                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum Stiftung des ffentlichen Rechts
       Universitt Heidelberg
       Universittsklinikum Mannheim GmbH  
 
<120>  nANGPTL-4 as marker for disease progression

<130>  DK16292PC

<150>  EP21156649.2
<151>  2021-02-11

<160>  4   

<170>  PatentIn version 3.5

<210>  1
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Val Gln Ser Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met 
1               5                   10                  15      


Asn Val Leu Ala His Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu 
            20                  25                  30          


His Ala Glu Arg Thr Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu 
        35                  40                  45              


Ser Ala Cys Gly Ser Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu 
    50                  55                  60                  


Pro Leu Ala Pro Glu Ser Arg Val Asp Pro Glu Val Leu His Ser Leu 
65                  70                  75                  80  


Gln Thr Gln Leu Lys Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His 
                85                  90                  95      


Lys Val Ala Gln Gln Gln Arg His Leu Glu Lys Gln His Leu Arg Ile 
            100                 105                 110         


Gln His Leu Gln Ser Gln Phe Gly Leu Leu Asp His Lys His Leu Asp 
        115                 120                 125             


His Glu Val Ala Lys Pro Ala 
    130                 135 


<210>  2
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Gly Arg Pro Ala Gln Pro Glu Pro Pro Arg Phe Ala Ser Trp Asp 
1               5                   10                  15      


Glu Met Asn Leu Leu Ala His Gly Leu Leu Gln Leu Gly His Gly Leu 
            20                  25                  30          


Arg Glu His Val Glu Arg Thr Arg Gly Gln Leu Gly Ala Leu Glu Arg 
        35                  40                  45              


Arg Met Ala Ala Cys Gly Asn Ala Cys Gln Gly Pro Lys Gly Lys Asp 
    50                  55                  60                  


Ala Pro Phe Lys Asp Ser Glu Asp Arg Val Pro Glu Gly Gln Thr Pro 
65                  70                  75                  80  


Glu Thr Leu Gln Ser Leu Gln Thr Gln Leu Lys Ala Gln Asn Ser Lys 
                85                  90                  95      


Ile Gln Gln Leu Phe Gln Lys Val Ala Gln Gln Gln Arg Tyr Leu Ser 
            100                 105                 110         


Lys Gln Asn Leu Arg Ile Gln Asn Leu Gln Ser Gln Ile Asp Leu Leu 
        115                 120                 125             


Ala Pro Thr His Leu Asp Asn Gly Val Asp Lys Thr Ser 
    130                 135                 140     


<210>  3
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  4
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Pro Val Gln Ser Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met 
1               5                   10                  15      


Asn Val Leu Ala His Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu 
            20                  25                  30          


His Ala Glu Arg Thr Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu 
        35                  40                  45              


Ser Ala Cys Gly Ser Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu 
    50                  55                  60                  


Pro Leu Ala Pro Glu Ser Arg Val Asp Pro Glu Val Leu His Ser Leu 
65                  70                  75                  80  


Gln Thr Gln Leu Lys Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His 
                85                  90                  95      


Lys Val Ala Gln Gln Gln Arg His Leu Glu Lys Gln His Leu Arg Ile 
            100                 105                 110         


Gln His Leu Gln Ser Gln Phe Gly Leu Leu Asp His Lys His Leu Asp 
        115                 120                 125             


His Glu Val Ala Lys Pro Ala Arg Arg Lys Arg Leu Pro Glu Met Ala 
    130                 135                 140                 


Gln Pro Val Asp Pro Ala His Asn Val Ser Arg Leu His Arg Leu Pro 
145                 150                 155                 160 


Arg Asp Cys Gln Glu Leu Phe Gln Val Gly Glu Arg Gln Ser Gly Leu 
                165                 170                 175     


Phe Glu Ile Gln Pro Gln Gly Ser Pro Pro Phe Leu Val Asn Cys Lys 
            180                 185                 190         


Met Thr Ser Asp Gly Gly Trp Thr Val Ile Gln Arg Arg His Asp Gly 
        195                 200                 205             


Ser Val Asp Phe Asn Arg Pro Trp Glu Ala Tyr Lys Ala Gly Phe Gly 
    210                 215                 220                 


Asp Pro His Gly Glu Phe Trp Leu Gly Leu Glu Lys Val His Ser Ile 
225                 230                 235                 240 


Thr Gly Asp Arg Asn Ser Arg Leu Ala Val Gln Leu Arg Asp Trp Asp 
                245                 250                 255     


Gly Asn Ala Glu Leu Leu Gln Phe Ser Val His Leu Gly Gly Glu Asp 
            260                 265                 270         


Thr Ala Tyr Ser Leu Gln Leu Thr Ala Pro Val Ala Gly Gln Leu Gly 
        275                 280                 285             


Ala Thr Thr Val Pro Pro Ser Gly Leu Ser Val Pro Phe Ser Thr Trp 
    290                 295                 300                 


Asp Gln Asp His Asp Leu Arg Arg Asp Lys Asn Cys Ala Lys Ser Leu 
305                 310                 315                 320 


Ser Gly Gly Trp Trp Phe Gly Thr Cys Ser His Ser Asn Leu Asn Gly 
                325                 330                 335     


Gln Tyr Phe Arg Ser Ile Pro Gln Gln Arg Gln Lys Leu Lys Lys Gly 
            340                 345                 350         


Ile Phe Trp Lys Thr Trp Arg Gly Arg Tyr Tyr Pro Leu Gln Ala Thr 
        355                 360                 365             


Thr Met Leu Ile Gln Pro Met Ala Ala Glu Ala Ala Ser 
    370                 375                 380     

