б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  PD-L1弰;

<130>  0134-PA-027

<160>  63

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  1

Gly Phe Thr Phe Ser Asn Phe 
1               5           


<210>  2
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  2

Thr His Ser Gly Gly Ile 
1               5       


<210>  3
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  3

Asp Pro Thr Glu Ala Pro Phe Asp Tyr 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  4

Gln Ala Ser Gln Asn Ile Asn Asn Tyr Ile Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  5

Tyr Thr Ser Thr Leu Val Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  6

Leu Gln Tyr Asp Asn Val Pro Asn Thr 
1               5                   


<210>  7
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 H-FR1

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH21910G2HzH31910G2HzH41910G2HzH71910G2HzH9 H-FR1

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  9
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 H-FR2

<400>  9

Trp Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210>  10
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH21910G2HzH41910G2HzH7 H-FR2

<400>  10

Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210>  11
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH31910G2HzH9 H-FR2

<400>  11

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210>  12
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 H-FR3

<400>  12

Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ala Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu 
            20                  25                  30          


Asp Thr Ala Thr Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  13
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH2 H-FR3

<400>  13

Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ala Lys Ser Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  14
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH3 H-FR3

<400>  14

Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  15
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH4 H-FR3

<400>  15

Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  16
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH7 H-FR3

<400>  16

Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  17
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH9 H-FR3

<400>  17

Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  18
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-31910G2HzH3 H-FR4

<400>  18

Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH21910G2HzH41910G2HzH71910G2HzH9 H-FR4

<400>  19

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  20
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  21
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH2 VH

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  22
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH3 VH

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  23
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH4 VH

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  24
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH7 VH

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  25
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH9 VH

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  26
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR1

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Thr Ile Thr Cys 
            20              


<210>  27
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL21910G2HzL31910G2HzL9 L-FR1

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  28
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR2

<400>  28

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Gln Leu Ile Arg 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL21910G2HzL31910G2HzL9 L-FR2

<400>  29

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile Arg 
1               5                   10                  15  


<210>  30
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR3

<400>  30

Gly Thr Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Ser 
1               5                   10                  15      


Phe Ser Ile Ser Asn Val Glu Ser Glu Asp Ile Ala Ser Tyr Tyr Cys 
            20                  25                  30          


<210>  31
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL2 L-FR3

<400>  31

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  32
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL3 L-FR3

<400>  32

Gly Thr Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr 
1               5                   10                  15      


Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  33
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL9 L-FR3

<400>  33

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  34
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR4

<400>  34

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL21910G2HzL31910G2HzL9 L-FR4

<400>  35

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  36
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 VL

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  37
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL2 VL

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  38
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL3 VL

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Phe Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL9 VL

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  40

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  41
<211>  330
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  㶨

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  42
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH2

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  43
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH3

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  44
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH4

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  45
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH7

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  46
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzH9

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  47
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL2

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  48
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL3

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Phe Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  49
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910G2HzL9

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  50
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 H-FR1; 1910G2HzH21910G2HzH31910G2HzH41910G2HzH71910G2HzH9 H-FR1

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaVal

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Ala Ser 
            20                  25  


<210>  51
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 H-FR2; 1910G2HzH21910G2HzH41910G2HzH7 H-FR2; 1910G2HzH31910G2HzH9 H-FR2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = IleVal

<400>  51

Trp Met Xaa Trp Xaa Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210>  52
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 H-FR3; 1910G2HzH2 H-FR3; 1910G2HzH3 H-FR3; 1910G2HzH4 H-FR3; 1910G2HzH7 H-FR3; 1910G2HzH9 H-FR3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaProVal

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = ThrVal

<400>  52

Thr Tyr Tyr Xaa Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Xaa Xaa Lys Xaa Xaa Leu Tyr Leu Gln Met Asn Ser Leu Arg Xaa Glu 
            20                  25                  30          


Asp Thr Ala Xaa Tyr Tyr Cys Ser Arg 
        35                  40      


<210>  53
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-31910G2HzH3 H-FR4; 1910G2HzH21910G2HzH41910G2HzH71910G2HzH9 H-FR4

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuMet

<400>  53

Trp Gly Gln Gly Xaa Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  54
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 VH; 1910G2HzH2 VH; 1910G2HzH3 VH; 1910G2HzH4 VH; 1910G2HzH7 VH; 1910G2HzH9 VH

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa = AlaProVal

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa = LeuMet

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Xaa Trp Xaa Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr His Ser Gly Gly Ile Thr Tyr Tyr Xaa Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Xaa Lys Xaa Xaa Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Asp Pro Thr Glu Ala Pro Phe Asp Tyr Trp Gly Gln Gly Xaa 
            100                 105                 110         


Xaa Val Thr Val Ser Ser 
        115             


<210>  55
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR1; 1910G2HzL21910G2HzL31910G2HzL9 L-FR1

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = GlnArg

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Xaa Ser Leu Ser Ala Ser Xaa Gly 
1               5                   10                  15      


Asp Xaa Val Thr Ile Thr Cys 
            20              


<210>  56
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR2; 1910G2HzL21910G2HzL31910G2HzL9 L-FR2

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LysArg

<400>  56

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Xaa Gln Leu Ile Arg 
1               5                   10                  15  


<210>  57
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR3; 1910G2HzL2 L-FR3; 1910G2HzL3 L-FR3; 1910G2HzL9 L-FR3

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = SerThr

<400>  57

Gly Xaa Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Xaa Xaa 
1               5                   10                  15      


Phe Xaa Ile Ser Xaa Xaa Xaa Xaa Glu Asp Ile Ala Xaa Tyr Tyr Cys 
            20                  25                  30          


<210>  58
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 L-FR4; 1910G2HzL21910G2HzL31910G2HzL9 L-FR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleLeu

<400>  58

Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Lys 
1               5                   10  


<210>  59
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50G2-3 VL; 1910G2HzL2 VL; 1910G2HzL3 VL; 1910G2HzL9 VL

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = GlnArg

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = IleLeu

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Xaa Ser Leu Ser Ala Ser Xaa Gly 
1               5                   10                  15      


Asp Xaa Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Xaa Gln Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Val Ser Gly Xaa Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Xaa Xaa Phe Xaa Ile Ser Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Glu Asp Ile Ala Xaa Tyr Tyr Cys Leu Gln Tyr Asp Asn Val Pro Asn 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Lys 
            100                 105         


<210>  60
<211>  95
<212>  PRT
<213>  ࣨHomo sapiens

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro 
                85                  90                  95  


<210>  61
<211>  12
<212>  PRT
<213>  ࣨHomo sapiens

<400>  61

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  62
<211>  98
<212>  PRT
<213>  ࣨHomo sapiens

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  63
<211>  15
<212>  PRT
<213>  ࣨHomo sapiens

<400>  63

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  
