                         SEQUENCE LISTING

<110>  SYSTIMMUNE, INC.
       SICHUAN BAILI PHARMACEUTICAL CO. LTD.
 
<120>  RECOMBINANT ACE2-FC FUSION MOLECULES AND METHODS OF MAKING AND 
       USING THEREOF

<130>  SIBA202PCT

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  2
<211>  2418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct ccttttag                                                   2418


<210>  3
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp 
    610                 615 


<210>  4
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagac                     1845


<210>  5
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  6
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  7
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His 
    610                 615                 620                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
625                 630                 635                 640 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                645                 650                 655     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            660                 665                 670         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        675                 680                 685             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    690                 695                 700                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
705                 710                 715                 720 


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                725                 730                 735     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            740                 745                 750         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        755                 760                 765             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    770                 775                 780                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
785                 790                 795                 800 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                805                 810                 815     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            820                 825                 830         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 845         


<210>  8
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagcc caaatcttcc     1860

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc     1920

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1980

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2040

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2100

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2160

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2220

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     2280

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2340

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2400

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     2460

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2520

ctctccctgt ctccgggtaa atag                                            2544


<210>  9
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            740                 745                 750         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        835                 840                 


<210>  10
<211>  2535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagtc caaatatggt     1860

cccccgtgcc caccatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc     1920

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg     1980

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag     2040

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc     2100

agcgtcctca ccgtcctcca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc     2160

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     2220

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     2280

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     2340

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     2400

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     2460

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     2520

tctctgggta aatga                                                      2535


<210>  11
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Ser Gln Asp Val Thr Val Pro Cys Pro 
    610                 615                 620                 


Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
625                 630                 635                 640 


Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu 
                645                 650                 655     


Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr 
            660                 665                 670         


Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser 
        675                 680                 685             


Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys 
    690                 695                 700                 


Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His 
705                 710                 715                 720 


Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro 
                725                 730                 735     


Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val 
            740                 745                 750         


His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val 
        755                 760                 765             


Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val 
    770                 775                 780                 


Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr 
785                 790                 795                 800 


Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val 
                805                 810                 815     


Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr 
            820                 825                 830         


Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln 
        835                 840                 845             


Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser 
    850                 855                 860                 


Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
865                 870                 875 


<210>  12
<211>  2628
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacagcca ggatgtgact     1860

gtgccctgcc cagttccctc aactccacct accccatctc cctcaactcc acctacccca     1920

tctccctcat gctgccaccc ccgactgtca ctgcaccgac cggccctcga ggacctgctc     1980

ttaggttcag aagcgaacct cacgtgcaca ctgaccggcc tgagagatgc ctcaggtgtc     2040

accttcacct ggacgccctc aagtgggaag agcgctgttc aaggaccacc tgagcgtgac     2100

ctctgtggct gctacagcgt gtccagtgtc ctgccgggct gtgccgagcc atggaaccat     2160

gggaagacct tcacttgcac tgctgcctac cccgagtcca agaccccgct aaccgccacc     2220

ctctcaaaat ccggaaacac attccggccc gaggtccacc tgctgccgcc gccgtcggag     2280

gagctggccc tgaacgagct ggtgacgctg acgtgcctgg cacgcggctt cagccccaag     2340

gacgtgctgg ttcgctggct gcaggggtca caggagctgc cccgcgagaa gtacctgact     2400

tgggcatccc ggcaggagcc cagccagggc accaccacct tcgctgtgac cagcatactg     2460

cgcgtggcag ccgaggactg gaagaagggg gacaccttct cctgcatggt gggccacgag     2520

gccctgccgc tggccttcac acagaagacc atcgaccgct tggcgggtaa acccacccat     2580

gtcaatgtgt ctgttgtcat ggcggaggtg gacggcacct gctactga                  2628


<210>  13
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Ser Gln Asp Val Thr Val Pro Cys Arg 
    610                 615                 620                 


Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg 
625                 630                 635                 640 


Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys 
                645                 650                 655     


Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr 
            660                 665                 670         


Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
        675                 680                 685             


Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro 
    690                 695                 700                 


Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu 
705                 710                 715                 720 


Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg 
                725                 730                 735     


Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn 
            740                 745                 750         


Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp 
        755                 760                 765             


Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys 
    770                 775                 780                 


Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr 
785                 790                 795                 800 


Tyr Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys 
                805                 810                 815     


Gly Glu Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala 
            820                 825                 830         


Phe Thr Gln Lys Thr Ile Asp Arg Met Ala Gly Lys Pro Thr His Ile 
        835                 840                 845             


Asn Val Ser Val Val Met Ala Glu Ala Asp Gly Thr Cys Tyr 
    850                 855                 860         


<210>  14
<211>  2589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacagcca ggatgtgact     1860

gtgccctgcc gagttccccc acctccccca tgctgccacc cccgactgtc gctgcaccga     1920

ccggccctcg aggacctgct cttaggttca gaagcgaacc tcacgtgcac actgaccggc     1980

ctgagagatg cctctggtgc caccttcacc tggacgccct caagtgggaa gagcgctgtt     2040

caaggaccac ctgagcgtga cctctgtggc tgctacagcg tgtccagtgt cctgcctggc     2100

tgtgcccagc catggaacca tggggagacc ttcacctgca ctgctgccca ccccgagttg     2160

aagaccccac taaccgccaa catcacaaaa tccggaaaca cattccggcc cgaggtccac     2220

ctgctgccgc cgccgtcgga ggagctggcc ctgaacgagc tggtgacgct gacgtgcctg     2280

gcacgtggct tcagccccaa ggatgtgctg gttcgctggc tgcaggggtc acaggagctg     2340

ccccgcgaga agtacctgac ttgggcatcc cggcaggagc ccagccaggg caccaccacc     2400

tatgctgtga ccagcatact gcgcgtggca gccgaggact ggaagaaggg ggaaaccttc     2460

tcctgcatgg tgggccacga ggccctgccg ctggccttca cacagaagac catcgaccgc     2520

atggcgggta aacccaccca tatcaatgtg tctgttgtca tggcggaggc ggacggcacc     2580

tgctactga                                                             2589


<210>  15
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        595                 600                 605             


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
    610                 615                 620                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
625                 630                 635                 640 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                645                 650                 655     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            660                 665                 670         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        675                 680                 685             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    690                 695                 700                 


Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
705                 710                 715                 720 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                725                 730                 735     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            740                 745                 750         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        755                 760                 765             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    770                 775                 780                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
785                 790                 795                 800 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                805                 810                 815     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825                 830 


<210>  16
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
        595                 600                 605             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    610                 615                 620                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
625                 630                 635                 640 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                645                 650                 655     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            660                 665                 670         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        675                 680                 685             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    690                 695                 700                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
705                 710                 715                 720 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                725                 730                 735     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            740                 745                 750         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        755                 760                 765             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    770                 775                 780                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
785                 790                 795                 800 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                805                 810                 815     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            820                 825         


<210>  17
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Ser Gln Asp Val Thr Val Pro Cys Pro Val 
        595                 600                 605             


Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
    610                 615                 620                 


Pro Ser Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu 
625                 630                 635                 640 


Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly 
                645                 650                 655     


Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly 
            660                 665                 670         


Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr 
        675                 680                 685             


Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly 
    690                 695                 700                 


Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu 
705                 710                 715                 720 


Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His 
                725                 730                 735     


Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr 
            740                 745                 750         


Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg 
        755                 760                 765             


Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp 
    770                 775                 780                 


Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr 
785                 790                 795                 800 


Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe 
                805                 810                 815     


Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys 
            820                 825                 830         


Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val 
        835                 840                 845             


Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
    850                 855             


<210>  18
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Ser Gln Asp Val Thr Val Pro Cys Arg Val 
        595                 600                 605             


Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg Pro 
    610                 615                 620                 


Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr 
625                 630                 635                 640 


Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro 
                645                 650                 655     


Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys 
            660                 665                 670         


Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp 
        675                 680                 685             


Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys 
    690                 695                 700                 


Thr Pro Leu Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg Pro 
705                 710                 715                 720 


Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu 
                725                 730                 735     


Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val 
            740                 745                 750         


Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr 
        755                 760                 765             


Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Tyr 
    770                 775                 780                 


Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly 
785                 790                 795                 800 


Glu Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe 
                805                 810                 815     


Thr Gln Lys Thr Ile Asp Arg Met Ala Gly Lys Pro Thr His Ile Asn 
            820                 825                 830         


Val Ser Val Val Met Ala Glu Ala Asp Gly Thr Cys Tyr 
        835                 840                 845 


<210>  19
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His 
    610                 615                 620                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
625                 630                 635                 640 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                645                 650                 655     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            660                 665                 670         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        675                 680                 685             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    690                 695                 700                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
705                 710                 715                 720 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                725                 730                 735     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            740                 745                 750         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        755                 760                 765             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    770                 775                 780                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
785                 790                 795                 800 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                805                 810                 815     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            820                 825                 830         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 845         


<210>  20
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agctccagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagacgagcc caaatcttcc     1860

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1920

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1980

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     2040

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     2100

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     2160

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     2220

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     2280

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     2340

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     2400

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     2460

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     2520

ctctccctgt ctccgggtaa atag                                            2544


<210>  21
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            740                 745                 750         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        755                 760                 765             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    770                 775                 780                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
785                 790                 795                 800 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                805                 810                 815     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            820                 825                 830         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        835                 840                 845             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    850                 855                 860                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
865                 870                 875                 880 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                885                 890                 895     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            900                 905                 910         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        915                 920                 925             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    930                 935                 940                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
945                 950                 955                 960 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                965                 970         


<210>  22
<211>  2919
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agctccagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     2280

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     2340

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     2400

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     2460

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     2520

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     2580

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     2640

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     2700

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     2760

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     2820

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     2880

tacacgcaga agagcctctc cctgtctccg ggtaaatag                            2919


<210>  23
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp His His His His His His 
    610                 615                 620     


<210>  24
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccatca tcaccatcac     1860

cac                                                                   1863


<210>  25
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Trp Lys Phe Met Gly Ser Lys Cys Ser Asn Ser Gly 
            20                  25                  30          


Ile Glu Cys Asp Ser Ser Gly Thr Cys Ile Asn Pro Ser Asn Trp Cys 
        35                  40                  45              


Asp Gly Val Ser His Cys Pro Gly Gly Glu Asp Glu Asn Arg Cys Val 
    50                  55                  60                  


Arg Leu Tyr Gly Pro Asn Phe Ile Leu Gln Val Tyr Ser Ser Gln Arg 
65                  70                  75                  80  


Lys Ser Trp His Pro Val Cys Gln Asp Asp Trp Asn Glu Asn Tyr Gly 
                85                  90                  95      


Arg Ala Ala Cys Arg Asp Met Gly Tyr Lys Asn Asn Phe Tyr Ser Ser 
            100                 105                 110         


Gln Gly Ile Val Asp Asp Ser Gly Ser Thr Ser Phe Met Lys Leu Asn 
        115                 120                 125             


Thr Ser Ala Gly Asn Val Asp Ile Tyr Lys Lys Leu Tyr His Ser Asp 
    130                 135                 140                 


Ala Cys Ser Ser Lys Ala Val Val Ser Leu Arg Cys Ile Ala Cys Gly 
145                 150                 155                 160 


Val Asn Leu Asn Ser Ser Arg Gln Ser Arg Ile Val Gly Gly Glu Ser 
                165                 170                 175     


Ala Leu Pro Gly Ala Trp Pro Trp Gln Val Ser Leu His Val Gln Asn 
            180                 185                 190         


Val His Val Cys Gly Gly Ser Ile Ile Thr Pro Glu Trp Ile Val Thr 
        195                 200                 205             


Ala Ala His Cys Val Glu Lys Pro Leu Asn Asn Pro Trp His Trp Thr 
    210                 215                 220                 


Ala Phe Ala Gly Ile Leu Arg Gln Ser Phe Met Phe Tyr Gly Ala Gly 
225                 230                 235                 240 


Tyr Gln Val Glu Lys Val Ile Ser His Pro Asn Tyr Asp Ser Lys Thr 
                245                 250                 255     


Lys Asn Asn Asp Ile Ala Leu Met Lys Leu Gln Lys Pro Leu Thr Phe 
            260                 265                 270         


Asn Asp Leu Val Lys Pro Val Cys Leu Pro Asn Pro Gly Met Met Leu 
        275                 280                 285             


Gln Pro Glu Gln Leu Cys Trp Ile Ser Gly Trp Gly Ala Thr Glu Glu 
    290                 295                 300                 


Lys Gly Lys Thr Ser Glu Val Leu Asn Ala Ala Lys Val Leu Leu Ile 
305                 310                 315                 320 


Glu Thr Gln Arg Cys Asn Ser Arg Tyr Val Tyr Asp Asn Leu Ile Thr 
                325                 330                 335     


Pro Ala Met Ile Cys Ala Gly Phe Leu Gln Gly Asn Val Asp Ser Cys 
            340                 345                 350         


Gln Gly Asp Ser Gly Gly Pro Leu Val Thr Ser Lys Asn Asn Ile Trp 
        355                 360                 365             


Trp Leu Ile Gly Asp Thr Ser Trp Gly Ser Gly Cys Ala Lys Ala Tyr 
    370                 375                 380                 


Arg Pro Gly Val Tyr Gly Asn Val Met Val Phe Thr Asp Trp Ile Tyr 
385                 390                 395                 400 


Arg Gln Met Arg Ala Asp Gly His His His His His His 
                405                 410             


<210>  26
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt caccaattcg       60

tggaagttta tgggttctaa atgctctaat agcgggatag aatgtgacag tagtggcact      120

tgcattaacc cttcaaactg gtgtgatggg gtaagccatt gccccggggg ggaagatgaa      180

aatagatgtg ttaggctcta cggtcccaac tttatactcc aggtatattc aagtcaacgc      240

aaatcatggc atccagtgtg tcaagacgac tggaacgaaa actatggacg cgctgcatgt      300

cgagatatgg gatataagaa taacttctat agttcacagg gaatcgtaga tgactctgga      360

tctactagtt tcatgaaact gaacacctct gccggaaacg tagatatata taaaaagctt      420

taccactccg acgcttgtag ctctaaggcc gtagttagcc tcagatgcat cgcctgcgga      480

gtaaacctca attcatctcg ccagagtagg atcgttggcg gggaaagcgc cctcccaggc      540

gcttggcctt ggcaagtttc ccttcatgtc cagaatgttc atgtatgtgg cgggtctata      600

atcaccccag aatggatcgt cacagctgcc cactgcgtgg agaaacccct caacaatcct      660

tggcattgga ccgcatttgc cggaatactg agacaatcat ttatgttcta tggagccggg      720

taccaagtcg aaaaggtcat ttcccatccc aattatgatt ccaaaaccaa aaacaatgac      780

atagccttga tgaaactcca gaagcctttg acatttaatg acctggtcaa accagtgtgc      840

ctcccaaatc ctggaatgat gttgcagcct gaacagttgt gctggatcag cggttggggt      900

gctaccgagg agaagggtaa gacaagcgag gtccttaacg ctgcaaaggt tttgctgata      960

gaaacacaga gatgtaacag ccgctatgtg tacgataacc tgatcacccc agctatgatt     1020

tgcgccgggt ttttgcaagg taacgtcgat tcttgccaag gtgactcagg cggccctctt     1080

gttacatcaa agaacaatat atggtggctt atcggcgata catcatgggg ttctggatgt     1140

gctaaagcct atcgcccagg ggtgtatggc aatgtaatgg tgtttacaga ctggatctat     1200

aggcagatgc gggctgacgg tcaccatcat caccatcact ga                        1242


<210>  27
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  28
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28

Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu Gly Asn 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn Arg His 
            20                  25                  30          


Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys Ile Thr 
        35                  40                  45              


Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly Arg Ala 
    50                  55                  60                  


Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn Ile Ala 
65                  70                  75                  80  


Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu Gly Ile 
                85                  90                  95      


Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser Gln Gly 
            100                 105                 110         


Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu Gly Arg 
        115                 120                 125             


Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln Lys Arg 
    130                 135                 140                 


Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val Ile Asp 
145                 150                 155                 160 


Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg Leu Asp 
                165                 170                 175     


Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn Gln Leu 
            180                 185                 190         


Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp Asp Ser 
        195                 200                 205             


Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro Glu Pro 
    210                 215                 220                 


Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His Cys Ala 
225                 230                 235                 240 


Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg Gln Ser 
                245                 250                 255     


Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys Arg Ala 
            260                 265                 270         


Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys Asp Gly 
        275                 280                 285             


Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala Gly Arg 
    290                 295                 300                 


Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly Ser Pro 
305                 310                 315                 320 


Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile Pro Arg 
                325                 330                 335     


Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala Val Leu 
            340                 345                 350         


Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp Cys Leu 
        355                 360                 365             


Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp Ser Glu 
    370                 375                 380                 


Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu Glu Glu 
385                 390                 395                 400 


Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr Ser Arg 
                405                 410                 415     


Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu Trp Arg 
            420                 425                 430         


Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu Lys Val 
        435                 440                 445             


Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val Pro Cys 
    450                 455                 460                 


His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys Lys Trp 
465                 470                 475                 480 


Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly Pro Ser 
                485                 490                 495     


Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser Leu Thr 
            500                 505                 510         


Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys Gly Val 
        515                 520                 525             


Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val Ala Val 
    530                 535                 540                 


Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala Lys Ala 
545                 550                 555                 560 


Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg Glu Ile 
                565                 570                 575     


Glu Asn Lys Ala Ile Gln Asp Pro Arg 
            580                 585 


