                         SEQUENCE LISTING

<110>  Ϻ＼޹˾
 
<120>  Ras G13DͻλļʶRas G13DͻTϸ

<130>  IEC220052PCT

<150>  PCT/CN2021/076432
<151>  2021-02-10

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  2012
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ras G13D-mRNA

<400>  1
cttgttcttt ttgcagaagc tcagaataaa cgctcaactt tgggccacca tgccccggca       60

gctcagcgcg gcggccgcgc tcttcgcgtc cctggccgta attttgcacg atggcagtca      120

aatgagagca aaagcatttc cagaaaccag agattattct caacctactg cagcagcaac      180

agtacaggac ataaaaaaac ctgtccagca accagctaag caagcacctc accaaacttt      240

agcagcaaga ttcatggatg gtcatatcac ctttcaaaca gcggccacag taaaaattcc      300

aacaactacc ccagcgacta caaaaaacac tgcaaccacc agcccaatta cctacaccct      360

ggtcacaacc caggccacac ccaacaactc acacacagct cctccagtta ctgaagttac      420

agtcggccct agcttagccc cttattcact gccacccacc atcaccccac cagctcatac      480

aactggaacc agttcatcaa ccgtcagcca cacaactggg aacaccactc aacccagtaa      540

ccagaccacc cttccagcaa ctttatcgat agcactgcac aaaagcacaa ccggtcagaa      600

gcctgttcaa cccacccatg ccccaggaac aacggcagct gcccacaata ccacccgcac      660

agctgcacct gcctccacgg ttcctgggcc cacccttgca cctcagccat cgtcagtcaa      720

gactggaatt tatcaggttc taaacggaag cagactctgt ataaaagcag agatggggat      780

acagctgatt gttcaagaca aggagtcggt tttttcacct cggagatact tcaacatcga      840

ccccaacgca acgcaagcct ctgggaactg tggcacccga aaatccaacc ttctgttgaa      900

ttttcagggc ggatttgtga atctcacatt taccaaggat gaagaatcat attatatcag      960

tgaagtggga gcctatttga ccgtctcaga tccagagaca atttaccaag gaatcaaaca     1020

tgcggtggtg atgttccaga cagcagtcgg gcattccttc aagtgcgtga gtgaacagag     1080

cctccagttg tcagcccacc tgcaggtgaa aacaaccgat gtccaacttc aagcctttga     1140

ttttgaagat gaccactttg gaaatgtgga tgagtgctcg tctgactaca caactgaata     1200

taaacttgtg gtagttggag ctggcgatgt aggcaagagt gccttgacga tacagctaat     1260

tcagaatcat tttgtggacg aatatgatcc aacaatagag gattcctaca ggaagcaagt     1320

agtaattgat ggagaaacct gtctcttgga tattctcgac acagcaggtc aagaggagta     1380

cagtgcaatg agggaccagt acatgaggac tggggagggc tttctttgtg tatttgccat     1440

aaataatact aaatcatttg aagatattca ccattataga gaacaaatta aaagagttaa     1500

ggactctgaa gatgtaccta tggtcctagt aggaaataaa tgtgatttgc cttctagaac     1560

agtagacaca aaacaggctc aggacttagc aagaagttat ggaattcctt ttattgaaac     1620

atcagcaaag acaagacagg gtgttgatga tgccttctat acattagttc gagaaattcg     1680

aaaacataaa gaaaagatga gcaaagatgg taaaaagaag aaaaagaagt caaagacaaa     1740

gtgtgtaatt atgattgtgc ttcctgtgat tggggccatc gtggttggtc tctgccttat     1800

gggtatgggt gtctataaaa tccgcctaag gtgtcaatca tctggatacc agagaatcta     1860

atcctctaga ggatctggtt accactaaac cagcctcaag aacacccgaa tggagtctct     1920

aagctacata ataccaactt acacttacaa aatgttgtcc cccaaaatgt agccattcgt     1980

atctgctcct aataaaaaga aagtttcttc ac                                   2012


<210>  2
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR V

<400>  2
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgagagagag gaccggcact      360

gccagtaaac tcacctttgg gactggaaca agacttcagg tcacgctc                   408


<210>  3
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Vº

<400>  3
atgggaatca ggctcctctg tcgtgtggcc ttttgtttcc tggctgtagg cctcgtagat       60

gtgaaagtaa cccagagctc gagatatcta gtcaaaagga cgggagagaa agtttttctg      120

gaatgtgtcc aggatatgga ccatgaaaat atgttctggt atcgacaaga cccaggtctg      180

gggctacggc tgatctattt ctcatatgat gttaaaatga aagaaaaagg agatattcct      240

gaggggtaca gtgtctctag agagaagaag gagcgcttct ccctgattct ggagtccgcc      300

agcaccaacc agacatctat gtacctctgt gccagcagcc agacggtgcc gccccagcat      360

tttggtgatg ggactcgact ctccatccta                                       390


<210>  4
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR V

<400>  4

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Arg Thr Gly Thr Ala Ser Lys Leu Thr Phe Gly Thr 
        115                 120                 125             


Gly Thr Arg Leu Gln Val Thr Leu 
    130                 135     


<210>  5
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR V°

<400>  5

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Thr Val Pro Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Leu 
    130 


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR1

<400>  6

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR2

<400>  7

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR3

<400>  8

Ala Met Arg Glu Arg Thr Gly Thr Ala Ser Lys Leu Thr 
1               5                   10              


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR1°

<400>  9

Met Asp His Glu Asn 
1               5   


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR2°

<400>  10

Ser Tyr Asp Val Lys Met 
1               5       


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR3°

<400>  11

Ala Ser Ser Gln Thr Val Pro Pro Gln His 
1               5                   10  


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RAS WT23mer

<400>  12

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln Leu Ile 
            20              


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D 23mer

<400>  13

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln Leu Ile 
            20              


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  λĺİ

<400>  14

Val Val Val Gly Ala Gly Asp Val Gly Lys Ser 
1               5                   10      


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT1

<400>  15

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr 
1               5                   10                  15      


Ile Gln Leu 
            


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT2

<400>  16

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr 
1               5                   10                  15      


Ile Gln 
        


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT3

<400>  17

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr 
1               5                   10                  15      


Ile 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT4

<400>  18

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


Thr 
    


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT5

<400>  19

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6

<400>  20

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT7

<400>  21

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT8

<400>  22

Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT9

<400>  23

Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10              


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT10

<400>  24

Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT11

<400>  25

Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10      


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT12

<400>  26

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala 
1               5                   10                  


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT13

<400>  27

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser 
1               5                   10              


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT14

<400>  28

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys 
1               5                   10          


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT15

<400>  29

Lys Leu Val Val Val Gly Ala Gly Asp Val Gly 
1               5                   10      


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A1

<400>  30

Ala Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A2

<400>  31

Tyr Ala Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A3

<400>  32

Tyr Lys Ala Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A4

<400>  33

Tyr Lys Leu Ala Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A5

<400>  34

Tyr Lys Leu Val Ala Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A6

<400>  35

Tyr Lys Leu Val Val Ala Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A7

<400>  36

Tyr Lys Leu Val Val Val Ala Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-G8

<400>  37

Tyr Lys Leu Val Val Val Gly Gly Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A9

<400>  38

Tyr Lys Leu Val Val Val Gly Ala Ala Asp Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A11

<400>  39

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Ala Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A12

<400>  40

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Ala Lys Ser Ala Leu 
1               5                   10                  15      


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A13

<400>  41

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Ala Ser Ala Leu 
1               5                   10                  15      


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A14

<400>  42

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ala Ala Leu 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-G15

<400>  43

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Gly Leu 
1               5                   10                  15      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G13D-RT6-A16

<400>  44

Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys Ser Ala Ala 
1               5                   10                  15      


<210>  45
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR㶨

<400>  45

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  46
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR㶨

<400>  46
gacatccaga acccagaacc tgctgtgtac cagttaaaag atcctcggtc tcaggacagc       60

accctctgcc tgttcaccga ctttgactcc caaatcaatg tgccgaaaac catggaatct      120

ggaacgttca tcactgacaa aactgtgctg gacatgaaag ctatggattc caagagcaat      180

ggggccattg cctggagcaa ccagacaagc ttcacctgcc aagatatctt caaagagacc      240

aacgccacct accccagttc agacgttccc tgtgatgcca cgttgactga gaaaagcttt      300

gaaacagata tgaacctaaa ctttcaaaac ctgtcagtta tgggactccg aatcctcctg      360

ctgaaagtag ccggatttaa cctgctcatg acgctgaggc tgtggtccag t               411


<210>  47
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRº㶨

<400>  47

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  48
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCRº㶨

<400>  48
gaggacctgc gcaacgtcac cccaccaaag gtcagtttgt ttgagccatc aaaggcggag       60

atcgccaaca aacagaaagc tacgctcgtg tgtttggctc ggggcttctt cccagaccac      120

gtagaacttt cctggtgggt caatggaaag gaggttcatt ccggagtgtc cactgatccc      180

caagcgtaca aggaatccaa ctatagctac tgtctctcat ctcggctccg ggtgagtgcg      240

acattctggc ataatcctcg gaaccacttt cgatgccaag tgcagtttca tgggttgagc      300

gaggaagaca agtggcccga gggcagtcct aaaccagtca ctcaaaacat aagcgccgag      360

gcatggggta gagccgattg tgggattact agcgcttcat accaacaagg ggtattgagc      420

gctacaattc tttacgaaat tctcctcggc aaggcgacgc tctacgccgt actggtgtct      480

actctcgtgg ttatggcaat ggtgaaacgg aaaaacagc                             519


<210>  49
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B8.2.4/TRAV+mCa

<400>  49
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgagagagag gaccggcact      360

gccagtaaac tcacctttgg gactggaaca agacttcagg tcacgctcga catccagaac      420

ccagaacctg ctgtgtacca gttaaaagat cctcggtctc aggacagcac cctctgcctg      480

ttcaccgact ttgactccca aatcaatgtg ccgaaaacca tggaatctgg aacgttcatc      540

actgacaaaa ctgtgctgga catgaaagct atggattcca agagcaatgg ggccattgcc      600

tggagcaacc agacaagctt cacctgccaa gatatcttca aagagaccaa cgccacctac      660

cccagttcag acgttccctg tgatgccacg ttgactgaga aaagctttga aacagatatg      720

aacctaaact ttcaaaacct gtcagttatg ggactccgaa tcctcctgct gaaagtagcc      780

ggatttaacc tgctcatgac gctgaggctg tggtccagt                             819


<210>  50
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B8.2.4/TRBV+mCb

<400>  50
atgggaatca ggctcctctg tcgtgtggcc ttttgtttcc tggctgtagg cctcgtagat       60

gtgaaagtaa cccagagctc gagatatcta gtcaaaagga cgggagagaa agtttttctg      120

gaatgtgtcc aggatatgga ccatgaaaat atgttctggt atcgacaaga cccaggtctg      180

gggctacggc tgatctattt ctcatatgat gttaaaatga aagaaaaagg agatattcct      240

gaggggtaca gtgtctctag agagaagaag gagcgcttct ccctgattct ggagtccgcc      300

agcaccaacc agacatctat gtacctctgt gccagcagcc agacggtgcc gccccagcat      360

tttggtgatg ggactcgact ctccatccta gaggacctgc gcaacgtcac cccaccaaag      420

gtcagtttgt ttgagccatc aaaggcggag atcgccaaca aacagaaagc tacgctcgtg      480

tgtttggctc ggggcttctt cccagaccac gtagaacttt cctggtgggt caatggaaag      540

gaggttcatt ccggagtgtc cactgatccc caagcgtaca aggaatccaa ctatagctac      600

tgtctctcat ctcggctccg ggtgagtgcg acattctggc ataatcctcg gaaccacttt      660

cgatgccaag tgcagtttca tgggttgagc gaggaagaca agtggcccga gggcagtcct      720

aaaccagtca ctcaaaacat aagcgccgag gcatggggta gagccgattg tgggattact      780

agcgcttcat accaacaagg ggtattgagc gctacaattc tttacgaaat tctcctcggc      840

aaggcgacgc tctacgccgt actggtgtct actctcgtgg ttatggcaat ggtgaaacgg      900

aaaaacagc                                                              909


<210>  51
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RAS G13Dͻ就

<400>  51

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT-RT6

<400>  52

Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys Ser Ala Leu 
1               5                   10                  15      


<210>  53
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  53
gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggcccc          57


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-A

<400>  54

Ala Ser Ser Ala Thr Val Pro Pro Gln His 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-C

<400>  55

Ala Ser Ser Cys Thr Val Pro Pro Gln His 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-D

<400>  56

Ala Ser Ser Asp Thr Val Pro Pro Gln His 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-E

<400>  57

Ala Ser Ser Glu Thr Val Pro Pro Gln His 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-G

<400>  58

Ala Ser Ser Gly Thr Val Pro Pro Gln His 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-H

<400>  59

Ala Ser Ser His Thr Val Pro Pro Gln His 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-I

<400>  60

Ala Ser Ser Ile Thr Val Pro Pro Gln His 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-L

<400>  61

Ala Ser Ser Leu Thr Val Pro Pro Gln His 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-M

<400>  62

Ala Ser Ser Met Thr Val Pro Pro Gln His 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-N

<400>  63

Ala Ser Ser Asn Thr Val Pro Pro Gln His 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-S

<400>  64

Ala Ser Ser Ser Thr Val Pro Pro Gln His 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-T

<400>  65

Ala Ser Ser Thr Thr Val Pro Pro Gln His 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-V

<400>  66

Ala Ser Ser Val Thr Val Pro Pro Gln His 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-W

<400>  67

Ala Ser Ser Trp Thr Val Pro Pro Gln His 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR395Q-Y

<400>  68

Ala Ser Ser Tyr Thr Val Pro Pro Gln His 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-A

<400>  69

Ala Ser Ser Gln Ala Val Pro Pro Gln His 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-C

<400>  70

Ala Ser Ser Gln Cys Val Pro Pro Gln His 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-H

<400>  71

Ala Ser Ser Gln His Val Pro Pro Gln His 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-K

<400>  72

Ala Ser Ser Gln Lys Val Pro Pro Gln His 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-N

<400>  73

Ala Ser Ser Gln Asn Val Pro Pro Gln His 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-S

<400>  74

Ala Ser Ser Gln Ser Val Pro Pro Gln His 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-V

<400>  75

Ala Ser Ser Gln Val Val Pro Pro Gln His 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR396T-W

<400>  76

Ala Ser Ser Gln Trp Val Pro Pro Gln His 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR397V-I

<400>  77

Ala Ser Ser Gln Thr Ile Pro Pro Gln His 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR397V-S

<400>  78

Ala Ser Ser Gln Thr Ser Pro Pro Gln His 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR397V-T

<400>  79

Ala Ser Ser Gln Thr Thr Pro Pro Gln His 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-C

<400>  80

Ala Ser Ser Gln Thr Val Cys Pro Gln His 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-D

<400>  81

Ala Ser Ser Gln Thr Val Asp Pro Gln His 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-E

<400>  82

Ala Ser Ser Gln Thr Val Glu Pro Gln His 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-F

<400>  83

Ala Ser Ser Gln Thr Val Phe Pro Gln His 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-G

<400>  84

Ala Ser Ser Gln Thr Val Gly Pro Gln His 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-H

<400>  85

Ala Ser Ser Gln Thr Val His Pro Gln His 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-L

<400>  86

Ala Ser Ser Gln Thr Val Leu Pro Gln His 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-M

<400>  87

Ala Ser Ser Gln Thr Val Met Pro Gln His 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-R

<400>  88

Ala Ser Ser Gln Thr Val Arg Pro Gln His 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-S

<400>  89

Ala Ser Ser Gln Thr Val Ser Pro Gln His 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-V

<400>  90

Ala Ser Ser Gln Thr Val Val Pro Gln His 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR398P-W

<400>  91

Ala Ser Ser Gln Thr Val Trp Pro Gln His 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR CDR3ͨʽ


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  XaaѡGlnAlaCysAspGluGlyHisIleLeuMetAsnSerThrValTrpTyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  XaaѡThrAlaCysHisLysAsnSerValTrp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  XaaѡValIleSerThr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  XaaѡProCysAspGluPheGlyHisLeuMetArgSerValTrp

<400>  92

Ala Ser Ser Xaa Xaa Xaa Xaa Pro Gln His 
1               5                   10  


<210>  93
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  93

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp 
        35                  40                  45      


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  94

Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  95
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  95

Ala Thr Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser 
1               5                   10                  15      


Ala Asn Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr 
            20                  25                  30          


Phe Cys 
        


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  96

Phe Gly Thr Gly Thr Arg Leu Gln Val Thr Leu 
1               5                   10      


<210>  97
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1°

<400>  97

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp 
        35                  40                  45  


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2°

<400>  98

Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr 
1               5                   10                  15      


Phe 
    


<210>  99
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3°

<400>  99

Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr Ser Val Ser Arg Glu Lys 
1               5                   10                  15      


Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser Ala Ser Thr Asn Gln Thr 
            20                  25                  30          


Ser Met Tyr Leu Cys 
        35          


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4°

<400>  100

Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
1               5                   10  


