                         SEQUENCE LISTING

<110>  Sirnaomics, Inc.

<120>  TARGETED NUCLEIC ACID THERAPY FOR HEPATITIS B

<130>  4690.0036i

<140>  PCT/US22/13425
<141>  2022-01-21

<150>  US 63/140,232
<151>  2021-01-21

<160>  104

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  1
gguucuucug gacuaucaad tdt                                               23


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  2
uugauagucc agaagaaccd tdt                                               23


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  3
cgcuugggac ucucucgucd tdt                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  4
gacgagagag ucccaagcgd tdt                                               23


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  5
cgcagucccc aaccuccaad tdt                                               23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  6
uuggagguug gggacugcgd tdt                                               23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  7
ccaaccuccu guccuccaad tdt                                               23


<210>  8
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial sequence

<400>  8
uuggaggaca ggagguuggd tdt                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  9
guccugguua ucgcuggaud tdt                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  10
auccagcgau aaccaggacd tdt                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  11
ccucuucauc cugcugcuad tdt                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  12
uagcagcagg augaagaggd tdt                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  13
cugcugcuau gccucaucud tdt                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  14
agaugaggca uagcagcagd tdt                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  15
gacgcaaccc ccacuggcud tdt                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  16
agccaguggg gguugcgucd tdt                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  17
cucucguccc cuucuccgud tdt                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  18
acggagaagg ggacgagagd tdt                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  19
gggcuuuccc ccacuguuud tdt                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  20
aaacaguggg ggaaagcccd tdt                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  21
ccuauugauu ggaaaguaud tdt                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  22
auacuuucca aucaauaggd tdt                                               23


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  23
gcagucccca accuccaauc acuca                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  24
ugagugauug gagguugggg acugc                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  25
guccccaacc uccaaucacu cacca                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  26
uggugaguga uuggagguug gggac                                             25


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  27
ccaaccucca aucacucacc aaccu                                             25


<210>  28
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  28
agguugguga gugauuggag guugg                                             25


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  29
guccugguua ucgcuggaug ugucu                                             25


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  30
agacacaucc agcgauaacc aggac                                             25


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  31
cucuucaucc ugcugcuaug ccuca                                             25


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  32
ugaggcauag cagcaggaug aagag                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  33
guugcccguu uguccucuaa uucca                                             25


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  34
uggaauuaga ggacaaacgg gcaac                                             25


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  35
gugcacuucg cuucaccucu gcacg                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  36
cgugcagagg ugaagcgaag ugcac                                             25


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  37
ccugcuggug gcuccaguud tdt                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  38
aacuggagcc accagcaggd tdt                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  39
cagcaauguc aacgaccgad tdt                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  40
ucggucguug acauugcugd tdt                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  41
ccuuggacuc auaagguggd tdt                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  42
ccaccuuaug aguccaaggd tdt                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  43
gguggagccc ucaggcucad tdt                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  44
ugagccugag ggcuccaccd tdt                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  45
cagucaggaa ggcagccuad tdt                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  46
uaggcugccu uccugacugd tdt                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  47
gguggcucca guucaggaad tdt                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  48
uuccugaacu ggagccaccd tdt                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  49
guugacaaga auccucacad tdt                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  50
ugugaggauu cuugucaacd tdt                                               23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  51
gacaagaauc cucacaauad tdt                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  52
uauugugagg auucuugucd tdt                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  53
cuagacucgu gguggacuud tdt                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  54
aaguccacca cgagucuagd tdt                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  55
gagauuaggu uaaaggucud tdt                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  56
agaccuuuaa ccuaaucucd tdt                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  57
gcauaaauug gucugcgcad tdt                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  58
ugcgcagacc aauuuaugcd tdt                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  59
gcgcaccagc accaugcaad tdt                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  60
uugcauggug cuggugcgcd tdt                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  61
ccucugccua aucaucucud tdt                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  62
agagaugauu aggcagaggd tdt                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  63
cacuuccgga aacuacugud tdt                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  64
acaguaguuu ccggaagugd tdt                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  65
cccucaggcu cagggcauad tdt                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  66
uaugcccuga gccugagggd tdt                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  67
cgaggcaggu ccccuagaad tdt                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  68
uucuagggga ccugccucgd tdt                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  69
gggaaucuca auguuaguad tdt                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  70
uacuaacauu gagauucccd tdt                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  71
ggaaucucaa uguuaguaud tdt                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  72
auacuaacau ugagauuccd tdt                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  73
caucacauca ggauuccuad tdt                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  74
uaggaauccu gaugugaugd tdt                                               23


<210>  75
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  75
gaacauggag aacaucacau cagga                                             25


<210>  76
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  76
uccugaugug auguucucca uguu                                              24


<210>  77
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  77
ggagaacauc acaucaggau uccua                                             25


<210>  78
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  78
uaggaauccu gaugugaugu ucucc                                             25


<210>  79
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  79
gaacaucaca ucaggauucc uagga                                             25


<210>  80
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  80
uccuaggaau ccugauguga uguuc                                             25


<210>  81
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  81
cuuguugaca agaauccuca caaua                                             25


<210>  82
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  82
uauugugagg auucuuguca acaag                                             25


<210>  83
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  83
cagagucuag acucguggug gacuu                                             25


<210>  84
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  84
aaguccacca cgagucuaga cucug                                             25


<210>  85
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  85
gagucuagac ucguggugga cuucu                                             25


<210>  86
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  86
agaaguccac cacgagucua gacuc                                             25


<210>  87
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  87
gucuagacuc gugguggacu ucucu                                             25


<210>  88
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  88
agagaagucc accacgaguc uagac                                             25


<210>  89
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  89
gcauggagac caccgugaac gccca                                             25


<210>  90
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  90
ugggcguuca cgguggucuc caugc                                             25


<210>  91
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  91
cuguaggcau aaauuggucu gcgca                                             25


<210>  92
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  92
ugcgcagacc aauuuaugcc uacag                                             25


<210>  93
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  93
gcauaaauug gucugcgcac cagca                                             25


<210>  94
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  94
ugcuggugcg cagaccaauu uaugc                                             25


<210>  95
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  95
gccuugggug gcuuuggggc augga                                             25


<210>  96
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  96
uccaugcccc aaagccaccc aaggc                                             25


<210>  97
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  97
gaauuuggag cuacugugga guuac                                             25


<210>  98
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  98
guaacuccac aguagcucca aauuc                                             25


<210>  99
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  99
cuccaguuca ggaacaguaa acccu                                             25


<210>  100
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  100
aggguuuacu guuccugaac uggag                                             25


<210>  101
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  101
ccugagcauu gcucaccuca ccaua                                             25


<210>  102
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  102
uauggugagg ugagcaaugc ucagg                                             25


<210>  103
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  103
ccaccaaucg gcagucagga aggca                                             25


<210>  104
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  104
ugccuuccug acugccgauu ggugg                                             25


<210>  105
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, f= 2'-fluoro, m = 2'-OMe

<400>  105
mCmGmCmAmG mUfCfCfCmC mAmAmCmCmU mCmCmAmAdT dT                          42


<210>  106
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  106
PmUfUmGmGm AmGmGmUmUm GmGmGmGfAm CmUmGmCmGd TdT                         43



<210>  107
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence f= 2'-fluoro, m = 2'-OMe

<400>  107
mCmCmUmCmU mUfCfAfUmC mCmUmGmCmU mGmCmUmAdT dT                           42


<210>  108
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  108
PmUfAmGmCm AmGmCmAmGm GmAmUmGfAm AmGmAmGmGd TdT                          43



<210>  109
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, f= 2'-fluoro, m = 2'-OMe

<400>  109
mCmUmCmUmC mGfUfCfCmC mCmUmUmCmU mCmCmGmUdT dT                           42



<210>  110
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  110
PmAfCmGmGm AmGmAmAmGm GmGmGmAfCm GmAmGmAmGd TdT                           43



<210>  111
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, f= 2'-fluoro, m = 2'-OMe

<400>  111
mCmCmUmAmU mUfGfAfUmU mGmGmAmAmA mGmUmAmUdT dT                             42



<210>  112
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  112
PmAfUmAmCm UmUmUmCmCm AmAmUmCfAm AmUmAmGmGd TdT                            43



<210>  113
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, f= 2'-fluoro, m = 2'-OMe

<400>  113
mGmCmAmUmA mAfAfUfUmG mGmUmCmUmG mCmGmCmAdT dT                             42



<210>  114
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  114
PmUfGmCmGm CmAmGmAmCm CmAmAmUfUm UmAmUmGmCd TdT                            43



<210>  115
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, f= 2'-fluoro, m = 2'-OMe

<400>  115
mCmCmAmAmC mCmUmCmCmA mAmUfCfAfC mUmCmAmCmC mAmAmCmCmU                     50



<210>  116
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  116
PmAfGmGmUm UmGmGmUmGm AmGmUmGfAm UmUmGmGmAm GmGmUmUmGm G                   51



<210>  117
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, f= 2'-fluoro, m = 2'-OMe

<400>  117
mCmUmGmUmA mGmGmCmAmU mAmAfAfUfU mGmGmUmCmU mGmCmGmCmA                     50




<210>  118
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial and modified sequence, p=phosphate moiety, f= 2'-fluoro, m = 2'-OMe

<400>  118
PmUfGmCmGm CmAmGmAmCm CmAmAmUfUm UmAmUmGmCm CmUmAmCmAm G                   51





