                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       National Cancer Center Research Institute Japan
 
<120>  CCR4-Targeting Chimeric Antigen Receptor Cell Therapy

<130>  046483-7316WO1(02797)

<150>  US 63/148,489
<151>  2021-02-11

<160>  153   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) HCDR1

<400>  1
aactacggca tgagc                                                        15


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) HCDR1

<400>  2

Asn Tyr Gly Met Ser 
1               5   


<210>  3
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) HCDR2

<400>  3
acaatcagca gcgccagcac ctacagctac taccccgata gcgtgaaggg c                51


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) HCDR2

<400>  4

Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) HCDR3

<400>  5
cacagcgacg gcaacttcgc ctttggctat                                        30


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) HCDR3

<400>  6

His Ser Asp Gly Asn Phe Ala Phe Gly Tyr 
1               5                   10  


<210>  7
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) LCDR1

<400>  7
agatccagcc ggaacatcgt gcacatcaac ggcgacacct acctggaa                    48


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) LCDR1

<400>  8

Arg Ser Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) LCDR2

<400>  9
aaggtgtcca accggttcag c                                                 21


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) LCDR2

<400>  10

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  11
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) LCDR3

<400>  11
ttccaaggct ctctgctgcc ctggaca                                           27


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) LCDR3

<400>  12

Phe Gln Gly Ser Leu Leu Pro Trp Thr 
1               5                   


<210>  13
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_H2L) scFv

<400>  13
gaagtgcagc tggttgagtc tggcggagat ctggtgcagc ctggcagaag cctgagactg       60

tcttgtgccg ccagcggctt catcttcagc aactacggca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtcgccaca atcagcagcg ccagcaccta cagctactac      180

cccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgcg cgtggaagat acagccctgt actactgcgg cagacacagc      300

gacggcaatt tcgcctttgg ctattggggc cagggcaccc tggttaccgt ttctagcgga      360

ggaggtggat caggtggagg tggaagcggg ggaggaggtt ccggcggcgg aggatcagat      420

gttctgatga cacagagccc tctgagcctg cctgtgacac ctggcgaacc tgccagcatc      480

agctgcagat ccagccggaa catcgtgcac atcaacggcg acacctacct ggaatggtat      540

ctgcagaagc ccggccagtc tcctcagctg ctgatctaca aggtgtccaa ccggttcagc      600

ggcgtgcccg atagattttc tggcagcggc tctggcaccg acttcaccct gaagatctcc      660

agagtggaag ccgaggacgt gggcgtctac tactgcttcc aaggctctct gctgccctgg      720

acatttggac agggcaccaa ggtggaaatc aag                                   753


<210>  14
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_H2L) scFv

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Gly Arg His Ser Asp Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Met Thr 
    130                 135                 140                 


Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
145                 150                 155                 160 


Ser Cys Arg Ser Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr 
                165                 170                 175     


Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
            180                 185                 190         


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
    210                 215                 220                 


Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  15
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) scFv

<400>  15
gacgtgctga tgacacagag ccctctgagc ctgcctgtga cacctggcga acctgccagc       60

atcagctgca gatccagccg gaacatcgtg cacatcaacg gcgacaccta cctggaatgg      120

tatctgcaga agcccggcca gtctcctcag ctgctgatct acaaggtgtc caaccggttc      180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tctgctgccc      300

tggacatttg gccagggcac caaggtggaa atcaagggag gaggtggatc aggtggaggt      360

ggaagcgggg gaggaggttc cggcggcgga ggatcagaag ttcagctggt tgagtctggc      420

ggcgacctgg ttcagcctgg cagatctctg agactgagct gtgccgccag cggcttcatc      480

ttcagcaact acggcatgag ctgggtccga caggcccctg gaaaaggact ggaatgggtc      540

gccacaatca gcagcgccag cacctacagc tactaccccg atagcgtgaa gggcagattc      600

accatcagcc gggacaacgc caagaacagc ctgtacctgc agatgaactc cctgcgcgtg      660

gaagatacag ccctgtacta ttgcggcaga cacagcgacg gcaacttcgc ctttggctat      720

tggggccagg gaaccctggt caccgtttct agt                                   753


<210>  16
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) scFv

<400>  16

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Asn Ile Val His Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Leu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
145                 150                 155                 160 


Phe Ser Asn Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ala Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr 
            180                 185                 190         


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Gly Arg His Ser Asp Gly Asn Phe Ala Phe Gly Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  17
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(1-49_H2L) scFv

<400>  17
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agcagctgga tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacg      300

tggtatcggc cgaatgacta ctggggccag ggcaccctgg tgaccgtgag cagcggagga      360

ggtggatcag gtggaggtgg aagcggggga ggaggttccg gcggcggagg atcagacatc      420

gtgatgaccc agagccccga cagcctggcc gtgagcctgg gcgagcgggc caccatcaac      480

tgcaagagca gccagagcat cctgtacagc agcaaccaga agaactacct ggcctggtat      540

cagcagaagc ccggccagag ccccaagctg ctgatctact gggccagcac ccgggagagc      600

ggcgtgcccg accggtttag cggcagcggc tccggcaccg acttcaccct gaccatcagc      660

agcctgcagg ccgaggacgt ggccgtgtac tactgccacc agtacaaaag cagctacacc      720

ttcggccagg gcacaaagct ggaaatcaag                                       750


<210>  18
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(1-49_H2L) scFv

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Ser 
            20                  25                  30          


Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Trp Tyr Arg Pro Asn Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
145                 150                 155                 160 


Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
    210                 215                 220                 


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Tyr Lys Ser Ser Tyr Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  19
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(1-49_L2H) scFv

<400>  19
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta caaaagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaagggag gaggtggatc aggtggaggt      360

ggaagcgggg gaggaggttc cggcggcgga ggatcacagg tgcagctggt gcagagcgga      420

gccgaggtga agaagcctgg agcttccgtc aaggtgtcct gcaaggccag cggctacacc      480

ttcgccagca gctggatgca ctggatgcgg caggcacctg gacagggcct cgaatggatc      540

ggctggatca accccggcaa cgtgaacacc aagtacaacg agaagttcaa gggcagggcc      600

accctgaccg tggacaccag caccaacacc gcctacatgg aactgagcag cctgcggagc      660

gaggacaccg ccgtgtacta ctgcgccaga agcacgtggt atcggccgaa tgactactgg      720

ggccagggca ccctggtgac cgtgagcagc                                       750


<210>  20
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(1-49_L2H) scFv

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Lys Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Ala Ser Ser Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr 
            180                 185                 190         


Asn Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr 
        195                 200                 205             


Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Thr Trp Tyr Arg Pro Asn Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250 


<210>  21
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(2-3_H2L) scFv

<400>  21
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agcgcgtgga tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacg      300

tattaccggc cgctggacta ctggggccag ggcaccctgg tgaccgtgag cagcggagga      360

ggtggatcag gtggaggtgg aagcggggga ggaggttccg gcggcggagg atcagacatc      420

gtgatgaccc agagccccga cagcctggcc gtgagcctgg gcgagcgggc caccatcaac      480

tgcaagagca gccagagcat cctgtacagc agcaaccaga agaactacct ggcctggtat      540

cagcagaagc ccggccagag ccccaagctg ctgatctact gggccagcac ccgggagagc      600

ggcgtgcccg accggtttag cggcagcggc tccggcaccg acttcaccct gaccatcagc      660

agcctgcagg ccgaggacgt ggccgtgtac tactgccacc agtacatgag cagctacacc      720

ttcggccagg gcacaaagct ggaaatcaag                                       750


<210>  22
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(2-3_H2L) scFv

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Ala 
            20                  25                  30          


Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
145                 150                 155                 160 


Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
    210                 215                 220                 


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Tyr Met Ser Ser Tyr Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  23
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(2-3_L2H) scFv

<400>  23
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta catgagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaagggag gaggtggatc aggtggaggt      360

ggaagcgggg gaggaggttc cggcggcgga ggatcacagg tgcagctggt gcagagcgga      420

gccgaggtga agaagcctgg agcttccgtc aaggtgtcct gcaaggccag cggctacacc      480

ttcgccagcg cgtggatgca ctggatgcgg caggcacctg gacagggcct cgaatggatc      540

ggctggatca accccggcaa cgtgaacacc aagtacaacg agaagttcaa gggcagggcc      600

accctgaccg tggacaccag caccaacacc gcctacatgg aactgagcag cctgcggagc      660

gaggacaccg ccgtgtacta ctgcgccaga agcacgtatt accggccgct ggactactgg      720

ggccagggca ccctggtgac cgtgagcagc                                       750


<210>  24
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(2-3_L2H) scFv

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Met Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Ala Ser Ala Trp Met His Trp Met Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr 
            180                 185                 190         


Asn Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr 
        195                 200                 205             


Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250 


<210>  25
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(h1567_H2L) scFv

<400>  25
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agctactaca tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacc      300

tactaccggc ccctggacta ctggggccag ggcaccctgg tgaccgtgag cagcggagga      360

ggtggatcag gtggaggtgg aagcggggga ggaggttccg gcggcggagg atcagacatc      420

gtgatgaccc agagccccga cagcctggcc gtgagcctgg gcgagcgggc caccatcaac      480

tgcaagagca gccagagcat cctgtacagc agcaaccaga agaactacct ggcctggtat      540

cagcagaagc ccggccagag ccccaagctg ctgatctact gggccagcac ccgggagagc      600

ggcgtgcccg accggtttag cggcagcggc tccggcaccg acttcaccct gaccatcagc      660

agcctgcagg ccgaggacgt ggccgtgtac tactgccacc agtacctgag cagctacacc      720

ttcggccagg gcacaaagct ggaaatcaag                                       750


<210>  26
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(h1567_H2L) scFv

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn 
145                 150                 155                 160 


Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
    210                 215                 220                 


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Tyr Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  27
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(h1567_L2H) scFv

<400>  27
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta cctgagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaagggag gaggtggatc aggtggaggt      360

ggaagcgggg gaggaggttc cggcggcgga ggatcacagg tgcagctggt gcagagcgga      420

gccgaggtga agaagcctgg agcttccgtc aaggtgtcct gcaaggccag cggctacacc      480

ttcgccagct actacatgca ctggatgcgg caggcacctg gacagggcct cgaatggatc      540

ggctggatca accccggcaa cgtgaacacc aagtacaacg agaagttcaa gggcagggcc      600

accctgaccg tggacaccag caccaacacc gcctacatgg aactgagcag cctgcggagc      660

gaggacaccg ccgtgtacta ctgcgccaga agcacctact accggcccct ggactactgg      720

ggccagggca ccctggtgac cgtgagcagc                                       750


<210>  28
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(h1567_L2H) scFv

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Ala Ser Tyr Tyr Met His Trp Met Arg Gln Ala Pro Gly Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr 
            180                 185                 190         


Asn Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr 
        195                 200                 205             


Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250 


<210>  29
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) CAR

<400>  29
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     1500


<210>  30
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) CAR

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  31
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader

<400>  31
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

ccc                                                                     63


<210>  32
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 leader

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  33
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  33
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  34
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  34

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  35
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane

<400>  35
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  36
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane

<400>  36

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  37
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  37
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  38
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  38

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  39
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  39
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  40

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  41
<211>  2643
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-tEGFR

<400>  41
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atgggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac     1560

cctggaccta tgcttctcct ggtgacaagc cttctgctct gtgagttacc acacccagca     1620

ttcctcctga tcccacgcaa agtgtgtaac ggaataggta ttggtgaatt taaagactca     1680

ctctccataa atgctacgaa tattaaacac ttcaaaaact gcacctccat cagtggcgat     1740

ctccacatcc tgccggtggc atttaggggt gactccttca cacatactcc tcctctggac     1800

ccacaggaac tggatattct gaaaaccgta aaggaaatca cagggttttt gctgattcag     1860

gcttggcctg aaaacaggac ggacctccat gcctttgaga acctagaaat catacgcggc     1920

aggaccaagc aacatggtca gttttctctt gcagtcgtca gcctgaacat aacatccttg     1980

ggattacgct ccctcaagga gataagtgat ggagatgtga taatttcagg aaacaaaaat     2040

ttgtgctatg caaatacaat aaactggaaa aaactgtttg ggacctccgg tcagaaaacc     2100

aaaattataa gcaacagagg tgaaaacagc tgcaaggcca caggccaggt ctgccatgcc     2160

ttgtgctccc ccgagggctg ctggggcccg gagcccaggg actgcgtctc ttgccggaat     2220

gtcagccgag gcagggaatg cgtggacaag tgcaaccttc tggagggtga gccaagggag     2280

tttgtggaga actctgagtg catacagtgc cacccagagt gcctgcctca ggccatgaac     2340

atcacctgca caggacgggg accagacaac tgtatccagt gtgcccacta cattgacggc     2400

ccccactgcg tcaagacctg cccggcagga gtcatgggag aaaacaacac cctggtctgg     2460

aagtacgcag acgccggcca tgtgtgccac ctgtgccatc caaactgcac ctacggatgc     2520

actgggccag gtcttgaagg ctgtccaacg aatgggccta agatcccgtc catcgccact     2580

gggatggtgg gggccctcct cttgctgctg gtggtggccc tggggatcgg cctcttcatg     2640

tag                                                                   2643


<210>  42
<211>  880
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-tEGFR

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
            500                 505                 510         


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Val 
        515                 520                 525             


Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile 
    530                 535                 540                 


Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
545                 550                 555                 560 


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
                565                 570                 575     


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
            580                 585                 590         


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
        595                 600                 605             


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
    610                 615                 620                 


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
625                 630                 635                 640 


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
                645                 650                 655     


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
            660                 665                 670         


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
        675                 680                 685             


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
    690                 695                 700                 


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
705                 710                 715                 720 


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
                725                 730                 735     


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
            740                 745                 750         


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
        755                 760                 765             


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
    770                 775                 780                 


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
785                 790                 795                 800 


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
                805                 810                 815     


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
            820                 825                 830         


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
        835                 840                 845             


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
    850                 855                 860                 


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
865                 870                 875                 880 


<210>  43
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  43
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atg                                                                   1503


<210>  44
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met 
            500     


<210>  45
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  45
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  46
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  46

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  47
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GMSCFR leader

<400>  47
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atccca                                                                  66


<210>  48
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMSCFR leader

<400>  48

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  49
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tEGFR

<400>  49
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggacccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag      780

acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc      840

ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg gccaggtctt      900

gaaggctgtc caacgaatgg gcctaagatc ccgtccatcg ccactgggat ggtgggggcc      960

ctcctcttgc tgctggtggt ggccctgggg atcggcctct tcatgtag                  1008


<210>  50
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tEGFR

<400>  50

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  51
<211>  2463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-CD20

<400>  51
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atgggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac     1560

cctggaccta tgacaacacc cagaaattca gtaaatggga ctttcccggc agagccaatg     1620

aaaggcccta ttgctatgca atctggtcca aaaccactct tcaggaggat gtcttcactg     1680

gtgggcccca cgcaatcctt cttcatgagg gaatctaaga ctttgggggc tgtccagatt     1740

atgaatgggc tcttccacat tgccctgggg ggtcttctga tgatcccagc agggatctat     1800

gcacccatct gtgtgactgt gtggtatcct ctctggggag gcattatgta tattatttcc     1860

ggatcactcc tggcagcaac ggagaaaaac tccaggaagt gtttggtcaa aggaaaaatg     1920

ataatgaact cattgagcct ctttgctgcc atttctggaa tgattctttc aatcatggac     1980

atacttaata ttaaaatttc ccatttttta aaaatggaga gtctgaattt tattagagct     2040

cacacaccat atattaacat atacaactgt gaaccagcta atccctctga gaaaaactcc     2100

ccatctaccc aatactgtta cagcatacaa tctctgttct tgggcatttt gtcagtgatg     2160

ctgatctttg ccttcttcca ggaacttgta atagctggca tcgttgagaa tgaatggaaa     2220

agaacgtgct ccagacccaa atctaacata gttctcctgt cagcagaaga aaaaaaagaa     2280

cagactattg aaataaaaga agaagtggtt gggctaactg aaacatcttc ccaaccaaag     2340

aatgaagaag acattgaaat tattccaatc caagaagagg aagaagaaga aacagagacg     2400

aactttccag aacctcccca agatcaggaa tcctcaccaa tagaaaatga cagctctcct     2460

taa                                                                   2463


<210>  52
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-CD20

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
            500                 505                 510         


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Thr Thr Pro Arg 
        515                 520                 525             


Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro Met Lys Gly Pro Ile 
    530                 535                 540                 


Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg Arg Met Ser Ser Leu 
545                 550                 555                 560 


Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu Ser Lys Thr Leu Gly 
                565                 570                 575     


Ala Val Gln Ile Met Asn Gly Leu Phe His Ile Ala Leu Gly Gly Leu 
            580                 585                 590         


Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile Cys Val Thr Val Trp 
        595                 600                 605             


Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile Ser Gly Ser Leu Leu 
    610                 615                 620                 


Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu Val Lys Gly Lys Met 
625                 630                 635                 640 


Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile Ser Gly Met Ile Leu 
                645                 650                 655     


Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser His Phe Leu Lys Met 
            660                 665                 670         


Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr Ile Asn Ile Tyr 
        675                 680                 685             


Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser Thr Gln 
    690                 695                 700                 


Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile Leu Ser Val Met 
705                 710                 715                 720 


Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala Gly Ile Val Glu 
                725                 730                 735     


Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser Asn Ile Val Leu 
            740                 745                 750         


Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu Ile Lys Glu Glu 
        755                 760                 765             


Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys Asn Glu Glu Asp 
    770                 775                 780                 


Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu Glu Thr Glu Thr 
785                 790                 795                 800 


Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser Pro Ile Glu Asn 
                805                 810                 815     


Asp Ser Ser Pro 
            820 


<210>  53
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  53
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atg                                                                   1503


<210>  54
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met 
            500     


<210>  55
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  55
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  56
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  56

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  57
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD20

<400>  57
atgacaacac ccagaaattc agtaaatggg actttcccgg cagagccaat gaaaggccct       60

attgctatgc aatctggtcc aaaaccactc ttcaggagga tgtcttcact ggtgggcccc      120

acgcaatcct tcttcatgag ggaatctaag actttggggg ctgtccagat tatgaatggg      180

ctcttccaca ttgccctggg gggtcttctg atgatcccag cagggatcta tgcacccatc      240

tgtgtgactg tgtggtatcc tctctgggga ggcattatgt atattatttc cggatcactc      300

ctggcagcaa cggagaaaaa ctccaggaag tgtttggtca aaggaaaaat gataatgaac      360

tcattgagcc tctttgctgc catttctgga atgattcttt caatcatgga catacttaat      420

attaaaattt cccatttttt aaaaatggag agtctgaatt ttattagagc tcacacacca      480

tatattaaca tatacaactg tgaaccagct aatccctctg agaaaaactc cccatctacc      540

caatactgtt acagcataca atctctgttc ttgggcattt tgtcagtgat gctgatcttt      600

gccttcttcc aggaacttgt aatagctggc atcgttgaga atgaatggaa aagaacgtgc      660

tccagaccca aatctaacat agttctcctg tcagcagaag aaaaaaaaga acagactatt      720

gaaataaaag aagaagtggt tgggctaact gaaacatctt cccaaccaaa gaatgaagaa      780

gacattgaaa ttattccaat ccaagaagag gaagaagaag aaacagagac gaactttcca      840

gaacctcccc aagatcagga atcctcacca atagaaaatg acagctctcc ttaa            894


<210>  58
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20

<400>  58

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  59
<211>  2754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-FKBP-iCasp9

<400>  59
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atgggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac     1560

cctggacctg gagtgcaggt ggagactatc tccccaggag acgggcgcac cttccccaag     1620

cgcggccaga cctgcgtggt gcactacacc gggatgcttg aagatggaaa gaaagttgat     1680

tcctcccggg acagaaacaa gccctttaag tttatgctag gcaagcagga ggtgatccga     1740

ggctgggaag aaggggttgc ccagatgagt gtgggtcaga gagccaaact gactatatct     1800

ccagattatg cctatggtgc cactgggcac ccaggcatca tcccaccaca tgccactctc     1860

gtcttcgatg tggagcttct aaaactggaa tctggcggtg gctccggatt tggtgatgtc     1920

ggtgctcttg agagtttgag gggaaatgca gatttggctt acatcctgag catggagccc     1980

tgtggccact gcctcattat caacaatgtg aacttctgcc gtgagtccgg gctccgcacc     2040

cgcactggct ccaacatcga ctgtgagaag ttgcggcgtc gcttctcctc gctgcatttc     2100

atggtggagg tgaagggcga cctgactgcc aagaaaatgg tgctggcttt gctggagctg     2160

gcgcggcagg accacggtgc tctggactgc tgcgtggtgg tcattctctc tcacggctgt     2220

caggccagcc acctgcagtt cccaggggct gtctacggca cagatggatg ccctgtgtcg     2280

gtcgagaaga ttgtgaacat cttcaatggg accagctgcc ccagcctggg agggaagccc     2340

aagctctttt tcatccaggc ctgtggtggg gagcagaaag accatgggtt tgaggtggcc     2400

tccacttccc ctgaagacga gtcccctggc agtaaccccg agccagatgc caccccgttc     2460

caggaaggtt tgaggacctt cgaccagctg gacgccatat ctagtttgcc cacacccagt     2520

gacatctttg tgtcctactc tactttccca ggttttgttt cctggaggga ccccaagagt     2580

ggctcctggt acgttgagac cctggacgac atctttgagc agtgggctca ctctgaagac     2640

ctgcagtccc tcctgcttag ggtcgctaat gctgtttcgg tgaaagggat ttataaacag     2700

atgcctggtt gctttaattt cctccggaaa aaacttttct ttaaaacatc ataa           2754


<210>  60
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-FKBP-iCasp9

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
            500                 505                 510         


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Val Gln Val Glu 
        515                 520                 525             


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
    530                 535                 540                 


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
545                 550                 555                 560 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
                565                 570                 575     


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
            580                 585                 590         


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
        595                 600                 605             


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
    610                 615                 620                 


Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Ser Gly Phe Gly Asp Val 
625                 630                 635                 640 


Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu 
                645                 650                 655     


Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe 
            660                 665                 670         


Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys 
        675                 680                 685             


Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val 
    690                 695                 700                 


Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu 
705                 710                 715                 720 


Ala Arg Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu 
                725                 730                 735     


Ser His Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr 
            740                 745                 750         


Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe 
        755                 760                 765             


Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe 
    770                 775                 780                 


Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala 
785                 790                 795                 800 


Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp 
                805                 810                 815     


Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala 
            820                 825                 830         


Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr 
        835                 840                 845             


Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr 
    850                 855                 860                 


Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp 
865                 870                 875                 880 


Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly 
                885                 890                 895     


Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu 
            900                 905                 910         


Phe Phe Lys Thr Ser 
        915         


<210>  61
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  61
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atg                                                                   1503


<210>  62
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met 
            500     


<210>  63
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  63
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  64
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  64

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  65
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FKBP-iCasp9

<400>  65
ggagtgcagg tggagactat ctccccagga gacgggcgca ccttccccaa gcgcggccag       60

acctgcgtgg tgcactacac cgggatgctt gaagatggaa agaaagttga ttcctcccgg      120

gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg aggctgggaa      180

gaaggggttg cccagatgag tgtgggtcag agagccaaac tgactatatc tccagattat      240

gcctatggtg ccactgggca cccaggcatc atcccaccac atgccactct cgtcttcgat      300

gtggagcttc taaaactgga atctggcggt ggctccggat ttggtgatgt cggtgctctt      360

gagagtttga ggggaaatgc agatttggct tacatcctga gcatggagcc ctgtggccac      420

tgcctcatta tcaacaatgt gaacttctgc cgtgagtccg ggctccgcac ccgcactggc      480

tccaacatcg actgtgagaa gttgcggcgt cgcttctcct cgctgcattt catggtggag      540

gtgaagggcg acctgactgc caagaaaatg gtgctggctt tgctggagct ggcgcggcag      600

gaccacggtg ctctggactg ctgcgtggtg gtcattctct ctcacggctg tcaggccagc      660

cacctgcagt tcccaggggc tgtctacggc acagatggat gccctgtgtc ggtcgagaag      720

attgtgaaca tcttcaatgg gaccagctgc cccagcctgg gagggaagcc caagctcttt      780

ttcatccagg cctgtggtgg ggagcagaaa gaccatgggt ttgaggtggc ctccacttcc      840

cctgaagacg agtcccctgg cagtaacccc gagccagatg ccaccccgtt ccaggaaggt      900

ttgaggacct tcgaccagct ggacgccata tctagtttgc ccacacccag tgacatcttt      960

gtgtcctact ctactttccc aggttttgtt tcctggaggg accccaagag tggctcctgg     1020

tacgttgaga ccctggacga catctttgag cagtgggctc actctgaaga cctgcagtcc     1080

ctcctgctta gggtcgctaa tgctgtttcg gtgaaaggga tttataaaca gatgcctggt     1140

tgctttaatt tcctccggaa aaaacttttc tttaaaacat cataa                     1185


<210>  66
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP-iCasp9

<400>  66

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp 
        115                 120                 125             


Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile 
    130                 135                 140                 


Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly 
145                 150                 155                 160 


Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His 
                165                 170                 175     


Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu 
            180                 185                 190         


Ala Leu Leu Glu Leu Ala Arg Gln Asp His Gly Ala Leu Asp Cys Cys 
        195                 200                 205             


Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe 
    210                 215                 220                 


Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys 
225                 230                 235                 240 


Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys 
                245                 250                 255     


Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His 
            260                 265                 270         


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
        275                 280                 285             


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
    290                 295                 300                 


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
305                 310                 315                 320 


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
                325                 330                 335     


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
            340                 345                 350         


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
        355                 360                 365             


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
    370                 375                 380                 


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
385                 390                 


<210>  67
<211>  2694
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-HSVTK

<400>  67
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga     1500

agcggagcta ctaacttcag cctgctgaag caggctggag acgtggagga gaaccctgga     1560

cctatggctt cgtacccctg ccatcaacac gcgtctgcgt tcgaccaggc tgcgcgttct     1620

cgcggccata gcaaccgacg tacggcgttg cgccctcgcc ggcagcaaga agccacggaa     1680

gtccgcctgg agcagaaaat gcccacgcta ctgcgggttt atatagacgg tcctcacggg     1740

atggggaaaa ccaccaccac gcaactgctg gtggccctgg gttcgcgcga cgatatcgtc     1800

tacgtacccg agccgatgac ttactggcag gtgctggggg cttccgagac aatcgcgaac     1860

atctacacca cacaacaccg cctcgaccag ggcgagatat cggccgggga cgcggcggtg     1920

gtaatgacaa gcgcccagat aacaatgggc atgccttatg ccgtgaccga cgccgttctg     1980

gctcctcatg tcggggggga ggctgggagt tcacatgccc cgcccccggc cctcaccctc     2040

atcttcgacc gccatcccat cgccgccctc ctgtgctacc cggccgcgcg ataccttatg     2100

ggcagcatga ccccccaggc cgtgctggcg ttcgtggccc tcatcccgcc gaccttgccc     2160

ggcacaaaca tcgtgttggg ggcccttccg gaggacagac acatcgaccg cctggccaaa     2220

cgccagcgcc ccggcgagcg gcttgacctg gctatgctgg ccgcgattcg ccgcgtttac     2280

gggctgcttg ccaatacggt gcggtatctg cagggcggcg ggtcgtggtg ggaggattgg     2340

ggacagcttt cggggacggc cgtgccgccc cagggtgccg agccccagag caacgcgggc     2400

ccacgacccc atatcgggga cacgttattt accctgtttc gggcccccga gttgctggcc     2460

cccaacggcg acctgtataa cgtgtttgcc tgggccttgg acgtcttggc caaacgcctc     2520

cgtcccatgc acgtctttat cctggattac gaccaatcgc ccgccggctg ccgggacgcc     2580

ctgctgcaac ttacctccgg gatggtccag acccacgtca ccaccccagg ctccataccg     2640

acgatctgcg acctggcgcg cacgtttgcc cgggagatgg gggaggctaa ctaa           2694


<210>  68
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-HSVTK

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
            500                 505                 510         


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Tyr Pro Cys His 
        515                 520                 525             


Gln His Ala Ser Ala Phe Asp Gln Ala Ala Arg Ser Arg Gly His Ser 
    530                 535                 540                 


Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln Gln Glu Ala Thr Glu 
545                 550                 555                 560 


Val Arg Leu Glu Gln Lys Met Pro Thr Leu Leu Arg Val Tyr Ile Asp 
                565                 570                 575     


Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr Gln Leu Leu Val Ala 
            580                 585                 590         


Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro Glu Pro Met Thr Tyr 
        595                 600                 605             


Trp Gln Val Leu Gly Ala Ser Glu Thr Ile Ala Asn Ile Tyr Thr Thr 
    610                 615                 620                 


Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala Gly Asp Ala Ala Val 
625                 630                 635                 640 


Val Met Thr Ser Ala Gln Ile Thr Met Gly Met Pro Tyr Ala Val Thr 
                645                 650                 655     


Asp Ala Val Leu Ala Pro His Val Gly Gly Glu Ala Gly Ser Ser His 
            660                 665                 670         


Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe Asp Arg His Pro Ile Ala 
        675                 680                 685             


Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met Gly Ser Met Thr 
    690                 695                 700                 


Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile Pro Pro Thr Leu Pro 
705                 710                 715                 720 


Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu Asp Arg His Ile Asp 
                725                 730                 735     


Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg Leu Asp Leu Ala Met 
            740                 745                 750         


Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu Leu Ala Asn Thr Val Arg 
        755                 760                 765             


Tyr Leu Gln Gly Gly Gly Ser Trp Trp Glu Asp Trp Gly Gln Leu Ser 
    770                 775                 780                 


Gly Thr Ala Val Pro Pro Gln Gly Ala Glu Pro Gln Ser Asn Ala Gly 
785                 790                 795                 800 


Pro Arg Pro His Ile Gly Asp Thr Leu Phe Thr Leu Phe Arg Ala Pro 
                805                 810                 815     


Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr Asn Val Phe Ala Trp Ala 
            820                 825                 830         


Leu Asp Val Leu Ala Lys Arg Leu Arg Pro Met His Val Phe Ile Leu 
        835                 840                 845             


Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg Asp Ala Leu Leu Gln Leu 
    850                 855                 860                 


Thr Ser Gly Met Val Gln Thr His Val Thr Thr Pro Gly Ser Ile Pro 
865                 870                 875                 880 


Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala Arg Glu Met Gly Glu Ala 
                885                 890                 895     


Asn 
    


<210>  69
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  69
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgccat     1500

atg                                                                   1503


<210>  70
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg His Met 
            500     


<210>  71
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  71
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  72
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  72

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  73
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  73
atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc       60

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc      120

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc tcacgggatg      180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac      240

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc      300

tacaccacac aacaccgcct cgaccagggc gagatatcgg ccggggacgc ggcggtggta      360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct      420

cctcatgtcg ggggggaggc tgggagttca catgccccgc ccccggccct caccctcatc      480

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc      540

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc      600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc      660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacggg      720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggtggga ggattgggga      780

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca      840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc      900

aacggcgacc tgtataacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt      960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg     1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca ccccaggctc cataccgacg     1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaacta a              1131


<210>  74
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  74

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  75
<211>  3423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dnTGFRII-CCR4(KW_L2H)-HSVTK

<400>  75
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggatgtgg aaatggaggc ccagaaagat      120

gaaatcatct gccccagctg taataggact gcccatccac tgagacatat taataacgac      180

atgatagtca ctgacaacaa cggtgcagtc aagtttccac aactgtgtaa attttgtgat      240

gtgagatttt ccacctgtga caaccagaaa tcctgcatga gcaactgcag catcacctcc      300

atctgtgaga agccacagga agtctgtgtg gctgtatgga gaaagaatga cgagaacata      360

acactagaga cagtttgcca tgaccccaag ctcccctacc atgactttat tctggaagat      420

gctgcttctc caaagtgcat tatgaaggaa aaaaaaaagc ctggtgagac tttcttcatg      480

tgttcctgta gctctgatga gtgcaatgac aacatcatct tctcagaaga atataacacc      540

agcaatcctg acttgttgct agtcatattt caagtgacag gcatcagcct cctgccacca      600

ctgggagttg ccatatctgt catcatcatc ttctactgct accgcgttaa ccggcagcag      660

aagctgggca gcggcgaggg cagaggcagc ctgctgacct gcggcgacgt ggaggagaac      720

cccggaccta tggccctgcc tgtgacagcc ctgctgctgc ctctggctct gctgctgcat      780

gccgctagac ccggatccga cgtgctgatg acacagagcc ctctgagcct gcctgtgaca      840

cctggcgaac ctgccagcat cagctgcaga tccagccgga acatcgtgca catcaacggc      900

gacacctacc tggaatggta tctgcagaag cccggccagt ctcctcagct gctgatctac      960

aaggtgtcca accggttcag cggcgtgccc gatagatttt ctggcagcgg ctctggcacc     1020

gacttcaccc tgaagatctc cagagtggaa gccgaggacg tgggcgtgta ctactgcttc     1080

caaggctctc tgctgccctg gacatttggc cagggcacca aggtggaaat caagggagga     1140

ggtggatcag gtggaggtgg aagcggggga ggaggttccg gcggcggagg atcagaagtt     1200

cagctggttg agtctggcgg cgacctggtt cagcctggca gatctctgag actgagctgt     1260

gccgccagcg gcttcatctt cagcaactac ggcatgagct gggtccgaca ggcccctgga     1320

aaaggactgg aatgggtcgc cacaatcagc agcgccagca cctacagcta ctaccccgat     1380

agcgtgaagg gcagattcac catcagccgg gacaacgcca agaacagcct gtacctgcag     1440

atgaactccc tgcgcgtgga agatacagcc ctgtactatt gcggcagaca cagcgacggc     1500

aacttcgcct ttggctattg gggccaggga accctggtca ccgtttctag ttccggaacc     1560

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc     1620

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac     1680

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     1740

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1800

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1860

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1920

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1980

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     2040

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     2100

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     2160

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     2220

cctcgcggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag     2280

aaccctggac ctatggcttc gtacccctgc catcaacacg cgtctgcgtt cgaccaggct     2340

gcgcgttctc gcggccatag caaccgacgt acggcgttgc gccctcgccg gcagcaagaa     2400

gccacggaag tccgcctgga gcagaaaatg cccacgctac tgcgggttta tatagacggt     2460

cctcacggga tggggaaaac caccaccacg caactgctgg tggccctggg ttcgcgcgac     2520

gatatcgtct acgtacccga gccgatgact tactggcagg tgctgggggc ttccgagaca     2580

atcgcgaaca tctacaccac acaacaccgc ctcgaccagg gcgagatatc ggccggggac     2640

gcggcggtgg taatgacaag cgcccagata acaatgggca tgccttatgc cgtgaccgac     2700

gccgttctgg ctcctcatgt cgggggggag gctgggagtt cacatgcccc gcccccggcc     2760

ctcaccctca tcttcgaccg ccatcccatc gccgccctcc tgtgctaccc ggccgcgcga     2820

taccttatgg gcagcatgac cccccaggcc gtgctggcgt tcgtggccct catcccgccg     2880

accttgcccg gcacaaacat cgtgttgggg gcccttccgg aggacagaca catcgaccgc     2940

ctggccaaac gccagcgccc cggcgagcgg cttgacctgg ctatgctggc cgcgattcgc     3000

cgcgtttacg ggctgcttgc caatacggtg cggtatctgc agggcggcgg gtcgtggtgg     3060

gaggattggg gacagctttc ggggacggcc gtgccgcccc agggtgccga gccccagagc     3120

aacgcgggcc cacgacccca tatcggggac acgttattta ccctgtttcg ggcccccgag     3180

ttgctggccc ccaacggcga cctgtataac gtgtttgcct gggccttgga cgtcttggcc     3240

aaacgcctcc gtcccatgca cgtctttatc ctggattacg accaatcgcc cgccggctgc     3300

cgggacgccc tgctgcaact tacctccggg atggtccaga cccacgtcac caccccaggc     3360

tccataccga cgatctgcga cctggcgcgc acgtttgccc gggagatggg ggaggctaac     3420

taa                                                                   3423


<210>  76
<211>  1140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGFRII-CCR4(KW_L2H)-HSVTK

<400>  76

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Gly Ser 
    210                 215                 220                 


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
225                 230                 235                 240 


Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala 
                245                 250                 255     


Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln 
            260                 265                 270         


Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser 
        275                 280                 285             


Cys Arg Ser Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu 
    290                 295                 300                 


Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
305                 310                 315                 320 


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
            340                 345                 350         


Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr 
        355                 360                 365             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
385                 390                 395                 400 


Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu 
                405                 410                 415     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met 
            420                 425                 430         


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr 
        435                 440                 445             


Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly 
    450                 455                 460                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
465                 470                 475                 480 


Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg 
                485                 490                 495     


His Ser Asp Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu 
            500                 505                 510         


Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        515                 520                 525             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    530                 535                 540                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
545                 550                 555                 560 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                565                 570                 575     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
            580                 585                 590         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        595                 600                 605             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    610                 615                 620                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
625                 630                 635                 640 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                645                 650                 655     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            660                 665                 670         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        675                 680                 685             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    690                 695                 700                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
705                 710                 715                 720 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                725                 730                 735     


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
            740                 745                 750         


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Tyr 
        755                 760                 765             


Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala Ala Arg Ser Arg 
    770                 775                 780                 


Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln Gln Glu 
785                 790                 795                 800 


Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr Leu Leu Arg Val 
                805                 810                 815     


Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr Gln Leu 
            820                 825                 830         


Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro Glu Pro 
        835                 840                 845             


Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr Ile Ala Asn Ile 
    850                 855                 860                 


Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala Gly Asp 
865                 870                 875                 880 


Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly Met Pro Tyr 
                885                 890                 895     


Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly Gly Glu Ala Gly 
            900                 905                 910         


Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe Asp Arg His 
        915                 920                 925             


Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met Gly 
    930                 935                 940                 


Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile Pro Pro 
945                 950                 955                 960 


Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu Asp Arg 
                965                 970                 975     


His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg Leu Asp 
            980                 985                 990         


Leu Ala Met Leu Ala Ala Ile Arg  Arg Val Tyr Gly Leu  Leu Ala Asn 
        995                 1000                 1005             


Thr Val  Arg Tyr Leu Gln Gly  Gly Gly Ser Trp Trp  Glu Asp Trp 
    1010                 1015                 1020             


Gly Gln  Leu Ser Gly Thr Ala  Val Pro Pro Gln Gly  Ala Glu Pro 
    1025                 1030                 1035             


Gln Ser  Asn Ala Gly Pro Arg  Pro His Ile Gly Asp  Thr Leu Phe 
    1040                 1045                 1050             


Thr Leu  Phe Arg Ala Pro Glu  Leu Leu Ala Pro Asn  Gly Asp Leu 
    1055                 1060                 1065             


Tyr Asn  Val Phe Ala Trp Ala  Leu Asp Val Leu Ala  Lys Arg Leu 
    1070                 1075                 1080             


Arg Pro  Met His Val Phe Ile  Leu Asp Tyr Asp Gln  Ser Pro Ala 
    1085                 1090                 1095             


Gly Cys  Arg Asp Ala Leu Leu  Gln Leu Thr Ser Gly  Met Val Gln 
    1100                 1105                 1110             


Thr His  Val Thr Thr Pro Gly  Ser Ile Pro Thr Ile  Cys Asp Leu 
    1115                 1120                 1125             


Ala Arg  Thr Phe Ala Arg Glu  Met Gly Glu Ala Asn  
    1130                 1135                 1140 


<210>  77
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dnTGNbRII

<400>  77
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggatgtgg aaatggaggc ccagaaagat      120

gaaatcatct gccccagctg taataggact gcccatccac tgagacatat taataacgac      180

atgatagtca ctgacaacaa cggtgcagtc aagtttccac aactgtgtaa attttgtgat      240

gtgagatttt ccacctgtga caaccagaaa tcctgcatga gcaactgcag catcacctcc      300

atctgtgaga agccacagga agtctgtgtg gctgtatgga gaaagaatga cgagaacata      360

acactagaga cagtttgcca tgaccccaag ctcccctacc atgactttat tctggaagat      420

gctgcttctc caaagtgcat tatgaaggaa aaaaaaaagc ctggtgagac tttcttcatg      480

tgttcctgta gctctgatga gtgcaatgac aacatcatct tctcagaaga atataacacc      540

agcaatcctg acttgttgct agtcatattt caagtgacag gcatcagcct cctgccacca      600

ctgggagttg ccatatctgt catcatcatc ttctactgct accgcgttaa ccggcagcag      660

aagctg                                                                 666


<210>  78
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGNbRII

<400>  78

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu 
    210                 215                 220         


<210>  79
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  79
ggcagcggcg agggcagagg cagcctgctg acctgcggcg acgtggagga gaaccccgga       60

cct                                                                     63


<210>  80
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  80

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  81
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  81
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        1497


<210>  82
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  82

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  83
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  83
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  84
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  84

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  85
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  85
atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc       60

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc      120

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc tcacgggatg      180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac      240

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc      300

tacaccacac aacaccgcct cgaccagggc gagatatcgg ccggggacgc ggcggtggta      360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct      420

cctcatgtcg ggggggaggc tgggagttca catgccccgc ccccggccct caccctcatc      480

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc      540

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc      600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc      660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacggg      720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggtggga ggattgggga      780

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca      840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc      900

aacggcgacc tgtataacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt      960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg     1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca ccccaggctc cataccgacg     1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaacta a              1131


<210>  86
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  86

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  87
<211>  3423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-dnTGFbRII-HSVTK

<400>  87
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga     1500

agcggagcta ctaacttcag cctgctgaag caggctggag acgtggagga gaaccctgga     1560

cctatgggtc gggggctgct caggggcctg tggccgctgc acatcgtcct gtggacgcgt     1620

atcgccagca cgatcccacc gcacgttcag aagtcggatg tggaaatgga ggcccagaaa     1680

gatgaaatca tctgccccag ctgtaatagg actgcccatc cactgagaca tattaataac     1740

gacatgatag tcactgacaa caacggtgca gtcaagtttc cacaactgtg taaattttgt     1800

gatgtgagat tttccacctg tgacaaccag aaatcctgca tgagcaactg cagcatcacc     1860

tccatctgtg agaagccaca ggaagtctgt gtggctgtat ggagaaagaa tgacgagaac     1920

ataacactag agacagtttg ccatgacccc aagctcccct accatgactt tattctggaa     1980

gatgctgctt ctccaaagtg cattatgaag gaaaaaaaaa agcctggtga gactttcttc     2040

atgtgttcct gtagctctga tgagtgcaat gacaacatca tcttctcaga agaatataac     2100

accagcaatc ctgacttgtt gctagtcata tttcaagtga caggcatcag cctcctgcca     2160

ccactgggag ttgccatatc tgtcatcatc atcttctact gctaccgcgt taaccggcag     2220

cagaagctgg gcagcggcga gggcagaggc agcctgctga cctgcggcga cgtggaggag     2280

aaccccggac ctatggcttc gtacccctgc catcaacacg cgtctgcgtt cgaccaggct     2340

gcgcgttctc gcggccatag caaccgacgt acggcgttgc gccctcgccg gcagcaagaa     2400

gccacggaag tccgcctgga gcagaaaatg cccacgctac tgcgggttta tatagacggt     2460

cctcacggga tggggaaaac caccaccacg caactgctgg tggccctggg ttcgcgcgac     2520

gatatcgtct acgtacccga gccgatgact tactggcagg tgctgggggc ttccgagaca     2580

atcgcgaaca tctacaccac acaacaccgc ctcgaccagg gcgagatatc ggccggggac     2640

gcggcggtgg taatgacaag cgcccagata acaatgggca tgccttatgc cgtgaccgac     2700

gccgttctgg ctcctcatgt cgggggggag gctgggagtt cacatgcccc gcccccggcc     2760

ctcaccctca tcttcgaccg ccatcccatc gccgccctcc tgtgctaccc ggccgcgcga     2820

taccttatgg gcagcatgac cccccaggcc gtgctggcgt tcgtggccct catcccgccg     2880

accttgcccg gcacaaacat cgtgttgggg gcccttccgg aggacagaca catcgaccgc     2940

ctggccaaac gccagcgccc cggcgagcgg cttgacctgg ctatgctggc cgcgattcgc     3000

cgcgtttacg ggctgcttgc caatacggtg cggtatctgc agggcggcgg gtcgtggtgg     3060

gaggattggg gacagctttc ggggacggcc gtgccgcccc agggtgccga gccccagagc     3120

aacgcgggcc cacgacccca tatcggggac acgttattta ccctgtttcg ggcccccgag     3180

ttgctggccc ccaacggcga cctgtataac gtgtttgcct gggccttgga cgtcttggcc     3240

aaacgcctcc gtcccatgca cgtctttatc ctggattacg accaatcgcc cgccggctgc     3300

cgggacgccc tgctgcaact tacctccggg atggtccaga cccacgtcac caccccaggc     3360

tccataccga cgatctgcga cctggcgcgc acgtttgccc gggagatggg ggaggctaac     3420

taa                                                                   3423


<210>  88
<211>  1140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-dnTGFbRII-HSVTK

<400>  88

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
            500                 505                 510         


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg 
        515                 520                 525             


Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr 
    530                 535                 540                 


Ile Pro Pro His Val Gln Lys Ser Asp Val Glu Met Glu Ala Gln Lys 
545                 550                 555                 560 


Asp Glu Ile Ile Cys Pro Ser Cys Asn Arg Thr Ala His Pro Leu Arg 
                565                 570                 575     


His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            580                 585                 590         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        595                 600                 605             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    610                 615                 620                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
625                 630                 635                 640 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                645                 650                 655     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            660                 665                 670         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        675                 680                 685             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    690                 695                 700                 


Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro 
705                 710                 715                 720 


Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg 
                725                 730                 735     


Val Asn Arg Gln Gln Lys Leu Gly Ser Gly Glu Gly Arg Gly Ser Leu 
            740                 745                 750         


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Tyr 
        755                 760                 765             


Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala Ala Arg Ser Arg 
    770                 775                 780                 


Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln Gln Glu 
785                 790                 795                 800 


Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr Leu Leu Arg Val 
                805                 810                 815     


Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr Gln Leu 
            820                 825                 830         


Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro Glu Pro 
        835                 840                 845             


Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr Ile Ala Asn Ile 
    850                 855                 860                 


Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala Gly Asp 
865                 870                 875                 880 


Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly Met Pro Tyr 
                885                 890                 895     


Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly Gly Glu Ala Gly 
            900                 905                 910         


Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe Asp Arg His 
        915                 920                 925             


Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met Gly 
    930                 935                 940                 


Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile Pro Pro 
945                 950                 955                 960 


Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu Asp Arg 
                965                 970                 975     


His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg Leu Asp 
            980                 985                 990         


Leu Ala Met Leu Ala Ala Ile Arg  Arg Val Tyr Gly Leu  Leu Ala Asn 
        995                 1000                 1005             


Thr Val  Arg Tyr Leu Gln Gly  Gly Gly Ser Trp Trp  Glu Asp Trp 
    1010                 1015                 1020             


Gly Gln  Leu Ser Gly Thr Ala  Val Pro Pro Gln Gly  Ala Glu Pro 
    1025                 1030                 1035             


Gln Ser  Asn Ala Gly Pro Arg  Pro His Ile Gly Asp  Thr Leu Phe 
    1040                 1045                 1050             


Thr Leu  Phe Arg Ala Pro Glu  Leu Leu Ala Pro Asn  Gly Asp Leu 
    1055                 1060                 1065             


Tyr Asn  Val Phe Ala Trp Ala  Leu Asp Val Leu Ala  Lys Arg Leu 
    1070                 1075                 1080             


Arg Pro  Met His Val Phe Ile  Leu Asp Tyr Asp Gln  Ser Pro Ala 
    1085                 1090                 1095             


Gly Cys  Arg Asp Ala Leu Leu  Gln Leu Thr Ser Gly  Met Val Gln 
    1100                 1105                 1110             


Thr His  Val Thr Thr Pro Gly  Ser Ile Pro Thr Ile  Cys Asp Leu 
    1115                 1120                 1125             


Ala Arg  Thr Phe Ala Arg Glu  Met Gly Glu Ala Asn  
    1130                 1135                 1140 


<210>  89
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  89
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        1497


<210>  90
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  90

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  91
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  91
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  92
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  92

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  93
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dnTGNbRII

<400>  93
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggatgtgg aaatggaggc ccagaaagat      120

gaaatcatct gccccagctg taataggact gcccatccac tgagacatat taataacgac      180

atgatagtca ctgacaacaa cggtgcagtc aagtttccac aactgtgtaa attttgtgat      240

gtgagatttt ccacctgtga caaccagaaa tcctgcatga gcaactgcag catcacctcc      300

atctgtgaga agccacagga agtctgtgtg gctgtatgga gaaagaatga cgagaacata      360

acactagaga cagtttgcca tgaccccaag ctcccctacc atgactttat tctggaagat      420

gctgcttctc caaagtgcat tatgaaggaa aaaaaaaagc ctggtgagac tttcttcatg      480

tgttcctgta gctctgatga gtgcaatgac aacatcatct tctcagaaga atataacacc      540

agcaatcctg acttgttgct agtcatattt caagtgacag gcatcagcct cctgccacca      600

ctgggagttg ccatatctgt catcatcatc ttctactgct accgcgttaa ccggcagcag      660

aagctg                                                                 666


<210>  94
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGNbRII

<400>  94

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu 
    210                 215                 220         


<210>  95
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  95
ggcagcggcg agggcagagg cagcctgctg acctgcggcg acgtggagga gaaccccgga       60

cct                                                                     63


<210>  96
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  96

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  97
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  97
atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc       60

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc      120

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc tcacgggatg      180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac      240

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc      300

tacaccacac aacaccgcct cgaccagggc gagatatcgg ccggggacgc ggcggtggta      360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct      420

cctcatgtcg ggggggaggc tgggagttca catgccccgc ccccggccct caccctcatc      480

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc      540

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc      600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc      660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacggg      720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggtggga ggattgggga      780

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca      840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc      900

aacggcgacc tgtataacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt      960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg     1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca ccccaggctc cataccgacg     1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaacta a              1131


<210>  98
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  98

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  99
<211>  3423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-HSVTK-dnTGFbRII

<400>  99
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgcgga     1500

agcggagcta ctaacttcag cctgctgaag caggctggag acgtggagga gaaccctgga     1560

cctatggctt cgtacccctg ccatcaacac gcgtctgcgt tcgaccaggc tgcgcgttct     1620

cgcggccata gcaaccgacg tacggcgttg cgccctcgcc ggcagcaaga agccacggaa     1680

gtccgcctgg agcagaaaat gcccacgcta ctgcgggttt atatagacgg tcctcacggg     1740

atggggaaaa ccaccaccac gcaactgctg gtggccctgg gttcgcgcga cgatatcgtc     1800

tacgtacccg agccgatgac ttactggcag gtgctggggg cttccgagac aatcgcgaac     1860

atctacacca cacaacaccg cctcgaccag ggcgagatat cggccgggga cgcggcggtg     1920

gtaatgacaa gcgcccagat aacaatgggc atgccttatg ccgtgaccga cgccgttctg     1980

gctcctcatg tcggggggga ggctgggagt tcacatgccc cgcccccggc cctcaccctc     2040

atcttcgacc gccatcccat cgccgccctc ctgtgctacc cggccgcgcg ataccttatg     2100

ggcagcatga ccccccaggc cgtgctggcg ttcgtggccc tcatcccgcc gaccttgccc     2160

ggcacaaaca tcgtgttggg ggcccttccg gaggacagac acatcgaccg cctggccaaa     2220

cgccagcgcc ccggcgagcg gcttgacctg gctatgctgg ccgcgattcg ccgcgtttac     2280

gggctgcttg ccaatacggt gcggtatctg cagggcggcg ggtcgtggtg ggaggattgg     2340

ggacagcttt cggggacggc cgtgccgccc cagggtgccg agccccagag caacgcgggc     2400

ccacgacccc atatcgggga cacgttattt accctgtttc gggcccccga gttgctggcc     2460

cccaacggcg acctgtataa cgtgtttgcc tgggccttgg acgtcttggc caaacgcctc     2520

cgtcccatgc acgtctttat cctggattac gaccaatcgc ccgccggctg ccgggacgcc     2580

ctgctgcaac ttacctccgg gatggtccag acccacgtca ccaccccagg ctccataccg     2640

acgatctgcg acctggcgcg cacgtttgcc cgggagatgg gggaggctaa cggcagcggc     2700

gagggcagag gcagcctgct gacctgcggc gacgtggagg agaaccccgg acctatgggt     2760

cgggggctgc tcaggggcct gtggccgctg cacatcgtcc tgtggacgcg tatcgccagc     2820

acgatcccac cgcacgttca gaagtcggat gtggaaatgg aggcccagaa agatgaaatc     2880

atctgcccca gctgtaatag gactgcccat ccactgagac atattaataa cgacatgata     2940

gtcactgaca acaacggtgc agtcaagttt ccacaactgt gtaaattttg tgatgtgaga     3000

ttttccacct gtgacaacca gaaatcctgc atgagcaact gcagcatcac ctccatctgt     3060

gagaagccac aggaagtctg tgtggctgta tggagaaaga atgacgagaa cataacacta     3120

gagacagttt gccatgaccc caagctcccc taccatgact ttattctgga agatgctgct     3180

tctccaaagt gcattatgaa ggaaaaaaaa aagcctggtg agactttctt catgtgttcc     3240

tgtagctctg atgagtgcaa tgacaacatc atcttctcag aagaatataa caccagcaat     3300

cctgacttgt tgctagtcat atttcaagtg acaggcatca gcctcctgcc accactggga     3360

gttgccatat ctgtcatcat catcttctac tgctaccgcg ttaaccggca gcagaagctg     3420

taa                                                                   3423


<210>  100
<211>  1140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)-HSVTK-dnTGFbRII

<400>  100

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
            500                 505                 510         


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Tyr Pro Cys His 
        515                 520                 525             


Gln His Ala Ser Ala Phe Asp Gln Ala Ala Arg Ser Arg Gly His Ser 
    530                 535                 540                 


Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln Gln Glu Ala Thr Glu 
545                 550                 555                 560 


Val Arg Leu Glu Gln Lys Met Pro Thr Leu Leu Arg Val Tyr Ile Asp 
                565                 570                 575     


Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr Gln Leu Leu Val Ala 
            580                 585                 590         


Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro Glu Pro Met Thr Tyr 
        595                 600                 605             


Trp Gln Val Leu Gly Ala Ser Glu Thr Ile Ala Asn Ile Tyr Thr Thr 
    610                 615                 620                 


Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala Gly Asp Ala Ala Val 
625                 630                 635                 640 


Val Met Thr Ser Ala Gln Ile Thr Met Gly Met Pro Tyr Ala Val Thr 
                645                 650                 655     


Asp Ala Val Leu Ala Pro His Val Gly Gly Glu Ala Gly Ser Ser His 
            660                 665                 670         


Ala Pro Pro Pro Ala Leu Thr Leu Ile Phe Asp Arg His Pro Ile Ala 
        675                 680                 685             


Ala Leu Leu Cys Tyr Pro Ala Ala Arg Tyr Leu Met Gly Ser Met Thr 
    690                 695                 700                 


Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile Pro Pro Thr Leu Pro 
705                 710                 715                 720 


Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu Asp Arg His Ile Asp 
                725                 730                 735     


Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg Leu Asp Leu Ala Met 
            740                 745                 750         


Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu Leu Ala Asn Thr Val Arg 
        755                 760                 765             


Tyr Leu Gln Gly Gly Gly Ser Trp Trp Glu Asp Trp Gly Gln Leu Ser 
    770                 775                 780                 


Gly Thr Ala Val Pro Pro Gln Gly Ala Glu Pro Gln Ser Asn Ala Gly 
785                 790                 795                 800 


Pro Arg Pro His Ile Gly Asp Thr Leu Phe Thr Leu Phe Arg Ala Pro 
                805                 810                 815     


Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr Asn Val Phe Ala Trp Ala 
            820                 825                 830         


Leu Asp Val Leu Ala Lys Arg Leu Arg Pro Met His Val Phe Ile Leu 
        835                 840                 845             


Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg Asp Ala Leu Leu Gln Leu 
    850                 855                 860                 


Thr Ser Gly Met Val Gln Thr His Val Thr Thr Pro Gly Ser Ile Pro 
865                 870                 875                 880 


Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala Arg Glu Met Gly Glu Ala 
                885                 890                 895     


Asn Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
            900                 905                 910         


Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp 
        915                 920                 925             


Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro 
    930                 935                 940                 


His Val Gln Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Glu Ile 
945                 950                 955                 960 


Ile Cys Pro Ser Cys Asn Arg Thr Ala His Pro Leu Arg His Ile Asn 
                965                 970                 975     


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
            980                 985                 990         


Leu Cys Lys Phe Cys Asp Val Arg  Phe Ser Thr Cys Asp  Asn Gln Lys 
        995                 1000                 1005             


Ser Cys  Met Ser Asn Cys Ser  Ile Thr Ser Ile Cys  Glu Lys Pro 
    1010                 1015                 1020             


Gln Glu  Val Cys Val Ala Val  Trp Arg Lys Asn Asp  Glu Asn Ile 
    1025                 1030                 1035             


Thr Leu  Glu Thr Val Cys His  Asp Pro Lys Leu Pro  Tyr His Asp 
    1040                 1045                 1050             


Phe Ile  Leu Glu Asp Ala Ala  Ser Pro Lys Cys Ile  Met Lys Glu 
    1055                 1060                 1065             


Lys Lys  Lys Pro Gly Glu Thr  Phe Phe Met Cys Ser  Cys Ser Ser 
    1070                 1075                 1080             


Asp Glu  Cys Asn Asp Asn Ile  Ile Phe Ser Glu Glu  Tyr Asn Thr 
    1085                 1090                 1095             


Ser Asn  Pro Asp Leu Leu Leu  Val Ile Phe Gln Val  Thr Gly Ile 
    1100                 1105                 1110             


Ser Leu  Leu Pro Pro Leu Gly  Val Ala Ile Ser Val  Ile Ile Ile 
    1115                 1120                 1125             


Phe Tyr  Cys Tyr Arg Val Asn  Arg Gln Gln Lys Leu  
    1130                 1135                 1140 


<210>  101
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  101
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acgtgctgat gacacagagc cctctgagcc tgcctgtgac acctggcgaa      120

cctgccagca tcagctgcag atccagccgg aacatcgtgc acatcaacgg cgacacctac      180

ctggaatggt atctgcagaa gcccggccag tctcctcagc tgctgatcta caaggtgtcc      240

aaccggttca gcggcgtgcc cgatagattt tctggcagcg gctctggcac cgacttcacc      300

ctgaagatct ccagagtgga agccgaggac gtgggcgtgt actactgctt ccaaggctct      360

ctgctgccct ggacatttgg ccagggcacc aaggtggaaa tcaagggagg aggtggatca      420

ggtggaggtg gaagcggggg aggaggttcc ggcggcggag gatcagaagt tcagctggtt      480

gagtctggcg gcgacctggt tcagcctggc agatctctga gactgagctg tgccgccagc      540

ggcttcatct tcagcaacta cggcatgagc tgggtccgac aggcccctgg aaaaggactg      600

gaatgggtcg ccacaatcag cagcgccagc acctacagct actaccccga tagcgtgaag      660

ggcagattca ccatcagccg ggacaacgcc aagaacagcc tgtacctgca gatgaactcc      720

ctgcgcgtgg aagatacagc cctgtactat tgcggcagac acagcgacgg caacttcgcc      780

tttggctatt ggggccaggg aaccctggtc accgtttcta gttccggaac cacgacgcca      840

gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca      900

gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt      960

gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1020

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1080

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1140

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        1497


<210>  102
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H)

<400>  102

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Arg Asn Ile Val His Ile Asn Gly Asp Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser Leu Leu Pro Trp Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr Gly Met Ser Trp Val 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser 
        195                 200                 205             


Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys Gly Arg His Ser Asp 
                245                 250                 255     


Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  103
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  103
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  104
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  104

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  105
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  105
atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc       60

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc      120

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc tcacgggatg      180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac      240

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc      300

tacaccacac aacaccgcct cgaccagggc gagatatcgg ccggggacgc ggcggtggta      360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct      420

cctcatgtcg ggggggaggc tgggagttca catgccccgc ccccggccct caccctcatc      480

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc      540

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc      600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc      660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacggg      720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggtggga ggattgggga      780

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca      840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc      900

aacggcgacc tgtataacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt      960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg     1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca ccccaggctc cataccgacg     1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaac                  1128


<210>  106
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSVTK

<400>  106

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  107
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  107
ggcagcggcg agggcagagg cagcctgctg acctgcggcg acgtggagga gaaccccgga       60

cct                                                                     63


<210>  108
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  108

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  109
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dnTGNbRII

<400>  109
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggatgtgg aaatggaggc ccagaaagat      120

gaaatcatct gccccagctg taataggact gcccatccac tgagacatat taataacgac      180

atgatagtca ctgacaacaa cggtgcagtc aagtttccac aactgtgtaa attttgtgat      240

gtgagatttt ccacctgtga caaccagaaa tcctgcatga gcaactgcag catcacctcc      300

atctgtgaga agccacagga agtctgtgtg gctgtatgga gaaagaatga cgagaacata      360

acactagaga cagtttgcca tgaccccaag ctcccctacc atgactttat tctggaagat      420

gctgcttctc caaagtgcat tatgaaggaa aaaaaaaagc ctggtgagac tttcttcatg      480

tgttcctgta gctctgatga gtgcaatgac aacatcatct tctcagaaga atataacacc      540

agcaatcctg acttgttgct agtcatattt caagtgacag gcatcagcct cctgccacca      600

ctgggagttg ccatatctgt catcatcatc ttctactgct accgcgttaa ccggcagcag      660

aagctgtaa                                                              669


<210>  110
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGNbRII

<400>  110

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu 
    210                 215                 220         


<210>  111
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) VH chain

<400>  111
gaagttcagc tggttgagtc tggcggcgac ctggttcagc ctggcagatc tctgagactg       60

agctgtgccg ccagcggctt catcttcagc aactacggca tgagctgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtcgccaca atcagcagcg ccagcaccta cagctactac      180

cccgatagcg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga actccctgcg cgtggaagat acagccctgt actattgcgg cagacacagc      300

gacggcaact tcgcctttgg ctattggggc cagggaaccc tggtcaccgt ttctagt         357


<210>  112
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) VH chain

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Gly Arg His Ser Asp Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  113
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) VL chain

<400>  113
gacgtgctga tgacacagag ccctctgagc ctgcctgtga cacctggcga acctgccagc       60

atcagctgca gatccagccg gaacatcgtg cacatcaacg gcgacaccta cctggaatgg      120

tatctgcaga agcccggcca gtctcctcag ctgctgatct acaaggtgtc caaccggttc      180

agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc      240

tccagagtgg aagccgagga cgtgggcgtg tactactgct tccaaggctc tctgctgccc      300

tggacatttg gccagggcac caaggtggaa atcaag                                336


<210>  114
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4(KW_L2H) VL chain

<400>  114

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Asn Ile Val His Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Leu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Sequence repeats N times, where N = an integer of at least 1.

<400>  115

Gly Ser Gly Gly Ser 
1               5   


<210>  116
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  Sequence repeats N times, where N = an integer of at least 1.

<400>  116

Gly Gly Gly Ser 
1               


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Sequence repeats N times, where N = an integer of at least 1.

<400>  117

Gly Gly Gly Gly Ser 
1               5   


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  118

Gly Gly Ser Gly 
1               


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  119

Gly Gly Ser Gly Gly 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  120

Gly Ser Gly Ser Gly 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  121

Gly Ser Gly Gly Gly 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  122

Gly Gly Gly Ser Gly 
1               5   


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  123

Gly Ser Ser Ser Gly 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  124

Gly Gly Gly Gly Ser 
1               5   


<210>  125
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  125

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  126
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  126
ggaggaggtg gatcaggtgg aggtggaagc gggggaggag gttccggcgg cggaggatca       60


<210>  127
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any naturally occurring amino acid

<400>  127

Arg Xaa Lys Arg 
1               


<210>  128
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any naturally occurring amino acid

<400>  128

Arg Xaa Arg Arg 
1               


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any naturally occuring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Lys or Arg

<400>  129

Xaa Arg Xaa Xaa Arg 
1               5   


<210>  130
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any naturally occurring amino acid

<400>  130

Arg Xaa Xaa Arg 
1               


<210>  131
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site

<400>  131

Arg Gln Lys Arg 
1               


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  132

Asp Lys Thr His Thr 
1               5   


<210>  133
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  133

Cys Pro Pro Cys 
1               


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  134

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  135

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  136

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  137

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  138

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  139
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  139

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  140

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  141
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  141

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  142
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  142

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  143

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  144
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sh-CCR4#1

<400>  144
gaaugaaguu guagguaaua ucugugaagc cacagauggg auauuaccua caacuucauu       60

cuuuuuu                                                                 67


<210>  145
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sh-CCR4#2

<400>  145
gcaugaguca gucugaugag acugugaagc cacagauggg ucucaucaga cugacucaug       60

cuuuuuu                                                                 67


<210>  146
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sh-CCR4#3

<400>  146
gcugauggag uaaaucgcua ccugugaagc cacagauggg guagcgauuu acuccaucag       60

cuuuuuu                                                                 67


<210>  147
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sh-CCR4#4

<400>  147
guuguaggua auauugcaag gcugugaagc cacagauggg ccuugcaaua uuaccuacaa       60

cuuuuuu                                                                 67


<210>  148
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sh-Cre

<400>  148
gauuuacggc gcuaaggaug acugugaagc cacagauggg ucauccuuag cgccguaaau       60

cuuuuuu                                                                 67


<210>  149
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding sh-CCR4#1

<400>  149
gaatgaagtt gtaggtaata tctgtgaagc cacagatggg atattaccta caacttcatt       60

ctttttt                                                                 67


<210>  150
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding sh-CCR4#2

<400>  150
gcatgagtca gtctgatgag actgtgaagc cacagatggg tctcatcaga ctgactcatg       60

ctttttt                                                                 67


<210>  151
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding sh-CCR4#3

<400>  151
gctgatggag taaatcgcta cctgtgaagc cacagatggg gtagcgattt actccatcag       60

ctttttt                                                                 67


<210>  152
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding sh-CCR4#4

<400>  152
gttgtaggta atattgcaag gctgtgaagc cacagatggg ccttgcaata ttacctacaa       60

ctttttt                                                                 67


<210>  153
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding sh-Cre

<400>  153
gatttacggc gctaaggatg actgtgaagc cacagatggg tcatccttag cgccgtaaat       60

ctttttt                                                                 67


