                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD3 
       GENES

<130>  BHCD3EDG.003WO1

<140>  2021101895786
<141>  2021-02-19

<160>  66    

<170>  PatentIn version 3.3

<210>  1
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  1

Met Arg Trp Asn Thr Phe Trp Gly Ile Leu Cys Leu Ser Leu Leu Ala 
1               5                   10                  15      


Val Gly Thr Cys Gln Asp Asp Ala Glu Asn Ile Glu Tyr Lys Val Ser 
            20                  25                  30          


Ile Ser Gly Thr Ser Val Glu Leu Thr Cys Pro Leu Asp Ser Asp Glu 
        35                  40                  45              


Asn Leu Lys Trp Glu Lys Asn Gly Gln Glu Leu Pro Gln Lys His Asp 
    50                  55                  60                  


Lys His Leu Val Leu Gln Asp Phe Ser Glu Val Glu Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Cys Tyr Thr Pro Ala Ser Asn Lys Asn Thr Tyr Leu Tyr Leu 
                85                  90                  95      


Lys Ala Arg Val Cys Glu Tyr Cys Val Glu Val Asp Leu Thr Ala Val 
            100                 105                 110         


Ala Ile Ile Ile Ile Val Asp Ile Cys Ile Thr Leu Gly Leu Leu Met 
        115                 120                 125             


Val Ile Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val 
    130                 135                 140                 


Thr Arg Gly Thr Gly Ala Gly Ser Arg Pro Arg Gly Gln Asn Lys Glu 
145                 150                 155                 160 


Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly 
                165                 170                 175     


Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Ala Val 
            180                 185                 


<210>  2
<211>  207
<212>  PRT
<213>  Homo sapien

<400>  2

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  3
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  3

Met Glu His Ser Gly Ile Leu Ala Ser Leu Ile Leu Ile Ala Val Leu 
1               5                   10                  15      


Pro Gln Gly Ser Pro Phe Lys Ile Gln Val Thr Glu Tyr Glu Asp Lys 
            20                  25                  30          


Val Phe Val Thr Cys Asn Thr Ser Val Met His Leu Asp Gly Thr Val 
        35                  40                  45              


Glu Gly Trp Phe Ala Lys Asn Lys Thr Leu Asn Leu Gly Lys Gly Val 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Leu Cys Asn Gly Thr Glu Gln Leu Ala 
65                  70                  75                  80  


Lys Val Val Ser Ser Val Gln Val His Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      


Val Glu Leu Asp Ser Gly Thr Met Ala Gly Val Ile Phe Ile Asp Leu 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Tyr Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Pro Ser Gly Ala Ala Glu Val Gln Ala Leu Leu Lys 
    130                 135                 140                 


Asn Glu Gln Leu Tyr Gln Pro Leu Arg Asp Arg Glu Asp Thr Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Gly Asn Trp Pro Arg Asn Lys Lys Ser 
                165                 170             


<210>  4
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  5
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  5

Met Glu Gln Arg Lys Gly Leu Ala Gly Leu Phe Leu Val Ile Ser Leu 
1               5                   10                  15      


Leu Gln Gly Thr Val Ala Gln Thr Asn Lys Ala Lys Asn Leu Val Gln 
            20                  25                  30          


Val Asp Gly Ser Arg Gly Asp Gly Ser Val Leu Leu Thr Cys Gly Leu 
        35                  40                  45              


Thr Asp Lys Thr Ile Lys Trp Leu Lys Asp Gly Ser Ile Ile Ser Pro 
    50                  55                  60                  


Leu Asn Ala Thr Lys Asn Thr Trp Asn Leu Gly Asn Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Thr Tyr Gln Cys Gln Gly Ala Lys Glu Thr Ser Asn Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Glu Asn Cys Ile Glu Leu Asn Ile 
            100                 105                 110         


Gly Thr Ile Ser Gly Phe Ile Phe Ala Glu Val Ile Ser Ile Phe Phe 
        115                 120                 125             


Leu Ala Leu Gly Val Tyr Leu Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Gln Asn Glu Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Tyr Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Lys Lys 
            180         


<210>  6
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  7
<211>  4554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5 homology arm

<400>  7
accataaccc aacactagag ccagcttttc aataaaataa gacagtgtga aacaagttta     60

atattactca cacccaaaga tatttgaatc cctactgtgg tgattcgaat atgctcaggc    120

ccatgggaag tgtcactgtt aggaggtgtg gcattgttag agtgggcgtg gccttgatgg    180

agaaagtgcc tgactgtggg ggatgggctt taatgtccta tgctcaagct ccacctgggg    240

cagaagacag accctcctcc tggctgcctg cagaagacag tctcctgtta tttattgcct    300

ttggaccaag atgtacaact ctaggctctt ccagcaccat gtctgcctgg atgctgccat    360

gcttcacacg atggtgataa tggacttgaa cctctgaaac tgtaaaccag agccccagtg    420

aaatgttttc ttttataaga gttaccttgg ggggctggtg agatggctca gcaggtaaga    480

gcacccgact gctcttccaa aggtccggag ttcaaatccc agcaaccaca tggtggctca    540

caaccatccg taacgagatc tgactccctc ttctggagtg tctgaagaca gctacagtgt    600

acttacatat aataaataat aaatctttaa aaaaaaaaaa aagagttacc ttggtcatgg    660

tgtctcttca cagtaataaa accctaacta agacaccctc taaactgaat ccagtgacca    720

gaagtttccg agataaaaaa aaaaaaattc tgagcactgt ccatggaagc agccatggta    780

aacagcggca gaggttggca tctggaggtg acagggacaa caaaaacaaa accaataaac    840

acagaaagta caagagacag agacagtaaa aataaaacca aaaaacacag aaacagaaag    900

ctcacacact caatggagac aagtcagaaa caaaacatgt gctggctgcc atcattcata    960

cattcaatta aacctggtcc atttccatct tggttcccat gcttgcaaca aaacttctgc   1020

aaagacaaga cacaaaacca gaccaagaaa ctcaggttgg caggtgcaac atctcagttt   1080

tttgccttgg atgggagaat atttgggtcc tacagaatgc ctcctcaccc cagatgggat   1140

cccaacagaa ccagatgtcg cagaaaattc gttttcaggg gaggcctcca tagatgtttg   1200

ctgcttttct ccacatggta gttcactcta ctagtccagg aaactgaaag tacacttcga   1260

agccttggaa cttatcaaag ttgacacctc ctgaggtggc ccatcagccc cagagtccca   1320

gagtcagagg caggctttag aatttggatg agtggtctga tcttgctggg gcctcctgaa   1380

aacattaatc ctatcaagtg agaataagat cactaccaca aaatctgagc caaatctgaa   1440

gcaagcttta ttaaatactt aataaagcca ggttgatggg ttgtggtcag gtccataccc   1500

agtattctca gactatggtc ccaagttaca ttagtcaggg gcttataaaa gcaaaatcca   1560

cacaaggcta catccttcct acctttgtcc aatcaggagc aagcatacat cctgacataa   1620

ctgctaccta tagttttcac atctacacgt gattaagcat ctcctgtgca gttggggtaa   1680

ccatcttgtt taccaaagca aaatttcatg gcttattatc ttacgtgaac aacaagcccc   1740

cagcacttca ggaagttatc tgtccttgaa caattgggac ttacaggtta gcacagtaat   1800

ttaaatttaa aacataacat tagccttcac atgaccccca tatgtgcact atgaagtgtg   1860

tgatcgtgtg cccatgtaca cacactttta aaatatgaaa aaaagggggg aacaggatct   1920

ggaaagataa ggtcaggagt cacgagtact cgctgctctg tcagagtatt tgaatcctat   1980

tccagcgtcc atgtgaggcg cccataactg cctataactc gctccataga atctgaaacc   2040

ttcttctgcc tccttgggca cctacacaca tacaactcac acacacaaag atacaaataa   2100

aaaataaacc ttttgacaga tggtggtggt gcacaccttt aatcacagca ttcaggaggc   2160

agaggcaggt ggactgctga gttcaagacc atcctagtct acacagtgaa ttccaggata   2220

gccagggata tagaaagaaa ctctgtctca aaaaacacac acttgatggc tcacagccat   2280

ccttttgaga tctgatgtcc tcttctgggg tgtctgaaga cagctacagt gagcgagtgg   2340

gaagaaaaag tgtctgaagg cagctgcagt gtacataatg tattataaat ataataaata   2400

aataagtaaa tatataataa gtaatataat aaataaatct ttttaaaaaa caaaaaaatt   2460

aaattaaata ataagtcttt ttttaatgga aaaaatagag aagtaactct cccgaatgaa   2520

atatgaatac cacacccttg aacgttgatc tgggttgccc tgttccccta aggaaactgt   2580

gtgtagggag gtgtgctcac gtacggcttt aagtccagag caggacatca agtgtctccc   2640

tctctcattt accagctaat tgccttaaga cactattggg atccacctgc ctctgctttt   2700

caaatgggtg ctggggattt gaactcgggc tctcatgctt gcacacaaag tactgttatc   2760

caccaagccc ctggcagtca ttattattcc tttgtagtca taaaacaaac ccctaaatgc   2820

atgtattcac caaatgcatt ggtgggaaca gcaggtaggc aaattacaac aaagaatctc   2880

cagatttcag atccactctg gtgactttct tagcgttggg attggcggga gcttctggac   2940

cgtggatggc ccaagataac ggtggctcta gttctgcaac attccaactc tccccaacca   3000

cagagctcta atcggtcttc agattcttcc acacagatgc agcttcttca aggaatgtgt   3060

tcattcacaa agatagcagg ctgtagattc agtgggattc agaagacggg aaggttttag   3120

gagagcatgc gagtctaaag atctgaagag gagcccctcc catcttcagc tgaaaactaa   3180

gcatcaactt gaaaggatag ggagaaagct ttgcagctat cagggctgga aatagttgtt   3240

ccaactccac aatacaaggc actggaaaga gctggaggtt ataaggcaga agagataacc   3300

actcatttag aaacctcttt ggtaaaggca ctaatcccat ttgggagggt tctgtcctca   3360

agatctagcc tctcacagtg gatctgcctg ctaataccat caacatatga attaggagaa   3420

ggcaaagata aaataaagct gggtgtgaca gtacattcca gtaatctcgg tacttgggag   3480

ggaggggaag gaagatagcc aagagttcaa gaccagctta gaccttgtag caagttccaa   3540

accagccagg actatatagt gaaagcttgt ctcaaaaata aataaataga taatgagaga   3600

ggcaaaatga tgcaaatcca tgacagtacg acaacttgaa ggtcaataca tttcacagcc   3660

tagattaaac taatacattc cttgaataac atgataaaga aaatatttca gggcttctca   3720

catttttttt tctactcaag acacatgcct ttttgcctag gtaaatttta cacaacccta   3780

catataaagg tatacaaatc aactatttag cgatgataaa tcattacatt tctattttaa   3840

aacaatcttg gggaccagca ggatggctca gcttatgaag gcgtacactg ccaattctga   3900

agatagagtc ccccaaaacc cacatggcgg aaggaaagaa tcaactcttg caagctgtcc   3960

tctaacctcc acatgtgtgc gtggcacctg caaatatttt ttttaattac aaaaattaaa   4020

acaactattt ggggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttagca   4080

tttattacaa gtaaaagatg aggggctgga gacctgggtc agtgattaag agcacttact   4140

gctcctacac aggaactgag tttggttccc agcatcctct tcaagaaact cacaatcacc   4200

tataactcca gctctggggc aatctgacgt cttctcctgg cctctgacgg cattgcattc   4260

acatgcacaa acacacacac atacataatt taaaataaag ataaatcttt atttttagca   4320

tggaagatga atatgcttat ttatttctga ataaagaact aaatcttgac taaatatttt   4380

attcaaaggg catatagcac catcagtgtt tataagagtt gatcgatatt tttggctttt   4440

agggctgaaa atgtactcgg ttggtagagt gcttgcctag tatacatgag gtttgatcca   4500

caccattgca caagccagga atggtggtac gtgcttgtaa tcctaacact gtga         4554


<210>  8
<211>  5274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3 homology arm

<400>  8
tctatccaaa tagacatttc tttttttaat gtttgctggg ttcttacgca ggtcataatt     60

cagtgggcca gtgcagcagt gaggtggcac atcaagaaaa agtatctgcc acacaaatgt    120

gacaacctga gcccaatccc ctgagaagca gaaaaagaga acccactcca ccatgttgtt    180

ctcttacctc cacatacact tgaagaatat gcacacccca tgcatacgca tcacacacac    240

actatagtaa taacaataag taaaagcata acaatgataa taataacaac aactactact    300

actcagtgaa tcacatatgc agtgaaaggt ctccttccac cggagtgtcc agccacagag    360

tagccttccc cacaggcaag tgagcttctt acatatgttc ttaggtgtat actaagcata    420

taagaaaagt tctcaagtac actttattct cctttcccct atgtctcaca ctatgatata    480

acactatata tcttgaattt tctcctaatc caacctgaag attatgaagg ataaagtaga    540

caagaccaat tactggctaa ggattgattg attgtagcat tttacttaaa gcacagtttg    600

tgctgcctgt ttgccaggca tgacttcact tgctacctgg aacaaaatga tgtggagaca    660

tagctgaaac aacaacgcat gtgtgaagaa ctccctttgg agggctgaag cgatggctca    720

gtgcttaaga gcactggctg ctcttccaag agacctgggt tcaatcccca gcacctgtaa    780

aagtaacttt tattcatgtg atgtgattgt cgtctctaag ccttactgcc tctgtctgct    840

atcctaggcc tagtcctgga agcttccagc ctctgtacaa catggtggag tgggttctct    900

ttttctgttt ctcaggggat tgggctcagg ttgtcacatt tgtgtggcag atactttttc    960

ttgatgtgcc acctcactgc tgcactggcc cactgaatta tgacctgcgt aagaacccag   1020

caaacattaa aacttagaat gttttgtttg ttttggtttt tttgagacag ggtttctctg   1080

tgtagccctg gctgtcctgg cactcacttt gtagaccagg ctggcctgga actcagaaat   1140

ctgcctgcct ctgcctctgc ctctgcctcc caagtgctgg gattaaaggc gtgcgccacc   1200

acgcagggct cacaggtttc attcttgacg ttttatttta tggttttggt gtttgccagc   1260

atgtatgtgt atcacatgta tgcctggtgc tttatgaggc cagaaggagt tagatctcga   1320

aaaaccaaaa aaaaaaaaaa aaaaaaccaa aaaaaaaaaa aaaccaaaaa aaaaaaaaaa   1380

ccaaaaaaaa aaaagaagcc tgtatgatat ataattagcc tatgataata tttgccaatt   1440

ttaagtgatt tcacctgttc tcagcagttt ttagtaattt gccccatcat aattcaggtt   1500

gaaaacatca ccaccactgt tttaatagtc cttatgctga ctctcaaccc caagcagcca   1560

caagtctctg tctcttcaag ttttcttttt ctttattggg agagcttgat tgcagaggcg   1620

aaaccccaag cccagcactg gtgctgctta tataggccta ggagaggcgt gtctcacacc   1680

cggattggtt atgcattcta cctcatttgc atgcctcaca cctgattggt tatactctca   1740

gtacctcaca gaacctcatt atcatgcccg ggccaggcag tgtcttggca aaaaacgtta   1800

ttgcatatgt acacattggt tgtttaccca accgtatgcg tggtggccag tggtagccag   1860

cgtcaccttg taatggcata tgtggcttcc cacaggtcct gctatctatc tagccttgaa   1920

ctccaagtat atgtgtattt tgtttcttct tgctgaaaag ccatttcatg ggcagtccac   1980

tgcttgtcca ttccccagtc aaaggacaca tgatggtttc acttctcggc tattataagc   2040

actgctgcaa tgaggattct tttgaaatgt tctattttgt ttttattttg gttttttcaa   2100

gactcagttt ctctgtgtag ccctagctgt cctggaactc tctctgtata tgaggctggc   2160

cccaaactca cagagatcca tctgccctgt ctccaagggc tggaattaaa ggcttacacc   2220

accacagccc agcgtgcaag gctctttatg caactataat ttcatttctc tggagtaaag   2280

acctaggaat gaagatcata tggcaaattc acttttagct cttaaagaaa cagccaaatt   2340

cttttctaaa ctaacagcat cgttttacat ccctactgac atgacagctt tttgttttta   2400

tgaatcttga attttcaaca atatttgtca ctacttcaat atagccacat taacatttat   2460

tttgtattat ttttattttg tgtatatggg tgttagggct gttggtctat ctttgcacaa   2520

tgggcatgca gagccaatgg aggccagaag agggcattgt atccctgaga gtggagttag   2580

tgattctagc tgctaggtgc atgctgaaat ctgaaccctg cctcctttgg aaagtaaggc   2640

ggtgctctta accgctgagt catctcttca gctcagagca atggcttttt acacaacaca   2700

taatattaat ctttgcccca acctcacttt cttaatggtg acttttgaaa tgcaaaagtc   2760

tttttgataa attccatttt atagattttg ttgcatttgg gaggtcatgt ctaagacaag   2820

attgtctcct gtctcattat ttgtaggtca ttgttaggga tttggtctag ctttaacaat   2880

aaatgtcact tagaatatat gtaaagtatt agtaacaaat aagaataaaa gatatcattg   2940

aaaaatatct gaacatgtaa ttttattaaa ctaaatctca cttcatagca gttatataga   3000

tatacactat caagtacagc aaagaagtgc ctggtactcc tatgcatgta tgctaccaat   3060

ctcttgctga ggtattgagc tgtgccaata taattttttt taaggggtat ctcagaatag   3120

ggtagggttt tggttggttg gatggttggt ttgaagtaac cctaggttag tccaaactca   3180

ctgaatagca gaggatgact tcggatgctc aattctcctg tctctatgta ccaagtgcta   3240

gaattacagc atgccccacg gtgtcccact cactacagtt ttaattttca ttttccttac   3300

taaaactaag aaccaaggct ggagaaatgg ctcagacgac ccagattcaa ttcctagcac   3360

ccacattgca gctcacaact gtctgtaact ccatatccag ggaatctgac accctcacac   3420

agacatacat acaggcaaaa caccaatcaa tgctcataaa tatttttcaa aattaaaaac   3480

taaaaattaa ccagacttgt aggctgtata ctgttagcat tgtatagata aatctaagac   3540

caacccaaaa tagcgcgctg cctggcacct aatacctgct caaaacgtct tatacattgt   3600

ccttgttggt attgttactg cttctaagcc acaacgagtg aaacggctcc aaaaagccat   3660

aggacagaag ggagcgtaaa aagcaaaaag tcacagtctg tgcagagccc gacaccacaa   3720

tagtgtatct gccctcaaga gatggatttc caaggtctag cttcatattc cacaaaactt   3780

caaagcacgc agtcatagcc aaccctgccc cgccccgccc tgctgcctag cccaatccca   3840

aagccacttc cggcccgccc cccaccctcg ctagctgcca gcaaacgtgc gcatgcgcct   3900

cctcggtgtt ttctctgtca ttagcgaagc ccgacaccgc cctacttccg gcgcggggta   3960

aagacccaac aggctcggcg ctcagcgatg atgtcagctc cggttgcctt gctgagtcgg   4020

aagtaagaac cttttggtcg ctgtagctgt gaggtgtcgt cgtccctgcc ctttcaggct   4080

ccggtaagag gcaaggtata agaggacgag agtgttgagg ctgcgacccg gttttctcct   4140

aagcaattgc cagtcaaggc ccctgcatgc ctgctgttct caactgcttg cctgacccgg   4200

gtccgtcttg aacttcgacc ctgtctaatc tggaaaccct tacggtgctc cggcgtccgg   4260

tggctctgca cattcccttc ttctttgcca agtccctgct aggaaaggcc cgagtgtggg   4320

ctgtggctgt cttttgactt attttatcta ggacctgcgc agggtgggtg ggtctccctg   4380

ctgcctatga atgttactga accccaaagg ataaaatacg aagagtgaac gacagtgcca   4440

gatgccaagg agacaaaatg aagctcgact catagcaatc aaaccagtag ggtgcgtgta   4500

gcaagaggtt gacttttaaa gcgagtgacg gcttcccagc tgtagctctt tggattctgc   4560

tcgagttttt cttggtcgag aaaacatttc tcagattgac catagagtca gacgttttgt   4620

gtttagtatt gttcctttta ggattctttt ttgtctccta gagcaagaat gggttaagtc   4680

tcaatgtcat tgactttttt ggtcccagag acataaaatg gggcccaaga tgaaatgcca   4740

gggtttgtta gagacggttt tgtttgttgt gttgtgttct ttttttgttt tcggacgtgt   4800

atgtgcttca cttgatgaga tcctagcttg cagataaacg tattgcaagg atttttgtta   4860

cgacacctaa tgtaacactg aaggtatttc caggtagaca tgttactttg ggaacatttt   4920

taaattccaa aatagagact ttatggagta caatttaata cagtgtaatt tgggcttggg   4980

gtagggagtt gctggggtta taaactaagc cctggtgcat actaagtgct ctagaacaga   5040

gctacaccca accccacctt agccatagaa cttggctata gcaatctgtt tttcagtgtt   5100

accaatagtt ctactttaaa actggattgg acatgatctt aaaatatctg tatgctctca   5160

ggagccagta gtggccttaa aggattagca gcactctata taagtagaag cttgagtcag   5220

gagaaaatga gagaattgta tgggtccaat ggttgacact tcctagagat gtag         5274


<210>  9
<211>  17070
<212>  DNA
<213>  Homo sapiens

<400>  9
gtggctcatg cctctaatcc cagcactttt ggaggctgag tgagtggatc atttgaggtc     60

aagagttcga gaccagcctg gccaacatga tgaaaccctg tctctactaa aaatacaaaa    120

attagctgaa cttggtgaca catgcttgca atcccagcta ctcaggaggc tgaggcagga    180

gaatcacttg actccaggag acagaggttg cagtaagcca agatcatgcc acagcactcc    240

agcctgagca acagagcaag actccatctc aaaaaaaaaa aaaatccctg tctcaaactc    300

ctgctttcca ggtagatgga gcgggataat gtgctttaat tggtgaaggg tttctgatcc    360

ccatttatca tgcagaaggc aggagcaagc cagagacagg tcctggcgaa aggaagctaa    420

aatggtgcct ttgatacagg ggaaagggat acgaaagggg cttaggtgag acctccttac    480

agctagtggc acctggtcag cagggccgta gagttgaggc catcccctta gcagcagtgg    540

gactttgtta cacacaccct ctgagtcttg gtgagaaact agtcccaggg ccccttgttg    600

tctctgccac tcccattcat gacatcatgg aaacttctgt gcggctgggc tcctgaacac    660

agcagcctgc cctcggctgg atgaggcagc caaaacccta aaagggttgt gatagggact    720

ggagtcaaca agtagctgtg ggaacgtggt ggcgcagacc cttcacccag ggagccctgt    780

gggctagaaa caccagacag ccaggatgtg gcgagagact gcccaacaca ctgtctgtgt    840

gaggcagagg aaggaaggag atgaaggaag aaacaggtag gtaggagggc gagatcccaa    900

gcaagtcagg acaactccca cgccttgccc aggagcctta agaagcccag gcacctgctg    960

agtgaaagag gatatattta ttggctgagc aagaagggaa ggtacagttg gtaatggctg   1020

cttctagaag ccaccagtct caggttcact tgttccgagc ccagtttcct ccaaggtggc   1080

tgtactgagc atcatctcga tctcggaggg gctaagagag gagaagagaa aacggtcagg   1140

aggcagggtt agaactcttc aaggaagggc cccagcaggc cctgacgatg agagctcctg   1200

cctgacctct ccagtcacac ccagcaatga actccccagt aggacccttc ccacgtgcaa   1260

acagcattca gtgtgagcct ctctatcccc acttaccctc ccttcattcc tgcctccttc   1320

ccctcaacgc tcacctgata gacctggtca ttcctcaaca gagcttgtgt gtcggcagct   1380

agaagaacca gagagagaca tcaatggcct agcagatggg actgtgagat ccaccctccc   1440

acaccctcag aagtctgcat gagtgatatg aacacacaag ttctttcaac agtcaaagtt   1500

ctaggagtct ttaggagatt gcaagagtaa ctcccagctg agactaaacc taccaccagc   1560

cccattcctt agctggtgca taagctcact ggtacacaca cacacacaca cacacacaca   1620

cacacaaaca cactctcatg ctctgctctt ccactaaccc ccagacagcc ttccagtctc   1680

atgtccagca aagcagaaga ctcccaaagc aaggagcaga gtggcaatga catcagtgac   1740

aatgatgcca gccacggtgg ctggatccag ctccacacag ctctggcaca ctgtggggga   1800

agggaggaga gaggagaggt tgagagcctt taagatcagg gaaccatcct ctgcctccta   1860

gggcaaccct tagatctctt atgccaaaac ccaaacttca ataagaccct gggagaaagg   1920

cctggtgatg ggcttgccac accttcctcc accctgcatc ctaaggaatc cctgggaaga   1980

gccaagaagt aatctcagct tttgggacct tgaacaaggt ggtgggccaa acctctcacc   2040

caaccaaggc tgcagtaaca tgacccctac tgctctgtct tgctgagtta agctctctct   2100

tccactttga aggtccccaa atctggcttg taccattaca atagtgacct cactttgttt   2160

agagaacaga tgggttcacc atatccctct ctagccagaa agttctcaca tccagaagcc   2220

ctatccattc caacccaaag ggttcaggaa gcacgtactt cgataatgaa cttgcacggt   2280

agattctttg tccttgtata tatctgtccc attacaccta tatattcctc gtgggtccag   2340

gatgcgtttt cccaggtcca gtcttgtaat gtctgagagc agtgttccca ccgttccctc   2400

tacccatgtg atgctggtat tgcaattcac aaacactctg tcctcaagtt cctctatagg   2460

tatcttgaag gggctcacta aaggggaaaa aatatcacag ttggagacag ctctttgatc   2520

tgcaccaagc cctttgttct gcggaagctc atacttaaca gagaccattt tcctggtcca   2580

ggacagttta tggcttccat caagagagac agaagtcaca agaaaaagcc ttcagaaagt   2640

tccccaccaa ctgcaggggt caagggggac atgaggatgc cattcaagca gaggacaggt   2700

cttggggcct tggtgcaaaa gaggacccct cagagcagga ttgacccaag caccttcctg   2760

gaaatgaatc cagaccactg atgaggagta gggggagcac ggaccactga agcacctgga   2820

agatgtggaa agacagaaga acattcctcg attggaaatg tctgcatttt ttcttcaagg   2880

aaacatctaa ttccacttcc cagccatcta caacactccc acttcagctt cttatcctca   2940

tccttcctca ttgcccctgc tccattgaca accaagaaag cggggctctc aacactgaag   3000

cctttcccag ggccagggat ggctgtgggt ggagaccagc tggtttacca gcccctgaat   3060

tatcagccaa gtggtccaga acgggaccag ggcaaatccc atgtacagtt ttccaccctt   3120

ggttagaagg aggagaacag gaaaaaaatt ttattgaatc catccctaga gctcctcaca   3180

agtcaagtct tgtgggagac ttttagggct ggaggtgagt gcagcaacat tccagatgca   3240

gtgagttcct ctgacagcct gagcacatct ccacaggcca cagaggcact acagtctatg   3300

cctccaaaca cagggaaaag tggaggctac attcattcat cctgggcttc acactaagtc   3360

ccaaatttgg atacaagagc atcttctaga aaaccctgaa acagctgttg ctcacacttc   3420

tgaagcaggt tggaagtata tgcatgtatc ctcagggaga cacatgcaca tcaaatgctt   3480

cacgtcctac agtcgcgtcc tcttcaggga tctgtctcca gtggaaatcc tgagtgccct   3540

agtgcagcca actattaggt gaccattgga cccagtttgc ttagtgttga aggggttcct   3600

cggacatggg actttccatt ttaaaactga aattggcaaa ctgagatgag ttaaaatcct   3660

accatgtaac aacccctcaa atcttccctc cgtcctgctc aacctaaagt taacttctct   3720

taaagcattc acataagtgc taggacatgc ctccagggat gacataatca tggccaaaca   3780

aacaagagtc ctgattccag aggccatcag gcctaaaagg agtagtgcag gaagctgtgc   3840

tcccatggcc agtcccagat tcaggtacat acgtactgag ctattttctg cagatctctg   3900

gcctaaggcc ttctgagaga cattctaggc ccacatgcac ccatggctgg agtcagtcaa   3960

agccaagagc ctgtttccca gactctatgc tacatcctgc ccctgccctc ctgacacccc   4020

tggggtgcct ggtgaactga agctagcacc gagaagcact tttttttttt tttgagataa   4080

ggtctcacag gttgcctagg ttggagggca gtggcatgat cacagctcac tgaagccttg   4140

aaatcccggg ctcaagtgac cctcctgcct cagcctctca aatagctggg actacagttg   4200

tgcaccacca tgcctggcta attcttttgt tttttgtaaa gatagagtct catcatgttg   4260

ctcagactgg tctcaaactc ctggcctcaa aggatcctcc cacttcggcc tcccaaagct   4320

ctgggattac tggtgtgagc caccgtgcct ggcaagaaac actttcaagt gggcctcact   4380

cccatcagta atgtccctct caggtccctt cccccaccca cctggagtag ccttaccttg   4440

cgagagaagg gtagccagta ccaggccaga gagaaacgtg ctatgttcca tctcccagcg   4500

gaactcatcc agtagataaa gccaggtcac cgaactatca gcctgggtga gagctgccct   4560

cccctagctg actcacaggt accggaaaga ggagagtggg ggaggaacta gaagatgtct   4620

gcttctctgc tttctgccgt tgatggtggg aaattttcag agtgggggtg ggctaggggt   4680

agggtaggaa ggaagcggtg taaattgctc tatctctgag cagggagctg gcagagaata   4740

tggaaaaggt ggcctgaact ttagcgtccc tattgacaat gcaaccacat ttacacacaa   4800

cctaaacact gccacatctc gaagcccctt gagagaagcc gtcggcccca tagcgcaagc   4860

cgtagcagct agatttctca tggaggctga tctttctcag gacccttcac taggcagcca   4920

gggacaccag atctagcagc ttcttgtcag tgggaggttg ggctttagag accccagcca   4980

gagatttgaa tcctgggtcc aatactgcct acctgtgggg cctgggccag ccataaaatt   5040

tttcagagtc ttattccatt agtaccatta ttaggattca aacaagatat ttgcatggtg   5100

cctcacgcat catatgtgct cattaagggg tagttattaa taataatata attgactgac   5160

aggcaatatt gagcctcccg gtgagacaaa tggacctttt tcccctgtgg cctacgagga   5220

tctgaaactc ttcacgctgc tgcagttaga ctgtcactta cctggggaca gagtcatgcc   5280

tgtcttgctc actgctgtat cttgtgcctg gcacataacg ggagctctgc acatttttgt   5340

tggctcactg actgactggc tgagggagat aggggcctga gatcctggac attcagtccg   5400

ggctctggcc cctgaaaatg tgctggcctg tcctcggaat tgttccacct attgccttcc   5460

aggcgcctct ttcatgatct caaaagaata gtgaaaccag gtgccgtgtc tcacgcctgt   5520

aatcccaaca ctttgggagg ctgaggcagg tggatcacaa ggtcaggagt tcgagaccag   5580

cctgaccaac aaggtgaaac cccgtctcta ctaaaaatac aaaaattagc cgggcttgct   5640

ggcacgcacc tgtaatctca gctactcagg aggctgaggc aggagaatcg cttgaacccc   5700

ggaggtggag gttgcagtga gctgagatag cgccactgca ctccagcctg ggcaacaaag   5760

tgagactctg tctcaaaaaa gaaaaagaaa aaaaaagtga aaaaaattcc tgaatgaagg   5820

cctggactga ggtggctttc catttggagg tccagcccca agcatctgag agtccctcct   5880

aaattcatta cctacagcaa caacaactag caacaagtaa caactggcta cgatcctaac   5940

aactaatgac agggacattt atctccctca tgaagaaacg gtcccaggac catctcccac   6000

ccagcatcca ttgcggttcc ctgtgcaaga tgagtctctg agtgggaatc cagcactctc   6060

tccctcttct tccccaccac cttcaccctc cttaacggaa aaacaaaagg catctgcacc   6120

tgcagccctg ctgaggcccc tgctgctcac acttgcagca gagggtggag gctctgggtt   6180

cttgccttct ctcaaaggcc ccagccccaa cagtgatggg tggagccagt ctagctgctg   6240

cacaggctgg ctggctggct ggctgctaag ggctgctcca cgcttttgcc ggaggacaga   6300

gactgacatg gaacagggga agggcctggc tgtcctcatc ctggctatca ttcttcttca   6360

aggtaagggc ctactagggg tctggaagcc tggggaaggg ctcaagggaa gagcccatca   6420

ctagtgagac aggaatattg gtatccctaa ccttcagcct acctctgctg tcaccttaga   6480

gttcaaagaa gggcaaaatg gaggctctta actgttctct gctagagaga aacagtgtcc   6540

catggaggag aaggaatcct tgtctctgaa aaatgcaaac agagtactta aatggctgaa   6600

gagaggaccc tgttaccgcc atcttagatt tgaatgcagc ccaaaagggc ataggccaag   6660

aaactaaaag gaaaaagtat atgttcccta cttcagagct gggggctagc agtcgaccta   6720

ggaaatgtcc attcactcag ttgggcagtt ggccaattgg tcaacaaaga tgggtgagac   6780

cctaatatgt gatatgccat gaggaaataa aaatgaataa aacacttatg ctctacagaa   6840

ctcatagtct cattggagag attagttttc atggtgccag actgagtgta cagtatagta   6900

tgggtgcctg catgaatact ccattggact atccaatagg aagtggatga actgggttga   6960

tgcctggagt ctggacatcc tgggaaagtt aaaaccatgg aatttgctga agtcacacaa   7020

gtactatgtg aggaagaggg agctgaagat ggaacagtga gggcaccaat tttaaggggc   7080

agttagagaa aaaaaaacat tccaggaaag agataaaagg agaatcaaag agctgaaata   7140

atcaaatgta tgcactacct tggaaaccaa gagagtagag agcttctaga agaagagaat   7200

taccaagagt ataaaatgtt aaagagagcc cactaatata agaatatatt taaaagttta   7260

agtctgcggg atgtggcaga atatgcatca tgggtgattt agcacagttt cagcagggta   7320

ttgtgagtgg aagccaagtg aaaattggta gaaggtgaag gtcaggtgat gaggtcagca   7380

agtgtagact attctttaaa gacatttgga tgaggaggga gaaaagactg ggtggtaggt   7440

agaggaggaa gtagagtcta agaataaatg tttttgaggg tgagagaaac ttgagcacat   7500

ttctaggcta aaggagaaga tgatgagtag agcaaggtcc tggagttgat ggtggaagga   7560

cagagtcaag agtggggtca agagcacaga gaggaaggca acgttaccct ctaagaccag   7620

gagaaaggaa gtgcaaacgg cactggccac aaataggttt ataaagggaa aggaagctaa   7680

aggagaaagg acaataacaa cttccgtgtt ctaaaaaatc caggtgggag gcaatgccac   7740

ctgctgaaac tgagctgggt gatgaccggt tgggagactt gaagaggaca gtgagagttt   7800

agaatagaat tatttctgag agaaatgcaa ggaaaagtca ggtaaagaca acacaggttg   7860

aggagcaact ctcaagcctg ggtgaggtgg ctgcatatca tggaaagagc atttgagttc   7920

agcagtagaa aacctgagct ctggatccag cttggacacc aatgagctat gtgtacttga   7980

acaactcctc cactgtctgg gagttctcat gccagccaat ccagaaatgt ggcagggacg   8040

ggcatggtgg ctcatgcctg taatcccagc actttgggag gtcgaggcag gtggatcacc   8100

tgaggtcagg agttcgagac catcctggtc aacatggtga aactctatct ctactaaaaa   8160

tattttaaaa attagtgggg tgtggtggtg ggtgcctgta atcccagcta ctcaggaggc   8220

tgaggcagga gaattgcttg aacccaggag atggaggttg cagtgagcca acacggtgcc   8280

actgcactcc agcctgggcg acagagtgag actccgtctc aaaaaacaaa acaaaaaaaa   8340

aagaaatgtg gctatatgaa ctcttaagtc ctaaaaggaa acctcactca gatatgcaac   8400

attaaaagat gtcaatcagc caggcacagt ggctcatggc tataatccca acactttggg   8460

aggctaggga gggaggatca tttgagccca ggagttcaag accaacctgg gcaaaatagg   8520

gataccctgt gtctacaaaa actacgaaaa ttagccaggc atgttggcat gcacttatgc   8580

cagctacttg ggaggctgaa gtgggaggat tgcttgagcc caggagcttg aggctgcagt   8640

gagccatgat cacaccactg cacttcagcc tgagtgacag agcaagaaaa aaaaaaaaag   8700

atgtctcaaa aaaaaaaaaa aaaactatgt caatgatcag tgcaatctcc ttccctgaat   8760

ccaatttaga atgaggggtc tctgtcttct ctcggtcttc tgaccaggtg gtcaggagaa   8820

aaactagtta gaaacctctt taactgtttg tcttgccttt tctcccattt gctcatttat   8880

tcatttgcac attcattcaa caaataaagt tcctaccatg ttccagacac tgcactggat   8940

actgttcaaa aataatcccg ccctgcatga ggttctaaga cagttcactt cttgtatttc   9000

cattatactt tgactcatga ccgcctctcc ctatcacaca cactccacct ctagccacac   9060

tacctctctt gtccttttcc aaagctgcat cttattcagc tattctttct actcagaatg   9120

actttctcta tctggtatat tcttgcttac tcttcaaggc ccagacaaat gtcgtttcct   9180

ctattaagct ttccctgatc ctcacccttg gacaaaatta atagcttcta cccttttttc   9240

atatgcagtc atataagcac taaaagataa tgtatacatt ctattaaatt aattgcatat   9300

atgttttaat tttttcactt cattcataaa ctttggaagc agcagttgat tcttcatatc   9360

agcactcttt tctttcataa tatctaatta ttttaggtca taatagtcct cgttaaatgt   9420

ttggattaaa tctaattgaa ttgaattcaa gtgccagatc tctgtaatat gtctaccatg   9480

caactctact accctaaggt tttgtttgtc tgtttgtttg tttttatttt tttgagacag   9540

ctttaacacc taggctggag tgcagtggtg caatcttggc tcactgcaac ctccacctcc   9600

caggctcaac cattcctccc acctcctgag tagctgggac tacaggtgca taccaccatg   9660

cccggctaat ttttttgtat tgtctgtaga gacagggttt cgccatgttg tccaggctgg   9720

tgtctaactc ctgggctcag gcaatctgcc cacctcagca tcccaaagtg ctgggattac   9780

aggtgtgagc cactgctgcc agtcaactct gagttatgag acagatttga ggactaattg   9840

aaaagctaac ttccctggga catccagggt ttttataata aaaggatcac caaggctgaa   9900

tattttataa ggaactcagc ctaaaggttt tggatagtgc acacccactc cttgccaggg   9960

cattagctgc tcaagaagca gagtgttctg gactggatag gcaatatcct tacttacata  10020

tactacaata caattctgat gctaaccccc caaattagtg tcagacccta caggttaaga  10080

gcatggttcc caaccagatt gccctcactt taaatgccag ctacaagttc agggtacccc  10140

agaccactca catttctgac aaactgcctg caatcttaag gattcccatg accctcctca  10200

ttgataattt gctagaataa ctcacagaat ttaagaaagt gctgtacttc ctatttcagt  10260

tttattaaaa aataaaataa aatcagaacc agctaaatga aaagggcaag gtctaggagg  10320

gtcccgaaca cagagcctcc gtgccctctc cccgtggaat tagaacacat cgcccccagc  10380

actctcccac actctgccag cacattgatg ggttcaccaa ccaggaagct ccaccaagtt  10440

tttattgagg tatctttaca taggcatgat tgattgaatc attggccgct tgactgatct  10500

caatctctag gatcccttcc tggggctgat accactagtt tcaaagctgc aatcctctta  10560

ccatatggtt ggtcttgacc agcaccatcc tgagtcattg ccatgcataa actcaggtat  10620

ggtctaagga tccaccacag ataacaaagc cactcctgtc actcatgaaa ttccaacggt  10680

tagaaacacc ctcccaggat accaggacaa agatgagaca aattgtttat tatcaccttg  10740

aattcaattg agtgatttag tctacaatcc ggaaaactaa gtatagatac taccattttc  10800

atggatttgg atctttcttc atcttggcct caaataacca tggaaatact tcagggcatc  10860

tgaacaactc catgcccagc taatactcta tctctcttct gtctttacag gtactttggc  10920

ccagtcaatc aaaggtagga gaaatggctt ctttctatac tcagactcag aatattgacg  10980

gaaatttggc ttcctacaac agtagtccta caggagcgaa cagtttagaa tgaatgaaat  11040

gacggggata gagaggtgat gtctctattg tcaaccaaat cagtgacctg acataacctg  11100

ttccgggcag cttgcctgta gctaagcatt taactggtct cttacaggag aagcaggacc  11160

ctagtagcta gggacacatc tcaaactgtg acccatgaac cagtaggtat tggcgtcacc  11220

tgggatcctg acgttagtct ctgtcaatcc ttctctttag ttcatctatt ctacccaaag  11280

tgatctcatc atctggtatg ctgttagcag tttcttacct gtatagtatc ttccaaataa  11340

catgccccaa aatcccaaag ttttacccct actaattaca gcaatgtctc ttttattctt  11400

caccccctga cgcagatatt ggcgtcaccc gagagcatgt tagtaatgca gaatctcccc  11460

tccccagaac tactaaatag cacctgaaat tttaacaaga tccccatgtg attcatgtgc  11520

acatcaaagt ttgagaaaca ctactctaat gatctcctgg tatgcagaag cagggagaat  11580

ttcagaggca agatccttaa tagaaccacg gcttttctca tttcaggaaa ccacttggtt  11640

aaggtgtatg actatcaaga agatggttcg gtacttctga cttgtgatgc agaagccaaa  11700

aatatcacat ggtttaaaga tgggaagatg atcggcttcc taactgaaga taaaaaaaaa  11760

tggaatctgg gaagtaatgc caaggaccct cgagggatgt atcagtgtaa aggatcacag  11820

aacaagtcaa aaccactcca agtgtattac agaagtatgt aatccccttt ggtctgtttg  11880

ttgtgaaatt aatcagtatt tgctgttctg gtgagctttt tatctggggt gaaagtggaa  11940

atagatcctc aacagtaata ttatcgcctg ttctcttaat ttcagcttgc ctcttttaaa  12000

atactgtaag atacttccct caccctattg aaaaactaca gccagtcctg taaaattttg  12060

tttacctttg ggtgggctcc atggattcaa gcaattcagc actgagttga atgaaggggt  12120

tggggagaca gaggtgatca taaggtgagc agcagtgaga actggagcgc agtggagcat  12180

gaagagtatc tagtcttcct tctgttccag atacttcctg gtagttagac tacatgggct  12240

tccccaggaa tcctggggga cttaagagca tcaagatgca ttgagttttg gcgcaaggat  12300

cttcccttgc cctgccaccc acagaggaaa agcctgctgc cctccacagc ggcattattg  12360

cagacaggca ggagaaaacg aaccaggaaa aacaactttc gcaacctgaa ggtttgtctc  12420

tccttttccc tacagtgtgt cagaactgca ttgaactaaa tgcagccacc atatctggct  12480

ttctctttgc tgaaatcgtc agcattttcg tccttgctgt tggggtctac ttcattgctg  12540

gacaggatgg agttcgccag tcgagaggta aaagaatgct cttagatgag agatgggacc  12600

acctgagacc ctcagctttc ctcctaccat tatgtaccca atggaagaga ctgagttggt  12660

gcttcttgct agtgtgcata gttgggtgag gctgtatttc tctgagacag gagaaaggat  12720

acttggtgtt atcacagcat gttcacctgt ctcaagatac agctccctct gtgaaaaaaa  12780

aaaaaaacaa aaacaggcgc agtggctcac gcctgtaatc acaacacttt gggaggccga  12840

ggcgggcaga tcacgaggtc aggagatcga gaccatcctg gctagcacgg tgaaaccccg  12900

tctttactaa aaatacaaaa aattagccgg gcgtggtggc gggtgcctgt agtcccagct  12960

actctggagg ctgaggcagg agaatggcat gaacccggga ggcggagctt gcgtgagccg  13020

agatcgtgcc actgcactcc agcctgggcg acagagcaag actccgtctc aaaaaaaaaa  13080

aaaaaaaaaa ctattttaag taaaccctta catacagaaa agtgaatcac aagcatacag  13140

ctcaaaaaaa aaattcacag agcaaataca cccatgcagc cagcacataa tttaagaaag  13200

acaatattac caatgccatt gaagcccctc ttgtggtcac ttccagccac tacccatcct  13260

caagagtgag cattgtcctg acttctaaca acaaggatta actttgcttg tttttgtcct  13320

ttatgtaaat ggactcatat actaagtatt cttgtgagta gcttctttca ctcaacaaca  13380

tgtttatgtg ctttatccat actcttgtgt atatataaaa ctcttattgt tatttagtat  13440

tccattttgt gaatataacc caatttatta tgcattctac cttgtgtgga ttctgtttct  13500

tttttgtgca gcttcagaca agcagactct gttgcccaat gaccagctct accaggtaag  13560

gggatgaaga ataaaagaga cattgctgta attagtgggg gtaaatcttt gggattgagg  13620

ggcatgttat ttggaagatc ctatacaggt aagaaactgc taacagcata ccagatgatg  13680

agatcagttt gggtagaata aatgaactaa agagaaggat tgacagagac tgaggtcagg  13740

atctagtgag cacaagttga agaacacact gagagggaca cacgaagaaa ctctcgacag  13800

gctgggcact cactatagac aggccatggc tcatgcctgt aatcccagca ctttgggaag  13860

ccaaaacagg tgaatcacct gaggtcagga attcgagaca agcctggcca acatgatgaa  13920

actctgtctc tactaaaaat acaaaaaaaa ttaaccaggc gtggaggcgc gcgcctgtag  13980

tcccagctac tcaggaggct gaggcaggag gaccacttga acccaggagg tcgaggttgc  14040

agtgagctgc gattgtgcca ctgcactcca gcctgggcaa cagagaaaga ctccgtctca  14100

aaaaaaaaaa agagagagag agaaaaagaa aaaagacaga gcctccatct ccttgtcctc  14160

tttccatcct caggaccatg aagtacccac tccaaattct cacatataaa aaacattcaa  14220

taaacatgca tcaaattaat taatagagga tggaaaaaat gacttatgac tgtgctgtcc  14280

tttccagccc ctcaaggatc gagaagatga ccagtacagc caccttcaag gaaaccagtt  14340

gaggaggaat tgaactcagg actcagagta ggtgggttct tcaatgccaa ttctaataaa  14400

ggacccttgc atcaactgcc ctcgcaattg cttctaagtc tagctccctt ccctaagcgg  14460

ctataagcat cagactctgg ggatcaggga ttgggacgtg gtttggggta ctcttttcta  14520

aaaattctgg ggccatactg attgtcttgg cctaggtaaa tatgaatttt atgtatctgt  14580

aaatcctgtc agagcagggc ctcaagccat agagatgctg aatattaatc ttaacctaca  14640

tttgaatttc tcattatcta cactattaac attttgggct aattaattat ttgtgatgag  14700

gggctagcct gtgcattgta ggagttatgg aagcatccct ggcctctctc caccagatgc  14760

tggtagattg tccagtgtga caatcaaaaa tgtgtccaga cattaccaaa tgtgtccaaa  14820

catcacctcc agggcaaaat cacccttagt taagaaccac taacccatat taaccttcca  14880

atcaataaat caatcagtca gaagttatga tttaattaat ctatctgaag tttctatcag  14940

gaagacaggg ttgaaagcat tatttgtttt ttttgaacaa attgcaattt ttcttttttc  15000

agtccaggtg ttctcctcct attcagttcc cagaatcaaa gcaatgcatt ttggaaagct  15060

cctagcagag agactttcag ccctaaatct agactcaagg ttcccagaga tgacaaatgg  15120

agaagaaagg ccatcagagc aaatttgggg gtttctcaaa taaaataaaa ataaaaacaa  15180

atactgtgtt tcagaagcgc cacctattgg ggaaaattgt aaaagaaaaa tgaaaagatc  15240

aaataacccc ctggatttga atataatttt ttgtgttgta atttttattt cgtttttgta  15300

taggttataa ttcacatggc tcaaatattc agtgaaagct ctccctccac cgccatcccc  15360

tgctacccag tgaccctgtt gccctcttca gagacaaatt agtttctctt tttttttttt  15420

tttttttttt ttttgagaca gtctggctct gtcacccagg ctgaaatgca gtggcaccat  15480

ctcggctcac tgcaacctct gcctcctggg ttcaagcgat tctcctgcct cagcctcccg  15540

ggcagctggg attacaggca cacactacca cacctggcta atttttgtat ttttagtaga  15600

gacagggttt tgctctgttg gccaagctgg tctcgaactc ctgacctcaa gtgatccgcc  15660

cgcctcagcc tcccaaagtg ctgggattac aggtgtgagc caccatgcct ggtcttaaaa  15720

ccagtttctt atatatctct ctggaggtat tctaggcata tatgagcaca ttctcaagta  15780

catattatcc tcccttcccc tatcttttag acaaatgata tcaaactata catcttgtga  15840

gattattgca taccattata tgaagatacc attatatcct ttttaatgca accatattgt  15900

acaaatagac tatgatttat ttaacctgtt atctatcagt ggatatttaa gttggtagtt  15960

ggttccaatc ttttgctctt acaacaattc tgcaatgact aacattgtat aaatatcatt  16020

tttaaaaata attgcattga agcataatgt acatgccata aaatccaccc atcttaagtg  16080

atttcacctg ttctcagaaa tttttagtaa atttaactaa ttgtacagcc attaccataa  16140

tccagcttta ggacattttc ttttttttct tttcttttct tttttttctt tttttttttt  16200

ttttgaagtg gaatcttgct ctgtggccca ggctggagtg cagtggcgcg atctcagctc  16260

actgcaacct ccacctcctg ggttcaagcg attctcttgc cttggcctcc cgagtagctg  16320

agactacagg cacatgccac cacgcccagc tcattttttg tgtatttagt atttgtgtat  16380

ctagtatttg tgtacttagt agagacaggg tttcaccatg ttggccaggc tggtctccaa  16440

ttcctgacct caggcgatcc acccgccttg acctcccaaa gtgctgggat tacaggtgtg  16500

agccaccgcg ccaggcccgt aactgtattt taatatagcc attctatgga tttaatatgg  16560

tattttatta tggccttaat ttgcatttcc ctagatacta accatgctga gtgtcctgtc  16620

ttgtgtttat taaccattca tatattttta gtgaaatgtg tatcaaatct tttgcccatt  16680

tttaagttga cttatttgtt tgtcttctta ctattgggtt gcatatgttt ttgatataag  16740

tcctttatca gatatatgat ttggaaatat tttctaccaa tctgtggttt gtttttctta  16800

atggtgtctt ttgaagtgca aaaggtttga attttgaagt acattttatt gattttttct  16860

tctatatatt gtgcttttgg tatcatgtct aataaatctt taccaaaccc acagttacaa  16920

agattttctc ctgtcttctt tttatacttt ttacagcttt atggttttag ctctaacaat  16980

aaatgtgatt ttgaacatac ataagactat ttgtaacaaa cacaaataaa ttgaattgtt  17040

gggcacttgt atttgcattt gtaattttat                                   17070


<210>  10
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  10
cacaaataaa ttgaattgtt gggcacttgt atttgcattt gtaattttat aagcttgata     60

tcataacttc gtataatgta tgctatacga agttataggt                          100


<210>  11
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  11
cttcataact tcgtataatg tatgctatac gaagttatgg atccgagctc tctatccaaa     60

tagacatttc tttttttaat gtttgctggg ttcttacgca                          100


<210>  12
<211>  5246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5 homology arm

<400>  12
ctcagatgtt cctgcaatca tgcctttgct ctgccaccat ggactctggc tctaaaactg     60

tgatccccag gttaagggct ttcttttata aattgccttc actgtggtgt tatcacagtg    120

ataggaaagt gactgaaaca gacagtaaat gctgagatag gacagttgtt tatgccagag    180

ctgggccata gtaagaaaaa cctggacccc tgaaactgat gggatgacat gggatgggat    240

ggcatgagac aggataacat gggatggggt agaagggatg agaggagaaa gggtaggatg    300

agagaggaag ggagaggagg ggaagaatgg gaagggaggg gatggaatag gatgagagag    360

gagaaagagg aggagagggg aggggaggga ttgaatgaga agggatggga tgcgagtctt    420

gattttccag atcgtccttg aaccattagg cctacagaat tggaccacac atttaaaggc    480

ctcacatgat gtgtcctata aggcaccact aaccccattc ccctcctggc catcaaacct    540

gttactagag ccaattctca aggtgactca actggttaag tactagagag gttaatgtgc    600

caagtatcgc aggctcaggc tcgtgctttg aaagctcagt ccccagttaa tgataatgct    660

ttaggtggct gtggaattgt tagggggtgt ggctaagctg tcagatccag gaagtcacaa    720

ggttggaggg gtgcagcaat aatccactgt gagatagaat gaatgaactc tatgtgggag    780

atgaatgcca ctgctactgg agttcatacc caagactctt aagctgtggt ggtttgtata    840

tgctcagccc agggactggc actattagaa ggtgtgaccc tgttgagtag gtgtgtcact    900

gtgggtacgg gctttaagac cctcatccta gctgcctgga agccagtctt ccactagcag    960

ccttcagatg aagaggtagg actctcagct cctttggcac catgcctgcc tggatactga   1020

catgcccttg tcttaatgat aatggactaa acctctgaac ctgtaagtca gccccaatta   1080

aatgttgtcc ttataagagt tgccttggag gctggaaaga tggctcagtg gttaagagta   1140

ttgactgctc ttccaaaggt cctgagttca attcccagca accacatgat ggctcacaat   1200

catctgtaat ggggtctgat gccctcttct ggtgtgtctg aagacaccta cagtgtactc   1260

atataaataa aataaatctt aaaaaaaaac aaaaacaaaa acaaaaaagt tgccttggtc   1320

atggtatctg ttcacagcag taaaacccta actaagacag aagtcatcta tcacttcttc   1380

accctcagat cagactgtgg ctggctacat agcaagctac tccctaagca acggctggaa   1440

gaggagggtg aagctgagct ttgttgtcaa atctcacctg agcatgtgag tgaaagtcaa   1500

atatgaaaag ctgcaactgt gcagctccac tcatggctga agacagccat aagaggagac   1560

cctcccactg gcagggacct ggcattgtac ctgatcatct actttatatg ggaagggaaa   1620

tggcctaacg tcctcagaca caccagaaga gggcatcgga tcccattaca gaggttgtga   1680

gccaccatgt ggttcctggg aattgaactc aggacctctg gaagagcagc cagtgctttt   1740

aaccactgag ccatctctcc aggcccccac ccccaccacg agacctcact cctaactaag   1800

gagctattga cagttagtga ccactaagag aggaagaaca cttttctttg ggggtgcctg   1860

cttgtaggtt ggccttgccc cagtggatga ccttacactc actcacttcc acactcatgc   1920

acccctgatt aggatttact ggactcagag gactagtaat aataattggg gaagacaatt   1980

taggtggata aaatctaaat acattatatt catgttcaaa attttcaaag acaaaataaa   2040

aagtttaaaa gaaaacttct ggagggctgg agagatggct gactgctctt ccagaggtcc   2100

tgagttcaat tcccagcaat cacaaccacc tgtaatggga tctgatgccc tcttctgttg   2160

tgtctgaaga cagcgacggt gtactcatat acataaaata aataactaaa tctttaaaca   2220

aagaaaagga aaggaaagtt ctggttagag agatgcctca gaggttaaga gcactcgatg   2280

ctcatataga agccccgagt tcagatccta gcacccacct ggcagctaac agcagtctgt   2340

aactccatct tccaggacct gatgccctgt tctggcttcc tcaggtactg cacacacatg   2400

atatacatac aatgcatgct ggcaaagcac tcgtgcgtat aaaacatctt ttttataaaa   2460

aggggtccat caatatcctg aagggactgt ttgaggatga gggaagcagg tgacggggca   2520

ctgtcacctg aactggatct gcgtgacact gcctaggacc cccagctgat agggttgctg   2580

ccccctgaga gtggcaaaca gccagaccat aggtatcacc ctcgggagag cctactgcct   2640

cacccaagtc cacaccacct ccggggacca gcttccatcc aactactggg taacgtgccc   2700

cttgccatgc cataactcaa gaaatcagag acagcgcttt actgctctcc tccctcctgg   2760

cggctctcat gctcttcctg acctctcttc ctcaatgtct ttaaggtttt tagaaggaaa   2820

aagtttaatt atggaagtga tacatcattg cttctcagac gtttggctaa catcaagtgt   2880

ggaagtaaga ccgtgcatgt attaaaacca atgaagagca taggagaggt gtataataac   2940

accacgcccc actcatccca ccactatgcc ttttctcagg ggcacaacca cctcaacgga   3000

ccccttcctc tgggcttatc ttcacatccc acaaagtgca cagacatcct ttgagttccc   3060

tgggaaacaa accttgaggt ggagatttgt gtgcaggtgg ctcgtgggaa tgcaggacac   3120

ctgcaaagga gagagggaag ccacaaggca gacagagaaa gtcaacttca gggagcgact   3180

tcagggagcg gcagctcaga ggcctctgct tgggcctctg tgctcatgag ctcactgcag   3240

ctctggttac catgcagcat ttcagcaggc agcaggtaac tgcactcaga gggtgggggg   3300

cgggtgaggg gggttgggga ggggagagat gtacggggga tgtctgaggg cagtgaaagg   3360

gagaaatcaa ggtggatatg atcaagatac attacataca tgtatggaat tgtcggagaa   3420

taaataaatc ttttttgaaa aaaggggaga gagcgccaga gagtgagaca gcaaggcaga   3480

aagcaaaccc caactcaaaa acaaggcgga aaggggactc agactccaaa ctaaggtaga   3540

aagggggatc gagaaagagc gcttagtatc catctctggc ctccacaagc acctcacacg   3600

tctgcacact caaactccat acatacatga aaagattttg taatttccat taattaattt   3660

atttactcat tttacatccc aatctcagcc cccctcctcc aagccccccc tccaagtccc   3720

cgcccctcag atagccgctc cccccacccc tccttcccct tcccatctga gaagagggag   3780

gtccctctgg gcactgagtc tgatactatc ccttatctgg agatgtgggt gggcaaaaag   3840

aatgtaagag tagaaactag ggagaagggc tgtgaagcac tgccttctag tagctgtggc   3900

agccagcagt ggatccacat gcaactgggc ttatcaacag tcaatcatgc attggggcgg   3960

gacttctggg gctctaagcc tttctactga actataggtt atagatggat tcagaaagaa   4020

aggcagccgt tttcttcagt cctgtaccca ctgaggagct cttcaggctc cttcagtagt   4080

tagttccaaa tccactgtca cacagctaac tctcgttaaa cccagtagat atatcaagaa   4140

gcggagccag agagatacct caacagataa agttgtttgt ggttaaaaac ctaaagacct   4200

gaattgaaac ctgggactca catgttagag agaatccctc aagctaccct cgacttccac   4260

acatgctgtg gcaagtctat gcccacacat atacacatat aataaatagg taaataaata   4320

acgtaaaact tttttttcgt aaaacttttt aataaaagac ttgtcgagaa agggagatta   4380

atcatcagaa agtgtgttac aattgtatga aattatcaaa gagctaagtc aataagcgtt   4440

ttttacaaag aaaaagattg ttgcttataa ctcaggaagt acttatgcta gattttaaat   4500

aataatgcta aaagctaccc tagtgggtgc atgagtaaag cccctagcat agtgtcagta   4560

caaagacagg agctatgtga ctctctcatt gtccagcaac tgcccagcat gtgcaatcaa   4620

aggccaggac ggctacatgc taaaaatcct gtctcaaaga aagaaagaaa agaaaagcaa   4680

gcccctcgaa gattattaat gagacggctc cactccatcc tgctgctcag acccaagggc   4740

accataacag aaggcagata ctgagtgctt caacgtcttc ctgcctccgc tggaggggtt   4800

atgcataagg aaggctccct cagtgtggag gtgctttgca cagggcacaa gtaggtgttt   4860

ttcacagcac tctcgggggc ttgctagagc cccccttgtt catccttatg ggaaggctgt   4920

gaggcgcgga tttcctcagt taaccaaggc ggaggcttct gcctcaaaca tttccaagtg   4980

acgtggagca ggcgggccct gagtcccctc tacacttcct gtgtggggtt cagacacctg   5040

cctcccctgt ctgcgtctgg tgccttcttc agaaatggta agtctctcct tgtgaagtgc   5100

cccccactct ccttcatcct actatggcaa ccaatgatcc agggtctttg catgcagcca   5160

ctgtgttgaa aacctcatct gtttcttttt cagaagtaat gagctggctg cgtccgccat   5220

cttggtagag agagcattct gagagg                                        5246


<210>  13
<211>  3547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3 homology arm

<400>  13
aagtgctgct gaacagagcc agggaagacg agaaaagccg tgcgtgcgtg cgtgcgtgca     60

tgcatgcggt tccctcctgc cctggaggca gctgtctgaa gccccaagca gtagtggtta    120

tacagcagga tgtgggctgt gctgggagtg aggatgagag aggtgtggtg gtagccacgg    180

accagacact ggaggctatc gatgagagaa tgtggtcctt ggtctcccac atactctgct    240

tgcaggagag aggaacccag agcccaagca agctatccta ggccagctca agccatcgga    300

ctctcttctc cacctttctg ccctcagaca catccctgct gacttaaggg ctatttgtta    360

tgtgacttta gcttctgtgc ctagcagcgg tccacacact gtccatactc tgccttggat    420

ttgtaactac agttcctgct agttggtctc cactaaactg tcaccttttc ctctctaggc    480

atcgatgctt atgttaaaat gagtcttgat gattttgcct atcaccaaac actaataagc    540

aggtggcaga ttttgtcctg catatatttg atgtgtccag tcaaggacat tcgtagctca    600

acatgataaa aagcattaac atttggtgtt tactgagaat ttaccatgct ccagaagttg    660

ttatagccct atatgtgctg tctcatttaa tccttataga gacgccacaa atatatgttg    720

tcatcttcta tatagtgggc tcagagaggt agcatcattt atccatgtga agtgaaatgc    780

agggctacaa ttagcagcta gagatgtcta attctggggc actttttttt ttttttttgg    840

atacagagtc tcactatgta gctctggctg tcctagaact atgtatgtat gaactaagca    900

tgtagactag aaactatgta gaccagactg tcctcaaact cacagagatc ctcctgcctg    960

tgcctctgct tcccgagtgc caggattaaa agtgtgcact agtaatgctc tgcttctaac   1020

tccagcactc tggcacctac ccactatgac cgagaccatg gcaatgttct tcttcctacc   1080

atatgcctct ggaaaaaatg gaggagttgg agatggagca gaaacctaga gtctgttttc   1140

tatatgggtc ggaggcagga tacaatagga tgaaggcaga tgccgtgtca aggaaagtga   1200

gggtcatgca aaacacagct cttactccaa atagaatagc agttagttta ttctggagcc   1260

agcaagatgg cttagcaggt gacagtgctt accaccaagc ctgaagaccc gagtttgatt   1320

cccagaacct acctggtaga agaaaaccaa ctttcataaa ttatcctctg actgctaacc   1380

ccaccaggct agaagagcac taccacaatt tatgagccaa atttgaagca agctttttac   1440

tggccaagtc tatggatact ggccagatcc atacgcacta tctatcccca gagctccagc   1500

cctttataag gcaggggcta taaaggcaaa gcccataaga ctaccgactt cttcccacct   1560

tcatctagtc agggacaagc atacaccctg ccacactttc tgcctgtgaa cctgctggca   1620

atgggtaagc aagcacatcc tgtgcagctg gggcaaccca gcttctttat agaagcaaaa   1680

actcccggct tgttatcttc catgatcaac agcccccagc atcccaggaa gttggctgtt   1740

cttgagcaag tggggcttac aggttagagg cattttgttt aatagttaga tctcttaagc   1800

acagtaactt atacttagac ataatgttag cctcttgcgc gcgccggact ggccagcagt   1860

aacaacgctg caacaggatc cttctgcaca tgtttattgg gagagcttga ttgtagaggc   1920

gaagagaccc cgagcccaga actggtgctg cttatatagg cctaggagat gcgtgtctca   1980

cacccggatt ggctatgcac tacgcctcat ttgcatgttc ctcatctgat tggctactct   2040

ctctctctct gtacctcaca gagcctcatt atcatacctc atttgcatgt ctcacatctg   2100

attggttata ttctcaaagc ttcattatca tgcccgggcc aggcagtgtc tttgcaaaaa   2160

actttactgc atatgtacac attggttgtt tgtccaaact tatgcgtggt ggccagcagt   2220

agtcagcgcc actctgcaac ggcacatgtg gcttcccaca ttagccatca tatttctttc   2280

ttgagctgtg tatcctgagt caaatccttg actctaaagt gggtagcggc tcaaattaag   2340

atctaataac catcagctta atggcaccca gacagcaatt tacatatata gttaagatat   2400

taatgatgca aggttattag taactagcag aaacagaagg gcaaaggcct tgtgatggct   2460

gacagcagaa ctactaccta agtggagccc aaaaatgaga atgggagcca gtcatttgtc   2520

tcatcttggg gcctgttttt ctgtaggttt gggtttgctt tgttttgttt tgttttgttt   2580

tggaggggtt gtttgttttt ttagtacatt cagactatct cttatgattt cctgagtggt   2640

ttgcaaagaa gcaacaattt ttttaaacca tacaataacc tcattttaca tagagcaggt   2700

cgagtgtcct atcatgttct atcatatttc agctaataaa tctacttgtt aatagatctg   2760

ggtctatttg gctttagcag gtacctatcc tcatatgtca ataggctcta taggtgccta   2820

tttgtcctat ataccgtgga gtttcctttt aatctaacct tccagccttt tgtagagggt   2880

aaagggtaat gtactctctt ctttaactac ttcctgtgga aattaggaca tcactgacag   2940

ggctcaggaa ggctggaatg ctagtcaaag gccaggaggg gattcagcag aagcattggg   3000

ttagctggcc cagctgaaga gacagggagc aactatatct gctggactgt tttgtccaca   3060

tcagcattca gcaagtccag ggcttttagt cacttggagc aggttgtgta gtccacagct   3120

gattcctgga tggtgtttgt cagccaagtg gaaattcagc tgggacaggt atagaccacg   3180

gacagaagtt taccagtgtt tgtaatttgt gcttaaaatc cacgttgtag aaagggcagc   3240

tggcaggtgt ctgcaaaaca tctggagtgg actcatgcct ttgagtcata gagaaagctt   3300

tcacttaaaa agcttgaaca ttctttttct gtccagtggt ctaggtatag tgatgcgaaa   3360

tacctttaaa tctacactta gaagacaacc aaaggaattt aaaaccttga gctcatggct   3420

gataatggca gtcagcgctt ttgcagctta tcagaactcc actgatgaag gttaaaactc   3480

tgaacgtttg gaaccttagc atgatgacaa catagcaaga aggaaaggca tctgaaacat   3540

ttcttgt                                                             3547


<210>  14
<211>  10590
<212>  DNA
<213>  Homo sapiens

<400>  14
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagg tgagtaggat     60

ggagtggaaa gggtggtgtg tctccagacc gctggaaggc ttacagcctt acctggcact    120

gcctagtggc accaaggagc ctcatttacc agatgtaagg aactgtttgt gctatgttag    180

ggtgagggat tagagctggg gactaaagaa aaagataggc cacgggtgcc tgggagagcg    240

ttcggggagc aggcaaagaa gagcagttgg ggtgatcata gctattgtga gcagagaggt    300

ctcgctacct ctaagtacga gctcattcca acttacccag ccctccagaa ctaacccaaa    360

agagactgga agagcgaagc tccactcctt gttttgaaga gaccagatac ttgcgtccaa    420

actctgcaca gggcatatat agcaattcac tatctttgag accataaaac gcctcgtaat    480

ttttagtcct tttcaagtga ccaacaactt tcagtttatt tcattttttt gaagcaagat    540

ggattatgaa ttgataaata accaagagca tttctgtatc tcatatgaga taaataatac    600

caaaaaaagt tgccatttat tgtcagatac tgtgtaaaga aaaaattatt tagacgtgtt    660

aactggttta atcctacttc tgcctaggaa ggaaggtgtt atatcctctt tttaaaattc    720

tttttaattt tgactatata aactgataag tcctctctac ttcacagatt aagaaattga    780

tactcaaaaa agttaaataa cttgttttaa accacatagt aagtgccgaa gccaatctgt    840

gagaccagga ctgtttgtac tctaaatggc tgcaccacat gaggcaaaat ggctcgtgat    900

ggttttattt caaagaccta gaaaacacta tcacagctgg tgctcccgtc tcagacccac    960

agcaacgatg tctccacttc ctgcttcatc ttgggtttct cacgtcttga atgtgcacac   1020

aaatcacctg gggatcttgt taaaaatgca gcttctgttt caaaagaccc agactggaaa   1080

tggagattcc gcatgtctag tacgctctca agtttattaa tctgctgctg gtcctaggaa   1140

catattgagt agcgaggggc aggatgtgac tcctgtaagg agtggccagg cattttctta   1200

gagacctgtg ttataaagta tgcttttcct taaaaaaaag aagaaggagg aggaggagaa   1260

gggccaggtg cagtggctta cgcctgtaag cccagcattt tgggggacca aagtgggaag   1320

atcacttgag ctcaggagtt caagaccagc ctgggcaaag tagtgaaacc ccatttctac   1380

aaaaaattaa aaattagcca ggcaaggtgg cacacaccta tagttccagc tacttgggag   1440

gctgaggtgg aaggatcact tgagcccagg aggtcgaggc tgcagtaagc catgatcaag   1500

ccactgcact ccagcctgga gtgtctcaaa atagataaat aaataaataa ataaataaat   1560

aaataaataa ataaaagaga cagtatcaaa gacccaatca cctctagaca tctggcatca   1620

taggaatgtg cccagtctgc tctggggata ggaaagtggg gatcctgtct ccccctgtgt   1680

agaggtttca gtaaaagaaa ggcctaggtg tgcagaaagc tttcaggcaa tgccagggaa   1740

actgatcatt gtaatgaatc cagggtattg ctgagtgagg gcatcctgga gggcccggtg   1800

gaaatgtggt caggctcttc aatgcacagg ccctagttga tgagtaatca gggtttcaaa   1860

tatttccatc tctgtctcaa gcagaaaaca aatggaaaaa ctgaaccacc agaaaagcag   1920

agccagagat ggaacaagaa tcccagtgtt tgtacccaac caagagcgtg tttttcttcc   1980

acagacacca atgttcaaaa tggaggcttg ggggcaaaat tcttttgcta tgtctctagt   2040

cgtccaaaaa atggtcctaa ctttttctga ctcctgcttg tcaaaaattg tgggctcata   2100

gttaatgcta gatgcttcct tcctctattt ccccccaaat ttcctgggaa cccctggtca   2160

ataccagcag taagttccac tgttctaggg tgtagaaatg gctgtgaccc agcagcaaga   2220

gggaaggaca tcagatgtca tcagtggtca tactgcaaca cagccctttt tctgtttagg   2280

aatgcaggta cccacaacat ttactaacac tttttttttc ttatttattt tctagttggc   2340

gtttgggggc aagatggtga gatatgcttt ctttctttct tttttatgaa atcaccccat   2400

cattctttgt agttatgaat ggagctttct cttaggcctc ccacagaact tccacagagg   2460

tcaggaaaag gagtttctgc catctacccc tttgactttc ctcacaagtc tggagatatt   2520

tctagcccag aagagggaag caacagaggc aggaaataat gagtcttaac catacaaaag   2580

aaaaattgag acttaaatga agttgaaagc actaacagtt ttcatttgtt tgcatttcat   2640

atttgatgtg agattctgca gaggagacgt agccagaatg catgcacagg gttactctgg   2700

ataagctgct ggggcaacat ttggatgtgt gttcagaatc acatgtctga atactctgaa   2760

tatatgtgtg tacatgtgta tttatgcaag tgcacatgca tatgagtgtg cccggcctga   2820

acttactctc tcaaccacag cggtagagtc aggagtgttc caacattgga agcccctcta   2880

ttcaatcagc tcttccaaac tgagtgaacc aatgttgtat ttaatggcaa ccatggctgg   2940

acaccatggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg cagatcactt   3000

gaggccagga gttcgagacc agcctggcca acatggcgaa accccgtctc tactaaaaat   3060

accaaaatca gccagacatg gtggtgtacg cctgtagtcc tagctactcg agaagctgag   3120

gcaggagaat cgcttgaacc tgggaggcag aggttgtagt gagccgagat cacaccactg   3180

cactctagcc tgggtgacac atcgagactg tctcaaaaat aaaataaaga caaccattat   3240

gccagcctag attccgccat gctgcctaat ttgtagtgtc cttaggagcc atttttgtaa   3300

atagtcatca gataagatgt aaggcccata acagcttttt ctatgcagct gagggaattg   3360

gaagatccat tgtttcctaa gagttgaggg aagagtccca acccacggga gcagggtctg   3420

atcttcattg ccgatagaaa cattactaat ggcttcttac tgtttccttt tcaggtaatg   3480

aagaaatggg taagaagatt tccactctat ctagcaaaag ttttcaaata tggaatgaaa   3540

tgctcataga gtacaatcac agtaacaaac cctgagaact aaaactatta aagggaaaat   3600

acaagtatct ttcaatggga tccgtatgaa acttgcctgt atttgttgct agctgtcatg   3660

tcagattata gctgtgcata tatgtatctc tgatcataca catatggatg tgggttggag   3720

ctaccatgtg tttttgtata agccatgaaa tctttgaagg cagacagaga cagtgtctca   3780

tttacctagc ccagtgtctg gcacatagta ggtgctcaat gaatattttt tgaatgaata   3840

aatgaacaaa catatgaaca cattgctaat tacctcccct caagaagctg atggtcttgt   3900

gtgagagaca aataattgaa aatatagtga gttgcatgtt ataatatggg tagatacaga   3960

gtaaaatgaa gtataaagag gggagtggtc aactctactg agtgtcgttg ggaaaggttc   4020

cctgggggag gtggtccttg agctgaattt taaaggataa gcttatgttt tagggaagaa   4080

aaatatttta tgcagaagag ataaagctgt atagtatgag gataagagtc taactgagct   4140

agatcagaat gtttgaatct tggctcaact ctctacttgc tgggtgtgtt tgagtaattt   4200

acctaacttt tctgtgccac agcatcatca tggtacaatg gaaataatag tgctacctaa   4260

cttgtagggt tattatgagg accaaatgag taattcattt aaggcactta gaacattatc   4320

tgacataaaa ggcagtagga gggccgggca tggtggctca cacctgtaat cccagcactt   4380

tgagaagccg aggtgggagg atcacctgag gtcaggagtt cgagaccggc ctggccaaca   4440

tggtgaaact ccatctctgc taaaaataca aaaattagcc aggcatggtg gcaggtgcct   4500

gtaatctcag ctactcagga ggctgaggta ggagaattgc ttgaacctgg gaggcggagg   4560

ttggagtgag ctgagattgt gccattgcac tccagcctgg gcgacagagc aagactctgt   4620

ctcaaaacaa acaaacaaac aaacagacag taggtgaatt ttagctatta atacatggaa   4680

agcatgctga ctatagatga taagcattaa agtttactga gcatgtatgt tttaggcatt   4740

gctctaaata ttttacttga atttcctcat ttaattcttc caacacccct actgtacagt   4800

taaggaaaca aagcctcaaa taaatacaga aataaacaaa aataagtaaa caatccagtc   4860

ctggggatat aaatgcagat ttaggccaag tgccatggtt catgcctata atcccaacac   4920

tttgggaggc caaggcagga ggctcgcttg agctcagaag gttgaggctg cattgagcaa   4980

agattgtgcc actgtactcg agcctctgtg gcagagaaag accctgtctc tgaaaaaatt   5040

aataaataga aatttaaaaa taaaaaaatt ttaatgcaga tttatatgat accgaagttc   5100

attttctcaa ccattatgaa atactgtttc tggatatgta taaaatcttt gtgagcacac   5160

atatcttttt ttaacttaac tttcatttta aattcagggg tacatgtgca ggtttgttat   5220

ataggtaaac ttgtgccatg ggggtttgtt gtatagatta tttcatcacc caggcattaa   5280

gcctggtacc tgttagttat ttttcctgat cctctccctc ctcccaccct ccaccttctg   5340

agaggtccca gtgtgtgtca tttccctctg tgttcatgtg ttctcatcat ttagctccca   5400

cttctaaatg agaacatgtg gtatttggtt ttctgtcact gtgttagttt gctaaagata   5460

atggcctcca gtcccatcca tgttcctgca aaggacgtga tctcattctt ttttatggct   5520

gcgtagtatt ccatggtgta tatgcagcac atttttttat ccagtctacc actgacaggc   5580

atttaggttg attccatgtc tttgctattg tgaatagtgc acaatgaaca tacgtggagc   5640

acatttctgt ctaagcacag acatctagac ccttgtgtga gcatgagtta agtctaagct   5700

ctgctactga atttgtgcca ataaaagttg tgagcaattt tctttacatt tttttcaaac   5760

aaacacaccc agcagagtat aatgtctatg tactttattt atgatttcta gttcatttaa   5820

catgtctaag aaacatccgt gttgaaaaat tatttataaa ttaaaataat ataaactatc   5880

tactgtcctt atactcaact cccaattata agcaggtgga aaaacctgga gaatgttttg   5940

tttacattct gtgcagtctt tgtcagaggg ctgcctgagc aactgggtca gagtttagtt   6000

ctgctctggg agtagcagga cctcaagaag gaaaggagga aaggaagtaa ctttttcttg   6060

agcacctgct atgtgtcatt cactttcacc ttcataatcc atttaatttt cgcaaaaact   6120

ttgtgaggtt ggtgttttat ctccatttcc ctgataaaga agttgaggtt cagcaaagtt   6180

aaatgacttg ccctcagtca cacagactag ggcagatcca ggattcaaac tcagggcttc   6240

tgactcttga gtccagagct ctgtccctga cagcagcagc actgcctctc ctctcttcca   6300

gctgttatgt ccagactgta gcagaaccca gtgttccagc cacaagtttt ccaggaaata   6360

ataaaggact cctagctcca cctcccaggg caaaaatggc tgctgtggga aacacaggct   6420

ggacctacga atggcattag tggtttatta gttgatttca gttgtccaca ctaataggcc   6480

tccctctaac aaaaataatt gagagctgat tatgctcaga tataatgtaa agtgaagcca   6540

ctttttattg gaagaagcat tccctcaaaa cgtgtagagt atttcacatt atttaaaggc   6600

aaatagagag aaaattatat ggaataagaa caaagatgtt tcttctctat tatgagggac   6660

tcagttctga gaaaggattt taaattgtaa gaaataggta agtccacgaa tcagtgattc   6720

agtggtgtgg agagctttat ttctgagaag gccagtagcg ctcccttctg acaagcaaat   6780

ctaagacctg gatgacagat gacttcctgc atttggttgg ttcttttgtc attcatatct   6840

atctgtaata cagttctggc taatttaaga ggataagctt gaagacctct ggaatttttc   6900

ggctttagga ctttaaggct ttctgagctt cagtagatct agatctagga gctcatgctg   6960

gtatattctg aatccgatgt atctgagtta catctatgag ctacttaata aatatatcta   7020

tgagctaaat ctcataggct aagcatgaac ctcacctcca agactcgggg ttcctaaatg   7080

gatgagaccc tctttgggaa gtcttgtggg cagtgtctaa ttccactaga aaagttttac   7140

ctacaattta aacttaaacc atgatatttt cttactgctg tttccttttt tcattttcag   7200

gtggtattac acagacacgt gagtttattg gtcttttatt tatgccctgt ctgaggatgc   7260

agattggtgg gtagatgaga aggaactgat tgagagagat taaccccaag aactgatatc   7320

ttcccagcat tgcattctca actccatttt agaaaggttc caaataggga cttctgtggg   7380

tttttcttta catccatctt acccttccca agtccccatg tccctgcgta aaccctaaag   7440

ccacctctca aaaggttctc tagttccctt caaggttctc tagttccctt cattccacat   7500

atctcctctt ccacaccctc tagccagtag agctcccttc tgacaagcaa gtctaagatc   7560

tagatgacag atgacttcct gcatttgggt ggttcttttg tcactaattt gccttttcta   7620

aaattgtcct ggtttcttct gccaatttcc cttctttctc cccagcatat aaagtctcca   7680

tctctggaac cacagtaata ttgacatgcc ctcagtatcc tggatctgaa atactatggc   7740

aacacaatga taaaaacata ggcggtgatg aggatgataa aaacataggc agtgatgagg   7800

atcacctgtc actgaaggaa ttttcagaat tggagcaaag tggttattat gtctgctacc   7860

ccagaggaag caaaccagaa gatgcgaact tttatctcta cctgagggca agaggtaatc   7920

caggtctcca gaacaggtac caccggctct ttagggagga ccattcaaaa gggcattctc   7980

agtgattttc cctaacccag ctcacagtgc ccaggcgtct ttgcgcttcc tcccacactc   8040

aatcctggga ctctctggta ccacacggca tcagtgtttt ctggaatata gattaaacac   8100

caatatgagg cttctgggta accccagtct gtgcgagatc taaaatagca actccctaag   8160

agacaggact gggtcatttg caccgcatca cacccaggtt catagcacac caacatgagt   8220

ttatctaatg cttcctccag agataaattt ttcagaaagg tttgcaaaaa acactcaagg   8280

ccactatagt aaaatggcat aagctaaggt ataataataa aataataaca atacttaaca   8340

tttattgagt gcttattaag tctcaagcac tgtctgtacc caacacttat caaggattct   8400

ttttcatgta atcctctcaa caactatatg ggttaagtat cattttattc ccatgagtaa   8460

agggatgagg aaacagaggg tttgtgagtt gaaaacacat ttcacgcttc tcacagctag   8520

tgagtaataa agctgggact caaacccagg gctgtttgac tccagtgcct ctacccacgg   8580

ccaccactct ttgcttgtca atgttgttct aaacatattg aagggggggc tctgaccgtg   8640

gcaagcgtgt gagtagtaag gggagaatgg ccttcatgca ctccctcctc acctccagcg   8700

ccttgtgttt tccttgctta gtgatttccc ctctccccac cccacccccc acagtgtgtg   8760

agaactgcat ggagatggat gtgatgtcgg tggccacaat tgtcatagtg gacatctgca   8820

tcactggggg cttgctgctg ctggtttact actggagcaa gaatagaaag gccaaggcca   8880

agcctgtgac acgaggagcg ggtgctggcg gcaggcaaag gggtaaggct gtggagtcca   8940

gtcagaggag attcctgcca agggggacga ccagcctggg ccagggtggg tggcaagtcc   9000

acagctaggt cagaacagct tctctagagc ttctatgcac agcttctatt actgtgatga   9060

caagatctca acagacggtt tcaaatctca catcactccc ctccttccca tcctagaaaa   9120

gtgcaaaaaa gtttatgaaa gtgatgggct tcctcacata cctgtcaatg cctgcagtca   9180

tccgattccg cccctaagct gtgggaagag agactttgat atattagctc ctgccttttc   9240

ctttcccttc ccctatggag agaaacaatg ggaggatctt gagctgagga aagtcacaaa   9300

atgatgagaa gagtgtaggg tccttagaga tgaatgaaag aaaaaaaaag agaaaggacg   9360

tctgaacaga aaagggagcg gtagaggaga gaacaatggg gtttgccatt ctctatctgg   9420

gtctcactgg cacagacagt gctgcaagat tggttccctc atgggaatga aatgtttccc   9480

ctccttcctc cgcaggacaa aacaaggaga ggccaccacc tgttcccaac ccagactatg   9540

aggtaacgtg ggatagaaat gggccaggac gctggagggg atgtccctcc aggggggaag   9600

gaaacagatg ggatggccca tcttgtctgc cagatgcctc aaagcccctc actcagggct   9660

tccattacaa ccctctatgt gccacctctg cgtccttcat ggtaaaacag gactgtctca   9720

aaggctgcat ggcttccaca accatggaga ggtggaagct tgcaggagac atactcctct   9780

ttctctggct tattcattga ctgggataca gccatggaga atattatata tgcaaattct   9840

aacacaataa attctgggct gatattccac cagcatgcac cagtatagcg agttattgaa   9900

atattaaaat tatataaata ttatataaaa gttattgaaa tattaaaata ctcattggga   9960

aatagcccca aactttgctc accccaaccc acccttacac acacacatac acacacacac  10020

acacacacac acacacacac acacacacgt gaccagacat cccagtccct cccctaccgg  10080

gctgcctctt gagttggggt aacaaagagt taatgcctgg catggcagag gatcaccagg  10140

attgttctag ttgattggta tgtgtgcact cctagttgtt aaatattttc actatcacac  10200

ctggatatac tcaacaaata tttgttgagc caaatactca acaccagcca aacacgtagt  10260

atttacttta gcttaagcga attatttagc cctgacagaa gccctggaat gtgggtcttt  10320

aagttcctat ttttgagatg ggaaagctga ggctcacgga aggaggtgac cagctcaagt  10380

ctcctaccgt ccatgccaaa ttagaattcc agcctgcctc ctgacttcaa gtccaaagtt  10440

cttcccacgc actaaagcta gctcttcagt gtcctttctt aggaggtact tcctcccgca  10500

ccactgaccg ccccctctct atttcacccc cagcccatcc ggaaaggcca gcgggacctg  10560

tattctggcc tgaatcagag acgcatctga                                   10590


<210>  15
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  15
ggaaaggcca gcgggacctg tattctggcc tgaatcagag acgcatctga cagataggag     60

agacatcgcc ttctgtggac ccagatccag ccctccgagc                          100


<210>  16
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  16
tggtgaggaa ggaattgggg ctgagaagct ggtttccatc agctgccagg aagcttgata     60

tcgaattccg aagttcctat tctctagaaa gtataggaac                          100


<210>  17
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  17
aaagtatagg aacttcatca gtcaggtaca taatggtgga tccagaattc aagtgctgct     60

gaacagagcc agggaagacg agaaaagccg tgcgtgcgtg                          100


<210>  18
<211>  1511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the CD3E mRNA sequence of the transformed humanized mouse

<400>  18
agacacctgc ctcccctgtc tgcgtctggt gccttcttca gaaatgaagt aatgagctgg     60

ctgcgtccgc catcttggta gagagagcat tctgagagga tgcagtcggg cactcactgg    120

agagttctgg gcctctgcct cttatcagtt ggcgtttggg ggcaagatgg taatgaagaa    180

atgggtggta ttacacagac accatataaa gtctccatct ctggaaccac agtaatattg    240

acatgccctc agtatcctgg atctgaaata ctatggcaac acaatgataa aaacataggc    300

ggtgatgagg atgataaaaa cataggcagt gatgaggatc acctgtcact gaaggaattt    360

tcagaattgg agcaaagtgg ttattatgtc tgctacccca gaggaagcaa accagaagat    420

gcgaactttt atctctacct gagggcaaga gtgtgtgaga actgcatgga gatggatgtg    480

atgtcggtgg ccacaattgt catagtggac atctgcatca ctgggggctt gctgctgctg    540

gtttactact ggagcaagaa tagaaaggcc aaggccaagc ctgtgacacg aggagcgggt    600

gctggcggca ggcaaagggg acaaaacaag gagaggccac cacctgttcc caacccagac    660

tatgagccca tccggaaagg ccagcgggac ctgtattctg gcctgaatca gagacgcatc    720

tgacagatag gagagacatc gccttctgtg gacccagatc cagccctccg agcaccctgc    780

tactccttgt tctctggaca gactgcagac tccacagctt gctcttcagc ctcctggtga    840

acacgtgtcc tagaaccttg ctctcctgcc tcctctgcta gtagccagtg ctgggacatt    900

gctgactcaa cagcctttga aagaatcagg ctgctcagat tgtctgccag ccaccttgtg    960

gggatacttt tttcagccgc cctgctgcca gctccccgct gcctcaccag tgtcctctct   1020

gcctcagttc ctttcctctc ctaattggcc ctcatagcta agccctttcc tacagctttc   1080

tgttttttct ttttctttct ttttaggttt tctttctttt cttttttatt cctttttatt   1140

taatcttttt tttttaaaca ctccagattt tattcccttc ccggcccatc ctccgactgt   1200

tacacacccc atacctcctc cctgccccct tgtctctacg agaatgtccc ccacccccat   1260

cccccacctg ctttctggtt tttggttttt ggtttgtttt ttttttttaa actctgtgtt   1320

ttacactctt ctctgggatg gattctgtaa tcattggcac aggtcctgcc ccatttatag   1380

atcctggccc agcccctgcc acaggtgcct ctccagattt ccccttagat cctcggatgg   1440

tcatctccat ctccatgaat acaccagccc cctctctgct aatgcaaaag gcaataaagt   1500

gtattggctg g                                                        1511


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   primer

<400>  19
acattgtgca acatggttcc tttatga                                         27


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
ggcaccattt tagcttcctt tcgcc                                           25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
ctcgactgtg ccttctagtt gccag                                           25


<210>  22
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
acccaaattc cttgttttca gttgcca                                         27


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
gagctacaca gtgagactac cacag                                           25


<210>  24
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   primer

<400>  24
cacagtatct gacaataaat ggcaac                                          26


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
gctcgactag agcttgcgga                                                 20


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
ctctcagtaa tcaacttctc gtgtgtc                                         27


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  27
tacagaacac atggaggcac ag                                              22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  28
gtaacaacgc tgcaacagga tc                                              22


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  29
cacactctca tatcactgta cacac                                           25


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  30
tgatggatcc aagagtgggc aac                                             23


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  31
tcgatgtagg agggcgtgga tatgt                                           25


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  32
tgtattgacc gattccttgc ggtcc                                           25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  33
gcttcaagga tgtttaactg caaag                                           25


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  34
tgcaacagat gtgctggcga                                                 20


<210>  35
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  35
tggtacgtgc ttgtaatcct aacactgtga gatatcgtgg ctcatgcctc taatcccagc     60

acttttggag                                                            70


<210>  36
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  36
gctgcgtccg ccatcttggt agagagagca ttctgagagg atgcagtcgg gcactcactg     60

gagagttctg gg                                                         72


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  37
ggatcggcca ttgaacaaga t                                               21


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  38
cagaagaact cgtcaagaag gc                                              22


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
gatccacacc attgcacaag ccag                                            24


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
tgctttgagt tgttggttga gtttc                                           25


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
aaatggggat cagaaaccct tcacc                                           25


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
atggcaacca atgatccagg gt                                              22


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
ctgagtcccc agcccttgtc                                                 20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
atgaggctcc ttggtgccac t                                               21


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
gcagtgcttc ctgttagagg aggtg                                           25


<210>  46
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46
ttctcgtctt ccctggctct gttca                                           25


<210>  47
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
tgttgggcac ttgtatttgc atttgt                                          26


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
gggattgggc tcaggttgtc acatt                                           25


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
gacgtgccct ctagacagtg acgag                                           25


<210>  50
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50
acacactcga gctttcaggt acaag                                           25


<210>  51
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
taggcagtga tgaggatcac ctgtc                                           25


<210>  52
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
cttgttttgt cccctttgcc tgccg                                           25


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
aacggtggaa ggatggtttg caaag                                           25


<210>  54
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
gcttgaacct cagcagcccc agaag                                           25


<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
aattgcaata ccagcatcac atggg                                           25


<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
atctcggagg ggctgataga cctgg                                           25


<210>  57
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
agcccagaca aataaagcaa agaat                                           25


<210>  58
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
gtcccgcaat gagatataca ccaag                                           25


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  59
ggcccagtca atcaaaggaa accac                                           25


<210>  60
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
ggagtggttt tgacttgttc tgtga                                           25


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
tcaccatctt ccaggagcga ga                                              22


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
gaaggccatg ccagtgagct t                                               21


<210>  63
<211>  8780
<212>  DNA
<213>  Homo sapiens

<400>  63
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagg tgagtaggat     60

ggagtggaaa gggtggtgtg tctccagacc gctggaaggc ttacagcctt acctggcact    120

gcctagtggc accaaggagc ctcatttacc agatgtaagg aactgtttgt gctatgttag    180

ggtgagggat tagagctggg gactaaagaa aaagataggc cacgggtgcc tgggagagcg    240

ttcggggagc aggcaaagaa gagcagttgg ggtgatcata gctattgtga gcagagaggt    300

ctcgctacct ctaagtacga gctcattcca acttacccag ccctccagaa ctaacccaaa    360

agagactgga agagcgaagc tccactcctt gttttgaaga gaccagatac ttgcgtccaa    420

actctgcaca gggcatatat agcaattcac tatctttgag accataaaac gcctcgtaat    480

ttttagtcct tttcaagtga ccaacaactt tcagtttatt tcattttttt gaagcaagat    540

ggattatgaa ttgataaata accaagagca tttctgtatc tcatatgaga taaataatac    600

caaaaaaagt tgccatttat tgtcagatac tgtgtaaaga aaaaattatt tagacgtgtt    660

aactggttta atcctacttc tgcctaggaa ggaaggtgtt atatcctctt tttaaaattc    720

tttttaattt tgactatata aactgataag tcctctctac ttcacagatt aagaaattga    780

tactcaaaaa agttaaataa cttgttttaa accacatagt aagtgccgaa gccaatctgt    840

gagaccagga ctgtttgtac tctaaatggc tgcaccacat gaggcaaaat ggctcgtgat    900

ggttttattt caaagaccta gaaaacacta tcacagctgg tgctcccgtc tcagacccac    960

agcaacgatg tctccacttc ctgcttcatc ttgggtttct cacgtcttga atgtgcacac   1020

aaatcacctg gggatcttgt taaaaatgca gcttctgttt caaaagaccc agactggaaa   1080

tggagattcc gcatgtctag tacgctctca agtttattaa tctgctgctg gtcctaggaa   1140

catattgagt agcgaggggc aggatgtgac tcctgtaagg agtggccagg cattttctta   1200

gagacctgtg ttataaagta tgcttttcct taaaaaaaag aagaaggagg aggaggagaa   1260

gggccaggtg cagtggctta cgcctgtaag cccagcattt tgggggacca aagtgggaag   1320

atcacttgag ctcaggagtt caagaccagc ctgggcaaag tagtgaaacc ccatttctac   1380

aaaaaattaa aaattagcca ggcaaggtgg cacacaccta tagttccagc tacttgggag   1440

gctgaggtgg aaggatcact tgagcccagg aggtcgaggc tgcagtaagc catgatcaag   1500

ccactgcact ccagcctgga gtgtctcaaa atagataaat aaataaataa ataaataaat   1560

aaataaataa ataaaagaga cagtatcaaa gacccaatca cctctagaca tctggcatca   1620

taggaatgtg cccagtctgc tctggggata ggaaagtggg gatcctgtct ccccctgtgt   1680

agaggtttca gtaaaagaaa ggcctaggtg tgcagaaagc tttcaggcaa tgccagggaa   1740

actgatcatt gtaatgaatc cagggtattg ctgagtgagg gcatcctgga gggcccggtg   1800

gaaatgtggt caggctcttc aatgcacagg ccctagttga tgagtaatca gggtttcaaa   1860

tatttccatc tctgtctcaa gcagaaaaca aatggaaaaa ctgaaccacc agaaaagcag   1920

agccagagat ggaacaagaa tcccagtgtt tgtacccaac caagagcgtg tttttcttcc   1980

acagacacca atgttcaaaa tggaggcttg ggggcaaaat tcttttgcta tgtctctagt   2040

cgtccaaaaa atggtcctaa ctttttctga ctcctgcttg tcaaaaattg tgggctcata   2100

gttaatgcta gatgcttcct tcctctattt ccccccaaat ttcctgggaa cccctggtca   2160

ataccagcag taagttccac tgttctaggg tgtagaaatg gctgtgaccc agcagcaaga   2220

gggaaggaca tcagatgtca tcagtggtca tactgcaaca cagccctttt tctgtttagg   2280

aatgcaggta cccacaacat ttactaacac tttttttttc ttatttattt tctagttggc   2340

gtttgggggc aagatggtga gatatgcttt ctttctttct tttttatgaa atcaccccat   2400

cattctttgt agttatgaat ggagctttct cttaggcctc ccacagaact tccacagagg   2460

tcaggaaaag gagtttctgc catctacccc tttgactttc ctcacaagtc tggagatatt   2520

tctagcccag aagagggaag caacagaggc aggaaataat gagtcttaac catacaaaag   2580

aaaaattgag acttaaatga agttgaaagc actaacagtt ttcatttgtt tgcatttcat   2640

atttgatgtg agattctgca gaggagacgt agccagaatg catgcacagg gttactctgg   2700

ataagctgct ggggcaacat ttggatgtgt gttcagaatc acatgtctga atactctgaa   2760

tatatgtgtg tacatgtgta tttatgcaag tgcacatgca tatgagtgtg cccggcctga   2820

acttactctc tcaaccacag cggtagagtc aggagtgttc caacattgga agcccctcta   2880

ttcaatcagc tcttccaaac tgagtgaacc aatgttgtat ttaatggcaa ccatggctgg   2940

acaccatggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg cagatcactt   3000

gaggccagga gttcgagacc agcctggcca acatggcgaa accccgtctc tactaaaaat   3060

accaaaatca gccagacatg gtggtgtacg cctgtagtcc tagctactcg agaagctgag   3120

gcaggagaat cgcttgaacc tgggaggcag aggttgtagt gagccgagat cacaccactg   3180

cactctagcc tgggtgacac atcgagactg tctcaaaaat aaaataaaga caaccattat   3240

gccagcctag attccgccat gctgcctaat ttgtagtgtc cttaggagcc atttttgtaa   3300

atagtcatca gataagatgt aaggcccata acagcttttt ctatgcagct gagggaattg   3360

gaagatccat tgtttcctaa gagttgaggg aagagtccca acccacggga gcagggtctg   3420

atcttcattg ccgatagaaa cattactaat ggcttcttac tgtttccttt tcaggtaatg   3480

aagaaatggg taagaagatt tccactctat ctagcaaaag ttttcaaata tggaatgaaa   3540

tgctcataga gtacaatcac agtaacaaac cctgagaact aaaactatta aagggaaaat   3600

acaagtatct ttcaatggga tccgtatgaa acttgcctgt atttgttgct agctgtcatg   3660

tcagattata gctgtgcata tatgtatctc tgatcataca catatggatg tgggttggag   3720

ctaccatgtg tttttgtata agccatgaaa tctttgaagg cagacagaga cagtgtctca   3780

tttacctagc ccagtgtctg gcacatagta ggtgctcaat gaatattttt tgaatgaata   3840

aatgaacaaa catatgaaca cattgctaat tacctcccct caagaagctg atggtcttgt   3900

gtgagagaca aataattgaa aatatagtga gttgcatgtt ataatatggg tagatacaga   3960

gtaaaatgaa gtataaagag gggagtggtc aactctactg agtgtcgttg ggaaaggttc   4020

cctgggggag gtggtccttg agctgaattt taaaggataa gcttatgttt tagggaagaa   4080

aaatatttta tgcagaagag ataaagctgt atagtatgag gataagagtc taactgagct   4140

agatcagaat gtttgaatct tggctcaact ctctacttgc tgggtgtgtt tgagtaattt   4200

acctaacttt tctgtgccac agcatcatca tggtacaatg gaaataatag tgctacctaa   4260

cttgtagggt tattatgagg accaaatgag taattcattt aaggcactta gaacattatc   4320

tgacataaaa ggcagtagga gggccgggca tggtggctca cacctgtaat cccagcactt   4380

tgagaagccg aggtgggagg atcacctgag gtcaggagtt cgagaccggc ctggccaaca   4440

tggtgaaact ccatctctgc taaaaataca aaaattagcc aggcatggtg gcaggtgcct   4500

gtaatctcag ctactcagga ggctgaggta ggagaattgc ttgaacctgg gaggcggagg   4560

ttggagtgag ctgagattgt gccattgcac tccagcctgg gcgacagagc aagactctgt   4620

ctcaaaacaa acaaacaaac aaacagacag taggtgaatt ttagctatta atacatggaa   4680

agcatgctga ctatagatga taagcattaa agtttactga gcatgtatgt tttaggcatt   4740

gctctaaata ttttacttga atttcctcat ttaattcttc caacacccct actgtacagt   4800

taaggaaaca aagcctcaaa taaatacaga aataaacaaa aataagtaaa caatccagtc   4860

ctggggatat aaatgcagat ttaggccaag tgccatggtt catgcctata atcccaacac   4920

tttgggaggc caaggcagga ggctcgcttg agctcagaag gttgaggctg cattgagcaa   4980

agattgtgcc actgtactcg agcctctgtg gcagagaaag accctgtctc tgaaaaaatt   5040

aataaataga aatttaaaaa taaaaaaatt ttaatgcaga tttatatgat accgaagttc   5100

attttctcaa ccattatgaa atactgtttc tggatatgta taaaatcttt gtgagcacac   5160

atatcttttt ttaacttaac tttcatttta aattcagggg tacatgtgca ggtttgttat   5220

ataggtaaac ttgtgccatg ggggtttgtt gtatagatta tttcatcacc caggcattaa   5280

gcctggtacc tgttagttat ttttcctgat cctctccctc ctcccaccct ccaccttctg   5340

agaggtccca gtgtgtgtca tttccctctg tgttcatgtg ttctcatcat ttagctccca   5400

cttctaaatg agaacatgtg gtatttggtt ttctgtcact gtgttagttt gctaaagata   5460

atggcctcca gtcccatcca tgttcctgca aaggacgtga tctcattctt ttttatggct   5520

gcgtagtatt ccatggtgta tatgcagcac atttttttat ccagtctacc actgacaggc   5580

atttaggttg attccatgtc tttgctattg tgaatagtgc acaatgaaca tacgtggagc   5640

acatttctgt ctaagcacag acatctagac ccttgtgtga gcatgagtta agtctaagct   5700

ctgctactga atttgtgcca ataaaagttg tgagcaattt tctttacatt tttttcaaac   5760

aaacacaccc agcagagtat aatgtctatg tactttattt atgatttcta gttcatttaa   5820

catgtctaag aaacatccgt gttgaaaaat tatttataaa ttaaaataat ataaactatc   5880

tactgtcctt atactcaact cccaattata agcaggtgga aaaacctgga gaatgttttg   5940

tttacattct gtgcagtctt tgtcagaggg ctgcctgagc aactgggtca gagtttagtt   6000

ctgctctggg agtagcagga cctcaagaag gaaaggagga aaggaagtaa ctttttcttg   6060

agcacctgct atgtgtcatt cactttcacc ttcataatcc atttaatttt cgcaaaaact   6120

ttgtgaggtt ggtgttttat ctccatttcc ctgataaaga agttgaggtt cagcaaagtt   6180

aaatgacttg ccctcagtca cacagactag ggcagatcca ggattcaaac tcagggcttc   6240

tgactcttga gtccagagct ctgtccctga cagcagcagc actgcctctc ctctcttcca   6300

gctgttatgt ccagactgta gcagaaccca gtgttccagc cacaagtttt ccaggaaata   6360

ataaaggact cctagctcca cctcccaggg caaaaatggc tgctgtggga aacacaggct   6420

ggacctacga atggcattag tggtttatta gttgatttca gttgtccaca ctaataggcc   6480

tccctctaac aaaaataatt gagagctgat tatgctcaga tataatgtaa agtgaagcca   6540

ctttttattg gaagaagcat tccctcaaaa cgtgtagagt atttcacatt atttaaaggc   6600

aaatagagag aaaattatat ggaataagaa caaagatgtt tcttctctat tatgagggac   6660

tcagttctga gaaaggattt taaattgtaa gaaataggta agtccacgaa tcagtgattc   6720

agtggtgtgg agagctttat ttctgagaag gccagtagcg ctcccttctg acaagcaaat   6780

ctaagacctg gatgacagat gacttcctgc atttggttgg ttcttttgtc attcatatct   6840

atctgtaata cagttctggc taatttaaga ggataagctt gaagacctct ggaatttttc   6900

ggctttagga ctttaaggct ttctgagctt cagtagatct agatctagga gctcatgctg   6960

gtatattctg aatccgatgt atctgagtta catctatgag ctacttaata aatatatcta   7020

tgagctaaat ctcataggct aagcatgaac ctcacctcca agactcgggg ttcctaaatg   7080

gatgagaccc tctttgggaa gtcttgtggg cagtgtctaa ttccactaga aaagttttac   7140

ctacaattta aacttaaacc atgatatttt cttactgctg tttccttttt tcattttcag   7200

gtggtattac acagacacgt gagtttattg gtcttttatt tatgccctgt ctgaggatgc   7260

agattggtgg gtagatgaga aggaactgat tgagagagat taaccccaag aactgatatc   7320

ttcccagcat tgcattctca actccatttt agaaaggttc caaataggga cttctgtggg   7380

tttttcttta catccatctt acccttccca agtccccatg tccctgcgta aaccctaaag   7440

ccacctctca aaaggttctc tagttccctt caaggttctc tagttccctt cattccacat   7500

atctcctctt ccacaccctc tagccagtag agctcccttc tgacaagcaa gtctaagatc   7560

tagatgacag atgacttcct gcatttgggt ggttcttttg tcactaattt gccttttcta   7620

aaattgtcct ggtttcttct gccaatttcc cttctttctc cccagcatat aaagtctcca   7680

tctctggaac cacagtaata ttgacatgcc ctcagtatcc tggatctgaa atactatggc   7740

aacacaatga taaaaacata ggcggtgatg aggatgataa aaacataggc agtgatgagg   7800

atcacctgtc actgaaggaa ttttcagaat tggagcaaag tggttattat gtctgctacc   7860

ccagaggaag caaaccagaa gatgcgaact tttatctcta cctgagggca agaggtaatc   7920

caggtctcca gaacaggtac caccggctct ttagggagga ccattcaaaa gggcattctc   7980

agtgattttc cctaacccag ctcacagtgc ccaggcgtct ttgcgcttcc tcccacactc   8040

aatcctggga ctctctggta ccacacggca tcagtgtttt ctggaatata gattaaacac   8100

caatatgagg cttctgggta accccagtct gtgcgagatc taaaatagca actccctaag   8160

agacaggact gggtcatttg caccgcatca cacccaggtt catagcacac caacatgagt   8220

ttatctaatg cttcctccag agataaattt ttcagaaagg tttgcaaaaa acactcaagg   8280

ccactatagt aaaatggcat aagctaaggt ataataataa aataataaca atacttaaca   8340

tttattgagt gcttattaag tctcaagcac tgtctgtacc caacacttat caaggattct   8400

ttttcatgta atcctctcaa caactatatg ggttaagtat cattttattc ccatgagtaa   8460

agggatgagg aaacagaggg tttgtgagtt gaaaacacat ttcacgcttc tcacagctag   8520

tgagtaataa agctgggact caaacccagg gctgtttgac tccagtgcct ctacccacgg   8580

ccaccactct ttgcttgtca atgttgttct aaacatattg aagggggggc tctgaccgtg   8640

gcaagcgtgt gagtagtaag gggagaatgg ccttcatgca ctccctcctc acctccagcg   8700

ccttgtgttt tccttgctta gtgatttccc ctctccccac cccacccccc acagtgtgtg   8760

agaactgcat ggagatggat                                               8780


<210>  64
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection sequence

<400>  64
ccacagtgtg tgagaactgc atggagatgg atctgacagc agtagccata atcatcattg     60

ttgacatct                                                             69


<210>  65
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   the CD3E mRNA sequence of the transformed humanized mouse

<400>  65
gcgtctggtg ccttcttcag aaatgaagta atgagctggc tgcgtccgcc atcttggtag     60

agagagcatt ctgagaggat gcagtcgggc actcactgga gagttctggg cctctgcctc    120

ttatcagttg gcgtttgggg gcaagatggt aatgaagaaa tgggtggtat tacacagaca    180

ccatataaag tctccatctc tggaaccaca gtaatattga catgccctca gtatcctgga    240

tctgaaatac tatggcaaca caatgataaa aacataggcg gtgatgagga tgataaaaac    300

ataggcagtg atgaggatca cctgtcactg aaggaatttt cagaattgga gcaaagtggt    360

tattatgtct gctaccccag aggaagcaaa ccagaagatg cgaactttta tctctacctg    420

agggcaagag tgtgtgagaa ctgcatggag atggatctga cagcagtagc cataatcatc    480

attgttgaca tctgtatcac tctgggcttg ctgatggtca tttattactg gagcaagaat    540

aggaaggcca aggccaagcc tgtgacccga ggaaccggtg ctggtagcag gcccagaggg    600

caaaacaagg agcggccacc acctgttccc aacccagact atgagcccat ccgcaaaggc    660

cagcgggacc tgtattctgg cctgaatcag agagcagtct gacagatagg agagacatcg    720

ccttctgtgg acccagatcc agccctccga gcaccctgct actccttgtt ctctggacag    780

actgcagact ccacagcttg ctcttcagcc tcctggtgaa cacgtgtcct agaaccttgc    840

tctcctgcct cctctgctag tagccagtgc tgggacattg ctgactcaac agcctttgaa    900

agaatcaggc tgctcagatt gtctgccagc caccttgtgg ggatactttt ttcagccgcc    960

ctgctgccag ctccccgctg cctcaccagt gtcctctctg cctcagttcc tttcctctcc   1020

taattggccc tcatagctaa gccctttcct acagctttct gttttttctt tttctttctt   1080

tttaggtttt ctttcttttc ttttttattc ctttttattt aatctttttt ttttaaacac   1140

tccagatttt attcccttcc cggcccatcc tccgactgtt acacacccca tacctcctcc   1200

ctgccccctt gtctctacga gaatgtcccc cacccccatc ccccacctgc tttctggttt   1260

ttggtttttg gtttgttttt tttttttaaa ctctgtgttt tacactcttc tctgggatgg   1320

attctgtaat cattggcaca ggtcctgccc catttataga tcctggccca gcccctgcca   1380

caggtgcctc tccagatttc cccttagatc ctcggatggt catctccatc tccatgaata   1440

caccagcccc ctctctgcta atgcaaaagg caataaagtg tattggctgg              1490


<210>  66
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the CD3E protein sequence of the transformed humanized mouse

<400>  66

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Leu Thr 
        115                 120                 125             


Ala Val Ala Ile Ile Ile Ile Val Asp Ile Cys Ile Thr Leu Gly Leu 
    130                 135                 140                 


Leu Met Val Ile Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Thr Gly Ala Gly Ser Arg Pro Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Ala Val 
        195                 200                 205         


