                         SEQUENCE LISTING

<110>  Washington University
       BATEMAN, Randall
       HOLTZMAN, David
       BUDELIER, Melissa
       JIANG, Hong
 
<120>  METHODS FOR DETECTING NEUROFILAMENT LIGHT CHAIN IN PLASMA AND 
       CEREBROSPINAL FLUID

<130>  047563-716468

<150>  63/197,826
<151>  2021-06-21

<150>  63/183,417
<151>  2021-05-03

<150>  63/147,833
<151>  2021-02-10

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Phe Ser Tyr Glu Pro Tyr Tyr Ser Thr Ser Tyr Lys Arg 
1               5                   10                  15      


Arg Tyr Val Glu Thr Pro Arg Val His Ile Ser Ser Val Arg Ser Gly 
            20                  25                  30          


Tyr Ser Thr Ala Arg Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser 
        35                  40                  45              


Ser Ser Leu Ser Val Arg Arg Ser Tyr Ser Ser Ser Ser Gly Ser Leu 
    50                  55                  60                  


Met Pro Ser Leu Glu Asn Leu Asp Leu Ser Gln Val Ala Ala Ile Ser 
65                  70                  75                  80  


Asn Asp Leu Lys Ser Ile Arg Thr Gln Glu Lys Ala Gln Leu Gln Asp 
                85                  90                  95      


Leu Asn Asp Arg Phe Ala Ser Phe Ile Glu Arg Val His Glu Leu Glu 
            100                 105                 110         


Gln Gln Asn Lys Val Leu Glu Ala Glu Leu Leu Val Leu Arg Gln Lys 
        115                 120                 125             


His Ser Glu Pro Ser Arg Phe Arg Ala Leu Tyr Glu Gln Glu Ile Arg 
    130                 135                 140                 


Asp Leu Arg Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys Gln Ala Leu 
145                 150                 155                 160 


Gln Gly Glu Arg Glu Gly Leu Glu Glu Thr Leu Arg Asn Leu Gln Ala 
                165                 170                 175     


Arg Tyr Glu Glu Glu Val Leu Ser Arg Glu Asp Ala Glu Gly Arg Leu 
            180                 185                 190         


Met Glu Ala Arg Lys Gly Ala Asp Glu Ala Ala Leu Ala Arg Ala Glu 
        195                 200                 205             


Leu Glu Lys Arg Ile Asp Ser Leu Met Asp Glu Ile Ser Phe Leu Lys 
    210                 215                 220                 


Lys Val His Glu Glu Glu Ile Ala Glu Leu Gln Ala Gln Ile Gln Tyr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Glu Met Asp Val Thr Lys Pro Asp Leu Ser Ala 
                245                 250                 255     


Ala Leu Lys Asp Ile Arg Ala Gln Tyr Glu Lys Leu Ala Ala Lys Asn 
            260                 265                 270         


Met Gln Asn Ala Glu Glu Trp Phe Lys Ser Arg Phe Thr Val Leu Thr 
        275                 280                 285             


Glu Ser Ala Ala Lys Asn Thr Asp Ala Val Arg Ala Ala Lys Asp Glu 
    290                 295                 300                 


Val Ser Glu Ser Arg Arg Leu Leu Lys Ala Lys Thr Leu Glu Ile Glu 
305                 310                 315                 320 


Ala Cys Arg Gly Met Asn Glu Ala Leu Glu Lys Gln Leu Gln Glu Leu 
                325                 330                 335     


Glu Asp Lys Gln Asn Ala Asp Ile Ser Ala Met Gln Asp Thr Ile Asn 
            340                 345                 350         


Lys Leu Glu Asn Glu Leu Arg Thr Thr Lys Ser Glu Met Ala Arg Tyr 
        355                 360                 365             


Leu Lys Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile 
    370                 375                 380                 


Glu Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg Leu 
385                 390                 395                 400 


Ser Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser Ser 
                405                 410                 415     


Gln Val Phe Gly Arg Ser Ala Tyr Gly Gly Leu Gln Thr Ser Ser Tyr 
            420                 425                 430         


Leu Met Ser Thr Arg Ser Phe Pro Ser Tyr Tyr Thr Ser His Val Gln 
        435                 440                 445             


Glu Glu Gln Ile Glu Val Glu Glu Thr Ile Glu Ala Ala Lys Ala Glu 
    450                 455                 460                 


Glu Ala Lys Asp Glu Pro Pro Ser Glu Gly Glu Ala Glu Glu Glu Glu 
465                 470                 475                 480 


Lys Asp Lys Glu Glu Ala Glu Glu Glu Glu Ala Ala Glu Glu Glu Glu 
                485                 490                 495     


Ala Ala Lys Glu Glu Ser Glu Glu Ala Lys Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Glu Gly Glu Glu Gly Glu Glu Thr Lys Glu Ala Glu Glu Glu Glu Lys 
        515                 520                 525             


Lys Val Glu Gly Ala Gly Glu Glu Gln Ala Ala Lys Lys Lys Asp 
    530                 535                 540             


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Tyr Val Glu Thr Pro Arg 
1               5       


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Val His Ile Ser Ser Val Arg 
1               5           


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser Ser Ser Leu Ser Val 
1               5                   10                  15      


Arg 
    


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Ser Tyr Ser Ser Ser Ser Gly Ser Leu Met Pro Ser Leu Glu Asn Leu 
1               5                   10                  15      


Asp Leu Ser Gln Val Ala Ala Ile Ser Asn Asp Leu Lys 
            20                  25                  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Ala Gln Leu Gln Asp Leu Asn Asp Arg 
1               5                   


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Phe Ala Ser Phe Ile Glu Arg 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8

Val His Glu Leu Glu Gln Gln Asn Lys 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Val Leu Glu Ala Glu Leu Leu Val Leu Arg 
1               5                   10  


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Ala Leu Tyr Glu Gln Glu Ile Arg 
1               5               


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys 
1               5                   10  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Gln Ala Leu Gln Gly Glu Arg 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Glu Gly Leu Glu Glu Thr Leu Arg 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Tyr Glu Glu Glu Val Leu Ser Arg 
1               5               


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Leu Met Glu Ala Arg 
1               5   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Gly Ala Asp Glu Ala Ala Leu Ala Arg 
1               5                   


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Ile Asp Ser Leu Met Asp Glu Ile Ser Phe Leu Lys 
1               5                   10          


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Phe Thr Val Leu Thr Glu Ser Ala Ala Lys 
1               5                   10  


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Gly Met Asn Glu Ala Leu Glu Lys 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Gln Leu Gln Glu Leu Glu Asp Lys 
1               5               


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Leu Glu Asn Glu Leu Arg 
1               5       


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Leu Ser Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser 
1               5                   10                  15      


Ser Gln Val Phe Gly Arg 
            20          


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Ser Ala Tyr Gly Gly Leu Gln Thr Ser Ser Tyr Leu Met Ser Thr Arg 
1               5                   10                  15      


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24

Ser Phe Pro Ser Tyr Tyr Thr Ser His Val Gln Glu Glu Gln Ile Glu 
1               5                   10                  15      


Val Glu Glu Thr Ile Glu Ala Ala Lys 
            20                  25  


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Val Glu Gly Ala Gly Glu Glu Gln Ala Ala Lys 
1               5                   10      


