                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
 
<120>  Antibodies

<130>  N419971WO

<150>  GB 2102227.2 
<151>  2020-02-17

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - Light chain variable region

<400>  1

Ala Val Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Glu Gly Tyr Ser Ile His Val 
                85                  90                  95      


Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 


<210>  2
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW1

<400>  2

Ala Val Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Asn Cys 
            20              


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - CDR1

<400>  3

Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 
1               5                   10      


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW2

<400>  4

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - CDR2

<400>  5

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW3

<400>  6

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - CDR3

<400>  7

Gln Glu Gly Tyr Ser Ile His Val Asp Asn Val 
1               5                   10      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW4

<400>  8

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - Heavy chain variable region

<400>  9

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Thr Gly Asn Thr Phe Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Thr 
                85                  90                  95      


Asn Ser Asp Ser His Tyr Gly Trp Glu Ala Phe Asn Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW1

<400>  10

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser 
            20                  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - CDR1

<400>  11

Gly Ile Asp Leu Ser Asn Tyr Ala Met Ile 
1               5                   10  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW2

<400>  12

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - CDR2

<400>  13

Ile Ile Ser Ser Thr Gly Asn Thr Phe Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW3

<400>  14

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - CDR3

<400>  15

Asp Thr Asn Ser Asp Ser His Tyr Gly Trp Glu Ala Phe Asn Ile 
1               5                   10                  15  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - FW4

<400>  16

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  17
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7082 - derived scFv intrabody

<400>  17

Met Ala Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly 
1               5                   10                  15      


Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn 
            20                  25                  30          


Tyr Ala Met Ile Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Ile Ile Ser Ser Thr Gly Asn Thr Phe Tyr Ala Thr Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Asp Thr Asn Ser Asp Ser His Tyr Gly Trp Glu Ala Phe Asn Ile Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val 
    130                 135                 140                 


Val Leu Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly Gly Thr 
145                 150                 155                 160 


Val Ser Ile Asn Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr Arg 
            180                 185                 190         


Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys Ala Asp 
    210                 215                 220                 


Ala Ala Thr Tyr Tyr Cys Gln Glu Gly Tyr Ser Ile His Val Asp Asn 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
                245                 250     


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - Light chain variable region

<400>  18

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Pro Ser Val Leu Asn Thr 
            20                  25                  30          


Asn Asp Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Val 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Asp Val 
                85                  90                  95      


Asn Ile Asp Ile Tyr Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210>  19
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW1

<400>  19

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys 
            20              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - CDR1

<400>  20

Gln Ser Ser Pro Ser Val Leu Asn Thr Asn Asp Leu Ser 
1               5                   10              


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW2

<400>  21

Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr 
1               5                   10                  15  


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - CDR2

<400>  22

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW3

<400>  23

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - CDR3

<400>  24

Ala Gly Gly Tyr Asp Val Asn Ile Asp Ile Tyr Gly 
1               5                   10          


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW4

<400>  25

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - Heavy chain variable region

<400>  26

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Met Gly Thr Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Ser Met Thr 
65                  70                  75                  80  


Ser Leu Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ala 
                85                  90                  95      


Gly Ile Thr Tyr Ser Thr Tyr Tyr Phe Asn Ile Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  27
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW1

<400>  27

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser 
            20                  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - CDR1

<400>  28

Gly Phe Ser Leu Ser Asn Tyr Ala Met Ile 
1               5                   10  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW2

<400>  29

Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - CDR2

<400>  30

Thr Met Gly Thr Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW3

<400>  31

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Ser Met Thr 
1               5                   10                  15      


Ser Leu Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - CDR3

<400>  32

Asp Ala Gly Ile Thr Tyr Ser Thr Tyr Tyr Phe Asn Ile 
1               5                   10              


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - FW4

<400>  33

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  34
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VR7081 - derived scFv intrabody

<400>  34

Met Ala Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly 
1               5                   10                  15      


Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn 
            20                  25                  30          


Tyr Ala Met Ile Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Thr Met Gly Thr Asn Gly Arg Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Met Asp Leu Ser 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Asp Ala Gly Ile Thr Tyr Ser Thr Tyr Tyr Phe Asn Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Val Leu 
    130                 135                 140                 


Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly Gly Thr Val Ser 
145                 150                 155                 160 


Ile Ser Cys Gln Ser Ser Pro Ser Val Leu Asn Thr Asn Asp Leu Ser 
                165                 170                 175     


Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr Gly 
            180                 185                 190         


Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln Cys Asp Asp 
    210                 215                 220                 


Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Asp Val Asn Ile Asp Ile 
225                 230                 235                 240 


Tyr Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
                245                 250         


<210>  35
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  35

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  36
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  36

His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro 
1               5                   10                  


<210>  37
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  37

Lys Asp Asn Ile Lys His Cys Pro Gly 
1               5                   


<210>  38
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  38

Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
                85                  90                  


<210>  39
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  39

Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        35                  40                  45              


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    50                  55                  60                  


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
65                  70                  75                  80  


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                85                  90                  95      


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            100                 105                 110         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
        115                 120                 125 


<210>  40
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2

<400>  40

Tyr Phe Cys Ala Arg Asp Thr Asn Ser Asp Ser His Tyr Gly Trp Glu 
1               5                   10                  15      


Ala Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Tyr 
            20                  25                  30          


Tyr Cys Gln Glu Gly Tyr Ser Ile His Val Asp Asn Val Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Lys Arg Thr 
    50                  55          


<210>  41
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 10

<400>  41

Tyr Phe Cys Ala Arg Ala Ala Asp Thr Ala Thr Ser Gly Tyr Asp Ile 
1               5                   10                  15      


Trp Arg Pro Gly Thr Leu Asp Thr Val Ser Ser Tyr Tyr Cys Gln Cys 
            20                  25                  30          


Thr Asp Tyr Gly Ser Thr Tyr Ile Gly Ala Phe Gly Gly Gly Thr Glu 
        35                  40                  45              


Val Val Val Ala Arg Thr 
    50                  


<210>  42
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 8

<400>  42

Tyr Phe Cys Ala Arg Val Arg Gly Asn Ser Arg Tyr Tyr Phe Met Asp 
1               5                   10                  15      


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Glu 
            20                  25                  30          


Ser Asn Tyr Trp Ser Phe Asn Thr Asn Tyr Gly Ala Pro Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Lys Arg Thr 
    50                  55          


<210>  43
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 5

<400>  43

Tyr Phe Cys Ala Arg Trp Thr Thr Lys Tyr Ala Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Ile Trp Ser Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Ala 
            20                  25                  30          


Gly Cys Lys Ser Thr Thr Ile Asp Ser Asn Thr Phe Gly Gly Gly Thr 
        35                  40                  45              


Glu Val Val Val Lys Arg Thr 
    50                  55  


<210>  44
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 4

<400>  44

Tyr Phe Cys Ala Arg Trp Thr Thr Lys Tyr Ala Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Ile Trp Arg Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Gln 
            20                  25                  30          


Ser Asn Tyr Trp Ser Phe Asn Thr Asn Tyr Gly Ala Pro Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Lys Arg Thr 
    50                  55          


<210>  45
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 9

<400>  45

Tyr Phe Cys Ala Arg Trp Thr Thr Lys Tyr Ala Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Ile Trp Ser Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Gln 
            20                  25                  30          


Ser Asn Tyr Trp Ser Phe Asn Thr Asn Tyr Gly Ala Pro Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Lys Arg Thr 
    50                  55          


<210>  46
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 1

<400>  46

Tyr Phe Cys Ala Arg Gly Thr Thr Lys Tyr Ala Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Gln 
            20                  25                  30          


Ser Asn Tyr Trp Ser Phe Asn Thr Asn Tyr Gly Ala Pro Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Arg Arg Thr 
    50                  55          


<210>  47
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 7

<400>  47

Tyr Phe Cys Ala Arg Gly Thr Thr Lys Tyr Ala Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Gln 
            20                  25                  30          


Ser Asn Tyr Trp Ser Phe Asn Thr Asn Tyr Gly Ala Pro Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Lys Arg Thr 
    50                  55          


<210>  48
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6

<400>  48

Tyr Phe Cys Ala Arg Gly Thr Thr Lys Tyr Ala Glu Asp Gly Tyr Asp 
1               5                   10                  15      


Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys Gln 
            20                  25                  30          


Ser Asn Tyr Gly Ser Phe Asn Thr Asn Tyr Gly Ala Pro Phe Gly Gly 
        35                  40                  45              


Gly Thr Glu Val Val Val Lys Arg Thr 
    50                  55          


<210>  49
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 11

<400>  49

Tyr Phe Cys Ala Arg Asp Ala Gly Ile Thr Tyr Ser Thr Tyr Tyr Phe 
1               5                   10                  15      


Asn Ile Gln Gly Pro Gly Thr Leu Val Thr Val Ser Ser Tyr Tyr Cys 
            20                  25                  30          


Ala Gly Asp Tyr Asp Val Asn Ile Asp Ile Tyr Gly Phe Gly Gly Gly 
        35                  40                  45              


Thr Glu Val Val Val Lys Arg Thr 
    50                  55      


<210>  50
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13

<400>  50

Tyr Phe Cys Ala Arg Gly Leu Glu Met Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Val Gly Asp Phe Ser Gly Trp Ile Phe 
            20                  25                  30          


Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
        35                  40                  45  


<210>  51
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12

<400>  51

Tyr Phe Cys Ala Arg Gly Leu Glu Met Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Leu Gly Gly Tyr Tyr Gly His Ile Tyr 
            20                  25                  30          


Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
        35                  40                  45  


<210>  52
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 15

<400>  52

Tyr Phe Cys Ala Arg Gly Leu Glu Ile Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Leu Gly Gly Tyr Ile Asp His Ile Tyr 
            20                  25                  30          


Val Phe Gly Gly Gly Thr Glu Val Val Val Val Arg Thr 
        35                  40                  45  


<210>  53
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 18

<400>  53

Tyr Phe Cys Ala Arg Gly Leu Glu Ile Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Leu Gly Gly Tyr Ser Gly His Ile Tyr 
            20                  25                  30          


Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
        35                  40                  45  


<210>  54
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 19

<400>  54

Tyr Phe Cys Ala Arg Asp Leu Glu Ile Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Leu Gly Gly Tyr Ser Gly His Ile Tyr 
            20                  25                  30          


Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
        35                  40                  45  


<210>  55
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 17

<400>  55

Tyr Phe Cys Gly Arg Gly Leu Glu Ile Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Leu Gly Gly Tyr Ser Gly His Ile Tyr 
            20                  25                  30          


Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
        35                  40                  45  


<210>  56
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16

<400>  56

Tyr Phe Cys Gly Arg Gly Leu Glu Ile Trp Gly Pro Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Tyr Tyr Cys Leu Gly Gly Tyr Leu Gly His Val Tyr 
            20                  25                  30          


Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
        35                  40                  45  


<210>  57
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  57

Lys Asp Glu Leu 
1               


<210>  58
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Glu Lys Asp Glu Leu 
1               5       


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  59

Gly Gly Gly Gly Ser 
1               5   


