                         SEQUENCE LISTING

<110>  UNIVERSITY OF VIRGINIA PATENT FOUNDATION
       THE REGENTS OF THE UNIVERSITY OF COLORADO
       ZIMRING, JAMES C.
       D'ALESSANDRO, ANGELO C.
 
<120>  USE OF BILIVERDIN REDUCTASE B INHIBITORS TO ALLOW MALARIA 
       ERADICATION IN PATIENTS WITH G6PD DEFICIENCY

<130>  3062/107/2 PCT

<150>  US 63/147,438
<151>  2021-02-09

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  799
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(678)

<400>  1
agtgggttcc cgcgcgtgcc gagactctga ggccttgcac ccccacgatc ccgtacg          57

atg gcc gtc aag aag atc gcg atc ttc ggc gcc act ggc cag acc ggg        105
Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly           
1               5                   10                  15                

ctc acc acc ctg gcg cag gcg gtg caa gca ggt tac gaa gtg aca gtg        153
Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val           
            20                  25                  30                    

ctg gtg cgg gac tcc tcc agg ctg cca tca gag ggg ccc cgg ccg gcc        201
Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala           
        35                  40                  45                        

cac gtg gta gtg gga gat gtt ctg cag gca gcc gat gtg gac aag acc        249
His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr           
    50                  55                  60                            

gtg gct ggg cag gac gct gtc atc gtg ctg ctg ggc acc cgc aat gac        297
Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp           
65                  70                  75                  80            

ctc agt ccc acg aca gtg atg tcc gag ggc gcc cgg aac att gtg gca        345
Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala           
                85                  90                  95                

gcc atg aag gct cat ggt gtg gac aag gtc gtg gcc tgc acc tcg gct        393
Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala           
            100                 105                 110                   

ttc ctg ctc tgg gac cct acc aag gtg ccc cca cga ctg cag gct gtg        441
Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val           
        115                 120                 125                       

act gat gac cac atc cgg atg cac aag gtg ctg cgg gaa tca ggc ctg        489
Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu           
    130                 135                 140                           

aag tac gtg gct gtg atg ccg cca cac ata gga gac cag cca cta act        537
Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr           
145                 150                 155                 160           

ggg gcg tac aca gtg acc ctg gat gga cga ggg ccc tca agg gtc atc        585
Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile           
                165                 170                 175               

tcc aaa cat gac ctg ggc cat ttc atg ctg cgc tgc ctc acc acc gat        633
Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp           
            180                 185                 190                   

gag tac gac gga cac agc acc tac ccc tcc cac cag tac cag tag            678
Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln                   
        195                 200                 205                       

cactctgtcc ccatctggga gggtggcatt ctgggacatg aggagcaaag gaagggggca      738

ataaatgttg agccaagagc ttcaaattac tctagagaaa ccgactgtgt gactcttcct      798

c                                                                      799


<210>  2
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala 
            100                 105                 110         


Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val 
        115                 120                 125             


Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu 
    130                 135                 140                 


Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr 
145                 150                 155                 160 


Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile 
                165                 170                 175     


Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp 
            180                 185                 190         


Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln 
        195                 200                 205     


<210>  3
<211>  17978
<212>  DNA
<213>  Homo sapiens

<400>  3
agtgggttcc cgcgcgtgcc gagactctga ggccttgcac ccccacgatc ccgtacgatg       60

gccgtcaaga agatcgcgat cttcggcgcc actggccaga ccgggctcac caccctggcg      120

caggcggtgc aagcaggcat gagccggggc gggcggggca tgtcacggga cagacgggca      180

gaactttagg aaggggcacc atggggtcgg gccgaggctg attggggcca tgagcgcccc      240

agccaggtgt atgaggactc aggggccaaa gcaagtggcc acgggggcag aaatggggaa      300

agatgtgaga tccaagttta tgtgagtcca agccagagag gaattggccc cgggagcccc      360

gggaggactc cactggcaca gtcgtgtgta agtccagggc tcttatgcaa tgcggttgtc      420

attattgtgg ttgtggtggt ggttgttcgc actcccagag aggatttact aagccaagct      480

tgctctgtcg tctcttcaca tgagagcttt caaaatgggg tgggaactag tatcacccta      540

cttgacagat gagaaaactg agacccagag agtgacttgc ccaatatcac acagctgtta      600

actgacagga ctgggatttg aactcagctc atgctcttaa ccaccacaag tccccaggct      660

ggaaactgaa aaagttgggg ggtcaggttg ctgcgagtac ctaatgggaa ggagtcacag      720

agagacatga gtgaagactt ggggacagca gtcctgggaa agtcaatgag ggctgaaaat      780

ttggagttgc cccaggagag agggcagaaa aggggataac catcccccag cactccctgc      840

ccccacagcc cagacttgac caactcccag ctgggcctgg gacttccaga tatggggccc      900

cacccttgca ggccttgggg acgctgaaga tattgactat ctgcgtgccc caaaagggtg      960

gaggccaaca ggaccccact ctgctgtctc ccttggaggg actctgaaag ttcttctcta     1020

ggtccataac tctccccttc cccagggaga ccacgtgagg atcttgactt gtggagaatg     1080

gggagctgtg ggcctctcag taaaaaccag tttgctgata agcatttatt cgggagtaat     1140

ggagaaggaa gtaagagaga gaagttgaga ggcgctgagt cacctggaaa tccactaatt     1200

ccaccgaatt ccactcgccc accctgctgg tcatagctgg gactgcactc agagggttaa     1260

gaactggagc ctagggagct tcagagctgt ggctctgaaa aatctcttcc cagctctcag     1320

ctttgctgtc cccctcagca aagggaaggg ctggccaggc acggtggatc atgcctataa     1380

tcccagcact ttgggaggcc aaggcgggag gatggcttga ggccaggagt ttgagactag     1440

cctgggcaac gtagcaagac cccatctcta caaaaataca aaaaaaaaat aaattagctg     1500

ggcgtggtga tgcatgcctg tagtcccagc tactcagaag gctcaggtgg gaggattgct     1560

tgagctcagg agttcaaggc tacagtgagc tgtgtttgca ccactgcact ccagcctggg     1620

tgacagggtg agaccctgtc tctcaaattt aaaaaaatac ataaaaagaa agaaaaagag     1680

gctgggtgcg gtggctcacg cctgtaatct cagcactttg ggaggctgag gcaggtggat     1740

cacgaggtca ggagttcgag accagcctgg ccaatatagt gaaaccccgt ctctactaaa     1800

aatacgaaaa attagccggg catggtggct ggtgcctgta atcgcagtta cttggcagac     1860

tgaggcagga gaatagcttg aatccgggag gcagaggttg tggtgagccg agattacgcc     1920

actgcattcc agcctgggcg acaagagtga aactctgtct caaaaaaaaa aaaattagct     1980

gggcacagtg gtacgtgcct gtaattccag gtacttggga ggctgaggca caagaatcgc     2040

ttgaacctgg gaggttgcag tgagctaaga ttgcatcact gcaccactgc actccagcct     2100

gggtgacaca gcaagatgaa aggaaagaag gaaggaagaa aaggagggag ggatggaggg     2160

agggagggag ggaaggaaag aagggaggga aggagggagg gagggaggga gggagggaga     2220

aggggcttgg attaactgga gttcacaatg gttctgtagg gccaagagtc ttaacaggca     2280

tgaactctgg tgccagcctg cccacattca agtcaccagc tctgcggctt acagcctttg     2340

tgaccaaatg ccttgtcatc tgtgtaccta gatatgtgta agatcatgac aaaactggta     2400

gtacttgccc tagggctctt gggataatta aatgagatct tatataggag gtacttagac     2460

tagcattgaa ttttgcagtc tctggatcag acttacttag gtaaaaattc aaccttctct     2520

acctactagc tgtgtgatcc tggcccggtt gcctaaaatt gcctcagttt ccccatcaat     2580

gtggacagga taatgatacc taccttgcag ggttgttgca acctgatgct tctcaaactg     2640

tgagttacaa tgagatctga aacatatggt cacaacgtgt atcaacaata tagggtaaca     2700

aatgatgaca tagtatcaaa atgtatcaca tgttaagtat tagttttgtg aaactcattt     2760

taattatata tgtatgcgtt tgtgtacacc aggttaggca atgaaatttt ttgtattgat     2820

ggctgatttt tttttttttt tttttttttt tttgagacaa gagtctcact ctgccgccca     2880

ggctggagtg cagtggcaca atcttagctc actgcaagct ccgcctcccg agttcagcca     2940

ttctcctgct tcagcctccc aagtagctgg gactacaggc gcctgccacc atgcccagct     3000

aatttttttt gtatttttag taaagatggg gtttcaccat gttaaccagg atggtctcca     3060

tctcctgacc tcatgatccg cccgcctcag cctcccaaag tgctgggatt acaggcgtga     3120

gccaccacgc ccggccaatg gctgagattt tcaaaaagct taaaaagagg ccaggcacca     3180

tggctcacgc ctgtaatccc agcactttgg gaggccaagg tgggcggatc acaaggtcag     3240

gagatcgaga ccaccctggc taacaccgtg aaaccccatc tctactaaaa atacaaaaaa     3300

ttcgccgggt gttgtggtgc acacctataa tcccagctac tctggaggct gaggtgggag     3360

aatcgcttga acctgggagg cggaggttgc agtgagctga gattgcgcca ctgcactcca     3420

gcctgggcaa gagagtgaga cttcatctca aaaaaaaaaa aaaaaagaat gcccatattg     3480

gcccatgcaa gcccctgctg ctcccccatg tgtgagggca gcacagatct tgtgtcattc     3540

ccctatgaaa ggtggtcaca tagcacgggg aggctggtgc tgtgatcctc acttcagaga     3600

tgaggaagct gaggtccaat cacggaagag gttgcatgag gttcctcagc tggtaagtgg     3660

cagagctgga gtttggatca aggtccctgg ggcagtaatg cctgtgcttt tgtgtttaca     3720

aaggttcagg gagatggcag aaaacatgac acagtccctg gacccacagg gtgcttggtt     3780

tgctgcaggt cagcataaag agggctgtga cagaggaagt acaagttact ggggggaccg     3840

ggtaaagagg gtaaagggtg ttccaggcag agggcacagc acgtgcaaag tccaggaggc     3900

aggaagcagc accatgcatt tgaggaactg aaagaagagc agttggggcc gggtgcagtg     3960

gctcatgcct gtaatcccaa cactttgggg ggctgaggca ggtggatcac acagtcagga     4020

gttcgagacc agcctggcta acatcgtgaa accccatctc tactaaaaat acaaaaaaat     4080

tagccaggca tggtggcagg cgcctgtaat cacagctact caggaggctg aggcaggaga     4140

atcgcttgaa cccatgagac ggaggttgca gtgagccgag actgcaccac tgcactccag     4200

actgggcaac agagcgagac tccgtctcag aaaaaaaaaa aaaaaaatgt gctgtgggtg     4260

aagagggcag aggcttcagc agagcctgga gaggagaagc cagatcccga ggggcctgga     4320

aggctggcat gaggagcatg ggttttatca cagggcattt caggcttgcg ggaggcaact     4380

gagcagagag gcacttaaat attactgtgg agaactctgt ctggctgctg tgtggaatat     4440

ggattggaga gggcaggact gggtccagga gcccagggag gacccaggaa agggaccagg     4500

aaggagacgt aggcctggat caggccagga gataaagttg caaaatggtt acaaggtgta     4560

ataggccacg ctcggtagct catgcctgta atcccagcac tttgggaggc catgccaggc     4620

agattacttg agtccaggag ttcgagacca gcctggccaa catgcaaaac cccatctctt     4680

tttttaattt ttttattgtg tctttttggg ttttttggtt ttttatgttt attgttgttg     4740

ttgttgtttg ttttgttttg ttttgttttg tttgagacgg agtttcgctc ttgttgccca     4800

ggctggcgtg caatggcaca atctcagctg actgcaatct ctacctcctg ggttcaagcg     4860

attcttctgc ctcagcctcc caagtagctg ggattacagg catgcaccac catgcctggc     4920

taattttgta tttttagtag aggcggggtt tccctgtgtt ggtcaggctg gtcttggact     4980

tccaacttca ggtgatccac ctgccttggc ctcccaaagt gctgggatta caggcgtgag     5040

ccatcgcgcc cagcaccagg taactcttat ttctgtgcca ggtagtagcc taaacttttt     5100

gttaatttaa tttaatttaa tttaatttaa tttatttatt tatttttgag acagagtctt     5160

gttctgtagc ccaggctgga gtgcagtggt acaatcatag ctcactacag cctcagccac     5220

ctgagtagct gagactacag gttgcgccag cacacctggc tagatttttt ttattttttt     5280

tgcagagacg gggtttcact atgttgccca gtctggtctc aaactcctgg cctcaaacaa     5340

tcttcctgtc ttggcctccc aaagcactgg gattataata ggcatcagcc caggaatttg     5400

aggttacagt gagctatgat tggcgcccct gcactccagc ctgggcaaca gagcaagacc     5460

ctgtctctaa atatatatat atatatatat atatatatgt tgctattaca gtatacccaa     5520

atgttaacat cctttgccaa tgtttaaaac aaaggaagaa atatgttagt tgtgaacttt     5580

aaaatgtgtg tgtatgtgtg tgtgtgttga agagaaacaa aattatccaa aattattttg     5640

ggaaggaaca tactaagaca atattaaaaa tctttaatga ccactaaagg agggctgggc     5700

ttcccagcag taaggctggg cagcaggggc tgggaccaat cccagcactg gtcagtctgt     5760

aggcaaccca tgtccccctc agaacctcag tttcttccag gaccatggat gggagacaga     5820

gaccagtgca atgcctgcat taacccttta gttgttagag ggtagggaag ttgctggctg     5880

ggtacagtgg cttacgcctg taatcctagc actttgggag gccaaggtgg gtggatcacc     5940

tgaggttagg agttcaagac cagcctggcc aacatggtaa aaccctatct ctactagaaa     6000

cacaaaaatt agttggatgt ggtggcatgc gcctgtagtc ccagctactc gggaggctga     6060

ggcaaaagaa tcgcttgaac ttgggaggcg gaggttgcag tgagctgaga tcatgccact     6120

gtgctccagc ctgggcaaca gagggagact ctatctcaaa aaaaataata atgatagcca     6180

ggtgtggtgg cacgtgcctg aacccgggag gcggaggttg cagtgagccg agattgtgcc     6240

actgcactct agcctgggtt acagagtgag attccgtctc aaaaaataat aataataata     6300

aatagaaggt aaggaattta cagggtgtgg tgcttggagg cttcagttca gattatttat     6360

gaattatcat gaaggtatgg tctttttttt tttttttttt tttttttttt ttttttttga     6420

gatagagtct cgctttgtca tccaggctgg agtgcactgg tgcaatctct gctcactgca     6480

acctccgcct gtcgggtcaa gtgattcttt tgcctcagct tcccaagtac ttgggattac     6540

aggtatgtgc caccatgcct ggctaatttt gtatttttag tggcaatggg gtttcatcat     6600

gttgtccagg ctggtctcaa actcctgacc tcaggtgatc tgcccgcctc agcctcccaa     6660

agtgttgaga ttacaggcgt gagccaccat gcctggccaa ggtatggtct attttaataa     6720

tcagcccaat actaagcatc aactgtaggt atgccagcaa aaatgtttga aggccacggc     6780

gcagtggctc atggggaggc tgaggcaggc agatcacctg agcccaggag ttcaagacca     6840

gcctgggcaa catggcaaaa ccccttctct acaaaagatt gcaaaattag ctgggtgtgg     6900

tggtgcacac tgtggtccca gctacttggg gtgctgagat gggaggatca gttgaacccc     6960

ggaggttgag gctgcagtga gctgtgactg caccattgca cagcagcctg ggcaagtgag     7020

caagaccctg tctcaaaaac aaaacaaaca aaaagaaaaa accaaaaatg tttgaagacc     7080

acttccccag aacagaggag gggatggatt tgagagttca tggtggcttc taggacccag     7140

ctcctggagc ccaagagtgc cagcccactg accaggctct ctgctcctct ttgcccacag     7200

gttacgaagt gacagtgctg gtgcgggact cctccaggct gccatcagag gggccccggc     7260

cggcccacgt ggtagtggga gatgttctgc aggcagccga tgtggacaag accgtggctg     7320

ggcaggacgc tgtcatcgtg ctgctgggca cccgcaatga cctcagtact gagccccccc     7380

tctgcccacg gccctcccct acacctcggc ccccagcgcc acccccgccc ccggccccgc     7440

ccctgccacc cctgccgccg ccgccgccca ccagtgacag ccactctctg tcccctctaa     7500

ggtcccacga cagtgatgtc cgagggcgcc cggaacattg tggcagccat gaaggctcat     7560

ggtgtggaca aggtcgtggc ctgcacctcg ggtgggtggt gggatcatgg aggtggggct     7620

gaactggggg gtactgggga ggcagcccag gggcctctga aaggtgacgc tgaagccatt     7680

ccatgttact gtgcatttac tgaacaccag ctgtgtgcct gaaccttact gggtgatgct     7740

ggggacacag tggtgacctg tacagccctg ggccctgctc acacaaggct cacagagaga     7800

ggtggtaaac agatccatga tcaaactgac atccagatca tcggagctgg gatcgggagg     7860

caggcagagg ggatagggcc acaatgggag aaactacagg actatgggag cccagaggag     7920

gcgtccgact taggctgaga gaggtcaggg taggcctccc agaggaagtg atagagctgt     7980

ggatagacac taggtctctg ccctcacaga gctcccgatt atggggacac agacattaag     8040

caaatagttg ccctgtataa tcatttattt atttatttat ttatttatag ttattttgag     8100

gtttgtttga gatagagtct tgctctgatg cccaggctgg agtgcagtgg cgtgatcttg     8160

gctccctgca acctccgcct cccggaggtg gttctcctgc ctcaagtgat tctcctgcct     8220

ctgcctccca ggtagctggg actacaggtg tgcaccacca tgcccagcta atttttgtat     8280

ttttagtaga gacagggttt cgccatgttg gccaggctag tctcgaactc ctgacctcaa     8340

gtgtgtttca tgacacaaat tgcctccctg gaaagggaag tggcatgagg gagggctgcc     8400

tgatgattgt aattacactc caggcagagg acaaagcaag caaagaggcc tggaggccag     8460

acctagttgg agggtaggaa gcaaaatcat ttatggcttt tttcctcaag ctctgaaatg     8520

gaaaagtaat acacgagtaa acttgcgatt tcagaatggt tcactttttt tttttttttt     8580

tgagactttc tgtcacccag gctggagtgc agtggtgcaa ccatggctca ctgcagcctc     8640

agtctgggtt caagtgatcc tccccactgc agcctcccaa gcggctggga ctacaggcat     8700

gcaccaccac acctggctaa ttttttgata tttttgtaga gacaaggtct tacttttgtt     8760

cgcagattgg aatggtctgc tgttaatttt agttttgttt ttttctccca tgtctttttt     8820

tctttgagat gaagtctgac tccattgccc aggctggagt gcagtggcgt ggtatcagct     8880

cactgcaacc gccactccac ctcccgggtt catggtgcct gggaccaaga tcgtggccca     8940

cagtgattct cctgccccag cctcctgagt agctgggatt accggcgcct gccaccatgc     9000

cctgctaatt tttgtatttt tggtagagac aaggttttgc catgttggcc aggctgatgt     9060

tgaactcctg gcctcaagca gtcctcccac ctcagccttc caaagtgctg agattacagg     9120

tataagccac cacgtccaga ctctcccatg tcttaaaaac caatttaact ggttaagttt     9180

tgcttccatg aaaaagacaa acctgtaaaa ttgatttaat ttgctttctt ttttctcatt     9240

tttttttgtt tagattgttt tctaaatatt aaagtcttag gtgtgccagg attttttttt     9300

tcattaaaaa aaaaacaaac atagagacaa ggtctcgctc tgtcacccag gctggagtgc     9360

agtggcctga tcatagctca ttgtaccctt gaacccctgg gctcaaggaa tcccctcact     9420

ttagcccctc aaatagctgg ggcaacaggt atgagccatt gagtccagct taacttttta     9480

tctggaaatg atcttaaact tacagaaaaa ttgaaaggac accagtacac ctaccgtcct     9540

ctgttcacag acacacaatg ttttttttct gacccatttg aagttagctt acatacatca     9600

tggctgctta cttcaatgtg taggtcctca atatactttt taacttttta ttataaaaat     9660

ttttaaacag aaaagttaat agtcgtgtga acaaccatat tccttttctt tttttatttt     9720

taagtttgta gctatctatc tatttattta tttattttga gaccgggtta taaggctggc     9780

taatttttgt atttttggta gagatagagt ttcgccatgt tgcccaggct ggtcccgaac     9840

tcccggactc aagcgatcca ccagcctcag cctcccaaag tgctgggatt acacctgagc     9900

cactgcacct ggccaacagc catattcctg attttaaaat tgtgattgtg ttttgtaatt     9960

ggtttatcta tgcacataca catacacaaa tagattttgt ttttgttctc ctaaactatt    10020

tgggtttttt gtttgtttgt ttttatttga gacagagtct cattctgtca cccaggccgg    10080

aatacagtgg cgtgatcttg gctcactgca acatccacct cctgggttca agggattctc    10140

ctgcctcagc ctcctgagta gctgggatta caggtgcctg ccaccacatc tggttaattt    10200

tgtgtgtgtg tatttttagt atagatgggg tttcaccata ttgggcaggc tggtctgacc    10260

tcaagtgatc tggcctccca aagtgctgga ttacaggcat gagccactgc gcccagactt    10320

cctaaactat ttgaaatgga gttgcacacc cacagacacc ttcggcaagt cccaagaaaa    10380

aggacttttc tcttccagca ccacagtgct attgtcacac tttaattatc ttccagcctc    10440

taattattag agtttaatct tccctccata ttcaaatgtc aaggtaaaag attagaaaga    10500

tttttgtcat ctaaggagct tggagtttat ccattagggc ttggggagga ttgtttttta    10560

tggaggcatc tgagaggatt agaaagaaac ccagagtaag gccaggcaca gtggctcacg    10620

cctgtaatcc tagcactttg agaggccaag gtgggcggat tgcttgcgtc caggagtgca    10680

ggaccagtct gggcaacaca gcaaaactcc atctctacaa aaaaaaaata caaaaaatta    10740

gctgggtgtg gtggtacaca cctgtggtcc ccaatacttg ggaagcttag gtaggaggat    10800

cctttgagcc tagaaggcag aggttgcagt gagccgtgat ggcaccactg cactccagcc    10860

ttggctgcag agcaagaccc tgtctcaaaa cacaacaaaa cagccgggtg ctgtggctca    10920

cgcctgtaat cccagcactt tgggaggcca aggtgggtgg atcacgaggt caggagattg    10980

agaccatcct ggctaacaca gtgaaacacc gtctctacta aaaatacaaa aaattagcca    11040

ggcgtggcgg cgggtgccta tagtcccagc tactcgggag gctgaggcag gagaatggcg    11100

taaacccggg aggaggagct tgcagtgagc tgagatcgtg ccactgcact ccagcctggg    11160

tgacagagcg agactgcctc aaaaaaaaaa agaaaaaaga aactaggggt aagttagaga    11220

ctggatttga gattgtgaac tggagactgg aggctgcaga caaaaaccca cttcacactc    11280

tgcaccgcag ttttctcatc tgtaaagagg aaatcctaga ccaggcgcag tggctcacgc    11340

tgtaatccca gcactttagg aggctaaggc aggtggatcg cttgaggtca ggagttcgag    11400

accagcctgg ccaacatggt gaaaccccgt ctctaccaaa aatacaaaaa ctagccaggt    11460

gtggtggcac acgcctgtaa tcccagctac tcaggaggct taggcaggag aatcacttga    11520

aacttgtagg tggaggttgc agtgagaatg atgtcatcat agctcgctac cgcctccaac    11580

tcctaggctc aagggatcct cctgagtagc tgagaccaca ggcatgtgcc accatgccca    11640

tctaattttt aaaatttttt tgttgcgaca gagtctggct ttgttgccca ggctggtctc    11700

tgtgacacac ctttttataa ccactaacat tactcaaact atttatttat ttctttttgt    11760

tgagacaagg tcttgctctg ttgtccaggc tggagtgcag cggtgcaatc acagctcact    11820

gcagcctcga actcctgagc tcaagcgatc ctctcgcctc agccttctaa gcagctaaga    11880

ccacaggtcc ccacgcctgg ctaatttttt aattttctgt agagacaggt ctcaccatcg    11940

tacccaggtg agtctagaac tgctgggctc aactgatcct cctacctcag cctcccaaag    12000

tgctgggatt acaggtgtga gccactctgc ccagcctttg aacaatttat atcatcccag    12060

tttgcacatg aggaaacaag aagctggcca gtggtcgatc cagtacttga ctttaggcaa    12120

aacccaagct ctttaactat tcaccaaact gctcctaaaa atatttagca tagttcttgg    12180

cttgaggtaa aagttctata aatgtcagct ggtgtagctt ggccaagtta tagcttgttg    12240

aaagctaatt cctgaacaaa tatttagtaa gtacctacaa tgttccagat gcttctaagg    12300

gctgggattg gagcaggaaa tgtgatagag tcacaggata actctagcgt gtggtggcag    12360

gggaagggtc ctagggagaa aacaaggccc caagaaaagg gattggtaaa ctgggctggg    12420

ggagacagga ttttgcaatt ttaaacagga cagtcaagaa aagctgcatg gaaaggtgac    12480

ctttgagcaa agtctgcaaa gaaaacaggg agccatgtgg ctacgagagg gaaatggcaa    12540

agggtcctgg gtcacacctg taatcgcagc attttaggag gtcgagatgg aaggatcgct    12600

taagcccggg agttcaaaac tagcctgggc aacttggtaa gacctccatc gctacaaaaa    12660

aaatgttttt ttctttttct tttgagacgg agtcttgctc tgtcacccag gctggagtgc    12720

aatggcacga tctcggctca ctgcaacctc tgcctcccag gttcaaggga ttctcctgcc    12780

tcagcttcct gagaatagct gggattacag gcatgcacca cgacacctgg ctaatttttg    12840

tgtttttttt gttttgtttt gttttgttct gctttgtttt tgagatggag tcttgctctg    12900

tctcccaagc tggagtgccg tggcgcgatc tcagctcact gcaacctccg cctcaagggt    12960

tccagcaatt ctccagcttc agcctcctga gtagctagga ctacaggcat gcaccaccat    13020

gcccagctaa cttttgtatt tttactagag atggggtttc accatgttgg ccaggctggt    13080

ctcgaactcc taacctcagg cgatctggcc tcctcagtct cccaaagtgc tgggattaca    13140

ggggttagcc accagacccg gcctaaaaaa attttttaaa ttagccaggc ttggccggta    13200

tcatgccatt gcactgcagc ctgggtggca agagggaagg aaactctgtc tcaaaaaaaa    13260

aaaaaaatag tggggtttgg tggctcaccc ctgtggtccc agctcctcag gaggctaagg    13320

caggaggatc acttcagccc agaaagtcaa ggctgcagtg agccgtgttc acgccactgt    13380

cctccagcct ggacaacaga atgagaccct gtctcagaga aaataaaaaa gagagggaaa    13440

tgcatcaggg gcagaggaat cagacattgc caaggctggg aggcagaacc tggctggagc    13500

agaggcgtgt aagagagagt ggtaggcaga gtaggcaagg acgtcagagg gctgatgggg    13560

ccatatcagg tggggccttg agggctggcc atggggactt tgcttctacc ctgagtgaga    13620

tggagctatg gatgtgaact gataggggtg ttcacgggct ccttgggagg agggaaggag    13680

gggctgagag accagggagt aggctgctgg gctggtccag gcaagaggta acagtggaca    13740

ggaccaggcg gagtgagaag aggtcagatt tggaattatt gtgatcagca gacagctctt    13800

acctggggtg tgagggaaag aggagcccca gaggactccc ctgtttttgc aactggaaag    13860

caatggtcag ccatggcagg gttttgtcct ggcatcaaga caagcgagcc cttggctggg    13920

cacaatggct catgcctgta attccagcac tttgggaggt ggaggagggt ggatcacctg    13980

aggtcaggag tttgagacca gcctggccaa catggcaaaa ccctgtctgt actaaaaata    14040

caaaaattag tcaggcctgg tggtgtgcac ctgtaatccc agctactggg gaggctgagg    14100

caggagaatt gcttgaaccc gggaggcaga ggttgcagtg agccgagatt gcgccactgc    14160

actcagcctg ggtgacaaag cgacactctg tctcaaaaaa aaaaaaaaaa agacaagaga    14220

gcccaggctg atcctgccct gtgttccctc cagctttcct gctctgggac cctaccaagg    14280

tgcccccacg actgcaggct gtgactgatg accacatccg gatgcacaag gtgctgcggg    14340

aatcaggcct gaagtacgtg gctgtgatgc cgccacacat aggtaagcag ggcagggacc    14400

tggtggcacc aatgccatct gcctgttccc tcctgccctc tggggagatc tgcaaggcct    14460

tccctgacca ccctaaaatt gcaaaccttc ctatgatatt gtgacatata tatttggcct    14520

ttgtccctgt ttcctggcat acaactccta aaatccttgg aatctccaaa atggtaaatg    14580

tctttttcta tgctaatgag ttcactgaga gctggcagcc cctaggcagc ttcaggtctg    14640

gtcaccagaa agactaaggc tggattacag ggttgggact ttcacctctg gggagtggtg    14700

agggattgaa ggttgagggg attaccactg gctaatggtt taatccatta tgtctatgga    14760

ttctggggct tcagcctcct gagtagctgg gattacaggc ctgcatcacc atgccccgcc    14820

atggcttaca tttctagtat gggagataga gattagatag atagatagat agatagatag    14880

atagatagat agatagatag atacataggc caggcatggt ggttcacacc tgtaatctca    14940

tcactttggg aagccaagac gggaggattt cttcagccca ggagtttgag accagcctgg    15000

gcaacataga cttatctcta caaaaaaaaa aaaaaattag ctgggcgtcg tggcacacac    15060

ctgtggtccc agctactggg aggcgggagg atggcttgag cccaggagat caaggctgca    15120

ataaactgtt gcccaggctg ctgtactcca gcctgggtaa tagagtgaga ccctgtctaa    15180

aaaaaaaaag aaaaagacaa gaaaagatag atattaatgg ccgggtgcgg tggctcacgc    15240

ctgtaatccc agcactttga gaggccgagg cgggcagatc acaaggtcag gagatcgaga    15300

ccatcctggc taacatggtg aaaccccatt ctcctgccca gcctcccgag tagctgggac    15360

tacaggcgcc cgccaccaca cctggctaat tttttgtatt ttttaataca gacggggttt    15420

cacagtgtta gccaggatgg tctcaatctc ctgaccttgt gatccgcccg cctcggcctc    15480

ccaaagtgct gggattacag gcgtgagcca ctgcgcctgg cttttttttt tttttttttt    15540

ttttttttga gacagagtct tgctctgccg ccaggctgga gtacagtggt gcgatcttgg    15600

ctcactgcaa ccttttgcct cctgggttca agtgattctc ctgcctcagc cccccgaata    15660

gctgggacta caggcgcgtg ccaccacgcc cagctaattt ttgtattttt agtagagacg    15720

gggtttcacc atattggcca agatggtctc gatctcttga cctcgtgatc tgcccacctt    15780

ggcctcccaa agtgctggga ttacaggcgt gagccaccac gcccagccaa gtgtgtgaaa    15840

acttccacac ctcccgattt gaaagcatta aaggtttatg aatacacata agccctttgt    15900

ttaggttcaa tgcttagcat tttatcctgt tgtctctccc tctctcctcc tctctctctc    15960

tccatgaata tatagttaga ttttgctgaa tatattgtga aaacatatat gcatatgtat    16020

atttggctta atcatttgag aggaattgca acattgtcgc acttaactcc taaataccta    16080

gacagccatc tcctaaaaga aagatatttg cacacaaaac atgctcacac ctaaggaaag    16140

tgacatttac tctgtcatat catttagtat ccactccgta gtaaaatttc cccaactgtc    16200

aggccagcgt ggtggctcac atctgtaatc ccagcacttt gggaggctga ggcgggtgga    16260

tctcttgagg tcaggagttc aaaaccagcc tggccaacgt ggtgagaccc cgtctctact    16320

aaaaatacaa aaattagcca ggtgtggtgg cggacacctg taatcccaga tactcgggag    16380

gctgaggcac aagaattgct tgaacctggg aggtggaggt tgcagtgagc caagattgca    16440

ccactgtact ccagcctggg tgacagagca agactctatc caaaaaagaa aaaaaaaaat    16500

tcaacccact ctgccctttt tctttaagtt tctcataaca ttaaccaggc caggtgactt    16560

taaaggccca cattctggat ttttctagct gttttgtcac agattcagat taaacatgtt    16620

gggcaggaat gccacatggg tgaaggtgtg tgttcctttt ttttttttga gacagggtct    16680

ccctctgtag cccaggctgg agcgcaatgg cacaatcttg gctcactgca acctccgcct    16740

tctgggctca agtgattctc ctgcccaagt agctgggact acaggcataa gccaccacac    16800

tcagcgaatt tttgcatttt ttgtagagat gtggttttgc catgttggct ggtctcaaac    16860

tcctgagctc aagtgatcct cccaccttgg cctcccgaag tgctgagatt acaggcgtga    16920

gccactgtgc ccagccaggg caggagcttc ctgtctgctt tgtcccaagc aaacacacag    16980

ccaagggtgt gtgttccata ctgtgcataa ttccagcctg tctctgtttg ggtgatggta    17040

cattgtatcc ctaagtttag ttggttactg tcagatagac agatatatat ctatctgaca    17100

aatatatata tatatatata tatatatata tatatatttg ttgttgttgt tgttagagac    17160

aaggtcttgc tctgtcgtcc cggctggagt gcagtgtcac gatcatggct cactgtagct    17220

tcaacttccc tggctcaagc aattctccag cctcagcctc ctgagtagtt gggactacag    17280

gggcatgcca ctgcacccgg ctgatttttg tatttttagt ggactcaggg tctccctgtg    17340

ttgcccagga tagtttcaaa ctcctgggct tgagtgatac tcctgtctca gcctcccaaa    17400

gtgccaggat tacaggcatg agccaccgcc actggccagg gcaggggatt cctgtctgct    17460

ttgtcccttg cttgggtgcc cagcacctgg ccacacaata ggtaatcaat aaggatttat    17520

cgaatgaatg aagcaaagga tatagatgag cacctgcata tggaaagtcc attcttggct    17580

gtgacaccac ccaggctgga cacacagtag gcaccctggg aaggtctttc tgggggtcga    17640

attttggggg aagggaaagg tgtctgcttt atccagcccc tcttgtcttt acttcatagg    17700

agaccagcca ctaactgggg cgtacacagt gaccctggat ggacgagggc cctcaagggt    17760

catctccaaa catgacctgg gccatttcat gctgcgctgc ctcaccaccg atgagtacga    17820

cggacacagc acctacccct cccaccagta ccagtagcac tctgtcccca tctgggaggg    17880

tggcattctg ggacatgagg agcaaaggaa gggggcaata aatgttgagc caagagcttc    17940

aaattactct agagaaaccg actgtgtgac tcttcctc                            17978


