                         SEQUENCE LISTING

<110>  The Trustees of Indiana University
       Weiss, Michael
       Jarosinski, Mark
       Dhayalan, Balamurugan
       Varas, Nicolas
 
<120>  CONFORMATIONALLY CONSTRAINED GLUCAGON ANALOGUES AND THEIR USE IN 
       GLUCAGON-SINGLE CHAIN INSULIN FUSION PROTEINS

<130>  29920-352723

<150>  63/147,611
<151>  2019-02-09

<160>  132   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Arg 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is 2,4-Diaminobutyric acid (Dab)

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is ornithine

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Asp 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is orinithin

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is orinithin

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is orinithin

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Arg Ala Gln Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Lys Trp Leu Met Glu Thr 
            20                  25                  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Arg Ala Gln Glu Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is D-Cys

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Xaa Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position is D-Cys

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Cys Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is D-Cys

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Arg Ala Cys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is D-Cys

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr 
            20                  25                  


<210>  21
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 17 is ornithine

<400>  21

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  22
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 17 is ornithine

<400>  22

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(13)
<223>  lactam ring formed between side chains of Xaa at position 9 and 
       13.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Lys Tyr Ser Xaa Glu Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  25
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  lactam ring formed between side chains of Xaa at position 12 and 
       16.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is onithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is onithine

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  lactam ring formed between side chains of Xaa at position 17 and 
       21.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<400>  26

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Xaa Ala Gln Glu Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chains of Xaa at position 24 and 
       28.

<400>  27

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Lys Trp Leu Met Glu Thr Glu Glu Lys 
            20                  25                  30          


<210>  28
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<400>  28

His Xaa Gln Gly Cys Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Cys Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is orinithine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is orinithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is orinithine

<400>  29

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Xaa 
1               5                   10                  15      


Cys Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30  


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is D-Cys

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Xaa Phe Val Cys Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Cys Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Cys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Cys Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Cys Asp Phe Val Gln Trp Leu Cys Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Cys Thr 
            20                  25                  


<210>  39
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is ornithine

<400>  39

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Glu Gly Ile Leu Glu 
            20                  25                  30          


Gln Cys Cys Glu Ser Ile Cys Ser Leu Glu Gln Leu Glu Asn Tyr Cys 
        35                  40                  45              


Asn 
    


<210>  40
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  40

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Glu Gly Phe Phe Tyr Thr Pro Glu Thr Glu Ala 
            20                  25                  30          


Ala Ala Ala Ala Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 
        35                  40                  45              


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  41
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa at position 54 is ornithine

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
        35                  40                  45              


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Glu Gly Ile Leu Glu 
    50                  55                  60                  


Gln Cys Cys Glu Ser Ile Cys Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
65                  70                  75                  80  


<210>  42
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<400>  42

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
        35                  40                  45              


Leu Val Cys Gly Glu Gly Phe Phe Tyr Thr Pro Glu Thr Glu Ala Ala 
    50                  55                  60                  


Ala Ala Ala Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Leu Glu 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Cys Asn 
                85          


<210>  43
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  43

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu 
            20                  25                  30          


Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly 
        35                  40                  45              


Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg 
    50                  55                  60                  


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
65                  70                  75                  80  


Glu Asn Tyr Cys Asn 
                85  


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  44

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  45

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  47
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog

<400>  47

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<400>  49

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<400>  50

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  51
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<400>  51

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  52
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  52

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  53
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  53

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  54
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  55

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr 
            20                  25                  


<210>  56
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  56

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  57
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  57

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  58
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is D-Cys

<400>  58

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Cys 
            20                  25                  30  


<210>  59
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is D-Cys

<400>  59

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Cys Glu Glu 
            20                  25                  30          


Lys 
    


<210>  60
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  61
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  61

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  62
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is Orn

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chains of Xaa at position 20 and 
       24.

<400>  62

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  63
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is Orn

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chains of Xaa at position 24 and 
       28.

<400>  63

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr Glu Glu Lys 
            20                  25                  30          


<210>  64
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 18 is D-Cys

<400>  64

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  65
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is D-Cys

<400>  65

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Xaa Phe Val Cys Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  66
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 24 and 
       28.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  67
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<400>  67

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Pro Asn Thr Gly Gly Gly 
            20                  25                  30          


<210>  68
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Pro Asn Thr Gly Gly Gly 
            20                  25                  30          


<210>  69
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  69

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Pro Asn Thr Gly Gly Gly 
            20                  25                  30          


<210>  70
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is D-Cys

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Xaa Phe Val Cys Trp Leu Pro Asn Thr Gly Gly Gly 
            20                  25                  30          


<210>  71
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is Orn.

<400>  71

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
            20                  25                  30          


Gly Pro Xaa Xaa Gly Ile Val Glu Gln Cys Cys Gln Ser Ile Cys Ser 
        35                  40                  45              


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  72
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin peptide analog


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is Orn.

<400>  72

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
            20                  25                  30          


Gly Pro Xaa Xaa Gly Ile Leu Glu Gln Cys Cys Gln Ser Ile Cys Ser 
        35                  40                  45              


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  73
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon/insulin fusion peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa at position 54 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa at position 67 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is ornithine

<400>  73

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
        35                  40                  45              


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
    50                  55                  60                  


Gly Pro Xaa Xaa Gly Ile Val Glu Gln Cys Cys Gln Ser Ile Cys Ser 
65                  70                  75                  80  


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
                85                  


<210>  74
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon/insulin fusion peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa at position 54 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa at position 67 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is ornithine

<400>  74

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
        35                  40                  45              


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
    50                  55                  60                  


Gly Pro Xaa Xaa Gly Ile Leu Glu Gln Cys Cys Gln Ser Ile Cys Ser 
65                  70                  75                  80  


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
                85                  


<210>  75
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon/insulin fusion peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa at position 54 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa at position 67 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is ornithine

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Lys Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
        35                  40                  45              


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
    50                  55                  60                  


Gly Pro Xaa Xaa Gly Ile Val Glu Gln Cys Cys Gln Ser Ile Cys Ser 
65                  70                  75                  80  


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
                85                  


<210>  76
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon/insulin fusion peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa at position 54 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa at position 67 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is ornithine

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Lys Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
        35                  40                  45              


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
    50                  55                  60                  


Gly Pro Xaa Xaa Gly Ile Leu Glu Gln Cys Cys Gln Ser Ile Cys Ser 
65                  70                  75                  80  


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
                85                  


<210>  77
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  77

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  78
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  79
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid

<400>  79

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  80
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Orn, Diamino-Butyric Acid or
       Diamino-Proprionic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  83
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg.

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  85
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  86
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg.

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Xaa Asp Phe Cys Gln Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<400>  87

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr 
            20                  25                  


<210>  88
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  88

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  89
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg.

<400>  89

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Xaa Trp Leu Cys Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  90
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is D-Cys

<400>  90

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Cys 
            20                  25                  30  


<210>  91
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is D-Cys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  91

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Cys Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is D-Cys.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys or Arg.

<400>  92

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Cys Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  93
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is D-Cys.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<400>  93

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr Xaa Cys 
            20                  25                  30      


<210>  94
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is D-Cys.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  94

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr Xaa Cys Xaa 
            20                  25                  30          


Xaa 
    


<210>  95
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is D-Cys.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys or Arg.

<400>  95

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr Xaa Cys Xaa 
            20                  25                  30          


Xaa 
    


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chains of Xaa at position 20 and 
       24.

<400>  96

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chains of Xaa at position 20 and 
       24.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  97

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  98
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chains of Xaa at position 20 and 
       24.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  98

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  99
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chains of Xaa at position 20 and 
       24.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  99

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chains of Xaa at position 24 and 
       28.

<400>  100

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Lys Trp Leu Met Glu Thr 
            20                  25                  


<210>  101
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chains of Xaa at position 24 and 
       28.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  101

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Lys Trp Leu Met Glu Thr Xaa 
            20                  25                  30  


<210>  102
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chains of Xaa at position 24 and 
       28.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  102

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Lys Trp Leu Met Asn Glu Xaa Xaa Xaa 
            20                  25                  30          


<210>  103
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chains of Xaa at position 20 and 
       24.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg.

<400>  103

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Lys Trp Leu Met Glu Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  104
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (27)..(31)
<223>  lactam ring formed between side chains of Xaa at position 27 and 
       31.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<400>  104

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Lys Asn Thr Xaa Glu 
            20                  25                  30      


<210>  105
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (27)..(31)
<223>  lactam ring formed between side chains of Xaa at position 27 and 
       31.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  105

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Xaa Glu Xaa 
            20                  25                  30          


Xaa 
    


<210>  106
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (27)..(31)
<223>  lactam ring formed between side chains of Xaa at position 27 and 
       31.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  106

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Xaa Glu Xaa 
            20                  25                  30          


Xaa 
    


<210>  107
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(27)
<223>  bifunctional bromacetyl linker connects the side chains of C20 
       and C27

<400>  107

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Cys Asp Phe Val Gln Trp Leu Cys Asn Thr 
            20                  25                  


<210>  108
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(27)
<223>  bifunctional bromacetyl linker connects the side chains of C20 
       and C27

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid

<400>  108

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Cys Asp Phe Val Gln Trp Leu Cys Asn Thr Xaa 
            20                  25                  30  


<210>  109
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(27)
<223>  bifunctional bromacetyl linker connects the side chains of C20 
       and C27

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  109

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Cys Asp Phe Val Gln Trp Leu Cys Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  110
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (20)..(27)
<223>  bifunctional bromacetyl linker connects the side chains of C20 
       and C27

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg.

<400>  110

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Cys Asp Phe Val Gln Trp Leu Cys Asn Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (21)..(28)
<223>  bifunctional bromacetyl linker connects the side chains of C21 
       and C28

<400>  111

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Cys Phe Val Gln Trp Leu Met Cys Thr 
            20                  25                  


<210>  112
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (21)..(28)
<223>  bifunctional bromacetyl linker connects the side chains of C21 
       and C28

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid

<400>  112

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Cys Phe Val Gln Trp Leu Met Cys Thr Xaa 
            20                  25                  30  


<210>  113
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (21)..(28)
<223>  bifunctional bromacetyl linker connects the side chains of C21 
       and C28

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  113

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Cys Phe Val Gln Trp Leu Met Cys Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  114
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (21)..(28)
<223>  bifunctional bromacetyl linker connects the side chains of C21 
       and C28

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Lys or Arg.

<400>  114

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Cys Phe Val Gln Trp Leu Met Cys Thr Xaa Xaa Xaa 
            20                  25                  30          


<210>  115
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(31)
<223>  bifunctional bromacetyl linker connects the side chains of C24 
       and C31

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<400>  115

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Xaa Cys 
            20                  25                  30      


<210>  116
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (24)..(31)
<223>  bifunctional bromacetyl linker connects the side chains of C24 
       and 31.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  116

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Xaa Cys Xaa 
            20                  25                  30          


Xaa 
    


<210>  117
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Orn.

<220>
<221>  MISC_FEATURE
<222>  (24)..(31)
<223>  bifunctional bromacetyl linker connects the side chains of C24 
       and C31.

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at position 30 is Ala, Gly, Glu, Arg, Lys, Orn, 
       Diamino-Butyric Acid or Diamino-Proprionic Acid.

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Gly, Ala, Ser, Gln or Glu.

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Arg, Lys, Orn, Diamino-Butyric Acid or 
       Diamino-Proprionic Acid.

<400>  117

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Lys Leu Asp Ser 
1               5                   10                  15      


Glu Xaa Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Xaa Cys Xaa 
            20                  25                  30          


Xaa 
    


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Tyr or Orn

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  intrachain bridge formed between side chains of Xaa at position 
       13 and 17.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Arg or Orn

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Met or Pro

<400>  118

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Asp Ser 
1               5                   10                  15      


Xaa Xaa Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  119
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin B chain peptide analog

<400>  119

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  120
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin B chain peptide analog

<400>  120

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  121
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin B chain peptide analog

<400>  121

Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Glu Lys Thr 
            20                  25                  30  


<210>  122
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insulin B chain peptide analog

<400>  122

Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  123
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<400>  123

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu Glu Lys 
            20                  25                  30          


<210>  124
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment

<400>  124

Leu Met Asn Thr 
1               


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Ala or Pro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  125

Leu Xaa Xaa Thr Gly 
1               5   


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  126

Leu Ala Xaa Thr Gly 
1               5   


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  127

Leu Pro Xaa Thr Gly 
1               5   


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  128

Leu Pro Xaa Ala Gly 
1               5   


<210>  129
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  129

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Thr Gly Gly Gly 
            20                  25                  30          


<210>  130
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  130

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Thr Gly 
            20                  25                  30  


<210>  131
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  131

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Thr Gly 
            20                  25                  30  


<210>  132
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon peptide analog


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  lactam ring formed between side chains of Xaa at position 13 and 
       17.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is D-Cys

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  132

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Lys Leu Asp Ser 
1               5                   10                  15      


Glu Arg Ala Xaa Asp Phe Cys Gln Trp Leu Xaa Xaa Thr Gly 
            20                  25                  30  


