                               SEQUENCE LISTING                               

<110> UNIVERSITY OF HOUSTON SYSTEM

<120> ONCOLYTIC VIRUS FOR SYSTEMIC DELIVERY AND ENHANCED ANTI-TUMOR ACTIVITIES 

<130> 312170.03601

<140> PCT/US2022/015703
<141> 2022-02-08

<160> 21                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic
      amplification primer for left-flanking region of
      Herpes simplex virus-2 (HSV-2) ribonucleotide
      reductase large subunit (ICP10, RR1)

<400> 1
ttggtcttca cctaccgaca                                             20    


<210> 2
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic
      amplification primer for left-flanking region of
      Herpes simplex virus-2 (HSV-2) ribonucleotide
      reductase large subunit (ICP10, RR1)

<400> 2
caaaggcaag tagcgcag                                               18    


<210> 3
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic PCR
      amplification primer for constitutive immediate
      early cytomegalovirus (CMV) promoter and enhanced
      green fluorescent protein (EGFP)

<400> 3
atggtgagca agggcgag                                               18    


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic PCR
      amplification primer for constitutive immediate
      early cytomegalovirus (CMV) promoter and enhanced
      green fluorescent protein (EGFP)

<400> 4
cgtacctgct cgacatgttc                                             20    


<210> 5
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:C-type
      retrovirus gibbon ape leukemia virus (GALV)
      fusogenic membrane envelope glycoprotein (FMG)
      domain

<400> 5
ttaagcctgg taccgtaaca atccctcacc cgttccaggt cggggatcaa gtgcttgtca 60    
gacgccatcg acccagcagc cttgagcctc ggtggaaagg cccatacctg gtgttgctga 120   


<210> 6
<211> 2890
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:C-type
      retrovirus murine leukemia virus (MLV) fusogenic
      membrane envelope glycoprotein (FMG) domain

<400> 6
acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta ccgtcagcgg 60    
gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc 120   
caccaccggg agctcactta caggcccttc aagcagtaca acgagaggtc tggaagccac 180   
tggctgcggc ctatcaggac cagcaagacc agccagtgat accacacccc ttccgtgtcg 240   
gcgacaccgt gtgggtacgc cggcaccaga ctaagaactt ggaacctcgt tggaaaggac 300   
cctataccgt cctgctgacc acccccaccg ctctcaaagt agacggcatc gctgcgtgga 360   
tccacgccgc tcacgtaaag gcggcgacaa cccctccggc cggaacagca tcaggaccga 420   
catggaaggt ccagcgttct caaaacccct taaagataag attaacccgt ggggccccct 480   
gatagtcctg gggatcttaa taagggcagg agtatcagta caacatgaca gccctcacca 540   
ggtcttcaat gttacttgga gagttaccaa cttaatgaca ggacaaacag ctaacgctac 600   
ctccctcctg gggacaatga cagatgcctt tcctatgctg tacttcgact tgtgcgattt 660   
aataggggac gattgggatg agactggact tgggtgtcgc actcccgggg gaagaaaacg 720   
ggcaagaaca tttgacttct atgtttgccc cgggcatact gtaccaacag ggtgtggagg 780   
gccgagagag ggctactgtg gcaaatgggg ctgtgagacc actggacagg catactggaa 840   
gccatcatca tcatgggacc taatttccct taagcgagga aacacccctc ggaatcaggg 900   
cccctgttat gattcctcag tggtctccag tggcatccag ggtgccacac cggggggtcg 960   
atgcaatccc ctagtcctag aattcactga cgcgggtaaa aaggccagct gggatggccc 1020  
caaagtatgg ggactaagac tgtaccaatc cacagggatc gacccggtga cccggttctc 1080  
tttgacccgc caggtcctca atatagggcc ccgcatcccc attgggccta atcccgtgat 1140  
cactggccaa ctacccccct cccgacccgt gcagatcagg ctccccaggc ctcctcagac 1200  
tcctcctaca ggcgcagcct ctatggtccc tgggactgcc ccaccgtctc aacaacctgg 1260  
gacgggagac aggctgctaa acctggtaga tggagcatac caagcactca acctcaccag 1320  
tcctgacaaa acccaagagt gctggttgtg tctggtatcg ggacccccct actacgaagg 1380  
ggttgccgtc ctaggtactt actccaacca tacctctgcc ccagctaact gctccgcggc 1440  
ctcccaacac aagctgaccc tgtccgaagt aaccggacag ggactctgcg taggagcagt 1500  
tcccaaaacc catcaggccc tgtgtaatac cacccaaaag acgagcgacg ggtcctacta 1560  
tctggctgct cccgccggga ccatttgggc ttgcaacacc gggctcactc cctgcctatc 1620  
tactactgta ctcaatctaa ccacagatta ttgtgtatta gttgaactct ggcccagagt 1680  
aatttaccac tcccccgatt atatgtatgg tcagcttgaa cagcgtacca aatataaaag 1740  
agagccagta tcattgaccc tggcccttct actaggagga ttaaccatgg gagggattgc 1800  
agctggaata gggacgggga ccactgcctt aattaaaacc cagcagtttg agcagcttca 1860  
tgccgctatc cagacagacc tcaacgaagt cgaaaagtca attaccaacc tagaaaagtc 1920  
actgacctcg ttgtctgaag tagtcctaca gaaccgcaga ggcctagatt tgctattcct 1980  
aaaggaggga ggtctctgcg cagccctaaa agaagaatgt tgtttttatg cagaccacac 2040  
ggggctagtg agagacagca tggccaaatt aagagaaagg cttaatcaga gacaaaaact 2100  
atttgagaca ggccaaggat ggttcgaagg gctgtttaat agatccccct ggtttaccac 2160  
cttaatctcc accatcatgg gacctctaat agtactctta ctgatcttac tctttggacc 2220  
ttgcattctc aatcgattag tccaatttgt taaagacagg atatcagtgg tccaggctct 2280  
agttttgact caacaatatc accagctgaa gcctatagag tacgagccat agataaaata 2340  
aaagatttta tttagtctcc agaaaaaggg gggaatgaaa gaccccacct gtaggtttgg 2400  
caagctagct taacgccatt ttgcaaggca tggaaaaata cataactgag aatagagaag 2460  
ttcagatcaa ggtcaggaac agatggaaca gctgaatatg ggccaaacag gatatctgtg 2520  
gtaagcagtt cctgccccgg ctcagggcca agaacagatg gaacagctga atatgggcca 2580  
aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc 2640  
cagatgcggt ccagccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc 2700  
aaggacctga aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc 2760  
tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggggc 2820  
gccagtcctc cgattgactg agtcgcccgg gtacccgtgt atccaataaa ccctcttgca 2880  
gttgcatccg                                                        2890  


<210> 7
<211> 2384
<212> DNA
<213> Measles virus

<220> 
<223> Measles virus fusion protein

<400> 7
tcgagggcca aggaacatac acacccaaca gaacccagac cccggcccac ggcgccgcgc 60    
ccccaacccc cgacaaccag agggagcccc caaccaatcc gccggctccc ccggtgccca 120   
caggcaggga caccaacccc cgaacagacc cagcacccaa ccatcgacaa tccaagacgg 180   
gggggccccc ccaaaaaaaa ggcccccagg ggccgacagc cagcaccgcg aggaagccca 240   
cccaccccac acacgaccac ggcaaccaaa ccagaaccca gaccaccctg ggtcaccagc 300   
tccagacctc ggtcatcacc ccgcagaaag gaaaggcaca acccgcgacc ccagccccga 360   
tccggcgggg agccacccaa cccgaaccag cacccaagag cgatccccga aggacccccg 420   
aaccgcaaag gacatcagta tcccacagcc tctccaagtc ccccggtctc ctcctcttct 480   
cgaagggacc aaaagatcaa tccaccacca cacacccgac gacactcaac tccccacccc 540   
taaaggagac accgggaatc ccagaatcaa gactcatcca atgtccatca tgggtctcaa 600   
ggtgaacgtc tctgccatat tcatggcagt actgttaact ctccaaacac ccaccggtca 660   
aatccattgg ggcaatctct ctaagatagg ggtggtagga ataggaagtg caagctacaa 720   
agttatgact cgttccagcc atcaatcatt agtcataaaa ttaatgccca atataactct 780   
cctcaataac tgcacgaggg tagagattgc agaatacagg agactactga gaacagtttt 840   
ggaaccaatt agagatgcac ttaatgcaat gacccagaat ataagaccgg ttcagagtgt 900   
agcttcaagt aggagacaca agagatttgc gggagtagtc ctggcaggtg cggccctagg 960   
cgttgccaca gctgctcaga taacagccgg cattgcactt caccagtcca tgctgaactc 1020  
tcaagccatc gacaatctga gagcgagcct ggaaactact aatcaggcaa ttgaggcaat 1080  
cagacaagca gggcaggaga tgatattggc tgttcagggt gtccaagact acatcaataa 1140  
tgagctgata ccgtctatga accaactatc ttgtgattta atcggccaga agctcgggct 1200  
caaattgctc agatactata cagaaatcct gtcattattt ggccccagct tacgggaccc 1260  
catatctgcg gagatatcta tccaggcttt gagctatgcg cttggaggag acatcaataa 1320  
ggtgttagaa aagctcggat acagtggagg tgatttactg ggcatcttag agagcagagg 1380  
aataaaggcc cggataactc acgtcgacac agagtcctac ttcattgtcc tcagtatagc 1440  
ctatccgacg ctgtccgaga ttaagggggt gattgtccac cggctagagg gggtctcgta 1500  
caacataggc tctcaagagt ggtataccac tgtgcccaag tatgttgcaa cccaagggta 1560  
ccttatctcg aattttgatg agtcatcgtg tactttcatg ccagagggga ctgtgtgcag 1620  
ccaaaatgcc ttgtacccga tgagtcctct gctccaagaa tgcctccggg ggtccaccaa 1680  
gtcctgtgct cgtacactcg tatccgggtc ttttgggaac cggttcattt tatcacaagg 1740  
gaacctaata gccaattgtg catcaatcct ttgcaagtgt tacacaacag gaacgatcat 1800  
taatcaagac cctgacaaga tcctaacata cattgctgcc gatcactgcc cggtagtcga 1860  
ggtgaacggc gtgaccatcc aagtcgggag caggaggtat ccagacgctg tgtacttgca 1920  
cagaattgac ctcggtcctc ccatatcatt ggagaggttg gacgtaggga caaatctggg 1980  
gaatgcaatt gctaagttgg aggatgccaa ggaattgttg gagtcatcgg accagatatt 2040  
gaggagtatg aaaggtttat cgagcactag catagtctac atcctgattg cagtgtgtct 2100  
tggagggttg atagggatcc ccgctttaat atgttgctgc agggggcgtt gtaacaaaaa 2160  
gggagaacaa gttggtatgt caagaccagg cctaaagcct gatcttacgg gaacatcaaa 2220  
atcctatgta aggtcgctct gatcctctac aactcttgaa acacaaatgt tcccacaagt 2280  
ctcctcttcg tcatcaagca accaccgcac ccagcatcaa gcccacctga accagctaaa 2340  
ttatctccgg cttccctctg gccgaacaat atcggtagtt aatt                  2384  


<210> 8
<211> 2535
<212> DNA
<213> Human immunodeficiency virus

<220> 
<223> HIV gp160

<400> 8
atgagagtga tggggataca gaggaattgg ccacaatggt ggatatgggg caccttaggc 60    
ttttggatga taataatttg tagggtggtg gggaacttga acttgtgggt cacagtctat 120   
tatggggtac ctgtgtggaa agaagcaaaa actactctat tctgtgcatc agatgctaaa 180   
gcatatgata aagaagtaca taatgtctgg gctacacatg cctgtgtacc cacagacccc 240   
aacccacgag aaatagtttt ggaaaatgta acagaaaatt ttaacatgtg gaaaaatgac 300   
atggtggatc agatgcatga ggatataatc agtttatggg atcaaagcct aaaaccatgt 360   
gtaaagttga ccccactctg tgtcacttta aattgtacaa atgcacctgc ctacaataat 420   
agcatgcatg gagaaatgaa aaattgctct ttcaatacaa ccacagagat aagagatagg 480   
aaacagaaag cgtatgcact tttttataaa cctgatgtag tgccacttaa taggagagaa 540   
gagaataatg ggacaggaga gtatatatta ataaattgca attcctcaac cataacacaa 600   
gcctgtccaa aggtcacttt tgacccaatt cctatacatt attgtgctcc agctggttat 660   
gcgattctaa agtgtaataa taagacattc aatgggacag gaccatgcaa taatgtcagc 720   
acagtacaat gtacacatgg aattatgcca gtggtatcaa ctcaattact gttaaatggt 780   
agcctagcag aagaagagat aataattaga tctgaaaatc tgacaaacaa tatcaaaaca 840   
ataatagtcc accttaataa atctgtagaa attgtgtgta caagacccaa caataataca 900   
agaaaaagta taaggatagg accaggacaa acattctatg caacaggtga aataatagga 960   
aacataagag aagcacattg taacattagt aaaagtaact ggaccagtac tttagaacag 1020  
gtaaagaaaa aattaaaaga acactacaat aagacaatag aatttaaccc accctcagga 1080  
ggggatctag aagttacaac acatagcttt aattgtagag gagaattttt ctattgcaat 1140  
acaacaaaac tgttttcaaa caacagtgat tcaaacaacg aaaccatcac actcccatgc 1200  
aagataaaac aaattataaa catgtggcag aaggtaggac gagcaatgta tgcccctccc 1260  
attgaaggaa acataacatg taaatcaaat atcacaggac tactattgac acgtgatgga 1320  
ggaaagaata caacaaatga gatattcaga ccgggaggag gaaatatgaa ggacaattgg 1380  
agaagtgaat tatataaata taaagtggta gaaattgagc cattgggagt agcacccact 1440  
aaatcaaaaa ggagagtggt ggagagagaa aaaagagcag tgggactagg agctgtactc 1500  
cttgggttct tgggagcagc aggaagcact atgggcgcgg cgtcaataac gctgacggta 1560  
caggccagac aactgttgtc tggtatagtg caacagcaaa gcaatttgct gagagctata 1620  
gaggcgcaac agcatatgtt gcaactcacg gtctggggca ttaagcagct ccagacaaga 1680  
gtcttggcta tagagagata cctaaaggat caacagctcc tagggctttg gggctgctct 1740  
ggaaaaatca tctgcaccac tgctgtgcct tggaactcca gttggagtaa taaatctcaa 1800  
gaagatattt gggataacat gacctggatg cagtgggata gagaaattag taattacaca 1860  
ggcacaatat ataggttact tgaagactcg caaaaccagc aggagaaaaa tgaaaaagat 1920  
ttattagcat tggacagttg gaaaaacttg tggaattggt ttaacataac aaattggctg 1980  
tggtatataa aaatattcat catgatagta ggaggcttga taggtttgag aataattttt 2040  
ggtgtactcg ctatagtgaa aagagttagg cagggatact cacctttgtc gtttcagacc 2100  
cttaccccaa gcccgagggg tcccgacagg ctcggaagaa tcgaagaaga aggtggagag 2160  
caagacaaag acagatccat tcgattagtg agcggattct tagcacttgc ctgggacgat 2220  
ctgcggagcc tgtgcctctt cagctaccac cacttgagag acttcatatt gattgcagcg 2280  
agagcagcgg aacttctggg acgcagcagt ctcaggggac tgcagagagg gtgggaagcc 2340  
cttaagtatc tgggaaatct tgtgcagtat gggggtctgg agctaaaaag aagtgctatt 2400  
aaactgtttg ataccatagc aatagcagta gctgaaggaa cagataggat tcttgaagta 2460  
atacagagaa tttgtagagc tatccgccac atacctataa gaataagaca gggctttgaa 2520  
gcagctttgc aataa                                                  2535  


<210> 9
<211> 2577
<212> DNA
<213> Simian immunodeficiency virus

<220> 
<223> SIV gp160

<220> 
<221> modified_base
<222> (1)..(2577)
<223> n = g, a, c or t

<400> 9
atgaggaagc cgatacatat tatttggggt ctggctttgc taatccagtt tatagagaag 60    
gggacgaatg aagactatgt aacagtattc tatggagtcc ctgtctggag aaatgcgaca 120   
cctactctat tttgtgccac aaatgcctcc atgacaagta cagaggtgca caatgtatgg 180   
gcaactacca gttgtgtgcc aatagatcca gatcctattg tagttaggct caatacctca 240   
gtctggttta atgcttataa aaattatatg gtagaaagta tgacagaaga tatgntacaa 300   
ttattccaac aaagccataa gccatgtgta aaactaacac ctatgtgtat aaaaatgaat 360   
tgtacaggat acaatggaac acctacaaca ccaagtacaa caacaagtac agtaacacca 420   
aagacaacaa caccaatagt agatggcatg aagctacaag aatgtaactt taatcagagc 480   
acaggattta aagataagaa acaaaaaatg aaagccatat tttataaagg agatcttatg 540   
aagtgtcagg acaacaatga gactaactgc tattacttat ggcactgcaa caccacaact 600   
atcacacaat cctgtgaaaa gtctactttt gaaccaattc ctatacatta ttgtgctcca 660   
gcaggatatg ctatattgag atgtgaagat gaggatttta caggagtagg gatgtgtaaa 720   
aatgtctcag tagtacattg cactcatgga ataagcccaa tggtggcaac atggttacta 780   
ttaaatggaa cttaccaaac aaacacttca gtagtaatga atggtcgcaa aaatgaatct 840   
gtgcttgtaa gatttggaaa agaattcgaa aacttaacaa ttacatgtat aagaccagga 900   
aataggacag taagaaatct acaaatagga ccaggaatga ctttctataa cgtagaaata 960   
gcaacaggag acactaggaa agcgttctgt acagtcaata agacgctatg ggaacaagca 1020  
cgtaacaaaa cagagcacgt tcttgcggag cattggaaaa aagtagacaa caaaaccaat 1080  
gcgaaaacaa tatggacatt ccaagatgga gatcctgaag taaaagtgca ttggtttaat 1140  
tgccaaggag aattctttta ttgtgatata acaccttggt tcaatgccac atacacggga 1200  
aacctcatca caaacggagc cctcatagca cattgcagaa ttaagcagat agttaatcat 1260  
tggggcatag tttcaaaagg catttactta gcccctagga gagggaatgt ttcctgtact 1320  
tccagcataa ctggaattat gttggaaggt caaatatata atgaaactgt taaagtgtca 1380  
cctgctgcaa gagtagcaga ccaatggaga gcggagttgt ccaggtacca ggtggtagag 1440  
attgntccct tgtcagtagc cccaacaaca ggnaaaaggc cagaaataaa acaacactcc 1500  
agacaaaaaa gaggcattgg aatagggctg ttcttcttgg gtcttctcag tgcagctggc 1560  
agtacaatgg gcgcagcgtc aatagcgctg acggcacaga ccaggaattt gntccatggt 1620  
attgtacaac agcaggccaa tctgctgcaa gccatagaga cacagcaaca tctgctacag 1680  
ctctcggtct ggggagtaaa acaactccag gcaagaatgc ttgcagtcga gaagtaccta 1740  
agagatcaac aactattgag cctctggggt tgtgctgaca aggtgacctg tcacactacg 1800  
gtgccttgga ataattcctg ggtaaacttc acgcaaacat gtgcaaagaa cagcagtgat 1860  
atacaatgta tttgggaaaa tatgacatgg caagaatggg acagattagt acagaattca 1920  
acaggacaga tatataatat cttacaaata gcacatgagc aacaagagag aaataaaaag 1980  
gaattatatg aactagacaa atggagctca ttatggaatt ggtttgacat aacacaatgg 2040  
ctatggtata taaaaatatt tattatgata gtaggagcta ttgtaggact aagaattttg 2100  
cttgtattag ttagttgctt aagaaaggtt aggcagggat atcatcctct gtcatttcag 2160  
atccctaccc aaaaccagca ggatccagag cagccagaag aaataagaga agaaggtgga 2220  
agaaaagaca ggatcaggtg gagggccttg cagcacgggt tcttcgcact cttgtgggtg 2280  
gacctgacga gcataatcca gtggatctac cagatctgca gaacctgtct cttgaacctt 2340  
tgggcagtcc tccaacacct ctgcagaatt actttcagac tgtgcaacca tctggagaac 2400  
aatctcagca ccctctggac aataatcaga actgagatca ttaagaacat tgacagactt 2460  
gctattttgg taggggaaaa aacagatagc attcctctag ctctccaaac tattgtcaga 2520  
atcataaggg angtccctag gcgcatcaga cargggttgg aaattgcatt waattaa    2577  


<210> 10
<211> 262
<212> DNA
<213> Human immunodeficiency virus

<220> 
<223> HIV retroviral env protein

<400> 10
ggatcaaagt ctaaagccat gtgtaaaatt aaccccactc tgtgttactt taagttgcga 60    
taatgtgaat attactactg ccaatactac caataccact agtaggcatg ggaaactgat 120   
ggagccagga gaaataaaaa actgctcttt caatatcacc acagacttga gagataagat 180   
gaagaaagaa tatgcacttt tttataacct tgatgtagta caaataaatg atgataatac 240   
tacctatagg ttgataagtt gt                                          262   


<210> 11
<211> 2360
<212> DNA
<213> Ebola virus

<220> 
<223> Reston Ebola virus glycoprotein (Gp)

<400> 11
atacgatgaa gattaaggcg acaacgagcc gaaacttcat ctcttttaaa gatctaacat 60    
tatctgttcc aaagtcatac aaggacacat tcaaatcagg gattgtaagc tgctatttct 120   
tacctcccca aattacctat acaacatggg gtcaggatat caacttctcc aattgcctcg 180   
ggaacgtttt cgtaaaactt cgttcttagt atgggtaatc atcctcttcc agcgagcaat 240   
ctccatgccg cttggtatag tgacaaatag cactctcaaa gcaacagaaa ttgatcaatt 300   
ggtttgtcgg gacaaactgt catcaaccag tcagctcaag tctgtggggc tgaatctgga 360   
aggaaatgga attgcaaccg atgtcccatc agcaacaaaa cgctggggat ttcgttcagg 420   
tgtgcctccc aaggtggtca gctatgaagc cggagaatgg gcagaaaatt gctacaatct 480   
ggagatcaaa aagtcagacg gaagtgaatg cctccctctc cctcccgacg gtgtacgagg 540   
attccctaga tgtcgctatg tccacaaagt tcaaggaaca ggtccttgtc ccggtgactt 600   
agctttccat aaaaatgggg cttttttctt gtatgataga ttggcctcaa ctgtcatcta 660   
ccgagggaca acttttgctg aaggtgtcgt agctttttta attctgtcag agcccaagaa 720   
gcatttttgg aaggctacac cagctcatga accggtgaac acaacagatg attccacaag 780   
ctactacatg accctgacac tcagctacga gatgtcaaat tttgggggca atgaaagtaa 840   
cacccttttt aaggtagaca accacacata tgtgcaacta gatcgtccac acactccgca 900   
gttccttgtt cagctcaatg aaacacttcg aagaaataat cgccttagca acagtacagg 960   
gagattgact tggacattgg atcctaaaat tgaaccagat gttggtgagt gggccttctg 1020  
ggaaactaaa aaaacttttc ccaacaactt catggagaaa acttgcattt ccaaattcta 1080  
tcaacccaca ccaacaactc ctcagatcag agcccggcgg gaactgtcca aggaaaaatt 1140  
agctaccacc cacccgccaa caactccgag ctggttccaa cggattcccc tccagtggtt 1200  
tcagtgctca ctgcaggacg gacagaggaa atgtcgaccc aaggtctaac caacggagag 1260  
acaatcacag gtttcaccgc gaacccaatg acaaccacca ttgccccaag tccaaccatg 1320  
acaagcgagg ttgataacaa tgtaccaagt gaacaaccga acaacacagc atccattgaa 1380  
gactcccccc catcggcaag caacgagaca atttaccact ccgagatgga tccgatccaa 1440  
ggctcgaaca actccgccca gagcccacag accaagacca cgccagcacc cacaacatcc 1500  
ccgatgaccc aggacccgca agagacggcc aacagcagca aaccaggaac cagcccagga 1560  
agcgcagccg gaccaagtca gcccggactc actataaata cagtaagtaa ggtagctgat 1620  
tcactgagtc ccaccaggaa acaaaagcga tcggttcgac aaaacaccgc taataaatgt 1680  
aacccagatc tttactattg gacagctgtt gatgaggggg cagcagtagg attggcatgg 1740  
attccatatt tcggacctgc agcagaaggc atctacattg agggtgtaat gcataatcag 1800  
aatgggctta tttgcgggct acgtcagcta gccaatgaaa ctacccaggc tcttcaatta 1860  
tttctgcggg ccacaacaga actgaggact tactcacttc ttaacagaaa agctattgat 1920  
tttcttcttc aacgatgggg aggtacctgt cgaatcctag gaccatcttg ttgcattgag 1980  
ccacatgatt ggacaaaaaa tattactgat gaaattaacc aaattaaaca tgactttatt 2040  
gacaatcccc taccagacca cggagatgat cttaatctat ggacaggttg gagacaatgg 2100  
atcccggctg gaattgggat tattggagtt ataattgcta taatagccct actttgtata 2160  
tgtaagattt tgtgttgatt tattctgaga tctgagagag aaaaatctca gggttactct 2220  
aaggagaaat attattttta aaatttactt gaatgctgac cacttatctt aaatgagcaa 2280  
ttaataatat gtttttctgc ttctttgctt gatttacaat atgatatttc tcttaataat 2340  
gattaatata ttaagaaaaa                                             2360  


<210> 12
<211> 1733
<212> DNA
<213> Influenza A virus

<220> 
<223> Influenza A virus (A/duck/Alberta/35/76(H1N1))
      haemagglutinin (HA1 and HA2 chains)

<400> 12
agcaaaagca ggggataatc aaatcaatcg agatggaagc aaaactattt gtactattct 60    
gtacattcac tgtactgaaa gctgacacca tctgtgtggg ctaccatgca aacaactcta 120   
cagacactgt tgacacagta ctggaaaaga atgtgaccgt gactcactca gtgaatttgc 180   
tcgaagacag ccataatggg aaactctgca gcctgaacgg gatagctccc ctacaactgg 240   
gaaagtgcaa tgtggcggga tggctcctgg gcaatccaga gtgtgatctt ctactcactg 300   
caaactcatg gtcctacata atagaaactt caaactcaga aaacggaaca tgctaccccg 360   
gtgaattcat agattatgaa gaattaagag agcagctaag ttcaatttct tcatttgaaa 420   
aatttgaaat tttcccgaag gcaagctcat ggccaaatca tgagacaact aaaggtgtta 480   
cagctgcatg ctcttactct ggagccagca gtttttaccg gaatttgctg tggataacaa 540   
agaaagggac ttcatatcca aaactcagca aatcatacac gaacaataag gggaaagaag 600   
tgcttgtgct ctggggggtg caccaccctc caagtgtcag tgagcaacaa agtctatacc 660   
agaatgctga tgcatacgtt tcagttggat cgtcaaaata caaccgaaga ttcgctccgg 720   
aaatagcagc tagacctgaa gttagaggac aggcaggcag aatgaactat tattggacac 780   
tattagacca aggagacact ataacatttg aagccactgg gaatttgata gcaccatggt 840   
atgctttcgc attgaataag gggtctgact ctggaattat aacatcagat gctccagttc 900   
acaattgtga cacaaggtgc caaacccctc atggggcttt gaacagcagc cttccttttc 960   
agaatgtaca tcctatcact attggagaat gtcccaaata cgtcaagagc accaaactaa 1020  
gaatggcaac aggactaaga aatgtcccat ccattcagtc cagaggacta tttggagcaa 1080  
ttgctggatt cattgaggga ggatggacag gcatgataga tggatggtac gggtatcatc 1140  
atcagaatga gcaaggatca ggatatgctg ctgatcagaa aagcacacag aatgcgatcg 1200  
acgggatcac aagtaaggtg aattcggtaa ttgaaaagat gaacactcaa ttcactgcag 1260  
tgggcaaaga attcaataat ttagaaagga gaattgaaaa tttgaataaa aaggtcgatg 1320  
atggattcct ggatgtttgg acatacaatg ccgaactgct cgtcctactt gaaaatgaaa 1380  
gaactctaga ctttcatgac tccaatgtga gaaatttata tgagaaggtc aaatcgcaat 1440  
tgaggaataa tgccaaagaa attgggaatg gttgttttga gttctaccac aagtgtgatg 1500  
atgagtgcat ggaaagtgtg aagaacggca catacgacta ccccaagtat tcagaagagt 1560  
ccaaattgaa tcgagaagaa atagacgggg tgaaactaga atcaatggga gtttatcaaa 1620  
ttttggcgat ctattccaca gtcgccagtt ctctagtctt gttagtctcc tggggggcaa 1680  
tcagcttctg gatgtgctct aatgggtcat tgcaatgcag aatatgcatt taa        1733  


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic amplification
      primer for ribonucleotide reductase (RR) domain and
      right-flanking region of Herpes simplex virus-2 (HSV-2)
      ribonucleotide reductase large subunit (ICP10, RR1)

<400> 13
acacgcccta tcatctgagg                                             20    


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic amplification
      primer for ribonucleotide reductase (RR) domain and
      right-flanking region of Herpes simplex virus-2 (HSV-2)
      ribonucleotide reductase large subunit (ICP10, RR1)

<400> 14
aacatgatga aggggcttcc                                             20    


<210> 15
<211> 502
<212> PRT
<213> human herpesvirus 2

<220> 
<223> Herpes simplex virus type 2 (HSV-2) ribonucleotide
      reductase (ICP10, RR1)

<220> 
<221> MOD_RES
<222> (280)
<223> Xaa = any amino acid

<400> 15
Met Ala Asn Arg Pro Ala Ala Ser Ala Leu Ala Gly Ala Arg Ser Pro  
  1               5                  10                  15    

Ser Glu Arg Gln Glu Pro Arg Glu Pro Glu Val Ala Pro Pro Gly Gly  
             20                  25                  30        

Asp His Val Phe Cys Arg Lys Val Ser Gly Val Met Val Leu Ser Ser  
         35                  40                  45            

Asp Pro Pro Gly Pro Ala Ala Tyr Arg Ile Ser Asp Ser Ser Phe Val  
     50                  55                  60                

Gln Cys Gly Ser Asn Cys Ser Met Ile Ile Asp Gly Asp Val Ala Arg  
 65                  70                  75                  80

Gly His Leu Arg Asp Leu Glu Gly Ala Thr Ser Thr Gly Ala Phe Val  
                 85                  90                  95    

Ala Ile Ser Asn Val Ala Ala Gly Gly Asp Gly Arg Thr Ala Val Val  
            100                 105                 110        

Ala Leu Gly Gly Thr Ser Gly Pro Ser Ala Thr Thr Ser Val Gly Thr  
        115                 120                 125            

Gln Thr Ser Gly Glu Phe Leu His Gly Asn Pro Arg Thr Pro Glu Pro  
    130                 135                 140                

Gln Gly Pro Gln Ala Val Pro Pro Pro Pro Pro Pro Pro Phe Pro Trp  
145                 150                 155                 160

Gly His Glu Cys Cys Ala Arg Arg Asp Ala Arg Gly Gly Ala Glu Lys  
                165                 170                 175    

Asp Val Gly Ala Ala Glu Ser Trp Ser Asp Gly Pro Ser Ser Asp Ser  
            180                 185                 190        

Glu Thr Glu Asp Ser Asp Ser Ser Asp Glu Asp Thr Gly Ser Gly Ser  
        195                 200                 205            

Glu Thr Leu Ser Arg Ser Ser Ser Ile Trp Ala Ala Gly Ala Thr Asp  
    210                 215                 220                

Asp Asp Asp Ser Asp Ser Asp Ser Arg Ser Asp Asp Ser Val Gln Pro  
225                 230                 235                 240

Asp Val Val Val Arg Arg Arg Trp Ser Asp Gly Pro Ala Pro Val Ala  
                245                 250                 255    

Phe Pro Lys Pro Arg Arg Pro Gly Asp Ser Pro Gly Asn Pro Gly Leu  
            260                 265                 270        

Gly Ala Ala Pro Gly Arg Ala Xaa Pro Arg Arg Thr Arg Ala Arg Arg  
        275                 280                 285            

Pro Thr Pro Ile Pro Ala His Ala Ala Ala Pro Gln Ala Asp Val Ala  
    290                 295                 300                

Pro Val Leu Asp Gly Gln Pro Thr Val Gly Thr Asp Pro Gly Tyr Pro  
305                 310                 315                 320

Val Pro Leu Glu Leu Thr Pro Glu Asn Ala Glu Ala Val Ala Arg Phe  
                325                 330                 335    

Leu Gly Asp Ala Val Asp Arg Glu Pro Ala Leu Met Leu Glu Tyr Phe  
            340                 345                 350        

Cys Arg Cys Ala Arg Glu Glu Ser Lys Arg Val Pro Pro Arg Thr Phe  
        355                 360                 365            

Gly Ser Ala Pro Arg Leu Thr Glu Asp Asp Phe Gly Leu Leu Asn Tyr  
    370                 375                 380                

Ala Leu Ala Glu Met Arg Arg Leu Cys Leu Asp Leu Pro Pro Val Pro  
385                 390                 395                 400

Pro Asn Ala Tyr Thr Pro Tyr His Leu Arg Glu Tyr Ala Thr Arg Leu  
                405                 410                 415    

Val Asn Gly Phe Lys Pro Leu Val Arg Arg Ser Ala Arg Leu Tyr Arg  
            420                 425                 430        

Ile Leu Gly Ile Leu Val His Leu Arg Ile Arg Thr Arg Glu Ala Ser  
        435                 440                 445            

Phe Glu Glu Trp Met Arg Ser Lys Glu Val Asp Leu Asp Phe Gly Leu  
    450                 455                 460                

Thr Glu Arg Leu Arg Glu His Glu Ala Gln Leu Met Ile Leu Ala Gln  
465                 470                 475                 480

Ala Leu Asn Pro Tyr Asp Cys Leu Ile His Ser Thr Pro Asn Thr Leu  
                485                 490                 495    

Val Glu Arg Gly Leu Gln                                          
            500        


<210> 16
<211> 323
<212> PRT
<213> Homo sapiens

<220>
<223> exemplary human CD47 (GenBank Accession No. Q08722.1 
      (GI:1171879)) 

<400> 16

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 


<210> 17
<211> 3429
<212> DNA
<213> human herpesvirus 2

<220> 
<223> Herpes simplex virus type 2 (HSV-2) ribonucleotide
      reductase (ICP10, RR1) wild-type gene

<400> 17
atggccaacc gccctgccgc atccgccctc gccggagcgc ggtctccgtc cgaacgacag 60    
gaaccccggg agcccgaggt cgccccccct ggcggcgacc acgtgttttg caggaaagtc 120   
agcggcgtga tggtgctttc cagcgatccc cccggccccg cggcctaccg cattagcgac 180   
agcagctttg ttcaatgcgg ctccaactgc agtatgataa tcgacggaga cgtggcgcgc 240   
ggtcatttgc gtgacctcga gggcgctacg tccaccggcg ccttcgtcgc gatctcaaac 300   
gtcgcagccg gcggggatgg ccgaaccgcc gtcgtggcgc tcggcggaac ctcgggcccg 360   
tccgcgacta catccgtggg gacccagacg tccggggagt tcctccacgg gaacccaagg 420   
acccccgaac cccaaggacc ccaggctgtc cccccgcccc ctcctccccc ctttccatgg 480   
ggccacgagt gctgcgcccg tcgcgatgcc aggggcggcg ccgagaagga cgtcggggcc 540   
gcggagtcat ggtcagacgg cccgtcgtcc gactccgaaa cggaggactc ggactcctcg 600   
gacgaggata cgggttcgga gacgctgtct cgatcctctt cgatctgggc cgcaggggcg 660   
actgacgacg atgacagcga ctccgactcg cggtcggacg actccgtgca gcccgacgtt 720   
gtcgttcgtc gcagatggag cgacggcccc gcccccgtgg cctttcccaa gccccggcgc 780   
cccggcgact cccccggaaa ccccggcctg ggcgccggca ccgggccggg ctccgcgacg 840   
gacccgcgcg cgtcggccga ctccgattcc gcggcccacg ccgccgcacc ccaggcggac 900   
gtggcgccgg ttctggacag ccagcccact gtgggaacgg accccggcta cccagtcccc 960   
ctagaactca cgcccgagaa cgcggaggcg gtggcgcggt ttctggggga cgccgtcgac 1020  
cgcgagcccg cgctcatgct ggagtacttc tgtcggtgcg cccgcgagga gagcaagcgc 1080  
gtgcccccac gaaccttcgg cagcgccccc cgcctcacgg aggacgactt tgggctcctg 1140  
aactacgcgc tcgctgagat gcgacgcctg tgcctggacc ttcccccggt cccccccaac 1200  
gcatacacgc cctatcatct gagggagtat gcgacgcggc tggttaacgg gttcaaaccc 1260  
ctggtgcggc ggtccgcccg cctgtatcgc atcctggggg ttctggtcca cctgcgcatc 1320  
cgtacccggg aggcctcctt tgaggaatgg atgcgctcca aggaggtgga cctggacttc 1380  
gggctgacgg aaaggcttcg cgaacacgag gcccagctaa tgatcctggc ccaggccctg 1440  
aacccctacg actgtctgat ccacagcacc ccgaacacgc tcgtcgagcg ggggctgcag 1500  
tcggcgctga agtacgaaga gttttacctc aagcgcttcg gcgggcacta catggagtcc 1560  
gtcttccaga tgtacacccg catcgccggg tttctggcgt gccgggcgac ccgcggcatg 1620  
cgccacatcg ccctggggcg acaggggtcg tggtgggaaa tgttcaagtt ctttttccac 1680  
cgcctctacg accaccagat cgtgccgtcc acccccgcca tgctgaacct cggaacccgc 1740  
aactactaca cgtccagctg ctacctggta aacccccagg ccaccactaa ccaggccacc 1800  
ctccgggcca tcaccggcaa cgtgagcgcc atcctcgccc gcaacggggg catcgggctg 1860  
tgcatgcagg cgttcaacga cgccagcccc ggcaccgcca gcatcatgcc ggccctgaag 1920  
gtcctcgact ccctggtggc ggcgcacaac aaacagagca cgcgccccac cggggcgtgc 1980  
gtgtacctgg aaccctggca cagcgacgtt cgggccgtgc tcagaatgaa gggcgtcctc 2040  
gccggcgagg aggcccagcg ctgcgacaac atcttcagcg ccctctggat gccggacctg 2100  
ttcttcaagc gcctgatccg ccacctcgac ggcgagaaaa acgtcacctg gtccctgttc 2160  
gaccgggaca ccagcatgtc gctcgccgac tttcacggcg aggagttcga gaagctgtac 2220  
gagcacctcg aggccatggg gttcggcgaa acgatcccca tccaggacct ggcgtacgcc 2280  
atcgtgcgca gcgcggccac caccggaagc cccttcatca tgtttaagga cgcggtaaac 2340  
cgccactaca tctacgacac gcaaggggcg gccatcgccg gctccaacct ctgcaccgag 2400  
atcgtccacc cggcctccaa gcgatccagt ggggtctgca acctgggaag cgtgaatctg 2460  
gcccgatgcg tctccaggca gacgtttgac tttgggcggc tccgcgacgc cgtgcaggcg 2520  
tgcgtgctga tggtgaacat catgatcgac agcacgctac aacccacgcc ccagtgcacc 2580  
cgcggcaacg acaacctgcg gtccatgggc attggcatgc agggcctgca cacggcgtgc 2640  
ctcaagatgg gcctggatct ggagtcggcc gagttccggg acctgaacac acacatcgcc 2700  
gaggtgatgc tgctcgcggc catgaagacc agtaacgcgc tgtgcgttcg cggggcgcgt 2760  
cccttcagcc actttaagcg cagcatgtac cgggccggcc gctttcactg ggagcgcttt 2820  
tcgaacgcca gcccgcggta cgagggcgag tgggagatgc tacgccagag catgatgaaa 2880  
cacggcctgc gcaacagcca gttcatcgcg ctcatgccca ccgccgcctc ggcccagatc 2940  
tcggacgtca gcgagggctt tgcccccctg ttcaccaacc tgttcagcaa ggtgaccagg 3000  
gacggcgaga cgctgcgccc caacacgctc ttgctgaagg aactcgagcg cacgttcggc 3060  
gggaagcggc tcctggacgc gatggacggg ctcgaggcca agcagtggtc tgtggcccag 3120  
gccctgcctt gcctggaccc cgcccacccc ctccggcggt tcaagacggc cttcgactac 3180  
gaccaggaac tgctgatcga cctgtgtgca gaccgcgccc cctatgttga tcacagccaa 3240  
tccatgactc tgtatgtcac agagaaggcg gacgggacgc tccccgcctc caccctggtc 3300  
cgccttctcg tccacgcata taagcgcggc ctgaagacgg ggatgtacta ctgcaaggtt 3360  
cgcaaggcga ccaacagcgg ggtgttcgcc ggcgacgaca acatcgtctg cacaagctgc 3420  
gcgctgtaa                                                         3429  


<210> 18
<211> 2961
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:modified Herpes simplex
      virus type 2 (HSV-2) ribonucleotide reductase (ICP10, RR1)
      gene with some amino-terminal serine/threonine protein kinase
      (PK) domain deleted

<400> 18
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac 60    
ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac 120   
ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc 180   
ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag 240   
cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc 300   
ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg 360   
gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac 420   
aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac 480   
ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc 540   
gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac 600   
tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc 660   
ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagagc 720   
ggccgcttaa ttaaccacac gccctatcat ctgagggagt atgcgacgcg gctggttaac 780   
gggttcaaac ccctggtgcg gcggtccgcc cgcctgtatc gcatcctggg ggttctggtc 840   
cacctgcgca tccgtacccg ggaggcctcc tttgaggaat ggatgcgctc caaggaggtg 900   
gacctggact tcgggctgac ggaaaggctt cgcgaacacg aggcccagct aatgatcctg 960   
gcccaggccc tgaaccccta cgactgtctg atccacagca ccccgaacac gctcgtcgag 1020  
cgggggctgc agtcggcgct gaagtacgaa gagttttacc tcaagcgctt cggcgggcac 1080  
tacatggagt ccgtcttcca gatgtacacc cgcatcgccg ggtttctggc gtgccgggcg 1140  
acccgcggca tgcgccacat cgccctgggg cgacaggggt cgtggtggga aatgttcaag 1200  
ttctttttcc accgcctcta cgaccaccag atcgtgccgt ccacccccgc catgctgaac 1260  
ctcggaaccc gcaactacta cacgtccagc tgctacctgg taaaccccca ggccaccact 1320  
aaccaggcca ccctccgggc catcaccggc aacgtgagcg ccatcctcgc ccgcaacggg 1380  
ggcatcgggc tgtgcatgca ggcgttcaac gacgccagcc ccggcaccgc cagcatcatg 1440  
ccggccctga aggtcctcga ctccctggtg gcggcgcaca acaaacagag cacgcgcccc 1500  
accggggcgt gcgtgtacct ggaaccctgg cacagcgacg ttcgggccgt gctcagaatg 1560  
aagggcgtcc tcgccggcga ggaggcccag cgctgcgaca acatcttcag cgccctctgg 1620  
atgccggacc tgttcttcaa gcgcctgatc cgccacctcg acggcgagaa aaacgtcacc 1680  
tggtccctgt tcgaccggga caccagcatg tcgctcgccg actttcacgg cgaggagttc 1740  
gagaagctgt acgagcacct cgaggccatg gggttcggcg aaacgatccc catccaggac 1800  
ctggcgtacg ccatcgtgcg cagcgcggcc accaccggaa gccccttcat catgtttaag 1860  
gacgcggtaa accgccacta catctacgac acgcaagggg cggccatcgc cggctccaac 1920  
ctctgcaccg agatcgtcca cccggcctcc aagcgatcca gtggggtctg caacctggga 1980  
agcgtgaatc tggcccgatg cgtctccagg cagacgtttg actttgggcg gctccgcgac 2040  
gccgtgcagg cgtgcgtgct gatggtgaac atcatgatcg acagcacgct acaacccacg 2100  
ccccagtgca cccgcggcaa cgacaacctg cggtccatgg gcattggcat gcagggcctg 2160  
cacacggcgt gcctcaagat gggcctggat ctggagtcgg ccgagttccg ggacctgaac 2220  
acacacatcg ccgaggtgat gctgctcgcg gccatgaaga ccagtaacgc gctgtgcgtt 2280  
cgcggggcgc gtcccttcag ccactttaag cgcagcatgt accgggccgg ccgctttcac 2340  
tgggagcgct tttcgaacgc cagcccgcgg tacgagggcg agtgggagat gctacgccag 2400  
agcatgatga aacacggcct gcgcaacagc cagttcatcg cgctcatgcc caccgccgcc 2460  
tcggcccaga tctcggacgt cagcgagggc tttgcccccc tgttcaccaa cctgttcagc 2520  
aaggtgacca gggacggcga gacgctgcgc cccaacacgc tcttgctgaa ggaactcgag 2580  
cgcacgttcg gcgggaagcg gctcctggac gcgatggacg ggctcgaggc caagcagtgg 2640  
tctgtggccc aggccctgcc ttgcctggac cccgcccacc ccctccggcg gttcaagacg 2700  
gccttcgact acgaccagga actgctgatc gacctgtgtg cagaccgcgc cccctatgtt 2760  
gatcacagcc aatccatgac tctgtatgtc acagagaagg cggacgggac gctccccgcc 2820  
tccaccctgg tccgccttct cgtccacgca tataagcgcg gcctgaagac ggggatgtac 2880  
tactgcaagg ttcgcaaggc gaccaacagc ggggtgttcg ccggcgacga caacatcgtc 2940  
tgcacaagct gcgcgctgta a                                           2961  


<210> 19
<211> 2247
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:modified Herpes simplex
      virus type 2 (HSV-2) ribonucleotide reductase (ICP10, RR1)
      gene with amino-terminal serine/threonine protein kinase
      (PK) domain deleted

<400> 19
atgagcggcc gcttaattaa ccacacgccc tatcatctga gggagtatgc gacgcggctg 60    
gttaacgggt tcaaacccct ggtgcggcgg tccgcccgcc tgtatcgcat cctgggggtt 120   
ctggtccacc tgcgcatccg tacccgggag gcctcctttg aggaatggat gcgctccaag 180   
gaggtggacc tggacttcgg gctgacggaa aggcttcgcg aacacgaggc ccagctaatg 240   
atcctggccc aggccctgaa cccctacgac tgtctgatcc acagcacccc gaacacgctc 300   
gtcgagcggg ggctgcagtc ggcgctgaag tacgaagagt tttacctcaa gcgcttcggc 360   
gggcactaca tggagtccgt cttccagatg tacacccgca tcgccgggtt tctggcgtgc 420   
cgggcgaccc gcggcatgcg ccacatcgcc ctggggcgac aggggtcgtg gtgggaaatg 480   
ttcaagttct ttttccaccg cctctacgac caccagatcg tgccgtccac ccccgccatg 540   
ctgaacctcg gaacccgcaa ctactacacg tccagctgct acctggtaaa cccccaggcc 600   
accactaacc aggccaccct ccgggccatc accggcaacg tgagcgccat cctcgcccgc 660   
aacgggggca tcgggctgtg catgcaggcg ttcaacgacg ccagccccgg caccgccagc 720   
atcatgccgg ccctgaaggt cctcgactcc ctggtggcgg cgcacaacaa acagagcacg 780   
cgccccaccg gggcgtgcgt gtacctggaa ccctggcaca gcgacgttcg ggccgtgctc 840   
agaatgaagg gcgtcctcgc cggcgaggag gcccagcgct gcgacaacat cttcagcgcc 900   
ctctggatgc cggacctgtt cttcaagcgc ctgatccgcc acctcgacgg cgagaaaaac 960   
gtcacctggt ccctgttcga ccgggacacc agcatgtcgc tcgccgactt tcacggcgag 1020  
gagttcgaga agctgtacga gcacctcgag gccatggggt tcggcgaaac gatccccatc 1080  
caggacctgg cgtacgccat cgtgcgcagc gcggccacca ccggaagccc cttcatcatg 1140  
tttaaggacg cggtaaaccg ccactacatc tacgacacgc aaggggcggc catcgccggc 1200  
tccaacctct gcaccgagat cgtccacccg gcctccaagc gatccagtgg ggtctgcaac 1260  
ctgggaagcg tgaatctggc ccgatgcgtc tccaggcaga cgtttgactt tgggcggctc 1320  
cgcgacgccg tgcaggcgtg cgtgctgatg gtgaacatca tgatcgacag cacgctacaa 1380  
cccacgcccc agtgcacccg cggcaacgac aacctgcggt ccatgggcat tggcatgcag 1440  
ggcctgcaca cggcgtgcct caagatgggc ctggatctgg agtcggccga gttccgggac 1500  
ctgaacacac acatcgccga ggtgatgctg ctcgcggcca tgaagaccag taacgcgctg 1560  
tgcgttcgcg gggcgcgtcc cttcagccac tttaagcgca gcatgtaccg ggccggccgc 1620  
tttcactggg agcgcttttc gaacgccagc ccgcggtacg agggcgagtg ggagatgcta 1680  
cgccagagca tgatgaaaca cggcctgcgc aacagccagt tcatcgcgct catgcccacc 1740  
gccgcctcgg cccagatctc ggacgtcagc gagggctttg cccccctgtt caccaacctg 1800  
ttcagcaagg tgaccaggga cggcgagacg ctgcgcccca acacgctctt gctgaaggaa 1860  
ctcgagcgca cgttcggcgg gaagcggctc ctggacgcga tggacgggct cgaggccaag 1920  
cagtggtctg tggcccaggc cctgccttgc ctggaccccg cccaccccct ccggcggttc 1980  
aagacggcct tcgactacga ccaggaactg ctgatcgacc tgtgtgcaga ccgcgccccc 2040  
tatgttgatc acagccaatc catgactctg tatgtcacag agaaggcgga cgggacgctc 2100  
cccgcctcca ccctggtccg ccttctcgtc cacgcatata agcgcggcct gaagacgggg 2160  
atgtactact gcaaggttcg caaggcgacc aacagcgggg tgttcgccgg cgacgacaac 2220  
atcgtctgca caagctgcgc gctgtaa                                     2247  


<210> 20
<211> 655
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:immediate early
      cytomegalovirus (CMV) constitutive promoter
      regulatory sequence

<400> 20
cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt aatagtaatc 60    
aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt 120   
aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta 180   
tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg 240   
gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga 300   
cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt 360   
tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg 420   
gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc 480   
cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg 540   
taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat 600   
aagcagagct ctctggctaa ctagagaacc cactgcttac tggcttatcg aaatt      655   


<210>  21
<211>  123
<212>  PRT
<213>  Homo sapiens

<220>
<223>  exemplary human CD47 excluding signal sequence

<400>  21

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu 
        115                 120             
