                         SEQUENCE LISTING

<110>  UNIVERSITY OF ARIZONA
       WON, Young-Wook
       HAN, Seungmin
       BULL, David A
 
<120>  RECOMBINANT EOMES RESTORES ANTI-CANCER ACTIVITY OF IMMUNE CELLS

<130>  212443-9012-US01

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atgcctaaaa agaaaaggaa ggttggtggg ggaggatcag ctcacgttta tctgtgcaac       60

cgcccgctgt ggctgaagtt ccatcgtcac cagaccgaga tgatcattac caaacaaggt      120

cgtcgtatgt tcccgtttct gagcttcaac atcaacggcc tgaacccgac cgcgcactac      180

aacgtgttcg ttgaagtggt tctggcggac ccgaaccact ggcgttttca gggtggcaaa      240

tgggttacct gcggcaaggc ggataacaac atgcaaggca acaagatgta tgtgcacccg      300

gagagcccga acaccggtag ccactggatg cgtcaggaaa ttagctttgg caagctgaaa      360

ctgaccaaca acaaaggcgc gaacaacaac aacacccaga tgatcgttct gcaaagcctg      420

cacaagtacc aaccgcgtct gcacattgtg gaggttaccg aagacggcgt ggaggatctg      480

aacgaaccga gcaaaaccca gaccttcacc tttagcgaaa cccaattcat cgcggttacc      540

gcgtaccaga acaccgacat cacccaactg aaaattgatc acaacccgtt cgcgaagggt      600

tttcgtgaca actacgatag cagccaccag attgtgccgg gtggccgtta tggcgttcag      660

agcttcttcc cggagccgtt tgtgaacacc ctgccgcagg cgcgttacta taacggtgaa      720

cgtaccgttc cgcaaaccaa cggcctgctg agcccgcagc aaagcgagga agtggcgaac      780

ccgccgcagc gttggctggt gaccccggtt cagcaaccgg gtaccaacaa actggacatc      840

agcagctacg agagcgaata taccagcagc accctgctgc cgtacggtat taagagcctg      900

ccgctgcaga ccagccatgc gctgggctac tatccggatc cgacctttcc ggcgatggcg      960

ggttggggtg gccgtggcag ctatcagcgt aaaatggcgg cgggtctgcc gtggaccagc     1020

cgtaccagcc cgaccgtgtt tagcgaggac caactgagca aggaaaaagt taaagaggag     1080

atcggtagca gctggattga aaccccgccg agcatcaaaa gcctggacag caacgatagc     1140

ggcgtgtaca ccagcgcgtg caagcgtcgt cgtctgagcc cgagcaacag cagcaacgag     1200

aacagcccga gcatcaagtg cgaagacatt aacgcggagg aatatagcaa agataccagc     1260

aagggtatgg gtggctacta tgcgttttac accaccccgg gtggcggtgg cagctatggc     1320

cgtaagaagc gtcgtcagcg tcgtcgcggc ggcggcggca gccatcacca tcaccatcac     1380

ggttaatga                                                             1389


<210>  2
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(8)
<223>  Nuclear Localization Signal

<220>
<221>  MISC_FEATURE
<222>  (8)..(13)
<223>  Glycine linker

<220>
<221>  MISC_FEATURE
<222>  (14)..(433)
<223>  Eomes polypeptide

<220>
<221>  MISC_FEATURE
<222>  (433)..(438)
<223>  Glycine linker

<220>
<221>  MISC_FEATURE
<222>  (439)..(449)
<223>  TAT cell-penetrating peptide

<220>
<221>  MISC_FEATURE
<222>  (450)..(455)
<223>  Glycine linker

<220>
<221>  MISC_FEATURE
<222>  (455)..(460)
<223>  Histidine 6x Tag

<400>  2

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Ala His Val 
1               5                   10                  15      


Tyr Leu Cys Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr 
            20                  25                  30          


Glu Met Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser 
        35                  40                  45              


Phe Asn Ile Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val 
    50                  55                  60                  


Glu Val Val Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys 
65                  70                  75                  80  


Trp Val Thr Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met 
                85                  90                  95      


Tyr Val His Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln 
            100                 105                 110         


Glu Ile Ser Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn 
        115                 120                 125             


Asn Asn Asn Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln 
    130                 135                 140                 


Pro Arg Leu His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu 
145                 150                 155                 160 


Asn Glu Pro Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe 
                165                 170                 175     


Ile Ala Val Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile 
            180                 185                 190         


Asp His Asn Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser 
        195                 200                 205             


His Gln Ile Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro 
    210                 215                 220                 


Glu Pro Phe Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu 
225                 230                 235                 240 


Arg Thr Val Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu 
                245                 250                 255     


Glu Val Ala Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln 
            260                 265                 270         


Pro Gly Thr Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr 
        275                 280                 285             


Ser Ser Thr Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr 
    290                 295                 300                 


Ser His Ala Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala 
305                 310                 315                 320 


Gly Trp Gly Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu 
                325                 330                 335     


Pro Trp Thr Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu 
            340                 345                 350         


Ser Lys Glu Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr 
        355                 360                 365             


Pro Pro Ser Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr 
    370                 375                 380                 


Ser Ala Cys Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu 
385                 390                 395                 400 


Asn Ser Pro Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser 
                405                 410                 415     


Lys Asp Thr Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr 
            420                 425                 430         


Pro Gly Gly Gly Gly Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg 
        435                 440                 445             


Arg Gly Gly Gly Gly Ser His His His His His His Gly 
    450                 455                 460     


<210>  3
<211>  2061
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcagttag gggagcagct cttggtgagc tcagtgaacc tgcctggcgc gcacttctac       60

ccgctggaga gtgcgcgagg cggcagcggc gggagcgctg gccacctccc cagcgcggcc      120

ccctctcctc agaagttgga cttagacaaa gcgtccaaga agttttccgg cagtctctcc      180

tgcgaggcgg tgagcgggga gcccgcagcc gccagcgcag gggcccccgc ggccatgctt      240

agtgacaccg acgccgggga cgcatttgcc agcgctgcgg cagtggccaa gccggggccc      300

ccggacggcc gcaagggctc cccctgcggg gaggaggagc tgccctccgc cgctgcagcc      360

gccgccgccg ccgccgccgc ggctgcggcc actgcgcgct actccatgga cagcctgagc      420

tccgagcggt actacctcca gtcccccggt cctcaggggt cggagctggc tgcgccctgc      480

tcactcttcc cgtaccaggc ggcggctggg gcgccccacg gacctgtgta cccggctcct      540

aacggggcgc gctaccccta cggctccatg ctgccccccg gcggcttccc cgcggctgtg      600

tgcccacccg ggagggcgca gttcggccca ggagccggtg cgggcagtgg cgcgggcggt      660

agcagcggcg ggggcggcgg cccgggcacc tatcagtaca gccagggggc tccgctctac      720

gggccgtacc ctggagccgc agcggcggga tcttgcggag gactgggggg cctgggggtt      780

ccaggttctg gcttccgtgc ccacgtctac ctgtgcaacc ggcctctgtg gctcaaattc      840

caccgccacc aaactgagat gatcattacg aaacagggca ggcgcatgtt tcctttcttg      900

agcttcaaca taaacggact caatcccact gcccactaca atgtgttcgt agaggtggtg      960

ctggcggacc ccaaccactg gcgcttccag gggggcaaat gggtgacctg tggcaaagcc     1020

gacaataaca tgcagggcaa caaaatgtat gttcacccag agtctcctaa tactggttcc     1080

cactggatga gacaggagat ttcattcggg aaattaaaac tcaccaataa caaaggcgca     1140

aataacaaca acacccagat gatagtctta caatccttac acaaatacca accccgactg     1200

catattgttg aagttacaga ggatggcgtg gaggacttga atgagccctc aaagacccag     1260

acttttacct tctcagaaac gcaattcatt gcagtgactg cctaccaaaa caccgatatt     1320

actcaactaa agattgatca taaccccttt gcaaaaggct tcagagacaa ctatgattca     1380

tcccatcaga ttgtccctgg aggtcggtac ggcgttcaat ccttcttccc ggagcccttt     1440

gtcaacactt tacctcaagc ccgctattat aatggcgaga gaaccgtgcc acagaccaac     1500

ggcctccttt caccccaaca gagcgaagag gtggccaacc ctccccagcg gtggcttgtc     1560

acgcctgtcc agcaacctgg gaccaacaaa ctagacatca gttcctatga atctgaatat     1620

acttctagca cattgctccc atatggcatt aaatccttgc cccttcagac atcccatgcc     1680

ctggggtatt acccagaccc aacctttcct gcaatggcag ggtggggagg tcgaggttct     1740

taccagagga agatggcagc tggactacca tggacctcca gaacaagccc cactgtgttc     1800

tctgaagatc agctctccaa ggagaaagtg aaagaggaaa ttggctcttc ttggatagag     1860

acaccccctt ccatcaaatc tctagattcc aatgattcag gagtatacac cagtgcttgt     1920

aagcgaaggc ggctgtctcc tagcaactcc agtaatgaaa attcaccctc cataaagtgt     1980

gaggacatta atgctgaaga gtatagtaaa gacacctcaa aaggcatggg agggtattat     2040

gctttttaca caactcccta a                                               2061


<210>  4
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser His Gln Ile 
    450                 455                 460                 


Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro Glu Pro Phe 
465                 470                 475                 480 


Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu Arg Thr Val 
                485                 490                 495     


Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu Glu Val Ala 
            500                 505                 510         


Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln Pro Gly Thr 
        515                 520                 525             


Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr Ser Ser Thr 
    530                 535                 540                 


Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr Ser His Ala 
545                 550                 555                 560 


Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala Gly Trp Gly 
                565                 570                 575     


Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu Pro Trp Thr 
            580                 585                 590         


Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu Ser Lys Glu 
        595                 600                 605             


Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr Pro Pro Ser 
    610                 615                 620                 


Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr Ser Ala Cys 
625                 630                 635                 640 


Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu Asn Ser Pro 
                645                 650                 655     


Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser Lys Asp Thr 
            660                 665                 670         


Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr Pro 
        675                 680                 685     


<210>  5
<211>  2124
<212>  DNA
<213>  Mus musculus

<400>  5
atgcagttgg gagagcagct cctggtgagc tcggtgaacc tgcccggcgc gcacttctac       60

tcgctggaga gtgctcgcgg aggaggagga ggaggaggcg gaggaggagg gggaggcgga      120

gggagcgtca gcctcctccc cggtgctgcc ccctcgcccc agaggctgga cttagacaaa      180

gcgtccaaga agtttccggg cagtctcccg tgccaggcgg ggagcgcaga acccgcaggc      240

gccggcgcgg gggcccccgc ggccatgctc agtgacgcgg acgctgggga caccttcggg      300

agcacctcgg cggtggccaa gcccgggccc ccggacggcc gcaagggctc cccgtgcgcg      360

gaggaggagc tgccctccgc cgccaccgcc gcggccaccg cgcgctactc catggacagc      420

ctgagctccg agcgctacta cctcccgtcg ccgggaccgc agggctccga gctcgccgcg      480

ccctgctcgc tcttccagta cccggcggcg gccggagcag cccacggacc cgtgtacccc      540

gcgtccaatg gcgcgcgcta cccctacggc tccatgctgc cccccggtgg attccccgcc      600

gccgtgtgcc cgcccgcgag ggcgcagttc ggccccgctg cgggttcggg gagcggcgct      660

ggtagcagcg gcggtggtgc cggcggtcct ggcgcctatc cctacggcca gggttctccg      720

ctctacgggc catacgccgg aacctcagcg gccgggtctt gtggaggatt ggggggccta      780

ggggtgcctg gctccggctt ccgcgcccac gtctacctgt gcaaccggcc cctatggctc      840

aaattccacc ggcaccaaac tgagatgatc atcaccaaac agggcaggcg catgtttcct      900

ttcttgagct tcaacataaa cggactcaac cccaccgccc actacaatgt tttcgtggaa      960

gtggttctgg ccgaccctaa ccactggcgc ttccaggggg gcaagtgggt gacctgcggc     1020

aaagcggaca ataacatgca gggcaataag atgtacgttc acccagaatc tcctaacact     1080

ggctcccact ggatgaggca ggagatttcc tttgggaagt taaaactcac caataacaaa     1140

ggtgcaaaca acaacaacac acagatgata gtgttgcagt ctctgcacaa ataccaaccg     1200

aggctgcaca tcgtggaagt gacagaggac ggtgtggagg acttgaatga accttccaag     1260

actcagacct tcaccttctc agagacacag ttcatcgctg tgacggccta ccaaaacacg     1320

gatatcaccc agctaaagat cgaccataac cccttcgcca aaggcttccg ggacaactac     1380

gattccatgt acacggcttc agaaaatgac aggttaactc catctcccac ggattcccct     1440

agatcccatc agattgtccc tggaggtcgg tacggcgttc aaaacttctt cccggagccc     1500

tttgtcaaca ctttgcctca agcccgatat tataacggtg agagaaccgt gccacagacc     1560

aacggcctcc tctcacccca acagagcgaa gaggtggcca accctcccca gcggtggctt     1620

gtcacgcctg tccagcaacc tgtgaccaac aagctagaca tcggttctta tgaatctgaa     1680

tatacttcca gtaccttgct cccatatggt attaagtcct tgcccctgca gacatcccat     1740

gccctggggt attaccctga cccgaccttc cctgctatgg cagggtgggg aggccgtggc     1800

gcttatcaga ggaagatggc agctggacta ccatggacat ccagaatgag cccacctgtc     1860

ttcccagaag atcagcttgc caaggaaaaa gttaaagaag agattagttc ctcctggata     1920

gagactcccc cctccatcaa gtctctagac tccagcgact ccggggtgta caacagcgct     1980

tgcaagagaa agcgcctgtc tcccagcacc cccagcaatg gaaactcgcc ccccataaag     2040

tgtgaggaca ttaacactga agagtacagt aaagacacct ccaaaggcat gggggcttat     2100

tatgcttttt acacaagtcc ctag                                            2124


<210>  6
<211>  707
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Ser Leu Glu Ser Ala Arg Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Val Ser Leu Leu Pro Gly 
        35                  40                  45              


Ala Ala Pro Ser Pro Gln Arg Leu Asp Leu Asp Lys Ala Ser Lys Lys 
    50                  55                  60                  


Phe Pro Gly Ser Leu Pro Cys Gln Ala Gly Ser Ala Glu Pro Ala Gly 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Pro Ala Ala Met Leu Ser Asp Ala Asp Ala Gly 
                85                  90                  95      


Asp Thr Phe Gly Ser Thr Ser Ala Val Ala Lys Pro Gly Pro Pro Asp 
            100                 105                 110         


Gly Arg Lys Gly Ser Pro Cys Ala Glu Glu Glu Leu Pro Ser Ala Ala 
        115                 120                 125             


Thr Ala Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu 
    130                 135                 140                 


Arg Tyr Tyr Leu Pro Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala 
145                 150                 155                 160 


Pro Cys Ser Leu Phe Gln Tyr Pro Ala Ala Ala Gly Ala Ala His Gly 
                165                 170                 175     


Pro Val Tyr Pro Ala Ser Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met 
            180                 185                 190         


Leu Pro Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Ala Arg Ala 
        195                 200                 205             


Gln Phe Gly Pro Ala Ala Gly Ser Gly Ser Gly Ala Gly Ser Ser Gly 
    210                 215                 220                 


Gly Gly Ala Gly Gly Pro Gly Ala Tyr Pro Tyr Gly Gln Gly Ser Pro 
225                 230                 235                 240 


Leu Tyr Gly Pro Tyr Ala Gly Thr Ser Ala Ala Gly Ser Cys Gly Gly 
                245                 250                 255     


Leu Gly Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr 
            260                 265                 270         


Leu Cys Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu 
        275                 280                 285             


Met Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe 
    290                 295                 300                 


Asn Ile Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu 
305                 310                 315                 320 


Val Val Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp 
                325                 330                 335     


Val Thr Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr 
            340                 345                 350         


Val His Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu 
        355                 360                 365             


Ile Ser Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn 
    370                 375                 380                 


Asn Asn Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro 
385                 390                 395                 400 


Arg Leu His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn 
                405                 410                 415     


Glu Pro Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile 
            420                 425                 430         


Ala Val Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp 
        435                 440                 445             


His Asn Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Met Tyr 
    450                 455                 460                 


Thr Ala Ser Glu Asn Asp Arg Leu Thr Pro Ser Pro Thr Asp Ser Pro 
465                 470                 475                 480 


Arg Ser His Gln Ile Val Pro Gly Gly Arg Tyr Gly Val Gln Asn Phe 
                485                 490                 495     


Phe Pro Glu Pro Phe Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn 
            500                 505                 510         


Gly Glu Arg Thr Val Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln 
        515                 520                 525             


Ser Glu Glu Val Ala Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val 
    530                 535                 540                 


Gln Gln Pro Val Thr Asn Lys Leu Asp Ile Gly Ser Tyr Glu Ser Glu 
545                 550                 555                 560 


Tyr Thr Ser Ser Thr Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu 
                565                 570                 575     


Gln Thr Ser His Ala Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala 
            580                 585                 590         


Met Ala Gly Trp Gly Gly Arg Gly Ala Tyr Gln Arg Lys Met Ala Ala 
        595                 600                 605             


Gly Leu Pro Trp Thr Ser Arg Met Ser Pro Pro Val Phe Pro Glu Asp 
    610                 615                 620                 


Gln Leu Ala Lys Glu Lys Val Lys Glu Glu Ile Ser Ser Ser Trp Ile 
625                 630                 635                 640 


Glu Thr Pro Pro Ser Ile Lys Ser Leu Asp Ser Ser Asp Ser Gly Val 
                645                 650                 655     


Tyr Asn Ser Ala Cys Lys Arg Lys Arg Leu Ser Pro Ser Thr Pro Ser 
            660                 665                 670         


Asn Gly Asn Ser Pro Pro Ile Lys Cys Glu Asp Ile Asn Thr Glu Glu 
        675                 680                 685             


Tyr Ser Lys Asp Thr Ser Lys Gly Met Gly Ala Tyr Tyr Ala Phe Tyr 
    690                 695                 700                 


Thr Ser Pro 
705         


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Asp 
            20  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is K or R

<400>  12

Lys Xaa Xaa Xaa 
1               


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10                  


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Leu 
            20                  25      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Leu Cys Leu Arg Pro Val Gly 
1               5           


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  Optional; length can be 8, 9, or 10 residues

<400>  17

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  Optional; length can be 8, 9, or 10 residues

<400>  18

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10  


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Pro Leu Ile Leu Leu Arg Leu Leu Arg Gly Gln Phe 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Pro Leu Ile Tyr Leu Arg Leu Leu Arg Gly Gln Phe 
1               5                   10          


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Lys Leu Trp Met Arg Trp Tyr Ser Pro Thr Thr Arg Arg Tyr Gly 
1               5                   10                  15  


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Arg Arg Ile Pro Asn Arg Arg Pro Arg Arg 
1               5                   10  


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Gly Gly Gly Gly Ser 
1               5   


<210>  29
<211>  6642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatgtcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatcga tctcgatccc     4980

gcgaaattaa tacgactcac tataggggaa ttgtgagcgg ataacaattc ccctctagaa     5040

ataattttgt ttaactttaa gaaggagata tacatatgcc taaaaagaaa aggaaggttg     5100

gtgggggagg atcagctcac gtttatctgt gcaaccgccc gctgtggctg aagttccatc     5160

gtcaccagac cgagatgatc attaccaaac aaggtcgtcg tatgttcccg tttctgagct     5220

tcaacatcaa cggcctgaac ccgaccgcgc actacaacgt gttcgttgaa gtggttctgg     5280

cggacccgaa ccactggcgt tttcagggtg gcaaatgggt tacctgcggc aaggcggata     5340

acaacatgca aggcaacaag atgtatgtgc acccggagag cccgaacacc ggtagccact     5400

ggatgcgtca ggaaattagc tttggcaagc tgaaactgac caacaacaaa ggcgcgaaca     5460

acaacaacac ccagatgatc gttctgcaaa gcctgcacaa gtaccaaccg cgtctgcaca     5520

ttgtggaggt taccgaagac ggcgtggagg atctgaacga accgagcaaa acccagacct     5580

tcacctttag cgaaacccaa ttcatcgcgg ttaccgcgta ccagaacacc gacatcaccc     5640

aactgaaaat tgatcacaac ccgttcgcga agggttttcg tgacaactac gatagcagcc     5700

accagattgt gccgggtggc cgttatggcg ttcagagctt cttcccggag ccgtttgtga     5760

acaccctgcc gcaggcgcgt tactataacg gtgaacgtac cgttccgcaa accaacggcc     5820

tgctgagccc gcagcaaagc gaggaagtgg cgaacccgcc gcagcgttgg ctggtgaccc     5880

cggttcagca accgggtacc aacaaactgg acatcagcag ctacgagagc gaatatacca     5940

gcagcaccct gctgccgtac ggtattaaga gcctgccgct gcagaccagc catgcgctgg     6000

gctactatcc ggatccgacc tttccggcga tggcgggttg gggtggccgt ggcagctatc     6060

agcgtaaaat ggcggcgggt ctgccgtgga ccagccgtac cagcccgacc gtgtttagcg     6120

aggaccaact gagcaaggaa aaagttaaag aggagatcgg tagcagctgg attgaaaccc     6180

cgccgagcat caaaagcctg gacagcaacg atagcggcgt gtacaccagc gcgtgcaagc     6240

gtcgtcgtct gagcccgagc aacagcagca acgagaacag cccgagcatc aagtgcgaag     6300

acattaacgc ggaggaatat agcaaagata ccagcaaggg tatgggtggc tactatgcgt     6360

tttacaccac cccgggtggc ggtggcagct atggccgtaa gaagcgtcgt cagcgtcgtc     6420

gcggcggcgg cggcagccat caccatcacc atcacggtta atgaaagctt gcggccgcac     6480

tcgagcacca ccaccaccac cactgagatc cggctgctaa caaagcccga aaggaagctg     6540

agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg     6600

tcttgagggg ttttttgctg aaaggaggaa ctatatccgg at                        6642


