                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  A VIRUS-ENCODED microRNA FOR USE IN THE DIAGNOSIS, PROGNOSIS AND 
       TREATMENT OF SARS-CoV-2 INFECTION AND ASSOCIATED DISEASE

<130>  B2006268EPWO

<150>  EP 21305192.3
<151>  2021-02-15

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  human coronavirus SARS-CoV-2

<400>  1
uucuuggcac ugauaacacu cg                                                22


<210>  2
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  2
uuuucuuggc acugauaaca cu                                                22


<210>  3
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  3
acaucuacug auuggacuag cu                                                22


<210>  4
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  4
gugcguggau gaggcugguu cu                                                22


<210>  5
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  5
uugcaauuua gguggugcug uc                                                22


<210>  6
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  6
aacaaugcua gggagagcug cc                                                22


<210>  7
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  7
gaagggagca gaggcggcag uc                                                22


<210>  8
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  8
uucaccgagg ccacgcggag ua                                                22


<210>  9
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  9
ucgaucucuu guagaucugu uc                                                22


<210>  10
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  10
acaacaacuc uggaagaaac ua                                                22


<210>  11
<211>  24
<212>  RNA
<213>  Human coronavirus SARS-CoV

<400>  11
uuuucuuggc acugauaaca cucg                                              24


<210>  12
<211>  24
<212>  RNA
<213>  Bat Coronavirus RmYN02

<400>  12
uuuucuuggc auugauaaca cuug                                              24


<210>  13
<211>  24
<212>  RNA
<213>  Human coronavirus SARS-CoV

<400>  13
ucuuccugac auugauugua uuua                                              24


<210>  14
<211>  70
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  14
augaaaauua uucuuuucuu ggcacugaua acacucgcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  15
<211>  70
<212>  RNA
<213>  Pangolin coronavirus MP789

<400>  15
augaaaauua uucuuuucuu ggcauugaua acacuugcua cuugugagcu uuaucauuau       60

caagagugug                                                              70


<210>  16
<211>  70
<212>  RNA
<213>  Bat coronavirus RmYN02

<400>  16
augaaaauua uucuuuucuu ggcauugaua acacuugcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  17
<211>  70
<212>  RNA
<213>  Bat coronavirus RaTG13

<400>  17
augaaaauua uucuuuucuu gguacuggua acacuugcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  18
<211>  70
<212>  RNA
<213>  Bat coronavirus ZXC21

<400>  18
augaaaauua uuuucuucuu gguacugaua acacuuguua cuggcgagcu uuaccacuac       60

caagagugua                                                              70


<210>  19
<211>  70
<212>  RNA
<213>  Bat coronavirus CoV ZC45

<400>  19
augaaaauua uuuucuucuu gguacugaua acacuuguua cuggcgagcu uuaccacuac       60

caagagugua                                                              70


<210>  20
<211>  70
<212>  RNA
<213>  Bat coronavirus CoV WIV1

<400>  20
augaaaauua uucucuuccu gacauugauu gcacuugcau cuugcgagcu auaucacuau       60

caggagugug                                                              70


<210>  21
<211>  70
<212>  RNA
<213>  Human coronavirus SARS-CoV

<400>  21
augaaaauua uucucuuccu gacauugauu guauuuacau cuugcgagcu auaucacuau       60

caggagugug                                                              70


<210>  22
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  22
gagaaaagug ccaacagaca au                                                22


<210>  23
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  23
cagucgcuac aggauuggca ac                                                22


<210>  24
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  24
agucauaguc aguuaggugg uu                                                22


<210>  25
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  25
uuucuuggca cugauaacac uc                                                22


<210>  26
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  26
guaguguuuu cagugccaag aa                                                22


<210>  27
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligoribonucleotide (BATF2 3'UTR)

<400>  27
aguguuuuca gugccaagaa gc                                                22


<210>  28
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligoribonucleotide (LAMP3 3'UTR)

<400>  28
cuguagagca gccugccaag aa                                                22


<210>  29
<211>  22
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  29
ugcacugacu ugcuuuagca cu                                                22


<210>  30
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

(RT primer miR-let7a-5p)

<400>  30
ctcaactggt gtcgtggagt cggcaattca gttgagaact atac                        44


<210>  31
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

(RT primer CoV2-miR-7a.1)

<400>  31
ctcaactggt gtcgtggagt cggcaattca gttgagagtg ttat                        44


<210>  32
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

(RT primer CoV2-miR-7a.2)

<400>  32
ctcaactggt gtcgtggagt cggcaattca gttgagcgag tgtt                        44


<210>  33
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

(RT primer vsRNA-ORF6 (vsRNA_27296))

<400>  33
ctcaactggt gtcgtggagt cggcaattca gttgagattt ttaa                        44


<210>  34
<211>  44
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

(RT primer for sRNA spike in)

<400>  34
ctcaactggt gtcgtggagt cggcaattca gttgagatta aatc                        44


<210>  35
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide

(Reverse Universal for small RNAs

<400>  35
ctcaagtgtc gtggagtcgg caa                                               23


<210>  36
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Forward miR-let7a-5p)

<400>  36
acactccagc tgggtgaggt agtaggttgt                                        30


<210>  37
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Forward primer CoV2-miR-7a.1)

<400>  37
acactccagc tgggttttct tggcactgat                                        30


<210>  38
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Forward primer CoV2-miR-7a.2)

<400>  38
acactccagc tgggttcttg gcactgataa                                        30


<210>  39
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Forward primer vsRNA-ORF6 
       (vsRNA_27296))

<400>  39
acactccagc tgggatcata aacctcataa                                        30


<210>  40
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Forward primer for sRNA spike in)

<400>  40
acactccagc tggggagagc agtggctggt                                        30


<210>  41
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (BATF2 F)

<400>  41
agaccccaag gagcaaca                                                     18


<210>  42
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (BATF2 R)

<400>  42
cagggcgagg ttgtcttt                                                     18


<210>  43
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Human GAPDH F)

<400>  43
gtctcctctg acttcaacag cg                                                22


<210>  44
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (Human GAPDH R)

<400>  44
accaccctgt tgctgtagcc aa                                                22


<210>  45
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (PNPT1 F)

<400>  45
gcatctgcat gtggcggaag tt                                                22


<210>  46
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (PNPT1 R)

<400>  46
ccttctcagg atcggttttg gtg                                               23


<210>  47
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (XAF1 F)

<400>  47
cctccatgag gcttactgcc tg                                                22


<210>  48
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (XAF1 R)

<400>  48
gaaactccag cgaggacttc tg                                                22


<210>  49
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (OAS2 F)

<400>  49
acccgaacag ttccccctgg t                                                 21


<210>  50
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (OAS2 R)

<400>  50
acaagggtac catcggagtt gcc                                               23


<210>  51
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (IFIT1 F)

<400>  51
ggacaggaag ctgaaggag                                                    19


<210>  52
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (IFIT1 R)

<400>  52
agtgggtgtt tcctg                                                        15


<210>  53
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (IFIT3 F)

<400>  53
tgccaaacag atgtcctccg c                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (IFIT3 R)

<400>  54
gccttgtagc agcacccaat c                                                 21


<210>  55
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (LAMP3 F)

<400>  55
ttggtctgac atcaaggtct tt                                                22


<210>  56
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (LAMP3 R)

<400>  56
gtatgctggt atgaggtgtg ag                                                22


<210>  57
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (DICER1 F)

<400>  57
catgcctcct accactacaa tac                                               23


<210>  58
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (DICER1 R)

<400>  58
ggtgcttggt tatgaggtag tc                                                22


<210>  59
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide (ERCC-00130 FWD Set 2)

<400>  59
attcgccata gaagccgata c                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic oligonucleotide( ERCC-00130 REV Set 2)

<400>  60
gcggttgaac catgttgatt t                                                 21


<210>  61
<211>  27
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligoribonucleotide (sRNA spike in oligo)

<400>  61
gagagcagug gcugguugag auuuaau                                           27


<210>  62
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligoribonucleotide (mimic control)

<400>  62
aacauacgag ggcaauucac c                                                 21


<210>  63
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide (antimiRNA antisense)

<400>  63
cgagtgttat cagtgccaag aaaa                                              24


<210>  64
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  64
tggaattctc gggtgccaag g                                                 21


<210>  65
<211>  70
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  65
augaaaauua uucuucucuu ggcacugaua acacucgcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  66
<211>  70
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  66
augaaaauug uucuuuucuu ggcacugaua acacucgcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  67
<211>  70
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  67
augaaaauua uuuuuuucuu ggcacugaua acacucgcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  68
<211>  70
<212>  RNA
<213>  Human coronavirus SARS-CoV-2

<400>  68
augaaaauua uucuuuucuu ggcauugaua acacucgcua cuugugagcu uuaucacuac       60

caagagugug                                                              70


<210>  69
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide (3'UTR CoV2-miR07a.2 site)

<400>  69
cgaguguuau cagugccaag aa                                                22


<210>  70
<211>  22
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide (3'UTR CoV2-miR07a.2 site mutant)

<400>  70
cgaguguuau cagucugcug uc                                                22


<210>  71
<211>  53
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (pre-CoV2-miR-O7a)

<400>  71
uucuuggcac ugauaacacu cgcuacuugu gagcuuuauc acuaccaaga gug              53


<210>  72
<211>  53
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (pre-CoV2-miR-O7a mutated)

<400>  72
uucuuggcac ugauaacacu cgcuacuucg cugcaauaag acuaccauca gug              53


<210>  73
<211>  60
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (hsa-miR21)

<400>  73
uagcuuauca gacugauguu gacuguugaa ucucauggca acaccagucg augggcugug       60


