

cuauguacaa ccaacacaaa ggaaggaucc aacaucugcu uaacaagaac cgacagagga     1020

ugguacugug acaaugcagg aucaguaucc uuuuucccac aagcugaaac auguaaaguu     1080

caaucgaauc ggguauuuug ugacacaaug aacaguuuaa cauuaccaag ugagguaaau     1140

cucugcaaca uugacauauu caaccccaaa uaugauugca aaauuaugac uucaaaaaca     1200

gauguaagca gcuccguuau cacaucucua ggagccauug ugucaugcua uggcaaaacc     1260

aaauguacag cauccaauaa aaaucguggg aucauaaaga cauucucuaa cgggugugau     1320

uauguaucaa auaagggggu ggauacugug ucuguaggua auacauuaua uuauguaaau     1380

aagcaagaag gcaaaagucu cuauguaaaa ggugaaccaa uaauaaauuu cuaugaucca     1440

uuaguguucc ccucugauga auuugaugca ucaauaucuc aagucaauga gaaaauuaau     1500

cagagucuag cauuuauccg uaaaucagau gaauuauuac auaauguaaa ugcugguaaa     1560

uccaccacaa auaucaugau aacuaccaua auuauaguaa uuauaguaau auuguuagca     1620

uuaauugcag uuggacugcu ucuauacugc aaggccagaa gcacaccagu cacauuaagu     1680

aaggaucaac ugagugguau aaauaauauu gcauuuagua acuga                     1725


<210>  27
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  27

Met Glu Leu Leu Ile His Arg Ser Ser Ala Ile Phe Leu Thr Leu Ala 
1               5                   10                  15      


Ile Asn Ala Leu Tyr Leu Thr Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Phe Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Thr Lys Cys Asn Gly Thr Asp Thr Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Asn Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Ala Pro 
            100                 105                 110         


Gln Tyr Met Asn Tyr Thr Ile Asn Thr Thr Lys Asn Leu Asn Val Ser 
        115                 120                 125             


Ile Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asn Asn Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Gln Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Ser Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Ile Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Ile Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Asp Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Ser Leu Cys Asn Thr 
    370                 375                 380                 


Asp Ile Phe Asn Ser Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Ile Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly 
    450                 455                 460                 


Lys Asn Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Thr Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Ala Ile Ile Ile Val Ile Ile Val Val Leu Leu Ser Leu Ile Ala Ile 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Lys Asn Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Lys 
                565                 570                 


<210>  28
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  28
atggagttgc tgatccatag atcaagtgca atcttcctaa ctcttgctat taatgcattg       60

tacctcacct caagtcagaa cataactgag gagttttacc aatcgacatg tagtgcagtt      120

agcagaggtt actttagtgc tttaagaaca ggttggtata ccagtgtcat aacaatagaa      180

ttaagtaata taaaagaaac caaatgcaat ggaactgaca ctaaagtaaa acttataaaa      240

caagaattag ataagtataa gaatgcagta acagaattac agttacttat gcaaaacaca      300

ccagctgcca acaaccgagc cagaagagaa gcaccacagt atatgaacta cacaatcaat      360

accactaaaa acctaaatgt atcaataagc aagaagagga aacgaagatt tctgggcttc      420

ttgttaggtg taggatctgc aatagcaagt ggcatagctg tatccaaagt tctacacctt      480

gaaggagaag tgaacaagat caaaaatgct ttgctgtcta caaacaaagc tgtagtcagt      540

ctatcaaatg gggtcagtgt tttaaccagc aaagtgttag atctcaagaa ttatataaac      600

aaccaattat tacctatagt aaatcaacag agttgtcgca tctccaacat tgaaacagtt      660

atagaattcc agcagaagaa cagcagattg ttggaaatca ccagagaatt tagtgtcaat      720

gcaggtgtaa cgacaccttt aagcacttac atgttaacaa acagtgagtt actatcatta      780

atcaatgata tgcctataac aaatgatcag aagaaattaa tgtcaagcaa tgttcagata      840

gtaaggcaac aaagttattc tatcatgtct ataataaagg aagaagtcct cgcatatgtt      900

gtacagctac ctatctatgg tgtaatagat acaccttgct ggaaattaca cacatcacct      960

ctgtgcacca ccaacatcaa agaaggatca aatatttgtt taacaaggac tgatagagga     1020

tggtactgtg ataatgcagg atcagtatcc ttctttccac aggctgacac ttgtaaagta     1080

cagtccaatc gagtattttg tgacactatg aacagtttga cattaccaag tgaagtcagc     1140

ctttgtaaca ctgacatatt caattccaag tatgactgca aaattatgac atcaaaaaca     1200

gacataagca gctcagtaat tacttctcta ggagctatag tgtcatgcta tggtaaaact     1260

aaatgcactg catccaacaa aaatcgtgga attataaaga cattttctaa tggttgtgat     1320

tatgtgtcaa acaaaggagt agatactgta tcagtaggca acactttata ctatgtcaac     1380

aagctggaag gcaaaaacct ttatgtaaaa ggggaaccta taataaatta ctatgaccct     1440

ctagtgtttc cttctgatga gtttgatgca tcaatatctc aagtcaatga aaaaattaat     1500

caaagtttag cttttattcg tagatccgat gaattattac ataatgtaaa tactggaaaa     1560

tctactacaa atattatgat aactgcaatt attatagtaa tcattgtagt attgttatca     1620

ttaatagcta ttggtttact gttgtattgc aaagccaaaa acacaccagt tacactaagc     1680

aaagaccaac taagtggaat caacaacatt gcattcagca aatag                     1725


<210>  29
<211>  1725
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  29
auggaguugc ugauccauag aucaagugca aucuuccuaa cucuugcuau uaaugcauug       60

uaccucaccu caagucagaa cauaacugag gaguuuuacc aaucgacaug uagugcaguu      120

agcagagguu acuuuagugc uuuaagaaca gguugguaua ccagugucau aacaauagaa      180

uuaaguaaua uaaaagaaac caaaugcaau ggaacugaca cuaaaguaaa acuuauaaaa      240

caagaauuag auaaguauaa gaaugcagua acagaauuac aguuacuuau gcaaaacaca      300

ccagcugcca acaaccgagc cagaagagaa gcaccacagu auaugaacua cacaaucaau      360

accacuaaaa accuaaaugu aucaauaagc aagaagagga aacgaagauu ucugggcuuc      420

uuguuaggug uaggaucugc aauagcaagu ggcauagcug uauccaaagu ucuacaccuu      480

gaaggagaag ugaacaagau caaaaaugcu uugcugucua caaacaaagc uguagucagu      540

cuaucaaaug gggucagugu uuuaaccagc aaaguguuag aucucaagaa uuauauaaac      600

aaccaauuau uaccuauagu aaaucaacag aguugucgca ucuccaacau ugaaacaguu      660

auagaauucc agcagaagaa cagcagauug uuggaaauca ccagagaauu uagugucaau      720

gcagguguaa cgacaccuuu aagcacuuac auguuaacaa acagugaguu acuaucauua      780

aucaaugaua ugccuauaac aaaugaucag aagaaauuaa ugucaagcaa uguucagaua      840

guaaggcaac aaaguuauuc uaucaugucu auaauaaagg aagaaguccu cgcauauguu      900

guacagcuac cuaucuaugg uguaauagau acaccuugcu ggaaauuaca cacaucaccu      960

cugugcacca ccaacaucaa agaaggauca aauauuuguu uaacaaggac ugauagagga     1020

ugguacugug auaaugcagg aucaguaucc uucuuuccac aggcugacac uuguaaagua     1080

caguccaauc gaguauuuug ugacacuaug aacaguuuga cauuaccaag ugaagucagc     1140

cuuuguaaca cugacauauu caauuccaag uaugacugca aaauuaugac aucaaaaaca     1200

gacauaagca gcucaguaau uacuucucua ggagcuauag ugucaugcua ugguaaaacu     1260

aaaugcacug cauccaacaa aaaucgugga auuauaaaga cauuuucuaa ugguugugau     1320

uaugugucaa acaaaggagu agauacugua ucaguaggca acacuuuaua cuaugucaac     1380

aagcuggaag gcaaaaaccu uuauguaaaa ggggaaccua uaauaaauua cuaugacccu     1440

cuaguguuuc cuucugauga guuugaugca ucaauaucuc aagucaauga aaaaauuaau     1500

caaaguuuag cuuuuauucg uagauccgau gaauuauuac auaauguaaa uacuggaaaa     1560

ucuacuacaa auauuaugau aacugcaauu auuauaguaa ucauuguagu auuguuauca     1620

uuaauagcua uugguuuacu guuguauugc aaagccaaaa acacaccagu uacacuaagc     1680

aaagaccaac uaaguggaau caacaacauu gcauucagca aauag                     1725


<210>  30
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  30

Gln Asn Ile Thr Glu Glu Phe Tyr Gln Ser Thr Cys Ser Ala Val Ser 
1               5                   10                  15      


Lys Gly Tyr Leu Ser Ala Leu Arg Thr Gly Trp Tyr Thr Ser Val Ile 
            20                  25                  30          


Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp 
        35                  40                  45              


Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala 
    50                  55                  60                  


Val Thr Glu Leu Gln Leu Leu Met Gln Ser Thr Pro Ala Cys Asn Ser 
65                  70                  75                  80  


Arg Ala Arg Arg 
                


<210>  31
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  31

Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Cys Ala Ser Gly Ile 
1               5                   10                  15      


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
            20                  25                  30          


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
        35                  40                  45              


Val Ser Val Leu Thr Ile Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
    50                  55                  60                  


Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
                85                  90                  95      


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
            100                 105                 110         


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
        115                 120                 125             


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Ser Asn Val Gln Ile 
    130                 135                 140                 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
145                 150                 155                 160 


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
                165                 170                 175     


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
            180                 185                 190         


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
        195                 200                 205             


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
    210                 215                 220                 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro 
225                 230                 235                 240 


Ser Glu Val Asn Leu Cys Asn Ile Asp Ile Phe Asn Pro Lys Tyr Asp 
                245                 250                 255     


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
            260                 265                 270         


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
        275                 280                 285             


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
    290                 295                 300                 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
305                 310                 315                 320 


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
                325                 330                 335     


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Ser Glu Phe 
            340                 345                 350         


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
        355                 360                 365             


Phe Ile Arg Lys Ser Asp Glu Leu Leu 
    370                 375         


<210>  32
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  32

Gln Asn Ile Thr Glu Glu Phe Tyr Gln Ser Thr Cys Ser Ala Val Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Ser Ala Leu Arg Thr Gly Trp Tyr Thr Ser Val Ile 
            20                  25                  30          


Thr Ile Glu Leu Ser Asn Ile Lys Glu Thr Lys Cys Asn Gly Thr Asp 
        35                  40                  45              


Thr Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala 
    50                  55                  60                  


Val Thr Glu Leu Gln Leu Leu Met Gln Asn Thr Pro Ala Cys Asn Asn 
65                  70                  75                  80  


Arg Ala Arg Arg 
                


<210>  33
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  33

Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Cys Ala Ser Gly Ile 
1               5                   10                  15      


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
            20                  25                  30          


Asn Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
        35                  40                  45              


Val Ser Val Leu Thr Ile Lys Val Leu Asp Leu Lys Asn Tyr Ile Asn 
    50                  55                  60                  


Asn Gln Leu Leu Pro Ile Val Asn Gln Gln Ser Cys Arg Ile Ser Asn 
65                  70                  75                  80  


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Ser Arg Leu Leu Glu 
                85                  90                  95      


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Leu Ser 
            100                 105                 110         


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
        115                 120                 125             


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Ser Asn Val Gln Ile 
    130                 135                 140                 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
145                 150                 155                 160 


Leu Ala Tyr Val Val Gln Leu Pro Ile Tyr Gly Val Ile Asp Thr Pro 
                165                 170                 175     


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Ile Lys Glu 
            180                 185                 190         


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
        195                 200                 205             


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Asp Thr Cys Lys Val 
    210                 215                 220                 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro 
225                 230                 235                 240 


Ser Glu Val Ser Leu Cys Asn Thr Asp Ile Phe Asn Ser Lys Tyr Asp 
                245                 250                 255     


Cys Lys Ile Met Thr Ser Lys Thr Asp Ile Ser Ser Ser Val Ile Thr 
            260                 265                 270         


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
        275                 280                 285             


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
    290                 295                 300                 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
305                 310                 315                 320 


Tyr Tyr Val Asn Lys Leu Glu Gly Lys Asn Leu Tyr Val Lys Gly Glu 
                325                 330                 335     


Pro Ile Ile Asn Tyr Tyr Asp Pro Leu Val Phe Pro Ser Ser Glu Phe 
            340                 345                 350         


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
        355                 360                 365             


Phe Ile Arg Arg Ser Asp Glu Leu Leu 
    370                 375         


<210>  34
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  34

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Cys Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Cys Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ile Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Ser Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Ser Ala Ile Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
        515                 520                 525             


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
    530                 535                 540                 


Gly Gly Leu Val Pro Arg Gly Ser His His His His His His Gly Ser 
545                 550                 555                 560 


Trp Ser His Pro Gln Phe Glu Lys 
                565             


<210>  35
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  35
atggaacttc tgatcctgaa agccaacgcg attaccacta tcctgactgc cgtcaccttc       60

tgcttcgcat cgggacagaa cattaccgag gagttctacc agtccacctg ttcggcggtg      120

tccaagggtt acctctcggc cctgagaact ggctggtaca ccagcgtgat tactatcgag      180

ctgagcaaca tcaaggagaa caagtgcaat ggaacggacg cgaaggtcaa gctgattaag      240

caggaactcg ataagtacaa gaacgccgtg accgagctcc agctgctgat gcaatcgacc      300

cctgcctgta acaacagagc tcgccgggaa ctgccgcgct tcatgaatta caccctcaac      360

aacgcgaaga aaaccaacgt gaccctgtcc aagaagcgca agcggaggtt cctgggattc      420

ctgttgggcg tgggctccgc atgtgcatcc ggagtggccg tgtccaaagt gctgcatctg      480

gagggggaag tgaacaagat caagtccgcc ctcctgtcaa ctaataaggc ggtggtgtcc      540

ctgagcaacg gagtcagcgt gctgacaatc aaggtcctgg acctcaagaa ctacatcgac      600

aagcagctgt tgcccatcgt caacaagcag tcatgctcga ttagcaatat cgaaaccgtg      660

attgagttcc agcagaagaa caacagactg ctcgaaatta cccgggagtt ttccgtgaac      720

gccggagtga ccactcctgt gtccacctac atgcttacga actccgaact gctcagcctc      780

atcaacgata tgccgatcac taacgaccag aagaagttga tgagcaacaa tgtgcagatc      840

gtgcgccaac agtcctactc aatcatgtca attatcaagg aggaagtgct cgcctatgtg      900

gtgcaattgc ctctgtacgg agtcatcgac acaccctgct ggaagctgca cactagccca      960

ctctgtacga ccaacaccaa ggaaggttcc aacatctgcc tgactaggac cgatcggggc     1020

tggtattgcg ataatgctgg gtccgtgagc ttcttcccgc aagccgagac ttgcaaagtg     1080

cagtcaaacc gcgtgttctg tgacaccatg aacagcctga ccctgccatc cgaagtcaac     1140

ctctgcaacg tggacatctt taacccgaaa tacgactgca agattatgac ctccaagacc     1200

gacgtcagca gctctgtcat cactagcctg ggagctattg tgtcctgcta cggaaagacc     1260

aaatgcactg cctcgaacaa gaacagaggc atcatcaaga ccttcagcaa cggctgtgac     1320

tacgtgtcca acaagggagt ggacaccgtg tccgtcggga acaccctgta ctacgtgaac     1380

aagcaggagg ggaagtcgct ctacgtcaag ggggaaccga ttatcaattt ctacgacccc     1440

ctggtgttcc cttcctccga gttcgatgcc tccatatccc aagtcaacga gaagatcaac     1500

cagtctcttg ccttcatccg gaagtcggac gaactgctgt ccgccatcgg tggctatatt     1560

ccggaagccc ccagggatgg acaggcctac gtgcggaagg atggagaatg ggtgcttttg     1620

tccaccttcc tgggcggtct ggtgccccgc ggctcacacc atcatcacca ccacggttcg     1680

tggtcccacc ctcaatttga gaagtga                                         1707


<210>  36
<211>  1707
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  36
auggaacuuc ugauccugaa agccaacgcg auuaccacua uccugacugc cgucaccuuc       60

ugcuucgcau cgggacagaa cauuaccgag gaguucuacc aguccaccug uucggcggug      120

uccaaggguu accucucggc ccugagaacu ggcugguaca ccagcgugau uacuaucgag      180

cugagcaaca ucaaggagaa caagugcaau ggaacggacg cgaaggucaa gcugauuaag      240

caggaacucg auaaguacaa gaacgccgug accgagcucc agcugcugau gcaaucgacc      300

ccugccugua acaacagagc ucgccgggaa cugccgcgcu ucaugaauua cacccucaac      360

aacgcgaaga aaaccaacgu gacccugucc aagaagcgca agcggagguu ccugggauuc      420

cuguugggcg ugggcuccgc augugcaucc ggaguggccg uguccaaagu gcugcaucug      480

gagggggaag ugaacaagau caaguccgcc cuccugucaa cuaauaaggc gguggugucc      540

cugagcaacg gagucagcgu gcugacaauc aagguccugg accucaagaa cuacaucgac      600

aagcagcugu ugcccaucgu caacaagcag ucaugcucga uuagcaauau cgaaaccgug      660

auugaguucc agcagaagaa caacagacug cucgaaauua cccgggaguu uuccgugaac      720

gccggaguga ccacuccugu guccaccuac augcuuacga acuccgaacu gcucagccuc      780

aucaacgaua ugccgaucac uaacgaccag aagaaguuga ugagcaacaa ugugcagauc      840

gugcgccaac aguccuacuc aaucauguca auuaucaagg aggaagugcu cgccuaugug      900

gugcaauugc cucuguacgg agucaucgac acacccugcu ggaagcugca cacuagccca      960

cucuguacga ccaacaccaa ggaagguucc aacaucugcc ugacuaggac cgaucggggc     1020

ugguauugcg auaaugcugg guccgugagc uucuucccgc aagccgagac uugcaaagug     1080

cagucaaacc gcguguucug ugacaccaug aacagccuga cccugccauc cgaagucaac     1140

cucugcaacg uggacaucuu uaacccgaaa uacgacugca agauuaugac cuccaagacc     1200

gacgucagca gcucugucau cacuagccug ggagcuauug uguccugcua cggaaagacc     1260

aaaugcacug ccucgaacaa gaacagaggc aucaucaaga ccuucagcaa cggcugugac     1320

uacgugucca acaagggagu ggacaccgug uccgucggga acacccugua cuacgugaac     1380

aagcaggagg ggaagucgcu cuacgucaag ggggaaccga uuaucaauuu cuacgacccc     1440

cugguguucc cuuccuccga guucgaugcc uccauauccc aagucaacga gaagaucaac     1500

cagucucuug ccuucauccg gaagucggac gaacugcugu ccgccaucgg uggcuauauu     1560

ccggaagccc ccagggaugg acaggccuac gugcggaagg auggagaaug ggugcuuuug     1620

uccaccuucc ugggcggucu ggugccccgc ggcucacacc aucaucacca ccacgguucg     1680

uggucccacc cucaauuuga gaaguga                                         1707


<210>  37
<211>  13476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide sequence

<400>  37
taatacgact cactatagat aggcggcgca tgagagaagc ccagaccaat tacctaccca       60

aaatggagaa agttcacgtt gacatcgagg aagacagccc attcctcaga gctttgcagc      120

ggagcttccc gcagtttgag gtagaagcca agcaggtcac tgataatgac catgctaatg      180

ccagagcgtt ttcgcatctg gcttcaaaac tgatcgaaac ggaggtggac ccatccgaca      240

cgatccttga cattggaagt gcgcccgccc gcagaatgta ttctaagcac aagtatcatt      300

gtatctgtcc gatgagatgt gcggaagatc cggacagatt gtataagtat gcaactaagc      360

tgaagaaaaa ctgtaaggaa ataactgata aggaattgga caagaaaatg aaggagctcg      420

ccgccgtcat gagcgaccct gacctggaaa ctgagactat gtgcctccac gacgacgagt      480

cgtgtcgcta cgaagggcaa gtcgctgttt accaggatgt atacgcggtt gacggaccga      540

caagtctcta tcaccaagcc aataagggag ttagagtcgc ctactggata ggctttgaca      600

ccaccccttt tatgtttaag aacttggctg gagcatatcc atcatactct accaactggg      660

ccgacgaaac cgtgttaacg gctcgtaaca taggcctatg cagctctgac gttatggagc      720

ggtcacgtag agggatgtcc attcttagaa agaagtattt gaaaccatcc aacaatgttc      780

tattctctgt tggctcgacc atctaccacg agaagaggga cttactgagg agctggcacc      840

tgccgtctgt atttcactta cgtggcaagc aaaattacac atgtcggtgt gagactatag      900

ttagttgcga cgggtacgtc gttaaaagaa tagctatcag tccaggcctg tatgggaagc      960

cttcaggcta tgctgctacg atgcaccgcg agggattctt gtgctgcaaa gtgacagaca     1020

cattgaacgg ggagagggtc tcttttcccg tgtgcacgta tgtgccagct acattgtgtg     1080

accaaatgac tggcatactg gcaacagatg tcagtgcgga cgacgcgcaa aaactgctgg     1140

ttgggctcaa ccagcgtata gtcgtcaacg gtcgcaccca gagaaacacc aataccatga     1200

aaaattacct tttgcccgta gtggcccagg catttgctag gtgggcaaag gaatataagg     1260

aagatcaaga agatgaaagg ccactaggac tacgagatag acagttagtc atggggtgtt     1320

gttgggcttt tagaaggcac aagataacat ctatttataa gcgcccggat acccaaacca     1380

tcatcaaagt gaacagcgat ttccactcat tcgtgctgcc caggataggc agtaacacat     1440

tggagatcgg gctgagaaca agaatcagga aaatgttaga ggagcacaag gagccgtcac     1500

ctctcattac cgccgaggac gtacaagaag ctaagtgcgc agccgatgag gctaaggagg     1560

tgcgtgaagc cgaggagttg cgcgcagctc taccaccttt ggcagctgat gttgaggagc     1620

ccactctgga agccgatgtc gacttgatgt tacaagaggc tggggccggc tcagtggaga     1680

cacctcgtgg cttgataaag gttaccagct acgatggcga ggacaagatc ggctcttacg     1740

ctgtgctttc tccgcaggct gtactcaaga gtgaaaaatt atcttgcatc caccctctcg     1800

ctgaacaagt catagtgata acacactctg gccgaaaagg gcgttatgcc gtggaaccat     1860

accatggtaa agtagtggtg ccagagggac atgcaatacc cgtccaggac tttcaagctc     1920

tgagtgaaag tgccaccatt gtgtacaacg aacgtgagtt cgtaaacagg tacctgcacc     1980

atattgccac acatggagga gcgctgaaca ctgatgaaga atattacaaa actgtcaagc     2040

ccagcgagca cgacggcgaa tacctgtacg acatcgacag gaaacagtgc gtcaagaaag     2100

aactagtcac tgggctaggg ctcacaggcg agctggtgga tcctcccttc catgaattcg     2160

cctacgagag tctgagaaca cgaccagccg ctccttacca agtaccaacc ataggggtgt     2220

atggcgtgcc aggatcaggc aagtctggca tcattaaaag cgcagtcacc aaaaaagatc     2280

tagtggtgag cgccaagaaa gaaaactgtg cagaaattat aagggacgtc aagaaaatga     2340

aagggctgga cgtcaatgcc agaactgtgg actcagtgct cttgaatgga tgcaaacacc     2400

ccgtagagac cctgtatatt gacgaagctt ttgcttgtca tgcaggtact ctcagagcgc     2460

tcatagccat tataagacct aaaaaggcag tgctctgcgg ggatcccaaa cagtgcggtt     2520

tttttaacat gatgtgcctg aaagtgcatt ttaaccacga gatttgcaca caagtcttcc     2580

acaaaagcat ctctcgccgt tgcactaaat ctgtgacttc ggtcgtctca accttgtttt     2640

acgacaaaaa aatgagaacg acgaatccga aagagactaa gattgtgatt gacactaccg     2700

gcagtaccaa acctaagcag gacgatctca ttctcacttg tttcagaggg tgggtgaagc     2760

agttgcaaat agattacaaa ggcaacgaaa taatgacggc agctgcctct caagggctga     2820

cccgtaaagg tgtgtatgcc gttcggtaca aggtgaatga aaatcctctg tacgcaccca     2880

cctcagaaca tgtgaacgtc ctactgaccc gcacggagga ccgcatcgtg tggaaaacac     2940

tagccggcga cccatggata aaaacactga ctgccaagta ccctgggaat ttcactgcca     3000

cgatagagga gtggcaagca gagcatgatg ccatcatgag gcacatcttg gagagaccgg     3060

accctaccga cgtcttccag aataaggcaa acgtgtgttg ggccaaggct ttagtgccgg     3120

tgctgaagac cgctggcata gacatgacca ctgaacaatg gaacactgtg gattattttg     3180

aaacggacaa agctcactca gcagagatag tattgaacca actatgcgtg aggttctttg     3240

gactcgatct ggactccggt ctattttctg cacccactgt tccgttatcc attaggaata     3300

atcactggga taactccccg tcgcctaaca tgtacgggct gaataaagaa gtggtccgtc     3360

agctctctcg caggtaccca caactgcctc gggcagttgc cactggaaga gtctatgaca     3420

tgaacactgg tacactgcgc aattatgatc cgcgcataaa cctagtacct gtaaacagaa     3480

gactgcctca tgctttagtc ctccaccata atgaacaccc acagagtgac ttttcttcat     3540

tcgtcagcaa attgaagggc agaactgtcc tggtggtcgg ggaaaagttg tccgtcccag     3600

gcaaaatggt tgactggttg tcagaccggc ctgaggctac cttcagagct cggctggatt     3660

taggcatccc aggtgatgtg cccaaatatg acataatatt tgttaatgtg aggaccccat     3720

ataaatacca tcactatcag cagtgtgaag accatgccat taagcttagc atgttgacca     3780

agaaagcttg tctgcatctg aatcccggcg gaacctgtgt cagcataggt tatggttacg     3840

ctgacagggc cagcgaaagc atcattggtg ctatagcgcg gcagttcaag ttttcccggg     3900

tatgcaaacc gaaatcctca cttgaagaga cggaagttct gtttgtattc attgggtacg     3960

atcgcaaggc ccgtacgcac aatccttaca agctttcatc aaccttgacc aacatttata     4020

caggttccag actccacgaa gccggatgtg caccctcata tcatgtggtg cgaggggata     4080

ttgccacggc caccgaagga gtgattataa atgctgctaa cagcaaagga caacctggcg     4140

gaggggtgtg cggagcgctg tataagaaat tcccggaaag cttcgattta cagccgatcg     4200

aagtaggaaa agcgcgactg gtcaaaggtg cagctaaaca tatcattcat gccgtaggac     4260

caaacttcaa caaagtttcg gaggttgaag gtgacaaaca gttggcagag gcttatgagt     4320

ccatcgctaa gattgtcaac gataacaatt acaagtcagt agcgattcca ctgttgtcca     4380

ccggcatctt ttccgggaac aaagatcgac taacccaatc attgaaccat ttgctgacag     4440

ctttagacac cactgatgca gatgtagcca tatactgcag ggacaagaaa tgggaaatga     4500

ctctcaagga agcagtggct aggagagaag cagtggagga gatatgcata tccgacgact     4560

cttcagtgac agaacctgat gcagagctgg tgagggtgca tccgaagagt tctttggctg     4620

gaaggaaggg ctacagcaca agcgatggca aaactttctc atatttggaa gggaccaagt     4680

ttcaccaggc ggccaaggat atagcagaaa ttaatgccat gtggcccgtt gcaacggagg     4740

ccaatgagca ggtatgcatg tatatcctcg gagaaagcat gagcagtatt aggtcgaaat     4800

gccccgtcga agagtcggaa gcctccacac cacctagcac gctgccttgc ttgtgcatcc     4860

atgccatgac tccagaaaga gtacagcgcc taaaagcctc acgtccagaa caaattactg     4920

tgtgctcatc ctttccattg ccgaagtata gaatcactgg tgtgcagaag atccaatgct     4980

cccagcctat attgttctca ccgaaagtgc ctgcgtatat tcatccaagg aagtatctcg     5040

tggaaacacc accggtagac gagactccgg agccatcggc agagaaccaa tccacagagg     5100

ggacacctga acaaccacca cttataaccg aggatgagac caggactaga acgcctgagc     5160

cgatcatcat cgaagaggaa gaagaggata gcataagttt gctgtcagat ggcccgaccc     5220

accaggtgct gcaagtcgag gcagacattc acgggccgcc ctctgtatct agctcatcct     5280

ggtccattcc tcatgcatcc gactttgatg tggacagttt atccatactt gacaccctgg     5340

agggagctag cgtgaccagc ggggcaacgt cagccgagac taactcttac ttcgcaaaga     5400

gtatggagtt tctggcgcga ccggtgcctg cgcctcgaac agtattcagg aaccctccac     5460

atcccgctcc gcgcacaaga acaccgtcac ttgcacccag cagggcctgc tcgagaacca     5520

gcctagtttc caccccgcca ggcgtgaata gggtgatcac tagagaggag ctcgaggcgc     5580

ttaccccgtc acgcactcct agcaggtcgg tctcgagaac cagcctggtc tccaacccgc     5640

caggcgtaaa tagggtgatt acaagagagg agtttgaggc gttcgtagca caacaacaat     5700

gacggtttga tgcgggtgca tacatctttt cctccgacac cggtcaaggg catttacaac     5760

aaaaatcagt aaggcaaacg gtgctatccg aagtggtgtt ggagaggacc gaattggaga     5820

tttcgtatgc cccgcgcctc gaccaagaaa aagaagaatt actacgcaag aaattacagt     5880

taaatcccac acctgctaac agaagcagat accagtccag gaaggtggag aacatgaaag     5940

ccataacagc tagacgtatt ctgcaaggcc tagggcatta tttgaaggca gaaggaaaag     6000

tggagtgcta ccgaaccctg catcctgttc ctttgtattc atctagtgtg aaccgtgcct     6060

tttcaagccc caaggtcgca gtggaagcct gtaacgccat gttgaaagag aactttccga     6120

ctgtggcttc ttactgtatt attccagagt acgatgccta tttggacatg gttgacggag     6180

cttcatgctg cttagacact gccagttttt gccctgcaaa gctgcgcagc tttccaaaga     6240

aacactccta tttggaaccc acaatacgat cggcagtgcc ttcagcgatc cagaacacgc     6300

tccagaacgt cctggcagct gccacaaaaa gaaattgcaa tgtcacgcaa atgagagaat     6360

tgcccgtatt ggattcggcg gcctttaatg tggaatgctt caagaaatat gcgtgtaata     6420

atgaatattg ggaaacgttt aaagaaaacc ccatcaggct tactgaagaa aacgtggtaa     6480

attacattac caaattaaaa ggaccaaaag ctgctgctct ttttgcgaag acacataatt     6540

tgaatatgtt gcaggacata ccaatggaca ggtttgtaat ggacttaaag agagacgtga     6600

aagtgactcc aggaacaaaa catactgaag aacggcccaa ggtacaggtg atccaggctg     6660

ccgatccgct agcaacagcg tatctgtgcg gaatccaccg agagctggtt aggagattaa     6720

atgcggtcct gcttccgaac attcatacac tgtttgatat gtcggctgaa gactttgacg     6780

ctattatagc cgagcacttc cagcctgggg attgtgttct ggaaactgac atcgcgtcgt     6840

ttgataaaag tgaggacgac gccatggctc tgaccgcgtt aatgattctg gaagacttag     6900

gtgtggacgc agagctgttg acgctgattg aggcggcttt cggcgaaatt tcatcaatac     6960

atttgcccac taaaactaaa tttaaattcg gagccatgat gaaatctgga atgttcctca     7020

cactgtttgt gaacacagtc attaacattg taatcgcaag cagagtgttg agagaacggc     7080

taaccggatc accatgtgca gcattcattg gagatgacaa tatcgtgaaa ggagtcaaat     7140

cggacaaatt aatggcagac aggtgcgcca cctggttgaa tatggaagtc aagattatag     7200

atgctgtggt gggcgagaaa gcgccttatt tctgtggagg gtttattttg tgtgactccg     7260

tgaccggcac agcgtgccgt gtggcagacc ccctaaaaag gctgtttaag cttggcaaac     7320

ctctggcagc agacgatgaa catgatgatg acaggagaag ggcattgcat gaagagtcaa     7380

cacgctggaa ccgagtgggt attctttcag agctgtgcaa ggcagtagaa tcaaggtatg     7440

aaaccgtagg aacttccatc atagttatgg ccatgactac tctagctagc agtgttaaat     7500

cattcagcta cctgagaggg gcccctataa ctctctacgg ctaacctgaa tggactacga     7560

catagtctag tccgccaaga tatcgcacca tgaagtgcct gctgtacctg gccttcctgt     7620

tcatcggcgt gaactgcaag tttaccatcg tgttccctca caaccagaaa ggcaactgga     7680

agaacgtgcc cagcaactac cactactgcc ccagcagcag cgacctgaac tggcacaatg     7740

acctgatcgg cacagccctg caagtgaaga tgcccaagag ccacaaggcc atccaggccg     7800

atggatggat gtgccacgcc agcaaatggg tcaccacctg tgacttccgt tggtacggcc     7860

ccaagtacat cacccacagc atccgcagct tcacccctag cgtggaacag tgcaaagaga     7920

gcatcgagca gaccaagcaa ggcacctggc tgaaccctgg attcccacct cagagctgtg     7980

gctacgccac tgtgacagat gccgaggccg tgatcgtgca agtgacacct catcacgtgc     8040

tggtggacga gtacacaggc gagtgggtcg acagccagtt catcaacggc aagtgctcca     8100

actacatctg ccccaccgtg cacaacagca ccacctggca cagcgactac aaagtgaagg     8160

gcctgtgcga cagcaacctg atcagcatgg acatcacctt tttcagcgag gacggcgagc     8220

tgagcagcct gggaaaagaa ggcaccggct tcagaagcaa ctacttcgcc tatgagacag     8280

gcggcaaggc ctgcaagatg cagtattgca agcactgggg cgtcagactg cctagcggag     8340

tttggttcga gatggccgac aaggacctgt ttgccgccgc tagattccct gagtgtcctg     8400

agggcagcag catctctgcc cctagccaga catctgtgga cgtgtccctg atccaggacg     8460

tggaacggat cctggactac agcctgtgcc aagagacatg gtccaagatc agagccggcc     8520

tgcctatcag ccctgtggac ctgtcttatc tggcccctaa gaaccctggc accggacctg     8580

ccttcaccat catcaatggc accctgaagt actttgagac acggtacatc cgcgtggaca     8640

ttgccgctcc tatcctgagc agaatggtcg gaatgatcag cggcaccacc accgagaggg     8700

aactgtggga tgattgggcc ccttacgagg atgtggaaat cggccctaac ggcgtgctga     8760

gaacaagcag cggctacaag ttcccactgt acatgatcgg ccacggcatg ctggacagcg     8820

atctgcacct gtctagcaag gcccaggtgt tcgagcaccc tcacattcag gatgccgcca     8880

gccagctgcc tgatgacgag agcctgttct ttggcgatac cggcctgagc aagaacccca     8940

tcgaactggt ggaaggctgg ttcagcagct ggaagtcctc tatcgccagc ttcttcttca     9000

tcatcgggct gattatcggc ctgttcctgg tgctgagagt gggcatccac ctgtgcatca     9060

agctgaagca caccaagaag cggcagatct acaccgacat cgagatgaac cggctgggca     9120

agtgatgaat acagcagcaa ttggcaagct gcttacatag aactcgcggc gattggcatg     9180

ccgccttaaa atttttattt tatttttctt ttcttttccg aatcggattt tgtttttaat     9240

atttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagaaga gcatgcaagc     9300

ttggctgttt tggcggatga gagaagattt tcagcctgat acagattaaa tcagaacgca     9360

gaagcggtct gataaaacag aatttgcctg gcggcagtag cgcggtggtc ccacctgacc     9420

ccatgccgaa ctcagaagtg aaacgccgta gcgccgatgg tagtgtgggg tctccccatg     9480

cgagagtagg gaactgccag gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc     9540

tttcgtttta tctgttgttt gtcggtgaac gctctcctga gtaggacaaa tccgccggga     9600

gcggatttga acgttgcgaa gcaacggccc ggagggtggc gggcaggacg cccgccataa     9660

actgccaggc atcaaattaa gcagaaggcc atcctgacgg atggcctttt tgcgtttcta     9720

caaactcttt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     9780

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     9840

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     9900

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     9960

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat    10020

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtgttgacg ccgggcaaga    10080

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac    10140

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat    10200

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac    10260

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct    10320

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgcagcaa tggcaacaac    10380

gttgccgtgc tgctgaagtt gcccgcaaca gagagtggaa ccaaccggtg ataccacgat    10440

actatgactg agagtcaacg ccatgagcgg cctcatttct tattctgagt tacaacagtc    10500

cgcaccgctg tccggtagct ccttccggtg ggcgcggggc atgactatcg tcgccgcact    10560

tatgactgtc ttctttatca tgcaactcgt aggacaggtg ccggcagcgc ccaacagtcc    10620

cccggccacg gggcctgcca ccatacccac gccgaaacaa gcgccctgca ccattatgtt    10680

ccggatctgc atcgcaggat gctgctggct accctgtgga acacctacat ctgtattaac    10740

gaagcgctaa ccgtttttat caggctctgg gaggcagaat aaatgatcat atcgtcaatt    10800

attacctcca cggggagagc ctgagcaaac tggcctcagg catttgagaa gcacacggtc    10860

acactgcttc cggtagtcaa taaaccggta aaccagcaat agacataagc ggctatttaa    10920

cgaccctgcc ctgaaccgac gaccgggtcg aatttgcttt cgaatttctg ccattcatcc    10980

gcttattatc acttattcag gcgtagcacc aggcgtttaa gggcaccaat aactgcctta    11040

aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat taagcattct    11100

gccgacatgg aagccatcac agacggcatg atgaacctga atcgccagcg gcatcagcac    11160

cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga agttgtccat    11220

attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg agacgaaaaa    11280

catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac acgccacatc    11340

ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc agagcgatga    11400

aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat cccatatcac    11460

cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca ggcgggcaag    11520

aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct ttaaaaaggc    11580

cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact gaaatgcctc    11640

aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag tgattttttt    11700

ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag    11760

tgatcttatt tcattatggt gaaagttgga acctcttacg caaactatta actggcgaac    11820

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag    11880

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg    11940

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta    12000

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg    12060

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata    12120

tactttagat tgatttacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt    12180

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc    12240

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct    12300

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga tttgggtgat    12360

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc    12420

acgttcttta atagtggact cttgttccaa acttgaacaa cactcaaccc tatctcgggc    12480

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg    12540

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaaaggat    12600

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt    12660

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct    12720

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc    12780

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc    12840

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc    12900

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc    12960

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg    13020

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata    13080

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta    13140

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc    13200

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg    13260

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt    13320

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt    13380

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga    13440

gcgcagcgag tcagtgagcg aggaagcgac gttaat                              13476


