б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  PD-1弰;

<130>  0134-PA-026

<160>  87

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 HCDR1

<400>  1

Gly Phe Thr Phe Ser Asn Tyr 
1               5           


<210>  2
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 HCDR2

<400>  2

Ser Gly Gly Gly Ser Tyr 
1               5       


<210>  3
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 HCDR3

<400>  3

Pro Tyr Tyr Gly Met Glu Tyr 
1               5           


<210>  4
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR1

<400>  4

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ala Cys Ala Ala Ser 
            20                  25  


<210>  5
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR2

<400>  5

Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
1               5                   10                  15      


Ala Thr Ile 
            


<210>  6
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR3

<400>  6

Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu 
            20                  25                  30          


Asp Thr Ala Leu Tyr Tyr Cys Val Ser 
        35                  40      


<210>  7
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR4

<400>  7

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 LCDR1

<400>  8

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 LCDR2

<400>  9

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 LCDR3

<400>  10

Gln Gln Tyr Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  11
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR1

<400>  11

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys 
            20              


<210>  12
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR2

<400>  12

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR3

<400>  13

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  14
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR4

<400>  14

Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
1               5                   10  


<210>  15
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 VH

<400>  15

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Ser Pro Tyr Tyr Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  16
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 VL

<400>  16

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210>  17
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3 H-FR1

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  18
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3 H-FR2

<400>  18

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Thr Ile 
            


<210>  19
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3 H-FR3

<400>  19

Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Val Ser 
        35                  40      


<210>  20
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3 H-FR4

<400>  20

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4 L-FR1

<400>  21

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  22
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4 L-FR2

<400>  22

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  23
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4 L-FR3

<400>  23

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  24
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4 L-FR4

<400>  24

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  25
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3 VH

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Pro Tyr Tyr Gly Met Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  26
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4 VL

<400>  26

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 HCDR1

<400>  27

Asp Tyr Glu Met His 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 HCDR2

<400>  28

Gly Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 HCDR3

<400>  29

Glu Gly Phe Asp Val Gly Trp Tyr Phe Asp Val 
1               5                   10      


<210>  30
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR1

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Phe Thr Phe Ile 
            20                  25                  30  


<210>  31
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR2

<400>  31

Trp Val Arg Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  32
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR3

<400>  32

Lys Ala Thr Leu Ile Ala Asp Ile Ser Thr Asn Thr Ala Ser Met Glu 
1               5                   10                  15      


Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  33
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR4

<400>  33

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  34
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 LCDR1

<400>  34

Arg Ser Ser Gln Ser Ile Val His Ser Asp Gly Asp Thr Phe Leu Glu 
1               5                   10                  15      


<210>  35
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 LCDR2

<400>  35

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 LCDR3

<400>  36

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  37
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR1

<400>  37

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  38
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR2

<400>  38

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  39
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR3

<400>  39

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Gly Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  40
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR4

<400>  40

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  41
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 VH

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Phe Thr Phe Ile Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ile Ala Asp Ile Ser Thr Asn Thr Ala Ser 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Val Gly Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 VL

<400>  42

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asp Thr Phe Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Gly Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4 H-FR1

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ile 
            20                  25                  30  


<210>  44
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4 H-FR2

<400>  44

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  45
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4 H-FR3

<400>  45

Arg Ala Thr Leu Thr Ala Asp Ile Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4 H-FR4

<400>  46

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  47
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3 L-FR1

<400>  47

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  48
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3 L-FR2

<400>  48

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  49
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3 L-FR3

<400>  49

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  50
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3 L-FR4

<400>  50

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  51
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4 VH

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ile Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Ile Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Val Gly Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  52
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3 VL

<400>  52

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asp Thr Phe Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  53
<211>  95
<212>  PRT
<213>  ࣨHomo sapiens

<400>  53

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro 
                85                  90                  95  


<210>  54
<211>  12
<212>  PRT
<213>  ࣨHomo sapiens

<400>  54

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  55
<211>  98
<212>  PRT
<213>  ࣨHomo sapiens

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  56
<211>  16
<212>  PRT
<213>  ࣨHomo sapiens

<400>  56

Asn Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15      


<210>  57
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR1; 1910D2HzH3 H-FR1

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AlaSer

<400>  57

Glu Val Xaa Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Xaa Cys Ala Ala Ser 
            20                  25  


<210>  58
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR1; 1910h3hzH4 H-FR1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LysVal

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = LeuSer

<400>  58

Gln Val Gln Leu Xaa Gln Ser Gly Ala Glu Xaa Xaa Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Xaa Gly Phe Thr Phe Ile 
            20                  25                  30  


<210>  59
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR2; 1910D2HzH3 H-FR2

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AlaSer

<400>  59

Asp Met Ser Trp Val Arg Gln Xaa Pro Xaa Lys Xaa Leu Glu Trp Val 
1               5                   10                  15      


Xaa Thr Ile 
            


<210>  60
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR2; 1910h3hzH4 H-FR2

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = GlyVal

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = HisGln

<400>  60

Trp Val Arg Gln Xaa Pro Xaa Xaa Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  61
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR3; 1910D2HzH3 H-FR3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = LeuVal

<400>  61

Thr Tyr Tyr Xaa Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Xaa Leu Tyr Leu Gln Met Xaa Ser Leu Arg Xaa Glu 
            20                  25                  30          


Asp Thr Ala Xaa Tyr Tyr Cys Val Ser 
        35                  40      


<210>  62
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR3; 1910h3hzH4 H-FR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = SerThr

<400>  62

Xaa Ala Thr Leu Xaa Ala Asp Ile Ser Xaa Xaa Thr Ala Xaa Met Glu 
1               5                   10                  15      


Xaa Ser Xaa Leu Xaa Ser Xaa Asp Xaa Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  63
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 H-FR4; 1910D2HzH3 H-FR4

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuSer

<400>  63

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 H-FR4; 1910h3hzH4 H-FR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaGln

<400>  64

Trp Gly Xaa Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  65
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 VH; 1910D2HzH3 VH

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa = LeuSer

<400>  65

Glu Val Xaa Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Xaa Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Xaa Pro Xaa Lys Xaa Leu Glu Trp Val 
        35                  40                  45              


Xaa Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Xaa Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Xaa Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Xaa Ser Leu Arg Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Val Ser Pro Tyr Tyr Gly Met Glu Tyr Trp Gly Gln Gly Thr Xaa Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  66
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 VH; 1910h3hzH4 VH

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = LysVal

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = LeuSer

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = GlyVal

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = HisGln

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa = AlaGln

<400>  66

Gln Val Gln Leu Xaa Gln Ser Gly Ala Glu Xaa Xaa Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Xaa Gly Phe Thr Phe Ile Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Xaa Pro Xaa Xaa Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Ala Thr Leu Xaa Ala Asp Ile Ser Xaa Xaa Thr Ala Xaa 
65                  70                  75                  80  


Met Glu Xaa Ser Xaa Leu Xaa Ser Xaa Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Val Gly Trp Tyr Phe Asp Val Trp Gly Xaa 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 VL; 1910D2HzL4 VL

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = HisPro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = LysSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = AspThr

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = IleVal

<400>  67

Asp Ile Xaa Xaa Thr Gln Ser Xaa Xaa Phe Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Xaa Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Thr Leu Thr Ile Ser Xaa Xaa Gln Xaa 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Xaa Glu Xaa Lys 
            100                 105         


<210>  68
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 VL; 1910h3hzL3 VL

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ProGln

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = GlyGln

<400>  68

Asp Val Xaa Met Thr Gln Xaa Pro Leu Ser Leu Pro Val Xaa Leu Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asp Thr Phe Leu Glu Trp Tyr Xaa Gln Xaa Pro Gly Gln Ser 
        35                  40                  45              


Pro Xaa Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Xaa Glu Asp Xaa Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  69
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR1; 1910D2HzL4 L-FR1

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = HisPro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = LysSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<400>  69

Asp Ile Xaa Xaa Thr Gln Ser Xaa Xaa Phe Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys 
            20              


<210>  70
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR1; 1910h3hzL3 L-FR1

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ProGln

<400>  70

Asp Val Xaa Met Thr Gln Xaa Pro Leu Ser Leu Pro Val Xaa Leu Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys 
            20              


<210>  71
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR2; 1910D2HzL4 L-FR2

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<400>  71

Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR2; 1910h3hzL3 L-FR2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LysArg

<400>  72

Trp Tyr Xaa Gln Xaa Pro Gly Gln Ser Pro Xaa Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  73
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR3; 1910D2HzL4 L-FR3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = AspThr

<400>  73

Gly Val Pro Xaa Arg Phe Xaa Gly Ser Gly Ser Gly Thr Xaa Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Xaa Xaa Gln Xaa Glu Asp Xaa Ala Xaa Tyr Phe Cys 
            20                  25                  30          


<210>  74
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR3; 1910h3hzL3 L-FR3

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = LeuVal

<400>  74

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Xaa Glu Asp Xaa Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  75
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  41D2-2C3D7 L-FR4; 1910D2HzL4 L-FR4

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleVal

<400>  75

Phe Gly Gly Gly Thr Lys Xaa Glu Xaa Lys 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  46H3A8 L-FR4; 1910h3hzL3 L-FR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlyGln

<400>  76

Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  77
<211>  327
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4㶨

<400>  77

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  78
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3㶨

<400>  78

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  79
<211>  447
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzH4

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ile Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile His Pro Gly Ser Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Ile Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Val Gly Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  80
<211>  219
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910h3hzL3

<400>  80

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asp Thr Phe Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  81
<211>  327
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3㶨

<400>  81

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  82
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4㶨

<400>  82

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  83
<211>  443
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzH3

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Pro Tyr Tyr Gly Met Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  84
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1910D2HzL4

<400>  84

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 

<210>  85
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2005Am08 HCDR2

<400>  85

Ser Gly Gly Gly Arg Tyr 
1               5       


<210>  86
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2005Am08 VH

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Pro Tyr Tyr Gly Met Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  87
<211>  446
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2005Am08 

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Pro Tyr Tyr Gly Met Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

