                         SEQUENCE LISTING

<110>  NORTH CAROLINA STATE UNIVERSITY
 
<120>  SITE-SPECIFIC GENOME MODIFICATION TECHNOLOGY

<130>  NCSU-39212.601

<150>  US 63/149,419
<151>  2021-02-15

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  1

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Lys Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Met Asn Ile His Ser Gly Arg Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Arg Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asn 
        275                 280                 285             


Arg Lys Ser Ile Lys Lys Asn Leu Met Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr Leu Gln Glu Ile Phe Ala 
                325                 330                 335     


Asn Glu Met Ala Lys Leu Asp Asp Ser Phe Phe Gln Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys Asn Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Leu Ala Asp Glu Val Ala Tyr His Arg Asn Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Ala Asp Ser Pro Glu Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu Asn Ser Asp Val Ala Lys 
            420                 425                 430         


Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn Gln Leu Phe Glu Glu Ser 
        435                 440                 445             


Pro Leu Asp Glu Ile Glu Val Asp Ala Lys Gly Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu Ile Ala Val Phe Pro Asn 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile Ile Ala Leu Ala Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Thr Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Glu Leu Leu 
        515                 520                 525             


Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Ser Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Ser Asn Ser Glu 
545                 550                 555                 560 


Val Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Ala Leu Leu Lys Thr Leu Val Arg Gln Gln Phe 
            580                 585                 590         


Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp Asp Thr Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Val Gly Ile Gly Ile Lys His Arg Lys Arg Thr Thr Lys 
    610                 615                 620                 


Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
625                 630                 635                 640 


Lys Met Asp Gly Ala Glu Glu Leu Leu Ala Lys Leu Asn Arg Asp Asp 
                645                 650                 655     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            660                 665                 670         


Ile His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Glu Phe 
        675                 680                 685             


Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    690                 695                 700                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
705                 710                 715                 720 


Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu Ala Ile Thr Pro Trp Asn 
                725                 730                 735     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            740                 745                 750         


Arg Met Thr Asn Phe Asp Glu Gln Leu Pro Asn Lys Lys Val Leu Pro 
        755                 760                 765             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    770                 775                 780                 


Lys Val Lys Tyr Val Thr Glu Arg Met Arg Lys Pro Glu Phe Leu Ser 
785                 790                 795                 800 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                805                 810                 815     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            820                 825                 830         


Cys Phe Asp Ser Val Glu Ile Ile Gly Val Glu Asp Arg Phe Asn Ala 
        835                 840                 845             


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
    850                 855                 860                 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
865                 870                 875                 880 


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
                885                 890                 895     


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
            900                 905                 910         


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Met Ile Asn Gly 
        915                 920                 925             


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
    930                 935                 940                 


Asp Gly Phe Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
945                 950                 955                 960 


Leu Thr Phe Lys Glu Glu Ile Glu Lys Ala Gln Val Ser Gly Gln Gly 
                965                 970                 975     


Asp Ser Leu His Glu Gln Ile Ala Asp Leu Ala Gly Ser Pro Ala Ile 
            980                 985                 990         


Lys Lys Gly Ile Leu Gln Thr Val  Lys Ile Val Asp Glu  Leu Val Lys 
        995                 1000                 1005             


Val Met  Gly His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1010                 1015                 1020             


Glu Asn  Gln Thr Thr Thr Lys  Gly Leu Gln Gln Ser  Arg Glu Arg 
    1025                 1030                 1035             


Lys Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Glu  Ser Gln Ile 
    1040                 1045                 1050             


Leu Lys  Glu Asn Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1070                 1075                 1080             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp Ala 
    1085                 1090                 1095             


Ile Val  Pro Gln Ser Phe Ile  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1100                 1105                 1110             


Val Leu  Thr Arg Ser Val Glu  Asn Arg Gly Lys Ser  Asp Asn Val 
    1115                 1120                 1125             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1130                 1135                 1140             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1145                 1150                 1155             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Ala Asp  Lys Ala Gly 
    1160                 1165                 1170             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1175                 1180                 1185             


Val Ala  Arg Ile Leu Asp Ser  Arg Met Asn Thr Lys  Arg Asp Lys 
    1190                 1195                 1200             


Asn Asp  Lys Pro Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1205                 1210                 1215             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Leu  Tyr Lys Val 
    1220                 1225                 1230             


Arg Asp  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1250                 1255                 1260             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1265                 1270                 1275             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1280                 1285                 1290             


Arg Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Val 
    1295                 1300                 1305             


Lys Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1310                 1315                 1320             


Asn Gly  Glu Thr Gly Glu Val  Val Trp Asn Lys Glu  Lys Asp Phe 
    1325                 1330                 1335             


Ala Thr  Val Arg Lys Val Leu  Ala Met Pro Gln Val  Asn Ile Val 
    1340                 1345                 1350             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1355                 1360                 1365             


Leu Ser  Lys Arg Glu Ser Ala  Lys Leu Ile Pro Arg  Lys Lys Gly 
    1370                 1375                 1380             


Trp Asp  Thr Arg Lys Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala 
    1385                 1390                 1395             


Tyr Ser  Ile Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ala Lys 
    1400                 1405                 1410             


Lys Leu  Lys Ser Val Lys Val  Leu Val Gly Ile Thr  Ile Met Glu 
    1415                 1420                 1425             


Lys Gly  Ser Tyr Glu Lys Asp  Pro Ile Gly Phe Leu  Glu Ala Lys 
    1430                 1435                 1440             


Gly Tyr  Lys Asp Ile Lys Lys  Glu Leu Ile Phe Lys  Leu Pro Lys 
    1445                 1450                 1455             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1460                 1465                 1470             


Ser Ala  Thr Glu Leu Gln Lys  Ala Asn Glu Leu Val  Leu Pro Gln 
    1475                 1480                 1485             


His Leu  Val Arg Leu Leu Tyr  Tyr Thr Gln Asn Ile  Ser Ala Thr 
    1490                 1495                 1500             


Thr Gly  Ser Asn Asn Leu Gly  Tyr Ile Glu Gln His  Arg Glu Glu 
    1505                 1510                 1515             


Phe Lys  Glu Ile Phe Glu Lys  Ile Ile Asp Phe Ser  Glu Lys Tyr 
    1520                 1525                 1530             


Ile Leu  Lys Asn Lys Val Asn  Ser Asn Leu Lys Ser  Ser Phe Asp 
    1535                 1540                 1545             


Glu Gln  Phe Ala Val Ser Asp  Ser Ile Leu Leu Ser  Asn Ser Phe 
    1550                 1555                 1560             


Val Ser  Leu Leu Lys Tyr Thr  Ser Phe Gly Ala Ser  Gly Gly Phe 
    1565                 1570                 1575             


Thr Phe  Leu Asp Leu Asp Val  Lys Gln Gly Arg Leu  Arg Tyr Gln 
    1580                 1585                 1590             


Thr Val  Thr Glu Val Leu Asp  Ala Thr Leu Ile Tyr  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Thr Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp 
    


<210>  2
<211>  1624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Ala Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Met Asn Ile His Ser Gly Arg Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Arg Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asn 
        275                 280                 285             


Arg Lys Ser Ile Lys Lys Asn Leu Met Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr Leu Gln Glu Ile Phe Ala 
                325                 330                 335     


Asn Glu Met Ala Lys Leu Asp Asp Ser Phe Phe Gln Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys Asn Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Leu Ala Asp Glu Val Ala Tyr His Arg Asn Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Ala Asp Ser Pro Glu Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu Asn Ser Asp Val Ala Lys 
            420                 425                 430         


Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn Gln Leu Phe Glu Glu Ser 
        435                 440                 445             


Pro Leu Asp Glu Ile Glu Val Asp Ala Lys Gly Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu Ile Ala Val Phe Pro Asn 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile Ile Ala Leu Ala Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Thr Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Glu Leu Leu 
        515                 520                 525             


Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Ser Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Ser Asn Ser Glu 
545                 550                 555                 560 


Val Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Ala Leu Leu Lys Thr Leu Val Arg Gln Gln Phe 
            580                 585                 590         


Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp Asp Thr Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Val Gly Ile Gly Ile Lys His Arg Lys Arg Thr Thr Lys 
    610                 615                 620                 


Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
625                 630                 635                 640 


Lys Met Asp Gly Ala Glu Glu Leu Leu Ala Lys Leu Asn Arg Asp Asp 
                645                 650                 655     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            660                 665                 670         


Ile His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Glu Phe 
        675                 680                 685             


Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    690                 695                 700                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
705                 710                 715                 720 


Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu Ala Ile Thr Pro Trp Asn 
                725                 730                 735     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            740                 745                 750         


Arg Met Thr Asn Phe Asp Glu Gln Leu Pro Asn Lys Lys Val Leu Pro 
        755                 760                 765             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    770                 775                 780                 


Lys Val Lys Tyr Val Thr Glu Arg Met Arg Lys Pro Glu Phe Leu Ser 
785                 790                 795                 800 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                805                 810                 815     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            820                 825                 830         


Cys Phe Asp Ser Val Glu Ile Ile Gly Val Glu Asp Arg Phe Asn Ala 
        835                 840                 845             


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
    850                 855                 860                 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
865                 870                 875                 880 


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
                885                 890                 895     


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
            900                 905                 910         


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Met Ile Asn Gly 
        915                 920                 925             


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
    930                 935                 940                 


Asp Gly Phe Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
945                 950                 955                 960 


Leu Thr Phe Lys Glu Glu Ile Glu Lys Ala Gln Val Ser Gly Gln Gly 
                965                 970                 975     


Asp Ser Leu His Glu Gln Ile Ala Asp Leu Ala Gly Ser Pro Ala Ile 
            980                 985                 990         


Lys Lys Gly Ile Leu Gln Thr Val  Lys Ile Val Asp Glu  Leu Val Lys 
        995                 1000                 1005             


Val Met  Gly His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1010                 1015                 1020             


Glu Asn  Gln Thr Thr Thr Lys  Gly Leu Gln Gln Ser  Arg Glu Arg 
    1025                 1030                 1035             


Lys Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Glu  Ser Gln Ile 
    1040                 1045                 1050             


Leu Lys  Glu Asn Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1070                 1075                 1080             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp Ala 
    1085                 1090                 1095             


Ile Val  Pro Gln Ser Phe Ile  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1100                 1105                 1110             


Val Leu  Thr Arg Ser Val Glu  Asn Arg Gly Lys Ser  Asp Asn Val 
    1115                 1120                 1125             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1130                 1135                 1140             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1145                 1150                 1155             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Ala Asp  Lys Ala Gly 
    1160                 1165                 1170             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1175                 1180                 1185             


Val Ala  Arg Ile Leu Asp Ser  Arg Met Asn Thr Lys  Arg Asp Lys 
    1190                 1195                 1200             


Asn Asp  Lys Pro Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1205                 1210                 1215             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Leu  Tyr Lys Val 
    1220                 1225                 1230             


Arg Asp  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1250                 1255                 1260             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1265                 1270                 1275             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1280                 1285                 1290             


Arg Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Val 
    1295                 1300                 1305             


Lys Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1310                 1315                 1320             


Asn Gly  Glu Thr Gly Glu Val  Val Trp Asn Lys Glu  Lys Asp Phe 
    1325                 1330                 1335             


Ala Thr  Val Arg Lys Val Leu  Ala Met Pro Gln Val  Asn Ile Val 
    1340                 1345                 1350             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1355                 1360                 1365             


Leu Ser  Lys Arg Glu Ser Ala  Lys Leu Ile Pro Arg  Lys Lys Gly 
    1370                 1375                 1380             


Trp Asp  Thr Arg Lys Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala 
    1385                 1390                 1395             


Tyr Ser  Ile Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ala Lys 
    1400                 1405                 1410             


Lys Leu  Lys Ser Val Lys Val  Leu Val Gly Ile Thr  Ile Met Glu 
    1415                 1420                 1425             


Lys Gly  Ser Tyr Glu Lys Asp  Pro Ile Gly Phe Leu  Glu Ala Lys 
    1430                 1435                 1440             


Gly Tyr  Lys Asp Ile Lys Lys  Glu Leu Ile Phe Lys  Leu Pro Lys 
    1445                 1450                 1455             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1460                 1465                 1470             


Ser Ala  Thr Glu Leu Gln Lys  Ala Asn Glu Leu Val  Leu Pro Gln 
    1475                 1480                 1485             


His Leu  Val Arg Leu Leu Tyr  Tyr Thr Gln Asn Ile  Ser Ala Thr 
    1490                 1495                 1500             


Thr Gly  Ser Asn Asn Leu Gly  Tyr Ile Glu Gln His  Arg Glu Glu 
    1505                 1510                 1515             


Phe Lys  Glu Ile Phe Glu Lys  Ile Ile Asp Phe Ser  Glu Lys Tyr 
    1520                 1525                 1530             


Ile Leu  Lys Asn Lys Val Asn  Ser Asn Leu Lys Ser  Ser Phe Asp 
    1535                 1540                 1545             


Glu Gln  Phe Ala Val Ser Asp  Ser Ile Leu Leu Ser  Asn Ser Phe 
    1550                 1555                 1560             


Val Ser  Leu Leu Lys Tyr Thr  Ser Phe Gly Ala Ser  Gly Gly Phe 
    1565                 1570                 1575             


Thr Phe  Leu Asp Leu Asp Val  Lys Gln Gly Arg Leu  Arg Tyr Gln 
    1580                 1585                 1590             


Thr Val  Thr Glu Val Leu Asp  Ala Thr Leu Ile Tyr  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Thr Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp 
    


<210>  3
<211>  1624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Lys Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Met Asn Ile His Ser Gly Arg Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Arg Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asn 
        275                 280                 285             


Arg Lys Ser Ile Lys Lys Asn Leu Met Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr Leu Gln Glu Ile Phe Ala 
                325                 330                 335     


Asn Glu Met Ala Lys Leu Asp Asp Ser Phe Phe Gln Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys Asn Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Leu Ala Asp Glu Val Ala Tyr His Arg Asn Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Ala Asp Ser Pro Glu Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu Asn Ser Asp Val Ala Lys 
            420                 425                 430         


Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn Gln Leu Phe Glu Glu Ser 
        435                 440                 445             


Pro Leu Asp Glu Ile Glu Val Asp Ala Lys Gly Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu Ile Ala Val Phe Pro Asn 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile Ile Ala Leu Ala Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Thr Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Glu Leu Leu 
        515                 520                 525             


Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Ser Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Ser Asn Ser Glu 
545                 550                 555                 560 


Val Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Ala Leu Leu Lys Thr Leu Val Arg Gln Gln Phe 
            580                 585                 590         


Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp Asp Thr Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Val Gly Ile Gly Ile Lys His Arg Lys Arg Thr Thr Lys 
    610                 615                 620                 


Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
625                 630                 635                 640 


Lys Met Asp Gly Ala Glu Glu Leu Leu Ala Lys Leu Asn Arg Asp Asp 
                645                 650                 655     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            660                 665                 670         


Ile His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Glu Phe 
        675                 680                 685             


Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    690                 695                 700                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
705                 710                 715                 720 


Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu Ala Ile Thr Pro Trp Asn 
                725                 730                 735     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            740                 745                 750         


Arg Met Thr Asn Phe Asp Glu Gln Leu Pro Asn Lys Lys Val Leu Pro 
        755                 760                 765             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    770                 775                 780                 


Lys Val Lys Tyr Val Thr Glu Arg Met Arg Lys Pro Glu Phe Leu Ser 
785                 790                 795                 800 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                805                 810                 815     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            820                 825                 830         


Cys Phe Asp Ser Val Glu Ile Ile Gly Val Glu Asp Arg Phe Asn Ala 
        835                 840                 845             


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
    850                 855                 860                 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
865                 870                 875                 880 


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
                885                 890                 895     


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
            900                 905                 910         


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Met Ile Asn Gly 
        915                 920                 925             


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
    930                 935                 940                 


Asp Gly Phe Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
945                 950                 955                 960 


Leu Thr Phe Lys Glu Glu Ile Glu Lys Ala Gln Val Ser Gly Gln Gly 
                965                 970                 975     


Asp Ser Leu His Glu Gln Ile Ala Asp Leu Ala Gly Ser Pro Ala Ile 
            980                 985                 990         


Lys Lys Gly Ile Leu Gln Thr Val  Lys Ile Val Asp Glu  Leu Val Lys 
        995                 1000                 1005             


Val Met  Gly His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1010                 1015                 1020             


Glu Asn  Gln Thr Thr Thr Lys  Gly Leu Gln Gln Ser  Arg Glu Arg 
    1025                 1030                 1035             


Lys Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Glu  Ser Gln Ile 
    1040                 1045                 1050             


Leu Lys  Glu Asn Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1070                 1075                 1080             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His 
    1085                 1090                 1095             


Ile Val  Pro Gln Ser Phe Ile  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1100                 1105                 1110             


Val Leu  Thr Arg Ser Val Glu  Asn Arg Gly Lys Ser  Asp Asn Val 
    1115                 1120                 1125             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1130                 1135                 1140             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1145                 1150                 1155             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Ala Asp  Lys Ala Gly 
    1160                 1165                 1170             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1175                 1180                 1185             


Val Ala  Arg Ile Leu Asp Ser  Arg Met Asn Thr Lys  Arg Asp Lys 
    1190                 1195                 1200             


Asn Asp  Lys Pro Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1205                 1210                 1215             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Leu  Tyr Lys Val 
    1220                 1225                 1230             


Arg Asp  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1250                 1255                 1260             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1265                 1270                 1275             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1280                 1285                 1290             


Arg Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Val 
    1295                 1300                 1305             


Lys Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1310                 1315                 1320             


Asn Gly  Glu Thr Gly Glu Val  Val Trp Asn Lys Glu  Lys Asp Phe 
    1325                 1330                 1335             


Ala Thr  Val Arg Lys Val Leu  Ala Met Pro Gln Val  Asn Ile Val 
    1340                 1345                 1350             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1355                 1360                 1365             


Leu Ser  Lys Arg Glu Ser Ala  Lys Leu Ile Pro Arg  Lys Lys Gly 
    1370                 1375                 1380             


Trp Asp  Thr Arg Lys Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala 
    1385                 1390                 1395             


Tyr Ser  Ile Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ala Lys 
    1400                 1405                 1410             


Lys Leu  Lys Ser Val Lys Val  Leu Val Gly Ile Thr  Ile Met Glu 
    1415                 1420                 1425             


Lys Gly  Ser Tyr Glu Lys Asp  Pro Ile Gly Phe Leu  Glu Ala Lys 
    1430                 1435                 1440             


Gly Tyr  Lys Asp Ile Lys Lys  Glu Leu Ile Phe Lys  Leu Pro Lys 
    1445                 1450                 1455             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1460                 1465                 1470             


Ser Ala  Thr Glu Leu Gln Lys  Ala Asn Glu Leu Val  Leu Pro Gln 
    1475                 1480                 1485             


His Leu  Val Arg Leu Leu Tyr  Tyr Thr Gln Asn Ile  Ser Ala Thr 
    1490                 1495                 1500             


Thr Gly  Ser Asn Asn Leu Gly  Tyr Ile Glu Gln His  Arg Glu Glu 
    1505                 1510                 1515             


Phe Lys  Glu Ile Phe Glu Lys  Ile Ile Asp Phe Ser  Glu Lys Tyr 
    1520                 1525                 1530             


Ile Leu  Lys Asn Lys Val Asn  Ser Asn Leu Lys Ser  Ser Phe Asp 
    1535                 1540                 1545             


Glu Gln  Phe Ala Val Ser Asp  Ser Ile Leu Leu Ser  Asn Ser Phe 
    1550                 1555                 1560             


Val Ser  Leu Leu Lys Tyr Thr  Ser Phe Gly Ala Ser  Gly Gly Phe 
    1565                 1570                 1575             


Thr Phe  Leu Asp Leu Asp Val  Lys Gln Gly Arg Leu  Arg Tyr Gln 
    1580                 1585                 1590             


Thr Val  Thr Glu Val Leu Asp  Ala Thr Leu Ile Tyr  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Thr Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp 
    


<210>  4
<211>  1624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Ala Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Met Asn Ile His Ser Gly Arg Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Arg Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asn 
        275                 280                 285             


Arg Lys Ser Ile Lys Lys Asn Leu Met Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr Leu Gln Glu Ile Phe Ala 
                325                 330                 335     


Asn Glu Met Ala Lys Leu Asp Asp Ser Phe Phe Gln Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys Asn Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Leu Ala Asp Glu Val Ala Tyr His Arg Asn Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Ala Asp Ser Pro Glu Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu Asn Ser Asp Val Ala Lys 
            420                 425                 430         


Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn Gln Leu Phe Glu Glu Ser 
        435                 440                 445             


Pro Leu Asp Glu Ile Glu Val Asp Ala Lys Gly Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu Ile Ala Val Phe Pro Asn 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile Ile Ala Leu Ala Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Thr Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Glu Leu Leu 
        515                 520                 525             


Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Ser Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Ser Asn Ser Glu 
545                 550                 555                 560 


Val Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Ala Leu Leu Lys Thr Leu Val Arg Gln Gln Phe 
            580                 585                 590         


Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp Asp Thr Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Val Gly Ile Gly Ile Lys His Arg Lys Arg Thr Thr Lys 
    610                 615                 620                 


Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
625                 630                 635                 640 


Lys Met Asp Gly Ala Glu Glu Leu Leu Ala Lys Leu Asn Arg Asp Asp 
                645                 650                 655     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            660                 665                 670         


Ile His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Glu Phe 
        675                 680                 685             


Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    690                 695                 700                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
705                 710                 715                 720 


Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu Ala Ile Thr Pro Trp Asn 
                725                 730                 735     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            740                 745                 750         


Arg Met Thr Asn Phe Asp Glu Gln Leu Pro Asn Lys Lys Val Leu Pro 
        755                 760                 765             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    770                 775                 780                 


Lys Val Lys Tyr Val Thr Glu Arg Met Arg Lys Pro Glu Phe Leu Ser 
785                 790                 795                 800 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                805                 810                 815     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            820                 825                 830         


Cys Phe Asp Ser Val Glu Ile Ile Gly Val Glu Asp Arg Phe Asn Ala 
        835                 840                 845             


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
    850                 855                 860                 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
865                 870                 875                 880 


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
                885                 890                 895     


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
            900                 905                 910         


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Met Ile Asn Gly 
        915                 920                 925             


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
    930                 935                 940                 


Asp Gly Phe Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
945                 950                 955                 960 


Leu Thr Phe Lys Glu Glu Ile Glu Lys Ala Gln Val Ser Gly Gln Gly 
                965                 970                 975     


Asp Ser Leu His Glu Gln Ile Ala Asp Leu Ala Gly Ser Pro Ala Ile 
            980                 985                 990         


Lys Lys Gly Ile Leu Gln Thr Val  Lys Ile Val Asp Glu  Leu Val Lys 
        995                 1000                 1005             


Val Met  Gly His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1010                 1015                 1020             


Glu Asn  Gln Thr Thr Thr Lys  Gly Leu Gln Gln Ser  Arg Glu Arg 
    1025                 1030                 1035             


Lys Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Glu  Ser Gln Ile 
    1040                 1045                 1050             


Leu Lys  Glu Asn Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1070                 1075                 1080             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His 
    1085                 1090                 1095             


Ile Val  Pro Gln Ser Phe Ile  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1100                 1105                 1110             


Val Leu  Thr Arg Ser Val Glu  Asn Arg Gly Lys Ser  Asp Asn Val 
    1115                 1120                 1125             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1130                 1135                 1140             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1145                 1150                 1155             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Ala Asp  Lys Ala Gly 
    1160                 1165                 1170             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1175                 1180                 1185             


Val Ala  Arg Ile Leu Asp Ser  Arg Met Asn Thr Lys  Arg Asp Lys 
    1190                 1195                 1200             


Asn Asp  Lys Pro Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1205                 1210                 1215             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Leu  Tyr Lys Val 
    1220                 1225                 1230             


Arg Asp  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1250                 1255                 1260             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1265                 1270                 1275             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1280                 1285                 1290             


Arg Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Val 
    1295                 1300                 1305             


Lys Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1310                 1315                 1320             


Asn Gly  Glu Thr Gly Glu Val  Val Trp Asn Lys Glu  Lys Asp Phe 
    1325                 1330                 1335             


Ala Thr  Val Arg Lys Val Leu  Ala Met Pro Gln Val  Asn Ile Val 
    1340                 1345                 1350             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1355                 1360                 1365             


Leu Ser  Lys Arg Glu Ser Ala  Lys Leu Ile Pro Arg  Lys Lys Gly 
    1370                 1375                 1380             


Trp Asp  Thr Arg Lys Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala 
    1385                 1390                 1395             


Tyr Ser  Ile Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ala Lys 
    1400                 1405                 1410             


Lys Leu  Lys Ser Val Lys Val  Leu Val Gly Ile Thr  Ile Met Glu 
    1415                 1420                 1425             


Lys Gly  Ser Tyr Glu Lys Asp  Pro Ile Gly Phe Leu  Glu Ala Lys 
    1430                 1435                 1440             


Gly Tyr  Lys Asp Ile Lys Lys  Glu Leu Ile Phe Lys  Leu Pro Lys 
    1445                 1450                 1455             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1460                 1465                 1470             


Ser Ala  Thr Glu Leu Gln Lys  Ala Asn Glu Leu Val  Leu Pro Gln 
    1475                 1480                 1485             


His Leu  Val Arg Leu Leu Tyr  Tyr Thr Gln Asn Ile  Ser Ala Thr 
    1490                 1495                 1500             


Thr Gly  Ser Asn Asn Leu Gly  Tyr Ile Glu Gln His  Arg Glu Glu 
    1505                 1510                 1515             


Phe Lys  Glu Ile Phe Glu Lys  Ile Ile Asp Phe Ser  Glu Lys Tyr 
    1520                 1525                 1530             


Ile Leu  Lys Asn Lys Val Asn  Ser Asn Leu Lys Ser  Ser Phe Asp 
    1535                 1540                 1545             


Glu Gln  Phe Ala Val Ser Asp  Ser Ile Leu Leu Ser  Asn Ser Phe 
    1550                 1555                 1560             


Val Ser  Leu Leu Lys Tyr Thr  Ser Phe Gly Ala Ser  Gly Gly Phe 
    1565                 1570                 1575             


Thr Phe  Leu Asp Leu Asp Val  Lys Gln Gly Arg Leu  Arg Tyr Gln 
    1580                 1585                 1590             


Thr Val  Thr Glu Val Leu Asp  Ala Thr Leu Ile Tyr  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Thr Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp 
    


<210>  5
<211>  355
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5

Met Ile Thr Tyr Thr Gln Gly Asn Leu Leu Asp Ala Pro Val Glu Ala 
1               5                   10                  15      


Leu Val Asn Thr Val Asn Thr Val Gly Val Met Gly Lys Gly Ile Ala 
            20                  25                  30          


Leu Met Phe Lys Glu Arg Phe Pro Glu Asn Met Lys Val Tyr Ala Leu 
        35                  40                  45              


Ala Cys Lys Gln Lys Gln Val Ile Thr Gly Lys Met Phe Ile Thr Glu 
    50                  55                  60                  


Thr Gly Glu Leu Met Gly Pro Arg Trp Ile Val Asn Phe Pro Thr Lys 
65                  70                  75                  80  


Gln His Trp Arg Ala Asp Ser Arg Met Glu Trp Ile Glu Asp Gly Leu 
                85                  90                  95      


Gln Asp Leu Arg Arg Phe Leu Ile Glu Glu Asn Val Gln Ser Ile Ala 
            100                 105                 110         


Ile Pro Pro Leu Gly Ala Gly Asn Gly Gly Leu Asn Trp Pro Asp Val 
        115                 120                 125             


Arg Ala Gln Ile Glu Ser Ala Leu Gly Asp Leu Gln Asp Val Asp Ile 
    130                 135                 140                 


Leu Ile Tyr Gln Pro Thr Glu Lys Tyr Gln Asn Val Ala Lys Ser Thr 
145                 150                 155                 160 


Gly Val Lys Lys Leu Thr Pro Ala Arg Ala Ala Ile Ala Glu Leu Val 
                165                 170                 175     


Arg Arg Tyr Trp Val Leu Gly Met Glu Cys Ser Leu Leu Glu Ile Gln 
            180                 185                 190         


Lys Leu Ala Trp Leu Leu Gln Arg Ala Ile Glu Gln His Gln Gln Asp 
        195                 200                 205             


Asp Ile Leu Lys Leu Arg Phe Glu Ala His Tyr Tyr Gly Pro Tyr Ala 
    210                 215                 220                 


Pro Asn Leu Asn His Leu Leu Asn Ala Leu Asp Gly Thr Tyr Leu Lys 
225                 230                 235                 240 


Ala Glu Lys Arg Ile Pro Asp Ser Gln Pro Leu Asp Val Ile Trp Phe 
                245                 250                 255     


Asn Asp Gln Lys Lys Glu His Val Asn Ala Tyr Leu Asn Asn Glu Ala 
            260                 265                 270         


Arg Glu Trp Leu Pro Ala Leu Glu Gln Val Ser Gln Leu Ile Asp Gly 
        275                 280                 285             


Phe Glu Ser Pro Phe Gly Leu Glu Leu Leu Ala Thr Val Asp Trp Leu 
    290                 295                 300                 


Leu Ser Arg Gly Glu Cys Gln Pro Thr Leu Asp Ser Val Lys Glu Gly 
305                 310                 315                 320 


Leu His Gln Trp Pro Ala Gly Glu Arg Trp Ala Ser Arg Lys Leu Arg 
                325                 330                 335     


Leu Phe Asp Asn Asn Asn Leu Gln Phe Ala Ile Asn Arg Val Met Glu 
            340                 345                 350         


Phe His Cys 
        355 


<210>  6
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6

Met Asp Val Arg Ala Gln Ile Glu Ser Ala Leu Gly Asp Leu Gln Asp 
1               5                   10                  15      


Val Asp Ile Leu Ile Tyr Gln Pro Thr Glu Lys Tyr Gln Asn Val Ala 
            20                  25                  30          


Lys Ser Thr Gly Val Lys Lys Leu Thr Pro Ala Arg Ala Ala Ile Ala 
        35                  40                  45              


Glu Leu Val Arg Arg Tyr Trp Val Leu Gly Met Glu Cys Ser Leu Leu 
    50                  55                  60                  


Glu Ile Gln Lys Leu Ala Trp Leu Leu Gln Arg Ala Ile Glu Gln His 
65                  70                  75                  80  


Gln Gln Asp Asp Ile Leu Lys Leu Arg Phe Glu Ala His Tyr Tyr Gly 
                85                  90                  95      


Pro Tyr Ala Pro Asn Leu Asn His Leu Leu Asn Ala Leu Asp Gly Thr 
            100                 105                 110         


Tyr Leu Lys Ala Glu Lys Arg Ile Pro Asp Ser Gln Pro Leu Asp Val 
        115                 120                 125             


Ile Trp Phe Asn Asp Gln Lys Lys Glu His Val Asn Ala Tyr Leu Asn 
    130                 135                 140                 


Asn Glu Ala Arg Glu Trp Leu Pro Ala Leu Glu Gln Val Ser Gln Leu 
145                 150                 155                 160 


Ile Asp Gly Phe Glu Ser Pro Phe Gly Leu Glu Leu Leu Ala Thr Val 
                165                 170                 175     


Asp Trp Leu Leu Ser Arg Gly Glu Cys Gln Pro Thr Leu Asp Ser Val 
            180                 185                 190         


Lys Glu Gly Leu His Gln Trp Pro Ala Gly Glu Arg Trp Ala Ser Arg 
        195                 200                 205             


Lys Leu Arg Leu Phe Asp Asn Asn Asn Leu Gln Phe Ala Ile Asn Arg 
    210                 215                 220                 


Val Met Glu Phe His Cys 
225                 230 


<210>  7
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7

Met Ile Thr Tyr Thr Gln Gly Asn Leu Leu Asp Ala Pro Val Glu Ala 
1               5                   10                  15      


Leu Val Asn Thr Val Asn Thr Val Gly Val Met Gly Lys Gly Ile Ala 
            20                  25                  30          


Leu Met Phe Lys Glu Arg Phe Pro Glu Asn Met Lys Val Tyr Ala Leu 
        35                  40                  45              


Ala Cys Lys Gln Lys Gln Val Ile Thr Gly Lys Met Phe Ile Thr Glu 
    50                  55                  60                  


Thr Gly Glu Leu Met Gly Pro Arg Trp Ile Val Asn Phe Pro Thr Lys 
65                  70                  75                  80  


Gln His Trp Arg Ala Asp Ser Arg Met Glu Trp Ile Glu Asp Gly Leu 
                85                  90                  95      


Gln Asp Leu Arg Arg Phe Leu Ile Glu Glu Asn Val Gln Ser Ile Ala 
            100                 105                 110         


Ile Pro Pro Leu Gly Ala Gly Asn Gly Gly Leu Asn Trp Pro 
        115                 120                 125     


<210>  8
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8

Met Pro Ala Ser Ile Pro Arg Arg Asn Ile Val Gly Lys Glu Lys Lys 
1               5                   10                  15      


Ser Arg Ile Leu Thr Lys Pro Cys Val Ile Glu Tyr Glu Gly Gln Ile 
            20                  25                  30          


Val Gly Tyr Gly Ser Lys Glu Leu Arg Val Glu Thr Ile Ser Cys Trp 
        35                  40                  45              


Leu Ala Arg Thr Ile Ile Gln Thr Lys His Tyr Ser Arg Arg Phe Val 
    50                  55                  60                  


Asn Asn Ser Tyr Leu His Leu Gly Val Phe Ser Gly Arg Asp Leu Val 
65                  70                  75                  80  


Gly Val Leu Gln Trp Gly Tyr Ala Leu Asn Pro Asn Ser Gly Arg Arg 
                85                  90                  95      


Val Val Leu Glu Thr Asp Asn Arg Gly Tyr Met Glu Leu Asn Arg Met 
            100                 105                 110         


Trp Leu His Asp Asp Met Pro Arg Asn Ser Glu Ser Arg Ala Ile Ser 
        115                 120                 125             


Tyr Ala Leu Lys Val Ile Arg Leu Leu Tyr Pro Ser Val Glu Trp Val 
    130                 135                 140                 


Gln Ser Phe Ala Asp Glu Arg Cys Gly Arg Ala Gly Val Val Tyr Gln 
145                 150                 155                 160 


Ala Ser Asn Phe Asp Phe Ile Gly Ser His Glu Ser Thr Phe Tyr Glu 
                165                 170                 175     


Leu Asp Gly Glu Trp Tyr His Glu Ile Thr Met Asn Ala Ile Lys Arg 
            180                 185                 190         


Gly Gly Gln Arg Gly Val Tyr Leu Arg Ala Asn Lys Glu Arg Ala Val 
        195                 200                 205             


Val His Lys Phe Asn Gln Tyr Arg Tyr Ile Arg Phe Leu Asn Lys Arg 
    210                 215                 220                 


Ala Arg Lys Arg Leu Asn Thr Lys Leu Phe Lys Val Gln Pro Tyr Pro 
225                 230                 235                 240 


Lys 
    


<210>  9
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9

Met Pro Ala Ser Ile Pro Arg Arg Asn Ile Val Gly Lys Glu Lys Lys 
1               5                   10                  15      


Ser Arg Ile Leu Thr Lys Pro Cys Val Ile Glu Tyr Glu Gly Gln Ile 
            20                  25                  30          


Val Gly Tyr Gly Ser Lys Glu Leu Arg Val Glu Thr Ile Ser Cys Trp 
        35                  40                  45              


Leu Ala Arg Thr Ile Ile Gln Thr Lys His Tyr Ser Arg Arg Phe Val 
    50                  55                  60                  


Asn Asn Ser Tyr Leu His Leu Gly Val Phe Ser Gly Arg Asp Leu Val 
65                  70                  75                  80  


Gly Val Leu Gln Trp Gly Tyr Ala Leu Asn Pro Asn Ser Gly Arg Arg 
                85                  90                  95      


Val Val Leu Glu Thr Asp Asn Arg Gly Tyr Met Glu Leu Asn Arg Met 
            100                 105                 110         


Trp Leu His Asp Asp Met Pro Arg Asn Ser Glu Ser Arg Ala Ile Ser 
        115                 120                 125             


Tyr Ala Leu Lys Val Ile Arg Leu Leu Tyr Pro Ser Val Glu Trp Val 
    130                 135                 140                 


Gln Ser Phe Ala Ala Glu Arg Cys Gly Arg Ala Gly Val Val Tyr Gln 
145                 150                 155                 160 


Ala Ser Asn Phe Asp Phe Ile Gly Ser His Glu Ser Thr Phe Tyr Glu 
                165                 170                 175     


Leu Asp Gly Glu Trp Tyr His Glu Ile Thr Met Asn Ala Ile Lys Arg 
            180                 185                 190         


Gly Gly Gln Arg Gly Val Tyr Leu Arg Ala Asn Lys Glu Arg Ala Val 
        195                 200                 205             


Val His Lys Phe Asn Gln Tyr Arg Tyr Ile Arg Phe Leu Asn Lys Arg 
    210                 215                 220                 


Ala Arg Lys Arg Leu Asn Thr Lys Leu Phe Lys Val Gln Pro Tyr Pro 
225                 230                 235                 240 


Lys 
    


<210>  10
<211>  1647
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10

Met Pro Ala Ser Ile Pro Arg Arg Asn Ile Val Gly Lys Glu Lys Lys 
1               5                   10                  15      


Ser Arg Ile Leu Thr Lys Pro Cys Val Ile Glu Tyr Glu Gly Gln Ile 
            20                  25                  30          


Val Gly Tyr Gly Ser Lys Glu Leu Arg Val Glu Thr Ile Ser Cys Trp 
        35                  40                  45              


Leu Ala Arg Thr Ile Ile Gln Thr Lys His Tyr Ser Arg Arg Phe Val 
    50                  55                  60                  


Asn Asn Ser Tyr Leu His Leu Gly Val Phe Ser Gly Arg Asp Leu Val 
65                  70                  75                  80  


Gly Val Leu Gln Trp Gly Tyr Ala Leu Asn Pro Asn Ser Gly Arg Arg 
                85                  90                  95      


Val Val Leu Glu Thr Asp Asn Arg Gly Tyr Met Glu Leu Asn Arg Met 
            100                 105                 110         


Trp Leu His Asp Asp Met Pro Arg Asn Ser Glu Ser Arg Ala Ile Ser 
        115                 120                 125             


Tyr Ala Leu Lys Val Ile Arg Leu Leu Tyr Pro Ser Val Glu Trp Val 
    130                 135                 140                 


Gln Ser Phe Ala Ala Glu Arg Cys Gly Arg Ala Gly Val Val Tyr Gln 
145                 150                 155                 160 


Ala Ser Asn Phe Asp Phe Ile Gly Ser His Glu Ser Thr Phe Tyr Glu 
                165                 170                 175     


Leu Asp Gly Glu Trp Tyr His Glu Ile Thr Met Asn Ala Ile Lys Arg 
            180                 185                 190         


Gly Gly Gln Arg Gly Val Tyr Leu Arg Ala Asn Lys Glu Arg Ala Val 
        195                 200                 205             


Val His Lys Phe Asn Gln Tyr Arg Tyr Ile Arg Phe Leu Asn Lys Arg 
    210                 215                 220                 


Ala Arg Lys Arg Leu Asn Thr Lys Leu Phe Lys Val Gln Pro Tyr Pro 
225                 230                 235                 240 


Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
                245                 250                 255     


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
            260                 265                 270         


Ser Glu Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
        275                 280                 285             


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
    290                 295                 300                 


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
305                 310                 315                 320 


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
                325                 330                 335     


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
            340                 345                 350         


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
        355                 360                 365             


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
    370                 375                 380                 


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
385                 390                 395                 400 


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
                405                 410                 415     


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
            420                 425                 430         


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
        435                 440                 445             


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
    450                 455                 460                 


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
465                 470                 475                 480 


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
                485                 490                 495     


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
            500                 505                 510         


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
        515                 520                 525             


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
    530                 535                 540                 


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
545                 550                 555                 560 


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
                565                 570                 575     


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
            580                 585                 590         


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
        595                 600                 605             


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
    610                 615                 620                 


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
625                 630                 635                 640 


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
                645                 650                 655     


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
            660                 665                 670         


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
        675                 680                 685             


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
    690                 695                 700                 


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
705                 710                 715                 720 


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
                725                 730                 735     


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
            740                 745                 750         


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
        755                 760                 765             


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
    770                 775                 780                 


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
785                 790                 795                 800 


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
                805                 810                 815     


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
            820                 825                 830         


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
        835                 840                 845             


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
    850                 855                 860                 


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
865                 870                 875                 880 


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
                885                 890                 895     


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
            900                 905                 910         


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
        915                 920                 925             


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
    930                 935                 940                 


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
945                 950                 955                 960 


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
                965                 970                 975     


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
            980                 985                 990         


Ala Gln Val Ser Gly Gln Gly Asp  Ser Leu His Glu Gln  Ile Ala Asp 
        995                 1000                 1005             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1010                 1015                 1020             


Lys Ile  Val Asp Glu Leu Val  Lys Val Met Gly His  Lys Pro Glu 
    1025                 1030                 1035             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Thr Lys 
    1040                 1045                 1050             


Gly Leu  Gln Gln Ser Arg Glu  Arg Lys Lys Arg Ile  Glu Glu Gly 
    1055                 1060                 1065             


Ile Lys  Glu Leu Glu Ser Gln  Ile Leu Lys Glu Asn  Pro Val Glu 
    1070                 1075                 1080             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1085                 1090                 1095             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1100                 1105                 1110             


Leu Ser  Asp Tyr Asp Val Asp  Ala Ile Val Pro Gln  Ser Phe Ile 
    1115                 1120                 1125             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Val Glu 
    1130                 1135                 1140             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1145                 1150                 1155             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1160                 1165                 1170             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1175                 1180                 1185             


Leu Ser  Glu Ala Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1190                 1195                 1200             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Arg Ile  Leu Asp Ser 
    1205                 1210                 1215             


Arg Met  Asn Thr Lys Arg Asp  Lys Asn Asp Lys Pro  Ile Arg Glu 
    1220                 1225                 1230             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1235                 1240                 1245             


Lys Asp  Phe Gln Leu Tyr Lys  Val Arg Asp Ile Asn  Asn Tyr His 
    1250                 1255                 1260             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1265                 1270                 1275             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1280                 1285                 1290             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1295                 1300                 1305             


Glu Ile  Gly Lys Ala Thr Ala  Lys Arg Phe Phe Tyr  Ser Asn Ile 
    1310                 1315                 1320             


Met Asn  Phe Phe Lys Thr Glu  Val Lys Leu Ala Asn  Gly Glu Ile 
    1325                 1330                 1335             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Val 
    1340                 1345                 1350             


Val Trp  Asn Lys Glu Lys Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1355                 1360                 1365             


Ala Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1370                 1375                 1380             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Ser Lys Arg  Glu Ser Ala 
    1385                 1390                 1395             


Lys Leu  Ile Pro Arg Lys Lys  Gly Trp Asp Thr Arg  Lys Tyr Gly 
    1400                 1405                 1410             


Gly Phe  Gly Ser Pro Thr Val  Ala Tyr Ser Ile Leu  Val Val Ala 
    1415                 1420                 1425             


Lys Val  Glu Lys Gly Lys Ala  Lys Lys Leu Lys Ser  Val Lys Val 
    1430                 1435                 1440             


Leu Val  Gly Ile Thr Ile Met  Glu Lys Gly Ser Tyr  Glu Lys Asp 
    1445                 1450                 1455             


Pro Ile  Gly Phe Leu Glu Ala  Lys Gly Tyr Lys Asp  Ile Lys Lys 
    1460                 1465                 1470             


Glu Leu  Ile Phe Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1475                 1480                 1485             


Asn Gly  Arg Arg Arg Met Leu  Ala Ser Ala Thr Glu  Leu Gln Lys 
    1490                 1495                 1500             


Ala Asn  Glu Leu Val Leu Pro  Gln His Leu Val Arg  Leu Leu Tyr 
    1505                 1510                 1515             


Tyr Thr  Gln Asn Ile Ser Ala  Thr Thr Gly Ser Asn  Asn Leu Gly 
    1520                 1525                 1530             


Tyr Ile  Glu Gln His Arg Glu  Glu Phe Lys Glu Ile  Phe Glu Lys 
    1535                 1540                 1545             


Ile Ile  Asp Phe Ser Glu Lys  Tyr Ile Leu Lys Asn  Lys Val Asn 
    1550                 1555                 1560             


Ser Asn  Leu Lys Ser Ser Phe  Asp Glu Gln Phe Ala  Val Ser Asp 
    1565                 1570                 1575             


Ser Ile  Leu Leu Ser Asn Ser  Phe Val Ser Leu Leu  Lys Tyr Thr 
    1580                 1585                 1590             


Ser Phe  Gly Ala Ser Gly Gly  Phe Thr Phe Leu Asp  Leu Asp Val 
    1595                 1600                 1605             


Lys Gln  Gly Arg Leu Arg Tyr  Gln Thr Val Thr Glu  Val Leu Asp 
    1610                 1615                 1620             


Ala Thr  Leu Ile Tyr Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1625                 1630                 1635             


Thr Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1640                 1645         


<210>  11
<211>  200
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11

Met Arg Arg Arg Ala Ala Ala Val Val Leu Ser Leu Ser Ala Val Leu 
1               5                   10                  15      


Ala Thr Ser Ala Ala Thr Ala Pro Ala Gln Thr Pro Thr Ala Thr Ala 
            20                  25                  30          


Thr Ser Ala Lys Ala Ala Ala Pro Ala Cys Pro Arg Phe Asp Asp Pro 
        35                  40                  45              


Val His Ala Ala Ala Asp Pro Arg Val Asp Val Glu Arg Ile Thr Pro 
    50                  55                  60                  


Asp Pro Val Trp Arg Thr Thr Cys Gly Thr Leu Tyr Arg Ser Asp Ser 
65                  70                  75                  80  


Arg Gly Pro Ala Val Val Phe Glu Gln Gly Phe Leu Pro Lys Asp Val 
                85                  90                  95      


Ile Asp Gly Gln Tyr Asp Ile Glu Ser Tyr Val Leu Val Asn Gln Pro 
            100                 105                 110         


Ser Pro Tyr Val Ser Thr Thr Tyr Asp His Asp Leu Tyr Lys Thr Trp 
        115                 120                 125             


Tyr Lys Ser Gly Tyr Asn Tyr Tyr Ile Asp Ala Pro Gly Gly Val Asp 
    130                 135                 140                 


Val Asn Lys Thr Ile Gly Asp Arg His Lys Trp Ala Asp Gln Val Glu 
145                 150                 155                 160 


Val Ala Phe Pro Gly Gly Ile Arg Thr Glu Phe Val Ile Gly Val Cys 
                165                 170                 175     


Pro Val Asp Lys Lys Thr Arg Thr Glu Lys Met Ser Glu Cys Val Gly 
            180                 185                 190         


Asn Pro His Tyr Glu Pro Trp His 
        195                 200 


<210>  12
<211>  200
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12

Met Arg Arg Arg Ala Ala Ala Val Val Leu Ser Leu Ser Ala Val Leu 
1               5                   10                  15      


Ala Thr Ser Ala Ala Thr Ala Pro Ala Gln Thr Pro Thr Ala Thr Ala 
            20                  25                  30          


Thr Ser Ala Lys Ala Ala Ala Pro Ala Cys Pro Arg Phe Asp Asp Pro 
        35                  40                  45              


Val His Ala Ala Ala Asp Pro Arg Val Asp Val Glu Arg Ile Thr Pro 
    50                  55                  60                  


Asp Pro Val Trp Arg Thr Thr Cys Gly Thr Leu Tyr Arg Ser Asp Ser 
65                  70                  75                  80  


Arg Gly Pro Ala Val Val Phe Glu Gln Gly Phe Leu Pro Lys Asp Val 
                85                  90                  95      


Ile Asp Gly Gln Tyr Asp Ile Glu Ser Tyr Val Leu Val Asn Gln Pro 
            100                 105                 110         


Ser Pro Tyr Val Ser Thr Thr Tyr Asp His Asp Leu Tyr Lys Thr Trp 
        115                 120                 125             


Tyr Ala Ser Gly Tyr Asn Tyr Tyr Ile Asp Ala Pro Gly Gly Val Asp 
    130                 135                 140                 


Val Asn Lys Thr Ile Gly Asp Arg His Lys Trp Ala Asp Gln Val Glu 
145                 150                 155                 160 


Val Ala Phe Pro Gly Gly Ile Arg Thr Glu Phe Val Ile Gly Val Cys 
                165                 170                 175     


Pro Val Asp Lys Lys Thr Arg Thr Glu Lys Met Ser Glu Cys Val Gly 
            180                 185                 190         


Asn Pro His Tyr Glu Pro Trp His 
        195                 200 


<210>  13
<211>  1806
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13

Met Arg Arg Arg Ala Ala Ala Val Val Leu Ser Leu Ser Ala Val Leu 
1               5                   10                  15      


Ala Thr Ser Ala Ala Thr Ala Pro Ala Gln Thr Pro Thr Ala Thr Ala 
            20                  25                  30          


Thr Ser Ala Lys Ala Ala Ala Pro Ala Cys Pro Arg Phe Asp Asp Pro 
        35                  40                  45              


Val His Ala Ala Ala Asp Pro Arg Val Asp Val Glu Arg Ile Thr Pro 
    50                  55                  60                  


Asp Pro Val Trp Arg Thr Thr Cys Gly Thr Leu Tyr Arg Ser Asp Ser 
65                  70                  75                  80  


Arg Gly Pro Ala Val Val Phe Glu Gln Gly Phe Leu Pro Lys Asp Val 
                85                  90                  95      


Ile Asp Gly Gln Tyr Asp Ile Glu Ser Tyr Val Leu Val Asn Gln Pro 
            100                 105                 110         


Ser Pro Tyr Val Ser Thr Thr Tyr Asp His Asp Leu Tyr Lys Thr Trp 
        115                 120                 125             


Tyr Ala Ser Gly Tyr Asn Tyr Tyr Ile Asp Ala Pro Gly Gly Val Asp 
    130                 135                 140                 


Val Asn Lys Thr Ile Gly Asp Arg His Lys Trp Ala Asp Gln Val Glu 
145                 150                 155                 160 


Val Ala Phe Pro Gly Gly Ile Arg Thr Glu Phe Val Ile Gly Val Cys 
                165                 170                 175     


Pro Val Asp Lys Lys Thr Arg Thr Glu Lys Met Ser Glu Cys Val Gly 
            180                 185                 190         


Asn Pro His Tyr Glu Pro Trp His Met Arg Arg Arg Ala Ala Ala Val 
        195                 200                 205             


Val Leu Ser Leu Ser Ala Val Leu Ala Thr Ser Ala Ala Thr Ala Pro 
    210                 215                 220                 


Ala Gln Thr Pro Thr Ala Thr Ala Thr Ser Ala Lys Ala Ala Ala Pro 
225                 230                 235                 240 


Ala Cys Pro Arg Phe Asp Asp Pro Val His Ala Ala Ala Asp Pro Arg 
                245                 250                 255     


Val Asp Val Glu Arg Ile Thr Pro Asp Pro Val Trp Arg Thr Thr Cys 
            260                 265                 270         


Gly Thr Leu Tyr Arg Ser Asp Ser Arg Gly Pro Ala Val Val Phe Glu 
        275                 280                 285             


Gln Gly Phe Leu Pro Lys Asp Val Ile Asp Gly Gln Tyr Asp Ile Glu 
    290                 295                 300                 


Ser Tyr Val Leu Val Asn Gln Pro Ser Pro Tyr Val Ser Thr Thr Tyr 
305                 310                 315                 320 


Asp His Asp Leu Tyr Lys Thr Trp Tyr Ala Ser Gly Tyr Asn Tyr Tyr 
                325                 330                 335     


Ile Asp Ala Pro Gly Gly Val Asp Val Asn Lys Thr Ile Gly Asp Arg 
            340                 345                 350         


His Lys Trp Ala Asp Gln Val Glu Val Ala Phe Pro Gly Gly Ile Arg 
        355                 360                 365             


Thr Glu Phe Val Ile Gly Val Cys Pro Val Asp Lys Lys Thr Arg Thr 
    370                 375                 380                 


Glu Lys Met Ser Glu Cys Val Gly Asn Pro His Tyr Glu Pro Trp His 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
                405                 410                 415     


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            420                 425                 430         


Glu Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
        435                 440                 445             


Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys 
    450                 455                 460                 


Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met Gly 
465                 470                 475                 480 


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
                485                 490                 495     


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr 
            500                 505                 510         


Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser Phe 
        515                 520                 525             


Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys Asn 
    530                 535                 540                 


Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr His 
545                 550                 555                 560 


Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp Ser 
                565                 570                 575     


Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Ile 
            580                 585                 590         


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu 
        595                 600                 605             


Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn 
    610                 615                 620                 


Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala Lys 
625                 630                 635                 640 


Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu 
                645                 650                 655     


Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile 
            660                 665                 670         


Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
        675                 680                 685             


Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
    690                 695                 700                 


Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
705                 710                 715                 720 


Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
                725                 730                 735     


Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser Met 
            740                 745                 750         


Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys Thr 
        755                 760                 765             


Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp 
    770                 775                 780                 


Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys His 
785                 790                 795                 800 


Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe 
                805                 810                 815     


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu Ala 
            820                 825                 830         


Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
        835                 840                 845             


Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile Leu 
    850                 855                 860                 


Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys 
865                 870                 875                 880 


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                885                 890                 895     


Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu 
            900                 905                 910         


Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
        915                 920                 925             


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu Pro 
    930                 935                 940                 


Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
945                 950                 955                 960 


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met Arg 
                965                 970                 975     


Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
            980                 985                 990         


Leu Phe Lys Thr Asn Arg Lys Val  Thr Val Lys Gln Leu  Lys Glu Asp 
        995                 1000                 1005             


Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser Val Glu  Ile Ile Gly 
    1010                 1015                 1020             


Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly Thr Tyr  His Asp Leu 
    1025                 1030                 1035             


Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
    1040                 1045                 1050             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1055                 1060                 1065             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1070                 1075                 1080             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  His Tyr Thr 
    1085                 1090                 1095             


Gly Trp  Gly Arg Leu Ser Arg  Lys Met Ile Asn Gly  Ile Arg Asp 
    1100                 1105                 1110             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1115                 1120                 1125             


Phe Ser  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1130                 1135                 1140             


Thr Phe  Lys Glu Glu Ile Glu  Lys Ala Gln Val Ser  Gly Gln Gly 
    1145                 1150                 1155             


Asp Ser  Leu His Glu Gln Ile  Ala Asp Leu Ala Gly  Ser Pro Ala 
    1160                 1165                 1170             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Ile Val  Asp Glu Leu 
    1175                 1180                 1185             


Val Lys  Val Met Gly His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1190                 1195                 1200             


Ala Arg  Glu Asn Gln Thr Thr  Thr Lys Gly Leu Gln  Gln Ser Arg 
    1205                 1210                 1215             


Glu Arg  Lys Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Glu Ser 
    1220                 1225                 1230             


Gln Ile  Leu Lys Glu Asn Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1235                 1240                 1245             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1250                 1255                 1260             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1265                 1270                 1275             


Asp Ala  Ile Val Pro Gln Ser  Phe Ile Lys Asp Asp  Ser Ile Asp 
    1280                 1285                 1290             


Asn Lys  Val Leu Thr Arg Ser  Val Glu Asn Arg Gly  Lys Ser Asp 
    1295                 1300                 1305             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1310                 1315                 1320             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1325                 1330                 1335             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Ala Asp Lys 
    1340                 1345                 1350             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1355                 1360                 1365             


Lys His  Val Ala Arg Ile Leu  Asp Ser Arg Met Asn  Thr Lys Arg 
    1370                 1375                 1380             


Asp Lys  Asn Asp Lys Pro Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1385                 1390                 1395             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Leu Tyr 
    1400                 1405                 1410             


Lys Val  Arg Asp Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1415                 1420                 1425             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1430                 1435                 1440             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1445                 1450                 1455             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1460                 1465                 1470             


Ala Lys  Arg Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1475                 1480                 1485             


Glu Val  Lys Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1490                 1495                 1500             


Glu Thr  Asn Gly Glu Thr Gly  Glu Val Val Trp Asn  Lys Glu Lys 
    1505                 1510                 1515             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ala Met Pro  Gln Val Asn 
    1520                 1525                 1530             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1535                 1540                 1545             


Ser Ile  Leu Ser Lys Arg Glu  Ser Ala Lys Leu Ile  Pro Arg Lys 
    1550                 1555                 1560             


Lys Gly  Trp Asp Thr Arg Lys  Tyr Gly Gly Phe Gly  Ser Pro Thr 
    1565                 1570                 1575             


Val Ala  Tyr Ser Ile Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1580                 1585                 1590             


Ala Lys  Lys Leu Lys Ser Val  Lys Val Leu Val Gly  Ile Thr Ile 
    1595                 1600                 1605             


Met Glu  Lys Gly Ser Tyr Glu  Lys Asp Pro Ile Gly  Phe Leu Glu 
    1610                 1615                 1620             


Ala Lys  Gly Tyr Lys Asp Ile  Lys Lys Glu Leu Ile  Phe Lys Leu 
    1625                 1630                 1635             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Arg Arg Met 
    1640                 1645                 1650             


Leu Ala  Ser Ala Thr Glu Leu  Gln Lys Ala Asn Glu  Leu Val Leu 
    1655                 1660                 1665             


Pro Gln  His Leu Val Arg Leu  Leu Tyr Tyr Thr Gln  Asn Ile Ser 
    1670                 1675                 1680             


Ala Thr  Thr Gly Ser Asn Asn  Leu Gly Tyr Ile Glu  Gln His Arg 
    1685                 1690                 1695             


Glu Glu  Phe Lys Glu Ile Phe  Glu Lys Ile Ile Asp  Phe Ser Glu 
    1700                 1705                 1710             


Lys Tyr  Ile Leu Lys Asn Lys  Val Asn Ser Asn Leu  Lys Ser Ser 
    1715                 1720                 1725             


Phe Asp  Glu Gln Phe Ala Val  Ser Asp Ser Ile Leu  Leu Ser Asn 
    1730                 1735                 1740             


Ser Phe  Val Ser Leu Leu Lys  Tyr Thr Ser Phe Gly  Ala Ser Gly 
    1745                 1750                 1755             


Gly Phe  Thr Phe Leu Asp Leu  Asp Val Lys Gln Gly  Arg Leu Arg 
    1760                 1765                 1770             


Tyr Gln  Thr Val Thr Glu Val  Leu Asp Ala Thr Leu  Ile Tyr Gln 
    1775                 1780                 1785             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Thr Asp Leu  Ser Gln Leu 
    1790                 1795                 1800             


Gly Gly  Asp 
    1805     


<210>  14
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Lys Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Met Asn Ile His Ser Gly Arg Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Ala Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser 
    210                 215             


<210>  15
<211>  1624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Lys Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Met Asn Ile His Ser Gly Arg Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Ala Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asn 
        275                 280                 285             


Arg Lys Ser Ile Lys Lys Asn Leu Met Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr Leu Gln Glu Ile Phe Ala 
                325                 330                 335     


Asn Glu Met Ala Lys Leu Asp Asp Ser Phe Phe Gln Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys Asn Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Leu Ala Asp Glu Val Ala Tyr His Arg Asn Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Ala Asp Ser Pro Glu Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu Asn Ser Asp Val Ala Lys 
            420                 425                 430         


Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn Gln Leu Phe Glu Glu Ser 
        435                 440                 445             


Pro Leu Asp Glu Ile Glu Val Asp Ala Lys Gly Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu Ile Ala Val Phe Pro Asn 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile Ile Ala Leu Ala Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Thr Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Glu Leu Leu 
        515                 520                 525             


Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Ser Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Ser Asn Ser Glu 
545                 550                 555                 560 


Val Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Ala Leu Leu Lys Thr Leu Val Arg Gln Gln Phe 
            580                 585                 590         


Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp Asp Thr Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Val Gly Ile Gly Ile Lys His Arg Lys Arg Thr Thr Lys 
    610                 615                 620                 


Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
625                 630                 635                 640 


Lys Met Asp Gly Ala Glu Glu Leu Leu Ala Lys Leu Asn Arg Asp Asp 
                645                 650                 655     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            660                 665                 670         


Ile His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Glu Phe 
        675                 680                 685             


Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    690                 695                 700                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
705                 710                 715                 720 


Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu Ala Ile Thr Pro Trp Asn 
                725                 730                 735     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            740                 745                 750         


Arg Met Thr Asn Phe Asp Glu Gln Leu Pro Asn Lys Lys Val Leu Pro 
        755                 760                 765             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    770                 775                 780                 


Lys Val Lys Tyr Val Thr Glu Arg Met Arg Lys Pro Glu Phe Leu Ser 
785                 790                 795                 800 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                805                 810                 815     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            820                 825                 830         


Cys Phe Asp Ser Val Glu Ile Ile Gly Val Glu Asp Arg Phe Asn Ala 
        835                 840                 845             


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
    850                 855                 860                 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
865                 870                 875                 880 


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
                885                 890                 895     


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
            900                 905                 910         


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Met Ile Asn Gly 
        915                 920                 925             


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
    930                 935                 940                 


Asp Gly Phe Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
945                 950                 955                 960 


Leu Thr Phe Lys Glu Glu Ile Glu Lys Ala Gln Val Ser Gly Gln Gly 
                965                 970                 975     


Asp Ser Leu His Glu Gln Ile Ala Asp Leu Ala Gly Ser Pro Ala Ile 
            980                 985                 990         


Lys Lys Gly Ile Leu Gln Thr Val  Lys Ile Val Asp Glu  Leu Val Lys 
        995                 1000                 1005             


Val Met  Gly His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1010                 1015                 1020             


Glu Asn  Gln Thr Thr Thr Lys  Gly Leu Gln Gln Ser  Arg Glu Arg 
    1025                 1030                 1035             


Lys Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Glu  Ser Gln Ile 
    1040                 1045                 1050             


Leu Lys  Glu Asn Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1070                 1075                 1080             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp Ala 
    1085                 1090                 1095             


Ile Val  Pro Gln Ser Phe Ile  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1100                 1105                 1110             


Val Leu  Thr Arg Ser Val Glu  Asn Arg Gly Lys Ser  Asp Asn Val 
    1115                 1120                 1125             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1130                 1135                 1140             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1145                 1150                 1155             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Ala Asp  Lys Ala Gly 
    1160                 1165                 1170             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1175                 1180                 1185             


Val Ala  Arg Ile Leu Asp Ser  Arg Met Asn Thr Lys  Arg Asp Lys 
    1190                 1195                 1200             


Asn Asp  Lys Pro Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1205                 1210                 1215             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Leu  Tyr Lys Val 
    1220                 1225                 1230             


Arg Asp  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1250                 1255                 1260             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1265                 1270                 1275             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1280                 1285                 1290             


Arg Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Val 
    1295                 1300                 1305             


Lys Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1310                 1315                 1320             


Asn Gly  Glu Thr Gly Glu Val  Val Trp Asn Lys Glu  Lys Asp Phe 
    1325                 1330                 1335             


Ala Thr  Val Arg Lys Val Leu  Ala Met Pro Gln Val  Asn Ile Val 
    1340                 1345                 1350             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1355                 1360                 1365             


Leu Ser  Lys Arg Glu Ser Ala  Lys Leu Ile Pro Arg  Lys Lys Gly 
    1370                 1375                 1380             


Trp Asp  Thr Arg Lys Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala 
    1385                 1390                 1395             


Tyr Ser  Ile Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ala Lys 
    1400                 1405                 1410             


Lys Leu  Lys Ser Val Lys Val  Leu Val Gly Ile Thr  Ile Met Glu 
    1415                 1420                 1425             


Lys Gly  Ser Tyr Glu Lys Asp  Pro Ile Gly Phe Leu  Glu Ala Lys 
    1430                 1435                 1440             


Gly Tyr  Lys Asp Ile Lys Lys  Glu Leu Ile Phe Lys  Leu Pro Lys 
    1445                 1450                 1455             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1460                 1465                 1470             


Ser Ala  Thr Glu Leu Gln Lys  Ala Asn Glu Leu Val  Leu Pro Gln 
    1475                 1480                 1485             


His Leu  Val Arg Leu Leu Tyr  Tyr Thr Gln Asn Ile  Ser Ala Thr 
    1490                 1495                 1500             


Thr Gly  Ser Asn Asn Leu Gly  Tyr Ile Glu Gln His  Arg Glu Glu 
    1505                 1510                 1515             


Phe Lys  Glu Ile Phe Glu Lys  Ile Ile Asp Phe Ser  Glu Lys Tyr 
    1520                 1525                 1530             


Ile Leu  Lys Asn Lys Val Asn  Ser Asn Leu Lys Ser  Ser Phe Asp 
    1535                 1540                 1545             


Glu Gln  Phe Ala Val Ser Asp  Ser Ile Leu Leu Ser  Asn Ser Phe 
    1550                 1555                 1560             


Val Ser  Leu Leu Lys Tyr Thr  Ser Phe Gly Ala Ser  Gly Gly Phe 
    1565                 1570                 1575             


Thr Phe  Leu Asp Leu Asp Val  Lys Gln Gly Arg Leu  Arg Tyr Gln 
    1580                 1585                 1590             


Thr Val  Thr Glu Val Leu Asp  Ala Thr Leu Ile Tyr  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Thr Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp 
    


<210>  16
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Lys Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Leu Asn Ile His Ser Gly Ala Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Ala Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser 
    210                 215             


<210>  17
<211>  1624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Met Ala Tyr Asp Tyr Ser Ala Ser Leu Asn Pro Gln Lys Ala Leu Ile 
1               5                   10                  15      


Trp Arg Ile Val His Arg Asp Asn Ile Pro Trp Ile Leu Asp Asn Gly 
            20                  25                  30          


Leu His Cys Gly Asn Ser Leu Val Gln Ala Glu Asn Trp Ile Asn Ile 
        35                  40                  45              


Asp Asn Pro Glu Leu Ile Gly Lys Arg Ala Gly His Pro Val Pro Val 
    50                  55                  60                  


Gly Thr Gly Gly Thr Leu His Asp Tyr Val Pro Phe Tyr Phe Thr Pro 
65                  70                  75                  80  


Phe Ser Pro Met Leu Leu Asn Ile His Ser Gly Ala Gly Gly Ile Lys 
                85                  90                  95      


Arg Arg Pro Asn Glu Glu Ile Val Ile Leu Val Ser Asn Leu Arg Asn 
            100                 105                 110         


Val Ala Ala His Asp Val Pro Phe Val Phe Thr Asp Ser His Ala Tyr 
        115                 120                 125             


Tyr Asn Trp Thr Asn Tyr Tyr Thr Ser Leu Asn Ser Leu Asp Gln Ile 
    130                 135                 140                 


Asp Trp Pro Ile Leu Gln Ala Arg Asp Phe Arg Arg Asp Pro Asp Asp 
145                 150                 155                 160 


Pro Ala Lys Phe Glu Arg Tyr Gln Ala Glu Ala Leu Ile Trp Gln His 
                165                 170                 175     


Cys Pro Ile Ser Leu Leu Asp Gly Ile Ile Cys Tyr Ser Glu Glu Val 
            180                 185                 190         


Ala Leu Gln Leu Glu Gln Trp Leu Phe Gln Arg Asn Leu Thr Met Ser 
        195                 200                 205             


Val His Thr Arg Ser Gly Trp Tyr Phe Ser Ser Gly Gly Ser Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
225                 230                 235                 240 


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Glu Lys Lys Tyr Ser Ile 
                245                 250                 255     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            260                 265                 270         


Asp Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asn 
        275                 280                 285             


Arg Lys Ser Ile Lys Lys Asn Leu Met Gly Ala Leu Leu Phe Asp Ser 
    290                 295                 300                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
305                 310                 315                 320 


Tyr Thr Arg Arg Lys Asn Arg Ile Arg Tyr Leu Gln Glu Ile Phe Ala 
                325                 330                 335     


Asn Glu Met Ala Lys Leu Asp Asp Ser Phe Phe Gln Arg Leu Glu Glu 
            340                 345                 350         


Ser Phe Leu Val Glu Glu Asp Lys Lys Asn Glu Arg His Pro Ile Phe 
        355                 360                 365             


Gly Asn Leu Ala Asp Glu Val Ala Tyr His Arg Asn Tyr Pro Thr Ile 
    370                 375                 380                 


Tyr His Leu Arg Lys Lys Leu Ala Asp Ser Pro Glu Lys Ala Asp Leu 
385                 390                 395                 400 


Arg Leu Ile Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
                405                 410                 415     


Phe Leu Ile Glu Gly Lys Leu Asn Ala Glu Asn Ser Asp Val Ala Lys 
            420                 425                 430         


Leu Phe Tyr Gln Leu Ile Gln Thr Tyr Asn Gln Leu Phe Glu Glu Ser 
        435                 440                 445             


Pro Leu Asp Glu Ile Glu Val Asp Ala Lys Gly Ile Leu Ser Ala Arg 
    450                 455                 460                 


Leu Ser Lys Ser Lys Arg Leu Glu Lys Leu Ile Ala Val Phe Pro Asn 
465                 470                 475                 480 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Ile Ile Ala Leu Ala Leu Gly 
                485                 490                 495     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Thr Glu Asp Ala Lys 
            500                 505                 510         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Glu Leu Leu 
        515                 520                 525             


Gly Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Ser Ala Ala Lys Asn 
    530                 535                 540                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Ser Asn Ser Glu 
545                 550                 555                 560 


Val Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Asp Glu 
                565                 570                 575     


His His Gln Asp Leu Ala Leu Leu Lys Thr Leu Val Arg Gln Gln Phe 
            580                 585                 590         


Pro Glu Lys Tyr Ala Glu Ile Phe Lys Asp Asp Thr Lys Asn Gly Tyr 
        595                 600                 605             


Ala Gly Tyr Val Gly Ile Gly Ile Lys His Arg Lys Arg Thr Thr Lys 
    610                 615                 620                 


Leu Ala Thr Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
625                 630                 635                 640 


Lys Met Asp Gly Ala Glu Glu Leu Leu Ala Lys Leu Asn Arg Asp Asp 
                645                 650                 655     


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
            660                 665                 670         


Ile His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Glu Phe 
        675                 680                 685             


Tyr Pro Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
    690                 695                 700                 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
705                 710                 715                 720 


Phe Ala Trp Leu Thr Arg Lys Ser Glu Glu Ala Ile Thr Pro Trp Asn 
                725                 730                 735     


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
            740                 745                 750         


Arg Met Thr Asn Phe Asp Glu Gln Leu Pro Asn Lys Lys Val Leu Pro 
        755                 760                 765             


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
    770                 775                 780                 


Lys Val Lys Tyr Val Thr Glu Arg Met Arg Lys Pro Glu Phe Leu Ser 
785                 790                 795                 800 


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
                805                 810                 815     


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
            820                 825                 830         


Cys Phe Asp Ser Val Glu Ile Ile Gly Val Glu Asp Arg Phe Asn Ala 
        835                 840                 845             


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
    850                 855                 860                 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
865                 870                 875                 880 


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
                885                 890                 895     


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
            900                 905                 910         


Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Met Ile Asn Gly 
        915                 920                 925             


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
    930                 935                 940                 


Asp Gly Phe Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
945                 950                 955                 960 


Leu Thr Phe Lys Glu Glu Ile Glu Lys Ala Gln Val Ser Gly Gln Gly 
                965                 970                 975     


Asp Ser Leu His Glu Gln Ile Ala Asp Leu Ala Gly Ser Pro Ala Ile 
            980                 985                 990         


Lys Lys Gly Ile Leu Gln Thr Val  Lys Ile Val Asp Glu  Leu Val Lys 
        995                 1000                 1005             


Val Met  Gly His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1010                 1015                 1020             


Glu Asn  Gln Thr Thr Thr Lys  Gly Leu Gln Gln Ser  Arg Glu Arg 
    1025                 1030                 1035             


Lys Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Glu  Ser Gln Ile 
    1040                 1045                 1050             


Leu Lys  Glu Asn Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1070                 1075                 1080             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp Ala 
    1085                 1090                 1095             


Ile Val  Pro Gln Ser Phe Ile  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1100                 1105                 1110             


Val Leu  Thr Arg Ser Val Glu  Asn Arg Gly Lys Ser  Asp Asn Val 
    1115                 1120                 1125             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1130                 1135                 1140             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1145                 1150                 1155             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Ala Asp  Lys Ala Gly 
    1160                 1165                 1170             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1175                 1180                 1185             


Val Ala  Arg Ile Leu Asp Ser  Arg Met Asn Thr Lys  Arg Asp Lys 
    1190                 1195                 1200             


Asn Asp  Lys Pro Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1205                 1210                 1215             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Leu  Tyr Lys Val 
    1220                 1225                 1230             


Arg Asp  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1250                 1255                 1260             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1265                 1270                 1275             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1280                 1285                 1290             


Arg Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Val 
    1295                 1300                 1305             


Lys Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1310                 1315                 1320             


Asn Gly  Glu Thr Gly Glu Val  Val Trp Asn Lys Glu  Lys Asp Phe 
    1325                 1330                 1335             


Ala Thr  Val Arg Lys Val Leu  Ala Met Pro Gln Val  Asn Ile Val 
    1340                 1345                 1350             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1355                 1360                 1365             


Leu Ser  Lys Arg Glu Ser Ala  Lys Leu Ile Pro Arg  Lys Lys Gly 
    1370                 1375                 1380             


Trp Asp  Thr Arg Lys Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala 
    1385                 1390                 1395             


Tyr Ser  Ile Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ala Lys 
    1400                 1405                 1410             


Lys Leu  Lys Ser Val Lys Val  Leu Val Gly Ile Thr  Ile Met Glu 
    1415                 1420                 1425             


Lys Gly  Ser Tyr Glu Lys Asp  Pro Ile Gly Phe Leu  Glu Ala Lys 
    1430                 1435                 1440             


Gly Tyr  Lys Asp Ile Lys Lys  Glu Leu Ile Phe Lys  Leu Pro Lys 
    1445                 1450                 1455             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Arg Arg  Met Leu Ala 
    1460                 1465                 1470             


Ser Ala  Thr Glu Leu Gln Lys  Ala Asn Glu Leu Val  Leu Pro Gln 
    1475                 1480                 1485             


His Leu  Val Arg Leu Leu Tyr  Tyr Thr Gln Asn Ile  Ser Ala Thr 
    1490                 1495                 1500             


Thr Gly  Ser Asn Asn Leu Gly  Tyr Ile Glu Gln His  Arg Glu Glu 
    1505                 1510                 1515             


Phe Lys  Glu Ile Phe Glu Lys  Ile Ile Asp Phe Ser  Glu Lys Tyr 
    1520                 1525                 1530             


Ile Leu  Lys Asn Lys Val Asn  Ser Asn Leu Lys Ser  Ser Phe Asp 
    1535                 1540                 1545             


Glu Gln  Phe Ala Val Ser Asp  Ser Ile Leu Leu Ser  Asn Ser Phe 
    1550                 1555                 1560             


Val Ser  Leu Leu Lys Tyr Thr  Ser Phe Gly Ala Ser  Gly Gly Phe 
    1565                 1570                 1575             


Thr Phe  Leu Asp Leu Asp Val  Lys Gln Gly Arg Leu  Arg Tyr Gln 
    1580                 1585                 1590             


Thr Val  Thr Glu Val Leu Asp  Ala Thr Leu Ile Tyr  Gln Ser Ile 
    1595                 1600                 1605             


Thr Gly  Leu Tyr Glu Thr Arg  Thr Asp Leu Ser Gln  Leu Gly Gly 
    1610                 1615                 1620             


Asp 
    


<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be L, I, V, or A

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be I, Q, K, T, or N

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Xaa Xaa Xaa Xaa Arg 
1               5   


<210>  19
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be L, V, or I

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be H, G, N, S, or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be D or E

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be Y or F

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be V, I, or A

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be T, A, G, K, N, or W

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be S, T, N, M, or K

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be P, V, M, I, A

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be L, M or F

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Phe Tyr Phe Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Met Xaa Xaa 
            20      


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be F, Y, W, V, or C

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be V, L, I, A, C, or F

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be F, Y, or A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be T, S, Y, or F

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be D, N, or S

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be G, R, S, A, M or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be H, N, S, or Q

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A, G, C, H or K

<400>  20

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  21
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be R, K, H, E, F, L, T, or M

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be Y, R, K, D, E, or H

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be Q, M, E, Y, A, R, or H;

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be A Q, S, or Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be E, A, or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be F, A, L, E, V, or C

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be L, A, E, or M

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be V, I, L, or A

<400>  21

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  22
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be Q, E, or R

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be V or I

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be A, L, V, S, or T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be F, I, V, or L

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be P, A, or I

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be I, V, or L

<400>  22

Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Xaa Gly Gly Xaa 
1               5                   10                  


<210>  23
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be S, T, or G

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be F, Y, or L

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be V, I, A, or L

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be S, G, or A

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be T or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be T, S, or A

<400>  23

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be L or V

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be R, H, or K

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be D, S, or A

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be R or D

<400>  24

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  25
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be S or L

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be H, G, K, R, N, D, or A

<400>  25

Xaa His Tyr Xaa Xaa 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be L, I, or F

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be N, G, S, or T

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be R or K

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be M, L, or A

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be W, A, C, V, F, or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be L, I, F, M, V, C, or T

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be D or E

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be L ,A, M, C, V, Q, or T

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be P, G, A, or L

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be R, K, H, T, or M

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be N or F

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be S, A, T, or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be S or T

<400>  26

Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu 
1               5                   10                  15      


Xaa 
    


<210>  27
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be F, W, Y, or M

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be A or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be E, G, P, A, or T

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be G, C, or Q

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be T, V, Y, or I

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be V or I

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be Q, K, or R

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A, S, C, T, or N

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be N, G, or A

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be F, W, or Y

<400>  27

Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Tyr Xaa Ala Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  28
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  28
tggaaaactg tgggtagtag gagggcaaag tgtacaa                                37


<210>  29
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  29
caaaagtaag ggcgagaaat attgatagta aagaggtcac gaggttgtt                   49


<210>  30
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  30
tttccgttga taaacgttgc tgcataa                                           27


<210>  31
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  31
tttaatgaat gaaacagccg cgctgta                                           27


<210>  32
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  32
ccggctgtgc cgtgagccac catcaaa                                           27


<210>  33
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  33
tttgccgtaa tagtaagacc tgagcgc                                           27


<210>  34
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  34
cgttgctgca ttgataatct acacaaa                                           27


<210>  35
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  35
ttccggcacg ttgatcggtg ccggaaa                                           27


<210>  36
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  36
gtctcaattc atgggtcaaa ataaccc                                           27


<210>  37
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  37
gtctcaattc atgggtcaaa acaaccc                                           27


<210>  38
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  38
gtctcaattc atgggtcaaa ataaccc                                           27


