                         SEQUENCE LISTING

<110>  Wake Forest University Health Sciences
 
<120>  ENGINEERED EXTRACELLULAR VESICLES AND THEIR USES  


<130>  095199-1293190

<150>  US  63/148,872
<151>  2021-02-12

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
atggcttcta actttactca gttcgttctc gtcgacaatg gcggaactgg cgacgtgact       60

gtcgccccaa gcaacttcgc taacgggatc gctgaatgga tcagctctaa ctcgcgttca      120

caggcttaca aagtaacctg tagcgttcgt cagagctctg cgcagaatcg caaatacacc      180

atcaaagtcg aggtgcctaa aggcgcctgg cgttcgtact taaatatgga actaaccatt      240

ccaattttcg ccacgaattc cgactgcgag cttattgtta aggcaatgca aggtctccta      300

aaagatggaa acccgattcc ctcagcaatc gcagcaaact ccggcatcta c               351


<210>  2
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr 
        115         


<210>  3
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
tccaaaacaa tagtcctctc cgtaggggag gcaacacgga ctttgaccga aatccagtca       60

accgctgacc gacaaatctt tgaagagaaa gtagggcctc ttgtgggccg actgcgcttg      120

actgcaagct tgcgacaaaa cggcgcaaag actgcctata gggtcaacct taaactcgac      180

caagccgacg tggtcgatag cggtctccct aaggttcggt atacgcaggt ctggagtcat      240

gacgtaacaa tcgtagcaaa cagcacagaa gcctcccgaa aaagcctcta cgatctgacg      300

aaatccttgg tggctacgtc acaggtggaa gacctcgttg tcaaccttgt acctctgggt      360

cga                                                                    363


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu Thr 
1               5                   10                  15      


Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val Gly 
            20                  25                  30          


Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn Gly 
        35                  40                  45              


Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp Val 
    50                  55                  60                  


Val Asp Ser Gly Leu Pro Lys Val Arg Tyr Thr Gln Val Trp Ser His 
65                  70                  75                  80  


Asp Val Thr Ile Val Ala Asn Ser Thr Glu Ala Ser Arg Lys Ser Leu 
                85                  90                  95      


Tyr Asp Leu Thr Lys Ser Leu Val Ala Thr Ser Gln Val Glu Asp Leu 
            100                 105                 110         


Val Val Asn Leu Val Pro Leu Gly Arg 
        115                 120     


<210>  5
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
atggatgcac aaacacgccg ccgcgaacgt cgcgcagaga aacaggctca atggaaagca       60

gcaaat                                                                  66


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn 
            20          


<210>  7
<211>  193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
atgaaatcaa ttcgctgtaa aaactgcaac aaactgttat ttaaggcgga ttcctttgat       60

cacattgaaa tcaggtgtcc gcgttgcaaa cgtcacatca taatgctgaa tgcctgcgag      120

catcccacgg agaaacattg tgggaaaaga gaaaaaatca cgcattctga cgaaaccgtg      180

cgttattgag tat                                                         193


<210>  8
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr 
    50                  55                  60          


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
acagaggaca cccag                                                        15


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
acatgaggat cacccatgt                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
ggagcagacg aaggcgcgcc c                                                 21


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
ggagcagacg atatggcgtc gctcc                                             25


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
gggcccgaag aagggccc                                                     18


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
gggccctgaa gaagggccc                                                    19


<210>  15
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
cgaagccgcg agcac                                                        15


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
ctgaatgcct gcgagcat                                                     18


<210>  17
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac       60

taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt      120

tattttcatt gc                                                          132


<210>  18
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
gccgccgcgc caacaaaagg ccgcccaagc caacacaaac gggggaaaga agggccgagc       60

acggacgcca aaaaaaacaa cagc                                              84


<210>  19
<211>  5403
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
atgaaacgga cagccgacgg aagcgagttc gagtcaccaa agaagaagcg gaaagtctct       60

gaagtcgagt ttagccacga gtattggatg aggcacgcac tgaccctggc aaagcgagca      120

tgggatgaaa gagaagtccc cgtgggcgcc gtgctggtgc acaacaatag agtgatcgga      180

gagggatgga acaggccaat cggccgccac gaccctaccg cacacgcaga gatcatggca      240

ctgaggcagg gaggcctggt catgcagaat taccgcctga tcgatgccac cctgtatgtg      300

acactggagc catgcgtgat gtgcgcagga gcaatgatcc acagcaggat cggaagagtg      360

gtgttcggag cacgggacgc caagaccggc gcagcaggct ccctgatgga tgtgctgcac      420

caccccggca tgaaccaccg ggtggagatc acagagggaa tcctggcaga cgagtgcgcc      480

gccctgctga gcgatttctt tagaatgcgg agacaggaga tcaaggccca gaagaaggca      540

cagagctcca ccgactctgg aggatctagc ggaggatcct ctggaagcga gacaccaggc      600

acaagcgagt ccgccacacc agagagctcc ggcggctcct ccggaggatc ctctgaggtg      660

gagttttccc acgagtactg gatgagacat gccctgaccc tggccaagag ggcacgcgat      720

gagagggagg tgcctgtggg agccgtgctg gtgctgaaca atagagtgat cggcgagggc      780

tggaacagag ccatcggcct gcacgaccca acagcccatg ccgaaattat ggccctgaga      840

cagggcggcc tggtcatgca gaactacaga ctgattgacg ccaccctgta cgtgacattc      900

gagccttgcg tgatgtgcgc cggcgccatg atccactcta ggatcggccg cgtggtgttt      960

ggcgtgagga acgcaaaaac cggcgccgca ggctccctga tggacgtgct gcactacccc     1020

ggcatgaatc accgcgtcga aattaccgag ggaatcctgg cagatgaatg tgccgccctg     1080

ctgtgctatt tctttcggat gcctagacag gtgttcaatg ctcagaagaa ggcccagagc     1140

tccaccgact ccggaggatc tagcggaggc tcctctggct ctgagacacc tggcacaagc     1200

gagagcgcaa cacctgaaag cagcgggggc agcagcgggg ggtcagacaa gaagtacagc     1260

atcggcctgg ccatcggcac caactctgtg ggctgggccg tgatcaccga cgagtacaag     1320

gtgcccagca agaaattcaa ggtgctgggc aacaccgacc ggcacagcat caagaagaac     1380

ctgatcggag ccctgctgtt cgacagcggc gaaacagccg aggccacccg gctgaagaga     1440

accgccagaa gaagatacac cagacggaag aaccggatct gctatctgca agagatcttc     1500

agcaacgaga tggccaaggt ggacgacagc ttcttccaca gactggaaga gtccttcctg     1560

gtggaagagg ataagaagca cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg     1620

gcctaccacg agaagtaccc caccatctac cacctgagaa agaaactggt ggacagcacc     1680

gacaaggccg acctgcggct gatctatctg gccctggccc acatgatcaa gttccggggc     1740

cacttcctga tcgagggcga cctgaacccc gacaacagcg acgtggacaa gctgttcatc     1800

cagctggtgc agacctacaa ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg     1860

gacgccaagg ccatcctgtc tgccagactg agcaagagca gacggctgga aaatctgatc     1920

gcccagctgc ccggcgagaa gaagaatggc ctgttcggaa acctgattgc cctgagcctg     1980

ggcctgaccc ccaacttcaa gagcaacttc gacctggccg aggatgccaa actgcagctg     2040

agcaaggaca cctacgacga cgacctggac aacctgctgg cccagatcgg cgaccagtac     2100

gccgacctgt ttctggccgc caagaacctg tccgacgcca tcctgctgag cgacatcctg     2160

agagtgaaca ccgagatcac caaggccccc ctgagcgcct ctatgatcaa gagatacgac     2220

gagcaccacc aggacctgac cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag     2280

tacaaagaga ttttcttcga ccagagcaag aacggctacg ccggctacat tgacggcgga     2340

gccagccagg aagagttcta caagttcatc aagcccatcc tggaaaagat ggacggcacc     2400

gaggaactgc tcgtgaagct gaacagagag gacctgctgc ggaagcagcg gaccttcgac     2460

aacggcagca tcccccacca gatccacctg ggagagctgc acgccattct gcggcggcag     2520

gaagattttt acccattcct gaaggacaac cgggaaaaga tcgagaagat cctgaccttc     2580

cgcatcccct actacgtggg ccctctggcc aggggaaaca gcagattcgc ctggatgacc     2640

agaaagagcg aggaaaccat caccccctgg aacttcgagg aagtggtgga caagggcgct     2700

tccgcccaga gcttcatcga gcggatgacc aacttcgata agaacctgcc caacgagaag     2760

gtgctgccca agcacagcct gctgtacgag tacttcaccg tgtataacga gctgaccaaa     2820

gtgaaatacg tgaccgaggg aatgagaaag cccgccttcc tgagcggcga gcagaaaaag     2880

gccatcgtgg acctgctgtt caagaccaac cggaaagtga ccgtgaagca gctgaaagag     2940

gactacttca agaaaatcga gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg     3000

ttcaacgcct ccctgggcac ataccacgat ctgctgaaaa ttatcaagga caaggacttc     3060

ctggacaatg aggaaaacga ggacattctg gaagatatcg tgctgaccct gacactgttt     3120

gaggacagag agatgatcga ggaacggctg aaaacctatg cccacctgtt cgacgacaaa     3180

gtgatgaagc agctgaagcg gcggagatac accggctggg gcaggctgag ccggaagctg     3240

atcaacggca tccgggacaa gcagtccggc aagacaatcc tggatttcct gaagtccgac     3300

ggcttcgcca acagaaactt catgcagctg atccacgacg acagcctgac ctttaaagag     3360

gacatccaga aagcccaggt gtccggccag ggcgatagcc tgcacgagca cattgccaat     3420

ctggccggca gccccgccat taagaagggc atcctgcaga cagtgaaggt ggtggacgag     3480

ctcgtgaaag tgatgggccg gcacaagccc gagaacatcg tgatcgaaat ggccagagag     3540

aaccagacca cccagaaggg acagaagaac agccgcgaga gaatgaagcg gatcgaagag     3600

ggcatcaaag agctgggcag ccagatcctg aaagaacacc ccgtggaaaa cacccagctg     3660

cagaacgaga agctgtacct gtactacctg cagaatgggc gggatatgta cgtggaccag     3720

gaactggaca tcaaccggct gtccgactac gatgtggacc atatcgtgcc tcagagcttt     3780

ctgaaggacg actccatcga caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag     3840

agcgacaacg tgccctccga agaggtcgtg aagaagatga agaactactg gcggcagctg     3900

ctgaacgcca agctgattac ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc     3960

ggcctgagcg aactggataa ggccggcttc atcaagagac agctggtgga aacccggcag     4020

atcacaaagc acgtggcaca gatcctggac tcccggatga acactaagta cgacgagaat     4080

gacaagctga tccgggaagt gaaagtgatc accctgaagt ccaagctggt gtccgatttc     4140

cggaaggatt tccagtttta caaagtgcgc gagatcaaca actaccacca cgcccacgac     4200

gcctacctga acgccgtcgt gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc     4260

gagttcgtgt acggcgacta caaggtgtac gacgtgcgga agatgatcgc caagagcgag     4320

caggaaatcg gcaaggctac cgccaagtac ttcttctaca gcaacatcat gaactttttc     4380

aagaccgaga ttaccctggc caacggcgag atccggaagc ggcctctgat cgagacaaac     4440

ggcgaaaccg gggagatcgt gtgggataag ggccgggatt ttgccaccgt gcggaaagtg     4500

ctgagcatgc cccaagtgaa tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc     4560

aaagagtcta tcctgcccaa gaggaacagc gataagctga tcgccagaaa gaaggactgg     4620

gaccctaaga agtacggcgg cttcgacagc cccaccgtgg cctattctgt gctggtggtg     4680

gccaaagtgg aaaagggcaa gtccaagaaa ctgaagagtg tgaaagagct gctggggatc     4740

accatcatgg aaagaagcag cttcgagaag aatcccatcg actttctgga agccaagggc     4800

tacaaagaag tgaaaaagga cctgatcatc aagctgccta agtactccct gttcgagctg     4860

gaaaacggcc ggaagagaat gctggcctct gccggcgaac tgcagaaggg aaacgaactg     4920

gccctgccct ccaaatatgt gaacttcctg tacctggcca gccactatga gaagctgaag     4980

ggctcccccg aggataatga gcagaaacag ctgtttgtgg aacagcacaa gcactacctg     5040

gacgagatca tcgagcagat cagcgagttc tccaagagag tgatcctggc cgacgctaat     5100

ctggacaaag tgctgtccgc ctacaacaag caccgggata agcccatcag agagcaggcc     5160

gagaatatca tccacctgtt taccctgacc aatctgggag cccctgccgc cttcaagtac     5220

tttgacacca ccatcgaccg gaagaggtac accagcacca aagaggtgct ggacgccacc     5280

ctgatccacc agagcatcac cggcctgtac gagacacgga tcgacctgtc tcagctggga     5340

ggcgacaaaa ggccggcggc cacgaaaaag gccggccagg caaaaaagaa aaagggatcc     5400

taa                                                                   5403


<210>  20
<211>  1800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His 
            20                  25                  30          


Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val 
        35                  40                  45              


Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn 
    50                  55                  60                  


Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala 
65                  70                  75                  80  


Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala 
                85                  90                  95      


Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met 
            100                 105                 110         


Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys 
        115                 120                 125             


Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met 
    130                 135                 140                 


Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala 
145                 150                 155                 160 


Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala 
                165                 170                 175     


Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly 
            180                 185                 190         


Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
        195                 200                 205             


Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His 
    210                 215                 220                 


Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp 
225                 230                 235                 240 


Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val 
                245                 250                 255     


Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala 
            260                 265                 270         


His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn 
        275                 280                 285             


Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val 
    290                 295                 300                 


Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe 
305                 310                 315                 320 


Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val 
                325                 330                 335     


Leu His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile 
            340                 345                 350         


Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro 
        355                 360                 365             


Arg Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser 
    370                 375                 380                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
385                 390                 395                 400 


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp 
                405                 410                 415     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            420                 425                 430         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        435                 440                 445             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    450                 455                 460                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
465                 470                 475                 480 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                485                 490                 495     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            500                 505                 510         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        515                 520                 525             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    530                 535                 540                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
545                 550                 555                 560 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                565                 570                 575     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            580                 585                 590         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        595                 600                 605             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    610                 615                 620                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
625                 630                 635                 640 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                645                 650                 655     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            660                 665                 670         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        675                 680                 685             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    690                 695                 700                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                725                 730                 735     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            740                 745                 750         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        755                 760                 765             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    770                 775                 780                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
785                 790                 795                 800 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                805                 810                 815     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            820                 825                 830         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        835                 840                 845             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    850                 855                 860                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
865                 870                 875                 880 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                885                 890                 895     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            900                 905                 910         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        915                 920                 925             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    930                 935                 940                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
945                 950                 955                 960 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                965                 970                 975     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            980                 985                 990         


Glu Ile Ser Gly Val Glu Asp Arg  Phe Asn Ala Ser Leu  Gly Thr Tyr 
        995                 1000                 1005             


His Asp  Leu Leu Lys Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn 
    1010                 1015                 1020             


Glu Glu  Asn Glu Asp Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr 
    1025                 1030                 1035             


Leu Phe  Glu Asp Arg Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr 
    1040                 1045                 1050             


Ala His  Leu Phe Asp Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg 
    1055                 1060                 1065             


Arg Tyr  Thr Gly Trp Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly 
    1070                 1075                 1080             


Ile Arg  Asp Lys Gln Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys 
    1085                 1090                 1095             


Ser Asp  Gly Phe Ala Asn Arg  Asn Phe Met Gln Leu  Ile His Asp 
    1100                 1105                 1110             


Asp Ser  Leu Thr Phe Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser 
    1115                 1120                 1125             


Gly Gln  Gly Asp Ser Leu His  Glu His Ile Ala Asn  Leu Ala Gly 
    1130                 1135                 1140             


Ser Pro  Ala Ile Lys Lys Gly  Ile Leu Gln Thr Val  Lys Val Val 
    1145                 1150                 1155             


Asp Glu  Leu Val Lys Val Met  Gly Arg His Lys Pro  Glu Asn Ile 
    1160                 1165                 1170             


Val Ile  Glu Met Ala Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln 
    1175                 1180                 1185             


Lys Asn  Ser Arg Glu Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys 
    1190                 1195                 1200             


Glu Leu  Gly Ser Gln Ile Leu  Lys Glu His Pro Val  Glu Asn Thr 
    1205                 1210                 1215             


Gln Leu  Gln Asn Glu Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly 
    1220                 1225                 1230             


Arg Asp  Met Tyr Val Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser 
    1235                 1240                 1245             


Asp Tyr  Asp Val Asp His Ile  Val Pro Gln Ser Phe  Leu Lys Asp 
    1250                 1255                 1260             


Asp Ser  Ile Asp Asn Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg 
    1265                 1270                 1275             


Gly Lys  Ser Asp Asn Val Pro  Ser Glu Glu Val Val  Lys Lys Met 
    1280                 1285                 1290             


Lys Asn  Tyr Trp Arg Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln 
    1295                 1300                 1305             


Arg Lys  Phe Asp Asn Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser 
    1310                 1315                 1320             


Glu Leu  Asp Lys Ala Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr 
    1325                 1330                 1335             


Arg Gln  Ile Thr Lys His Val  Ala Gln Ile Leu Asp  Ser Arg Met 
    1340                 1345                 1350             


Asn Thr  Lys Tyr Asp Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys 
    1355                 1360                 1365             


Val Ile  Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
    1370                 1375                 1380             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1385                 1390                 1395             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1400                 1405                 1410             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1415                 1420                 1425             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1430                 1435                 1440             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1445                 1450                 1455             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1460                 1465                 1470             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1475                 1480                 1485             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1490                 1495                 1500             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1505                 1510                 1515             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1520                 1525                 1530             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1535                 1540                 1545             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1550                 1555                 1560             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1565                 1570                 1575             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1580                 1585                 1590             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1595                 1600                 1605             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1610                 1615                 1620             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1625                 1630                 1635             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1640                 1645                 1650             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1655                 1660                 1665             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1670                 1675                 1680             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1685                 1690                 1695             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1700                 1705                 1710             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1715                 1720                 1725             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1730                 1735                 1740             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1745                 1750                 1755             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1760                 1765                 1770             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1775                 1780                 1785             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Gly Ser  
    1790                 1795                 1800 


<210>  21
<211>  4278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
atggactata aggaccacga cggagactac aaggatcatg atattgatta caaagacgat       60

gacgataaga tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc      120

gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc      180

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      240

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      300

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      360

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      420

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      480

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      540

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      600

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      660

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      720

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      780

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      840

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      900

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      960

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     1020

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     1080

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1140

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1200

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1260

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1320

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1380

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1440

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1500

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1560

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1620

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1680

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1740

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1800

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1860

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1920

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1980

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     2040

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     2100

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2160

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2220

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2280

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2340

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2400

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2460

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2520

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2580

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2640

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2700

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2760

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2820

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2880

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2940

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     3000

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     3060

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3120

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3180

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3240

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3300

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3360

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3420

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3480

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3540

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3600

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3660

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3720

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3780

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3840

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3900

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3960

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     4020

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     4080

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4140

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4200

ctgtctcagc tgggaggcga caaaaggccg gcggccacga aaaaggccgg ccaggcaaaa     4260

aagaaaaagg gatcctaa                                                   4278


<210>  22
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  23
<211>  4272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
atggactata aggaccacga cggagactac aaggatcatg atattgatta caaagacgat       60

gacgataaga tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc      120

gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc      180

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      240

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      300

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      360

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      420

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      480

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      540

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      600

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      660

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      720

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      780

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      840

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      900

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      960

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     1020

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     1080

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1140

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1200

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1260

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1320

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1380

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1440

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1500

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1560

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1620

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1680

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1740

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1800

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1860

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1920

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1980

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     2040

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     2100

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2160

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2220

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2280

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2340

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2400

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2460

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2520

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2580

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2640

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2700

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2760

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2820

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2880

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2940

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     3000

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     3060

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3120

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3180

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3240

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3300

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3360

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3420

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3480

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3540

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3600

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3660

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3720

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3780

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3840

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3900

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3960

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     4020

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     4080

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4140

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4200

ctgtctcagc tgggaggcga caaaaggccg gcggccacga aaaaggccgg ccaggcaaaa     4260

aagaaaaagt aa                                                         4272


<210>  24
<211>  1423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
        995                 1000                 1005             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1010                 1015                 1020             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1040                 1045                 1050             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1055                 1060                 1065             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1070                 1075                 1080             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1085                 1090                 1095             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1100                 1105                 1110             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1115                 1120                 1125             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1130                 1135                 1140             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1160                 1165                 1170             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1175                 1180                 1185             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1190                 1195                 1200             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1205                 1210                 1215             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1220                 1225                 1230             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1250                 1255                 1260             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1280                 1285                 1290             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1295                 1300                 1305             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1310                 1315                 1320             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1325                 1330                 1335             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1340                 1345                 1350             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1355                 1360                 1365             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1370                 1375                 1380             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1385                 1390                 1395             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1400                 1405                 1410             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1415                 1420             


<210>  25
<211>  3345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc caagcggaac       60

tacatcctgg gcctggacat cggcatcacc agcgtgggct acggcatcat cgactacgag      120

acacgggacg tgatcgatgc cggcgtgcgg ctgttcaaag aggccaacgt ggaaaacaac      180

gagggcaggc ggagcaagag aggcgccaga aggctgaagc ggcggaggcg gcatagaatc      240

cagagagtga agaagctgct gttcgactac aacctgctga ccgaccacag cgagctgagc      300

ggcatcaacc cctacgaggc cagagtgaag ggcctgagcc agaagctgag cgaggaagag      360

ttctctgccg ccctgctgca cctggccaag agaagaggcg tgcacaacgt gaacgaggtg      420

gaagaggaca ccggcaacga gctgtccacc aaagagcaga tcagccggaa cagcaaggcc      480

ctggaagaga aatacgtggc cgaactgcag ctggaacggc tgaagaaaga cggcgaagtg      540

cggggcagca tcaacagatt caagaccagc gactacgtga aagaagccaa acagctgctg      600

aaggtgcaga aggcctacca ccagctggac cagagcttca tcgacaccta catcgacctg      660

ctggaaaccc ggcggaccta ctatgaggga cctggcgagg gcagcccctt cggctggaag      720

gacatcaaag aatggtacga gatgctgatg ggccactgca cctacttccc cgaggaactg      780

cggagcgtga agtacgccta caacgccgac ctgtacaacg ccctgaacga cctgaacaat      840

ctcgtgatca ccagggacga gaacgagaag ctggaatatt acgagaagtt ccagatcatc      900

gagaacgtgt tcaagcagaa gaagaagccc accctgaagc agatcgccaa agaaatcctc      960

gtgaacgaag aggatattaa gggctacaga gtgaccagca ccggcaagcc cgagttcacc     1020

aacctgaagg tgtaccacga catcaaggac attaccgccc ggaaagagat tattgagaac     1080

gccgagctgc tggatcagat tgccaagatc ctgaccatct accagagcag cgaggacatc     1140

caggaagaac tgaccaatct gaactccgag ctgacccagg aagagatcga gcagatctct     1200

aatctgaagg gctataccgg cacccacaac ctgagcctga aggccatcaa cctgatcctg     1260

gacgagctgt ggcacaccaa cgacaaccag atcgctatct tcaaccggct gaagctggtg     1320

cccaagaagg tggacctgtc ccagcagaaa gagatcccca ccaccctggt ggacgacttc     1380

atcctgagcc ccgtcgtgaa gagaagcttc atccagagca tcaaagtgat caacgccatc     1440

atcaagaagt acggcctgcc caacgacatc attatcgagc tggcccgcga gaagaactcc     1500

aaggacgccc agaaaatgat caacgagatg cagaagcgga accggcagac caacgagcgg     1560

atcgaggaaa tcatccggac caccggcaaa gagaacgcca agtacctgat cgagaagatc     1620

aagctgcacg acatgcagga aggcaagtgc ctgtacagcc tggaagccat ccctctggaa     1680

gatctgctga acaacccctt caactatgag gtggaccaca tcatccccag aagcgtgtcc     1740

ttcgacaaca gcttcaacaa caaggtgctc gtgaagcagg aagaaaacag caagaagggc     1800

aaccggaccc cattccagta cctgagcagc agcgacagca agatcagcta cgaaaccttc     1860

aagaagcaca tcctgaatct ggccaagggc aagggcagaa tcagcaagac caagaaagag     1920

tatctgctgg aagaacggga catcaacagg ttctccgtgc agaaagactt catcaaccgg     1980

aacctggtgg ataccagata cgccaccaga ggcctgatga acctgctgcg gagctacttc     2040

agagtgaaca acctggacgt gaaagtgaag tccatcaatg gcggcttcac cagctttctg     2100

cggcggaagt ggaagtttaa gaaagagcgg aacaaggggt acaagcacca cgccgaggac     2160

gccctgatca ttgccaacgc cgatttcatc ttcaaagagt ggaagaaact ggacaaggcc     2220

aaaaaagtga tggaaaacca gatgttcgag gaaaagcagg ccgagagcat gcccgagatc     2280

gaaaccgagc aggagtacaa agagatcttc atcacccccc accagatcaa gcacattaag     2340

gacttcaagg actacaagta cagccaccgg gtggacaaga agcctaatag agagctgatt     2400

aacgacaccc tgtactccac ccggaaggac gacaagggca acaccctgat cgtgaacaat     2460

ctgaacggcc tgtacgacaa ggacaatgac aagctgaaaa agctgatcaa caagagcccc     2520

gaaaagctgc tgatgtacca ccacgacccc cagacctacc agaaactgaa gctgattatg     2580

gaacagtacg gcgacgagaa gaatcccctg tacaagtact acgaggaaac cgggaactac     2640

ctgaccaagt actccaaaaa ggacaacggc cccgtgatca agaagattaa gtattacggc     2700

aacaaactga acgcccatct ggacatcacc gacgactacc ccaacagcag aaacaaggtc     2760

gtgaagctgt ccctgaagcc ctacagattc gacgtgtacc tggacaatgg cgtgtacaag     2820

ttcgtgaccg tgaagaatct ggatgtgatc aaaaaagaaa actactacga agtgaatagc     2880

aagtgctatg aggaagctaa gaagctgaag aagatcagca accaggccga gtttatcgcc     2940

tccttctaca acaacgatct gatcaagatc aacggcgagc tgtatagagt gatcggcgtg     3000

aacaacgacc tgctgaaccg gatcgaagtg aacatgatcg acatcaccta ccgcgagtac     3060

ctggaaaaca tgaacgacaa gaggcccccc aggatcatta agacaatcgc ctccaagacc     3120

cagagcatta agaagtacag cacagacatt ctgggcaacc tgtatgaagt gaaatctaag     3180

aagcaccctc agatcatcaa aaagggcaaa aggccggcgg ccacgaaaaa ggccggccag     3240

gcaaaaaaga aaaagggatc ctacccatac gatgttccag attacgctta cccatacgat     3300

gttccagatt acgcttaccc atacgatgtt ccagattacg cttaa                     3345


<210>  26
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
            20                  25                  30          


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
        35                  40                  45              


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
    50                  55                  60                  


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
65                  70                  75                  80  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
                85                  90                  95      


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
            100                 105                 110         


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
        115                 120                 125             


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
    130                 135                 140                 


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
145                 150                 155                 160 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
                165                 170                 175     


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
            180                 185                 190         


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
        195                 200                 205             


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
    210                 215                 220                 


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
225                 230                 235                 240 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
                245                 250                 255     


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
            260                 265                 270         


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
        275                 280                 285             


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
    290                 295                 300                 


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
305                 310                 315                 320 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
                325                 330                 335     


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
            340                 345                 350         


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
        355                 360                 365             


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
    370                 375                 380                 


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
385                 390                 395                 400 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
                405                 410                 415     


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
            420                 425                 430         


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
        435                 440                 445             


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
    450                 455                 460                 


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
                485                 490                 495     


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
            500                 505                 510         


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
        515                 520                 525             


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
    530                 535                 540                 


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
                565                 570                 575     


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
            580                 585                 590         


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
        595                 600                 605             


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
    610                 615                 620                 


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
625                 630                 635                 640 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
                645                 650                 655     


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
            660                 665                 670         


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
        675                 680                 685             


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
    690                 695                 700                 


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
705                 710                 715                 720 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
                725                 730                 735     


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
            740                 745                 750         


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
        755                 760                 765             


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
    770                 775                 780                 


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
785                 790                 795                 800 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
                805                 810                 815     


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
            820                 825                 830         


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
        835                 840                 845             


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
    850                 855                 860                 


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
865                 870                 875                 880 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
                885                 890                 895     


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
            900                 905                 910         


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
        915                 920                 925             


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
    930                 935                 940                 


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
945                 950                 955                 960 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
                965                 970                 975     


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
            980                 985                 990         


Glu Leu Tyr Arg Val Ile Gly Val  Asn Asn Asp Leu Leu  Asn Arg Ile 
        995                 1000                 1005             


Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
    1010                 1015                 1020             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1025                 1030                 1035             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1040                 1045                 1050             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1055                 1060                 1065             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1070                 1075                 1080             


Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1085                 1090                 1095             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1100                 1105                 1110             


Ala 
    


<210>  27
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27
gcgcttgctc ttcattccct gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  28
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28
gtaacggcag acttctcctc gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  29
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29
actgttgcct ccggttctga gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  30
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30
gaggacaagt cgtacaatgg gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  31
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31
ccattgttca atatcgtccg gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  32
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32
agccccagca agagcacaag gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  33
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33
gatgagataa tgatgagtca gtttgagagc tagaaatagc aagttcaaat aaggctagtc       60

cgttatcaac ttggctgaat gcctgcgagc atcccaccca agtggcaccg agtcggtgc       119


<210>  34
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34
tatgtggctt taccaaggtc cgtttaagta ctctgctgaa tgcctgcgag catcccacca       60

gaatctactt aaacaaggca aaatgccgtg tttatctcgt caacttgttg gcgagat         117


<210>  35
<211>  116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35
acacagacag actacaccca gtttaagtac tctgctgaat gcctgcgagc atcccaccag       60

aatctactta aacaaggcaa aatgccgtgt ttatctcgtc aacttgttgg cgagat          116


<210>  36
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  37
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37
ggtttagtga accgtcagat ccgctag                                           27


<210>  38
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38
ggcggtcaca actccggagg tggaggtgga cagagcccag gcccggcagc c                51


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Gly Gly His Asn Ser Gly Gly Gly Gly Gly Gln Ser Pro Gly Pro Ala 
1               5                   10                  15      


Ala 
    


<210>  40
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40
tccggtggag gtggatccat ggcttctaac tttactcagt tcgttctcgt cgacaatggc       60

ggaactggcg acgtg                                                        75


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Ser Gly Gly Gly Gly Ser Met Ala Ser Asn Phe Thr Gln Phe Val Leu 
1               5                   10                  15      


Val Asp Asn Gly Gly Thr Gly Asp Val 
            20                  25  


<210>  42
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42
atggcggtgg aaggaggaat gaaatgtgtg aagttcttgc tctacgtcct cctgctggcc       60

ttttgcgcct gtgcagtggg actgattgcc gtgggtgtcg gggcacagct tgtcctgagt      120

cagaccataa tccagggggc tacccctggc tctctgttgc cagtggtcat catcgcagtg      180

ggtgtcttcc tcttcctggt ggcttttgtg ggctgctgcg gggcctgcaa ggagaactat      240

tgtcttatga tcacgtttgc catctttctg tctcttatca tgttggtgga ggtggccgca      300

gccattgctg gctatgtgtt tagagataag gtgatgtcag agtttaataa caacttccgg      360

cagcagatgg agaattaccc gaaaaataac cacactgctt cgatcctgga caggatgcag      420

gcagatttta agtgctgtgg ggctgctaac tacacagatt gggagaaaat cccttccatg      480

tcgaagaacc gagtccccga ctcctgctgc attaatgtta ctgtgggctg tgggattaat      540

ttcaacgaga aggcgatcca taaggagggc tgtgtggaga agattggggg ctggctgagg      600

aaaaatgtgc tggtggtagc tgcagcagcc cttggaattg cttttgtcga ggttttggga      660

attgtctttg cctgctgcct cgtgaagagt atcagaagtg gctacgaggt gatgtag         717


<210>  43
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  44
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagccat acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacagtc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  45
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  46
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagccacc      540

atgaaatcaa ttcgctgtaa aaactgcaac aaactgttat ttaaggcgga ttcctttgat      600

cacattgaaa tcaggtgtcc gcgttgcaaa cgtcacatca taatgctcaa cgcttgtgaa      660

caccctacgg agaaacattg tgggaaaaga gaaaaaatca cgcattctga cgaaaccgtg      720

cgttatggcg gtcacaactc cggaggtgga ggtggacaga gcccaggccc ggcagccatg      780

gcggtggaag gaggaatgaa atgtgtgaag ttcttgctct acgtcctcct gctggccttt      840

tgcgcctgtg cagtgggact gattgccgtg ggtgtcgggg cacagcttgt cctgagtcag      900

accataatcc agggggctac ccctggctct ctgttgccag tggtcatcat cgcagtgggt      960

gtcttcctct tcctggtggc ttttgtgggc tgctgcgggg cctgcaagga gaactattgt     1020

cttatgatca cgtttgccat ctttctgtct cttatcatgt tggtggaggt ggccgcagcc     1080

attgctggct atgtgtttag agataaggtg atgtcagagt ttaataacaa cttccggcag     1140

cagatggaga attacccgaa aaataaccac actgcttcga tcctggacag gatgcaggca     1200

gattttaagt gctgtggggc tgctaactac acagattggg agaaaatccc ttccatgtcg     1260

aagaaccgag tccccgactc ctgctgcatt aatgttactg tgggctgtgg gattaatttc     1320

aacgagaagg cgatccataa ggagggctgt gtggagaaga ttgggggctg gctgaggaaa     1380

aatgtgctgg tggtagctgc agcagccctt ggaattgctt ttgtcgaggt tttgggaatt     1440

gtctttgcct gctgcctcgt gaagagtatc agaagtggct acgaggtgat gtag           1494


<210>  47
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr Gly Gly 
    50                  55                  60                  


His Asn Ser Gly Gly Gly Gly Gly Gln Ser Pro Gly Pro Ala Ala Met 
65                  70                  75                  80  


Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu 
                85                  90                  95      


Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val 
            100                 105                 110         


Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro 
        115                 120                 125             


Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe 
    130                 135                 140                 


Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys 
145                 150                 155                 160 


Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu 
                165                 170                 175     


Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser 
            180                 185                 190         


Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn 
        195                 200                 205             


Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys 
    210                 215                 220                 


Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser 
225                 230                 235                 240 


Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys 
                245                 250                 255     


Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu 
            260                 265                 270         


Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala 
        275                 280                 285             


Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys 
    290                 295                 300                 


Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
305                 310                 315         


<210>  48
<211>  1646
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc      600

agatccgcta gtcgagctca agcttcgaat tctgcagtcg acggtaccag agcccaggcc      660

cggcagccat ggcggtggaa ggaggaatga aatgtgtgaa gttcttgctc tacgtcctcc      720

tgctggcctt ttgcgcctgt gcagtgggac tgattgccgt gggtgtcggg gcacagcttg      780

tcctgagtca gaccataatc cagggggcta cccctggctc tctgttgcca gtggtcatca      840

tcgcagtggg tgtcttcctc ttcctggtgg cttttgtggg ctgctgcggg gcctgcaagg      900

agaactattg tcttatgatc acgtttgcca tctttctgtc tcttatcatg ttggtggagg      960

tggccgcagc cattgctggc tatgtgttta gagataaggt gatgtcagag tttaataaca     1020

acttccggca gcagatggag aattacccga aaaataacca cactgcttcg atcctggaca     1080

ggatgcaggc agattttaag tgctgtgggg ctgctaacta cacagattgg gagaaaatcc     1140

cttccatgtc gaagaaccga gtccccgact cctgctgcat taatgttact gtgggctgtg     1200

ggattaattt caacgagaag gcgatccata aggagggctg tgtggagaag attgggggct     1260

ggctgaggaa aaatgtgctg gtggtagctg cagcagccct tggaattgct tttgtcgagg     1320

ttttgggaat tgtctttgcc tgctgcctcg tgaagagtat cagaagtggc tacgaggtga     1380

tgtccggtgg aggtggatcc atggcttcta actttactca gttcgttctc gtcgacaatg     1440

gcggaactgg cgacgtgatg aaatcaattc gctgtaaaaa ctgcaacaaa ctgttattta     1500

aggcggattc ctttgatcac attgaaatca ggtgtccgcg ttgcaaacgt cacatcataa     1560

tgctcaacgc ttgtgaacac cctacggaga aacattgtgg gaaaagagaa aaaatcacgc     1620

attctgacga aaccgtgcgt tattag                                          1646


<210>  49
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp 
                245                 250                 255     


Asn Gly Gly Thr Gly Asp Val Met Lys Ser Ile Arg Cys Lys Asn Cys 
            260                 265                 270         


Asn Lys Leu Leu Phe Lys Ala Asp Ser Phe Asp His Ile Glu Ile Arg 
        275                 280                 285             


Cys Pro Arg Cys Lys Arg His Ile Ile Met Leu Asn Ala Cys Glu His 
    290                 295                 300                 


Pro Thr Glu Lys His Cys Gly Lys Arg Glu Lys Ile Thr His Ser Asp 
305                 310                 315                 320 


Glu Thr Val Arg Tyr 
                325 


<210>  50
<211>  1755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatcc gctagccacc      540

atgaaatcaa ttcgctgtaa aaactgcaac aaactgttat ttaaggcgga ttcctttgat      600

cacattgaaa tcaggtgtcc gcgttgcaaa cgtcacatca taatgctcaa cgcttgtgaa      660

caccctacgg agaaacattg tgggaaaaga gaaaaaatca cgcattctga cgaaaccgtg      720

cgttatggcg gtcacaactc cggaggtgga ggtggacaga gcccaggccc ggcagccatg      780

gcggtggaag gaggaatgaa atgtgtgaag ttcttgctct acgtcctcct gctggccttt      840

tgcgcctgtg cagtgggact gattgccgtg ggtgtcgggg cacagcttgt cctgagtcag      900

accataatcc agggggctac ccctggctct ctgttgccag tggtcatcat cgcagtgggt      960

gtcttcctct tcctggtggc ttttgtgggc tgctgcgggg cctgcaagga gaactattgt     1020

cttatgatca cgtttgccat ctttctgtct cttatcatgt tggtggaggt ggccgcagcc     1080

attgctggct atgtgtttag agataaggtg atgtcagagt ttaataacaa cttccggcag     1140

cagatggaga attacccgaa aaataaccac actgcttcga tcctggacag gatgcaggca     1200

gattttaagt gctgtggggc tgctaactac acagattggg agaaaatccc ttccatgtcg     1260

aagaaccgag tccccgactc ctgctgcatt aatgttactg tgggctgtgg gattaatttc     1320

aacgagaagg cgatccataa ggagggctgt gtggagaaga ttgggggctg gctgaggaaa     1380

aatgtgctgg tggtagctgc agcagccctt ggaattgctt ttgtcgaggt tttgggaatt     1440

gtctttgcct gctgcctcgt gaagagtatc agaagtggct acgaggtgat gtccggtgga     1500

ggtggatcca tggcttctaa ctttactcag ttcgttctcg tcgacaatgg cggaactggc     1560

gacgtgatga aatcaattcg ctgtaaaaac tgcaacaaac tgttatttaa ggcggattcc     1620

tttgatcaca ttgaaatcag gtgtccgcgt tgcaaacgtc acatcataat gctcaacgct     1680

tgtgaacacc ctacggagaa acattgtggg aaaagagaaa aaatcacgca ttctgacgaa     1740

accgtgcgtt attag                                                      1755


<210>  51
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr Gly Gly 
    50                  55                  60                  


His Asn Ser Gly Gly Gly Gly Gly Gln Ser Pro Gly Pro Ala Ala Met 
65                  70                  75                  80  


Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu 
                85                  90                  95      


Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val 
            100                 105                 110         


Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro 
        115                 120                 125             


Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe 
    130                 135                 140                 


Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys 
145                 150                 155                 160 


Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu 
                165                 170                 175     


Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser 
            180                 185                 190         


Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn 
        195                 200                 205             


Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys 
    210                 215                 220                 


Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser 
225                 230                 235                 240 


Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys 
                245                 250                 255     


Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu 
            260                 265                 270         


Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala 
        275                 280                 285             


Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys 
    290                 295                 300                 


Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn 
                325                 330                 335     


Gly Gly Thr Gly Asp Val Met Lys Ser Ile Arg Cys Lys Asn Cys Asn 
            340                 345                 350         


Lys Leu Leu Phe Lys Ala Asp Ser Phe Asp His Ile Glu Ile Arg Cys 
        355                 360                 365             


Pro Arg Cys Lys Arg His Ile Ile Met Leu Asn Ala Cys Glu His Pro 
    370                 375                 380                 


Thr Glu Lys His Cys Gly Lys Arg Glu Lys Ile Thr His Ser Asp Glu 
385                 390                 395                 400 


Thr Val Arg Tyr 
                


<210>  52
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52
caccgacaca gacagactac accca                                             25


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53
gataaacacg gcattttgcc ttg                                               23


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54
tccatttcag gtgtcgtgag                                                   20


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55
tccagctcga ccaggatg                                                     18


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56
gaagctatga cagaggaaac g                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57
agccagggct gggcataaaa g                                                 21


<210>  58
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58
tgggaaaata gaccaatagg cagag                                             25


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59
ggcagctgca ggaataagag                                                   20


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60
gctgctcttt ctggcattg                                                    19


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61
tccagccatt gtgttgaatc                                                   20


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62
tcctgttgtt catcatccta gc                                                22


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63
tccagccatt gtgttgaatc                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64
gtttaagggc ccgccttttg                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65
tgtcttacct ctcggtgcct                                                   20


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66
gctgctcttt ctggcattg                                                    19


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67
cagttacagt tattaccgca gca                                               23


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68
gtctgaggtc acacagtggg                                                   20


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  69
agccctgact catcattacc c                                                 21


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  70
aggagtaaga cccctggacc                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71
tctcaccttg acacaagccc                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  72
ctggcattct gggagcttca                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  73
gagacctgtg ggaagcgaaa                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  74
gtctgaggtc acacagtggg                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  75
ctgagagcag ggaccacatc                                                   20


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  76
gcgcttgctc ttcattccct ggg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  77
gtaacggcag acttctcctc agg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  78
actgttgcct ccggttctga agg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  79
gaggacaagt cgtacaatgg tgg                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  80
gatgagataa tgatgagtca ggg                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  81
ccattgttca atatcgtccg ggg                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  82
agccccagca agagcacaag agg                                               23


<210>  83
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  83
tatgtggctt taccaaggtc ccagagt                                           27


<210>  84
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  84
gtgttattac ttgctactgc agagagt                                           27


<210>  85
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  85
acacagacag actacaccca gggaat                                            26


<210>  86
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  86
accggcgctt gctcttcatt ccct                                              24


<210>  87
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  87
accggtaacg gcagacttct ccac                                              24


<210>  88
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  88
accgactgtt gcctccggtt ctga                                              24


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  89
accggaggac aagtcgtaca atgg                                              24


<210>  90
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  90
accggatgag ataatgatga gtca                                              24


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  91
accgccattg ttcaatatcg tccg                                              24


<210>  92
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  92
accgagcccc agcaagagca caag                                              24


<210>  93
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  93
caccgtatgt ggctttacca aggtcc                                            26


<210>  94
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  94
caccgtgtta ttacttgcta ctgca                                             25


<210>  95
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  95
caccgacaca gacagactac accca                                             25


<210>  96
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  96
aaacagggaa tgaagagcaa gcgc                                              24


<210>  97
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  97
aaacgtggag aagtctgccg ttac                                              24


<210>  98
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  98
aaactcagaa ccggaggcaa cagt                                              24


<210>  99
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  99
aaacccattg tacgacttgt cctc                                              24


<210>  100
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  100
aaactgactc atcattatct catc                                              24


<210>  101
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  101
aaaccggacg atattgaaca atgg                                              24


<210>  102
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  102
aaaccttgtg ctcttgctgg ggct                                              24


<210>  103
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  103
aaacggacct tggtaaagcc acatac                                            26


<210>  104
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  104
aaactgcagt agcaagtaat aacac                                             25


<210>  105
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  105
aaactgggtg tagtctgtct gtgtc                                             25


<210>  106
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  106
nngrrt                                                                   6


<210>  107
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  107
nngrrn                                                                   6


<210>  108
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  108
aauaaa                                                                   6


<210>  109
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  109
ttgggggctg gctgaggaa                                                    19


<210>  110
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  110
ccatggatcc acctccaccg gacatcacct cgtagccact tc                          42


<210>  111
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  111
gaagtggcta cgaggtgatg tccggtggag gtggatccat gg                          42


<210>  112
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  112
tagatccggt ggatcagatc tctaataacg cacggtttcg tcag                        44


<210>  113
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  113
tagatccggt ggatcagatc tctaataacg cacggtttcg tcag                        44


<210>  114
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  114
cgggcctggg ctctgtccac ctccacctcc ggagttgtga ccgccataac gcacggtttc       60


<210>  115
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  115

Gly Gly His Asn Ser Gly Gly Gly Gly Gly Gln Ser Pro Gly Pro Ala 
1               5                   10                  15      


Ala 
    


<210>  116
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  116

Ser Gly Gly Gly Gly Ser Met Ala Ser Asn Phe Thr Gln Phe Val Leu 
1               5                   10                  15      


Val Asp Asn Gly Gly Thr Gly Asp Val 
            20                  25  


