                         SEQUENCE LISTING

<110>  NOVOZYMES A/S
 
<120>  INACTIVE HEME POLYPEPTIDES

<130>  NZ 15220-WO-PCT

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  1089
<212>  DNA
<213>  Coprinus cinereus

<400>  1
atgaagctct cgcttttgtc caccttcgct gctgtcatca tcggtgccct cgctctaccc       60

cagggtcctg gaggaggcgg gtcagtcact tgccccggtg gacagtccac ttcgaacagc      120

cagtgctgcg tctggttcga cgttctagac gatcttcaga ccaacttcta ccaagggtcc      180

aagtgtgaga gccctgttcg caagattctt agaattgttt tccatgacgc gatcggattt      240

tcgccggcgt tgactgctgc tggtcaattc ggtggtggag gagctgatgg ctccatcatt      300

gcgcattcga acatcgaatt ggccttcccg gctaatggcg gcctcaccga caccgtcgaa      360

gccctccgcg cggtcggtat caaccacggt gtctctttcg gcgatctcat ccaattcgcc      420

actgccgtcg gcatgtccaa ctgccctggc tctccccgac ttgagttctt gacgggcagg      480

agcaacagtt cccaaccctc ccctccttcg ttgatccccg gtcccggaaa cactgtcact      540

gctatcttgg atcgtatggg cgatgcaggc ttcagccctg atgaagtagt tgacttgctt      600

gctgcgcata gtttggcttc tcaggagggt ttgaactcgg ccatcttcag gtctcctttg      660

gactcgaccc ctcaagtttt cgatacccag ttctacattg agaccttgct caagggtacc      720

actcagcctg gcccttctct cggctttgca gaggagctct cccccttccc tggcgaattc      780

cgcatgaggt ccgatgctct cttggctcgc gactcccgaa ccgcctgccg atggcaatcc      840

atgaccagca gcaatgaagt tatgggccag cgataccgcg ccgccatggc caagatgtct      900

gttctcggct tcgacaggaa cgccctcacc gattgctctg acgttattcc ttctgctgtg      960

tccaacaacg ctgctcctgt tatccctggt ggccttactg tcgatgatat cgaggtttcg     1020

tgcccgagcg agcctttccc tgaaattgct accgcctcag gccctctccc ctccctcgct     1080

cctgctcct                                                             1089


<210>  2
<211>  363
<212>  PRT
<213>  Coprinus cinereus

<400>  2

Met Lys Leu Ser Leu Leu Ser Thr Phe Ala Ala Val Ile Ile Gly Ala 
1               5                   10                  15      


Leu Ala Leu Pro Gln Gly Pro Gly Gly Gly Gly Ser Val Thr Cys Pro 
            20                  25                  30          


Gly Gly Gln Ser Thr Ser Asn Ser Gln Cys Cys Val Trp Phe Asp Val 
        35                  40                  45              


Leu Asp Asp Leu Gln Thr Asn Phe Tyr Gln Gly Ser Lys Cys Glu Ser 
    50                  55                  60                  


Pro Val Arg Lys Ile Leu Arg Ile Val Phe His Asp Ala Ile Gly Phe 
65                  70                  75                  80  


Ser Pro Ala Leu Thr Ala Ala Gly Gln Phe Gly Gly Gly Gly Ala Asp 
                85                  90                  95      


Gly Ser Ile Ile Ala His Ser Asn Ile Glu Leu Ala Phe Pro Ala Asn 
            100                 105                 110         


Gly Gly Leu Thr Asp Thr Val Glu Ala Leu Arg Ala Val Gly Ile Asn 
        115                 120                 125             


His Gly Val Ser Phe Gly Asp Leu Ile Gln Phe Ala Thr Ala Val Gly 
    130                 135                 140                 


Met Ser Asn Cys Pro Gly Ser Pro Arg Leu Glu Phe Leu Thr Gly Arg 
145                 150                 155                 160 


Ser Asn Ser Ser Gln Pro Ser Pro Pro Ser Leu Ile Pro Gly Pro Gly 
                165                 170                 175     


Asn Thr Val Thr Ala Ile Leu Asp Arg Met Gly Asp Ala Gly Phe Ser 
            180                 185                 190         


Pro Asp Glu Val Val Asp Leu Leu Ala Ala His Ser Leu Ala Ser Gln 
        195                 200                 205             


Glu Gly Leu Asn Ser Ala Ile Phe Arg Ser Pro Leu Asp Ser Thr Pro 
    210                 215                 220                 


Gln Val Phe Asp Thr Gln Phe Tyr Ile Glu Thr Leu Leu Lys Gly Thr 
225                 230                 235                 240 


Thr Gln Pro Gly Pro Ser Leu Gly Phe Ala Glu Glu Leu Ser Pro Phe 
                245                 250                 255     


Pro Gly Glu Phe Arg Met Arg Ser Asp Ala Leu Leu Ala Arg Asp Ser 
            260                 265                 270         


Arg Thr Ala Cys Arg Trp Gln Ser Met Thr Ser Ser Asn Glu Val Met 
        275                 280                 285             


Gly Gln Arg Tyr Arg Ala Ala Met Ala Lys Met Ser Val Leu Gly Phe 
    290                 295                 300                 


Asp Arg Asn Ala Leu Thr Asp Cys Ser Asp Val Ile Pro Ser Ala Val 
305                 310                 315                 320 


Ser Asn Asn Ala Ala Pro Val Ile Pro Gly Gly Leu Thr Val Asp Asp 
                325                 330                 335     


Ile Glu Val Ser Cys Pro Ser Glu Pro Phe Pro Glu Ile Ala Thr Ala 
            340                 345                 350         


Ser Gly Pro Leu Pro Ser Leu Ala Pro Ala Pro 
        355                 360             


<210>  3
<211>  1161
<212>  DNA
<213>  Coprinus cinereus

<400>  3
atgatttcga cctcgaagca tctcttcgtc ttgctcccgc tcttcttggt ctcgcatctc       60

tcgctcgtcc tcggtttccc tgcatacgcc tccttgggag gcttgaccga acgtcaggtg      120

gaggagtata cgtcgaagtt gcctatcgtg ttccctcctc ctcctccgga acctatcaaa      180

gatccttggc tcaagctcgt gaacgatagg gcacacccct ggaggccttt gaggcgaggc      240

gacgtgcgag gaccctgtcc cggtctcaac accctcgcat cccatggcta tttgcctcgc      300

gacggcgtcg ccacaccggc acagatcatc acagcggtcc aggaaggctt caacatggaa      360

tacggcatcg ccacattcgt cacctatgca gcccacctcg tggacggaaa cccgctcacc      420

aacttgatct ccattggagg caagacccgg aaaactggtc cggaccctcc tcctcctgcg      480

atcgtgggag gattgaacac acatgcggtc ttcgagggcg acgcgtccat gacacgaggc      540

gatttccatt tgggtgacaa cttcaacttc aaccagactc tctgggagca gttcaaggat      600

tactcgaacc gctatggtgg aggaaggtat aacctcactg cagcagccga gttgcgttgg      660

gcacgaatcc agcagtccat ggcaaccaac ggacagttcg acttcacctc gcccaggtac      720

ttcacagcct atgccgaatc cgtgttccct atcaacttct tcaccgacgg acgattgttc      780

acctcgaaca ccactgcacc tggacccgac atggattcgg cgttgtcgtt cttccgagac      840

cacaggtatc cgaaagattt ccatcgagcg cctgtccctt cgggtgcacg gggattggac      900

gtcgtcgcag cagcgtaccc cattcagcct ggctacaacg ccgatggcaa ggtcaacaac      960

tatgtcttgg accccacgtc cgcagatttc accaagttct gtctcttgta cgagaacttc     1020

gtgttgaaga ccgtcaaggg tttgtacccc aaccctaagg gcttcctcag gaaggcgttg     1080

gagacaaact tggagtattt ctaccagtcc ttccctggct ccggtggctg tccccaggtg     1140

ttcccctggg gtaagtcgga t                                               1161


<210>  4
<211>  387
<212>  PRT
<213>  Coprinus cinereus

<400>  4

Met Ile Ser Thr Ser Lys His Leu Phe Val Leu Leu Pro Leu Phe Leu 
1               5                   10                  15      


Val Ser His Leu Ser Leu Val Leu Gly Phe Pro Ala Tyr Ala Ser Leu 
            20                  25                  30          


Gly Gly Leu Thr Glu Arg Gln Val Glu Glu Tyr Thr Ser Lys Leu Pro 
        35                  40                  45              


Ile Val Phe Pro Pro Pro Pro Pro Glu Pro Ile Lys Asp Pro Trp Leu 
    50                  55                  60                  


Lys Leu Val Asn Asp Arg Ala His Pro Trp Arg Pro Leu Arg Arg Gly 
65                  70                  75                  80  


Asp Val Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly 
                85                  90                  95      


Tyr Leu Pro Arg Asp Gly Val Ala Thr Pro Ala Gln Ile Ile Thr Ala 
            100                 105                 110         


Val Gln Glu Gly Phe Asn Met Glu Tyr Gly Ile Ala Thr Phe Val Thr 
        115                 120                 125             


Tyr Ala Ala His Leu Val Asp Gly Asn Pro Leu Thr Asn Leu Ile Ser 
    130                 135                 140                 


Ile Gly Gly Lys Thr Arg Lys Thr Gly Pro Asp Pro Pro Pro Pro Ala 
145                 150                 155                 160 


Ile Val Gly Gly Leu Asn Thr His Ala Val Phe Glu Gly Asp Ala Ser 
                165                 170                 175     


Met Thr Arg Gly Asp Phe His Leu Gly Asp Asn Phe Asn Phe Asn Gln 
            180                 185                 190         


Thr Leu Trp Glu Gln Phe Lys Asp Tyr Ser Asn Arg Tyr Gly Gly Gly 
        195                 200                 205             


Arg Tyr Asn Leu Thr Ala Ala Ala Glu Leu Arg Trp Ala Arg Ile Gln 
    210                 215                 220                 


Gln Ser Met Ala Thr Asn Gly Gln Phe Asp Phe Thr Ser Pro Arg Tyr 
225                 230                 235                 240 


Phe Thr Ala Tyr Ala Glu Ser Val Phe Pro Ile Asn Phe Phe Thr Asp 
                245                 250                 255     


Gly Arg Leu Phe Thr Ser Asn Thr Thr Ala Pro Gly Pro Asp Met Asp 
            260                 265                 270         


Ser Ala Leu Ser Phe Phe Arg Asp His Arg Tyr Pro Lys Asp Phe His 
        275                 280                 285             


Arg Ala Pro Val Pro Ser Gly Ala Arg Gly Leu Asp Val Val Ala Ala 
    290                 295                 300                 


Ala Tyr Pro Ile Gln Pro Gly Tyr Asn Ala Asp Gly Lys Val Asn Asn 
305                 310                 315                 320 


Tyr Val Leu Asp Pro Thr Ser Ala Asp Phe Thr Lys Phe Cys Leu Leu 
                325                 330                 335     


Tyr Glu Asn Phe Val Leu Lys Thr Val Lys Gly Leu Tyr Pro Asn Pro 
            340                 345                 350         


Lys Gly Phe Leu Arg Lys Ala Leu Glu Thr Asn Leu Glu Tyr Phe Tyr 
        355                 360                 365             


Gln Ser Phe Pro Gly Ser Gly Gly Cys Pro Gln Val Phe Pro Trp Gly 
    370                 375                 380                 


Lys Ser Asp 
385         


<210>  5
<211>  939
<212>  DNA
<213>  Humicola insolens

<400>  5
atgatgcaat ttaccaccat cctctccatc ggtatcaccg tcttcggact gggtatgtac       60

accaccccct tgcgtctgtt atctgtgaca tatgtagctg actggtcagc caacaccgga      120

gcctttgcag caccccagcc ggtacccgag gcttacgctg tttctgatcc cgaggctcat      180

cctgacgatt ttgctggtat ggatgcgaac caacttcaga aacgtggctt ccatgattgg      240

gaacctcccg gtcctaaaga cgtgcgagca ccgtgtccga tgctcaacac gttggccaac      300

cacggcttcc tccctcacca tggacgggat ttgacgagga agcaggtggt cgacggcctc      360

tacaacggat tgaacatcaa caagactgcc gcatccgcgt tgttcgattt cgcactcatg      420

acatcgccca agccgaacgc aacaaccttc tccctcaacg acttgggcag gcataacatc      480

ttggagcacg acgcctcgct ctcgcgcacc gacgcctact tcggtgatgt gctcgccttc      540

aacaaaacca tcttcgagga gaccaagagg cactggggaa aatcgcccat cctcgatgtc      600

accgcagcag ccagggcaag gctcggtcgg attcagacgt ccaaggcgac caaccccgag      660

tatttcatgt cggagctcgg caacatcttc acttacggtg agtcggtcgc ctacatcatg      720

ttgattggag acgcgaagac cggaaaagcc aacaggcgct gggtcgagta ttggttcgag      780

aacgagcgcc tccctacgca tttgggatgg aggcgaccgt ccaaagagct cacatcggac      840

gtcctcgatg cctacatctc gctcatccag aacatcacgc tcacgctccc tggcggaacc      900

gaccctgtga aacgaagggc agcgtcccat ttcggctgg                             939


<210>  6
<211>  313
<212>  PRT
<213>  Humicola insolens

<400>  6

Met Met Gln Phe Thr Thr Ile Leu Ser Ile Gly Ile Thr Val Phe Gly 
1               5                   10                  15      


Leu Gly Met Tyr Thr Thr Pro Leu Arg Leu Leu Ser Val Thr Tyr Val 
            20                  25                  30          


Ala Asp Trp Ser Ala Asn Thr Gly Ala Phe Ala Ala Pro Gln Pro Val 
        35                  40                  45              


Pro Glu Ala Tyr Ala Val Ser Asp Pro Glu Ala His Pro Asp Asp Phe 
    50                  55                  60                  


Ala Gly Met Asp Ala Asn Gln Leu Gln Lys Arg Gly Phe His Asp Trp 
65                  70                  75                  80  


Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro Cys Pro Met Leu Asn 
                85                  90                  95      


Thr Leu Ala Asn His Gly Phe Leu Pro His His Gly Arg Asp Leu Thr 
            100                 105                 110         


Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly Leu Asn Ile Asn Lys 
        115                 120                 125             


Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu Met Thr Ser Pro Lys 
    130                 135                 140                 


Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu Gly Arg His Asn Ile 
145                 150                 155                 160 


Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp Ala Tyr Phe Gly Asp 
                165                 170                 175     


Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu Thr Lys Arg His Trp 
            180                 185                 190         


Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala Ala Arg Ala Arg Leu 
        195                 200                 205             


Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro Glu Tyr Phe Met Ser 
    210                 215                 220                 


Glu Leu Gly Asn Ile Phe Thr Tyr Gly Glu Ser Val Ala Tyr Ile Met 
225                 230                 235                 240 


Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn Arg Arg Trp Val Glu 
                245                 250                 255     


Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His Leu Gly Trp Arg Arg 
            260                 265                 270         


Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp Ala Tyr Ile Ser Leu 
        275                 280                 285             


Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly Thr Asp Pro Val Lys 
    290                 295                 300                 


Arg Arg Ala Ala Ser His Phe Gly Trp 
305                 310             


<210>  7
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIP H55D

<400>  7
atgaagctct cgcttttgtc caccttcgct gctgtcatca tcggtgccct cgctctaccc       60

cagggtcctg gaggaggcgg gtcagtcact tgccccggtg gacagtccac ctcgaacagc      120

cagtgctgcg tctggttcga cgttctagac gatcttcaga ccaacttcta ccaagggtcc      180

aagtgtgaga gccctgttcg caagattctt agaattgttt tcgatgacgc gatcggattt      240

tcgccggcgt tgactgctgc tggtcaattc ggtggtggag gagctgatgg ctccatcatt      300

gcgcattcga acatcgaatt ggccttcccg gctaatggcg gcctcaccga caccgtcgaa      360

gccctccgcg cggtcggtat caaccacggt gtctctttcg gcgatctcat ccaattcgcc      420

actgccgtcg gcatgtccaa ctgccctggc tctccccgac ttgagttctt gacgggcagg      480

agcaacagtt cccaaccctc ccctccttcg ttgatccccg gtcccggaaa cactgtcact      540

gctatcttgg atcgtatggg cgatgcaggc ttcagccctg atgaagtagt tgacttgctt      600

gctgcgcata gtttggcttc tcaggagggt ttgaactcgg ccatcttcag gtctcctttg      660

gactcgaccc ctcaagtttt cgatacccag ttctacattg agaccttgct caagggtacc      720

actcagcctg gcccttctct cggctttgca gaggagctct cccccttccc tggcgaattc      780

cgcatgaggt ccgatgctct cttggctcgc gactcccgaa ccgcctgccg atggcaatcc      840

atgaccagca gcaatgaagt tatgggccag cgataccgcg ccgccatggc caagatgtct      900

gttctcggct tcgacaggaa cgccctcacc gattgctctg acgttattcc ttctgctgtg      960

tccaacaacg ctgctcctgt tatccctggt ggccttactg tcgatgatat cgaggtttcg     1020

tgcccgagcg agcctttccc tgaaattgct accgcctcag gccctctccc ctccctcgct     1080

cctgctcct                                                             1089


<210>  8
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIP H55D

<400>  8

Gln Gly Pro Gly Gly Gly Gly Ser Val Thr Cys Pro Gly Gly Gln Ser 
1               5                   10                  15      


Thr Ser Asn Ser Gln Cys Cys Val Trp Phe Asp Val Leu Asp Asp Leu 
            20                  25                  30          


Gln Thr Asn Phe Tyr Gln Gly Ser Lys Cys Glu Ser Pro Val Arg Lys 
        35                  40                  45              


Ile Leu Arg Ile Val Phe Asp Asp Ala Ile Gly Phe Ser Pro Ala Leu 
    50                  55                  60                  


Thr Ala Ala Gly Gln Phe Gly Gly Gly Gly Ala Asp Gly Ser Ile Ile 
65                  70                  75                  80  


Ala His Ser Asn Ile Glu Leu Ala Phe Pro Ala Asn Gly Gly Leu Thr 
                85                  90                  95      


Asp Thr Val Glu Ala Leu Arg Ala Val Gly Ile Asn His Gly Val Ser 
            100                 105                 110         


Phe Gly Asp Leu Ile Gln Phe Ala Thr Ala Val Gly Met Ser Asn Cys 
        115                 120                 125             


Pro Gly Ser Pro Arg Leu Glu Phe Leu Thr Gly Arg Ser Asn Ser Ser 
    130                 135                 140                 


Gln Pro Ser Pro Pro Ser Leu Ile Pro Gly Pro Gly Asn Thr Val Thr 
145                 150                 155                 160 


Ala Ile Leu Asp Arg Met Gly Asp Ala Gly Phe Ser Pro Asp Glu Val 
                165                 170                 175     


Val Asp Leu Leu Ala Ala His Ser Leu Ala Ser Gln Glu Gly Leu Asn 
            180                 185                 190         


Ser Ala Ile Phe Arg Ser Pro Leu Asp Ser Thr Pro Gln Val Phe Asp 
        195                 200                 205             


Thr Gln Phe Tyr Ile Glu Thr Leu Leu Lys Gly Thr Thr Gln Pro Gly 
    210                 215                 220                 


Pro Ser Leu Gly Phe Ala Glu Glu Leu Ser Pro Phe Pro Gly Glu Phe 
225                 230                 235                 240 


Arg Met Arg Ser Asp Ala Leu Leu Ala Arg Asp Ser Arg Thr Ala Cys 
                245                 250                 255     


Arg Trp Gln Ser Met Thr Ser Ser Asn Glu Val Met Gly Gln Arg Tyr 
            260                 265                 270         


Arg Ala Ala Met Ala Lys Met Ser Val Leu Gly Phe Asp Arg Asn Ala 
        275                 280                 285             


Leu Thr Asp Cys Ser Asp Val Ile Pro Ser Ala Val Ser Asn Asn Ala 
    290                 295                 300                 


Ala Pro Val Ile Pro Gly Gly Leu Thr Val Asp Asp Ile Glu Val Ser 
305                 310                 315                 320 


Cys Pro Ser Glu Pro Phe Pro Glu Ile Ala Thr Ala Ser Gly Pro Leu 
                325                 330                 335     


Pro Ser Leu Ala Pro Ala Pro 
            340             


<210>  9
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIP H55W

<400>  9
atgaagctct cgcttttgtc caccttcgct gctgtcatca tcggtgccct cgctctaccc       60

cagggtcctg gaggaggcgg gtcagtcact tgccccggtg gacagtccac ttcgaacagc      120

cagtgctgcg tctggttcga cgttctagac gatcttcaga ccaacttcta ccaagggtcc      180

aagtgtgaga gccctgttcg caagattctt agaattgttt tctgggacgc gatcggattt      240

tcgccggcgt tgactgctgc tggtcaattc ggtggtggag gagctgatgg ctccatcatt      300

gcgcattcga acatcgaatt ggccttcccg gctaatggcg gcctcaccga caccgtcgaa      360

gccctccgcg cggtcggtat caaccacggt gtctctttcg gcgatctcat ccaattcgcc      420

actgccgtcg gcatgtccaa ctgccctggc tctccccgac ttgagttctt gacgggcagg      480

agcaacagtt cccaaccctc ccctccttcg ttgatccccg gtcccggaaa cactgtcact      540

gctatcttgg atcgtatggg cgatgcaggc ttcagccctg atgaagtagt tgacttgctt      600

gctgcgcata gtttggcttc tcaggagggt ttgaactcgg ccatcttcag gtctcctttg      660

gactcgaccc ctcaagtttt cgatacccag ttctacattg agaccttgct caagggtacc      720

actcagcctg gcccttctct cggctttgca gaggagctct cccccttccc tggcgaattc      780

cgcatgaggt ccgatgctct cttggctcgc gactcccgaa ccgcctgccg atggcaatcc      840

atgaccagca gcaatgaagt tatgggccag cgataccgcg ccgccatggc caagatgtct      900

gttctcggct tcgacaggaa cgccctcacc gattgctctg acgttattcc ttctgctgtg      960

tccaacaacg ctgctcctgt tatccctggt ggccttactg tcgatgatat cgaggtttcg     1020

tgcccgagcg agcctttccc tgaaattgct accgcctcag gccctctccc ctccctcgct     1080

cctgctcct                                                             1089


<210>  10
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIP H55W

<400>  10

Gln Gly Pro Gly Gly Gly Gly Ser Val Thr Cys Pro Gly Gly Gln Ser 
1               5                   10                  15      


Thr Ser Asn Ser Gln Cys Cys Val Trp Phe Asp Val Leu Asp Asp Leu 
            20                  25                  30          


Gln Thr Asn Phe Tyr Gln Gly Ser Lys Cys Glu Ser Pro Val Arg Lys 
        35                  40                  45              


Ile Leu Arg Ile Val Phe Trp Asp Ala Ile Gly Phe Ser Pro Ala Leu 
    50                  55                  60                  


Thr Ala Ala Gly Gln Phe Gly Gly Gly Gly Ala Asp Gly Ser Ile Ile 
65                  70                  75                  80  


Ala His Ser Asn Ile Glu Leu Ala Phe Pro Ala Asn Gly Gly Leu Thr 
                85                  90                  95      


Asp Thr Val Glu Ala Leu Arg Ala Val Gly Ile Asn His Gly Val Ser 
            100                 105                 110         


Phe Gly Asp Leu Ile Gln Phe Ala Thr Ala Val Gly Met Ser Asn Cys 
        115                 120                 125             


Pro Gly Ser Pro Arg Leu Glu Phe Leu Thr Gly Arg Ser Asn Ser Ser 
    130                 135                 140                 


Gln Pro Ser Pro Pro Ser Leu Ile Pro Gly Pro Gly Asn Thr Val Thr 
145                 150                 155                 160 


Ala Ile Leu Asp Arg Met Gly Asp Ala Gly Phe Ser Pro Asp Glu Val 
                165                 170                 175     


Val Asp Leu Leu Ala Ala His Ser Leu Ala Ser Gln Glu Gly Leu Asn 
            180                 185                 190         


Ser Ala Ile Phe Arg Ser Pro Leu Asp Ser Thr Pro Gln Val Phe Asp 
        195                 200                 205             


Thr Gln Phe Tyr Ile Glu Thr Leu Leu Lys Gly Thr Thr Gln Pro Gly 
    210                 215                 220                 


Pro Ser Leu Gly Phe Ala Glu Glu Leu Ser Pro Phe Pro Gly Glu Phe 
225                 230                 235                 240 


Arg Met Arg Ser Asp Ala Leu Leu Ala Arg Asp Ser Arg Thr Ala Cys 
                245                 250                 255     


Arg Trp Gln Ser Met Thr Ser Ser Asn Glu Val Met Gly Gln Arg Tyr 
            260                 265                 270         


Arg Ala Ala Met Ala Lys Met Ser Val Leu Gly Phe Asp Arg Asn Ala 
        275                 280                 285             


Leu Thr Asp Cys Ser Asp Val Ile Pro Ser Ala Val Ser Asn Asn Ala 
    290                 295                 300                 


Ala Pro Val Ile Pro Gly Gly Leu Thr Val Asp Asp Ile Glu Val Ser 
305                 310                 315                 320 


Cys Pro Ser Glu Pro Phe Pro Glu Ile Ala Thr Ala Ser Gly Pro Leu 
                325                 330                 335     


Pro Ser Leu Ala Pro Ala Pro 
            340             


<210>  11
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT392 I98W

<400>  11
atgatttcga cctcgaagca tctcttcgtc ttgctcccgc tcttcttggt ctcgcatctc       60

tcgctcgtcc tcggtttccc tgcatacgcc tccttgggag gcttgaccga acgtcaggtg      120

gaggagtata cgtcgaagtt gcctatcgtg ttccctcctc ctcctccgga acctatcaaa      180

gatccttggc tcaagctcgt gaacgatagg gcacacccct ggaggccttt gaggcgaggc      240

gacgtgcgag gaccctgtcc cggtctcaac accctcgcat cccatggcta tttgcctcgc      300

gacggcgtcg ccacaccggc acagatcatc acagcggtcc aggaaggctt caacatggaa      360

tacggctggg ccacattcgt cacctatgca gcccacctcg tggacggaaa cccgctcacc      420

aacttgatct ccattggagg caagacccgg aaaactggtc cggaccctcc tcctcctgcg      480

atcgtgggag gattgaacac acatgcggtc ttcgagggcg acgcgtccat gacacgaggc      540

gatttccatt tgggtgacaa cttcaacttc aaccagactc tctgggagca gttcaaggat      600

tactcgaacc gctatggtgg aggaaggtat aacctcactg cagcagccga gttgcgttgg      660

gcacgaatcc agcagtccat ggcaaccaac ggacagttcg acttcacctc gcccaggtac      720

ttcacagcct atgccgaatc cgtgttccct atcaacttct tcaccgacgg acgattgttc      780

acctcgaaca ccactgcacc tggacccgac atggattcgg cgttgtcgtt cttccgagac      840

cacaggtatc cgaaagattt ccatcgagcg cctgtccctt cgggtgcacg gggattggac      900

gtcgtcgcag cagcgtaccc cattcagcct ggctacaacg ccgatggcaa ggtcaacaac      960

tatgtcttgg accccacgtc cgcagatttc accaagttct gtctcttgta cgagaacttc     1020

gtgttgaaga ccgtcaaggg tttgtacccc aaccctaagg gcttcctcag gaaggcgttg     1080

gagacaaact tggagtattt ctaccagtcc ttccctggct ccggtggctg tccccaggtg     1140

ttcccctggg gtaagtcgga t                                               1161


<210>  12
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT392 I98W

<400>  12

Phe Pro Ala Tyr Ala Ser Leu Gly Gly Leu Thr Glu Arg Gln Val Glu 
1               5                   10                  15      


Glu Tyr Thr Ser Lys Leu Pro Ile Val Phe Pro Pro Pro Pro Pro Glu 
            20                  25                  30          


Pro Ile Lys Asp Pro Trp Leu Lys Leu Val Asn Asp Arg Ala His Pro 
        35                  40                  45              


Trp Arg Pro Leu Arg Arg Gly Asp Val Arg Gly Pro Cys Pro Gly Leu 
    50                  55                  60                  


Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asp Gly Val Ala Thr 
65                  70                  75                  80  


Pro Ala Gln Ile Ile Thr Ala Val Gln Glu Gly Phe Asn Met Glu Tyr 
                85                  90                  95      


Gly Trp Ala Thr Phe Val Thr Tyr Ala Ala His Leu Val Asp Gly Asn 
            100                 105                 110         


Pro Leu Thr Asn Leu Ile Ser Ile Gly Gly Lys Thr Arg Lys Thr Gly 
        115                 120                 125             


Pro Asp Pro Pro Pro Pro Ala Ile Val Gly Gly Leu Asn Thr His Ala 
    130                 135                 140                 


Val Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Phe His Leu Gly 
145                 150                 155                 160 


Asp Asn Phe Asn Phe Asn Gln Thr Leu Trp Glu Gln Phe Lys Asp Tyr 
                165                 170                 175     


Ser Asn Arg Tyr Gly Gly Gly Arg Tyr Asn Leu Thr Ala Ala Ala Glu 
            180                 185                 190         


Leu Arg Trp Ala Arg Ile Gln Gln Ser Met Ala Thr Asn Gly Gln Phe 
        195                 200                 205             


Asp Phe Thr Ser Pro Arg Tyr Phe Thr Ala Tyr Ala Glu Ser Val Phe 
    210                 215                 220                 


Pro Ile Asn Phe Phe Thr Asp Gly Arg Leu Phe Thr Ser Asn Thr Thr 
225                 230                 235                 240 


Ala Pro Gly Pro Asp Met Asp Ser Ala Leu Ser Phe Phe Arg Asp His 
                245                 250                 255     


Arg Tyr Pro Lys Asp Phe His Arg Ala Pro Val Pro Ser Gly Ala Arg 
            260                 265                 270         


Gly Leu Asp Val Val Ala Ala Ala Tyr Pro Ile Gln Pro Gly Tyr Asn 
        275                 280                 285             


Ala Asp Gly Lys Val Asn Asn Tyr Val Leu Asp Pro Thr Ser Ala Asp 
    290                 295                 300                 


Phe Thr Lys Phe Cys Leu Leu Tyr Glu Asn Phe Val Leu Lys Thr Val 
305                 310                 315                 320 


Lys Gly Leu Tyr Pro Asn Pro Lys Gly Phe Leu Arg Lys Ala Leu Glu 
                325                 330                 335     


Thr Asn Leu Glu Tyr Phe Tyr Gln Ser Phe Pro Gly Ser Gly Gly Cys 
            340                 345                 350         


Pro Gln Val Phe Pro Trp Gly Lys Ser Asp 
        355                 360         


<210>  13
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT392 V102L

<400>  13
atgatttcga cctcgaagca tctcttcgtc ttgctcccgc tcttcttggt ctcgcatctc       60

tcgctcgtcc tcggtttccc tgcatacgcc tccttgggag gcttgaccga acgtcaggtg      120

gaggagtata cgtcgaagtt gcctatcgtg ttccctcctc ctcctccgga acctatcaaa      180

gatccttggc tcaagctcgt gaacgatagg gcacacccct ggaggccttt gaggcgaggc      240

gacgtgcgag gaccctgtcc cggtctcaac accctcgcat cccatggcta tttgcctcgc      300

gacggcgtcg ccacaccggc acagatcatc acagcggtcc aggaaggctt caacatggaa      360

tacggcatcg ccacattctt gacctatgca gcccacctcg tggacggaaa cccgctcacc      420

aacttgatct ccattggagg caagacccgg aaaactggtc cggaccctcc tcctcctgcg      480

atcgtgggag gattgaacac acatgcggtc ttcgagggcg acgcgtccat gacacgaggc      540

gatttccatt tgggtgacaa cttcaacttc aaccagactc tctgggagca gttcaaggat      600

tactcgaacc gctatggtgg aggaaggtat aacctcactg cagcagccga gttgcgttgg      660

gcacgaatcc agcagtccat ggcaaccaac ggacagttcg acttcacctc gcccaggtac      720

ttcacagcct atgccgaatc cgtgttccct atcaacttct tcaccgacgg acgattgttc      780

acctcgaaca ccactgcacc tggacccgac atggattcgg cgttgtcgtt cttccgagac      840

cacaggtatc cgaaagattt ccatcgagcg cctgtccctt cgggtgcacg gggattggac      900

gtcgtcgcag cagcgtaccc cattcagcct ggctacaacg ccgatggcaa ggtcaacaac      960

tatgtcttgg accccacgtc cgcagatttc accaagttct gtctcttgta cgagaacttc     1020

gtgttgaaga ccgtcaaggg tttgtacccc aaccctaagg gcttcctcag gaaggcgttg     1080

gagacaaact tggagtattt ctaccagtcc ttccctggct ccggtggctg tccccaggtg     1140

ttcccctggg gtaagtcgga t                                               1161


<210>  14
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT392 V102L

<400>  14

Phe Pro Ala Tyr Ala Ser Leu Gly Gly Leu Thr Glu Arg Gln Val Glu 
1               5                   10                  15      


Glu Tyr Thr Ser Lys Leu Pro Ile Val Phe Pro Pro Pro Pro Pro Glu 
            20                  25                  30          


Pro Ile Lys Asp Pro Trp Leu Lys Leu Val Asn Asp Arg Ala His Pro 
        35                  40                  45              


Trp Arg Pro Leu Arg Arg Gly Asp Val Arg Gly Pro Cys Pro Gly Leu 
    50                  55                  60                  


Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asp Gly Val Ala Thr 
65                  70                  75                  80  


Pro Ala Gln Ile Ile Thr Ala Val Gln Glu Gly Phe Asn Met Glu Tyr 
                85                  90                  95      


Gly Ile Ala Thr Phe Leu Thr Tyr Ala Ala His Leu Val Asp Gly Asn 
            100                 105                 110         


Pro Leu Thr Asn Leu Ile Ser Ile Gly Gly Lys Thr Arg Lys Thr Gly 
        115                 120                 125             


Pro Asp Pro Pro Pro Pro Ala Ile Val Gly Gly Leu Asn Thr His Ala 
    130                 135                 140                 


Val Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Phe His Leu Gly 
145                 150                 155                 160 


Asp Asn Phe Asn Phe Asn Gln Thr Leu Trp Glu Gln Phe Lys Asp Tyr 
                165                 170                 175     


Ser Asn Arg Tyr Gly Gly Gly Arg Tyr Asn Leu Thr Ala Ala Ala Glu 
            180                 185                 190         


Leu Arg Trp Ala Arg Ile Gln Gln Ser Met Ala Thr Asn Gly Gln Phe 
        195                 200                 205             


Asp Phe Thr Ser Pro Arg Tyr Phe Thr Ala Tyr Ala Glu Ser Val Phe 
    210                 215                 220                 


Pro Ile Asn Phe Phe Thr Asp Gly Arg Leu Phe Thr Ser Asn Thr Thr 
225                 230                 235                 240 


Ala Pro Gly Pro Asp Met Asp Ser Ala Leu Ser Phe Phe Arg Asp His 
                245                 250                 255     


Arg Tyr Pro Lys Asp Phe His Arg Ala Pro Val Pro Ser Gly Ala Arg 
            260                 265                 270         


Gly Leu Asp Val Val Ala Ala Ala Tyr Pro Ile Gln Pro Gly Tyr Asn 
        275                 280                 285             


Ala Asp Gly Lys Val Asn Asn Tyr Val Leu Asp Pro Thr Ser Ala Asp 
    290                 295                 300                 


Phe Thr Lys Phe Cys Leu Leu Tyr Glu Asn Phe Val Leu Lys Thr Val 
305                 310                 315                 320 


Lys Gly Leu Tyr Pro Asn Pro Lys Gly Phe Leu Arg Lys Ala Leu Glu 
                325                 330                 335     


Thr Asn Leu Glu Tyr Phe Tyr Gln Ser Phe Pro Gly Ser Gly Gly Cys 
            340                 345                 350         


Pro Gln Val Phe Pro Trp Gly Lys Ser Asp 
        355                 360         


<210>  15
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT392 V102W

<400>  15
atgatttcga cctcgaagca tctcttcgtc ttgctcccgc tcttcttggt ctcgcatctc       60

tcgctcgtcc tcggtttccc tgcatacgcc tccttgggag gcttgaccga acgtcaggtg      120

gaggagtata cgtcgaagtt gcctatcgtg ttccctcctc ctcctccgga acctatcaaa      180

gatccttggc tcaagctcgt gaacgatagg gcacacccct ggaggccttt gaggcgaggc      240

gacgtgcgag gaccctgtcc cggtctcaac accctcgcat cccatggcta tttgcctcgc      300

gacggcgtcg ccacaccggc acagatcatc acagcggtcc aggaaggctt caacatggaa      360

tacggcatcg ccacattctg gacctatgca gcccacctcg tggacggaaa cccgctcacc      420

aacttgatct ccattggagg caagacccgg aaaactggtc cggaccctcc tcctcctgcg      480

atcgtgggag gattgaacac acatgcggtc ttcgagggcg acgcgtccat gacacgaggc      540

gatttccatt tgggtgacaa cttcaacttc aaccagactc tctgggagca gttcaaggat      600

tactcgaacc gctatggtgg gggaaggtat aacctcactg cagcagccga gttgcgttgg      660

gcacgaatcc agcagtccat ggcaaccaac ggacagttcg acttcacctc gcccaggtac      720

ttcacagcct atgccgaatc cgtgttccct atcaacttct tcaccgacgg acgattgttc      780

acctcgaaca ccactgcacc tggacccgac atggattcgg cgttgtcgtt cttccgagac      840

cacaggtatc cgaaagattt ccatcgagcg cctgtccctt cgggtgcacg gggattggac      900

gtcgtcgcag cagcgtaccc cattcagcct ggctacaacg ccgatggcaa ggtcaacaac      960

tatgtcttgg accccacgtc cgcagatttc accaagttct gtctcttgta cgagaacttc     1020

gtgttgaaga ccgtcaaggg tttgtacccc aaccctaagg gcttcctcag gaaggcgttg     1080

gagacaaact tggagtattt ctaccagtcc ttccctggct ccggtggctg tccccaggtg     1140

ttcccctggg gtaagtcgga t                                               1161


<210>  16
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT392 V102W

<400>  16

Phe Pro Ala Tyr Ala Ser Leu Gly Gly Leu Thr Glu Arg Gln Val Glu 
1               5                   10                  15      


Glu Tyr Thr Ser Lys Leu Pro Ile Val Phe Pro Pro Pro Pro Pro Glu 
            20                  25                  30          


Pro Ile Lys Asp Pro Trp Leu Lys Leu Val Asn Asp Arg Ala His Pro 
        35                  40                  45              


Trp Arg Pro Leu Arg Arg Gly Asp Val Arg Gly Pro Cys Pro Gly Leu 
    50                  55                  60                  


Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asp Gly Val Ala Thr 
65                  70                  75                  80  


Pro Ala Gln Ile Ile Thr Ala Val Gln Glu Gly Phe Asn Met Glu Tyr 
                85                  90                  95      


Gly Ile Ala Thr Phe Trp Thr Tyr Ala Ala His Leu Val Asp Gly Asn 
            100                 105                 110         


Pro Leu Thr Asn Leu Ile Ser Ile Gly Gly Lys Thr Arg Lys Thr Gly 
        115                 120                 125             


Pro Asp Pro Pro Pro Pro Ala Ile Val Gly Gly Leu Asn Thr His Ala 
    130                 135                 140                 


Val Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Phe His Leu Gly 
145                 150                 155                 160 


Asp Asn Phe Asn Phe Asn Gln Thr Leu Trp Glu Gln Phe Lys Asp Tyr 
                165                 170                 175     


Ser Asn Arg Tyr Gly Gly Gly Arg Tyr Asn Leu Thr Ala Ala Ala Glu 
            180                 185                 190         


Leu Arg Trp Ala Arg Ile Gln Gln Ser Met Ala Thr Asn Gly Gln Phe 
        195                 200                 205             


Asp Phe Thr Ser Pro Arg Tyr Phe Thr Ala Tyr Ala Glu Ser Val Phe 
    210                 215                 220                 


Pro Ile Asn Phe Phe Thr Asp Gly Arg Leu Phe Thr Ser Asn Thr Thr 
225                 230                 235                 240 


Ala Pro Gly Pro Asp Met Asp Ser Ala Leu Ser Phe Phe Arg Asp His 
                245                 250                 255     


Arg Tyr Pro Lys Asp Phe His Arg Ala Pro Val Pro Ser Gly Ala Arg 
            260                 265                 270         


Gly Leu Asp Val Val Ala Ala Ala Tyr Pro Ile Gln Pro Gly Tyr Asn 
        275                 280                 285             


Ala Asp Gly Lys Val Asn Asn Tyr Val Leu Asp Pro Thr Ser Ala Asp 
    290                 295                 300                 


Phe Thr Lys Phe Cys Leu Leu Tyr Glu Asn Phe Val Leu Lys Thr Val 
305                 310                 315                 320 


Lys Gly Leu Tyr Pro Asn Pro Lys Gly Phe Leu Arg Lys Ala Leu Glu 
                325                 330                 335     


Thr Asn Leu Glu Tyr Phe Tyr Gln Ser Phe Pro Gly Ser Gly Gly Cys 
            340                 345                 350         


Pro Gln Val Phe Pro Trp Gly Lys Ser Asp 
        355                 360         


<210>  17
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT392 F224W

<400>  17
atgatttcga cctcgaagca tctcttcgtc ttgctcccgc tcttcttggt ctcgcatctc       60

tcgctcgtcc tcggtttccc tgcatacgcc tccttgggag gcttgaccga acgtcaggtg      120

gaggagtata cgtcgaagtt gcctatcgtg ttccctcctc ctcctccgga acctatcaaa      180

gatccttggc tcaagctcgt gaacgatagg gcacacccct ggaggccttt gaggcgaggc      240

gacgtgcgag gaccctgtcc cggtctcaac accctcgcat cccatggcta tttgcctcgc      300

gacggcgtcg ccacaccggc acagatcatc acagcggtcc aggaaggctt caacatggaa      360

tacggcatcg ccacattcgt cacctatgca gcccacctcg tggacggaaa cccgctcacc      420

aacttgatct ccattggagg caagacccgg aaaactggtc cggaccctcc tcctcctgcg      480

atcgtgggag gattgaacac acatgcggtc ttcgagggcg acgcgtccat gacacgaggc      540

gatttccatt tgggtgacaa cttcaacttc aaccagactc tctgggagca gttcaaggat      600

tactcgaacc gctatggtgg aggaaggtat aacctcactg cagcagccga gttgcgttgg      660

gcacgaatcc agcagtccat ggcaaccaac ggacagttcg acttcacctc gcccaggtac      720

ttcacagcct atgccgaatc cgtgtggcct atcaacttct tcaccgacgg acgattgttc      780

acctcgaaca ccactgcacc tggacccgac atggattcgg cgttgtcgtt cttccgagac      840

cacaggtatc cgaaagattt ccatcgagcg cctgtccctt cgggtgcacg gggattggac      900

gtcgtcgcag cagcgtaccc cattcagcct ggctacaacg ccgatggcaa ggtcaacaac      960

tatgtcttgg accccacgtc cgcagatttc accaagttct gtctcttgta cgagaacttc     1020

gtgttgaaga ccgtcaaggg tttgtacccc aaccctaagg gcttcctcag gaaggcgttg     1080

gagacaaact tggagtattt ctaccagtcc ttccctggct ccggtggctg tccccaggtg     1140

ttcccctggg gtaagtcgga t                                               1161


<210>  18
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT392 F224W

<400>  18

Phe Pro Ala Tyr Ala Ser Leu Gly Gly Leu Thr Glu Arg Gln Val Glu 
1               5                   10                  15      


Glu Tyr Thr Ser Lys Leu Pro Ile Val Phe Pro Pro Pro Pro Pro Glu 
            20                  25                  30          


Pro Ile Lys Asp Pro Trp Leu Lys Leu Val Asn Asp Arg Ala His Pro 
        35                  40                  45              


Trp Arg Pro Leu Arg Arg Gly Asp Val Arg Gly Pro Cys Pro Gly Leu 
    50                  55                  60                  


Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asp Gly Val Ala Thr 
65                  70                  75                  80  


Pro Ala Gln Ile Ile Thr Ala Val Gln Glu Gly Phe Asn Met Glu Tyr 
                85                  90                  95      


Gly Ile Ala Thr Phe Val Thr Tyr Ala Ala His Leu Val Asp Gly Asn 
            100                 105                 110         


Pro Leu Thr Asn Leu Ile Ser Ile Gly Gly Lys Thr Arg Lys Thr Gly 
        115                 120                 125             


Pro Asp Pro Pro Pro Pro Ala Ile Val Gly Gly Leu Asn Thr His Ala 
    130                 135                 140                 


Val Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Phe His Leu Gly 
145                 150                 155                 160 


Asp Asn Phe Asn Phe Asn Gln Thr Leu Trp Glu Gln Phe Lys Asp Tyr 
                165                 170                 175     


Ser Asn Arg Tyr Gly Gly Gly Arg Tyr Asn Leu Thr Ala Ala Ala Glu 
            180                 185                 190         


Leu Arg Trp Ala Arg Ile Gln Gln Ser Met Ala Thr Asn Gly Gln Phe 
        195                 200                 205             


Asp Phe Thr Ser Pro Arg Tyr Phe Thr Ala Tyr Ala Glu Ser Val Trp 
    210                 215                 220                 


Pro Ile Asn Phe Phe Thr Asp Gly Arg Leu Phe Thr Ser Asn Thr Thr 
225                 230                 235                 240 


Ala Pro Gly Pro Asp Met Asp Ser Ala Leu Ser Phe Phe Arg Asp His 
                245                 250                 255     


Arg Tyr Pro Lys Asp Phe His Arg Ala Pro Val Pro Ser Gly Ala Arg 
            260                 265                 270         


Gly Leu Asp Val Val Ala Ala Ala Tyr Pro Ile Gln Pro Gly Tyr Asn 
        275                 280                 285             


Ala Asp Gly Lys Val Asn Asn Tyr Val Leu Asp Pro Thr Ser Ala Asp 
    290                 295                 300                 


Phe Thr Lys Phe Cys Leu Leu Tyr Glu Asn Phe Val Leu Lys Thr Val 
305                 310                 315                 320 


Lys Gly Leu Tyr Pro Asn Pro Lys Gly Phe Leu Arg Lys Ala Leu Glu 
                325                 330                 335     


Thr Asn Leu Glu Tyr Phe Tyr Gln Ser Phe Pro Gly Ser Gly Gly Cys 
            340                 345                 350         


Pro Gln Val Phe Pro Trp Gly Lys Ser Asp 
        355                 360         


<210>  19
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 C17H

<400>  19
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgcatc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacatc ttcacttacg gtgagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  20
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 C17H

<400>  20

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


His Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Gly Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  21
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 I154L

<400>  21
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacctc ttcacttacg gtgagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  22
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 I154L

<400>  22

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Leu Phe Thr Tyr Gly Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  23
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 L151C

<400>  23
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagtg tggcaacatc ttcacttacg gtgagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  24
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 L151C

<400>  24

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Cys Gly Asn Ile Phe Thr Tyr Gly Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  25
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 G158C

<400>  25
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacatc ttcacttact gtgagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  26
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 G158C

<400>  26

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Cys Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  27
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 G158W

<400>  27
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacatc ttcacttact gggagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  28
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 G158W

<400>  28

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Trp Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  29
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 G158S

<400>  29
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacatc ttcacttact cggagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  30
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 G158S

<400>  30

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Ser Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  31
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 G158A

<400>  31
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacatc ttcacttacg ccgagtcggt cgcctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  32
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 G158A

<400>  32

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Ala Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  33
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Per27 A162L

<400>  33
atgatgatgc aatttaccac catcctctcc atcggtatca ccgtcttcgg actgggtatg       60

tacaccaccc ccttgcgtct gttatctgtg acatatgtag ctgactggtc agccaacacc      120

ggagcctttg cagcacccca gccggtaccc gaggcttacg ctgtttctga tcccgaggct      180

catcctgacg attttgctgg tatggatgcg aaccaacttc agaaacgtgg cttccatgat      240

tgggaacctc ccggtcctaa agacgtgcga gcaccgtgtc cgatgctcaa cacgttggcc      300

aaccacggct tcctccctca ccatggacgg gatttgacga ggaagcaggt ggtcgacggc      360

ctctacaacg gattgaacat caacaagact gccgcatccg cgttgttcga tttcgcactc      420

atgacatcgc ccaagccgaa cgcaacaacc ttctccctca acgacttggg caggcataac      480

atcttggagc acgacgcctc gctctcgcgc accgacgcct acttcggtga tgtgctcgcc      540

ttcaacaaaa ccatcttcga ggagaccaag aggcactggg gaaaatcgcc catcctcgat      600

gtcaccgcag cagccagggc aaggctcggt cggattcaga cgtccaaggc gaccaacccc      660

gagtatttca tgtcggagct cggcaacatc ttcacttacg gtgagtcggt cctctacatc      720

atgttgattg gagacgcgaa gaccggaaaa gccaacaggc gctgggtcga gtattggttc      780

gagaacgagc gcctccctac gcatttggga tggaggcgac cgtccaaaga gctcacatcg      840

gacgtcctcg atgcctacat ctcgctcatc cagaacatca cgctcacgct ccctggcgga      900

accgaccctg tgaaacgaag ggcagcgtcc catttcggct gg                         942


<210>  34
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Per27 A162L

<400>  34

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Gly Glu Ser 
145                 150                 155                 160 


Val Leu Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


<210>  35
<211>  343
<212>  PRT
<213>  Coprinus cinereus

<400>  35

Gln Gly Pro Gly Gly Gly Gly Ser Val Thr Cys Pro Gly Gly Gln Ser 
1               5                   10                  15      


Thr Ser Asn Ser Gln Cys Cys Val Trp Phe Asp Val Leu Asp Asp Leu 
            20                  25                  30          


Gln Thr Asn Phe Tyr Gln Gly Ser Lys Cys Glu Ser Pro Val Arg Lys 
        35                  40                  45              


Ile Leu Arg Ile Val Phe His Asp Ala Ile Gly Phe Ser Pro Ala Leu 
    50                  55                  60                  


Thr Ala Ala Gly Gln Phe Gly Gly Gly Gly Ala Asp Gly Ser Ile Ile 
65                  70                  75                  80  


Ala His Ser Asn Ile Glu Leu Ala Phe Pro Ala Asn Gly Gly Leu Thr 
                85                  90                  95      


Asp Thr Val Glu Ala Leu Arg Ala Val Gly Ile Asn His Gly Val Ser 
            100                 105                 110         


Phe Gly Asp Leu Ile Gln Phe Ala Thr Ala Val Gly Met Ser Asn Cys 
        115                 120                 125             


Pro Gly Ser Pro Arg Leu Glu Phe Leu Thr Gly Arg Ser Asn Ser Ser 
    130                 135                 140                 


Gln Pro Ser Pro Pro Ser Leu Ile Pro Gly Pro Gly Asn Thr Val Thr 
145                 150                 155                 160 


Ala Ile Leu Asp Arg Met Gly Asp Ala Gly Phe Ser Pro Asp Glu Val 
                165                 170                 175     


Val Asp Leu Leu Ala Ala His Ser Leu Ala Ser Gln Glu Gly Leu Asn 
            180                 185                 190         


Ser Ala Ile Phe Arg Ser Pro Leu Asp Ser Thr Pro Gln Val Phe Asp 
        195                 200                 205             


Thr Gln Phe Tyr Ile Glu Thr Leu Leu Lys Gly Thr Thr Gln Pro Gly 
    210                 215                 220                 


Pro Ser Leu Gly Phe Ala Glu Glu Leu Ser Pro Phe Pro Gly Glu Phe 
225                 230                 235                 240 


Arg Met Arg Ser Asp Ala Leu Leu Ala Arg Asp Ser Arg Thr Ala Cys 
                245                 250                 255     


Arg Trp Gln Ser Met Thr Ser Ser Asn Glu Val Met Gly Gln Arg Tyr 
            260                 265                 270         


Arg Ala Ala Met Ala Lys Met Ser Val Leu Gly Phe Asp Arg Asn Ala 
        275                 280                 285             


Leu Thr Asp Cys Ser Asp Val Ile Pro Ser Ala Val Ser Asn Asn Ala 
    290                 295                 300                 


Ala Pro Val Ile Pro Gly Gly Leu Thr Val Asp Asp Ile Glu Val Ser 
305                 310                 315                 320 


Cys Pro Ser Glu Pro Phe Pro Glu Ile Ala Thr Ala Ser Gly Pro Leu 
                325                 330                 335     


Pro Ser Leu Ala Pro Ala Pro 
            340             


<210>  36
<211>  362
<212>  PRT
<213>  Coprinus cinereus

<400>  36

Phe Pro Ala Tyr Ala Ser Leu Gly Gly Leu Thr Glu Arg Gln Val Glu 
1               5                   10                  15      


Glu Tyr Thr Ser Lys Leu Pro Ile Val Phe Pro Pro Pro Pro Pro Glu 
            20                  25                  30          


Pro Ile Lys Asp Pro Trp Leu Lys Leu Val Asn Asp Arg Ala His Pro 
        35                  40                  45              


Trp Arg Pro Leu Arg Arg Gly Asp Val Arg Gly Pro Cys Pro Gly Leu 
    50                  55                  60                  


Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asp Gly Val Ala Thr 
65                  70                  75                  80  


Pro Ala Gln Ile Ile Thr Ala Val Gln Glu Gly Phe Asn Met Glu Tyr 
                85                  90                  95      


Gly Ile Ala Thr Phe Val Thr Tyr Ala Ala His Leu Val Asp Gly Asn 
            100                 105                 110         


Pro Leu Thr Asn Leu Ile Ser Ile Gly Gly Lys Thr Arg Lys Thr Gly 
        115                 120                 125             


Pro Asp Pro Pro Pro Pro Ala Ile Val Gly Gly Leu Asn Thr His Ala 
    130                 135                 140                 


Val Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Phe His Leu Gly 
145                 150                 155                 160 


Asp Asn Phe Asn Phe Asn Gln Thr Leu Trp Glu Gln Phe Lys Asp Tyr 
                165                 170                 175     


Ser Asn Arg Tyr Gly Gly Gly Arg Tyr Asn Leu Thr Ala Ala Ala Glu 
            180                 185                 190         


Leu Arg Trp Ala Arg Ile Gln Gln Ser Met Ala Thr Asn Gly Gln Phe 
        195                 200                 205             


Asp Phe Thr Ser Pro Arg Tyr Phe Thr Ala Tyr Ala Glu Ser Val Phe 
    210                 215                 220                 


Pro Ile Asn Phe Phe Thr Asp Gly Arg Leu Phe Thr Ser Asn Thr Thr 
225                 230                 235                 240 


Ala Pro Gly Pro Asp Met Asp Ser Ala Leu Ser Phe Phe Arg Asp His 
                245                 250                 255     


Arg Tyr Pro Lys Asp Phe His Arg Ala Pro Val Pro Ser Gly Ala Arg 
            260                 265                 270         


Gly Leu Asp Val Val Ala Ala Ala Tyr Pro Ile Gln Pro Gly Tyr Asn 
        275                 280                 285             


Ala Asp Gly Lys Val Asn Asn Tyr Val Leu Asp Pro Thr Ser Ala Asp 
    290                 295                 300                 


Phe Thr Lys Phe Cys Leu Leu Tyr Glu Asn Phe Val Leu Lys Thr Val 
305                 310                 315                 320 


Lys Gly Leu Tyr Pro Asn Pro Lys Gly Phe Leu Arg Lys Ala Leu Glu 
                325                 330                 335     


Thr Asn Leu Glu Tyr Phe Tyr Gln Ser Phe Pro Gly Ser Gly Gly Cys 
            340                 345                 350         


Pro Gln Val Phe Pro Trp Gly Lys Ser Asp 
        355                 360         


<210>  37
<211>  238
<212>  PRT
<213>  Humicola insolens

<400>  37

Gly Phe His Asp Trp Glu Pro Pro Gly Pro Lys Asp Val Arg Ala Pro 
1               5                   10                  15      


Cys Pro Met Leu Asn Thr Leu Ala Asn His Gly Phe Leu Pro His His 
            20                  25                  30          


Gly Arg Asp Leu Thr Arg Lys Gln Val Val Asp Gly Leu Tyr Asn Gly 
        35                  40                  45              


Leu Asn Ile Asn Lys Thr Ala Ala Ser Ala Leu Phe Asp Phe Ala Leu 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro Asn Ala Thr Thr Phe Ser Leu Asn Asp Leu 
65                  70                  75                  80  


Gly Arg His Asn Ile Leu Glu His Asp Ala Ser Leu Ser Arg Thr Asp 
                85                  90                  95      


Ala Tyr Phe Gly Asp Val Leu Ala Phe Asn Lys Thr Ile Phe Glu Glu 
            100                 105                 110         


Thr Lys Arg His Trp Gly Lys Ser Pro Ile Leu Asp Val Thr Ala Ala 
        115                 120                 125             


Ala Arg Ala Arg Leu Gly Arg Ile Gln Thr Ser Lys Ala Thr Asn Pro 
    130                 135                 140                 


Glu Tyr Phe Met Ser Glu Leu Gly Asn Ile Phe Thr Tyr Gly Glu Ser 
145                 150                 155                 160 


Val Ala Tyr Ile Met Leu Ile Gly Asp Ala Lys Thr Gly Lys Ala Asn 
                165                 170                 175     


Arg Arg Trp Val Glu Tyr Trp Phe Glu Asn Glu Arg Leu Pro Thr His 
            180                 185                 190         


Leu Gly Trp Arg Arg Pro Ser Lys Glu Leu Thr Ser Asp Val Leu Asp 
        195                 200                 205             


Ala Tyr Ile Ser Leu Ile Gln Asn Ile Thr Leu Thr Leu Pro Gly Gly 
    210                 215                 220                 


Thr Asp Pro Val Lys Arg Arg Ala Ala Ser His Phe Gly Trp 
225                 230                 235             


