                         SEQUENCE LISTING

<110>  VIB VZW
       UNIVERSITEIT GENT
 
<120>  CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR BINDERS

<130>  NiCa/M6PR_Nbs/704

<150>  EP 21158298.6
<151>  2021-02-19

<150>  EP 21184788.4
<151>  2021-07-09

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Arg Tyr 
            20                  25                  30          


Trp Met Asn Trp Leu Arg Gln Ile Pro Gly Lys Glu Ile Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Gly Gly Thr Gly Thr Tyr Tyr Asp Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Thr Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Thr Tyr Tyr Arg Gly Asn Ser Ala Ile Arg Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Phe Ser Gly Arg Thr Phe Met Ser Tyr 
            20                  25                  30          


Asp Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Leu 
        35                  40                  45              


Ser Ser Ile Thr Ser Ser Ser Ser Ser Pro Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Val Ser Arg Asp Gly Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Glu Asn Trp Arg Asn Asp Trp Gln Tyr Trp Gly Gln Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  3
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH3

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Leu Asn Phe Lys Asn Phe 
            20                  25                  30          


Asp Met Ile Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Asp Ile Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Ser Ser Ser Thr Ile Trp Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Thr Ser Trp Arg Arg Pro Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH4

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ser Ile Ser Gln Gly Gly Lys Met Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ser Arg Gly Tyr Pro Met Val Arg Val Ser Glu Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH5

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ala Gly Arg Thr Phe Ser Arg Leu 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Glu Asn Gly Asp Ser Ile His Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Ala Ala Tyr Tyr Cys Ser Gly Ser Gly Cys Tyr Pro 
            100                 105                 110         


Ser Arg Ala Pro Ala Ala Ala Ser Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH6

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Ile Ser Ser Ile Gly 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Leu Asn Asn Ser Gly Met Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Gly Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Tyr Ser Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH7

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp Asn 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Ser Ser Pro Val Leu Asn Asp Ile Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH9

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Leu Ser Ile Lys 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Ser Ser Ile Pro Met Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Pro Trp Thr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  10
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH10

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Pro Ala Gly Arg Thr Phe Ser Arg Ile 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Leu Ser Tyr Tyr Ala Asp Ser Met Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Leu Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Leu Asn Asp Tyr Ile Asp Asp Tyr Val Ala Arg Asn Pro Thr 
            100                 105                 110         


Leu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  11
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH11

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Pro Thr Phe Ser Glu Ile 
            20                  25                  30          


Thr Gly Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Thr Gly Ile Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ser Thr Ser Arg Ser Ile Ala Ile Thr Val Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
aagaacaagc cgccacc                                                      17


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gctctcccta ttgtgaagtc gc                                                22


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
aagaacaagc cgccaccatg                                                   20


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
gtgcgacttc acaataggga gagc                                              24


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
gggctcttca aggcaggtgc agctgcagga gtc                                    33


<210>  17
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
gggctcttca agtctagtga tggtgatggt ggtggctgga gacggtgacc tggg             54


<210>  18
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
gatgtgcagc tgcaggagtc tggrggagg                                         29


<210>  19
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
ctagtgcggc cgctgaggag acggtgacct gggt                                   34


<210>  20
<211>  2491
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 
                485                 490                 495     


Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 
            500                 505                 510         


His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 
        515                 520                 525             


Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 
    530                 535                 540                 


Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 
545                 550                 555                 560 


Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 
                565                 570                 575     


Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 
            580                 585                 590         


Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 
        595                 600                 605             


Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 
    610                 615                 620                 


Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 
625                 630                 635                 640 


Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 
                645                 650                 655     


Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 
            660                 665                 670         


Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr 
        675                 680                 685             


Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met 
    690                 695                 700                 


Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His 
705                 710                 715                 720 


Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly 
                725                 730                 735     


Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe 
            740                 745                 750         


Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val 
        755                 760                 765             


Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala 
    770                 775                 780                 


Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser 
785                 790                 795                 800 


Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro 
                805                 810                 815     


Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met 
            820                 825                 830         


Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser 
        835                 840                 845             


Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser 
    850                 855                 860                 


Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly 
865                 870                 875                 880 


Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly 
                885                 890                 895     


Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val 
            900                 905                 910         


Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr 
        915                 920                 925             


Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val 
    930                 935                 940                 


Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly 
945                 950                 955                 960 


Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys 
                965                 970                 975     


Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln 
            980                 985                 990         


Thr Glu Glu Leu Lys Asn Trp Lys  Pro Ala Arg Pro Val  Gly Ile Glu 
        995                 1000                 1005             


Lys Ser  Leu Gln Leu Ser Thr  Glu Gly Phe Ile Thr  Leu Thr Tyr 
    1010                 1015                 1020             


Lys Gly  Pro Leu Ser Ala Lys  Gly Thr Ala Asp Ala  Phe Ile Val 
    1025                 1030                 1035             


Arg Phe  Val Cys Asn Asp Asp  Val Tyr Ser Gly Pro  Leu Lys Phe 
    1040                 1045                 1050             


Leu His  Gln Asp Ile Asp Ser  Gly Gln Gly Ile Arg  Asn Thr Tyr 
    1055                 1060                 1065             


Phe Glu  Phe Glu Thr Ala Leu  Ala Cys Val Pro Ser  Pro Val Asp 
    1070                 1075                 1080             


Cys Gln  Val Thr Asp Leu Ala  Gly Asn Glu Tyr Asp  Leu Thr Gly 
    1085                 1090                 1095             


Leu Ser  Thr Val Arg Lys Pro  Trp Thr Ala Val Asp  Thr Ser Val 
    1100                 1105                 1110             


Asp Gly  Arg Lys Arg Thr Phe  Tyr Leu Ser Val Cys  Asn Pro Leu 
    1115                 1120                 1125             


Pro Tyr  Ile Pro Gly Cys Gln  Gly Ser Ala Val Gly  Ser Cys Leu 
    1130                 1135                 1140             


Val Ser  Glu Gly Asn Ser Trp  Asn Leu Gly Val Val  Gln Met Ser 
    1145                 1150                 1155             


Pro Gln  Ala Ala Ala Asn Gly  Ser Leu Ser Ile Met  Tyr Val Asn 
    1160                 1165                 1170             


Gly Asp  Lys Cys Gly Asn Gln  Arg Phe Ser Thr Arg  Ile Thr Phe 
    1175                 1180                 1185             


Glu Cys  Ala Gln Ile Ser Gly  Ser Pro Ala Phe Gln  Leu Gln Asp 
    1190                 1195                 1200             


Gly Cys  Glu Tyr Val Phe Ile  Trp Arg Thr Val Glu  Ala Cys Pro 
    1205                 1210                 1215             


Val Val  Arg Val Glu Gly Asp  Asn Cys Glu Val Lys  Asp Pro Arg 
    1220                 1225                 1230             


His Gly  Asn Leu Tyr Asp Leu  Lys Pro Leu Gly Leu  Asn Asp Thr 
    1235                 1240                 1245             


Ile Val  Ser Ala Gly Glu Tyr  Thr Tyr Tyr Phe Arg  Val Cys Gly 
    1250                 1255                 1260             


Lys Leu  Ser Ser Asp Val Cys  Pro Thr Ser Asp Lys  Ser Lys Val 
    1265                 1270                 1275             


Val Ser  Ser Cys Gln Glu Lys  Arg Glu Pro Gln Gly  Phe His Lys 
    1280                 1285                 1290             


Val Ala  Gly Leu Leu Thr Gln  Lys Leu Thr Tyr Glu  Asn Gly Leu 
    1295                 1300                 1305             


Leu Lys  Met Asn Phe Thr Gly  Gly Asp Thr Cys His  Lys Val Tyr 
    1310                 1315                 1320             


Gln Arg  Ser Thr Ala Ile Phe  Phe Tyr Cys Asp Arg  Gly Thr Gln 
    1325                 1330                 1335             


Arg Pro  Val Phe Leu Lys Glu  Thr Ser Asp Cys Ser  Tyr Leu Phe 
    1340                 1345                 1350             


Glu Trp  Arg Thr Gln Tyr Ala  Cys Pro Pro Phe Asp  Leu Thr Glu 
    1355                 1360                 1365             


Cys Ser  Phe Lys Asp Gly Ala  Gly Asn Ser Phe Asp  Leu Ser Ser 
    1370                 1375                 1380             


Leu Ser  Arg Tyr Ser Asp Asn  Trp Glu Ala Ile Thr  Gly Thr Gly 
    1385                 1390                 1395             


Asp Pro  Glu His Tyr Leu Ile  Asn Val Cys Lys Ser  Leu Ala Pro 
    1400                 1405                 1410             


Gln Ala  Gly Thr Glu Pro Cys  Pro Pro Glu Ala Ala  Ala Cys Leu 
    1415                 1420                 1425             


Leu Gly  Gly Ser Lys Pro Val  Asn Leu Gly Arg Val  Arg Asp Gly 
    1430                 1435                 1440             


Pro Gln  Trp Arg Asp Gly Ile  Ile Val Leu Lys Tyr  Val Asp Gly 
    1445                 1450                 1455             


Asp Leu  Cys Pro Asp Gly Ile  Arg Lys Lys Ser Thr  Thr Ile Arg 
    1460                 1465                 1470             


Phe Thr  Cys Ser Glu Ser Gln  Val Asn Ser Arg Pro  Met Phe Ile 
    1475                 1480                 1485             


Ser Ala  Val Glu Asp Cys Glu  Tyr Thr Phe Ala Trp  Pro Thr Ala 
    1490                 1495                 1500             


Thr Ala  Cys Pro Met Lys Ser  Asn Glu His Asp Asp  Cys Gln Val 
    1505                 1510                 1515             


Thr Asn  Pro Ser Thr Gly His  Leu Phe Asp Leu Ser  Ser Leu Ser 
    1520                 1525                 1530             


Gly Arg  Ala Gly Phe Thr Ala  Ala Tyr Ser Glu Lys  Gly Leu Val 
    1535                 1540                 1545             


Tyr Met  Ser Ile Cys Gly Glu  Asn Glu Asn Cys Pro  Pro Gly Val 
    1550                 1555                 1560             


Gly Ala  Cys Phe Gly Gln Thr  Arg Ile Ser Val Gly  Lys Ala Asn 
    1565                 1570                 1575             


Lys Arg  Leu Arg Tyr Val Asp  Gln Val Leu Gln Leu  Val Tyr Lys 
    1580                 1585                 1590             


Asp Gly  Ser Pro Cys Pro Ser  Lys Ser Gly Leu Ser  Tyr Lys Ser 
    1595                 1600                 1605             


Val Ile  Ser Phe Val Cys Arg  Pro Glu Ala Gly Pro  Thr Asn Arg 
    1610                 1615                 1620             


Pro Met  Leu Ile Ser Leu Asp  Lys Gln Thr Cys Thr  Leu Phe Phe 
    1625                 1630                 1635             


Ser Trp  His Thr Pro Leu Ala  Cys Glu Gln Ala Thr  Glu Cys Ser 
    1640                 1645                 1650             


Val Arg  Asn Gly Ser Ser Ile  Val Asp Leu Ser Pro  Leu Ile His 
    1655                 1660                 1665             


Arg Thr  Gly Gly Tyr Glu Ala  Tyr Asp Glu Ser Glu  Asp Asp Ala 
    1670                 1675                 1680             


Ser Asp  Thr Asn Pro Asp Phe  Tyr Ile Asn Ile Cys  Gln Pro Leu 
    1685                 1690                 1695             


Asn Pro  Met His Gly Val Pro  Cys Pro Ala Gly Ala  Ala Val Cys 
    1700                 1705                 1710             


Lys Val  Pro Ile Asp Gly Pro  Pro Ile Asp Ile Gly  Arg Val Ala 
    1715                 1720                 1725             


Gly Pro  Pro Ile Leu Asn Pro  Ile Ala Asn Glu Ile  Tyr Leu Asn 
    1730                 1735                 1740             


Phe Glu  Ser Ser Thr Pro Cys  Leu Ala Asp Lys His  Phe Asn Tyr 
    1745                 1750                 1755             


Thr Ser  Leu Ile Ala Phe His  Cys Lys Arg Gly Val  Ser Met Gly 
    1760                 1765                 1770             


Thr Pro  Lys Leu Leu Arg Thr  Ser Glu Cys Asp Phe  Val Phe Glu 
    1775                 1780                 1785             


Trp Glu  Thr Pro Val Val Cys  Pro Asp Glu Val Arg  Met Asp Gly 
    1790                 1795                 1800             


Cys Thr  Leu Thr Asp Glu Gln  Leu Leu Tyr Ser Phe  Asn Leu Ser 
    1805                 1810                 1815             


Ser Leu  Ser Thr Ser Thr Phe  Lys Val Thr Arg Asp  Ser Arg Thr 
    1820                 1825                 1830             


Tyr Ser  Val Gly Val Cys Thr  Phe Ala Val Gly Pro  Glu Gln Gly 
    1835                 1840                 1845             


Gly Cys  Lys Asp Gly Gly Val  Cys Leu Leu Ser Gly  Thr Lys Gly 
    1850                 1855                 1860             


Ala Ser  Phe Gly Arg Leu Gln  Ser Met Lys Leu Asp  Tyr Arg His 
    1865                 1870                 1875             


Gln Asp  Glu Ala Val Val Leu  Ser Tyr Val Asn Gly  Asp Arg Cys 
    1880                 1885                 1890             


Pro Pro  Glu Thr Asp Asp Gly  Val Pro Cys Val Phe  Pro Phe Ile 
    1895                 1900                 1905             


Phe Asn  Gly Lys Ser Tyr Glu  Glu Cys Ile Ile Glu  Ser Arg Ala 
    1910                 1915                 1920             


Lys Leu  Trp Cys Ser Thr Thr  Ala Asp Tyr Asp Arg  Asp His Glu 
    1925                 1930                 1935             


Trp Gly  Phe Cys Arg His Ser  Asn Ser Tyr Arg Thr  Ser Ser Ile 
    1940                 1945                 1950             


Ile Phe  Lys Cys Asp Glu Asp  Glu Asp Ile Gly Arg  Pro Gln Val 
    1955                 1960                 1965             


Phe Ser  Glu Val Arg Gly Cys  Asp Val Thr Phe Glu  Trp Lys Thr 
    1970                 1975                 1980             


Lys Val  Val Cys Pro Pro Lys  Lys Leu Glu Cys Lys  Phe Val Gln 
    1985                 1990                 1995             


Lys His  Lys Thr Tyr Asp Leu  Arg Leu Leu Ser Ser  Leu Thr Gly 
    2000                 2005                 2010             


Ser Trp  Ser Leu Val His Asn  Gly Val Ser Tyr Tyr  Ile Asn Leu 
    2015                 2020                 2025             


Cys Gln  Lys Ile Tyr Lys Gly  Pro Leu Gly Cys Ser  Glu Arg Ala 
    2030                 2035                 2040             


Ser Ile  Cys Arg Arg Thr Thr  Thr Gly Asp Val Gln  Val Leu Gly 
    2045                 2050                 2055             


Leu Val  His Thr Gln Lys Leu  Gly Val Ile Gly Asp  Lys Val Val 
    2060                 2065                 2070             


Val Thr  Tyr Ser Lys Gly Tyr  Pro Cys Gly Gly Asn  Lys Thr Ala 
    2075                 2080                 2085             


Ser Ser  Val Ile Glu Leu Thr  Cys Thr Lys Thr Val  Gly Arg Pro 
    2090                 2095                 2100             


Ala Phe  Lys Arg Phe Asp Ile  Asp Ser Cys Thr Tyr  Tyr Phe Ser 
    2105                 2110                 2115             


Trp Asp  Ser Arg Ala Ala Cys  Ala Val Lys Pro Gln  Glu Val Gln 
    2120                 2125                 2130             


Met Val  Asn Gly Thr Ile Thr  Asn Pro Ile Asn Gly  Lys Ser Phe 
    2135                 2140                 2145             


Ser Leu  Gly Asp Ile Tyr Phe  Lys Leu Phe Arg Ala  Ser Gly Asp 
    2150                 2155                 2160             


Met Arg  Thr Asn Gly Asp Asn  Tyr Leu Tyr Glu Ile  Gln Leu Ser 
    2165                 2170                 2175             


Ser Ile  Thr Ser Ser Arg Asn  Pro Ala Cys Ser Gly  Ala Asn Ile 
    2180                 2185                 2190             


Cys Gln  Val Lys Pro Asn Asp  Gln His Phe Ser Arg  Lys Val Gly 
    2195                 2200                 2205             


Thr Ser  Asp Lys Thr Lys Tyr  Tyr Leu Gln Asp Gly  Asp Leu Asp 
    2210                 2215                 2220             


Val Val  Phe Ala Ser Ser Ser  Lys Cys Gly Lys Asp  Lys Thr Lys 
    2225                 2230                 2235             


Ser Val  Ser Ser Thr Ile Phe  Phe His Cys Asp Pro  Leu Val Glu 
    2240                 2245                 2250             


Asp Gly  Ile Pro Glu Phe Ser  His Glu Thr Ala Asp  Cys Gln Tyr 
    2255                 2260                 2265             


Leu Phe  Ser Trp Tyr Thr Ser  Ala Val Cys Pro Leu  Gly Val Gly 
    2270                 2275                 2280             


Phe Asp  Ser Glu Asn Pro Gly  Asp Asp Gly Gln Met  His Lys Gly 
    2285                 2290                 2295             


Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala Val Leu  Ser Leu Leu 
    2300                 2305                 2310             


Leu Val  Ala Leu Thr Cys Cys  Leu Leu Ala Leu Leu  Leu Tyr Lys 
    2315                 2320                 2325             


Lys Glu  Arg Arg Glu Thr Val  Ile Ser Lys Leu Thr  Thr Cys Cys 
    2330                 2335                 2340             


Arg Arg  Ser Ser Asn Val Ser  Tyr Lys Tyr Ser Lys  Val Asn Lys 
    2345                 2350                 2355             


Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu Trp Leu  Met Glu Glu 
    2360                 2365                 2370             


Ile Gln  Leu Pro Pro Pro Arg  Gln Gly Lys Glu Gly  Gln Glu Asn 
    2375                 2380                 2385             


Gly His  Ile Thr Thr Lys Ser  Val Lys Ala Leu Ser  Ser Leu His 
    2390                 2395                 2400             


Gly Asp  Asp Gln Asp Ser Glu  Asp Glu Val Leu Thr  Ile Pro Glu 
    2405                 2410                 2415             


Val Lys  Val His Ser Gly Arg  Gly Ala Gly Ala Glu  Ser Ser His 
    2420                 2425                 2430             


Pro Val  Arg Asn Ala Gln Ser  Asn Ala Leu Gln Glu  Arg Glu Asp 
    2435                 2440                 2445             


Asp Arg  Val Gly Leu Val Arg  Gly Glu Lys Ala Arg  Lys Gly Lys 
    2450                 2455                 2460             


Ser Ser  Ser Ala Gln Gln Lys  Thr Val Ser Ser Thr  Lys Leu Val 
    2465                 2470                 2475             


Ser Phe  His Asp Asp Ser Asp  Glu Asp Leu Leu His  Ile 
    2480                 2485                 2490     


<210>  21
<211>  2483
<212>  PRT
<213>  Mus musculus

<400>  21

Met Arg Ala Val Gln Leu Gly Pro Val Pro Ser Gly Pro Arg Val Ala 
1               5                   10                  15      


Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Gly Ser 
            20                  25                  30          


Ala Gln Ala Gln Ala Val Asp Leu Asp Ala Leu Cys Ser Tyr Thr Trp 
        35                  40                  45              


Glu Ala Val Asp Ser Lys Asn Asn Ala Val Tyr Lys Ile Asn Val Cys 
    50                  55                  60                  


Gly Asn Val Gly Ile Ser Ser Cys Gly Pro Thr Ser Ala Ile Cys Met 
65                  70                  75                  80  


Cys Asp Leu Lys Thr Glu Asn Cys Arg Ser Val Gly Asp Ser Leu Leu 
                85                  90                  95      


Arg Ser Ser Ala Arg Ser Leu Leu Glu Phe Asn Thr Thr Met Gly Cys 
            100                 105                 110         


Gln Pro Ser Asp Ser Gln His Arg Ile Gln Thr Ser Ile Thr Phe Leu 
        115                 120                 125             


Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Asp Cys 
    130                 135                 140                 


Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile 
145                 150                 155                 160 


Phe Lys Ala Asp Lys Glu Val Pro Cys Tyr Ala Phe Asp Asp Lys Leu 
                165                 170                 175     


Gln Lys His Asp Leu Asn Pro Leu Ile Lys Leu Asn Gly Gly Tyr Leu 
            180                 185                 190         


Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg 
        195                 200                 205             


Asp Ile Asp Ser Leu Arg Asp Pro Ser Thr Gln Leu Arg Val Cys Pro 
    210                 215                 220                 


Ala Gly Thr Ala Ala Cys Leu Leu Lys Gly Asn Gln Ala Phe Asp Val 
225                 230                 235                 240 


Gly Arg Pro Lys Glu Gly Leu Lys Leu Leu Ser Lys Asp Arg Leu Val 
                245                 250                 255     


Leu Thr Tyr Val Lys Glu Glu Gly Glu Lys Pro Asp Phe Cys Asn Gly 
            260                 265                 270         


His Ser Pro Ala Val Thr Val Thr Phe Val Cys Pro Ser Glu Arg Arg 
        275                 280                 285             


Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu 
    290                 295                 300                 


Val Glu Trp Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Gln Ser 
305                 310                 315                 320 


Glu Ser Cys Ser Leu Ser Ser Glu Gln His Asp Ile Thr Ile Asp Leu 
                325                 330                 335     


Ser Pro Leu Ala Gln Tyr Gly Gly Ser Pro Tyr Val Ser Asp Gly Arg 
            340                 345                 350         


Glu Tyr Thr Phe Phe Ile Asn Val Cys Gly Asp Thr Lys Val Ser Leu 
        355                 360                 365             


Cys Asn Asn Lys Glu Ala Ala Val Cys Gln Glu Lys Lys Ala Asp Ser 
    370                 375                 380                 


Thr Gln Val Lys Ile Ala Gly Arg His Gln Asn Gln Thr Leu Arg Tyr 
385                 390                 395                 400 


Ser Asp Gly Asp Leu Thr Leu Ile Tyr Ser Gly Gly Asp Glu Cys Ser 
                405                 410                 415     


Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr 
            420                 425                 430         


Ala Gly Lys Asp Gly Arg Gly Glu Pro Val Phe Thr Gly Glu Val Asp 
        435                 440                 445             


Cys Thr Tyr Phe Phe Thr Trp Asp Thr Lys Tyr Ala Cys Ile Lys Glu 
    450                 455                 460                 


Lys Glu Asp Leu Leu Cys Gly Ala Ile Asn Gly Lys Lys Arg Tyr Asp 
465                 470                 475                 480 


Leu Ser Val Leu Ala Arg His Ser Glu Ser Glu Gln Asn Trp Glu Ala 
                485                 490                 495     


Val Asp Gly Ser Gln Ala Glu Ser Glu Lys Tyr Phe Phe Ile Asn Val 
            500                 505                 510         


Cys His Arg Val Leu Gln Glu Gly Lys Ala Arg Asn Cys Pro Glu Asp 
        515                 520                 525             


Ala Ala Val Cys Ala Val Asp Lys Asn Gly Ser Lys Asn Leu Gly Lys 
    530                 535                 540                 


Phe Val Ser Ser Pro Thr Lys Glu Lys Gly His Ile Gln Leu Ser Tyr 
545                 550                 555                 560 


Thr Asp Gly Asp Asp Cys Gly Ser Asp Lys Lys Ile Ser Thr Asn Ile 
                565                 570                 575     


Thr Leu Val Cys Lys Pro Gly Asp Leu Glu Ser Ala Pro Val Leu Arg 
            580                 585                 590         


Ala Ala Arg Ser Asp Gly Cys Phe Tyr Glu Phe Glu Trp His Thr Ala 
        595                 600                 605             


Ala Ala Cys Val Leu Ser Lys Thr Glu Gly Glu Asn Cys Thr Val Leu 
    610                 615                 620                 


Asp Ala Gln Ala Gly Phe Ser Phe Asp Leu Ser Leu Leu Thr Lys Lys 
625                 630                 635                 640 


Asn Gly Ala Tyr Lys Val Glu Thr Glu Lys Tyr Asp Phe Tyr Ile Asn 
                645                 650                 655     


Val Cys Gly Pro Val Ser Met Asp Pro Cys Gln Ser Asn Ser Gly Ala 
            660                 665                 670         


Cys Gln Val Ala Lys Ser Gly Lys Ser Trp Asn Leu Gly Leu Ser Ser 
        675                 680                 685             


Thr Lys Leu Thr Tyr Tyr Asp Gly Met Ile Gln Leu Ser Tyr Arg Asn 
    690                 695                 700                 


Gly Thr Pro Tyr Asn Asn Glu Lys His Thr Pro Arg Ala Thr Leu Ile 
705                 710                 715                 720 


Thr Phe Leu Cys Asp Arg Asp Ala Gly Val Gly Phe Pro Glu Tyr Gln 
                725                 730                 735     


Glu Glu Asp Asn Ser Thr Tyr Asn Phe Arg Trp Tyr Thr Ser Tyr Ala 
            740                 745                 750         


Cys Pro Glu Glu Pro Leu Glu Cys Met Val Thr Asp Pro Ser Met Met 
        755                 760                 765             


Glu Gln Tyr Asp Leu Ser Ser Leu Val Lys Ser Glu Gly Gly Ser Gly 
    770                 775                 780                 


Gly Asn Trp Tyr Ala Met Glu Asn Ser Arg Glu His Val Thr Arg Arg 
785                 790                 795                 800 


Lys Tyr Tyr Leu Asn Val Cys Arg Pro Leu Asn Pro Val Pro Gly Cys 
                805                 810                 815     


Asp Arg Tyr Ala Ser Ala Cys Gln Met Lys Tyr Glu Asn His Glu Gly 
            820                 825                 830         


Ser Leu Ala Glu Thr Val Ser Ile Ser Asn Leu Gly Val Ala Lys Ile 
        835                 840                 845             


Gly Pro Val Val Glu Glu Ser Gly Ser Leu Leu Leu Glu Tyr Val Asn 
    850                 855                 860                 


Gly Ser Ala Cys Thr Thr Ser Asp Gly Gln Leu Thr Thr Tyr Ser Thr 
865                 870                 875                 880 


Arg Ile His Leu Val Cys Gly Arg Gly Phe Met Asn Ser His Pro Ile 
                885                 890                 895     


Phe Thr Phe Asn Trp Glu Cys Val Val Ser Phe Leu Trp Asn Thr Glu 
            900                 905                 910         


Ala Ala Cys Pro Ile Gln Thr Ile Thr Glu Thr Asp Gln Ala Cys Ser 
        915                 920                 925             


Ile Arg Asp Pro Ser Ser Gly Phe Val Phe Asn Leu Ser Pro Leu Asn 
    930                 935                 940                 


Asp Ser Ala Gln Gly His Val Val Leu Gly Ile Gly Lys Thr Phe Val 
945                 950                 955                 960 


Phe Asn Ile Cys Gly Ala Met Pro Ala Cys Gly Thr Val Ala Gly Lys 
                965                 970                 975     


Pro Ala Tyr Gly Cys Glu Ala Glu Thr Gln Ile Glu Asp Ile Lys Asp 
            980                 985                 990         


Leu Arg Pro Gln Arg Pro Val Gly  Met Glu Arg Ser Leu  Gln Leu Ser 
        995                 1000                 1005             


Ala Glu  Gly Phe Leu Thr Leu  Thr Tyr Lys Gly Ser  Ser Pro Ser 
    1010                 1015                 1020             


Asp Arg  Gly Thr Ala Phe Ile  Ile Arg Phe Ile Cys  Asn Asp Asp 
    1025                 1030                 1035             


Ile Tyr  Pro Gly Ala Pro Lys  Phe Leu His Gln Asp  Ile Asp Ser 
    1040                 1045                 1050             


Thr Arg  Gly Ile Arg Asn Thr  Tyr Phe Glu Phe Glu  Thr Ala Leu 
    1055                 1060                 1065             


Ala Cys  Thr Pro Ser Leu Val  Asp Cys Gln Val Thr  Asp Pro Ala 
    1070                 1075                 1080             


Gly Asn  Glu Tyr Asp Leu Ser  Ala Leu Ser Met Val  Arg Lys Pro 
    1085                 1090                 1095             


Trp Thr  Ala Val Asp Thr Ser  Ala Tyr Gly Lys Arg  Arg His Phe 
    1100                 1105                 1110             


Tyr Leu  Ser Val Cys Asn Pro  Leu Pro Tyr Ile Pro  Gly Cys His 
    1115                 1120                 1125             


Gly Ile  Ala Leu Gly Ser Cys  Met Val Ser Glu Asp  Asn Ser Phe 
    1130                 1135                 1140             


Asn Leu  Gly Val Val Gln Ile  Ser Pro Gln Ala Thr  Gly Asn Gly 
    1145                 1150                 1155             


Ser Leu  Ser Ile Leu Tyr Val  Asn Gly Asp Arg Cys  Gly Asp Gln 
    1160                 1165                 1170             


Arg Phe  Ser Thr Arg Ile Val  Phe Glu Cys Ala Gln  Thr Ser Gly 
    1175                 1180                 1185             


Ser Pro  Met Phe Gln Phe Val  Asn Asn Cys Glu Tyr  Val Phe Val 
    1190                 1195                 1200             


Trp Arg  Thr Val Glu Ala Cys  Pro Val Ile Arg Glu  Glu Gly Asp 
    1205                 1210                 1215             


Asn Cys  Gln Val Lys Asp Pro  Arg His Gly Asn Leu  Tyr Asp Leu 
    1220                 1225                 1230             


Lys Pro  Leu Gly Leu Asn Asp  Thr Ile Val Ser Val  Gly Glu Tyr 
    1235                 1240                 1245             


Thr Tyr  Tyr Leu Arg Val Cys  Gly Lys Leu Ser Ser  Asp Val Cys 
    1250                 1255                 1260             


Ser Ala  His Asp Gly Ser Lys  Ala Val Ser Ser Cys  Gln Glu Lys 
    1265                 1270                 1275             


Lys Gly  Pro Gln Gly Phe Gln  Lys Val Ala Gly Leu  Leu Ser Gln 
    1280                 1285                 1290             


Lys Leu  Thr Phe Glu Asn Gly  Leu Leu Lys Met Asn  Tyr Thr Gly 
    1295                 1300                 1305             


Gly Asp  Thr Cys His Lys Val  Tyr Gln Arg Ser Thr  Thr Ile Tyr 
    1310                 1315                 1320             


Phe Tyr  Cys Asp Arg Thr Thr  Gln Lys Pro Val Phe  Leu Lys Glu 
    1325                 1330                 1335             


Thr Ser  Asp Cys Ser Tyr Met  Phe Glu Trp Arg Thr  Gln Tyr Ala 
    1340                 1345                 1350             


Cys Pro  Pro Phe Asn Val Thr  Glu Cys Ser Val Gln  Asp Ala Ala 
    1355                 1360                 1365             


Gly Asn  Ser Ile Asp Leu Ser  Ser Leu Ser Arg Tyr  Ser Asp Asn 
    1370                 1375                 1380             


Trp Glu  Ala Val Thr Arg Thr  Gly Ala Thr Glu His  Tyr Leu Ile 
    1385                 1390                 1395             


Asn Val  Cys Lys Ser Leu Ser  Pro His Ala Gly Thr  Glu Pro Cys 
    1400                 1405                 1410             


Pro Pro  Glu Ala Ala Val Cys  Leu Leu Asn Gly Ser  Lys Pro Val 
    1415                 1420                 1425             


Asn Leu  Gly Lys Val Arg Asp  Gly Pro Gln Trp Thr  Asp Gly Val 
    1430                 1435                 1440             


Thr Val  Leu Gln Tyr Val Asp  Gly Asp Leu Cys Pro  Asp Lys Ile 
    1445                 1450                 1455             


Arg Arg  Arg Ser Thr Ile Ile  Arg Phe Thr Cys Ser  Asp Asn Gln 
    1460                 1465                 1470             


Val Asn  Ser Arg Pro Leu Phe  Ile Ser Ala Val Gln  Asp Cys Glu 
    1475                 1480                 1485             


Tyr Thr  Phe Ser Trp Pro Thr  Pro Ser Ala Cys Pro  Val Lys Ser 
    1490                 1495                 1500             


Asn Thr  His Asp Asp Cys Gln  Val Thr Asn Pro Ser  Thr Gly His 
    1505                 1510                 1515             


Leu Phe  Asp Leu Ser Ser Leu  Ser Gly Arg Ala Gly  Ile Asn Ala 
    1520                 1525                 1530             


Ser Tyr  Ser Glu Lys Gly Leu  Val Phe Met Ser Ile  Cys Glu Glu 
    1535                 1540                 1545             


Asn Glu  Asn Cys Gly Pro Gly  Val Gly Ala Cys Phe  Gly Gln Thr 
    1550                 1555                 1560             


Arg Ile  Ser Val Gly Lys Ala  Ser Lys Arg Leu Ser  Tyr Lys Asp 
    1565                 1570                 1575             


Gln Val  Leu Gln Leu Val Tyr  Glu Asn Gly Ser Pro  Cys Pro Ser 
    1580                 1585                 1590             


Leu Ser  Asp Leu Arg Tyr Lys  Ser Val Ile Ser Phe  Val Cys Arg 
    1595                 1600                 1605             


Pro Glu  Ala Gly Pro Thr Asn  Arg Pro Met Leu Ile  Ser Leu Asp 
    1610                 1615                 1620             


Lys Gln  Thr Cys Thr Leu Phe  Phe Ser Trp His Thr  Pro Leu Ala 
    1625                 1630                 1635             


Cys Glu  Gln Ala Thr Glu Cys  Thr Val Arg Asn Gly  Ser Ser Ile 
    1640                 1645                 1650             


Ile Asp  Leu Ser Pro Leu Ile  His Arg Thr Gly Gly  Tyr Glu Ala 
    1655                 1660                 1665             


Tyr Asp  Glu Ser Glu Asp Asp  Thr Ser Asp Thr Thr  Pro Asp Phe 
    1670                 1675                 1680             


Tyr Ile  Asn Ile Cys Gln Pro  Leu Asn Pro Met His  Gly Val Pro 
    1685                 1690                 1695             


Cys Pro  Ala Gly Ala Ser Val  Cys Lys Val Pro Val  Asp Gly Pro 
    1700                 1705                 1710             


Pro Ile  Asp Ile Gly Arg Val  Thr Gly Pro Pro Ile  Phe Asn Pro 
    1715                 1720                 1725             


Val Ala  Asn Glu Val Tyr Leu  Asn Phe Glu Ser Ser  Thr His Cys 
    1730                 1735                 1740             


Leu Ala  Asp Arg Tyr Met Asn  Tyr Thr Ser Leu Ile  Thr Phe His 
    1745                 1750                 1755             


Cys Lys  Arg Gly Val Ser Met  Gly Thr Pro Lys Leu  Ile Arg Thr 
    1760                 1765                 1770             


Asn Asp  Cys Asp Phe Val Phe  Glu Trp Glu Thr Pro  Ile Val Cys 
    1775                 1780                 1785             


Pro Asp  Glu Val Lys Thr Gln  Gly Cys Ala Val Thr  Asp Glu Gln 
    1790                 1795                 1800             


Leu Leu  Tyr Ser Phe Asn Leu  Thr Ser Leu Ser Thr  Ser Thr Phe 
    1805                 1810                 1815             


Lys Val  Thr Arg Asp Ala Arg  Thr Tyr Ser Ile Gly  Val Cys Thr 
    1820                 1825                 1830             


Ala Ala  Ala Gly Leu Gly Gln  Glu Gly Cys Lys Asp  Gly Gly Val 
    1835                 1840                 1845             


Cys Leu  Leu Ser Gly Asn Lys  Gly Ala Ser Phe Gly  Arg Leu Ala 
    1850                 1855                 1860             


Ser Met  Gln Leu Asp Tyr Arg  His Gln Asp Glu Ala  Val Ile Leu 
    1865                 1870                 1875             


Ser Tyr  Val Asn Gly Asp Pro  Cys Pro Pro Glu Thr  Asp Asp Gly 
    1880                 1885                 1890             


Glu Pro  Cys Val Phe Pro Phe  Ile Tyr Lys Gly Lys  Ser Tyr Asp 
    1895                 1900                 1905             


Glu Cys  Val Leu Glu Gly Arg  Ala Lys Leu Trp Cys  Ser Lys Thr 
    1910                 1915                 1920             


Ala Asn  Tyr Asp Arg Asp His  Glu Trp Gly Phe Cys  Arg Gln Thr 
    1925                 1930                 1935             


Asn Ser  Tyr Arg Met Ser Ala  Ile Ile Phe Thr Cys  Asp Glu Ser 
    1940                 1945                 1950             


Glu Asp  Ile Gly Arg Pro Gln  Val Phe Ser Glu Asp  Arg Gly Cys 
    1955                 1960                 1965             


Glu Val  Thr Phe Glu Trp Lys  Thr Lys Val Val Cys  Pro Pro Lys 
    1970                 1975                 1980             


Lys Met  Glu Cys Lys Phe Val  Gln Lys His Lys Thr  Tyr Asp Leu 
    1985                 1990                 1995             


Arg Leu  Leu Ser Ser Leu Thr  Gly Ser Trp Asp Phe  Val His Glu 
    2000                 2005                 2010             


Gly Asn  Ser Tyr Phe Ile Asn  Leu Cys Gln Arg Val  Tyr Lys Gly 
    2015                 2020                 2025             


Pro Leu  Asp Cys Ser Glu Arg  Ala Ser Ile Cys Lys  Lys Ser Ala 
    2030                 2035                 2040             


Thr Gly  Gln Val Gln Val Leu  Gly Leu Val His Thr  Gln Lys Leu 
    2045                 2050                 2055             


Glu Val  Ile Asp Glu Thr Val  Ile Val Thr Tyr Ser  Lys Gly Tyr 
    2060                 2065                 2070             


Pro Cys  Gly Gly Asn Lys Thr  Ala Ser Ser Val Ile  Glu Leu Thr 
    2075                 2080                 2085             


Cys Ala  Lys Thr Val Gly Arg  Pro Ala Phe Lys Arg  Phe Asp Ser 
    2090                 2095                 2100             


Val Ser  Cys Thr Tyr Tyr Phe  Tyr Trp Tyr Ser Arg  Ala Ala Cys 
    2105                 2110                 2115             


Ala Val  Arg Pro Gln Glu Val  Thr Met Val Asn Gly  Thr Leu Thr 
    2120                 2125                 2130             


Asn Pro  Val Thr Gly Lys Ser  Phe Ser Leu Gly Glu  Ile Tyr Phe 
    2135                 2140                 2145             


Lys Leu  Phe Ser Ala Ser Gly  Asp Met Arg Thr Asn  Gly Asp Asn 
    2150                 2155                 2160             


Tyr Leu  Tyr Glu Ile Gln Leu  Ser Ser Ile Thr Ser  Ser Ser Tyr 
    2165                 2170                 2175             


Pro Ala  Cys Ala Gly Ala Asn  Ile Cys Gln Val Lys  Pro Asn Asp 
    2180                 2185                 2190             


Gln His  Phe Ser Arg Lys Val  Gly Thr Ser Asp Met  Thr Lys Tyr 
    2195                 2200                 2205             


Tyr Val  Gln Asp Gly Asp Leu  Asp Val Val Phe Thr  Ser Ser Ser 
    2210                 2215                 2220             


Lys Cys  Gly Lys Asp Lys Thr  Lys Ser Val Ser Ser  Thr Ile Phe 
    2225                 2230                 2235             


Phe His  Cys Asp Pro Leu Val  Lys Asp Gly Ile Pro  Glu Phe Ser 
    2240                 2245                 2250             


His Glu  Thr Ala Asp Cys Gln  Tyr Leu Phe Ser Trp  Tyr Thr Ser 
    2255                 2260                 2265             


Ala Val  Cys Pro Leu Gly Val  Asp Phe Glu Asp Glu  Ser Ala Gly 
    2270                 2275                 2280             


Pro Glu  Tyr Lys Gly Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala 
    2285                 2290                 2295             


Val Leu  Ser Leu Leu Leu Val  Ala Leu Thr Gly Cys  Leu Leu Ala 
    2300                 2305                 2310             


Leu Leu  Leu His Lys Lys Glu  Arg Arg Glu Thr Val  Ile Asn Lys 
    2315                 2320                 2325             


Leu Thr  Ser Cys Cys Arg Arg  Ser Ser Gly Val Ser  Tyr Lys Tyr 
    2330                 2335                 2340             


Ser Lys  Val Ser Lys Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu 
    2345                 2350                 2355             


Trp Leu  Met Glu Glu Ile Gln  Val Pro Ala Pro Arg  Leu Gly Lys 
    2360                 2365                 2370             


Asp Gly  Gln Glu Asn Gly His  Ile Thr Thr Lys Ala  Val Lys Ala 
    2375                 2380                 2385             


Glu Ala  Leu Ser Ser Leu His  Gly Asp Asp Gln Asp  Ser Glu Asp 
    2390                 2395                 2400             


Glu Val  Leu Thr Val Pro Glu  Val Lys Val His Ser  Gly Arg Gly 
    2405                 2410                 2415             


Ala Glu  Val Glu Ser Ser Gln  Pro Leu Arg Asn Pro  Gln Arg Lys 
    2420                 2425                 2430             


Val Leu  Lys Glu Arg Glu Gly  Glu Arg Leu Gly Leu  Val Arg Gly 
    2435                 2440                 2445             


Glu Lys  Ala Arg Lys Gly Lys  Phe Arg Pro Gly Gln  Arg Lys Pro 
    2450                 2455                 2460             


Thr Ala  Pro Ala Lys Leu Val  Ser Phe His Asp Asp  Ser Asp Glu 
    2465                 2470                 2475             


Asp Leu  Leu His Ile 
    2480             


<210>  22
<211>  2499
<212>  PRT
<213>  Bos taurus

<400>  22

Met Glu Ala Ala Ala Gly Arg Ser Ser His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Gly Arg Pro Pro Arg Cys Pro Leu Leu Leu Gln Leu Gln Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Pro Pro Gly Trp Val Pro Gly Ala Ala Gly Thr 
        35                  40                  45              


Gln Gly Ala Glu Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
    50                  55                  60                  


Asp Thr Lys Asn Asn Met Leu Tyr Lys Ile Asn Ile Cys Gly Asn Met 
65                  70                  75                  80  


Gly Val Ala Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
                85                  90                  95      


Lys Thr Asp Ser Phe His Ser Val Gly Asp Ser Leu Leu Lys Thr Ala 
            100                 105                 110         


Ser Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Asn Cys Lys Gln Gln 
        115                 120                 125             


Asn His Lys Ile Gln Ser Ser Ile Thr Phe Leu Cys Gly Lys Thr Leu 
    130                 135                 140                 


Gly Thr Pro Glu Phe Val Thr Ala Thr Asp Cys Val His Tyr Phe Glu 
145                 150                 155                 160 


Trp Arg Thr Thr Ala Ala Cys Lys Lys Asn Ile Phe Lys Ala Asn Lys 
                165                 170                 175     


Glu Val Pro Cys Tyr Ala Phe Asp Arg Glu Leu Lys Lys His Asp Leu 
            180                 185                 190         


Asn Pro Leu Ile Lys Thr Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp 
        195                 200                 205             


Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Glu Val Leu 
    210                 215                 220                 


Arg Ala Ser Ser Pro Gln Val Arg Val Cys Pro Thr Gly Ala Ala Ala 
225                 230                 235                 240 


Cys Leu Val Arg Gly Asp Arg Ala Phe Asp Val Gly Arg Pro Gln Glu 
                245                 250                 255     


Gly Leu Lys Leu Val Ser Asn Asp Arg Leu Val Leu Ser Tyr Val Lys 
            260                 265                 270         


Glu Gly Ala Gly Gln Pro Asp Phe Cys Asp Gly His Ser Pro Ala Val 
        275                 280                 285             


Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro 
    290                 295                 300                 


Lys Leu Thr Ala Lys Ser Asn Cys Arg Phe Glu Ile Glu Trp Val Thr 
305                 310                 315                 320 


Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Arg Ser Cys Ser Leu 
                325                 330                 335     


Ser Ser Ala Gln His Asp Val Ala Val Asp Leu Gln Pro Leu Ser Arg 
            340                 345                 350         


Val Glu Ala Ser Asp Ser Leu Phe Tyr Thr Ser Glu Ala Asp Glu Tyr 
        355                 360                 365             


Thr Tyr Tyr Leu Ser Ile Cys Gly Gly Ser Gln Ala Pro Ile Cys Asn 
    370                 375                 380                 


Lys Lys Asp Ala Ala Val Cys Gln Val Lys Lys Ala Asp Ser Thr Gln 
385                 390                 395                 400 


Val Lys Val Ala Gly Arg Pro Gln Asn Leu Thr Leu Arg Tyr Ser Asp 
                405                 410                 415     


Gly Asp Leu Thr Leu Ile Tyr Phe Gly Gly Glu Glu Cys Ser Ser Gly 
            420                 425                 430         


Phe Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Gln Thr Ala Gly 
        435                 440                 445             


Asn Asn Gly Arg Gly Ala Pro Val Phe Thr Gly Glu Val Asp Cys Thr 
    450                 455                 460                 


Tyr Phe Phe Thr Trp Asp Thr Lys Tyr Ala Cys Val His Glu Lys Glu 
465                 470                 475                 480 


Ala Leu Leu Cys Gly Val Ser Asp Gly Lys Gln Arg Phe Asp Leu Ser 
                485                 490                 495     


Ala Leu Ala Arg His Ser Glu Leu Glu Gln Asn Trp Glu Ala Val Asp 
            500                 505                 510         


Gly Ser Gln Arg Glu Ala Glu Lys Lys His Phe Phe Ile Asn Ile Cys 
        515                 520                 525             


His Arg Val Leu Gln Thr Gly Gln Ala Arg Gly Cys Pro Glu Asp Ala 
    530                 535                 540                 


Ala Val Cys Ala Val Asp Lys Asn Gly Ser Lys Asn Leu Gly Arg Phe 
545                 550                 555                 560 


Ile Ser Ser Pro Thr Arg Glu Lys Gly Asn Ile Gln Leu Ser Tyr Ser 
                565                 570                 575     


Asp Gly Asp Glu Cys Gly Gly Gly Gln Lys Ile Ile Thr Asn Ile Thr 
            580                 585                 590         


Leu Met Cys Lys Pro Gly Asp Leu Glu Ser Ala Pro Val Leu Thr Thr 
        595                 600                 605             


Ser Arg Ala Asp Gly Cys Phe Tyr Glu Phe Glu Trp Arg Thr Ala Ala 
    610                 615                 620                 


Ala Cys Val Leu Ser Arg Thr Glu Gly Asp Asn Cys Thr Val Phe Asp 
625                 630                 635                 640 


Ser Gln Ala Gly Phe Ser Phe Asp Leu Thr Pro Leu Thr Lys Lys Asp 
                645                 650                 655     


Ala Tyr Lys Val Glu Thr Asp Lys Tyr Glu Phe His Ile Asn Val Cys 
            660                 665                 670         


Gly Pro Val Ser Val Gly Ala Cys Pro Pro Asp Ser Gly Ala Cys Gln 
        675                 680                 685             


Val Ser Arg Ser Asp Arg Lys Ser Trp Asn Leu Gly Arg Ser Asn Ala 
    690                 695                 700                 


Lys Leu Ser Tyr Tyr Asp Gly Met Ile Gln Leu Thr Tyr Arg Asp Gly 
705                 710                 715                 720 


Thr Pro Tyr Asn Asn Glu Lys Arg Thr Pro Arg Ala Thr Leu Ile Thr 
                725                 730                 735     


Phe Leu Cys Asp Arg Asp Ala Gly Val Gly Phe Pro Glu Tyr Gln Glu 
            740                 745                 750         


Glu Asp Asn Ser Thr Tyr Asn Phe Arg Trp Tyr Thr Ser Tyr Ala Cys 
        755                 760                 765             


Pro Glu Glu Pro Leu Glu Cys Ile Val Thr Asp Pro Val Thr Leu Asp 
    770                 775                 780                 


Gln Tyr Asp Leu Ser Arg Leu Ala Lys Ser Glu Gly Gly Pro Gly Gly 
785                 790                 795                 800 


Asn Trp Tyr Ser Leu Asp Asn Gly Gly Ala Arg Ser Thr Trp Arg Lys 
                805                 810                 815     


Tyr Tyr Ile Asn Val Cys Arg Pro Leu Asn Pro Val Pro Gly Cys Asp 
            820                 825                 830         


Arg Tyr Ala Ser Ala Cys Gln Met Lys Tyr Gln Gly Glu Gln Gly Ser 
        835                 840                 845             


Tyr Ser Glu Thr Val Ser Ile Ser Asn Leu Gly Val Ala Lys Thr Gly 
    850                 855                 860                 


Pro Met Val Glu Asp Ser Gly Ser Leu Leu Leu Glu Tyr Val Asn Gly 
865                 870                 875                 880 


Ser Ala Cys Thr Thr Ser Asp Gln Arg Arg Thr Thr Tyr Thr Thr Arg 
                885                 890                 895     


Ile His Leu Val Cys Ser Thr Gly Ser Leu Tyr Thr His Pro Ile Phe 
            900                 905                 910         


Ser Leu Asn Trp Glu Cys Val Val Ser Phe Leu Trp Asn Thr Ala Ala 
        915                 920                 925             


Ala Cys Pro Ile Arg Ile Thr Thr Asp Ile Asp Gln Val Cys Ser Ile 
    930                 935                 940                 


Lys Asp Pro Asn Ser Gly Tyr Val Phe Asp Leu Asn Pro Leu Asn Asn 
945                 950                 955                 960 


Ser Arg Gly Tyr Val Val Leu Gly Ile Gly Lys Thr Phe Leu Phe Asn 
                965                 970                 975     


Val Cys Gly Asp Met Pro Ala Cys Gly Thr Leu Asp Gly Lys Pro Ala 
            980                 985                 990         


Ser Gly Cys Glu Ala Glu Val Gln  Met Asp Asp Met Lys  Thr Leu Lys 
        995                 1000                 1005             


Pro Gly  Arg Leu Val Gly Leu  Glu Lys Ser Leu Gln  Leu Ser Thr 
    1010                 1015                 1020             


Glu Gly  Phe Ile Thr Leu Asn  Tyr Thr Gly Leu Pro  Ser His Pro 
    1025                 1030                 1035             


Asn Gly  Arg Ala Asp Ala Phe  Ile Ile Arg Phe Val  Cys Asn Asp 
    1040                 1045                 1050             


Asp Val  Tyr Pro Gly Thr Pro  Lys Phe Leu His Gln  Asp Ile Asp 
    1055                 1060                 1065             


Ser Ser  Leu Gly Ile Arg Asp  Thr Phe Phe Glu Phe  Glu Thr Ala 
    1070                 1075                 1080             


Leu Ala  Cys Val Pro Ser Pro  Val Asp Cys Gln Val  Thr Asp Pro 
    1085                 1090                 1095             


Ala Gly  Asn Glu Tyr Asp Leu  Ser Gly Leu Ser Lys  Ala Arg Lys 
    1100                 1105                 1110             


Pro Trp  Thr Ala Val Asp Thr  Phe Asp Glu Gly Lys  Lys Arg Thr 
    1115                 1120                 1125             


Phe Tyr  Leu Ser Val Cys Thr  Pro Leu Pro Tyr Ile  Pro Gly Cys 
    1130                 1135                 1140             


His Gly  Thr Ala Val Gly Cys  Cys Leu Val Thr Glu  Asp Ser Lys 
    1145                 1150                 1155             


Leu Asn  Leu Gly Val Val Gln  Ile Ser Pro Gln Val  Gly Ala Asn 
    1160                 1165                 1170             


Gly Ser  Leu Ser Leu Val Tyr  Val Asn Gly Asp Lys  Cys Lys Asn 
    1175                 1180                 1185             


Gln Arg  Phe Ser Thr Arg Ile  Asn Leu Glu Cys Ala  His Thr Thr 
    1190                 1195                 1200             


Gly Ser  Pro Thr Phe Gln Leu  Gln Asn Asp Cys Glu  Tyr Val Phe 
    1205                 1210                 1215             


Leu Trp  Arg Thr Val Glu Ala  Cys Pro Val Val Arg  Ala Glu Gly 
    1220                 1225                 1230             


Asp Tyr  Cys Glu Val Arg Asp  Pro Arg His Gly Asn  Leu Tyr Asn 
    1235                 1240                 1245             


Leu Ile  Pro Leu Gly Leu Asn  Asp Thr Val Val Arg  Ala Gly Glu 
    1250                 1255                 1260             


Tyr Thr  Tyr Tyr Phe Arg Val  Cys Gly Glu Leu Thr  Ser Gly Val 
    1265                 1270                 1275             


Cys Pro  Thr Ser Asp Lys Ser  Lys Val Ile Ser Ser  Cys Gln Glu 
    1280                 1285                 1290             


Lys Arg  Gly Pro Gln Gly Phe  Gln Lys Val Ala Gly  Leu Phe Asn 
    1295                 1300                 1305             


Gln Lys  Leu Thr Tyr Glu Asn  Gly Val Leu Lys Met  Asn Tyr Thr 
    1310                 1315                 1320             


Gly Gly  Asp Thr Cys His Lys  Val Tyr Gln Arg Ser  Thr Thr Ile 
    1325                 1330                 1335             


Phe Phe  Tyr Cys Asp Arg Ser  Thr Gln Ala Pro Val  Phe Leu Gln 
    1340                 1345                 1350             


Glu Thr  Ser Asp Cys Ser Tyr  Leu Phe Glu Trp Arg  Thr Gln Tyr 
    1355                 1360                 1365             


Ala Cys  Pro Pro Tyr Asp Leu  Thr Glu Cys Ser Phe  Lys Asn Glu 
    1370                 1375                 1380             


Ala Gly  Glu Thr Tyr Asp Leu  Ser Ser Leu Ser Arg  Tyr Ser Asp 
    1385                 1390                 1395             


Asn Trp  Glu Ala Val Thr Gly  Thr Gly Ser Thr Glu  His Tyr Leu 
    1400                 1405                 1410             


Ile Asn  Val Cys Lys Ser Leu  Ser Pro Gln Ala Gly  Ser Asp Pro 
    1415                 1420                 1425             


Cys Pro  Pro Glu Ala Ala Val  Cys Leu Leu Gly Gly  Pro Lys Pro 
    1430                 1435                 1440             


Val Asn  Leu Gly Arg Val Arg  Asp Ser Pro Gln Trp  Ser Gln Gly 
    1445                 1450                 1455             


Leu Thr  Leu Leu Lys Tyr Val  Asp Gly Asp Leu Cys  Pro Asp Gln 
    1460                 1465                 1470             


Ile Arg  Lys Lys Ser Thr Thr  Ile Arg Phe Thr Cys  Ser Glu Ser 
    1475                 1480                 1485             


His Val  Asn Ser Arg Pro Met  Phe Ile Ser Ala Val  Glu Asp Cys 
    1490                 1495                 1500             


Glu Tyr  Thr Phe Ser Trp Pro  Thr Ala Ala Ala Cys  Ala Val Lys 
    1505                 1510                 1515             


Ser Asn  Val His Asp Asp Cys  Gln Val Thr Asn Pro  Ala Thr Gly 
    1520                 1525                 1530             


His Leu  Phe Asp Leu Ser Ser  Leu Ser Gly Arg Ala  Gly Phe Thr 
    1535                 1540                 1545             


Ala Ala  Tyr Ser Glu Lys Gly  Leu Val Tyr Leu Ser  Val Cys Gly 
    1550                 1555                 1560             


Asp Asn  Glu Asn Cys Ala Asn  Gly Val Gly Ala Cys  Phe Gly Gln 
    1565                 1570                 1575             


Thr Arg  Ile Ser Val Gly Lys  Ala Ser Lys Arg Leu  Thr Tyr Val 
    1580                 1585                 1590             


Asp Gln  Val Leu Gln Leu Val  Tyr Glu Gly Gly Ser  Pro Cys Pro 
    1595                 1600                 1605             


Ser Lys  Thr Gly Leu Ser Tyr  Lys Ser Val Ile Ser  Phe Val Cys 
    1610                 1615                 1620             


Arg Pro  Glu Val Gly Pro Thr  Asn Arg Pro Met Leu  Ile Ser Leu 
    1625                 1630                 1635             


Asp Lys  Arg Thr Cys Thr Leu  Phe Phe Ser Trp His  Thr Pro Leu 
    1640                 1645                 1650             


Ala Cys  Glu Gln Thr Thr Glu  Cys Ser Val Arg Asn  Gly Ser Ser 
    1655                 1660                 1665             


Leu Ile  Asp Leu Ser Pro Leu  Ile His Arg Thr Gly  Gly Tyr Glu 
    1670                 1675                 1680             


Ala Tyr  Asp Glu Ser Glu Asp  Asp Gly Ser Asp Thr  Ser Pro Asp 
    1685                 1690                 1695             


Phe Tyr  Ile Asn Ile Cys Gln  Pro Leu Asn Pro Met  His Gly Leu 
    1700                 1705                 1710             


Ala Cys  Pro Ala Gly Thr Ala  Val Cys Lys Val Pro  Val Asp Gly 
    1715                 1720                 1725             


Pro Pro  Ile Asp Ile Gly Arg  Val Ala Gly Pro Pro  Ile Leu Asn 
    1730                 1735                 1740             


Pro Ile  Ala Asn Glu Val Tyr  Leu Asn Phe Glu Ser  Ser Thr Pro 
    1745                 1750                 1755             


Cys Leu  Ala Asp Arg His Phe  Asn Tyr Thr Ser Leu  Ile Thr Phe 
    1760                 1765                 1770             


His Cys  Lys Arg Gly Val Ser  Met Gly Thr Pro Lys  Leu Leu Arg 
    1775                 1780                 1785             


Thr Ser  Val Cys Asp Phe Val  Phe Glu Trp Glu Thr  Pro Leu Val 
    1790                 1795                 1800             


Cys Pro  Asp Glu Val Lys Thr  Asp Gly Cys Ser Leu  Thr Asp Glu 
    1805                 1810                 1815             


Gln Leu  Tyr Tyr Ser Phe Asn  Leu Ser Ser Leu Ser  Lys Ser Thr 
    1820                 1825                 1830             


Phe Lys  Val Thr Arg Gly Pro  His Thr Tyr Ser Val  Gly Val Cys 
    1835                 1840                 1845             


Thr Ala  Ala Ala Gly Leu Asp  Glu Gly Gly Cys Lys  Asp Gly Ala 
    1850                 1855                 1860             


Val Cys  Leu Leu Ser Gly Ser  Lys Gly Ala Ser Phe  Gly Arg Leu 
    1865                 1870                 1875             


Ala Ser  Met Lys Leu Asp Tyr  Arg His Gln Asp Glu  Ala Val Ile 
    1880                 1885                 1890             


Leu Ser  Tyr Ala Asn Gly Asp  Thr Cys Pro Pro Glu  Thr Glu Asp 
    1895                 1900                 1905             


Gly Glu  Pro Cys Val Phe Pro  Phe Val Phe Asn Gly  Lys Ser Tyr 
    1910                 1915                 1920             


Glu Glu  Cys Val Val Glu Ser  Arg Ala Arg Leu Trp  Cys Ala Thr 
    1925                 1930                 1935             


Thr Ala  Asn Tyr Asp Arg Asp  His Glu Trp Gly Phe  Cys Lys His 
    1940                 1945                 1950             


Ser Thr  Ser His Arg Thr Ser  Val Ile Ile Phe Lys  Cys Asp Glu 
    1955                 1960                 1965             


Asp Ala  Asp Val Gly Arg Pro  Gln Val Phe Ser Glu  Val Arg Gly 
    1970                 1975                 1980             


Cys Glu  Val Thr Phe Glu Trp  Lys Thr Lys Val Val  Cys Pro Pro 
    1985                 1990                 1995             


Lys Lys  Met Glu Cys Lys Phe  Val Gln Lys His Arg  Thr Tyr Asp 
    2000                 2005                 2010             


Leu Arg  Leu Leu Ser Ser Leu  Thr Gly Ser Trp Ser  Phe Val His 
    2015                 2020                 2025             


Asn Gly  Ala Ser Tyr Tyr Ile  Asn Leu Cys Gln Lys  Ile Tyr Lys 
    2030                 2035                 2040             


Gly Pro  Gln Asp Cys Ser Glu  Arg Ala Ser Val Cys  Lys Lys Ser 
    2045                 2050                 2055             


Thr Ser  Gly Glu Val Gln Val  Leu Gly Leu Val His  Thr Gln Lys 
    2060                 2065                 2070             


Leu Asp  Val Val Asp Asp Arg  Val Ile Val Thr Tyr  Ser Lys Gly 
    2075                 2080                 2085             


His Tyr  Cys Gly Asp Asn Lys  Thr Ala Ser Ala Val  Ile Glu Leu 
    2090                 2095                 2100             


Thr Cys  Ala Lys Thr Val Gly  Arg Pro Ser Phe Thr  Arg Phe Asp 
    2105                 2110                 2115             


Val Asp  Ser Cys Thr Tyr His  Phe Ser Trp Asp Ser  Arg Ala Ala 
    2120                 2125                 2130             


Cys Ala  Val Lys Pro Gln Glu  Val Gln Met Val Asn  Gly Thr Ile 
    2135                 2140                 2145             


Thr Asn  Pro Ala Asn Gly Arg  Ser Phe Ser Leu Gly  Asp Ile Tyr 
    2150                 2155                 2160             


Phe Lys  Arg Phe Ser Ala Ser  Gly Asp Val Arg Thr  Asn Gly Asp 
    2165                 2170                 2175             


Arg Tyr  Ile Tyr Glu Ile Gln  Leu Ser Ser Ile Thr  Gly Ser Ser 
    2180                 2185                 2190             


Ser Pro  Ala Cys Ser Gly Ala  Ser Ile Cys Gln Arg  Lys Ala Asn 
    2195                 2200                 2205             


Asp Gln  His Phe Ser Arg Lys  Val Gly Thr Ser Asn  Gln Thr Arg 
    2210                 2215                 2220             


Tyr Tyr  Val Gln Asp Gly Asp  Leu Asp Val Val Phe  Thr Ser Ser 
    2225                 2230                 2235             


Ser Lys  Cys Gly Lys Asp Lys  Thr Lys Ser Val Ser  Ser Thr Ile 
    2240                 2245                 2250             


Phe Phe  His Cys Asp Pro Leu  Val Lys Asp Gly Ile  Pro Glu Phe 
    2255                 2260                 2265             


Ser His  Glu Thr Ala Asp Cys  Gln Tyr Leu Phe Ser  Trp His Thr 
    2270                 2275                 2280             


Ser Ala  Val Cys Pro Leu Gly  Ala Gly Phe Asp Glu  Glu Ile Ala 
    2285                 2290                 2295             


Gly Asp  Asp Ala Gln Glu His  Lys Gly Leu Ser Glu  Arg Ser Gln 
    2300                 2305                 2310             


Ala Val  Gly Ala Val Leu Ser  Leu Leu Leu Val Ala  Leu Thr Ala 
    2315                 2320                 2325             


Cys Leu  Leu Thr Leu Leu Leu  Tyr Lys Lys Glu Arg  Arg Glu Met 
    2330                 2335                 2340             


Val Met  Ser Arg Leu Thr Asn  Cys Cys Arg Arg Ser  Ala Asn Val 
    2345                 2350                 2355             


Ser Tyr  Lys Tyr Ser Lys Val  Asn Lys Glu Glu Glu  Ala Asp Glu 
    2360                 2365                 2370             


Asn Glu  Thr Glu Trp Leu Met  Glu Glu Ile Gln Pro  Pro Ala Pro 
    2375                 2380                 2385             


Arg Pro  Gly Lys Glu Gly Gln  Glu Asn Gly His Val  Ala Ala Lys 
    2390                 2395                 2400             


Ser Val  Arg Ala Ala Asp Thr  Leu Ser Ala Leu His  Gly Asp Glu 
    2405                 2410                 2415             


Gln Asp  Ser Glu Asp Glu Val  Leu Thr Leu Pro Glu  Val Lys Val 
    2420                 2425                 2430             


Arg Pro  Pro Gly Arg Ala Pro  Gly Ala Glu Gly Gly  Pro Pro Leu 
    2435                 2440                 2445             


Arg Pro  Leu Pro Arg Lys Ala  Pro Pro Pro Leu Arg  Ala Asp Asp 
    2450                 2455                 2460             


Arg Val  Gly Leu Val Arg Gly  Glu Pro Ala Arg Arg  Gly Arg Pro 
    2465                 2470                 2475             


Arg Ala  Ala Ala Thr Pro Ile  Ser Thr Phe His Asp  Asp Ser Asp 
    2480                 2485                 2490             


Glu Asp  Leu Leu His Val 
    2495                 


<210>  23
<211>  476
<212>  PRT
<213>  Bos taurus

<400>  23

Met Glu Ala Ala Ala Gly Arg Ser Ser His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Gly Arg Pro Pro Arg Cys Pro Leu Leu Leu Gln Leu Gln Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Pro Pro Gly Trp Val Pro Gly Ala Ala Gly Thr 
        35                  40                  45              


Gln Gly Ala Glu Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
    50                  55                  60                  


Asp Thr Lys Asn Asn Met Leu Tyr Lys Ile Asn Ile Cys Gly Asn Met 
65                  70                  75                  80  


Gly Val Ala Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
                85                  90                  95      


Lys Thr Asp Ser Phe His Ser Val Gly Asp Ser Leu Leu Lys Thr Ala 
            100                 105                 110         


Ser Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Asn Cys Lys Gln Gln 
        115                 120                 125             


Asn His Lys Ile Gln Ser Ser Ile Thr Phe Leu Cys Gly Lys Thr Leu 
    130                 135                 140                 


Gly Thr Pro Glu Phe Val Thr Ala Thr Asp Cys Val His Tyr Phe Glu 
145                 150                 155                 160 


Trp Arg Thr Thr Ala Ala Cys Lys Lys Asn Ile Phe Lys Ala Asn Lys 
                165                 170                 175     


Glu Val Pro Cys Tyr Ala Phe Asp Arg Glu Leu Lys Lys His Asp Leu 
            180                 185                 190         


Asn Pro Leu Ile Lys Thr Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp 
        195                 200                 205             


Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Glu Val Leu 
    210                 215                 220                 


Arg Ala Ser Ser Pro Gln Val Arg Val Cys Pro Thr Gly Ala Ala Ala 
225                 230                 235                 240 


Cys Leu Val Arg Gly Asp Arg Ala Phe Asp Val Gly Arg Pro Gln Glu 
                245                 250                 255     


Gly Leu Lys Leu Val Ser Asn Asp Arg Leu Val Leu Ser Tyr Val Lys 
            260                 265                 270         


Glu Gly Ala Gly Gln Pro Asp Phe Cys Asp Gly His Ser Pro Ala Val 
        275                 280                 285             


Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro 
    290                 295                 300                 


Lys Leu Thr Ala Lys Ser Asn Cys Arg Phe Glu Ile Glu Trp Val Thr 
305                 310                 315                 320 


Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Arg Ser Cys Ser Leu 
                325                 330                 335     


Ser Ser Ala Gln His Asp Val Ala Val Asp Leu Gln Pro Leu Ser Arg 
            340                 345                 350         


Val Glu Ala Ser Asp Ser Leu Phe Tyr Thr Ser Glu Ala Asp Glu Tyr 
        355                 360                 365             


Thr Tyr Tyr Leu Ser Ile Cys Gly Gly Ser Gln Ala Pro Ile Cys Asn 
    370                 375                 380                 


Lys Lys Asp Ala Ala Val Cys Gln Val Lys Lys Ala Asp Ser Thr Gln 
385                 390                 395                 400 


Val Lys Val Ala Gly Arg Pro Gln Asn Leu Thr Leu Arg Tyr Ser Asp 
                405                 410                 415     


Gly Asp Leu Thr Leu Ile Tyr Phe Gly Gly Glu Glu Cys Ser Ser Gly 
            420                 425                 430         


Phe Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Gln Thr Ala Gly 
        435                 440                 445             


Asn Asn Gly Arg Gly Ala Pro Val Phe Thr Gly Glu Val Asp Cys Thr 
    450                 455                 460                 


Tyr Phe Phe Thr Trp Asp Thr Lys Tyr Ala Cys Val 
465                 470                 475     


<210>  24
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val 
465         


<210>  25
<211>  462
<212>  PRT
<213>  Mus musculus

<400>  25

Met Arg Ala Val Gln Leu Gly Pro Val Pro Ser Gly Pro Arg Val Ala 
1               5                   10                  15      


Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Gly Ser 
            20                  25                  30          


Ala Gln Ala Gln Ala Val Asp Leu Asp Ala Leu Cys Ser Tyr Thr Trp 
        35                  40                  45              


Glu Ala Val Asp Ser Lys Asn Asn Ala Val Tyr Lys Ile Asn Val Cys 
    50                  55                  60                  


Gly Asn Val Gly Ile Ser Ser Cys Gly Pro Thr Ser Ala Ile Cys Met 
65                  70                  75                  80  


Cys Asp Leu Lys Thr Glu Asn Cys Arg Ser Val Gly Asp Ser Leu Leu 
                85                  90                  95      


Arg Ser Ser Ala Arg Ser Leu Leu Glu Phe Asn Thr Thr Met Gly Cys 
            100                 105                 110         


Gln Pro Ser Asp Ser Gln His Arg Ile Gln Thr Ser Ile Thr Phe Leu 
        115                 120                 125             


Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Asp Cys 
    130                 135                 140                 


Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile 
145                 150                 155                 160 


Phe Lys Ala Asp Lys Glu Val Pro Cys Tyr Ala Phe Asp Asp Lys Leu 
                165                 170                 175     


Gln Lys His Asp Leu Asn Pro Leu Ile Lys Leu Asn Gly Gly Tyr Leu 
            180                 185                 190         


Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg 
        195                 200                 205             


Asp Ile Asp Ser Leu Arg Asp Pro Ser Thr Gln Leu Arg Val Cys Pro 
    210                 215                 220                 


Ala Gly Thr Ala Ala Cys Leu Leu Lys Gly Asn Gln Ala Phe Asp Val 
225                 230                 235                 240 


Gly Arg Pro Lys Glu Gly Leu Lys Leu Leu Ser Lys Asp Arg Leu Val 
                245                 250                 255     


Leu Thr Tyr Val Lys Glu Glu Gly Glu Lys Pro Asp Phe Cys Asn Gly 
            260                 265                 270         


His Ser Pro Ala Val Thr Val Thr Phe Val Cys Pro Ser Glu Arg Arg 
        275                 280                 285             


Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu 
    290                 295                 300                 


Val Glu Trp Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Gln Ser 
305                 310                 315                 320 


Glu Ser Cys Ser Leu Ser Ser Glu Gln His Asp Ile Thr Ile Asp Leu 
                325                 330                 335     


Ser Pro Leu Ala Gln Tyr Gly Gly Ser Pro Tyr Val Ser Asp Gly Arg 
            340                 345                 350         


Glu Tyr Thr Phe Phe Ile Asn Val Cys Gly Asp Thr Lys Val Ser Leu 
        355                 360                 365             


Cys Asn Asn Lys Glu Ala Ala Val Cys Gln Glu Lys Lys Ala Asp Ser 
    370                 375                 380                 


Thr Gln Val Lys Ile Ala Gly Arg His Gln Asn Gln Thr Leu Arg Tyr 
385                 390                 395                 400 


Ser Asp Gly Asp Leu Thr Leu Ile Tyr Ser Gly Gly Asp Glu Cys Ser 
                405                 410                 415     


Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr 
            420                 425                 430         


Ala Gly Lys Asp Gly Arg Gly Glu Pro Val Phe Thr Gly Glu Val Asp 
        435                 440                 445             


Cys Thr Tyr Phe Phe Thr Trp Asp Thr Lys Tyr Ala Cys Ile 
    450                 455                 460         


<210>  26
<211>  1094
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human acid alfa-glucosidase (hGAA) fused to CI-M6PR-VHH1 amino 
       acid sequence (hGAA-G4S(3)-VHH1)

<400>  26

Met Gly Ser Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu 
1               5                   10                  15      


Ala Val Cys Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His 
            20                  25                  30          


Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser 
        35                  40                  45              


Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser 
    50                  55                  60                  


Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala 
65                  70                  75                  80  


Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala 
                85                  90                  95      


Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys 
            100                 105                 110         


Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro 
        115                 120                 125             


Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu 
    130                 135                 140                 


Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro 
145                 150                 155                 160 


Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met 
                165                 170                 175     


Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg 
            180                 185                 190         


Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro 
        195                 200                 205             


Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile 
    210                 215                 220                 


Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala 
225                 230                 235                 240 


Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro 
                245                 250                 255     


Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu 
            260                 265                 270         


Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro 
        275                 280                 285             


Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu 
    290                 295                 300                 


Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala 
305                 310                 315                 320 


Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr 
                325                 330                 335     


Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser 
            340                 345                 350         


Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro 
        355                 360                 365             


Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr 
    370                 375                 380                 


Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro 
385                 390                 395                 400 


Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp 
                405                 410                 415     


Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln 
            420                 425                 430         


Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala 
        435                 440                 445             


Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly 
    450                 455                 460                 


Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile 
465                 470                 475                 480 


Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro 
                485                 490                 495     


Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln 
            500                 505                 510         


Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe 
        515                 520                 525             


Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro 
    530                 535                 540                 


Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile 
545                 550                 555                 560 


Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn 
                565                 570                 575     


Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys 
            580                 585                 590         


Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly 
        595                 600                 605             


His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp 
    610                 615                 620                 


Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu 
625                 630                 635                 640 


Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr 
                645                 650                 655     


Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro 
            660                 665                 670         


Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr 
        675                 680                 685             


Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu 
    690                 695                 700                 


Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His 
705                 710                 715                 720 


Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys 
                725                 730                 735     


Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala 
            740                 745                 750         


Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly 
        755                 760                 765             


Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu 
    770                 775                 780                 


Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala 
785                 790                 795                 800 


Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr 
                805                 810                 815     


Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro 
            820                 825                 830         


Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val 
        835                 840                 845             


Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp 
    850                 855                 860                 


Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile 
865                 870                 875                 880 


Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr 
                885                 890                 895     


Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val 
            900                 905                 910         


Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn 
        915                 920                 925             


Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu 
    930                 935                 940                 


Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Leu Gln Val 
                965                 970                 975     


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            980                 985                 990         


Arg Leu Ser Cys Val Ala Ser Gly  Phe Thr Phe Asp Arg  Tyr Trp Met 
        995                 1000                 1005             


Asn Trp  Leu Arg Gln Ile Pro  Gly Lys Glu Ile Glu  Trp Val Ser 
    1010                 1015                 1020             


Thr Ile  Asn Thr Gly Gly Thr  Gly Thr Tyr Tyr Asp  Asp Ser Val 
    1025                 1030                 1035             


Lys Gly  Arg Phe Ser Ile Ser  Arg Asp Asp Ala Lys  Asn Thr Leu 
    1040                 1045                 1050             


Tyr Leu  Thr Met Asn Ser Leu  Lys Thr Glu Asp Thr  Ala Val Tyr 
    1055                 1060                 1065             


Tyr Cys  Ala Arg Gly Ala Thr  Tyr Tyr Arg Gly Asn  Ser Ala Ile 
    1070                 1075                 1080             


Arg Gly  Gln Gly Thr Gln Val  Thr Val Ser Ser 
    1085                 1090                 


<210>  27
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human acid alfa-glucosidase (hGAA) fused to CI-M6PR-VHH5 amino 
       acid sequence (hGAA-G4S(3)-VHH5)

<400>  27

Met Gly Ser Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu 
1               5                   10                  15      


Ala Val Cys Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His 
            20                  25                  30          


Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser 
        35                  40                  45              


Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser 
    50                  55                  60                  


Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala 
65                  70                  75                  80  


Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala 
                85                  90                  95      


Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys 
            100                 105                 110         


Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro 
        115                 120                 125             


Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu 
    130                 135                 140                 


Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro 
145                 150                 155                 160 


Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met 
                165                 170                 175     


Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg 
            180                 185                 190         


Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro 
        195                 200                 205             


Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile 
    210                 215                 220                 


Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala 
225                 230                 235                 240 


Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro 
                245                 250                 255     


Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu 
            260                 265                 270         


Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro 
        275                 280                 285             


Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu 
    290                 295                 300                 


Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala 
305                 310                 315                 320 


Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr 
                325                 330                 335     


Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser 
            340                 345                 350         


Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro 
        355                 360                 365             


Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr 
    370                 375                 380                 


Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro 
385                 390                 395                 400 


Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp 
                405                 410                 415     


Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln 
            420                 425                 430         


Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala 
        435                 440                 445             


Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly 
    450                 455                 460                 


Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile 
465                 470                 475                 480 


Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro 
                485                 490                 495     


Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln 
            500                 505                 510         


Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe 
        515                 520                 525             


Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro 
    530                 535                 540                 


Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile 
545                 550                 555                 560 


Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn 
                565                 570                 575     


Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys 
            580                 585                 590         


Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly 
        595                 600                 605             


His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp 
    610                 615                 620                 


Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu 
625                 630                 635                 640 


Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr 
                645                 650                 655     


Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro 
            660                 665                 670         


Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr 
        675                 680                 685             


Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu 
    690                 695                 700                 


Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His 
705                 710                 715                 720 


Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys 
                725                 730                 735     


Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala 
            740                 745                 750         


Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly 
        755                 760                 765             


Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu 
    770                 775                 780                 


Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala 
785                 790                 795                 800 


Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr 
                805                 810                 815     


Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro 
            820                 825                 830         


Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val 
        835                 840                 845             


Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp 
    850                 855                 860                 


Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile 
865                 870                 875                 880 


Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr 
                885                 890                 895     


Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val 
            900                 905                 910         


Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn 
        915                 920                 925             


Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu 
    930                 935                 940                 


Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Leu Gln Val 
                965                 970                 975     


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
            980                 985                 990         


Lys Leu Ser Cys Ala Ala Ala Gly  Arg Thr Phe Ser Arg  Leu Ala Met 
        995                 1000                 1005             


Gly Trp  Phe Arg Gln Ala Pro  Gly Lys Glu Arg Glu  Phe Val Ala 
    1010                 1015                 1020             


Ala Ile  Ser Glu Asn Gly Asp  Ser Ile His Tyr Ser  Asp Ser Val 
    1025                 1030                 1035             


Lys Gly  Arg Phe Ala Val Ser  Arg Asp Asn Ala Lys  Asn Thr Val 
    1040                 1045                 1050             


Tyr Leu  Gln Met Asn Ser Leu  Lys Pro Glu Asp Thr  Ala Ile Tyr 
    1055                 1060                 1065             


Tyr Cys  Ala Ala Asp Arg Ala  Ala Tyr Tyr Cys Ser  Gly Ser Gly 
    1070                 1075                 1080             


Cys Tyr  Pro Ser Arg Ala Pro  Ala Ala Ala Ser Tyr  Asp Tyr Trp 
    1085                 1090                 1095             


Gly Gln  Gly Thr Gln Val Thr  Val Ser Ser 
    1100                 1105             


<210>  28
<211>  1090
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human acid alfa-glucosidase (hGAA) fused to CI-M6PR-VHH7 amino 
       acid sequence (hGAA-G4S(3)-VHH7)

<400>  28

Met Gly Ser Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu 
1               5                   10                  15      


Ala Val Cys Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His 
            20                  25                  30          


Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser 
        35                  40                  45              


Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser 
    50                  55                  60                  


Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala 
65                  70                  75                  80  


Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala 
                85                  90                  95      


Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys 
            100                 105                 110         


Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro 
        115                 120                 125             


Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu 
    130                 135                 140                 


Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro 
145                 150                 155                 160 


Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met 
                165                 170                 175     


Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg 
            180                 185                 190         


Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro 
        195                 200                 205             


Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile 
    210                 215                 220                 


Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala 
225                 230                 235                 240 


Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro 
                245                 250                 255     


Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu 
            260                 265                 270         


Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro 
        275                 280                 285             


Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu 
    290                 295                 300                 


Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala 
305                 310                 315                 320 


Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr 
                325                 330                 335     


Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser 
            340                 345                 350         


Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro 
        355                 360                 365             


Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr 
    370                 375                 380                 


Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro 
385                 390                 395                 400 


Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp 
                405                 410                 415     


Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln 
            420                 425                 430         


Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala 
        435                 440                 445             


Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly 
    450                 455                 460                 


Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile 
465                 470                 475                 480 


Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro 
                485                 490                 495     


Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln 
            500                 505                 510         


Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe 
        515                 520                 525             


Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro 
    530                 535                 540                 


Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile 
545                 550                 555                 560 


Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn 
                565                 570                 575     


Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys 
            580                 585                 590         


Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly 
        595                 600                 605             


His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp 
    610                 615                 620                 


Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu 
625                 630                 635                 640 


Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr 
                645                 650                 655     


Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro 
            660                 665                 670         


Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr 
        675                 680                 685             


Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu 
    690                 695                 700                 


Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His 
705                 710                 715                 720 


Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys 
                725                 730                 735     


Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala 
            740                 745                 750         


Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly 
        755                 760                 765             


Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu 
    770                 775                 780                 


Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala 
785                 790                 795                 800 


Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr 
                805                 810                 815     


Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro 
            820                 825                 830         


Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val 
        835                 840                 845             


Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp 
    850                 855                 860                 


Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile 
865                 870                 875                 880 


Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr 
                885                 890                 895     


Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val 
            900                 905                 910         


Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn 
        915                 920                 925             


Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu 
    930                 935                 940                 


Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Leu Gln Val 
                965                 970                 975     


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            980                 985                 990         


Arg Leu Ser Cys Ala Ala Ser Gly  Ile Ile Phe Ser Asp  Asn Arg Met 
        995                 1000                 1005             


Asp Trp  Tyr Arg Gln Ala Pro  Gly Lys Gln Arg Glu  Trp Val Ala 
    1010                 1015                 1020             


Thr Leu  Ala Ser Tyr Gly Trp  Lys Thr Tyr Ala Asp  Ser Val Lys 
    1025                 1030                 1035             


Gly Arg  Phe Thr Ile Ser Arg  Asp Asn Thr Lys Asn  Thr Val Tyr 
    1040                 1045                 1050             


Leu Arg  Met Asn Ser Leu Lys  Pro Glu Asp Thr Ala  Val Tyr Tyr 
    1055                 1060                 1065             


Cys Lys  Ala Ser Ser Pro Val  Leu Asn Asp Ile Trp  Gly Gln Gly 
    1070                 1075                 1080             


Thr Gln  Val Thr Val Ser Ser  
    1085                 1090 


<210>  29
<211>  1097
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human acid alfa-glucosidase (hGAA) fused to CI-M6PR-VHH8 amino 
       acid sequence (hGAA-G4S(3)-VHH8)

<400>  29

Met Gly Ser Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu 
1               5                   10                  15      


Ala Val Cys Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His 
            20                  25                  30          


Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser 
        35                  40                  45              


Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser 
    50                  55                  60                  


Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala 
65                  70                  75                  80  


Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala 
                85                  90                  95      


Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys 
            100                 105                 110         


Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro 
        115                 120                 125             


Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu 
    130                 135                 140                 


Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro 
145                 150                 155                 160 


Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met 
                165                 170                 175     


Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg 
            180                 185                 190         


Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro 
        195                 200                 205             


Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile 
    210                 215                 220                 


Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala 
225                 230                 235                 240 


Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro 
                245                 250                 255     


Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu 
            260                 265                 270         


Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro 
        275                 280                 285             


Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu 
    290                 295                 300                 


Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala 
305                 310                 315                 320 


Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr 
                325                 330                 335     


Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser 
            340                 345                 350         


Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro 
        355                 360                 365             


Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr 
    370                 375                 380                 


Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro 
385                 390                 395                 400 


Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp 
                405                 410                 415     


Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln 
            420                 425                 430         


Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala 
        435                 440                 445             


Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly 
    450                 455                 460                 


Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile 
465                 470                 475                 480 


Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro 
                485                 490                 495     


Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln 
            500                 505                 510         


Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe 
        515                 520                 525             


Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro 
    530                 535                 540                 


Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile 
545                 550                 555                 560 


Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn 
                565                 570                 575     


Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys 
            580                 585                 590         


Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly 
        595                 600                 605             


His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp 
    610                 615                 620                 


Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu 
625                 630                 635                 640 


Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr 
                645                 650                 655     


Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro 
            660                 665                 670         


Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr 
        675                 680                 685             


Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu 
    690                 695                 700                 


Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His 
705                 710                 715                 720 


Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys 
                725                 730                 735     


Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala 
            740                 745                 750         


Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly 
        755                 760                 765             


Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu 
    770                 775                 780                 


Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala 
785                 790                 795                 800 


Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr 
                805                 810                 815     


Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro 
            820                 825                 830         


Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val 
        835                 840                 845             


Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp 
    850                 855                 860                 


Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile 
865                 870                 875                 880 


Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr 
                885                 890                 895     


Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val 
            900                 905                 910         


Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn 
        915                 920                 925             


Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu 
    930                 935                 940                 


Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Leu Gln Val 
                965                 970                 975     


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
            980                 985                 990         


Arg Leu Ser Cys Glu Ala Ser Gly  Arg Thr Phe Asn Thr  Tyr Asn Trp 
        995                 1000                 1005             


Gly Trp  Phe Arg Gln Ala Pro  Gly Lys Glu Arg Glu  Phe Val Ala 
    1010                 1015                 1020             


Ala Ile  Arg Trp Ser Ser Ser  Lys Thr Ser Tyr Ala  Asp Ser Val 
    1025                 1030                 1035             


Lys Gly  Arg Phe Thr Ile Ser  Arg Asp Asn Ala Lys  Asn Thr Ile 
    1040                 1045                 1050             


Tyr Leu  Gln Met Asn Ser Leu  Lys Pro Glu Asp Thr  Ala Val Tyr 
    1055                 1060                 1065             


Tyr Cys  Ala Ala Ser Ile Val  Asp Phe Thr Thr Asn  Pro Ser His 
    1070                 1075                 1080             


Phe Gly  Ser Trp Gly Gln Gly  Thr Gln Val Thr Val  Ser Ser 
    1085                 1090                 1095         


<210>  30
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Cathespin D (hCTSD) fused to CI-M6PR-VHH1 amino acid 
       sequence 

(hCTSD-G4S(3)-VHH1)

<400>  30

Met Gly Ser Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr 
            20                  25                  30          


Ser Ile Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu 
        35                  40                  45              


Ile Ala Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val 
    50                  55                  60                  


Thr Glu Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln 
65                  70                  75                  80  


Tyr Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val 
                85                  90                  95      


Val Phe Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys 
            100                 105                 110         


Lys Leu Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp 
        115                 120                 125             


Lys Ser Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr 
    130                 135                 140                 


Gly Ser Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val 
145                 150                 155                 160 


Pro Cys Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val 
                165                 170                 175     


Glu Arg Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe 
            180                 185                 190         


Ile Ala Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile 
        195                 200                 205             


Ser Val Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys 
    210                 215                 220                 


Leu Val Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp 
225                 230                 235                 240 


Ala Gln Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr 
                245                 250                 255     


Tyr Lys Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp 
            260                 265                 270         


Gln Val His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys 
        275                 280                 285             


Lys Glu Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val 
    290                 295                 300                 


Gly Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val 
305                 310                 315                 320 


Pro Leu Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr 
                325                 330                 335     


Leu Pro Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser 
            340                 345                 350         


Pro Glu Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys 
        355                 360                 365             


Leu Ser Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu 
    370                 375                 380                 


Trp Ile Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp 
385                 390                 395                 400 


Arg Asp Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu Ser Gly 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
            420                 425                 430         


Leu Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        435                 440                 445             


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Arg 
    450                 455                 460                 


Tyr Trp Met Asn Trp Leu Arg Gln Ile Pro Gly Lys Glu Ile Glu Trp 
465                 470                 475                 480 


Val Ser Thr Ile Asn Thr Gly Gly Thr Gly Thr Tyr Tyr Asp Asp Ser 
                485                 490                 495     


Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu 
            500                 505                 510         


Tyr Leu Thr Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
        515                 520                 525             


Cys Ala Arg Gly Ala Thr Tyr Tyr Arg Gly Asn Ser Ala Ile Arg Gly 
    530                 535                 540                 


Gln Gly Thr Gln Val Thr Val Ser Ser 
545                 550             


<210>  31
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Cathespin D (hCTSD) fused to CI-M6PR-VHH5 amino acid 
       sequence 

(hCTSD-G4S(3)-VHH5)

<400>  31

Met Gly Ser Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr 
            20                  25                  30          


Ser Ile Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu 
        35                  40                  45              


Ile Ala Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val 
    50                  55                  60                  


Thr Glu Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln 
65                  70                  75                  80  


Tyr Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val 
                85                  90                  95      


Val Phe Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys 
            100                 105                 110         


Lys Leu Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp 
        115                 120                 125             


Lys Ser Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr 
    130                 135                 140                 


Gly Ser Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val 
145                 150                 155                 160 


Pro Cys Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val 
                165                 170                 175     


Glu Arg Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe 
            180                 185                 190         


Ile Ala Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile 
        195                 200                 205             


Ser Val Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys 
    210                 215                 220                 


Leu Val Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp 
225                 230                 235                 240 


Ala Gln Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr 
                245                 250                 255     


Tyr Lys Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp 
            260                 265                 270         


Gln Val His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys 
        275                 280                 285             


Lys Glu Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val 
    290                 295                 300                 


Gly Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val 
305                 310                 315                 320 


Pro Leu Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr 
                325                 330                 335     


Leu Pro Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser 
            340                 345                 350         


Pro Glu Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys 
        355                 360                 365             


Leu Ser Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu 
    370                 375                 380                 


Trp Ile Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp 
385                 390                 395                 400 


Arg Asp Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu Ser Gly 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
            420                 425                 430         


Leu Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
        435                 440                 445             


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ala Gly Arg Thr Phe Ser Arg 
    450                 455                 460                 


Leu Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
465                 470                 475                 480 


Val Ala Ala Ile Ser Glu Asn Gly Asp Ser Ile His Tyr Ser Asp Ser 
                485                 490                 495     


Val Lys Gly Arg Phe Ala Val Ser Arg Asp Asn Ala Lys Asn Thr Val 
            500                 505                 510         


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
        515                 520                 525             


Cys Ala Ala Asp Arg Ala Ala Tyr Tyr Cys Ser Gly Ser Gly Cys Tyr 
    530                 535                 540                 


Pro Ser Arg Ala Pro Ala Ala Ala Ser Tyr Asp Tyr Trp Gly Gln Gly 
545                 550                 555                 560 


Thr Gln Val Thr Val Ser Ser 
                565         


<210>  32
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Cathespin D (hCTSD) fused to CI-M6PR-VHH7 amino acid 
       sequence 

(hCTSD-G4S(3)-VHH7)

<400>  32

Met Gly Ser Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr 
            20                  25                  30          


Ser Ile Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu 
        35                  40                  45              


Ile Ala Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val 
    50                  55                  60                  


Thr Glu Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln 
65                  70                  75                  80  


Tyr Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val 
                85                  90                  95      


Val Phe Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys 
            100                 105                 110         


Lys Leu Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp 
        115                 120                 125             


Lys Ser Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr 
    130                 135                 140                 


Gly Ser Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val 
145                 150                 155                 160 


Pro Cys Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val 
                165                 170                 175     


Glu Arg Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe 
            180                 185                 190         


Ile Ala Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile 
        195                 200                 205             


Ser Val Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys 
    210                 215                 220                 


Leu Val Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp 
225                 230                 235                 240 


Ala Gln Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr 
                245                 250                 255     


Tyr Lys Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp 
            260                 265                 270         


Gln Val His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys 
        275                 280                 285             


Lys Glu Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val 
    290                 295                 300                 


Gly Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val 
305                 310                 315                 320 


Pro Leu Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr 
                325                 330                 335     


Leu Pro Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser 
            340                 345                 350         


Pro Glu Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys 
        355                 360                 365             


Leu Ser Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu 
    370                 375                 380                 


Trp Ile Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp 
385                 390                 395                 400 


Arg Asp Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu Ser Gly 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
            420                 425                 430         


Leu Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        435                 440                 445             


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp 
    450                 455                 460                 


Asn Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp 
465                 470                 475                 480 


Val Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val 
                485                 490                 495     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
            500                 505                 510         


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        515                 520                 525             


Lys Ala Ser Ser Pro Val Leu Asn Asp Ile Trp Gly Gln Gly Thr Gln 
    530                 535                 540                 


Val Thr Val Ser Ser 
545                 


<210>  33
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Cathespin D (hCTSD) fused to CI-M6PR-VHH8 amino acid 
       sequence 

(hCTSD-G4S(3)-VHH8)

<400>  33

Met Gly Ser Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr 
            20                  25                  30          


Ser Ile Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu 
        35                  40                  45              


Ile Ala Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val 
    50                  55                  60                  


Thr Glu Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln 
65                  70                  75                  80  


Tyr Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val 
                85                  90                  95      


Val Phe Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys 
            100                 105                 110         


Lys Leu Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp 
        115                 120                 125             


Lys Ser Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr 
    130                 135                 140                 


Gly Ser Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val 
145                 150                 155                 160 


Pro Cys Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val 
                165                 170                 175     


Glu Arg Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe 
            180                 185                 190         


Ile Ala Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile 
        195                 200                 205             


Ser Val Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys 
    210                 215                 220                 


Leu Val Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp 
225                 230                 235                 240 


Ala Gln Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr 
                245                 250                 255     


Tyr Lys Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp 
            260                 265                 270         


Gln Val His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys 
        275                 280                 285             


Lys Glu Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val 
    290                 295                 300                 


Gly Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val 
305                 310                 315                 320 


Pro Leu Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr 
                325                 330                 335     


Leu Pro Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser 
            340                 345                 350         


Pro Glu Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys 
        355                 360                 365             


Leu Ser Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu 
    370                 375                 380                 


Trp Ile Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp 
385                 390                 395                 400 


Arg Asp Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu Ser Gly 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
            420                 425                 430         


Leu Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
        435                 440                 445             


Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Phe Asn Thr 
    450                 455                 460                 


Tyr Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
465                 470                 475                 480 


Val Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser 
                485                 490                 495     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile 
            500                 505                 510         


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
        515                 520                 525             


Cys Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly 
    530                 535                 540                 


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
545                 550                 555     


<210>  34
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG(3)HIS(6) tag

<400>  34

Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser Asp Tyr Lys 
1               5                   10                  15      


Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr Lys 
            20                  25                  30          


Asp Asp Asp Asp Lys His His His His His His 
        35                  40              


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from synthetic substrate 
       Mca-GKPILFFRL(dinitrophenyl)DR-NH2

<400>  35

Gly Lys Pro Ile Leu Phe Phe Arg Leu Asp Arg 
1               5                   10      


<210>  36
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
aagaacaagc cgccacc                                                      17


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
gctctcccta ttgtgaagtc gcac                                              24


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
aagaacaagc cgccaccatg                                                   20


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
gtgcgacttc acaataggga gagc                                              24


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
caccgatgga cgtgaacttg tgcag                                             25


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
aaacctgcac aagttcacgt ccatc                                             25


<210>  42
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
caccggcaag ttcacatcta tccgt                                             25


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
aaacacggat agatgtgaac ttgcc                                             25


<210>  44
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
agcctatgga aaaacgccag caacgc                                            26


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
ggcaatgggt tgccattcac tg                                                22


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46
gactctgaga ttccccaggg gc                                                22


<210>  47
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
gtccatgtag ttcttgagca cctcgg                                            26


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
caggagtttg tgacatgttg tggc                                              24


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
ctagaggcac ctaggtgcat g                                                 21


<210>  50
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50
gcactcacat ccaggtagtt tttgagtaac                                        30


<210>  51
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
gcgccgtgtg tgagcacgac ctgaaaaccc ggacc                                  35


<210>  52
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
caggtcgtgc tcacacacgg cgctagaagg tccacactgc acg                         43


<210>  53
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
gtgtatgcac ctcctgaaaa cccggaccta ccacagcg                               38


<210>  54
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
gggttttcag gaggtgcata cacacggcgc tagaagg                                37


<210>  55
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
gcacgacctg gacacccgga cctaccacag cgtgggc                                37


<210>  56
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
ggtccgggtg tccaggtcgt gcatacacac ggcgc                                  35


<210>  57
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
cacccctgag cgtgtgaccg ccacagagtg tgtgc                                  35


<210>  58
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
ggcggtcaca cgctcagggg tgcccagtgt cttgcc                                 36


<210>  59
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  59
ccgccacatt ctgtgtgcac tacttcgagt ggcgg                                  35


<210>  60
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
gtagtgcaca cagaatgtgg cggtcacaaa ctcagggg                               38


<210>  61
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
ccctctgatc ttcctgagcg gcgcctacct ggtggacgac agcg                        44


<210>  62
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
ggcgccgctc aggaagatca gagggttcag atcgtgcttc cgc                         43


<210>  63
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
gcggcgccta cgacgtggac gacagcgatc ctgataccag cc                          42


<210>  64
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
gctgtcgtcc acgtcgtagg cgccgctcag cttgatcaga ggg                         43


<210>  65
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
cagcgacggc tttctgaccc tgatctactt tggcggcg                               38


<210>  66
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
cagggtcaga aagccgtcgc tgtatctcag ggtctg                                 36


<210>  67
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  67
gatcaatttc cggtgtaaca agaccgccgg caacgacggc                             40


<210>  68
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  68
ggtcttgtta caccggaaat tgatcacgct cattctctgg                             40


<210>  69
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
ggactgcacc tacgagttca cctgggacac agagtatgcc tgcg                        44


<210>  70
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
cccaggtgaa ctcgtaggtg cagtccacct cgcc                                   34


<210>  71
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H11

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp Asn 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asn Leu 
65                  70                  75                  80  


Tyr Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Val His His His 
                85                  90                  95      


Tyr Tyr Cys Asn Ser Gly Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  72
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2H79

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Gln Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Gly Ala Phe Ser Thr Tyr 
            20                  25                  30          


His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Gly Gly Ser Ser Ser Thr Lys Tyr Val Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Gln Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Ser Pro Gln Gly Lys Trp Asn Ala Leu Val Gly Gly Thr 
            100                 105                 110         


Pro Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  73
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H52

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Trp Asp Ser Tyr 
            20                  25                  30          


Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Leu Asp Val Asp Asp Gly Ser Ile Tyr Tyr His Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Asn Arg Ala Ser Met Arg Phe Arg Arg Cys Leu Gln Val 
            100                 105                 110         


Leu Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  74
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H21

<400>  74

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Thr Leu 
            20                  25                  30          


His Met Gly Trp Phe His Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Asp Thr Tyr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ile Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Thr Gly Pro Gly Gly Trp Ala Arg Leu Arg Ala His Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H37

<400>  75

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Pro Ser Gly Arg Thr Tyr Ser Thr Tyr 
            20                  25                  30          


Trp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Arg Ile Asn Trp Ser Asp Gly Ser Thr Phe Tyr Thr Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Ala Arg Thr Val Val Ser Leu Asp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  76
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2H74

<400>  76

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Pro Ser Gly Arg Thr Tyr Ser Thr Tyr 
            20                  25                  30          


Trp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Arg Ile Asn Trp Ser Asp Gly Ser Thr Phe Tyr Thr Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Leu Ala Arg Thr Val Val Ser Leu Asp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  77
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H74

<400>  77

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Leu Glu Asp Tyr 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp His Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Tyr Ser Ser Leu Ala Arg Ile Glu Thr Asn Trp His Asp 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  78
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H44

<400>  78

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Val Ile Asp Trp Ser Gly Gly Val Thr Tyr Tyr Asp Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Val Ser Pro Arg Ser Gly Ile Trp Tyr Tyr Ser Arg Arg 
            100                 105                 110         


Asn Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  79
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2H60

<400>  79

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Met Ser Ser Ser Thr Asp 
            20                  25                  30          


Thr Met Thr Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Tyr Ile Thr Thr Thr Gly Val Thr Asn Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ser Ala Trp Asn Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H73

<400>  80

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr Leu Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Ala Ile Val Arg Ile Thr Thr Thr Arg Asp Tyr His 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  81
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH2H14

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr Val Ser Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Gln Ile Val Arg Ile Thr Thr Thr Arg Asp Tyr His 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  82
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH1H06

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Gly Ser Ile Ala 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Gly Arg Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Ala Arg Tyr Tyr Ile Ser Leu Tyr Tyr Tyr Arg Met Gln Asn Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  83
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_M85E mutant

<400>  83

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Glu His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  84
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_D87L mutant

<400>  84

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  85
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_K89D mutant

<400>  85

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Asp Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  86
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_F143R mutant

<400>  86

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Arg Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  87
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_E148F mutant

<400>  87

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Phe Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  88
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_K191F mutant

<400>  88

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Phe Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  89
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_L197D mutant

<400>  89

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Asp Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  90
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_D409F mutant

<400>  90

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Phe Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  91
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_E433R mutant

<400>  91

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Arg Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Phe Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  92
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI-M6PR_F457E mutant

<400>  92

Gln Ala Ala Pro Phe Pro Glu Leu Cys Ser Tyr Thr Trp Glu Ala Val 
1               5                   10                  15      


Asp Thr Lys Asn Asn Val Leu Tyr Lys Ile Asn Ile Cys Gly Ser Val 
            20                  25                  30          


Asp Ile Val Gln Cys Gly Pro Ser Ser Ala Val Cys Met His Asp Leu 
        35                  40                  45              


Lys Thr Arg Thr Tyr His Ser Val Gly Asp Ser Val Leu Arg Ser Ala 
    50                  55                  60                  


Thr Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln 
65                  70                  75                  80  


Gly Thr Asn His Arg Val Gln Ser Ser Ile Ala Phe Leu Cys Gly Lys 
                85                  90                  95      


Thr Leu Gly Thr Pro Glu Phe Val Thr Ala Thr Glu Cys Val His Tyr 
            100                 105                 110         


Phe Glu Trp Arg Thr Thr Ala Ala Cys Lys Lys Asp Ile Phe Lys Ala 
        115                 120                 125             


Asn Lys Glu Val Pro Cys Tyr Val Phe Asp Glu Glu Leu Arg Lys His 
    130                 135                 140                 


Asp Leu Asn Pro Leu Ile Lys Leu Ser Gly Ala Tyr Leu Val Asp Asp 
145                 150                 155                 160 


Ser Asp Pro Asp Thr Ser Leu Phe Ile Asn Val Cys Arg Asp Ile Asp 
                165                 170                 175     


Thr Leu Arg Asp Pro Gly Ser Gln Leu Arg Ala Cys Pro Pro Gly Thr 
            180                 185                 190         


Ala Ala Cys Leu Val Arg Gly His Gln Ala Phe Asp Val Gly Gln Pro 
        195                 200                 205             


Arg Asp Gly Leu Lys Val Val Arg Lys Asp Arg Leu Val Leu Ser Tyr 
    210                 215                 220                 


Val Arg Glu Glu Ala Gly Lys Leu Asp Phe Cys Asp Gly His Ser Pro 
225                 230                 235                 240 


Ala Val Thr Ile Thr Phe Val Cys Pro Ser Glu Arg Arg Glu Gly Thr 
                245                 250                 255     


Ile Pro Lys Leu Thr Ala Lys Ser Asn Cys Arg Tyr Glu Ile Glu Trp 
            260                 265                 270         


Ile Thr Glu Tyr Ala Cys His Arg Asp Tyr Leu Glu Ser Lys Thr Cys 
        275                 280                 285             


Ser Leu Ser Gly Glu Gln Gln Asp Val Ser Ile Asp Leu Thr Pro Leu 
    290                 295                 300                 


Ala Gln Ser Gly Gly Ser Ser Tyr Ile Ser Asp Gly Lys Glu Tyr Leu 
305                 310                 315                 320 


Phe Tyr Leu Asn Val Cys Gly Glu Thr Glu Ile Gln Phe Cys Asn Lys 
                325                 330                 335     


Lys Gln Ala Ala Val Cys Gln Val Lys Lys Ser Asp Thr Ser Gln Val 
            340                 345                 350         


Lys Ala Ala Gly Arg Tyr His Asn Gln Thr Leu Arg Tyr Ser Asp Gly 
        355                 360                 365             


Asp Leu Thr Leu Ile Tyr Phe Gly Gly Asp Glu Cys Ser Ser Gly Phe 
    370                 375                 380                 


Gln Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn 
385                 390                 395                 400 


Asp Gly Lys Gly Thr Pro Val Phe Thr Gly Glu Val Asp Cys Thr Tyr 
                405                 410                 415     


Glu Phe Thr Trp Asp Thr Glu Tyr Ala Cys Val His His His His His 
            420                 425                 430         


His 
    


<210>  93
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH7h1

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp Asn 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Ser Ser Pro Val Leu Asn Asp Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  94
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH7h2

<400>  94

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp Asn 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Ser Ser Pro Val Leu Asn Asp Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  95
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH7h3

<400>  95

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp Asn 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Ser Ser Pro Val Leu Asn Asp Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  96
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH7hWN

<400>  96

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Asp Asn 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Gly Trp Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Ser Ser Pro Val Leu Asn Asp Ile Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  97
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8h1

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  98
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8h2

<400>  98

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  99
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8h3

<400>  99

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  100
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8h4

<400>  100

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  101
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8h5

<400>  101

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  102
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH8hWN

<400>  102

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asn Trp Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  103

Gly Ile Ile Phe Ser Asp Asn Arg Met Asp 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  104

Gly Phe Thr Phe Asp Arg Tyr Trp Met Asn 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  105

Gly Ile Ile Phe Ser Asp Asn Arg Met Asp 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  106

Gly Gly Ala Phe Ser Thr Tyr His Met Gly 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  107

Gly Arg Thr Phe Asn Thr Tyr Asn Trp Gly 
1               5                   10  


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  108

Gly Arg Thr Phe Ser Arg Leu Ala Met Gly 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  109

Gly Phe Thr Trp Asp Ser Tyr Val Ile Gly 
1               5                   10  


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  110

Thr Leu Ala Ser Tyr Gly Trp Lys Thr 
1               5                   


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  111

Thr Ile Asn Thr Gly Gly Thr Gly Thr Tyr 
1               5                   10  


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  112

Thr Leu Ala Ser Tyr Gly Trp Lys Thr 
1               5                   


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  113

Ala Ile Thr Arg Gly Gly Ser Ser Ser Thr Lys 
1               5                   10      


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  114

Ala Ile Arg Trp Ser Ser Ser Lys Thr Ser 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  115

Ala Ile Ser Glu Asn Gly Asp Ser Ile His 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  116

Cys Leu Asp Val Asp Asp Gly Ser Ile Tyr 
1               5                   10  


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  117

Ser Ser Pro Val Leu Asn Asp Ile 
1               5               


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  118

Gly Ala Thr Tyr Tyr Arg Gly Asn Ser Ala Ile 
1               5                   10      


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  119

Asn Ser Gly Gln Tyr 
1               5   


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  120

Ser Pro Gln Gly Lys Trp Asn Ala Leu Val Gly Gly Thr Pro Asp Tyr 
1               5                   10                  15      


<210>  121
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  121

Ser Ile Val Asp Phe Thr Thr Asn Pro Ser His Phe Gly Ser 
1               5                   10                  


<210>  122
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  122

Asp Arg Ala Ala Tyr Tyr Cys Ser Gly Ser Gly Cys Tyr Pro Ser Arg 
1               5                   10                  15      


Ala Pro Ala Ala Ala Ser Tyr Asp Tyr 
            20                  25  


<210>  123
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence of CI-M6PR VHHs binding to the epitope of VHH7 or 
       VHH8

<400>  123

Val Asn Arg Ala Ser Met Arg Phe Arg Arg Cys Leu Gln Val Leu Arg 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  124
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13A12

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Gly Ala Asn 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Val Pro Gly Lys Glu Arg Asp Val Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Asp Ser Thr Tyr Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Thr Thr Asp Gly Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  125
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13B12

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Gly Ala Asn 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Val Pro Gly Lys Glu Arg Asp Val Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Val Asp Ser Thr Tyr Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Thr Thr Asp Gly Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  126
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13A2

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Ala Asn 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Val Pro Gly Lys Glu Arg Asp Val Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Asp Ser Thr Tyr Tyr Gly Asp Ser Val Arg 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Ile Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Arg Thr Thr Asp Gly Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  127
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig 52.: 13C11

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Asp Ser Ile Tyr His Glu Gly Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Asn Gly Pro Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  128
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13G10

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Asp Ser Ile Tyr His Glu Asp Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Asn Gly Pro Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  129
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13E5

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Asp Ser Thr Tyr His Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Asn Gly Pro Gly Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  130
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13A10

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Tyr Met Ala Trp Tyr Arg Gln Glu Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ser Met Ser Trp Arg Gly Asp Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Lys Ala Asn Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  131
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13D11

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ser Met Ser Trp Arg Arg Asp Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Lys Ala Asn Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  132
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13A3

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Leu Asn 
            20                  25                  30          


Tyr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ser Met Ser Arg Arg Ser Asp Ser Thr Tyr Leu Ala Asp Ala Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Met Asn Asn Ala Gly Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Lys Ala Asn Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  133
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13F4

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Tyr Met Ala Trp Tyr Arg Gln Thr Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ser Met Ser Arg Arg Ser Asp Ser Thr Tyr Leu Ala Asp Ala Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Gly Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Lys Ala Asn Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  134
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13G12

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ile Ser 
            20                  25                  30          


Ser Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Val Val Val 
        35                  40                  45              


Ala Ser Ile Ala Trp Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ala Tyr Thr Gln Val Ser Val Asn Asn Arg Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  135
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13E8

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Ser Pro Met Gly 
            20                  25                  30          


Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ile Met 
        35                  40                  45              


Pro Ser Ser Gly Pro Pro Ile Tyr Ala Asp Ser Val Gln Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Gly Gly 
                85                  90                  95      


Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 


<210>  136
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13B7

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Ser Pro Met Gly 
            20                  25                  30          


Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ile Met 
        35                  40                  45              


Pro Ser Ser Gly Thr Pro Ile Tyr Ala Asp Ser Val Gln Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Gly Gly 
                85                  90                  95      


Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 


<210>  137
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13A8

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Pro Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Lys Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Arg Asp Ser Ser Ser Tyr Asp His Arg Arg Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  138
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fig. 52: 13F11

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Arg Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ala Gly Gly Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Arg Ala Trp Val Gln Arg Met Pro Lys Asp Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic substrate (Mca-GKPILFFRL(dinitrophenyl)DR-NH2)

<400>  139

Gly Lys Pro Ile Leu Phe Phe Arg Leu 
1               5                   


