                         SEQUENCE LISTING

<110>  UCL Business Ltd
 
<120>  Gene Therapy For Dopamine Transporter Deficiency Syndrome

<130>  P529425PC00

<150>  GB2101958.3
<151>  2021-02-12

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human synapsin 1 promoter, truncated version

<400>  1
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct c                          401


<210>  2
<211>  422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human synapsin 1 promoter with 5' extension

<400>  2
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tc                                                                     422


<210>  3
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human synapsin 1 promoter with 3' extension

<400>  3
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  4
<211>  851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eSYN promoter

<400>  4
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gctgcagagg gccctgcgta tgagtgcaag tgggttttag      420

gaccaggatg aggcggggtg ggggtgccta cctgacgacc gaccccgacc cactggacaa      480

gcacccaacc cccattcccc aaattgcgca tcccctatca gagaggggga ggggaaacag      540

gatgcggcga ggcgcgtcgc gactgccagc ttcagcaccg cggacagtgc cttcgccccc      600

gcctggcggc gcgcgccacc gccgcctcag cactgaaggc gcgctgacgt cactcgccgg      660

tcccccgcaa actccccttc ccggccacct tggtcgcgtc cgcgccgccg ccggcccagc      720

cggaccgcac cacgcgaggc gcgagatagg ggggcacggg cgcgaccatc tgcgctgcgg      780

cgccggcgac tcagcgctgc ctcagtctgc ggtgggcagc ggaggagtcg tgtcgtgcct      840

gagagcgcag g                                                           851


<210>  5
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human beta-actin promoter

<400>  5
gcccagcacc ccaaggcggc caacgccaaa actctccctc ctcctcttcc tcaatctcgc       60

tctcgctctt tttttttttc gcaaaaggag gggagagggg gtaaaaaaat gctgcactgt      120

gcggcgaagc cggtgagtga gcggcgcggg gccaatcagc gtgcgccgtt ccgaaagttg      180

ccttttatgg ctcgagcggc cgcggcggcg ccctataaaa cccagcggcg cgacgcgcca      240

ccaccgccga gtc                                                         253


<210>  6
<211>  281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chicken beta-actin promoter

<400>  6
ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct ccccaccccc       60

aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg a                          281


<210>  7
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  7
acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat       60

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      120

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      180

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      240

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga      300

ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt      360

gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg      420

cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg      480

cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc      540

ggccctataa aaagcgaagc gcgcggcggg cgg                                   573


<210>  8
<211>  220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter

<400>  8
tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat       60

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      120

actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac      180

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg                            220


<210>  9
<211>  583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter (second version)

<400>  9
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgt                        583


<210>  10
<211>  281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CAMKII promoter

<400>  10
acttgtggac aaagtttgct ctattccacc tcctccaggc cctccttggg tccatcaccc       60

caggggtgct gggtccatcc cacccccagg cccacacagg cttgcagtat tgtgtgcggt      120

atggtcaggg cgtccgagag caggtttcgc agtggaaggc aggcaggtgt tggggaggca      180

gttaccgggg caacgggaac agggcgtttt ggaggtggtt gccatgggga cctggatgct      240

gacgaaggct cgcgaggctg tgagcagcca cagtgccctg c                          281


<210>  11
<211>  455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human EF1-alpha promoter

<400>  11
caacctttgg agctaagcca gcaatggtag agggaagatt ctgcacgtcc cttccaggcg       60

gcctccccgt caccaccccc cccaacccgc cccgaccgga gctgagagta attcatacaa      120

aaggactcgc ccctgccttg gggaatccca gggaccgtcg ttaaactccc actaacgtag      180

aacccagaga tcgctgcgtt cccgccccct cacccgcccg ctctcgtcat cactgaggtg      240

gagaatagca tgcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag      300

tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga aggtggcgcg      360

gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag      420

aaccgtatat aagtgcagta gtcgccgtga acgtt                                 455


<210>  12
<211>  2120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human SLC6A3 gene

<400>  12
atgagtaaga gcaaatgctc cgtgggactc atgtcttccg tggtggcccc ggctaaggag       60

cccaatgccg tgggcccgaa ggaggtggag ctcatccttg tcaaggagca gaacggagtg      120

cagctcacca gctccaccct caccaacccg cggcagagcc ccgtggaggc ccaggatcgg      180

gagacctggg gcaagaagat cgactttctc ctgtccgtca ttggctttgc tgtggacctg      240

gccaacgtct ggcggttccc ctacctgtgc tacaaaaatg gtggcggtgc cttcctggtc      300

ccctacctgc tcttcatggt cattgctggg atgccacttt tctacatgga gctggccctc      360

ggccagttca acagggaagg ggccgctggt gtctggaaga tctgccccat actgaaaggt      420

gtgggcttca cggtcatcct catctcactg tatgtcggct tcttctacaa cgtcatcatc      480

gcctgggcgc tgcactatct cttctcctcc ttcaccacgg agctcccctg gatccactgc      540

aacaactcct ggaacagccc caactgctcg gatgcccatc ctggtgactc cagtggagac      600

agctcgggcc tcaacgacac ttttgggacc acacctgctg ccgagtactt tgaacgtggc      660

gtgctgcacc tccaccagag ccatggcatc gacgacctgg ggcctccgcg gtggcagctc      720

acagcctgcc tggtgctggt catcgtgctg ctctacttca gcctctggaa gggcgtgaag      780

acctcaggga aggtggtatg gatcacagcc accatgccat acgtggtcct cactgccctg      840

ctcctgcgtg gggtcaccct ccctggagcc atagacggca tcagagcata cctgagcgtt      900

gacttctacc ggctctgcga ggcgtctgtt tggattgacg cggccaccca ggtgtgcttc      960

tccctgggcg tggggttcgg ggtgctgatc gccttctcca gctacaacaa gttcaccaac     1020

aactgctaca gggacgcgat tgtcaccacc tccatcaact ccctgacgag cttctcctcc     1080

ggcttcgtcg tcttctcctt cctggggtac atggcacaga agcacagtgt gcccatcggg     1140

gacgtggcca aggacgggcc agggctgatc ttcatcatct acccggaagc catcgccacg     1200

ctccctctgt cctcagcctg ggccgtggtc ttcttcatca tgctgctcac cctgggtatc     1260

gacagcgcca tgggtggtat ggagtcagtg atcaccgggc tcatcgatga gttccagctg     1320

ctgcacagac accgtgagct cttcacgctc ttcatcgtcc tggcgacctt cctcctgtcc     1380

ctgttctgcg tcaccaacgg tggcatctac gtcttcacgc tcctggacca ttttgcagcc     1440

ggcacgtcca tcctctttgg agtgctcatc gaagccatcg gagtggcctg gttctatggt     1500

gttgggcagt tcagcgacga catccagcag atgaccgggc agcggcccag cctgtactgg     1560

cggctgtgct ggaagctggt cagcccctgc tttctcctgt tcgtggtcgt ggtcagcatt     1620

gtgaccttca gaccccccca ctacggagcc tacatcttcc ccgactgggc caacgcgctg     1680

ggctgggtca tcgccacatc ctccatggcc atggtgccca tctatgcggc ctacaagttc     1740

tgcagcctgc ctgggtcctt tcgagagaaa ctggcctacg ccattgcacc cgagaaggac     1800

cgtgagctgg tggacagagg ggaggtgcgc cagttcacgc tccgccactg gctcaaggtg     1860

tagagggagc agagacgaag accccaggaa gtcatcctgc aatgggagag acacgaacaa     1920

accaaggaaa tctaagtttc gagagaaagg agggcaactt ctactcttca acctctactg     1980

aaaacacaaa caacaaagca gaagactcct ctcttctgac tgtttacacc tttccgtgcc     2040

gggagcgcac ctcgccgtgt cttgtgttgc tgtaataacg acgtagatct gtgcagcgag     2100

gtccaccccg ttgttgtccc                                                 2120


<210>  13
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human DAT protein

<400>  13

Met Ser Lys Ser Lys Cys Ser Val Gly Leu Met Ser Ser Val Val Ala 
1               5                   10                  15      


Pro Ala Lys Glu Pro Asn Ala Val Gly Pro Lys Glu Val Glu Leu Ile 
            20                  25                  30          


Leu Val Lys Glu Gln Asn Gly Val Gln Leu Thr Ser Ser Thr Leu Thr 
        35                  40                  45              


Asn Pro Arg Gln Ser Pro Val Glu Ala Gln Asp Arg Glu Thr Trp Gly 
    50                  55                  60                  


Lys Lys Ile Asp Phe Leu Leu Ser Val Ile Gly Phe Ala Val Asp Leu 
65                  70                  75                  80  


Ala Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly 
                85                  90                  95      


Ala Phe Leu Val Pro Tyr Leu Leu Phe Met Val Ile Ala Gly Met Pro 
            100                 105                 110         


Leu Phe Tyr Met Glu Leu Ala Leu Gly Gln Phe Asn Arg Glu Gly Ala 
        115                 120                 125             


Ala Gly Val Trp Lys Ile Cys Pro Ile Leu Lys Gly Val Gly Phe Thr 
    130                 135                 140                 


Val Ile Leu Ile Ser Leu Tyr Val Gly Phe Phe Tyr Asn Val Ile Ile 
145                 150                 155                 160 


Ala Trp Ala Leu His Tyr Leu Phe Ser Ser Phe Thr Thr Glu Leu Pro 
                165                 170                 175     


Trp Ile His Cys Asn Asn Ser Trp Asn Ser Pro Asn Cys Ser Asp Ala 
            180                 185                 190         


His Pro Gly Asp Ser Ser Gly Asp Ser Ser Gly Leu Asn Asp Thr Phe 
        195                 200                 205             


Gly Thr Thr Pro Ala Ala Glu Tyr Phe Glu Arg Gly Val Leu His Leu 
    210                 215                 220                 


His Gln Ser His Gly Ile Asp Asp Leu Gly Pro Pro Arg Trp Gln Leu 
225                 230                 235                 240 


Thr Ala Cys Leu Val Leu Val Ile Val Leu Leu Tyr Phe Ser Leu Trp 
                245                 250                 255     


Lys Gly Val Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Met 
            260                 265                 270         


Pro Tyr Val Val Leu Thr Ala Leu Leu Leu Arg Gly Val Thr Leu Pro 
        275                 280                 285             


Gly Ala Ile Asp Gly Ile Arg Ala Tyr Leu Ser Val Asp Phe Tyr Arg 
    290                 295                 300                 


Leu Cys Glu Ala Ser Val Trp Ile Asp Ala Ala Thr Gln Val Cys Phe 
305                 310                 315                 320 


Ser Leu Gly Val Gly Phe Gly Val Leu Ile Ala Phe Ser Ser Tyr Asn 
                325                 330                 335     


Lys Phe Thr Asn Asn Cys Tyr Arg Asp Ala Ile Val Thr Thr Ser Ile 
            340                 345                 350         


Asn Ser Leu Thr Ser Phe Ser Ser Gly Phe Val Val Phe Ser Phe Leu 
        355                 360                 365             


Gly Tyr Met Ala Gln Lys His Ser Val Pro Ile Gly Asp Val Ala Lys 
    370                 375                 380                 


Asp Gly Pro Gly Leu Ile Phe Ile Ile Tyr Pro Glu Ala Ile Ala Thr 
385                 390                 395                 400 


Leu Pro Leu Ser Ser Ala Trp Ala Val Val Phe Phe Ile Met Leu Leu 
                405                 410                 415     


Thr Leu Gly Ile Asp Ser Ala Met Gly Gly Met Glu Ser Val Ile Thr 
            420                 425                 430         


Gly Leu Ile Asp Glu Phe Gln Leu Leu His Arg His Arg Glu Leu Phe 
        435                 440                 445             


Thr Leu Phe Ile Val Leu Ala Thr Phe Leu Leu Ser Leu Phe Cys Val 
    450                 455                 460                 


Thr Asn Gly Gly Ile Tyr Val Phe Thr Leu Leu Asp His Phe Ala Ala 
465                 470                 475                 480 


Gly Thr Ser Ile Leu Phe Gly Val Leu Ile Glu Ala Ile Gly Val Ala 
                485                 490                 495     


Trp Phe Tyr Gly Val Gly Gln Phe Ser Asp Asp Ile Gln Gln Met Thr 
            500                 505                 510         


Gly Gln Arg Pro Ser Leu Tyr Trp Arg Leu Cys Trp Lys Leu Val Ser 
        515                 520                 525             


Pro Cys Phe Leu Leu Phe Val Val Val Val Ser Ile Val Thr Phe Arg 
    530                 535                 540                 


Pro Pro His Tyr Gly Ala Tyr Ile Phe Pro Asp Trp Ala Asn Ala Leu 
545                 550                 555                 560 


Gly Trp Val Ile Ala Thr Ser Ser Met Ala Met Val Pro Ile Tyr Ala 
                565                 570                 575     


Ala Tyr Lys Phe Cys Ser Leu Pro Gly Ser Phe Arg Glu Lys Leu Ala 
            580                 585                 590         


Tyr Ala Ile Ala Pro Glu Lys Asp Arg Glu Leu Val Asp Arg Gly Glu 
        595                 600                 605             


Val Arg Gln Phe Thr Leu Arg His Trp Leu Lys Val 
    610                 615                 620 


<210>  14
<211>  293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV immediate early enhancer

<400>  14
acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat       60

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      120

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      180

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      240

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta cca             293


<210>  15
<211>  512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPL-eMLP adenovirus derived enhancer element

<400>  15
ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca       60

aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac      120

tccgccaccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa      180

ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg      240

gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt      300

gagacggcgg atggtcgagg tgaggtgtgg caggcttgag atccagctgt tggggtgagt      360

actccctctc aaaagcgggc attacttctg cgctaagatt gtcagtttcc aaaaacgagg      420

aggatttgat attcacctgg cccgatctgg ccatacactt gagtgacaat gacatccact      480

ttgcctttct ctccacaggt gtccactccc ag                                    512


<210>  16
<211>  476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta-globin intron

<400>  16
gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca      240

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata      300

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc      360

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga      420

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacag          476


<210>  17
<211>  953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human beta-actin exon/intron

<400>  17
cgcgtccgcc cgcgagcaca gagcctcgcc tttgccgatc cgccgcccgt ccacacccgc       60

cgccaggtaa gcccggccag ccgaccgggg catgcggccg cggcccttcg cccgtgcaga      120

gccgccgtct gggccgcagc ggggggcgca tggggcggaa ccggaccgcc gtggggggcg      180

cgggagaagc ccctgggcct ccggagatgg gggacacccc acgccagttc gcaggcgcga      240

ggccgcgctc gggcgggcgc gctccggggg tgccgctctc ggggcggggg caaccggcgg      300

ggtctttgtc tgagccgggc tcttgccaat ggggatcgca cggtgggcgc ggcgtagccc      360

ccgtcaggcc cggtgggggc tggggcgcca tgcgcgtgcg cgctggtcct ttgggcgcta      420

actgcgtgcg cgctgggaat tggcgctaat tgcgcgtgcg cgctgggact caatggcgct      480

aatcgcgcgt gcgttctggg gcccgggcgc ttgcgccact tcctgcccga gccgctggcg      540

cccgagggtg tggccgctgc gtgcgcgcgc gcgacccggt cgctgtttga accgggcgga      600

ggcggggctg gcgcccggtt gggagggggt tggggcctgg cttcctgccg cgcgccgcgg      660

ggacgcctcc gaccagtgtt tgccttttat ggtaataacg cggccggccc ggcttccttt      720

gtccccaatc tgggcgcgcg ccggcgcccc ctggcggcct aaggactcgg cgcgccggaa      780

gtggccaggg cggcagcggc tgctcttggc ggccccgagg tgactatagc cttcttttgt      840

gtcttgatag ttcgccagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc      900

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttc             953


<210>  18
<211>  956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF1-alpha intron/exon

<400>  18
ctttttcgca acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg       60

cctggcctct ttacgggtta tggcccttgc gtgccttgaa ttacttccac ctggctccag      120

tacgtgattc ttgatcccga gctggagcca ggggcgggcc ttgcgcttta ggagcccctt      180

cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt      240

ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat      300

gacgtgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caggatctgc      360

acactggtat ttcggttttt gggcccgcgg ccggcgacgg ggcccgtgcg tcccagcgca      420

catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc      480

aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg      540

cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc      600

ctgctccagg gggctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac      660

ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt      720

accgggcgcc gtccaggcac ctcgattagt tctggagctt ttggagtacg tcgtctttag      780

gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag      840

ttaggccagc ttggcacttg atgtaattct ccttggaatt tggccttttt gagtttggat      900

cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcag          956


<210>  19
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human EF1-alpha, intron A

<400>  19
gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg       60

ccttgaatta cttccacctg gctgcagtac gtgattcttg atcccgagct tcgggttgga      120

agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt      180

gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt      240

ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt      300

tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt      360

tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg      420

ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct      480

ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg      540

tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca      600

aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg      660

gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg      720

cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt      780

tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac      840

ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag      900

cctcagacag tggttcaaag tttttttctt ccatttcag                             939


<210>  20
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chicken beta-actin exon/intron + rabbit globin intron

<400>  20
gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc       60

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      120

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      180

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg      240

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc      300

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc      360

ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc      420

gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc      480

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc      540

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg      600

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc      660

tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag      720

ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc      780

tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc      840

cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg      900

ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc      960

ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg     1020

ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattc                  1068


<210>  21
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV IE exon

<400>  21
tcagatcgcc tggagaggcc atccacgctg ttttgacctc catagtggac accgggaccg       60

atccagcctc cgcggccggg aacggtgcat tggaacgcgg attccccgtg ccaagagtga      120

c                                                                      121


<210>  22
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' UTR-Syn1 Hs

<400>  22
agtctgcggt gggcagcgga ggagtcgtgt cgtgcctgag agcgcagctg tgctcctggg       60

caccgcgcag tccgcccccg cggctcctgg ccagaccacc cctaggaccc cctgccccaa      120

gtcgca                                                                 126


<210>  23
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' UTR human CamKIIa

<400>  23
tcagaagccc cgggctcgtc agtcaaaccg gttctctgtt tgcactcggc agcacgggca       60

ggcaagtggt ccctaggttc ggg                                               83


<210>  24
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  24
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  25
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR second version

<400>  25
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgta                   168


<210>  26
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  26
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  27
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR second version

<400>  27
tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag       60

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      120

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgc                   168


<210>  28
<211>  4214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 hSyn1 SLC6A3 vector construct

<400>  28
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcaatt cagtcgataa ctataacggt cctaaggtag      180

cgatttaaat acgcgctctc ttaaggtagc cccgggacgc gtcaattgac tacaaaccga      240

gtatctgcag agggccctgc gtatgagtgc aagtgggttt taggaccagg atgaggcggg      300

gtgggggtgc ctacctgacg accgaccccg acccactgga caagcaccca acccccattc      360

cccaaattgc gcatccccta tcagagaggg ggaggggaaa caggatgcgg cgaggcgcgt      420

gcgcactgcc agcttcagca ccgcggacag tgccttcgcc cccgcctggc ggcgcgcgcc      480

accgccgcct cagcactgaa ggcgcgctga cgtcactcgc cggtcccccg caaactcccc      540

ttcccggcca ccttggtcgc gtccgcgccg ccgccggccc agccggaccg caccacgcga      600

ggcgcgagat aggggggcac gggcgcgacc atctgcgctg cggcgccggc gactcagcgc      660

tgcctcagtc tgcggtgggc agcggaggag tcgtgtcgtg cctgagagcg cagctgtgct      720

cctgggcacc gcgcagtccg cccccgcggc tcctggccag accaccccta ggaccccctg      780

ccccaagtcg cagccttcga gctagcgttt aaacttaagc ttggtaccga gctcggatcc      840

actagtccag tgtggtggaa ttcctcaact cccagtgtgc ccatgagtaa gagcaaatgc      900

tccgtgggac tcatgtcttc cgtggtggcc ccggctaagg agcccaatgc cgtgggcccg      960

aaggaggtgg agctcatcct tgtcaaggag cagaacggag tgcagctcac cagctccacc     1020

ctcaccaacc cgcggcagag ccccgtggag gcccaggatc gggagacctg gggcaagaag     1080

atcgactttc tcctgtccgt cattggcttt gctgtggacc tggccaacgt ctggcggttc     1140

ccctacctgt gctacaaaaa tggtggcggt gccttcctgg tcccctacct gctcttcatg     1200

gtcattgctg ggatgccact tttctacatg gagctggccc tcggccagtt caacagggaa     1260

ggggccgctg gtgtctggaa gatctgcccc atactgaaag gtgtgggctt cacggtcatc     1320

ctcatctcac tgtatgtcgg cttcttctac aacgtcatca tcgcctgggc gctgcactat     1380

ctcttctcct ccttcaccac ggagctcccc tggatccact gcaacaactc ctggaacagc     1440

cccaactgct cggatgccca tcctggtgac tccagtggag acagctcggg cctcaacgac     1500

acttttggga ccacacctgc tgccgagtac tttgaacgtg gcgtgctgca cctccaccag     1560

agccatggca tcgacgacct ggggcctccg cggtggcagc tcacagcctg cctggtgctg     1620

gtcatcgtgc tgctctactt cagcctctgg aagggcgtga agacctcagg gaaggtggta     1680

tggatcacag ccaccatgcc atacgtggtc ctcactgccc tgctcctgcg tggggtcacc     1740

ctccctggag ccatagacgg catcagagca tacctgagcg ttgacttcta ccggctctgc     1800

gaggcgtctg tttggattga cgcggccacc caggtgtgct tctccctggg cgtggggttc     1860

ggggtgctga tcgccttctc cagctacaac aagttcacca acaactgcta cagggacgcg     1920

attgtcacca cctccatcaa ctccctgacg agcttctcct ccggcttcgt cgtcttctcc     1980

ttcctggggt acatggcaca gaagcacagt gtgcccatcg gggacgtggc caaggacggg     2040

ccagggctga tcttcatcat ctacccggaa gccatcgcca cgctccctct gtcctcagcc     2100

tgggccgtgg tcttcttcat catgctgctc accctgggta tcgacagcgc catgggtggt     2160

atggagtcag tgatcaccgg gctcatcgat gagttccagc tgctgcacag acaccgtgag     2220

ctcttcacgc tcttcatcgt cctggcgacc ttcctcctgt ccctgttctg cgtcaccaac     2280

ggtggcatct acgtcttcac gctcctggac cattttgcag ccggcacgtc catcctcttt     2340

ggagtgctca tcgaagccat cggagtggcc tggttctatg gtgttgggca gttcagcgac     2400

gacatccagc agatgaccgg gcagcggccc agcctgtact ggcggctgtg ctggaagctg     2460

gtcagcccct gctttctcct gttcgtggtc gtggtcagca ttgtgacctt cagacccccc     2520

cactacggag cctacatctt ccccgactgg gccaacgcgc tgggctgggt catcgccaca     2580

tcctccatgg ccatggtgcc catctatgcg gcctacaagt tctgcagcct gcctgggtcc     2640

tttcgagaga aactggccta cgccattgca cccgagaagg accgtgagct ggtggacaga     2700

ggggaggtgc gccagttcac gctccgccac tggctcaagg tgtagaggga gcagagacga     2760

agaccccagg aagtcatcct gcaatgggag agacacgaac aaaccaagga aatctaagtt     2820

tcgagagaaa ggagggcaac ttctactctt caacctctac tgaaaacaca aacaacaaag     2880

cagaagactc ctctcttctg actgtttaca cctttccgtg ccgggagcgc acctcgccgt     2940

gtcttgtgtt gctgtaataa cgacgtagat ctgtgcagcg aggtccaccc cgttgttgtc     3000

ccatccagca cagtggcggc cgctcgagtc tagagggccc ttcgaaggta agcctatccc     3060

taaccctctc ctcggtctcg attctacgcg taccggttaa tcgataatca acctctggat     3120

tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt     3180

ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc     3240

tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg     3300

caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc     3360

accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa     3420

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat     3480

tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg tgttgccacc     3540

tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt     3600

ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag     3660

acgagtcgga tctccctttg ggccgcctcc ccgcatcgaa acccgctgat cagccggtca     3720

tcatcaccat caccattgag tttaaacccg ctgatcagcc tcgactgtgc cttctagttg     3780

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     3840

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     3900

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     3960

gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gatcctctct     4020

taaggtagca tcgagattta aattagggat aacagggtaa tggcgcgggc cgcaggaacc     4080

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     4140

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     4200

cagctgcctg cagg                                                       4214


