                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Immunomodulators Targeting MORC3 for Interferon Induction

<130>  034044.224WO1

<150>  US 63/148,775
<151>  2021-02-12

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  939
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MORC3 protein

<400>  1

Met Ala Ala Gln Pro Pro Arg Gly Ile Arg Leu Ser Ala Leu Cys Pro 
1               5                   10                  15      


Lys Phe Leu His Thr Asn Ser Thr Ser His Thr Trp Pro Phe Ser Ala 
            20                  25                  30          


Val Ala Glu Leu Ile Asp Asn Ala Tyr Asp Pro Asp Val Asn Ala Lys 
        35                  40                  45              


Gln Ile Trp Ile Asp Lys Thr Val Ile Asn Asp His Ile Cys Leu Thr 
    50                  55                  60                  


Phe Thr Asp Asn Gly Asn Gly Met Thr Ser Asp Lys Leu His Lys Met 
65                  70                  75                  80  


Leu Ser Phe Gly Phe Ser Asp Lys Val Thr Met Asn Gly His Val Pro 
                85                  90                  95      


Val Gly Leu Tyr Gly Asn Gly Phe Lys Ser Gly Ser Met Arg Leu Gly 
            100                 105                 110         


Lys Asp Ala Ile Val Phe Thr Lys Asn Gly Glu Ser Met Ser Val Gly 
        115                 120                 125             


Leu Leu Ser Gln Thr Tyr Leu Glu Val Ile Lys Ala Glu His Val Val 
    130                 135                 140                 


Val Pro Ile Val Ala Phe Asn Lys His Arg Gln Met Ile Asn Leu Ala 
145                 150                 155                 160 


Glu Ser Lys Ala Ser Leu Ala Ala Ile Leu Glu His Ser Leu Phe Ser 
                165                 170                 175     


Thr Glu Gln Lys Leu Leu Ala Glu Leu Asp Ala Ile Ile Gly Lys Lys 
            180                 185                 190         


Gly Thr Arg Ile Ile Ile Trp Asn Leu Arg Ser Tyr Lys Asn Ala Thr 
        195                 200                 205             


Glu Phe Asp Phe Glu Lys Asp Lys Tyr Asp Ile Arg Ile Pro Glu Asp 
    210                 215                 220                 


Leu Asp Glu Ile Thr Gly Lys Lys Gly Tyr Lys Lys Gln Glu Arg Met 
225                 230                 235                 240 


Asp Gln Ile Ala Pro Glu Ser Asp Tyr Ser Leu Arg Ala Tyr Cys Ser 
                245                 250                 255     


Ile Leu Tyr Leu Lys Pro Arg Met Gln Ile Ile Leu Arg Gly Gln Lys 
            260                 265                 270         


Val Lys Thr Gln Leu Val Ser Lys Ser Leu Ala Tyr Ile Glu Arg Asp 
        275                 280                 285             


Val Tyr Arg Pro Lys Phe Leu Ser Lys Thr Val Arg Ile Thr Phe Gly 
    290                 295                 300                 


Phe Asn Cys Arg Asn Lys Asp His Tyr Gly Ile Met Met Tyr His Arg 
305                 310                 315                 320 


Asn Arg Leu Ile Lys Ala Tyr Glu Lys Val Gly Cys Gln Leu Arg Ala 
                325                 330                 335     


Asn Asn Met Gly Val Gly Val Val Gly Ile Ile Glu Cys Asn Phe Leu 
            340                 345                 350         


Lys Pro Thr His Asn Lys Gln Asp Phe Asp Tyr Thr Asn Glu Tyr Arg 
        355                 360                 365             


Leu Thr Ile Thr Ala Leu Gly Glu Lys Leu Asn Asp Tyr Trp Asn Glu 
    370                 375                 380                 


Met Lys Val Lys Lys Asn Thr Glu Tyr Pro Leu Asn Leu Pro Val Glu 
385                 390                 395                 400 


Asp Ile Gln Lys Arg Pro Asp Gln Thr Trp Val Gln Cys Asp Ala Cys 
                405                 410                 415     


Leu Lys Trp Arg Lys Leu Pro Asp Gly Met Asp Gln Leu Pro Glu Lys 
            420                 425                 430         


Trp Tyr Cys Ser Asn Asn Pro Asp Pro Gln Phe Arg Asn Cys Glu Val 
        435                 440                 445             


Pro Glu Glu Pro Glu Asp Glu Asp Leu Val His Pro Thr Tyr Glu Lys 
    450                 455                 460                 


Thr Tyr Lys Lys Thr Asn Lys Glu Lys Phe Arg Ile Arg Gln Pro Glu 
465                 470                 475                 480 


Met Ile Pro Arg Ile Asn Ala Glu Leu Leu Phe Arg Pro Thr Ala Leu 
                485                 490                 495     


Ser Thr Pro Ser Phe Ser Ser Pro Lys Glu Ser Val Pro Arg Arg His 
            500                 505                 510         


Leu Ser Glu Gly Thr Asn Ser Tyr Ala Thr Arg Leu Leu Asn Asn His 
        515                 520                 525             


Gln Val Pro Pro Gln Ser Glu Pro Glu Ser Asn Ser Leu Lys Arg Arg 
    530                 535                 540                 


Leu Ser Thr Arg Ser Ser Ile Leu Asn Ala Lys Asn Arg Arg Leu Ser 
545                 550                 555                 560 


Ser Gln Phe Glu Asn Ser Val Tyr Lys Gly Asp Asp Asp Asp Glu Asp 
                565                 570                 575     


Val Ile Ile Leu Glu Glu Asn Ser Thr Pro Lys Pro Ala Val Asp His 
            580                 585                 590         


Asp Ile Asp Met Lys Ser Glu Gln Ser His Val Glu Gln Gly Gly Val 
        595                 600                 605             


Gln Val Glu Phe Val Gly Asp Ser Glu Pro Cys Gly Gln Thr Gly Ser 
    610                 615                 620                 


Thr Ser Thr Ser Ser Ser Arg Cys Asp Gln Gly Asn Thr Ala Ala Thr 
625                 630                 635                 640 


Gln Thr Glu Val Pro Ser Leu Val Val Lys Lys Glu Glu Thr Val Glu 
                645                 650                 655     


Asp Glu Ile Asp Val Arg Asn Asp Ala Val Ile Leu Pro Ser Cys Val 
            660                 665                 670         


Glu Ala Glu Ala Lys Ile His Glu Thr Gln Glu Thr Thr Asp Lys Ser 
        675                 680                 685             


Ala Asp Asp Ala Gly Cys Gln Leu Gln Glu Leu Arg Asn Gln Leu Leu 
    690                 695                 700                 


Leu Val Thr Glu Glu Lys Glu Asn Tyr Lys Arg Gln Cys His Met Phe 
705                 710                 715                 720 


Thr Asp Gln Ile Lys Val Leu Gln Gln Arg Ile Leu Glu Met Asn Asp 
                725                 730                 735     


Lys Tyr Val Lys Lys Glu Thr Cys His Gln Ser Thr Glu Thr Asp Ala 
            740                 745                 750         


Val Phe Leu Leu Glu Ser Ile Asn Gly Lys Ser Glu Ser Pro Asp His 
        755                 760                 765             


Met Val Ser Gln Tyr Gln Gln Ala Leu Glu Glu Ile Glu Arg Leu Lys 
    770                 775                 780                 


Lys Gln Cys Ser Ala Leu Gln His Val Lys Ala Glu Cys Ser Gln Cys 
785                 790                 795                 800 


Ser Asn Asn Glu Ser Lys Ser Glu Met Asp Glu Met Ala Val Gln Leu 
                805                 810                 815     


Asp Asp Val Phe Arg Gln Leu Asp Lys Cys Ser Ile Glu Arg Asp Gln 
            820                 825                 830         


Tyr Lys Ser Glu Val Glu Leu Leu Glu Met Glu Lys Ser Gln Ile Arg 
        835                 840                 845             


Ser Gln Cys Glu Glu Leu Lys Thr Glu Val Glu Gln Leu Lys Ser Thr 
    850                 855                 860                 


Asn Gln Gln Thr Ala Thr Asp Val Ser Thr Ser Ser Asn Ile Glu Glu 
865                 870                 875                 880 


Ser Val Asn His Met Asp Gly Glu Ser Leu Lys Leu Arg Ser Leu Arg 
                885                 890                 895     


Val Asn Val Gly Gln Leu Leu Ala Met Ile Val Pro Asp Leu Asp Leu 
            900                 905                 910         


Gln Gln Val Asn Tyr Asp Val Asp Val Val Asp Glu Ile Leu Gly Gln 
        915                 920                 925             


Val Val Glu Gln Met Ser Glu Ile Ser Ser Thr 
    930                 935                 


<210>  2
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICP0 protein

<400>  2

Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro 
1               5                   10                  15      


Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp 
            20                  25                  30          


Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg 
        35                  40                  45              


Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser 
    50                  55                  60                  


Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val 
65                  70                  75                  80  


Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro 
                85                  90                  95      


Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu 
            100                 105                 110         


Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg 
        115                 120                 125             


Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys 
    130                 135                 140                 


Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu 
145                 150                 155                 160 


Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile 
                165                 170                 175     


Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val 
            180                 185                 190         


Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe 
        195                 200                 205             


Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser 
    210                 215                 220                 


Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp 
225                 230                 235                 240 


Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro 
                245                 250                 255     


Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His 
            260                 265                 270         


Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro 
        275                 280                 285             


Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro Arg Gly Ala 
305                 310                 315                 320 


Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val Val Glu Ala 
                325                 330                 335     


Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro 
            340                 345                 350         


Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro 
        355                 360                 365             


Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala 
    370                 375                 380                 


Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg 
385                 390                 395                 400 


Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro 
                405                 410                 415     


Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala 
            420                 425                 430         


Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala 
        435                 440                 445             


Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly 
    450                 455                 460                 


Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala 
465                 470                 475                 480 


Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser Val Glu Gln 
                485                 490                 495     


Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn 
            500                 505                 510         


Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys 
        515                 520                 525             


Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly 
    530                 535                 540                 


Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser 
545                 550                 555                 560 


Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Ala 
                565                 570                 575     


Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly 
            580                 585                 590         


Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly 
        595                 600                 605             


Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys 
    610                 615                 620                 


Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr 
625                 630                 635                 640 


Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro 
                645                 650                 655     


Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met 
            660                 665                 670         


Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly 
        675                 680                 685             


Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg 
    690                 695                 700                 


Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro Pro Glu Tyr 
705                 710                 715                 720 


Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val 
                725                 730                 735     


Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe 
            740                 745                 750         


Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser 
        755                 760                 765             


Thr Arg Asp Glu Gly Lys Gln 
    770                 775 


<210>  3
<211>  3200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRE sequence

<400>  3
cctaccaagt gtacattagg gttccattat ttgcatatcc tgggcaacac tttttctggt       60

gtttttgttg ctattgtttt tatagcaaca aataggttct aataggtata ggctgatatc      120

tcattgtggt tttgatttgg tttggttttt ttccttctga ttagtgatat tggtcatctt      180

catatgcttg ttggacattt gtatatcatc tttgggaaaa tgtctaagtt ctttgcccat      240

ttttatatgc tctctttttt tctatgttac tcctttttta gctgctcttt tttccttttg      300

ttgattctcc ctctgccctc tctttttcag tttctagttg ttctgctttt cctgctaatt      360

ctgcatgtgc ttctcttttc tcctatgctt ctttctgctg tttttcattt ttctttctct      420

gcctgctttt tcagtatcta ttcattttgc ttctgtttct ctttttcaac ttctgttaat      480

tctgtttctt tttctgctga ttccacatag cttctccttt ttgcagctat tttccttctg      540

ttgactctgc cctatttctt cttccacctt ttcagtgtgc tgattttacc tccgcttctc      600

cttgttccca tgcttctcct ttctgcagct attttacctt atgctgactt tcctttattc      660

tggttccctc ttctttcagc atctgctgat gtggccactg ctccttgttc ctgtgcttct      720

gctttctgca gctgatttac ttctgctgac tttgccctgt tctggttccc tcttctttca      780

gcatctgctg atgtggcctc tgcttctcct tgttcctgtg cttcttcttt ctgcagctat      840

tttaccttct gctgactttg ccttgttctg attccctctt tcagtatcat ctgatgtggc      900

ctctgcttct ccttgttcct gtgcttctcc tttctgcagc tatttaacct tctgctgact      960

ttgccttatt ctggttccct cttctttcag catctgctga tgtggcctct gcttctcttt     1020

gttcctgtgc ttctcctttc tgcagctgat ttacttctgc tgactttgcc ctgttctgct     1080

tccgtcttct ttcagcatct gctgatgtgg gctctgcttc tcctttttcc catgtttctc     1140

ctttctgcag cttttttttt tttttctgct gactcttgct tccccacttt tagcatctgc     1200

taatttggtc tctgcttctc ctttttccta tgcttctcat tcctgctgct gttttcactt     1260

ttgctgactc tgccctactt cccccttctt ttagcatctg ttcatggcct ctgcttctcc     1320

tttttcctat gtttctcctt tctgcagctg tttttttcct gctgactctt gcttccccat     1380

tttagcatct gctaatttgg cctctgcttc tcctttttcc tatgcttctc atttctgctg     1440

ctgttttcac gtttgctgac tctgccctac ttccctcttc tttcagcatc tgttcatggc     1500

ctctgcttct cctttttcct atgtttctcc tttctgcagc tgattttttc ctgctgactc     1560

ttgcttcccc attttagcat ctgctaattt ggcctctgct tctccttttt cctatgcttc     1620

tcatttctgc tgctgttttc atgtttgctg actctgccct acttccccct actttcagca     1680

tctgttcatg gcctctgctt ctcctttttc ctatgtttct cctttctgta gctgtttttt     1740

tcctgctgac tcttgcttcc ccattttagc atctgctaat ttggcctctg cttctccttt     1800

ttcctgtgct tctcttttct gctgctgttt tcacttttgc tgtctctgcc ctacttcccc     1860

cttctttcag catctgttca tggcctctgc ttctcctttt tcctatgttt ctcctttctg     1920

tagctgtttt tttcctgctg actcttgctt ccccatttta gcatctgcta atttggtctc     1980

tgcttctcct ttttcctgtg cttctctttt ctgctgctgt tttcactttt gctgtctctg     2040

ccctacttcc cccttctttc agcatctgtt catggcctct gcttctcctt tgtcctatgt     2100

ttgtcctttc tgtagctgtt tttttcctgc tgactcttgc ttccccattt tagcatctgc     2160

taatttggcc tctgcttctc cttttccctg tgcttctctt ttctgctgct gttttcactt     2220

ttgctgtctc tgccctactt cccccttctt tcagcatctg ttcatggcct ctgcttctcc     2280

tttttcctat gtttgtcctt tctgtagctg tttttttcct gctgactctt gcttccccat     2340

tttagcatct gctaatttgg cctctgcttc tcctttttcc tatgcttctc atttctgctg     2400

ctgttttcac gtttgctgac tctaccctac ttcccccttc tttcagcatc tgttcatggc     2460

ctctgcttct cctttttcct atgtttctcc tttctgtagc tgtttttttc ctgctgactc     2520

ttgcttcccc attttagcat ctgctaattt ggcctctgct tctccttttt cctgtgcttc     2580

tcatttctgc tgctgttttc acgtttgctg actctggctc cacatctgct tctcccatct     2640

ttcagcatct actgattctg ctactttttc tgatgatttt gcctctgctt ctccttcttc     2700

ctatgcttct cctttctgaa gctgtttttc cttttgctga ctctacttcc acgctgattc     2760

cccctttttc agcatcttct gattcaggtg cttttttgct gatcctgcct ctgcttttcc     2820

ttttcctacc tctacttttc cttttgttga ttctgcttct ctttctgctg atgctaattt     2880

cctttctact gccgatgttg atcctgctcc ttttgcttct ccttggtctt ctacatttta     2940

atgtgttata ctatttctgg cctcctcgta gtttcacgtt tacatggccc ttaatggcta     3000

ttctattcct ggttgcacca tatgtttgca ctcacaaatg ctctactatc tgtttttcaa     3060

tttctaatta ccctatacac acttccttta aataggaata taatattaaa gtaatggtac     3120

tatgtcatag gcagctggtt aactgatgga ctagctgtta cacagccctt agatgctcac     3180

ttctagaacg gtcaccatgg                                                 3200


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RSAD2 forward primer

<400>  4
caactacaaa tgcggcttct                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RSAD2 reverse primer

<400>  5
atcttctcca taccagcttc c                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL10 forward primer

<400>  6
tctgaatcca gaatcgaagg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL10 reverse primer

<400>  7
ctctgtgtgg tccatccttg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH forward primer

<400>  8
gagtcaacgg atttggtcgt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH reverse primer

<400>  9
gacaagcttc ccgttctcag                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNB1 forward primer

<400>  10
cagcatctgc tggttgaaga                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNB1 reverse primer

<400>  11
cattacctga aggccaagga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MLLT3 forward primer

<400>  12
gagcacagta acatacagca                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MLLT3 reverse primer

<400>  13
ggcaaaatga aaccagcata                                                   20


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  14
gatgaacttt gacatccctg agg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STING sgRNA target site

<400>  15
gcgggccgac cgcatttggg agg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBK1 sgRNA target site

<400>  16
acagtgtata aactcccaca tgg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IKBKE (IKK) sgRNA target site

<400>  17
tgcatcgcga catcaagccg ggg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHUK (IKK) sgRNA target site

<400>  18
tagtttagta gtagaaccca tgg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IKBKB (IKK) sgRNA target site

<400>  19
gccatggagt actgccaagg agg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRF7 sgRNA target site

<400>  20
ccgagctgca cgttcctata cgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRF3 sgRNA target site

<400>  21
gttactgggt aacatggtgt tgg                                               23


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRIM33 sgRNA target site

<400>  22
gttatgaact tcacaaattg gg                                                22


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VMP1 sgRNA target site

<400>  23
gaactgccag tttggcccgg g                                                 21


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBA3  sgRNA target site

<400>  24
ggcctaagga gcagcctttt gg                                                22


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NAE1 sgRNA target site

<400>  25
gaattaaata gcgatgtctc tgg                                               23


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NF1 sgRNA target site

<400>  26
gctggtttcc ttcacgacag g                                                 21


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  USP18 sgRNA target site

<400>  27
ggcacagtca acgcaaatca agg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFIC sgRNA target site

<400>  28
gctgctgggc gagaagcccg agg                                               23


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EFR3A sgRNA target site

<400>  29
gattgctatg gaggcactgg                                                   20


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTPN1 sgRNA target site

<400>  30
gagcagatcg acaagtccgg g                                                 21


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MORC3 sgRNA target site

<400>  31
gctgatactg agataccata tgg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TAF5L sgRNA target site

<400>  32
gctgctcaat gacatccttc tgg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF7 sgRNA target site

<400>  33
ggccatgtgg agctgggacg tgg                                               23


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI4KA sgRNA target site

<400>  34
gggatagcat acttgcaaag g                                                 21


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNAR1 sgRNA target site

<400>  35
gtacattgta taaagaccac agg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNAR2 sgRNA target site

<400>  36
tgagtggaga agcacacacg agg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STAT1 sgRNA target site

<400>  37
caggaggtca tgaaaacgga tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STAT2 sgRNA target site

<400>  38
atcatctcag ccaactgggt agg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFNB1 sgRNA target site

<400>  39
gatgaacttt gacatccctg agg                                               23


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scramble sequence

<400>  40
gctgctccct aacaggacgc                                                   20


<210>  41
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 0nt stagger

<400>  41
acactctttc cctacacgac gctcttccga tctccttgga gaaccacctt gttgg            55


<210>  42
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 1nt stagger

<400>  42
acactctttc cctacacgac gctcttccga tctcccttgg agaaccacct tgttgg           56


<210>  43
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 2nt stagger

<400>  43
acactctttc cctacacgac gctcttccga tctgcccttg gagaaccacc ttgttgg          57


<210>  44
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 3nt stagger

<400>  44
acactctttc cctacacgac gctcttccga tctagccctt ggagaaccac cttgttgg         58


<210>  45
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 4nt stagger

<400>  45
acactctttc cctacacgac gctcttccga tctcaaccct tggagaacca ccttgttgg        59


<210>  46
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 6nt stagger

<400>  46
acactctttc cctacacgac gctcttccga tcttgcaccc cttggagaac caccttgttg       60

g                                                                       61


<210>  47
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 7nt stagger

<400>  47
acactctttc cctacacgac gctcttccga tctacgcaac ccttggagaa ccaccttgtt       60

gg                                                                      62


<210>  48
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320fwd 8nt stagger

<400>  48
acactctttc cctacacgac gctcttccga tctgaagacc cccttggaga accaccttgt       60

tgg                                                                     63


<210>  49
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMCB320rev2

<400>  49
tgactggagt tcagacgtgt gctcttccga tcttcaccac acacggcact tacct            55


<210>  50
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad1

<400>  50
aatgatacgg cgaccaccga gatctacact cgtcggcagc gtcagatgtg                  50


<210>  51
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad2.1

<400>  51
caagcagaag acggcatacg agattcgcct tagtctcgtg ggctcggaga tgt              53


<210>  52
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad2.2

<400>  52
caagcagaag acggcatacg agatctagta cggtctcgtg ggctcggaga tgt              53


<210>  53
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad2.3

<400>  53
caagcagaag acggcatacg agatttctgc ctgtctcgtg ggctcggaga tgt              53


<210>  54
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad2.4

<400>  54
caagcagaag acggcatacg agatgctcag gagtctcgtg ggctcggaga tgt              53


<210>  55
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad2.5

<400>  55
caagcagaag acggcatacg agataggagt ccgtctcgtg ggctcggaga tgt              53


<210>  56
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad2.6

<400>  56
caagcagaag acggcatacg agatcatgcc tagtctcgtg ggctcggaga tgt              53


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MORC3 crRNA

<400>  57
gctgatactg agataccata tgg                                               23


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scramble crRNA

<400>  58
gctgctccct aacaggacgc                                                   20


<210>  59
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT MRE locus sequence

<400>  59
actgttttat atagtggtca catcatttta taatcctacc aagtgtacat tagggttcca       60

tt                                                                      62


<210>  60
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT MRE locus sequence

<400>  60
ccatggcaca ggctgggaag cagaaaaact agagactc                               38


<210>  61
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRE locus sequence

<400>  61
actgttttat atagtggtca catcatttta taatcctacc taccccccca tggcacaggc       60

tgggaagcag aaaaactaga gactc                                             85


<210>  62
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRE locus sequence

<400>  62
actgttttat atagtggtca catcatttta taatcctacc accatggcac aggctgggaa       60

gcagaaaaac tagagactc                                                    79


