
                                SEQUENCE LISTING

<110> Marson, Alexander
      Mamedov, Murad
      The J. David Gladstone Institutes, a testamentary trust established
          under the Will of J. David Gladstone
      The Regents of the University of California

<120> Regulation of Butyrophilin subfamily 3 member A1 (BTN3A1, CD277)
  

<130> 3730.182WO1

<150> US 63/147,050       
<151> 2021-02-08  

<160> 220

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 513
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly
145                 150                 155                 160
Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln
                165                 170                 175
Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala
            180                 185                 190
Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val
        195                 200                 205
Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser
    210                 215                 220
Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro
225                 230                 235                 240
Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu
                245                 250                 255
Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln
            260                 265                 270
Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln
        275                 280                 285
Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr
    290                 295                 300
Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala
305                 310                 315                 320
Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu
                325                 330                 335
Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile
            340                 345                 350
Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro
        355                 360                 365
Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val
    370                 375                 380
Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu
385                 390                 395                 400
Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val
                405                 410                 415
Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr
            420                 425                 430
Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg
        435                 440                 445
Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu
    450                 455                 460
Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser
465                 470                 475                 480
His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro
                485                 490                 495
Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro
            500                 505                 510
Ala


<210> 2
<211> 352
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly
145                 150                 155                 160
Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln
                165                 170                 175
Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala
            180                 185                 190
Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val
        195                 200                 205
Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser
    210                 215                 220
Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro
225                 230                 235                 240
Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu
                245                 250                 255
Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln
            260                 265                 270
Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln
        275                 280                 285
Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr
    290                 295                 300
Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala
305                 310                 315                 320
Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu
                325                 330                 335
Phe Lys Pro Gly Glu Glu Met Leu Gln Met Arg Leu His Phe Val Lys
            340                 345                 350

<210> 3
<211> 461
<212> PRT
<213> Homo sapiens

<400> 3
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met Arg Gly
145                 150                 155                 160
Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly
                165                 170                 175
Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser
            180                 185                 190
Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Val Leu Leu
        195                 200                 205
Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln Gln Gln Glu Glu
    210                 215                 220
Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln Glu Leu Arg Glu
225                 230                 235                 240
Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr Arg Val Lys Leu
                245                 250                 255
Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu
            260                 265                 270
Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala
        275                 280                 285
Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile Leu Leu Val Ser
    290                 295                 300
Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro
305                 310                 315                 320
Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu
                325                 330                 335
Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg
            340                 345                 350
Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly
        355                 360                 365
Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr Met Gly Leu Thr
    370                 375                 380
Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg Thr Asn Leu Lys
385                 390                 395                 400
Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Thr
                405                 410                 415
Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Thr
            420                 425                 430
Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile
        435                 440                 445
Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro Ala
    450                 455                 460

<210> 4
<211> 378
<212> PRT
<213> Homo sapiens

<400> 4
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly
145                 150                 155                 160
Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln
                165                 170                 175
Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala
            180                 185                 190
Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val
        195                 200                 205
Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser
    210                 215                 220
Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro
225                 230                 235                 240
Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu
                245                 250                 255
Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln
            260                 265                 270
Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln
        275                 280                 285
Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr
    290                 295                 300
Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala
305                 310                 315                 320
Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu
                325                 330                 335
Phe Lys Pro Gly Pro Pro Ile Gly Gln Thr Gln Gln Gln Thr Arg Gly
            340                 345                 350
Gln Gly Ser Pro Val Ala Leu Ser Gln Glu Ser Ala Gln Arg Thr Asp
        355                 360                 365
Ser Trp Gly Pro Glu Glu Gly Gly Glu Ser
    370                 375

<210> 5
<211> 506
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly
145                 150                 155                 160
Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln
                165                 170                 175
Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala
            180                 185                 190
Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val
        195                 200                 205
Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser
    210                 215                 220
Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro
225                 230                 235                 240
Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu
                245                 250                 255
Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln
            260                 265                 270
Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln
        275                 280                 285
Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr
    290                 295                 300
Arg Gly Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu Arg His Ser
305                 310                 315                 320
Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala Asp Val Ile
                325                 330                 335
Leu Asp Pro Lys Thr Ala Asn Pro Ile Leu Leu Val Ser Glu Asp Gln
            340                 345                 350
Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro Asp Asn Pro
        355                 360                 365
Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu Ser Phe Ile
    370                 375                 380
Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Lys Glu Trp
385                 390                 395                 400
His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly Trp Val Lys
                405                 410                 415
Met Thr Pro Glu Asn Gly Phe Trp Thr Met Gly Leu Thr Asp Gly Asn
            420                 425                 430
Lys Tyr Arg Thr Leu Thr Glu Pro Arg Thr Asn Leu Lys Leu Pro Lys
        435                 440                 445
Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Thr Gly Asp Ile
    450                 455                 460
Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Thr Phe Leu Asp
465                 470                 475                 480
Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile Leu Thr Leu
                485                 490                 495
Glu Pro Thr Ala Leu Thr Ile Cys Pro Ala
            500                 505

<210> 6
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly
145                 150                 155                 160
Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln
                165                 170                 175
Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala
            180                 185                 190
Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val
        195                 200                 205
Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser
    210                 215                 220
Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro
225                 230                 235                 240
Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu
                245                 250                 255
Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln
            260                 265                 270
Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln
        275                 280                 285
Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr
    290                 295                 300
Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala
305                 310                 315                 320
Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu
                325                 330                 335
Phe Lys Pro Gly Glu Glu Met Leu Gln Met Arg Leu His Phe Val Lys
            340                 345                 350

<210> 7
<211> 419
<212> PRT
<213> Homo sapiens

<400> 7
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val
 1               5                  10                  15
Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly
145                 150                 155                 160
Thr Leu Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu
                165                 170                 175
Trp Gln Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg
            180                 185                 190
Glu Gln Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln
        195                 200                 205
Ser Thr Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln
    210                 215                 220
Tyr Ala Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys
225                 230                 235                 240
Ala Leu Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn
                245                 250                 255
Pro Ile Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys
            260                 265                 270
Glu Pro Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr
        275                 280                 285
Cys Val Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu
    290                 295                 300
Val Glu Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys
305                 310                 315                 320
Asn Val Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe
                325                 330                 335
Trp Thr Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu
            340                 345                 350
Pro Arg Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val
        355                 360                 365
Phe Leu Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp
    370                 375                 380
Gly Ser His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu
385                 390                 395                 400
Tyr Pro Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile
                405                 410                 415
Cys Pro Ala


<210> 8
<211> 440
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg
 1               5                  10                  15
Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu
            20                  25                  30
Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys Asp Val
        35                  40                  45
Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile His Glu
    50                  55                  60
Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Thr Ile Thr
65                  70                  75                  80
Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val
                85                  90                  95
Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp
            100                 105                 110
Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Thr
        115                 120                 125
Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Thr
    130                 135                 140
Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser Val Glu
145                 150                 155                 160
Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr
                165                 170                 175
Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg
            180                 185                 190
Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser
        195                 200                 205
Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Thr Leu Gln
    210                 215                 220
Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu His Cys Gly Leu Asn
225                 230                 235                 240
Glu His Asn His His Leu Ile Asn Asp Phe Thr Val Lys Gln Met Arg
                245                 250                 255
Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly Gly Leu Val Asp Glu
            260                 265                 270
Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala
        275                 280                 285
Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu
    290                 295                 300
Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Ala Ala Trp Tyr Ser
305                 310                 315                 320
Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg
                325                 330                 335
Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn
            340                 345                 350
Lys Asp His Leu Thr Ala Ala Thr His Trp Ala Ser Met Asp Pro Ala
        355                 360                 365
Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly
    370                 375                 380
Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala Ala Val Glu Gly Ile
385                 390                 395                 400
Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His
                405                 410                 415
Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val Lys Pro Glu Ala Asp
            420                 425                 430
Arg Asp His Ala Ser Asp Gln Leu
        435                 440

<210> 9
<211> 193
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Asp Asp Asp Ser Arg Ala Ser Thr Ser Ser Ser Ser Ser Ser
 1               5                  10                  15
Ser Ser Asn Gln Gln Thr Glu Lys Glu Thr Asn Thr Pro Lys Lys Lys
            20                  25                  30
Glu Ser Lys Val Ser Met Ser Lys Asn Ser Lys Leu Leu Ser Thr Ser
        35                  40                  45
Ala Lys Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro
    50                  55                  60
Pro Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg
65                  70                  75                  80
Ser Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe
                85                  90                  95
Phe Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys
            100                 105                 110
Val Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly
        115                 120                 125
Val Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr
    130                 135                 140
Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn
145                 150                 155                 160
Pro Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn
                165                 170                 175
Arg Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala
            180                 185                 190
Thr


<210> 10
<211> 406
<212> PRT
<213> Homo sapiens

<400> 10
Met Thr Thr Pro Ala Asn Ala Gln Asn Ala Ser Lys Thr Trp Glu Leu
 1               5                  10                  15
Ser Leu Tyr Glu Leu His Arg Thr Pro Gln Glu Ala Ile Met Asp Gly
            20                  25                  30
Thr Glu Ile Ala Val Ser Pro Arg Ser Leu His Ser Glu Leu Met Cys
        35                  40                  45
Pro Ile Cys Leu Asp Met Leu Lys Asn Thr Met Thr Thr Lys Glu Cys
    50                  55                  60
Leu His Arg Phe Cys Ser Asp Cys Ile Val Thr Ala Leu Arg Ser Gly
65                  70                  75                  80
Asn Lys Glu Cys Pro Thr Cys Arg Lys Lys Leu Val Ser Lys Arg Ser
                85                  90                  95
Leu Arg Pro Asp Pro Asn Phe Asp Ala Leu Ile Ser Lys Ile Tyr Pro
            100                 105                 110
Ser Arg Glu Glu Tyr Glu Ala His Gln Asp Arg Val Leu Ile Arg Leu
        115                 120                 125
Ser Arg Leu His Asn Gln Gln Ala Leu Ser Ser Ser Ile Glu Glu Gly
    130                 135                 140
Leu Arg Met Gln Ala Met His Arg Ala Gln Arg Val Arg Arg Pro Ile
145                 150                 155                 160
Pro Gly Ser Asp Gln Thr Thr Thr Met Ser Gly Gly Glu Gly Glu Pro
                165                 170                 175
Gly Glu Gly Glu Gly Asp Gly Glu Asp Val Ser Ser Asp Ser Ala Pro
            180                 185                 190
Asp Ser Ala Pro Gly Pro Ala Pro Lys Arg Pro Arg Gly Gly Gly Ala
        195                 200                 205
Gly Gly Ser Ser Val Gly Thr Gly Gly Gly Gly Thr Gly Gly Val Gly
    210                 215                 220
Gly Gly Ala Gly Ser Glu Asp Ser Gly Asp Arg Gly Gly Thr Leu Gly
225                 230                 235                 240
Gly Gly Thr Leu Gly Pro Pro Ser Pro Pro Gly Ala Pro Ser Pro Pro
                245                 250                 255
Glu Pro Gly Gly Glu Ile Glu Leu Val Phe Arg Pro His Pro Leu Leu
            260                 265                 270
Val Glu Lys Gly Glu Tyr Cys Gln Thr Arg Tyr Val Lys Thr Thr Gly
        275                 280                 285
Asn Ala Thr Val Asp His Leu Ser Lys Tyr Leu Ala Leu Arg Ile Ala
    290                 295                 300
Leu Glu Arg Arg Gln Gln Gln Glu Ala Gly Glu Pro Gly Gly Pro Gly
305                 310                 315                 320
Gly Gly Ala Ser Asp Thr Gly Gly Pro Asp Gly Cys Gly Gly Glu Gly
                325                 330                 335
Gly Gly Ala Gly Gly Gly Asp Gly Pro Glu Glu Pro Ala Leu Pro Ser
            340                 345                 350
Leu Glu Gly Val Ser Glu Lys Gln Tyr Thr Ile Tyr Ile Ala Pro Gly
        355                 360                 365
Gly Gly Ala Phe Thr Thr Leu Asn Gly Ser Leu Thr Leu Glu Leu Val
    370                 375                 380
Asn Glu Lys Phe Trp Lys Val Ser Arg Pro Leu Glu Leu Cys Tyr Ala
385                 390                 395                 400
Pro Thr Lys Asp Pro Lys
                405

<210> 11
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 11
Met Gln Ser Lys Val Thr Gly Asn Met Pro Thr Gln Ser Leu Leu Met
 1               5                  10                  15
Tyr Met Asp Gly Pro Glu Val Ile Gly Ser Ser Leu Gly Ser Pro Met
            20                  25                  30
Glu Met Glu Asp Ala Leu Ser Met Lys Gly Thr Ala Val Val Pro Phe
        35                  40                  45
Arg Ala Thr Gln Glu Lys Asn Val Ile Gln Ile Glu Gly Tyr Met Pro
    50                  55                  60
Leu Asp Cys Met Phe Cys Ser Gln Thr Phe Thr His Ser Glu Asp Leu
65                  70                  75                  80
Asn Lys His Val Leu Met Gln His Arg Pro Thr Leu Cys Glu Pro Ala
                85                  90                  95
Val Leu Arg Val Glu Ala Glu Tyr Leu Ser Pro Leu Asp Lys Ser Gln
            100                 105                 110
Val Arg Thr Glu Pro Pro Lys Glu Lys Asn Cys Lys Glu Asn Glu Phe
        115                 120                 125
Ser Cys Glu Val Cys Gly Gln Thr Phe Arg Val Ala Phe Asp Val Glu
    130                 135                 140
Ile His Met Arg Thr His Lys Asp Ser Phe Thr Tyr Gly Cys Asn Met
145                 150                 155                 160
Cys Gly Arg Arg Phe Lys Glu Pro Trp Phe Leu Lys Asn His Met Arg
                165                 170                 175
Thr His Asn Gly Lys Ser Gly Ala Arg Ser Lys Leu Gln Gln Gly Leu
            180                 185                 190
Glu Ser Ser Pro Ala Thr Ile Asn Glu Val Val Gln Val His Ala Ala
        195                 200                 205
Glu Ser Ile Ser Ser Pro Tyr Lys Ile Cys Met Val Cys Gly Phe Leu
    210                 215                 220
Phe Pro Asn Lys Glu Ser Leu Ile Glu His Arg Lys Val His Thr Lys
225                 230                 235                 240
Lys Thr Ala Phe Gly Thr Ser Ser Ala Gln Thr Asp Ser Pro Gln Gly
                245                 250                 255
Gly Met Pro Ser Ser Arg Glu Asp Phe Leu Gln Leu Phe Asn Leu Arg
            260                 265                 270
Pro Lys Ser His Pro Glu Thr Gly Lys Lys Pro Val Arg Cys Ile Pro
        275                 280                 285
Gln Leu Asp Pro Phe Thr Thr Phe Gln Ala Trp Gln Leu Ala Thr Lys
    290                 295                 300
Gly Lys Val Ala Ile Cys Gln Glu Val Lys Glu Ser Gly Gln Glu Gly
305                 310                 315                 320
Ser Thr Asp Asn Asp Asp Ser Ser Ser Glu Lys Glu Leu Gly Glu Thr
                325                 330                 335
Asn Lys Gly Ser Cys Ala Gly Leu Ser Gln Glu Lys Glu Lys Cys Lys
            340                 345                 350
His Ser His Gly Glu Ala Pro Ser Val Asp Ala Asp Pro Lys Leu Pro
        355                 360                 365
Ser Ser Lys Glu Lys Pro Thr His Cys Ser Glu Cys Gly Lys Ala Phe
    370                 375                 380
Arg Thr Tyr His Gln Leu Val Leu His Ser Arg Val His Lys Lys Asp
385                 390                 395                 400
Arg Arg Ala Gly Ala Glu Ser Pro Thr Met Ser Val Asp Gly Arg Gln
                405                 410                 415
Pro Gly Thr Cys Ser Pro Asp Leu Ala Ala Pro Leu Asp Glu Asn Gly
            420                 425                 430
Ala Val Asp Arg Gly Glu Gly Gly Ser Glu Asp Gly Ser Glu Asp Gly
        435                 440                 445
Leu Pro Glu Gly Ile His Leu Asp Lys Asn Asp Asp Gly Gly Lys Ile
    450                 455                 460
Lys His Leu Thr Ser Ser Arg Glu Cys Ser Tyr Cys Gly Lys Phe Phe
465                 470                 475                 480
Arg Ser Asn Tyr Tyr Leu Asn Ile His Leu Arg Thr His Thr Gly Glu
                485                 490                 495
Lys Pro Tyr Lys Cys Glu Phe Cys Glu Tyr Ala Ala Ala Gln Lys Thr
            500                 505                 510
Ser Leu Arg Tyr His Leu Glu Arg His His Lys Glu Lys Gln Thr Asp
        515                 520                 525
Val Ala Ala Glu Val Lys Asn Asp Gly Lys Asn Gln Asp Thr Glu Asp
    530                 535                 540
Ala Leu Leu Thr Ala Asp Ser Ala Gln Thr Lys Asn Leu Lys Arg Phe
545                 550                 555                 560
Phe Asp Gly Ala Lys Asp Val Thr Gly Ser Pro Pro Ala Lys Gln Leu
                565                 570                 575
Lys Glu Met Pro Ser Val Phe Gln Asn Val Leu Gly Ser Ala Val Leu
            580                 585                 590
Ser Pro Ala His Lys Asp Thr Gln Asp Phe His Lys Asn Ala Ala Asp
        595                 600                 605
Asp Ser Ala Asp Lys Val Asn Lys Asn Pro Thr Pro Ala Tyr Leu Asp
    610                 615                 620
Leu Leu Lys Lys Arg Ser Ala Val Glu Thr Gln Ala Asn Asn Leu Ile
625                 630                 635                 640
Cys Arg Thr Lys Ala Asp Val Thr Pro Pro Pro Asp Gly Ser Thr Thr
                645                 650                 655
His Asn Leu Glu Val Ser Pro Lys Glu Lys Gln Thr Glu Thr Ala Ala
            660                 665                 670
Asp Cys Arg Tyr Arg Pro Ser Val Asp Cys His Glu Lys Pro Leu Asn
        675                 680                 685
Leu Ser Val Gly Ala Leu His Asn Cys Pro Ala Ile Ser Leu Ser Lys
    690                 695                 700
Ser Leu Ile Pro Ser Ile Thr Cys Pro Phe Cys Thr Phe Lys Thr Phe
705                 710                 715                 720
Tyr Pro Glu Val Leu Met Met His Gln Arg Leu Glu His Lys Tyr Asn
                725                 730                 735
Pro Asp Val His Lys Asn Cys Arg Asn Lys Ser Leu Leu Arg Ser Arg
            740                 745                 750
Arg Thr Gly Cys Pro Pro Ala Leu Leu Gly Lys Asp Val Pro Pro Leu
        755                 760                 765
Ser Ser Phe Cys Lys Pro Lys Pro Lys Ser Ala Phe Pro Ala Gln Ser
    770                 775                 780
Lys Ser Leu Pro Ser Ala Lys Gly Lys Gln Ser Pro Pro Gly Pro Gly
785                 790                 795                 800
Lys Ala Pro Leu Thr Ser Gly Ile Asp Ser Ser Thr Leu Ala Pro Ser
                805                 810                 815
Asn Leu Lys Ser His Arg Pro Gln Gln Asn Val Gly Val Gln Gly Ala
            820                 825                 830
Ala Thr Arg Gln Gln Gln Ser Glu Met Phe Pro Lys Thr Ser Val Ser
        835                 840                 845
Pro Ala Pro Asp Lys Thr Lys Arg Pro Glu Thr Lys Leu Lys Pro Leu
    850                 855                 860
Pro Val Ala Pro Ser Gln Pro Thr Leu Gly Ser Ser Asn Ile Asn Gly
865                 870                 875                 880
Ser Ile Asp Tyr Pro Ala Lys Asn Asp Ser Pro Trp Ala Pro Pro Gly
                885                 890                 895
Arg Asp Tyr Phe Cys Asn Arg Ser Ala Ser Asn Thr Ala Ala Glu Phe
            900                 905                 910
Gly Glu Pro Leu Pro Lys Arg Leu Lys Ser Ser Val Val Ala Leu Asp
        915                 920                 925
Val Asp Gln Pro Gly Ala Asn Tyr Arg Arg Gly Tyr Asp Leu Pro Lys
    930                 935                 940
Tyr His Met Val Arg Gly Ile Thr Ser Leu Leu Pro Gln Asp Cys Val
945                 950                 955                 960
Tyr Pro Ser Gln Ala Leu Pro Pro Lys Pro Arg Phe Leu Ser Ser Ser
                965                 970                 975
Glu Val Asp Ser Pro Asn Val Leu Thr Val Gln Lys Pro Tyr Gly Gly
            980                 985                 990
Ser Gly Pro Leu Tyr Thr Cys Val Pro Ala Gly Ser Pro Ala Ser Ser
        995                 1000                1005
Ser Thr Leu Glu Gly Lys Arg Pro Val Ser Tyr Gln His Leu Ser Asn
    1010                1015                1020
Ser Met Ala Gln Lys Arg Asn Tyr Glu Asn Phe Ile Gly Asn Ala His
1025                1030                1035                1040
Tyr Arg Pro Asn Asp Lys Lys Thr
                1045

<210> 12
<211> 377
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Glu Pro Glu Glu Pro Ala Asp Ser Gly Gln Ser Leu Val Pro
 1               5                  10                  15
Val Tyr Ile Tyr Ser Pro Glu Tyr Val Ser Met Cys Asp Ser Leu Ala
            20                  25                  30
Lys Ile Pro Lys Arg Ala Ser Met Val His Ser Leu Ile Glu Ala Tyr
        35                  40                  45
Ala Leu His Lys Gln Met Arg Ile Val Lys Pro Lys Val Ala Ser Met
    50                  55                  60
Glu Glu Met Ala Thr Phe His Thr Asp Ala Tyr Leu Gln His Leu Gln
65                  70                  75                  80
Lys Val Ser Gln Glu Gly Asp Asp Asp His Pro Asp Ser Ile Glu Tyr
                85                  90                  95
Gly Leu Gly Tyr Asp Cys Pro Ala Thr Glu Gly Ile Phe Asp Tyr Ala
            100                 105                 110
Ala Ala Ile Gly Gly Ala Thr Ile Thr Ala Ala Gln Cys Leu Ile Asp
        115                 120                 125
Gly Met Cys Lys Val Ala Ile Asn Trp Ser Gly Gly Trp His His Ala
    130                 135                 140
Lys Lys Asp Glu Ala Ser Gly Phe Cys Tyr Leu Asn Asp Ala Val Leu
145                 150                 155                 160
Gly Ile Leu Arg Leu Arg Arg Lys Phe Glu Arg Ile Leu Tyr Val Asp
                165                 170                 175
Leu Asp Leu His His Gly Asp Gly Val Glu Asp Ala Phe Ser Phe Thr
            180                 185                 190
Ser Lys Val Met Thr Val Ser Leu His Lys Phe Ser Pro Gly Phe Phe
        195                 200                 205
Pro Gly Thr Gly Asp Val Ser Asp Val Gly Leu Gly Lys Gly Arg Tyr
    210                 215                 220
Tyr Ser Val Asn Val Pro Ile Gln Asp Gly Ile Gln Asp Glu Lys Tyr
225                 230                 235                 240
Tyr Gln Ile Cys Glu Ser Val Leu Lys Glu Val Tyr Gln Ala Phe Asn
                245                 250                 255
Pro Lys Ala Val Val Leu Gln Leu Gly Ala Asp Thr Ile Ala Gly Asp
            260                 265                 270
Pro Met Cys Ser Phe Asn Met Thr Pro Val Gly Ile Gly Lys Cys Leu
        275                 280                 285
Lys Tyr Ile Leu Gln Trp Gln Leu Ala Thr Leu Ile Leu Gly Gly Gly
    290                 295                 300
Gly Tyr Asn Leu Ala Asn Thr Ala Arg Cys Trp Thr Tyr Leu Thr Gly
305                 310                 315                 320
Val Ile Leu Gly Lys Thr Leu Ser Ser Glu Ile Pro Asp His Glu Phe
                325                 330                 335
Phe Thr Ala Tyr Gly Pro Asp Tyr Val Leu Glu Ile Thr Pro Ser Cys
            340                 345                 350
Arg Pro Asp Arg Asn Glu Pro His Arg Ile Gln Gln Ile Leu Asn Tyr
        355                 360                 365
Ile Lys Gly Asn Leu Lys His Val Val
    370                 375

<210> 13
<211> 453
<212> PRT
<213> Homo sapiens

<400> 13
Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro
 1               5                  10                  15
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly
            20                  25                  30
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp
        35                  40                  45
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg
    50                  55                  60
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg
65                  70                  75                  80
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp
                85                  90                  95
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn
            100                 105                 110
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val
        115                 120                 125
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys
    130                 135                 140
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala
145                 150                 155                 160
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro
                165                 170                 175
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu
            180                 185                 190
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala
        195                 200                 205
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala
    210                 215                 220
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met
225                 230                 235                 240
Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln
                245                 250                 255
Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala
            260                 265                 270
Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala
        275                 280                 285
Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser
    290                 295                 300
Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met
305                 310                 315                 320
His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly
                325                 330                 335
Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr
            340                 345                 350
Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro
        355                 360                 365
Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala
    370                 375                 380
Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg
385                 390                 395                 400
Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn
                405                 410                 415
Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His
            420                 425                 430
Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala
        435                 440                 445
Val Trp Arg Pro Tyr
    450

<210> 14
<211> 239
<212> PRT
<213> Homo sapiens

<400> 14
Met Leu Leu Gln Pro Ala Pro Cys Ala Pro Ser Ala Gly Phe Pro Arg
 1               5                  10                  15
Pro Leu Ala Ala Pro Gly Ala Met His Gly Ser Gln Lys Asp Thr Thr
            20                  25                  30
Phe Thr Lys Ile Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala
        35                  40                  45
Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val
    50                  55                  60
Val Ile Thr Asp Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val
65                  70                  75                  80
Thr Met Ala Asp Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn
                85                  90                  95
Pro Ile Ile Asp Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly
            100                 105                 110
Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln
        115                 120                 125
Leu His Pro Thr Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr
    130                 135                 140
Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala
145                 150                 155                 160
Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser
                165                 170                 175
Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr
            180                 185                 190
Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro
        195                 200                 205
Ala Ala Val Pro Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr
    210                 215                 220
Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln
225                 230                 235

<210> 15
<211> 182
<212> PRT
<213> Homo sapiens

<400> 15
Met Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu
 1               5                  10                  15
Phe Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe
            20                  25                  30
Arg Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys
        35                  40                  45
Arg Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu
    50                  55                  60
Ser Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr
65                  70                  75                  80
Pro Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr
                85                  90                  95
Leu Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly
            100                 105                 110
Trp Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp
        115                 120                 125
Glu Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu
    130                 135                 140
Glu Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His
145                 150                 155                 160
Arg Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly
                165                 170                 175
Lys Lys Thr Thr Arg Pro
            180

<210> 16
<211> 196
<212> PRT
<213> Homo sapiens

<400> 16
Met Ser Glu Gly Asp Ser Val Gly Glu Ser Val His Gly Lys Pro Ser
 1               5                  10                  15
Val Val Tyr Arg Phe Phe Thr Arg Leu Gly Gln Ile Tyr Gln Ser Trp
            20                  25                  30
Leu Asp Lys Ser Thr Pro Tyr Thr Ala Val Arg Trp Val Val Thr Leu
        35                  40                  45
Gly Leu Ser Phe Val Tyr Met Ile Arg Val Tyr Leu Leu Gln Gly Trp
    50                  55                  60
Tyr Ile Val Thr Tyr Ala Leu Gly Ile Tyr His Leu Asn Leu Phe Ile
65                  70                  75                  80
Ala Phe Leu Ser Pro Lys Val Asp Pro Ser Leu Met Glu Asp Ser Asp
                85                  90                  95
Asp Gly Pro Ser Leu Pro Thr Lys Gln Asn Glu Glu Phe Arg Pro Phe
            100                 105                 110
Ile Arg Arg Leu Pro Glu Phe Lys Phe Trp His Ala Ala Thr Lys Gly
        115                 120                 125
Ile Leu Val Ala Met Val Cys Thr Phe Phe Asp Ala Phe Asn Val Pro
    130                 135                 140
Val Phe Trp Pro Ile Leu Val Met Tyr Phe Ile Met Leu Phe Cys Ile
145                 150                 155                 160
Thr Met Lys Arg Gln Ile Lys His Met Ile Lys Tyr Arg Tyr Ile Pro
                165                 170                 175
Phe Thr His Gly Lys Arg Arg Tyr Arg Gly Lys Glu Asp Ala Gly Lys
            180                 185                 190
Ala Phe Ala Ser
        195

<210> 17
<211> 519
<212> PRT
<213> Homo sapiens

<400> 17
Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu
 1               5                  10                  15
Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro
            20                  25                  30
Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys
        35                  40                  45
Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp
    50                  55                  60
Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu
65                  70                  75                  80
Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His
                85                  90                  95
Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu
            100                 105                 110
Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly
        115                 120                 125
Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro
    130                 135                 140
Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu
145                 150                 155                 160
Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His
                165                 170                 175
Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu
            180                 185                 190
Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg
        195                 200                 205
Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His
    210                 215                 220
Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val Ile
225                 230                 235                 240
Lys Glu Glu Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys Ile
                245                 250                 255
Gly Ser Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala
            260                 265                 270
Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Gly Leu
        275                 280                 285
Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu
    290                 295                 300
Met Met Lys Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn
305                 310                 315                 320
Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly
                325                 330                 335
Gly Ser Glu Val Val Pro Val Ile Ser Pro Met Tyr Gln Leu His Lys
            340                 345                 350
Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gln Asp Ser
        355                 360                 365
Ala Val Glu Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser
    370                 375                 380
Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr
385                 390                 395                 400
Glu Ser Asn Asn Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn
                405                 410                 415
His Ile Ala Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His
            420                 425                 430
Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala
        435                 440                 445
Leu Arg Val Val Ser Thr Ser Gly Glu Gln Met Lys Val Tyr Lys Cys
    450                 455                 460
Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His
465                 470                 475                 480
Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly
                485                 490                 495
Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly
            500                 505                 510
Glu His Arg Phe His Met Ser
        515

<210> 18
<211> 234
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Glu Asn His Cys Glu Leu Leu Ser Pro Ala Arg Gly Gly Ile
 1               5                  10                  15
Gly Ala Gly Leu Gly Gly Gly Leu Cys Arg Arg Cys Ser Ala Gly Leu
            20                  25                  30
Gly Ala Leu Ala Gln Arg Pro Gly Ser Val Ser Lys Trp Val Arg Leu
        35                  40                  45
Asn Val Gly Gly Thr Tyr Phe Leu Thr Thr Arg Gln Thr Leu Cys Arg
    50                  55                  60
Asp Pro Lys Ser Phe Leu Tyr Arg Leu Cys Gln Ala Asp Pro Asp Leu
65                  70                  75                  80
Asp Ser Asp Lys Asp Glu Thr Gly Ala Tyr Leu Ile Asp Arg Asp Pro
                85                  90                  95
Thr Tyr Phe Gly Pro Val Leu Asn Tyr Leu Arg His Gly Lys Leu Val
            100                 105                 110
Ile Asn Lys Asp Leu Ala Glu Glu Gly Val Leu Glu Glu Ala Glu Phe
        115                 120                 125
Tyr Asn Ile Thr Ser Leu Ile Lys Leu Val Lys Asp Lys Ile Arg Glu
    130                 135                 140
Arg Asp Ser Lys Thr Ser Gln Val Pro Val Lys His Val Tyr Arg Val
145                 150                 155                 160
Leu Gln Cys Gln Glu Glu Glu Leu Thr Gln Met Val Ser Thr Met Ser
                165                 170                 175
Asp Gly Trp Lys Phe Glu Gln Leu Val Ser Ile Gly Ser Ser Tyr Asn
            180                 185                 190
Tyr Gly Asn Glu Asp Gln Ala Glu Phe Leu Cys Val Val Ser Lys Glu
        195                 200                 205
Leu His Asn Thr Pro Tyr Gly Thr Ala Ser Glu Pro Ser Glu Lys Ala
    210                 215                 220
Lys Ile Leu Gln Glu Arg Gly Ser Arg Met
225                 230

<210> 19
<211> 406
<212> PRT
<213> Homo sapiens

<400> 19
Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val
 1               5                  10                  15
Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly
            20                  25                  30
Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu
        35                  40                  45
Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser
    50                  55                  60
Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser
65                  70                  75                  80
Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp
                85                  90                  95
Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile
            100                 105                 110
Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly
        115                 120                 125
Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu
    130                 135                 140
Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe
145                 150                 155                 160
Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr
                165                 170                 175
Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser
            180                 185                 190
Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val
        195                 200                 205
Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly
    210                 215                 220
Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu
225                 230                 235                 240
Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val
                245                 250                 255
Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn
            260                 265                 270
Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His
        275                 280                 285
Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu
    290                 295                 300
Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro
305                 310                 315                 320
Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp
                325                 330                 335
Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val
            340                 345                 350
Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala
        355                 360                 365
Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln
    370                 375                 380
Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly
385                 390                 395                 400
Phe Arg Thr Ile His Cys
                405

<210> 20
<211> 475
<212> PRT
<213> Homo sapiens

<400> 20
Met Ser Arg Arg Lys Ala Gly Ser Ala Pro Arg Arg Val Glu Pro Ala
 1               5                  10                  15
Pro Ala Ala Asn Pro Asp Asp Glu Met Glu Met Gln Asp Leu Val Ile
            20                  25                  30
Glu Leu Lys Pro Glu Pro Asp Ala Gln Pro Gln Gln Ala Pro Arg Leu
        35                  40                  45
Gly Pro Phe Ser Pro Lys Glu Val Ser Ser Ala Gly Arg Phe Gly Gly
    50                  55                  60
Glu Pro His His Ser Pro Gly Pro Met Pro Ala Gly Ala Ala Leu Leu
65                  70                  75                  80
Ala Leu Gly Pro Arg Asn Pro Trp Thr Leu Trp Thr Pro Leu Thr Pro
                85                  90                  95
Asn Tyr Pro Asp Arg Gln Pro Trp Thr Asp Lys His Pro Asp Leu Leu
            100                 105                 110
Thr Cys Gly Arg Cys Leu Gln Thr Phe Pro Leu Glu Ala Ile Thr Ala
        115                 120                 125
Phe Met Asp His Lys Lys Leu Gly Cys Gln Leu Phe Arg Gly Pro Ser
    130                 135                 140
Arg Gly Gln Gly Ser Glu Arg Glu Glu Leu Lys Ala Leu Ser Cys Leu
145                 150                 155                 160
Arg Cys Gly Lys Gln Phe Thr Val Ala Trp Lys Leu Leu Arg His Ala
                165                 170                 175
Gln Trp Asp His Gly Leu Ser Ile Tyr Gln Thr Glu Ser Glu Ala Pro
            180                 185                 190
Glu Ala Pro Leu Leu Gly Leu Ala Glu Val Ala Ala Ala Val Ser Ala
        195                 200                 205
Val Val Gly Pro Ala Ala Glu Ala Lys Ser Pro Arg Ala Ser Gly Ser
    210                 215                 220
Gly Leu Thr Arg Arg Ser Pro Thr Cys Pro Val Cys Lys Lys Thr Leu
225                 230                 235                 240
Ser Ser Phe Ser Asn Leu Lys Val His Met Arg Ser His Thr Gly Glu
                245                 250                 255
Arg Pro Tyr Ala Cys Asp Gln Cys Pro Tyr Ala Cys Ala Gln Ser Ser
            260                 265                 270
Lys Leu Asn Arg His Lys Lys Thr His Arg Gln Val Pro Pro Gln Ser
        275                 280                 285
Pro Leu Met Ala Asp Thr Ser Gln Glu Gln Ala Ser Ala Ala Pro Pro
    290                 295                 300
Glu Pro Ala Val His Ala Ala Ala Pro Thr Ser Thr Leu Pro Cys Ser
305                 310                 315                 320
Gly Gly Glu Gly Ala Gly Ala Ala Ala Thr Ala Gly Val Gln Glu Pro
                325                 330                 335
Gly Ala Pro Gly Ser Gly Ala Gln Ala Gly Pro Gly Gly Asp Thr Trp
            340                 345                 350
Gly Ala Ile Thr Thr Glu Gln Arg Thr Asp Pro Ala Asn Ser Gln Lys
        355                 360                 365
Ala Ser Pro Lys Lys Met Pro Lys Ser Gly Gly Lys Ser Arg Gly Pro
    370                 375                 380
Gly Gly Ser Cys Glu Phe Cys Gly Lys His Phe Thr Asn Ser Ser Asn
385                 390                 395                 400
Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg Pro Tyr Thr Cys
                405                 410                 415
Glu Phe Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu Asn Arg His
            420                 425                 430
Arg Arg Met His Gly Met Thr Pro Gly Ser Thr Arg Phe Glu Cys Pro
        435                 440                 445
His Cys His Val Pro Phe Gly Leu Arg Ala Thr Leu Asp Lys His Leu
    450                 455                 460
Arg Gln Lys His Pro Glu Ala Ala Gly Glu Ala
465                 470                 475

<210> 21
<211> 317
<212> PRT
<213> Homo sapiens

<400> 21
Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro
 1               5                  10                  15
Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser
            20                  25                  30
Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu
        35                  40                  45
Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu
    50                  55                  60
Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu
65                  70                  75                  80
Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln
                85                  90                  95
Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln
            100                 105                 110
Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu
        115                 120                 125
Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly
    130                 135                 140
Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val
145                 150                 155                 160
Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu
                165                 170                 175
Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile
            180                 185                 190
His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp
        195                 200                 205
Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala
    210                 215                 220
Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly
225                 230                 235                 240
Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu
                245                 250                 255
Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu
            260                 265                 270
Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser
        275                 280                 285
Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro
    290                 295                 300
Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu
305                 310                 315

<210> 22
<211> 592
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Pro Gly Gln Leu Ala Leu Phe Ser Val Ser Asp Lys Thr Gly
 1               5                  10                  15
Leu Val Glu Phe Ala Arg Asn Leu Thr Ala Leu Gly Leu Asn Leu Val
            20                  25                  30
Ala Ser Gly Gly Thr Ala Lys Ala Leu Arg Asp Ala Gly Leu Ala Val
        35                  40                  45
Arg Asp Val Ser Glu Leu Thr Gly Phe Pro Glu Met Leu Gly Gly Arg
    50                  55                  60
Val Lys Thr Leu His Pro Ala Val His Ala Gly Ile Leu Ala Arg Asn
65                  70                  75                  80
Ile Pro Glu Asp Asn Ala Asp Met Ala Arg Leu Asp Phe Asn Leu Ile
                85                  90                  95
Arg Val Val Ala Cys Asn Leu Tyr Pro Phe Val Lys Thr Val Ala Ser
            100                 105                 110
Pro Gly Val Thr Val Glu Glu Ala Val Glu Gln Ile Asp Ile Gly Gly
        115                 120                 125
Val Thr Leu Leu Arg Ala Ala Ala Lys Asn His Ala Arg Val Thr Val
    130                 135                 140
Val Cys Glu Pro Glu Asp Tyr Val Val Val Ser Thr Glu Met Gln Ser
145                 150                 155                 160
Ser Glu Ser Lys Asp Thr Ser Leu Glu Thr Arg Arg Gln Leu Ala Leu
                165                 170                 175
Lys Ala Phe Thr His Thr Ala Gln Tyr Asp Glu Ala Ile Ser Asp Tyr
            180                 185                 190
Phe Arg Lys Gln Tyr Ser Lys Gly Val Ser Gln Met Pro Leu Arg Tyr
        195                 200                 205
Gly Met Asn Pro His Gln Thr Pro Ala Gln Leu Tyr Thr Leu Gln Pro
    210                 215                 220
Lys Leu Pro Ile Thr Val Leu Asn Gly Ala Pro Gly Phe Ile Asn Leu
225                 230                 235                 240
Cys Asp Ala Leu Asn Ala Trp Gln Leu Val Lys Glu Leu Lys Glu Ala
                245                 250                 255
Leu Gly Ile Pro Ala Ala Ala Ser Phe Lys His Val Ser Pro Ala Gly
            260                 265                 270
Ala Ala Val Gly Ile Pro Leu Ser Glu Asp Glu Ala Lys Val Cys Met
        275                 280                 285
Val Tyr Asp Leu Tyr Lys Thr Leu Thr Pro Ile Ser Ala Ala Tyr Ala
    290                 295                 300
Arg Ala Arg Gly Ala Asp Arg Met Ser Ser Phe Gly Asp Phe Val Ala
305                 310                 315                 320
Leu Ser Asp Val Cys Asp Val Pro Thr Ala Lys Ile Ile Ser Arg Glu
                325                 330                 335
Val Ser Asp Gly Ile Ile Ala Pro Gly Tyr Glu Glu Glu Ala Leu Thr
            340                 345                 350
Ile Leu Ser Lys Lys Lys Asn Gly Asn Tyr Cys Val Leu Gln Met Asp
        355                 360                 365
Gln Ser Tyr Lys Pro Asp Glu Asn Glu Val Arg Thr Leu Phe Gly Leu
    370                 375                 380
His Leu Ser Gln Lys Arg Asn Asn Gly Val Val Asp Lys Ser Leu Phe
385                 390                 395                 400
Ser Asn Val Val Thr Lys Asn Lys Asp Leu Pro Glu Ser Ala Leu Arg
                405                 410                 415
Asp Leu Ile Val Ala Thr Ile Ala Val Lys Tyr Thr Gln Ser Asn Ser
            420                 425                 430
Val Cys Tyr Ala Lys Asn Gly Gln Val Ile Gly Ile Gly Ala Gly Gln
        435                 440                 445
Gln Ser Arg Ile His Cys Thr Arg Leu Ala Gly Asp Lys Ala Asn Tyr
    450                 455                 460
Trp Trp Leu Arg His His Pro Gln Val Leu Ser Met Lys Phe Lys Thr
465                 470                 475                 480
Gly Val Lys Arg Ala Glu Ile Ser Asn Ala Ile Asp Gln Tyr Val Thr
                485                 490                 495
Gly Thr Ile Gly Glu Asp Glu Asp Leu Ile Lys Trp Lys Ala Leu Phe
            500                 505                 510
Glu Glu Val Pro Glu Leu Leu Thr Glu Ala Glu Lys Lys Glu Trp Val
        515                 520                 525
Glu Lys Leu Thr Glu Val Ser Ile Ser Ser Asp Ala Phe Phe Pro Phe
    530                 535                 540
Arg Asp Asn Val Asp Arg Ala Lys Arg Ser Gly Val Ala Tyr Ile Ala
545                 550                 555                 560
Ala Pro Ser Gly Ser Ala Ala Asp Lys Val Val Ile Glu Ala Cys Asp
                565                 570                 575
Glu Leu Gly Ile Ile Leu Ala His Thr Asn Leu Arg Leu Phe His His
            580                 585                 590

<210> 23
<211> 375
<212> PRT
<213> Homo sapiens

<400> 23
Met Met Glu Asp Asp Gly Gln Pro Arg Thr Leu Tyr Val Gly Asn Leu
 1               5                  10                  15
Ser Arg Asp Val Thr Glu Val Leu Ile Leu Gln Leu Phe Ser Gln Ile
            20                  25                  30
Gly Pro Cys Lys Ser Cys Lys Met Ile Thr Glu His Thr Ser Asn Asp
        35                  40                  45
Pro Tyr Cys Phe Val Glu Phe Tyr Glu His Arg Asp Ala Ala Ala Ala
    50                  55                  60
Leu Ala Ala Met Asn Gly Arg Lys Ile Leu Gly Lys Glu Val Lys Val
65                  70                  75                  80
Asn Trp Ala Thr Thr Pro Ser Ser Gln Lys Lys Asp Thr Ser Asn His
                85                  90                  95
Phe His Val Phe Val Gly Asp Leu Ser Pro Glu Ile Thr Thr Glu Asp
            100                 105                 110
Ile Lys Ser Ala Phe Ala Pro Phe Gly Lys Ile Ser Asp Ala Arg Val
        115                 120                 125
Val Lys Asp Met Ala Thr Gly Lys Ser Lys Gly Tyr Gly Phe Val Ser
    130                 135                 140
Phe Tyr Asn Lys Leu Asp Ala Glu Asn Ala Ile Val His Met Gly Gly
145                 150                 155                 160
Gln Trp Leu Gly Gly Arg Gln Ile Arg Thr Asn Trp Ala Thr Arg Lys
                165                 170                 175
Pro Pro Ala Pro Lys Ser Thr Gln Glu Asn Asn Thr Lys Gln Leu Arg
            180                 185                 190
Phe Glu Asp Val Val Asn Gln Ser Ser Pro Lys Asn Cys Thr Val Tyr
        195                 200                 205
Cys Gly Gly Ile Ala Ser Gly Leu Thr Asp Gln Leu Met Arg Gln Thr
    210                 215                 220
Phe Ser Pro Phe Gly Gln Ile Met Glu Ile Arg Val Phe Pro Glu Lys
225                 230                 235                 240
Gly Tyr Ser Phe Val Arg Phe Ser Thr His Glu Ser Ala Ala His Ala
                245                 250                 255
Ile Val Ser Val Asn Gly Thr Thr Ile Glu Gly His Val Val Lys Cys
            260                 265                 270
Tyr Trp Gly Lys Glu Ser Pro Asp Met Thr Lys Asn Phe Gln Gln Val
        275                 280                 285
Asp Tyr Ser Gln Trp Gly Gln Trp Ser Gln Val Tyr Gly Asn Pro Gln
    290                 295                 300
Gln Tyr Gly Gln Tyr Met Ala Asn Gly Trp Gln Val Pro Pro Tyr Gly
305                 310                 315                 320
Val Tyr Gly Gln Pro Trp Asn Gln Gln Gly Phe Gly Val Asp Gln Ser
                325                 330                 335
Pro Ser Ala Ala Trp Met Gly Gly Phe Gly Ala Gln Pro Pro Gln Gly
            340                 345                 350
Gln Ala Pro Pro Pro Val Ile Pro Pro Pro Asn Gln Ala Gly Tyr Gly
        355                 360                 365
Met Ala Ser Tyr Gln Thr Gln
    370                 375

<210> 24
<211> 434
<212> PRT
<213> Homo sapiens

<400> 24
Met Asp Ser Val Glu Lys Gly Ala Ala Thr Ser Val Ser Asn Pro Arg
 1               5                  10                  15
Gly Arg Pro Ser Arg Gly Arg Pro Pro Lys Leu Gln Arg Asn Ser Arg
            20                  25                  30
Gly Gly Gln Gly Arg Gly Val Glu Lys Pro Pro His Leu Ala Ala Leu
        35                  40                  45
Ile Leu Ala Arg Gly Gly Ser Lys Gly Ile Pro Leu Lys Asn Ile Lys
    50                  55                  60
His Leu Ala Gly Val Pro Leu Ile Gly Trp Val Leu Arg Ala Ala Leu
65                  70                  75                  80
Asp Ser Gly Ala Phe Gln Ser Val Trp Val Ser Thr Asp His Asp Glu
                85                  90                  95
Ile Glu Asn Val Ala Lys Gln Phe Gly Ala Gln Val His Arg Arg Ser
            100                 105                 110
Ser Glu Val Ser Lys Asp Ser Ser Thr Ser Leu Asp Ala Ile Ile Glu
        115                 120                 125
Phe Leu Asn Tyr His Asn Glu Val Asp Ile Val Gly Asn Ile Gln Ala
    130                 135                 140
Thr Ser Pro Cys Leu His Pro Thr Asp Leu Gln Lys Val Ala Glu Met
145                 150                 155                 160
Ile Arg Glu Glu Gly Tyr Asp Ser Val Phe Ser Val Val Arg Arg His
                165                 170                 175
Gln Phe Arg Trp Ser Glu Ile Gln Lys Gly Val Arg Glu Val Thr Glu
            180                 185                 190
Pro Leu Asn Leu Asn Pro Ala Lys Arg Pro Arg Arg Gln Asp Trp Asp
        195                 200                 205
Gly Glu Leu Tyr Glu Asn Gly Ser Phe Tyr Phe Ala Lys Arg His Leu
    210                 215                 220
Ile Glu Met Gly Tyr Leu Gln Gly Gly Lys Met Ala Tyr Tyr Glu Met
225                 230                 235                 240
Arg Ala Glu His Ser Val Asp Ile Asp Val Asp Ile Asp Trp Pro Ile
                245                 250                 255
Ala Glu Gln Arg Val Leu Arg Tyr Gly Tyr Phe Gly Lys Glu Lys Leu
            260                 265                 270
Lys Glu Ile Lys Leu Leu Val Cys Asn Ile Asp Gly Cys Leu Thr Asn
        275                 280                 285
Gly His Ile Tyr Val Ser Gly Asp Gln Lys Glu Ile Ile Ser Tyr Asp
    290                 295                 300
Val Lys Asp Ala Ile Gly Ile Ser Leu Leu Lys Lys Ser Gly Ile Glu
305                 310                 315                 320
Val Arg Leu Ile Ser Glu Arg Ala Cys Ser Lys Gln Thr Leu Ser Ser
                325                 330                 335
Leu Lys Leu Asp Cys Lys Met Glu Val Ser Val Ser Asp Lys Leu Ala
            340                 345                 350
Val Val Asp Glu Trp Arg Lys Glu Met Gly Leu Cys Trp Lys Glu Val
        355                 360                 365
Ala Tyr Leu Gly Asn Glu Val Ser Asp Glu Glu Cys Leu Lys Arg Val
    370                 375                 380
Gly Leu Ser Gly Ala Pro Ala Asp Ala Cys Ser Thr Ala Gln Lys Ala
385                 390                 395                 400
Val Gly Tyr Ile Cys Lys Cys Asn Gly Gly Arg Gly Ala Ile Arg Glu
                405                 410                 415
Phe Ala Glu His Ile Cys Leu Leu Met Glu Lys Val Asn Asn Ser Cys
            420                 425                 430
Gln Lys


<210> 25
<211> 589
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Gly Leu Leu Lys Arg Lys Phe Asp Gln Leu Asp Glu Asp Asn
 1               5                  10                  15
Ser Ser Val Ser Ser Ser Ser Ser Ser Ser Gly Cys Gln Ser Arg Ser
            20                  25                  30
Cys Ser Pro Ser Ser Ser Val Ser Arg Ala Trp Asp Ser Glu Glu Glu
        35                  40                  45
Gly Pro Trp Asp Gln Met Pro Leu Pro Asp Arg Asp Phe Cys Gly Pro
    50                  55                  60
Arg Ser Phe Thr Pro Leu Ser Ile Leu Lys Arg Ala Arg Arg Glu Arg
65                  70                  75                  80
Pro Gly Arg Val Ala Phe Asp Gly Ile Thr Val Phe Tyr Phe Pro Arg
                85                  90                  95
Cys Gln Gly Phe Thr Ser Val Pro Ser Arg Gly Gly Cys Thr Leu Gly
            100                 105                 110
Met Ala Leu Arg His Ser Ala Cys Arg Arg Phe Ser Leu Ala Glu Phe
        115                 120                 125
Ala Gln Glu Gln Ala Arg Ala Arg His Glu Lys Leu Arg Gln Arg Leu
    130                 135                 140
Lys Glu Glu Lys Leu Glu Met Leu Gln Trp Lys Leu Ser Ala Ala Gly
145                 150                 155                 160
Val Pro Gln Ala Glu Ala Gly Leu Pro Pro Val Val Asp Ala Ile Asp
                165                 170                 175
Asp Ala Ser Val Glu Glu Asp Leu Ala Val Ala Val Ala Gly Gly Arg
            180                 185                 190
Leu Glu Glu Val Ser Phe Leu Gln Pro Tyr Pro Ala Arg Arg Arg Arg
        195                 200                 205
Ala Leu Leu Arg Ala Ser Gly Val Arg Arg Ile Asp Arg Glu Glu Lys
    210                 215                 220
Arg Glu Leu Gln Ala Leu Arg Gln Ser Arg Glu Asp Cys Gly Cys His
225                 230                 235                 240
Cys Asp Arg Ile Cys Asp Pro Glu Thr Cys Ser Cys Ser Leu Ala Gly
                245                 250                 255
Ile Lys Cys Gln Met Asp His Thr Ala Phe Pro Cys Gly Cys Cys Arg
            260                 265                 270
Glu Gly Cys Glu Asn Pro Met Gly Arg Val Glu Phe Asn Gln Ala Arg
        275                 280                 285
Val Gln Thr His Phe Ile His Thr Leu Thr Arg Leu Gln Leu Glu Gln
    290                 295                 300
Glu Ala Glu Ser Phe Arg Glu Leu Glu Ala Pro Ala Gln Gly Ser Pro
305                 310                 315                 320
Pro Ser Pro Gly Glu Glu Ala Leu Val Pro Thr Phe Pro Leu Ala Lys
                325                 330                 335
Pro Pro Met Asn Asn Glu Leu Gly Asp Asn Ser Cys Ser Ser Asp Met
            340                 345                 350
Thr Asp Ser Ser Thr Ala Ser Ser Ser Ala Ser Gly Thr Ser Glu Ala
        355                 360                 365
Pro Asp Cys Pro Thr His Pro Gly Leu Pro Gly Pro Gly Phe Gln Pro
    370                 375                 380
Gly Val Asp Asp Asp Ser Leu Ala Arg Ile Leu Ser Phe Ser Asp Ser
385                 390                 395                 400
Asp Phe Gly Gly Glu Glu Glu Glu Glu Glu Glu Gly Ser Val Gly Asn
                405                 410                 415
Leu Asp Asn Leu Ser Cys Phe His Pro Ala Asp Ile Phe Gly Thr Ser
            420                 425                 430
Asp Pro Gly Gly Leu Ala Ser Trp Thr His Ser Tyr Ser Gly Cys Ser
        435                 440                 445
Phe Thr Ser Gly Val Leu Asp Glu Asn Ala Asn Leu Asp Ala Ser Cys
    450                 455                 460
Phe Leu Asn Gly Gly Leu Glu Gly Ser Arg Glu Gly Ser Leu Pro Gly
465                 470                 475                 480
Thr Ser Val Pro Pro Ser Met Asp Ala Gly Arg Ser Ser Ser Val Asp
                485                 490                 495
Leu Ser Leu Ser Ser Cys Asp Ser Phe Glu Leu Leu Gln Ala Leu Pro
            500                 505                 510
Asp Tyr Ser Leu Gly Pro His Tyr Thr Ser Gln Lys Val Ser Asp Ser
        515                 520                 525
Leu Asp Asn Ile Glu Ala Pro His Phe Pro Leu Pro Gly Leu Ser Pro
    530                 535                 540
Pro Gly Asp Ala Ser Ser Cys Phe Leu Glu Ser Leu Met Gly Phe Ser
545                 550                 555                 560
Glu Pro Ala Ala Glu Ala Leu Asp Pro Phe Ile Asp Ser Gln Phe Glu
                565                 570                 575
Asp Thr Val Pro Ala Ser Leu Met Glu Pro Val Pro Val
            580                 585

<210> 26
<211> 165
<212> PRT
<213> Homo sapiens

<400> 26
Met Thr Leu Glu Glu Phe Ser Ala Gly Glu Gln Lys Thr Glu Arg Met
 1               5                  10                  15
Asp Lys Val Gly Asp Ala Leu Glu Glu Val Leu Ser Lys Ala Leu Ser
            20                  25                  30
Gln Arg Thr Ile Thr Val Gly Val Tyr Glu Ala Ala Lys Leu Leu Asn
        35                  40                  45
Val Asp Pro Asp Asn Val Val Leu Cys Leu Leu Ala Ala Asp Glu Asp
    50                  55                  60
Asp Asp Arg Asp Val Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ala
65                  70                  75                  80
Phe Cys Cys Glu Asn Asp Ile Asn Ile Leu Arg Val Ser Asn Pro Gly
                85                  90                  95
Arg Leu Ala Glu Leu Leu Leu Leu Glu Thr Asp Ala Gly Pro Ala Ala
            100                 105                 110
Ser Glu Gly Ala Glu Gln Pro Pro Asp Leu His Cys Val Leu Val Thr
        115                 120                 125
Asn Pro His Ser Ser Gln Trp Lys Asp Pro Ala Leu Ser Gln Leu Ile
    130                 135                 140
Cys Phe Cys Arg Glu Ser Arg Tyr Met Asp Gln Trp Val Pro Val Ile
145                 150                 155                 160
Asn Leu Pro Glu Arg
                165

<210> 27
<211> 932
<212> PRT
<213> Homo sapiens

<400> 27
Met Ser Glu Ala Gly Gly Arg Gly Cys Gly Ser Pro Val Pro Gln Arg
 1               5                  10                  15
Ala Arg Trp Arg Leu Val Ala Ala Thr Ala Ala Phe Cys Leu Val Ser
            20                  25                  30
Ala Thr Ser Val Trp Thr Ala Gly Ala Glu Pro Met Ser Arg Glu Glu
        35                  40                  45
Lys Gln Lys Leu Gly Asn Gln Val Leu Glu Met Phe Asp His Ala Tyr
    50                  55                  60
Gly Asn Tyr Met Glu His Ala Tyr Pro Ala Asp Glu Leu Met Pro Leu
65                  70                  75                  80
Thr Cys Arg Gly Arg Val Arg Gly Gln Glu Pro Ser Arg Gly Asp Val
                85                  90                  95
Asp Asp Ala Leu Gly Lys Phe Ser Leu Thr Leu Ile Asp Ser Leu Asp
            100                 105                 110
Thr Leu Val Val Leu Asn Lys Thr Lys Glu Phe Glu Asp Ala Val Arg
        115                 120                 125
Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp Val Val Val Ser Val
    130                 135                 140
Phe Glu Thr Asn Ile Arg Val Leu Gly Gly Leu Leu Gly Gly His Ser
145                 150                 155                 160
Leu Ala Ile Met Leu Lys Glu Lys Gly Glu Tyr Met Gln Trp Tyr Asn
                165                 170                 175
Asp Glu Leu Leu Gln Met Ala Lys Gln Leu Gly Tyr Lys Leu Leu Pro
            180                 185                 190
Ala Phe Asn Thr Thr Ser Gly Leu Pro Tyr Pro Arg Ile Asn Leu Lys
        195                 200                 205
Phe Gly Ile Arg Lys Pro Glu Ala Arg Thr Gly Thr Glu Thr Asp Thr
    210                 215                 220
Cys Thr Ala Cys Ala Gly Thr Leu Ile Leu Glu Phe Ala Ala Leu Ser
225                 230                 235                 240
Arg Phe Thr Gly Ala Thr Ile Phe Glu Glu Tyr Ala Arg Lys Ala Leu
                245                 250                 255
Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser Asn Leu Val Gly Val
            260                 265                 270
Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg Lys Asp Ser Gly Val
        275                 280                 285
Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu Leu Lys Ala Tyr Val
    290                 295                 300
Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe Asn Thr His Tyr Asp
305                 310                 315                 320
Ala Ile Met Arg Tyr Ile Ser Gln Pro Pro Leu Leu Leu Asp Val His
                325                 330                 335
Ile His Lys Pro Met Leu Asn Ala Arg Thr Trp Met Asp Ala Leu Leu
            340                 345                 350
Ala Phe Phe Pro Gly Leu Gln Val Leu Lys Gly Asp Ile Arg Pro Ala
        355                 360                 365
Ile Glu Thr His Glu Met Leu Tyr Gln Val Ile Lys Lys His Asn Phe
    370                 375                 380
Leu Pro Glu Ala Phe Thr Thr Asp Phe Arg Val His Trp Ala Gln His
385                 390                 395                 400
Pro Leu Arg Pro Glu Phe Ala Glu Ser Thr Tyr Phe Leu Tyr Lys Ala
                405                 410                 415
Thr Gly Asp Pro Tyr Tyr Leu Glu Val Gly Lys Thr Leu Ile Glu Asn
            420                 425                 430
Leu Asn Lys Tyr Ala Arg Val Pro Cys Gly Phe Ala Ala Met Lys Asp
        435                 440                 445
Val Arg Thr Gly Ser His Glu Asp Arg Met Asp Ser Phe Phe Leu Ala
    450                 455                 460
Glu Met Phe Lys Tyr Leu Tyr Leu Leu Phe Ala Asp Lys Glu Asp Ile
465                 470                 475                 480
Ile Phe Asp Ile Glu Asp Tyr Ile Phe Thr Thr Glu Ala His Leu Leu
                485                 490                 495
Pro Leu Trp Leu Ser Thr Thr Asn Gln Ser Ile Ser Lys Lys Asn Thr
            500                 505                 510
Thr Ser Glu Tyr Thr Glu Leu Asp Asp Ser Asn Phe Asp Trp Thr Cys
        515                 520                 525
Pro Asn Thr Gln Ile Leu Phe Pro Asn Asp Pro Leu Tyr Ala Gln Ser
    530                 535                 540
Ile Arg Glu Pro Leu Lys Asn Val Val Asp Lys Ser Cys Pro Arg Gly
545                 550                 555                 560
Ile Ile Arg Val Glu Glu Ser Phe Arg Ser Gly Ala Lys Pro Pro Leu
                565                 570                 575
Arg Ala Arg Asp Phe Met Ala Thr Asn Pro Glu His Leu Glu Ile Leu
            580                 585                 590
Lys Lys Met Gly Val Ser Leu Ile His Leu Lys Asp Gly Arg Val Gln
        595                 600                 605
Leu Val Gln His Ala Ile Gln Ala Ala Ser Ser Ile Asp Ala Glu Asp
    610                 615                 620
Gly Leu Arg Phe Met Gln Glu Met Ile Glu Leu Ser Ser Gln Gln Gln
625                 630                 635                 640
Lys Glu Gln Gln Leu Pro Pro Arg Ala Val Gln Ile Val Ser His Pro
                645                 650                 655
Phe Phe Gly Arg Val Val Leu Thr Ala Gly Pro Ala Gln Phe Gly Leu
            660                 665                 670
Asp Leu Ser Lys His Lys Glu Thr Arg Gly Phe Val Ala Ser Ser Lys
        675                 680                 685
Pro Ser Asn Gly Cys Ser Glu Leu Thr Asn Pro Glu Ala Val Met Gly
    690                 695                 700
Lys Ile Ala Leu Ile Gln Arg Gly Gln Cys Met Phe Ala Glu Lys Ala
705                 710                 715                 720
Arg Asn Ile Gln Asn Ala Gly Ala Ile Gly Gly Ile Val Ile Asp Asp
                725                 730                 735
Asn Glu Gly Ser Ser Ser Asp Thr Ala Pro Leu Phe Gln Met Ala Gly
            740                 745                 750
Asp Gly Lys Asp Thr Asp Asp Ile Lys Ile Pro Met Leu Phe Leu Phe
        755                 760                 765
Ser Lys Glu Gly Ser Ile Ile Leu Asp Ala Ile Arg Glu Tyr Glu Glu
    770                 775                 780
Val Glu Val Leu Leu Ser Asp Lys Ala Lys Asp Arg Asp Pro Glu Met
785                 790                 795                 800
Glu Asn Glu Glu Gln Pro Ser Ser Glu Asn Asp Ser Gln Asn Gln Ser
                805                 810                 815
Gly Glu Gln Ile Ser Ser Ser Ser Gln Glu Val Asp Leu Val Asp Gln
            820                 825                 830
Glu Ser Ser Glu Glu Asn Ser Leu Asn Ser His Pro Glu Ser Leu Ser
        835                 840                 845
Leu Ala Asp Met Asp Asn Ala Ala Ser Ile Ser Pro Ser Glu Gln Thr
    850                 855                 860
Ser Asn Pro Thr Glu Asn His Glu Thr Thr Asn Leu Asn Gly Glu Cys
865                 870                 875                 880
Thr Asp Leu Asp Asn Gln Leu Gln Glu Gln Ser Glu Thr Glu Glu Asp
                885                 890                 895
Ser Asn Pro Asn Val Ser Trp Gly Lys Lys Val Gln Pro Ile Asp Ser
            900                 905                 910
Ile Leu Ala Asp Trp Asn Glu Asp Ile Glu Ala Phe Glu Met Met Glu
        915                 920                 925
Lys Asp Glu Leu
    930

<210> 28
<211> 859
<212> PRT
<213> Homo sapiens

<400> 28
Met Tyr Ser Gly Ala Gly Pro Ala Leu Ala Pro Pro Ala Pro Pro Pro
 1               5                  10                  15
Pro Ile Gln Gly Tyr Ala Phe Lys Pro Pro Pro Arg Pro Asp Phe Gly
            20                  25                  30
Thr Ser Gly Arg Thr Ile Lys Leu Gln Ala Asn Phe Phe Glu Met Asp
        35                  40                  45
Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys Pro Glu
    50                  55                  60
Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met Val Gln
65                  70                  75                  80
His Phe Lys Thr Gln Ile Phe Gly Asp Arg Lys Pro Val Phe Asp Gly
                85                  90                  95
Arg Lys Asn Leu Tyr Thr Ala Met Pro Leu Pro Ile Gly Arg Asp Lys
            100                 105                 110
Val Glu Leu Glu Val Thr Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe
        115                 120                 125
Lys Val Ser Ile Lys Trp Val Ser Cys Val Ser Leu Gln Ala Leu His
    130                 135                 140
Asp Ala Leu Ser Gly Arg Leu Pro Ser Val Pro Phe Glu Thr Ile Gln
145                 150                 155                 160
Ala Leu Asp Val Val Met Arg His Leu Pro Ser Met Arg Tyr Thr Pro
                165                 170                 175
Val Gly Arg Ser Phe Phe Thr Ala Ser Glu Gly Cys Ser Asn Pro Leu
            180                 185                 190
Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro
        195                 200                 205
Ser Leu Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe
    210                 215                 220
Tyr Lys Ala Gln Pro Val Ile Glu Phe Val Cys Glu Val Leu Asp Phe
225                 230                 235                 240
Lys Ser Ile Glu Glu Gln Gln Lys Pro Leu Thr Asp Ser Gln Arg Val
                245                 250                 255
Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Ile Thr His Cys
            260                 265                 270
Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro
        275                 280                 285
Ala Ser His Gln Thr Phe Pro Leu Gln Gln Glu Ser Gly Gln Thr Val
    290                 295                 300
Glu Cys Thr Val Ala Gln Tyr Phe Lys Asp Arg His Lys Leu Val Leu
305                 310                 315                 320
Arg Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His
                325                 330                 335
Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys
            340                 345                 350
Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Arg Ala Thr
        355                 360                 365
Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Lys Leu Met Arg
    370                 375                 380
Ser Ala Ser Phe Asn Thr Asp Pro Tyr Val Arg Glu Phe Gly Ile Met
385                 390                 395                 400
Val Lys Asp Glu Met Thr Asp Val Thr Gly Arg Val Leu Gln Pro Pro
                405                 410                 415
Ser Ile Leu Tyr Gly Gly Arg Asn Lys Ala Ile Ala Thr Pro Val Gln
            420                 425                 430
Gly Val Trp Asp Met Arg Asn Lys Gln Phe His Thr Gly Ile Glu Ile
        435                 440                 445
Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Arg Gln Cys Thr Glu
    450                 455                 460
Val His Leu Lys Ser Phe Thr Glu Gln Leu Arg Lys Ile Ser Arg Asp
465                 470                 475                 480
Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln
                485                 490                 495
Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr
            500                 505                 510
Ala Gly Leu Gln Leu Val Val Val Ile Leu Pro Gly Lys Thr Pro Val
        515                 520                 525
Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Val Leu Gly Met Ala Thr
    530                 535                 540
Gln Cys Val Gln Met Lys Asn Val Gln Arg Thr Thr Pro Gln Thr Leu
545                 550                 555                 560
Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn
                565                 570                 575
Ile Leu Leu Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile
            580                 585                 590
Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys
        595                 600                 605
Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg
    610                 615                 620
Tyr Cys Ala Thr Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln
625                 630                 635                 640
Asp Leu Ala Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser
                645                 650                 655
Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser
            660                 665                 670
Glu Gly Gln Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg
        675                 680                 685
Glu Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Phe
    690                 695                 700
Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Thr Asp Lys
705                 710                 715                 720
Asn Glu Arg Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val
                725                 730                 735
Asp Thr Lys Ile Thr His Pro Thr Glu Phe Asp Phe Tyr Leu Cys Ser
            740                 745                 750
His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val Leu
        755                 760                 765
Trp Asp Asp Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Thr Tyr
    770                 775                 780
Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro
785                 790                 795                 800
Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His
                805                 810                 815
Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Thr Ser Gly
            820                 825                 830
Gln Ser Asn Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val
        835                 840                 845
His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala
    850                 855

<210> 29
<211> 299
<212> PRT
<213> Homo sapiens

<400> 29
Met Asp Leu Ser Glu Leu Glu Arg Asp Asn Thr Gly Arg Cys Arg Leu
 1               5                  10                  15
Ser Ser Pro Val Pro Ala Val Cys Arg Lys Glu Pro Cys Val Leu Gly
            20                  25                  30
Val Asp Glu Ala Gly Arg Gly Pro Val Leu Gly Pro Met Val Tyr Ala
        35                  40                  45
Ile Cys Tyr Cys Pro Leu Pro Arg Leu Ala Asp Leu Glu Ala Leu Lys
    50                  55                  60
Val Ala Asp Ser Lys Thr Leu Leu Glu Ser Glu Arg Glu Arg Leu Phe
65                  70                  75                  80
Ala Lys Met Glu Asp Thr Asp Phe Val Gly Trp Ala Leu Asp Val Leu
                85                  90                  95
Ser Pro Asn Leu Ile Ser Thr Ser Met Leu Gly Arg Val Lys Tyr Asn
            100                 105                 110
Leu Asn Ser Leu Ser His Asp Thr Ala Thr Gly Leu Ile Gln Tyr Ala
        115                 120                 125
Leu Asp Gln Gly Val Asn Val Thr Gln Val Phe Val Asp Thr Val Gly
    130                 135                 140
Met Pro Glu Thr Tyr Gln Ala Arg Leu Gln Gln Ser Phe Pro Gly Ile
145                 150                 155                 160
Glu Val Thr Val Lys Ala Lys Ala Asp Ala Leu Tyr Pro Val Val Ser
                165                 170                 175
Ala Ala Ser Ile Cys Ala Lys Val Ala Arg Asp Gln Ala Val Lys Lys
            180                 185                 190
Trp Gln Phe Val Glu Lys Leu Gln Asp Leu Asp Thr Asp Tyr Gly Ser
        195                 200                 205
Gly Tyr Pro Asn Asp Pro Lys Thr Lys Ala Trp Leu Lys Glu His Val
    210                 215                 220
Glu Pro Val Phe Gly Phe Pro Gln Phe Val Arg Phe Ser Trp Arg Thr
225                 230                 235                 240
Ala Gln Thr Ile Leu Glu Lys Glu Ala Glu Asp Val Ile Trp Glu Asp
                245                 250                 255
Ser Ala Ser Glu Asn Gln Glu Gly Leu Arg Lys Ile Thr Ser Tyr Phe
            260                 265                 270
Leu Asn Glu Gly Ser Gln Ala Arg Pro Arg Ser Ser His Arg Tyr Phe
        275                 280                 285
Leu Glu Arg Gly Leu Glu Ser Ala Thr Ser Leu
    290                 295

<210> 30
<211> 318
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Pro Trp Ala Glu Ala Glu His Ser Ala Leu Asn Pro Leu Arg
 1               5                  10                  15
Ala Val Trp Leu Thr Leu Thr Ala Ala Phe Leu Leu Thr Leu Leu Leu
            20                  25                  30
Gln Leu Leu Pro Pro Gly Leu Leu Pro Gly Cys Ala Ile Phe Gln Asp
        35                  40                  45
Leu Ile Arg Tyr Gly Lys Thr Lys Cys Gly Glu Pro Ser Arg Pro Ala
    50                  55                  60
Ala Cys Arg Ala Phe Asp Val Pro Lys Arg Tyr Phe Ser His Phe Tyr
65                  70                  75                  80
Ile Ile Ser Val Leu Trp Asn Gly Phe Leu Leu Trp Cys Leu Thr Gln
                85                  90                  95
Ser Leu Phe Leu Gly Ala Pro Phe Pro Ser Trp Leu His Gly Leu Leu
            100                 105                 110
Arg Ile Leu Gly Ala Ala Gln Phe Gln Gly Gly Glu Leu Ala Leu Ser
        115                 120                 125
Ala Phe Leu Val Leu Val Phe Leu Trp Leu His Ser Leu Arg Arg Leu
    130                 135                 140
Phe Glu Cys Leu Tyr Val Ser Val Phe Ser Asn Val Met Ile His Val
145                 150                 155                 160
Val Gln Tyr Cys Phe Gly Leu Val Tyr Tyr Val Leu Val Gly Leu Thr
                165                 170                 175
Val Leu Ser Gln Val Pro Met Asp Gly Arg Asn Ala Tyr Ile Thr Gly
            180                 185                 190
Lys Asn Leu Leu Met Gln Ala Arg Trp Phe His Ile Leu Gly Met Met
        195                 200                 205
Met Phe Ile Trp Ser Ser Ala His Gln Tyr Lys Cys His Val Ile Leu
    210                 215                 220
Gly Asn Leu Arg Lys Asn Lys Ala Gly Val Val Ile His Cys Asn His
225                 230                 235                 240
Arg Ile Pro Phe Gly Asp Trp Phe Glu Tyr Val Ser Ser Pro Asn Tyr
                245                 250                 255
Leu Ala Glu Leu Met Ile Tyr Val Ser Met Ala Val Thr Phe Gly Phe
            260                 265                 270
His Asn Leu Thr Trp Trp Leu Val Val Thr Asn Val Phe Phe Asn Gln
        275                 280                 285
Ala Leu Ser Ala Phe Leu Ser His Gln Phe Tyr Lys Ser Lys Phe Val
    290                 295                 300
Ser Tyr Pro Lys His Arg Lys Ala Phe Leu Pro Phe Leu Phe
305                 310                 315

<210> 31
<211> 895
<212> PRT
<213> Homo sapiens

<400> 31
Met Lys Ile Gly Ser Gly Phe Leu Ser Gly Gly Gly Gly Thr Gly Ser
 1               5                  10                  15
Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly
            20                  25                  30
Gly Gly Ser Ser Gly Arg Arg Ala Glu Met Glu Pro Thr Phe Pro Gln
        35                  40                  45
Gly Met Val Met Phe Asn His Arg Leu Pro Pro Val Thr Ser Phe Thr
    50                  55                  60
Arg Pro Ala Gly Ser Ala Ala Pro Pro Pro Gln Cys Val Leu Ser Ser
65                  70                  75                  80
Ser Thr Ser Ala Ala Pro Ala Ala Glu Pro Pro Pro Pro Pro Ala Pro
                85                  90                  95
Asp Met Thr Phe Lys Lys Glu Pro Ala Ala Ser Ala Ala Ala Phe Pro
            100                 105                 110
Ser Gln Arg Thr Ser Trp Gly Phe Leu Gln Ser Leu Val Ser Ile Lys
        115                 120                 125
Gln Glu Lys Pro Ala Asp Pro Glu Glu Gln Gln Ser His His His His
    130                 135                 140
His His His His Tyr Gly Gly Leu Phe Ala Gly Ala Glu Glu Arg Ser
145                 150                 155                 160
Pro Gly Leu Gly Gly Gly Glu Gly Gly Ser His Gly Val Ile Gln Asp
                165                 170                 175
Leu Ser Ile Leu His Gln His Val Gln Gln Gln Pro Ala Gln His His
            180                 185                 190
Arg Asp Val Leu Leu Ser Ser Ser Ser Arg Thr Asp Asp His His Gly
        195                 200                 205
Thr Glu Glu Pro Lys Gln Asp Thr Asn Val Lys Lys Ala Lys Arg Pro
    210                 215                 220
Lys Pro Glu Ser Gln Gly Ile Lys Ala Lys Arg Lys Pro Ser Ala Ser
225                 230                 235                 240
Ser Lys Pro Ser Leu Val Gly Asp Gly Glu Gly Ala Ile Leu Ser Pro
                245                 250                 255
Ser Gln Lys Pro His Ile Cys Asp His Cys Ser Ala Ala Phe Arg Ser
            260                 265                 270
Ser Tyr His Leu Arg Arg His Val Leu Ile His Thr Gly Glu Arg Pro
        275                 280                 285
Phe Gln Cys Ser Gln Cys Ser Met Gly Phe Ile Gln Lys Tyr Leu Leu
    290                 295                 300
Gln Arg His Glu Lys Ile His Ser Arg Glu Lys Pro Phe Gly Cys Asp
305                 310                 315                 320
Gln Cys Ser Met Lys Phe Ile Gln Lys Tyr His Met Glu Arg His Lys
                325                 330                 335
Arg Thr His Ser Gly Glu Lys Pro Tyr Lys Cys Asp Thr Cys Gln Gln
            340                 345                 350
Tyr Phe Ser Arg Thr Asp Arg Leu Leu Lys His Arg Arg Thr Cys Gly
        355                 360                 365
Glu Val Ile Val Lys Gly Ala Thr Ser Ala Glu Pro Gly Ser Ser Asn
    370                 375                 380
His Thr Asn Met Gly Asn Leu Ala Val Leu Ser Gln Gly Asn Thr Ser
385                 390                 395                 400
Ser Ser Arg Arg Lys Thr Lys Ser Lys Ser Ile Ala Ile Glu Asn Lys
                405                 410                 415
Glu Gln Lys Thr Gly Lys Thr Asn Glu Ser Gln Ile Ser Asn Asn Ile
            420                 425                 430
Asn Met Gln Ser Tyr Ser Val Glu Met Pro Thr Val Ser Ser Ser Gly
        435                 440                 445
Gly Ile Ile Gly Thr Gly Ile Asp Glu Leu Gln Lys Arg Val Pro Lys
    450                 455                 460
Leu Ile Phe Lys Lys Gly Ser Arg Lys Asn Thr Asp Lys Asn Tyr Leu
465                 470                 475                 480
Asn Phe Val Ser Pro Leu Pro Asp Ile Val Gly Gln Lys Ser Leu Ser
                485                 490                 495
Gly Lys Pro Ser Gly Ser Leu Gly Ile Val Ser Asn Asn Ser Val Glu
            500                 505                 510
Thr Ile Gly Leu Leu Gln Ser Thr Ser Gly Lys Gln Gly Gln Ile Ser
        515                 520                 525
Ser Asn Tyr Asp Asp Ala Met Gln Phe Ser Lys Lys Arg Arg Tyr Leu
    530                 535                 540
Pro Thr Ala Ser Ser Asn Ser Ala Phe Ser Ile Asn Val Gly His Met
545                 550                 555                 560
Val Ser Gln Gln Ser Val Ile Gln Ser Ala Gly Val Ser Val Leu Asp
                565                 570                 575
Asn Glu Ala Pro Leu Ser Leu Ile Asp Ser Ser Ala Leu Asn Ala Glu
            580                 585                 590
Ile Lys Ser Cys His Asp Lys Ser Gly Ile Pro Asp Glu Val Leu Gln
        595                 600                 605
Ser Ile Leu Asp Gln Tyr Ser Asn Lys Ser Glu Ser Gln Lys Glu Asp
    610                 615                 620
Pro Phe Asn Ile Ala Glu Pro Arg Val Asp Leu His Thr Ser Gly Glu
625                 630                 635                 640
His Ser Glu Leu Val Gln Glu Glu Asn Leu Ser Pro Gly Thr Gln Thr
                645                 650                 655
Pro Ser Asn Asp Lys Ala Ser Met Leu Gln Glu Tyr Ser Lys Tyr Leu
            660                 665                 670
Gln Gln Ala Phe Glu Lys Ser Thr Asn Ala Ser Phe Thr Leu Gly His
        675                 680                 685
Gly Phe Gln Phe Val Ser Leu Ser Ser Pro Leu His Asn His Thr Leu
    690                 695                 700
Phe Pro Glu Lys Gln Ile Tyr Thr Thr Ser Pro Leu Glu Cys Gly Phe
705                 710                 715                 720
Gly Gln Ser Val Thr Ser Val Leu Pro Ser Ser Leu Pro Lys Pro Pro
                725                 730                 735
Phe Gly Met Leu Phe Gly Ser Gln Pro Gly Leu Tyr Leu Ser Ala Leu
            740                 745                 750
Asp Ala Thr His Gln Gln Leu Thr Pro Ser Gln Glu Leu Asp Asp Leu
        755                 760                 765
Ile Asp Ser Gln Lys Asn Leu Glu Thr Ser Ser Ala Phe Gln Ser Ser
    770                 775                 780
Ser Gln Lys Leu Thr Ser Gln Lys Glu Gln Lys Asn Leu Glu Ser Ser
785                 790                 795                 800
Thr Gly Phe Gln Ile Pro Ser Gln Glu Leu Ala Ser Gln Ile Asp Pro
                805                 810                 815
Gln Lys Asp Ile Glu Pro Arg Thr Thr Tyr Gln Ile Glu Asn Phe Ala
            820                 825                 830
Gln Ala Phe Gly Ser Gln Phe Lys Ser Gly Ser Arg Val Pro Met Thr
        835                 840                 845
Phe Ile Thr Asn Ser Asn Gly Glu Val Asp His Arg Val Arg Thr Ser
    850                 855                 860
Val Ser Asp Phe Ser Gly Tyr Thr Asn Met Met Ser Asp Val Ser Glu
865                 870                 875                 880
Pro Cys Ser Thr Arg Val Lys Thr Pro Thr Ser Gln Ser Tyr Arg
                885                 890                 895

<210> 32
<211> 347
<212> PRT
<213> Homo sapiens

<400> 32
Met Glu Ser Pro Ala Ser Ser Gln Pro Ala Ser Met Pro Gln Ser Lys
 1               5                  10                  15
Gly Lys Ser Lys Arg Lys Lys Asp Leu Arg Ile Ser Cys Met Ser Lys
            20                  25                  30
Pro Pro Ala Pro Asn Pro Thr Pro Pro Arg Asn Leu Asp Ser Arg Thr
        35                  40                  45
Phe Ile Thr Ile Gly Asp Arg Asn Phe Glu Val Glu Ala Asp Asp Leu
    50                  55                  60
Val Thr Ile Ser Glu Leu Gly Arg Gly Ala Tyr Gly Val Val Glu Lys
65                  70                  75                  80
Val Arg His Ala Gln Ser Gly Thr Ile Met Ala Val Lys Arg Ile Arg
                85                  90                  95
Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu Leu Met Asp Leu Asp
            100                 105                 110
Ile Asn Met Arg Thr Val Asp Cys Phe Tyr Thr Val Thr Phe Tyr Gly
        115                 120                 125
Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys Met Glu Leu Met Asp
    130                 135                 140
Thr Ser Leu Asp Lys Phe Tyr Arg Lys Val Leu Asp Lys Asn Met Thr
145                 150                 155                 160
Ile Pro Glu Asp Ile Leu Gly Glu Ile Ala Val Ser Ile Val Arg Ala
                165                 170                 175
Leu Glu His Leu His Ser Lys Leu Ser Val Ile His Arg Asp Val Lys
            180                 185                 190
Pro Ser Asn Val Leu Ile Asn Lys Glu Gly His Val Lys Met Cys Asp
        195                 200                 205
Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val Ala Lys Thr Met Asp
    210                 215                 220
Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg Ile Asn Pro Glu Leu
225                 230                 235                 240
Asn Gln Lys Gly Tyr Asn Val Lys Ser Asp Val Trp Ser Leu Gly Ile
                245                 250                 255
Thr Met Ile Glu Met Ala Ile Leu Arg Phe Pro Tyr Glu Ser Trp Gly
            260                 265                 270
Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu Glu Pro Ser Pro Gln
        275                 280                 285
Leu Pro Ala Asp Arg Phe Ser Pro Glu Phe Val Asp Phe Thr Ala Gln
    290                 295                 300
Cys Leu Arg Lys Asn Pro Ala Glu Arg Met Ser Tyr Leu Glu Leu Met
305                 310                 315                 320
Glu His Pro Phe Phe Thr Leu His Lys Thr Lys Lys Thr Asp Ile Ala
                325                 330                 335
Ala Phe Val Lys Glu Ile Leu Gly Glu Asp Ser
            340                 345

<210> 33
<211> 414
<212> PRT
<213> Homo sapiens

<400> 33
Met Asn Leu Gln Arg Tyr Trp Gly Glu Ile Pro Ile Ser Ser Ser Gln
 1               5                  10                  15
Thr Asn Arg Ser Ser Phe Asp Leu Leu Pro Arg Glu Phe Arg Leu Val
            20                  25                  30
Glu Val His Asp Pro Pro Leu His Gln Pro Ser Ala Asn Lys Pro Lys
        35                  40                  45
Pro Pro Thr Met Leu Asp Ile Pro Ser Glu Pro Cys Ser Leu Thr Ile
    50                  55                  60
His Thr Ile Gln Leu Ile Gln His Asn Arg Arg Leu Arg Asn Leu Ile
65                  70                  75                  80
Ala Thr Ala Gln Ala Gln Asn Gln Gln Gln Thr Glu Gly Val Lys Thr
                85                  90                  95
Glu Glu Ser Glu Pro Leu Pro Ser Cys Pro Gly Ser Pro Pro Leu Pro
            100                 105                 110
Asp Asp Leu Leu Pro Leu Asp Cys Lys Asn Pro Asn Ala Pro Phe Gln
        115                 120                 125
Ile Arg His Ser Asp Pro Glu Ser Asp Phe Tyr Arg Gly Lys Gly Glu
    130                 135                 140
Pro Val Thr Glu Leu Ser Trp His Ser Cys Arg Gln Leu Leu Tyr Gln
145                 150                 155                 160
Ala Val Ala Thr Ile Leu Ala His Ala Gly Phe Asp Cys Ala Asn Glu
                165                 170                 175
Ser Val Leu Glu Thr Leu Thr Asp Val Ala His Glu Tyr Cys Leu Lys
            180                 185                 190
Phe Thr Lys Leu Leu Arg Phe Ala Val Asp Arg Glu Ala Arg Leu Gly
        195                 200                 205
Gln Thr Pro Phe Pro Asp Val Met Glu Gln Val Phe His Glu Val Gly
    210                 215                 220
Ile Gly Ser Val Leu Ser Leu Gln Lys Phe Trp Gln His Arg Ile Lys
225                 230                 235                 240
Asp Tyr His Ser Tyr Met Leu Gln Ile Ser Lys Gln Leu Ser Glu Glu
                245                 250                 255
Tyr Glu Arg Ile Val Asn Pro Glu Lys Ala Thr Glu Asp Ala Lys Pro
            260                 265                 270
Val Lys Ile Lys Glu Glu Pro Val Ser Asp Ile Thr Phe Pro Val Ser
        275                 280                 285
Glu Glu Leu Glu Ala Asp Leu Ala Ser Gly Asp Gln Ser Leu Pro Met
    290                 295                 300
Gly Val Leu Gly Ala Gln Ser Glu Arg Phe Pro Ser Asn Leu Glu Val
305                 310                 315                 320
Glu Ala Ser Pro Gln Ala Ser Ser Ala Glu Val Asn Ala Ser Pro Leu
                325                 330                 335
Trp Asn Leu Ala His Val Lys Met Glu Pro Gln Glu Ser Glu Glu Gly
            340                 345                 350
Asn Val Ser Gly His Gly Val Leu Gly Ser Asp Val Phe Glu Glu Pro
        355                 360                 365
Met Ser Gly Met Ser Glu Ala Gly Ile Pro Gln Ser Pro Asp Asp Ser
    370                 375                 380
Asp Ser Ser Tyr Gly Ser His Ser Thr Asp Ser Leu Met Gly Ser Ser
385                 390                 395                 400
Pro Val Phe Asn Gln Arg Cys Lys Lys Arg Met Arg Lys Ile
                405                 410

<210> 34
<211> 591
<212> PRT
<213> Homo sapiens

<400> 34
Met Val Pro Ser Ser Pro Ala Val Glu Lys Gln Val Pro Val Glu Pro
 1               5                  10                  15
Gly Pro Asp Pro Glu Leu Arg Ser Trp Arg His Leu Val Cys Tyr Leu
            20                  25                  30
Cys Phe Tyr Gly Phe Met Ala Gln Ile Arg Pro Gly Glu Ser Phe Ile
        35                  40                  45
Thr Pro Tyr Leu Leu Gly Pro Asp Lys Asn Phe Thr Arg Glu Gln Val
    50                  55                  60
Thr Asn Glu Ile Thr Pro Val Leu Ser Tyr Ser Tyr Leu Ala Val Leu
65                  70                  75                  80
Val Pro Val Phe Leu Leu Thr Asp Tyr Leu Arg Tyr Thr Pro Val Leu
                85                  90                  95
Leu Leu Gln Gly Leu Ser Phe Val Ser Val Trp Leu Leu Leu Leu Leu
            100                 105                 110
Gly His Ser Val Ala His Met Gln Leu Met Glu Leu Phe Tyr Ser Val
        115                 120                 125
Thr Met Ala Ala Arg Ile Ala Tyr Ser Ser Tyr Ile Phe Ser Leu Val
    130                 135                 140
Arg Pro Ala Arg Tyr Gln Arg Val Ala Gly Tyr Ser Arg Ala Ala Val
145                 150                 155                 160
Leu Leu Gly Val Phe Thr Ser Ser Val Leu Gly Gln Leu Leu Val Thr
                165                 170                 175
Val Gly Arg Val Ser Phe Ser Thr Leu Asn Tyr Ile Ser Leu Ala Phe
            180                 185                 190
Leu Thr Phe Ser Val Val Leu Ala Leu Phe Leu Lys Arg Pro Lys Arg
        195                 200                 205
Ser Leu Phe Phe Asn Arg Asp Asp Arg Gly Arg Cys Glu Thr Ser Ala
    210                 215                 220
Ser Glu Leu Glu Arg Met Asn Pro Gly Pro Gly Gly Lys Leu Gly His
225                 230                 235                 240
Ala Leu Arg Val Ala Cys Gly Asp Ser Val Leu Ala Arg Met Leu Arg
                245                 250                 255
Glu Leu Gly Asp Ser Leu Arg Arg Pro Gln Leu Arg Leu Trp Ser Leu
            260                 265                 270
Trp Trp Val Phe Asn Ser Ala Gly Tyr Tyr Leu Val Val Tyr Tyr Val
        275                 280                 285
His Ile Leu Trp Asn Glu Val Asp Pro Thr Thr Asn Ser Ala Arg Val
    290                 295                 300
Tyr Asn Gly Ala Ala Asp Ala Ala Ser Thr Leu Leu Gly Ala Ile Thr
305                 310                 315                 320
Ser Phe Ala Ala Gly Phe Val Lys Ile Arg Trp Ala Arg Trp Ser Lys
                325                 330                 335
Leu Leu Ile Ala Gly Val Thr Ala Thr Gln Ala Gly Leu Val Phe Leu
            340                 345                 350
Leu Ala His Thr Arg His Pro Ser Ser Ile Trp Leu Cys Tyr Ala Ala
        355                 360                 365
Phe Val Leu Phe Arg Gly Ser Tyr Gln Phe Leu Val Pro Ile Ala Thr
    370                 375                 380
Phe Gln Ile Ala Ser Ser Leu Ser Lys Glu Leu Cys Ala Leu Val Phe
385                 390                 395                 400
Gly Val Asn Thr Phe Phe Ala Thr Ile Val Lys Thr Ile Ile Thr Phe
                405                 410                 415
Ile Val Ser Asp Val Arg Gly Leu Gly Leu Pro Val Arg Lys Gln Phe
            420                 425                 430
Gln Leu Tyr Ser Val Tyr Phe Leu Ile Leu Ser Ile Ile Tyr Phe Leu
        435                 440                 445
Gly Ala Met Leu Asp Gly Leu Arg His Cys Gln Arg Gly His His Pro
    450                 455                 460
Arg Gln Pro Pro Ala Gln Gly Leu Arg Ser Ala Ala Glu Glu Lys Ala
465                 470                 475                 480
Ala Gln Ala Leu Ser Val Gln Asp Lys Gly Leu Gly Gly Leu Gln Pro
                485                 490                 495
Ala Gln Ser Pro Pro Leu Ser Pro Glu Asp Ser Leu Gly Ala Val Gly
            500                 505                 510
Pro Ala Ser Leu Glu Gln Arg Gln Ser Asp Pro Tyr Leu Ala Gln Ala
        515                 520                 525
Pro Ala Pro Gln Ala Ala Glu Phe Leu Ser Pro Val Thr Thr Pro Ser
    530                 535                 540
Pro Cys Thr Leu Cys Ser Ala Gln Ala Ser Gly Pro Glu Ala Ala Asp
545                 550                 555                 560
Glu Thr Cys Pro Gln Leu Ala Val His Pro Pro Gly Val Ser Lys Leu
                565                 570                 575
Gly Leu Gln Cys Leu Pro Ser Asp Gly Val Gln Asn Val Asn Gln
            580                 585                 590

<210> 35
<211> 526
<212> PRT
<213> Homo sapiens

<400> 35
Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser
 1               5                  10                  15
Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr
            20                  25                  30
Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser
        35                  40                  45
Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu
    50                  55                  60
Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr
65                  70                  75                  80
Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu
                85                  90                  95
Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His
            100                 105                 110
Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val
        115                 120                 125
Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg
    130                 135                 140
Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg
145                 150                 155                 160
Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn
                165                 170                 175
Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu
            180                 185                 190
Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr
        195                 200                 205
Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala
    210                 215                 220
Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe
225                 230                 235                 240
Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala
                245                 250                 255
Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly
            260                 265                 270
Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu
        275                 280                 285
Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu
    290                 295                 300
Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu
305                 310                 315                 320
Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro
                325                 330                 335
Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser
            340                 345                 350
Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg
        355                 360                 365
Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys
    370                 375                 380
Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg
385                 390                 395                 400
Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg
                405                 410                 415
Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser
            420                 425                 430
His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu
        435                 440                 445
Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly
    450                 455                 460
His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp
465                 470                 475                 480
His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg
                485                 490                 495
Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys
            500                 505                 510
His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg
        515                 520                 525

<210> 36
<211> 410
<212> PRT
<213> Homo sapiens

<400> 36
Met Glu Leu Pro Ser Gly Pro Gly Pro Glu Arg Leu Phe Asp Ser His
 1               5                  10                  15
Arg Leu Pro Gly Asp Cys Phe Leu Leu Leu Val Leu Leu Leu Tyr Ala
            20                  25                  30
Pro Val Gly Phe Cys Leu Leu Val Leu Arg Leu Phe Leu Gly Ile His
        35                  40                  45
Val Phe Leu Val Ser Cys Ala Leu Pro Asp Ser Val Leu Arg Arg Phe
    50                  55                  60
Val Val Arg Thr Met Cys Ala Val Leu Gly Leu Val Ala Arg Gln Glu
65                  70                  75                  80
Asp Ser Gly Leu Arg Asp His Ser Val Arg Val Leu Ile Ser Asn His
                85                  90                  95
Val Thr Pro Phe Asp His Asn Ile Val Asn Leu Leu Thr Thr Cys Ser
            100                 105                 110
Thr Pro Leu Leu Asn Ser Pro Pro Ser Phe Val Cys Trp Ser Arg Gly
        115                 120                 125
Phe Met Glu Met Asn Gly Arg Gly Glu Leu Val Glu Ser Leu Lys Arg
    130                 135                 140
Phe Cys Ala Ser Thr Arg Leu Pro Pro Thr Pro Leu Leu Leu Phe Pro
145                 150                 155                 160
Glu Glu Glu Ala Thr Asn Gly Arg Glu Gly Leu Leu Arg Phe Ser Ser
                165                 170                 175
Trp Pro Phe Ser Ile Gln Asp Val Val Gln Pro Leu Thr Leu Gln Val
            180                 185                 190
Gln Arg Pro Leu Val Ser Val Thr Val Ser Asp Ala Ser Trp Val Ser
        195                 200                 205
Glu Leu Leu Trp Ser Leu Phe Val Pro Phe Thr Val Tyr Gln Val Arg
    210                 215                 220
Trp Leu Arg Pro Val His Arg Gln Leu Gly Glu Ala Asn Glu Glu Phe
225                 230                 235                 240
Ala Leu Arg Val Gln Gln Leu Val Ala Lys Glu Leu Gly Gln Thr Gly
                245                 250                 255
Thr Arg Leu Thr Pro Ala Asp Lys Ala Glu His Met Lys Arg Gln Arg
            260                 265                 270
His Pro Arg Leu Arg Pro Gln Ser Ala Gln Ser Ser Phe Pro Pro Ser
        275                 280                 285
Pro Gly Pro Ser Pro Asp Val Gln Leu Ala Thr Leu Ala Gln Arg Val
    290                 295                 300
Lys Glu Val Leu Pro His Val Pro Leu Gly Val Ile Gln Arg Asp Leu
305                 310                 315                 320
Ala Lys Thr Gly Cys Val Asp Leu Thr Ile Thr Asn Leu Leu Glu Gly
                325                 330                 335
Ala Val Ala Phe Met Pro Glu Asp Ile Thr Lys Gly Thr Gln Ser Leu
            340                 345                 350
Pro Thr Ala Ser Ala Ser Lys Phe Pro Ser Ser Gly Pro Val Thr Pro
        355                 360                 365
Gln Pro Thr Ala Leu Thr Phe Ala Lys Ser Ser Trp Ala Arg Gln Glu
    370                 375                 380
Ser Leu Gln Glu Arg Lys Gln Ala Leu Tyr Glu Tyr Ala Arg Arg Arg
385                 390                 395                 400
Phe Thr Glu Arg Arg Ala Gln Glu Ala Asp
                405                 410

<210> 37
<211> 482
<212> PRT
<213> Homo sapiens

<400> 37
Met Ala Ala Pro Glu Lys Met Thr Phe Pro Glu Lys Pro Ser His Lys
 1               5                  10                  15
Lys Tyr Arg Ala Ala Leu Lys Lys Glu Lys Arg Lys Lys Arg Arg Gln
            20                  25                  30
Glu Leu Ala Arg Leu Arg Asp Ser Gly Leu Ser Gln Lys Glu Glu Glu
        35                  40                  45
Glu Asp Thr Phe Ile Glu Glu Gln Gln Leu Glu Glu Glu Lys Leu Leu
    50                  55                  60
Glu Arg Glu Arg Gln Arg Leu His Glu Glu Trp Leu Leu Arg Glu Gln
65                  70                  75                  80
Lys Ala Gln Glu Glu Phe Arg Ile Lys Lys Glu Lys Glu Glu Ala Ala
                85                  90                  95
Lys Lys Arg Gln Glu Glu Gln Glu Arg Lys Leu Lys Glu Gln Trp Glu
            100                 105                 110
Glu Gln Gln Arg Lys Glu Arg Glu Glu Glu Glu Gln Lys Arg Gln Glu
        115                 120                 125
Lys Lys Glu Lys Glu Glu Ala Leu Gln Lys Met Leu Asp Gln Ala Glu
    130                 135                 140
Asn Glu Leu Glu Asn Gly Thr Thr Trp Gln Asn Pro Glu Pro Pro Val
145                 150                 155                 160
Asp Phe Arg Val Met Glu Lys Asp Arg Ala Asn Cys Pro Phe Tyr Ser
                165                 170                 175
Lys Thr Gly Ala Cys Arg Phe Gly Asp Arg Cys Ser Arg Lys His Asn
            180                 185                 190
Phe Pro Thr Ser Ser Pro Thr Leu Leu Ile Lys Ser Met Phe Thr Thr
        195                 200                 205
Phe Gly Met Glu Gln Cys Arg Arg Asp Asp Tyr Asp Pro Asp Ala Ser
    210                 215                 220
Leu Glu Tyr Ser Glu Glu Glu Thr Tyr Gln Gln Phe Leu Asp Phe Tyr
225                 230                 235                 240
Glu Asp Val Leu Pro Glu Phe Lys Asn Val Gly Lys Val Ile Gln Phe
                245                 250                 255
Lys Val Ser Cys Asn Leu Glu Pro His Leu Arg Gly Asn Val Tyr Val
            260                 265                 270
Gln Tyr Gln Ser Glu Glu Glu Cys Gln Ala Ala Leu Ser Leu Phe Asn
        275                 280                 285
Gly Arg Trp Tyr Ala Gly Arg Gln Leu Gln Cys Glu Phe Cys Pro Val
    290                 295                 300
Thr Arg Trp Lys Met Ala Ile Cys Gly Leu Phe Glu Ile Gln Gln Cys
305                 310                 315                 320
Pro Arg Gly Lys His Cys Asn Phe Leu His Val Phe Arg Asn Pro Asn
                325                 330                 335
Asn Glu Phe Trp Glu Ala Asn Arg Asp Ile Tyr Leu Ser Pro Asp Arg
            340                 345                 350
Thr Gly Ser Ser Phe Gly Lys Asn Ser Glu Arg Arg Glu Arg Met Gly
        355                 360                 365
His His Asp Asp Tyr Tyr Ser Arg Leu Arg Gly Arg Arg Asn Pro Ser
    370                 375                 380
Pro Asp His Ser Tyr Lys Arg Asn Gly Glu Ser Glu Arg Lys Ser Ser
385                 390                 395                 400
Arg His Arg Gly Lys Lys Ser His Lys Arg Thr Ser Lys Ser Arg Glu
                405                 410                 415
Arg His Asn Ser Arg Ser Arg Gly Arg Asn Arg Asp Arg Ser Arg Asp
            420                 425                 430
Arg Ser Arg Gly Arg Gly Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg
        435                 440                 445
Arg Ser Arg Arg Ser Arg Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg
    450                 455                 460
Gly Arg Arg Arg Ser Gly Asn Arg Asp Arg Thr Val Gln Ser Pro Lys
465                 470                 475                 480
Ser Lys


<210> 38
<211> 1512
<212> PRT
<213> Homo sapiens

<400> 38
Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser
 1               5                  10                  15
Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu
            20                  25                  30
Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu
        35                  40                  45
Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro
    50                  55                  60
Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys
65                  70                  75                  80
Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys
                85                  90                  95
Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly
            100                 105                 110
Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln
        115                 120                 125
Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val
    130                 135                 140
Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly
145                 150                 155                 160
Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly
                165                 170                 175
Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu
            180                 185                 190
Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg
        195                 200                 205
Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly
    210                 215                 220
Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu
225                 230                 235                 240
Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly
                245                 250                 255
Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys
            260                 265                 270
Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu
        275                 280                 285
Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys
    290                 295                 300
Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly
305                 310                 315                 320
Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg
                325                 330                 335
Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser
            340                 345                 350
Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro
        355                 360                 365
Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro
    370                 375                 380
Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser
385                 390                 395                 400
Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser
                405                 410                 415
Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg
            420                 425                 430
Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser
        435                 440                 445
Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala
    450                 455                 460
Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala
465                 470                 475                 480
Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr
                485                 490                 495
Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val
            500                 505                 510
Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser
        515                 520                 525
Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln
    530                 535                 540
Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys
545                 550                 555                 560
Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu
                565                 570                 575
Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly
            580                 585                 590
Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro
        595                 600                 605
Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser
    610                 615                 620
Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys
625                 630                 635                 640
Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro
                645                 650                 655
Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr
            660                 665                 670
Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly
        675                 680                 685
Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys
    690                 695                 700
Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr
705                 710                 715                 720
Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val
                725                 730                 735
Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu
            740                 745                 750
Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys
        755                 760                 765
Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys
    770                 775                 780
Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly
785                 790                 795                 800
Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser
                805                 810                 815
Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn
            820                 825                 830
Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg
        835                 840                 845
Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser
    850                 855                 860
Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg
865                 870                 875                 880
Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp
                885                 890                 895
Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro
            900                 905                 910
Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg
        915                 920                 925
Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu
    930                 935                 940
Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu
945                 950                 955                 960
Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp
                965                 970                 975
Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala
            980                 985                 990
Leu Gln Cys Glu Phe Leu Arg Asp Val Glu Pro Ser Lys Met Pro Pro
        995                 1000                1005
Pro Asp Leu Pro Leu Trp Gln Asp Cys His Glu Leu Trp Ser Lys Lys
    1010                1015                1020
Arg Arg Arg Gln Lys Gln Met Gly Met Thr Asp Asp Val Ser Thr Ile
1025                1030                1035                1040
Lys Ala Pro Arg Lys Asp Leu Ser Leu Gly Leu Asp Asp Ser Arg Thr
                1045                1050                1055
Asn Thr Pro Gln Gly Val Leu Pro Ser Ser Gln Leu Lys Ser Gln Gly
            1060                1065                1070
Ser Ser Asn Val Ala Pro Val Lys Thr Gly Pro Gly Gln His Leu Asn
        1075                1080                1085
His Ser Glu Leu Ala Ile Leu Leu Asn Leu Leu Gln Ser Lys Thr Ser
    1090                1095                1100
Val Asn Met Ala Asp Phe Val Gln Val Leu Asn Ile Lys Val Asn Ser
1105                1110                1115                1120
Glu Thr Gln Gln Gln Leu Asn Lys Ile Asn Leu Pro Ala Gly Ile Leu
                1125                1130                1135
Ala Thr Gly Glu Lys Gln Thr Asp Pro Ser Thr Pro Gln Gln Glu Ser
            1140                1145                1150
Ser Lys Pro Leu Gly Gly Ile Gln Pro Ser Ser Gln Thr Ile Gln Pro
        1155                1160                1165
Lys Val Glu Thr Asp Ala Ala Gln Ala Ala Val Gln Ser Ala Phe Ala
    1170                1175                1180
Val Leu Leu Thr Gln Leu Ile Lys Ala Gln Gln Ser Lys Gln Lys Asp
1185                1190                1195                1200
Val Leu Leu Glu Glu Arg Glu Asn Gly Ser Gly His Glu Ala Ser Leu
                1205                1210                1215
Gln Leu Arg Pro Pro Pro Glu Pro Ser Thr Pro Val Ser Gly Gln Asp
            1220                1225                1230
Asp Leu Ile Gln His Gln Asp Met Arg Ile Leu Glu Leu Thr Pro Glu
        1235                1240                1245
Pro Asp Arg Pro Arg Ile Leu Pro Pro Asp Gln Arg Pro Pro Glu Pro
    1250                1255                1260
Pro Glu Pro Pro Pro Val Thr Glu Glu Asp Leu Asp Tyr Arg Thr Glu
1265                1270                1275                1280
Asn Gln His Val Pro Thr Thr Ser Ser Ser Leu Thr Asp Pro His Ala
                1285                1290                1295
Gly Val Lys Ala Ala Leu Leu Gln Leu Leu Ala Gln His Gln Pro Gln
            1300                1305                1310
Asp Asp Pro Lys Arg Glu Gly Gly Ile Asp Tyr Gln Ala Gly Asp Thr
        1315                1320                1325
Tyr Val Ser Thr Ser Asp Tyr Lys Asp Asn Phe Gly Ser Ser Ser Phe
    1330                1335                1340
Ser Ser Ala Pro Tyr Val Ser Asn Asp Gly Leu Gly Ser Ser Ser Ala
1345                1350                1355                1360
Pro Pro Leu Glu Arg Arg Ser Phe Ile Gly Asn Ser Asp Ile Gln Ser
                1365                1370                1375
Leu Asp Asn Tyr Ser Thr Ala Ser Ser His Ser Gly Gly Pro Pro Gln
            1380                1385                1390
Pro Ser Ala Phe Ser Glu Ser Phe Pro Ser Ser Val Ala Gly Tyr Gly
        1395                1400                1405
Asp Ile Tyr Leu Asn Ala Gly Pro Met Leu Phe Ser Gly Asp Lys Asp
    1410                1415                1420
His Arg Phe Glu Tyr Ser His Gly Pro Ile Ala Val Leu Ala Asn Ser
1425                1430                1435                1440
Ser Asp Pro Ser Thr Gly Pro Glu Ser Thr His Pro Leu Pro Ala Lys
                1445                1450                1455
Met His Asn Tyr Asn Tyr Gly Gly Asn Leu Gln Glu Asn Pro Ser Gly
            1460                1465                1470
Pro Ser Leu Met His Gly Gln Thr Trp Thr Ser Pro Ala Gln Gly Pro
        1475                1480                1485
Gly Tyr Ser Gln Gly Tyr Arg Gly His Ile Ser Thr Ser Thr Gly Arg
    1490                1495                1500
Gly Arg Gly Arg Gly Leu Pro Tyr
1505                1510

<210> 39
<211> 850
<212> PRT
<213> Homo sapiens

<400> 39
Met Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Ser Ser Glu Ala Pro
 1               5                  10                  15
Ala Ala Ser Ala Thr Ala Glu Pro Glu Ala Gly Asp Gln Asp Ser Arg
            20                  25                  30
Glu Val Arg Val Leu Gln Ser Leu Arg Gly Lys Ile Cys Glu Ala Lys
        35                  40                  45
Asn Leu Leu Pro Tyr Leu Gly Pro His Lys Met Arg Asp Cys Phe Cys
    50                  55                  60
Thr Ile Asn Leu Asp Gln Glu Glu Val Tyr Arg Thr Gln Val Val Glu
65                  70                  75                  80
Lys Ser Leu Ser Pro Phe Phe Ser Glu Glu Phe Tyr Phe Glu Ile Pro
                85                  90                  95
Arg Thr Phe Gln Tyr Leu Ser Phe Tyr Val Tyr Asp Lys Asn Val Leu
            100                 105                 110
Gln Arg Asp Leu Arg Ile Gly Lys Val Ala Ile Lys Lys Glu Asp Leu
        115                 120                 125
Cys Asn His Ser Gly Lys Glu Thr Trp Phe Ser Leu Gln Pro Val Asp
    130                 135                 140
Ser Asn Ser Glu Val Gln Gly Lys Val His Leu Glu Leu Lys Leu Asn
145                 150                 155                 160
Glu Leu Ile Thr Glu Asn Gly Thr Val Cys Gln Gln Leu Val Val His
                165                 170                 175
Ile Lys Ala Cys His Gly Leu Pro Leu Ile Asn Gly Gln Ser Cys Asp
            180                 185                 190
Pro Tyr Ala Thr Val Ser Leu Val Gly Pro Ser Arg Asn Asp Gln Lys
        195                 200                 205
Lys Thr Lys Val Lys Lys Lys Thr Ser Asn Pro Gln Phe Asn Glu Ile
    210                 215                 220
Phe Tyr Phe Glu Val Thr Arg Ser Ser Ser Tyr Thr Arg Lys Ser Gln
225                 230                 235                 240
Phe Gln Val Glu Glu Glu Asp Ile Glu Lys Leu Glu Ile Arg Ile Asp
                245                 250                 255
Leu Trp Asn Asn Gly Asn Leu Val Gln Asp Val Phe Leu Gly Glu Ile
            260                 265                 270
Lys Val Pro Val Asn Val Leu Arg Thr Asp Ser Ser His Gln Ala Trp
        275                 280                 285
Tyr Leu Leu Gln Pro Arg Asp Asn Gly Asn Lys Ser Ser Lys Thr Asp
    290                 295                 300
Asp Leu Gly Ser Leu Arg Leu Asn Ile Cys Tyr Thr Glu Asp Tyr Val
305                 310                 315                 320
Leu Pro Ser Glu Tyr Tyr Gly Pro Leu Lys Thr Leu Leu Leu Lys Ser
                325                 330                 335
Pro Asp Val Gln Pro Ile Ser Ala Ser Ala Ala Tyr Ile Leu Ser Glu
            340                 345                 350
Ile Cys Arg Asp Lys Asn Asp Ala Val Leu Pro Leu Val Arg Leu Leu
        355                 360                 365
Leu His His Asp Lys Leu Val Pro Phe Ala Thr Ala Val Ala Glu Leu
    370                 375                 380
Asp Leu Lys Asp Thr Gln Asp Ala Asn Thr Ile Phe Arg Gly Asn Ser
385                 390                 395                 400
Leu Ala Thr Arg Cys Leu Asp Glu Met Met Lys Ile Val Gly Gly His
                405                 410                 415
Tyr Leu Lys Val Thr Leu Lys Pro Ile Leu Asp Glu Ile Cys Asp Ser
            420                 425                 430
Ser Lys Ser Cys Glu Ile Asp Pro Ile Lys Leu Lys Glu Gly Asp Asn
        435                 440                 445
Val Glu Asn Asn Lys Glu Asn Leu Arg Tyr Tyr Val Asp Lys Leu Phe
    450                 455                 460
Asn Thr Ile Val Lys Ser Ser Met Ser Cys Pro Thr Val Met Cys Asp
465                 470                 475                 480
Ile Phe Tyr Ser Leu Arg Gln Met Ala Thr Gln Arg Phe Pro Asn Asp
                485                 490                 495
Pro His Val Gln Tyr Ser Ala Val Ser Ser Phe Val Phe Leu Arg Phe
            500                 505                 510
Phe Ala Val Ala Val Val Ser Pro His Thr Phe His Leu Arg Pro His
        515                 520                 525
His Pro Asp Ala Gln Thr Ile Arg Thr Leu Thr Leu Ile Ser Lys Thr
    530                 535                 540
Ile Gln Thr Leu Gly Ser Trp Gly Ser Leu Ser Lys Ser Lys Ser Ser
545                 550                 555                 560
Phe Lys Glu Thr Phe Met Cys Glu Phe Phe Lys Met Phe Gln Glu Glu
                565                 570                 575
Gly Tyr Ile Ile Ala Val Lys Lys Phe Leu Asp Glu Ile Ser Ser Thr
            580                 585                 590
Glu Thr Lys Glu Ser Ser Gly Thr Ser Glu Pro Val His Leu Lys Glu
        595                 600                 605
Gly Glu Met Tyr Lys Arg Ala Gln Gly Arg Thr Arg Ile Gly Lys Lys
    610                 615                 620
Asn Phe Lys Lys Arg Trp Phe Cys Leu Thr Ser Arg Glu Leu Thr Tyr
625                 630                 635                 640
His Lys Gln Pro Gly Ser Lys Asp Ala Ile Tyr Thr Ile Pro Val Lys
                645                 650                 655
Asn Ile Leu Ala Val Glu Lys Leu Glu Glu Ser Ser Phe Asn Lys Lys
            660                 665                 670
Asn Met Phe Gln Val Ile His Thr Glu Lys Pro Leu Tyr Val Gln Ala
        675                 680                 685
Asn Asn Cys Val Glu Ala Asn Glu Trp Ile Asp Val Leu Cys Arg Val
    690                 695                 700
Ser Arg Cys Asn Gln Asn Arg Leu Ser Phe Tyr His Pro Ser Val Tyr
705                 710                 715                 720
Leu Asn Gly Asn Trp Leu Cys Cys Gln Glu Thr Gly Glu Asn Thr Leu
                725                 730                 735
Gly Cys Lys Pro Cys Thr Ala Gly Val Pro Ala Asp Ile Gln Ile Asp
            740                 745                 750
Ile Asp Glu Asp Arg Glu Thr Glu Arg Ile Tyr Ser Leu Phe Thr Leu
        755                 760                 765
Ser Leu Leu Lys Leu Gln Lys Met Glu Glu Ala Cys Gly Thr Ile Ala
    770                 775                 780
Val Tyr Gln Gly Pro Gln Lys Glu Pro Asp Asp Tyr Ser Asn Phe Val
785                 790                 795                 800
Ile Glu Asp Ser Val Thr Thr Phe Lys Thr Ile Gln Gln Ile Lys Ser
                805                 810                 815
Ile Ile Glu Lys Leu Asp Glu Pro His Glu Lys Tyr Arg Lys Lys Arg
            820                 825                 830
Ser Ser Ser Ala Lys Tyr Gly Ser Lys Glu Asn Pro Ile Val Gly Lys
        835                 840                 845
Ala Ser
    850

<210> 40
<211> 548
<212> PRT
<213> Homo sapiens

<400> 40
Met Lys Thr Pro Ala Asp Thr Gly Phe Ala Phe Pro Asp Trp Ala Tyr
 1               5                  10                  15
Lys Pro Glu Ser Ser Pro Gly Ser Arg Gln Ile Gln Leu Trp His Phe
            20                  25                  30
Ile Leu Glu Leu Leu Arg Lys Glu Glu Tyr Gln Gly Val Ile Ala Trp
        35                  40                  45
Gln Gly Asp Tyr Gly Glu Phe Val Ile Lys Asp Pro Asp Glu Val Ala
    50                  55                  60
Arg Leu Trp Gly Val Arg Lys Cys Lys Pro Gln Met Asn Tyr Asp Lys
65                  70                  75                  80
Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asn Lys Arg Ile Leu His Lys
                85                  90                  95
Thr Lys Gly Lys Arg Phe Thr Tyr Lys Phe Asn Phe Asn Lys Leu Val
            100                 105                 110
Leu Val Asn Tyr Pro Phe Ile Asp Val Gly Leu Ala Gly Gly Ala Val
        115                 120                 125
Pro Gln Ser Ala Pro Pro Val Pro Ser Gly Gly Ser His Phe Arg Phe
    130                 135                 140
Pro Pro Ser Thr Pro Ser Glu Val Leu Ser Pro Thr Glu Asp Pro Arg
145                 150                 155                 160
Ser Pro Pro Ala Cys Ser Ser Ser Ser Ser Ser Leu Phe Ser Ala Val
                165                 170                 175
Val Ala Arg Arg Leu Gly Arg Gly Ser Val Ser Asp Cys Ser Asp Gly
            180                 185                 190
Thr Ser Glu Leu Glu Glu Pro Leu Gly Glu Asp Pro Arg Ala Arg Pro
        195                 200                 205
Pro Gly Pro Pro Asp Leu Gly Ala Phe Arg Gly Pro Pro Leu Ala Arg
    210                 215                 220
Leu Pro His Asp Pro Gly Val Phe Arg Val Tyr Pro Arg Pro Arg Gly
225                 230                 235                 240
Gly Pro Glu Pro Leu Ser Pro Phe Pro Val Ser Pro Leu Ala Gly Pro
                245                 250                 255
Gly Ser Leu Leu Pro Pro Gln Leu Ser Pro Ala Leu Pro Met Thr Pro
            260                 265                 270
Thr His Leu Ala Tyr Thr Pro Ser Pro Thr Leu Ser Pro Met Tyr Pro
        275                 280                 285
Ser Gly Gly Gly Gly Pro Ser Gly Ser Gly Gly Gly Ser His Phe Ser
    290                 295                 300
Phe Ser Pro Glu Asp Met Lys Arg Tyr Leu Gln Ala His Thr Gln Ser
305                 310                 315                 320
Val Tyr Asn Tyr His Leu Ser Pro Arg Ala Phe Leu His Tyr Pro Gly
                325                 330                 335
Leu Val Val Pro Gln Pro Gln Arg Pro Asp Lys Cys Pro Leu Pro Pro
            340                 345                 350
Met Ala Pro Glu Thr Pro Pro Val Pro Ser Ser Ala Ser Ser Ser Ser
        355                 360                 365
Ser Ser Ser Ser Ser Pro Phe Lys Phe Lys Leu Gln Pro Pro Pro Leu
    370                 375                 380
Gly Arg Arg Gln Arg Ala Ala Gly Glu Lys Ala Val Ala Gly Ala Asp
385                 390                 395                 400
Lys Ser Gly Gly Ser Ala Gly Gly Leu Ala Glu Gly Ala Gly Ala Leu
                405                 410                 415
Ala Pro Pro Pro Pro Pro Pro Gln Ile Lys Val Glu Pro Ile Ser Glu
            420                 425                 430
Gly Glu Ser Glu Glu Val Glu Val Thr Asp Ile Ser Asp Glu Asp Glu
        435                 440                 445
Glu Asp Gly Glu Val Phe Lys Thr Pro Arg Ala Pro Pro Ala Pro Pro
    450                 455                 460
Lys Pro Glu Pro Gly Glu Ala Pro Gly Ala Ser Gln Cys Met Pro Leu
465                 470                 475                 480
Lys Leu Arg Phe Lys Arg Arg Trp Ser Glu Asp Cys Arg Leu Glu Gly
                485                 490                 495
Gly Gly Gly Pro Ala Gly Gly Phe Glu Asp Glu Gly Glu Asp Lys Lys
            500                 505                 510
Val Arg Gly Glu Gly Pro Gly Glu Ala Gly Gly Pro Leu Thr Pro Arg
        515                 520                 525
Arg Val Ser Ser Asp Leu Gln His Ala Thr Ala Gln Leu Ser Leu Glu
    530                 535                 540
His Arg Asp Ser
545

<210> 41
<211> 985
<212> PRT
<213> Homo sapiens

<400> 41
Met Asp Arg Arg Ser Met Gly Glu Thr Glu Ser Gly Asp Ala Phe Leu
 1               5                  10                  15
Asp Leu Lys Lys Pro Pro Ala Ser Lys Cys Pro His Arg Tyr Thr Lys
            20                  25                  30
Glu Glu Leu Leu Asp Ile Lys Glu Leu Pro His Ser Lys Gln Arg Pro
        35                  40                  45
Ser Cys Leu Ser Glu Lys Tyr Asp Ser Asp Gly Val Trp Asp Pro Glu
    50                  55                  60
Lys Trp His Ala Ser Leu Tyr Pro Ala Ser Gly Arg Ser Ser Pro Val
65                  70                  75                  80
Glu Ser Leu Lys Lys Glu Leu Asp Thr Asp Arg Pro Ser Leu Val Arg
                85                  90                  95
Arg Ile Val Asp Pro Arg Glu Arg Val Lys Glu Asp Asp Leu Asp Val
            100                 105                 110
Val Leu Ser Pro Gln Arg Arg Ser Phe Gly Gly Gly Cys His Val Thr
        115                 120                 125
Ala Ala Val Ser Ser Arg Arg Ser Gly Ser Pro Leu Glu Lys Asp Ser
    130                 135                 140
Asp Gly Leu Arg Leu Leu Gly Gly Arg Arg Ile Gly Ser Gly Arg Ile
145                 150                 155                 160
Ile Ser Ala Arg Thr Phe Glu Lys Asp His Arg Leu Ser Asp Lys Asp
                165                 170                 175
Leu Arg Asp Leu Arg Asp Arg Asp Arg Glu Arg Asp Phe Lys Asp Lys
            180                 185                 190
Arg Phe Arg Arg Glu Phe Gly Asp Ser Lys Arg Val Phe Gly Glu Arg
        195                 200                 205
Arg Arg Asn Asp Ser Tyr Thr Glu Glu Glu Pro Glu Trp Phe Ser Ala
    210                 215                 220
Gly Pro Thr Ser Gln Ser Glu Thr Ile Glu Leu Thr Gly Phe Asp Asp
225                 230                 235                 240
Lys Ile Leu Glu Glu Asp His Lys Gly Arg Lys Arg Thr Arg Arg Arg
                245                 250                 255
Thr Ala Ser Val Lys Glu Gly Ile Val Glu Cys Asn Gly Gly Val Ala
            260                 265                 270
Glu Glu Asp Glu Val Glu Val Ile Leu Ala Gln Glu Pro Ala Ala Asp
        275                 280                 285
Gln Glu Val Pro Arg Asp Ala Val Leu Pro Glu Gln Ser Pro Gly Asp
    290                 295                 300
Phe Asp Phe Asn Glu Phe Phe Asn Leu Asp Lys Val Pro Cys Leu Ala
305                 310                 315                 320
Ser Met Ile Glu Asp Val Leu Gly Glu Gly Ser Val Ser Ala Ser Arg
                325                 330                 335
Phe Ser Arg Trp Phe Ser Asn Pro Ser Arg Ser Gly Ser Arg Ser Ser
            340                 345                 350
Ser Leu Gly Ser Thr Pro His Glu Glu Leu Glu Arg Leu Ala Gly Leu
        355                 360                 365
Glu Gln Ala Ile Leu Ser Pro Gly Gln Asn Ser Gly Asn Tyr Phe Ala
    370                 375                 380
Pro Ile Pro Leu Glu Asp His Ala Glu Asn Lys Val Asp Ile Leu Glu
385                 390                 395                 400
Met Leu Gln Lys Ala Lys Val Asp Leu Lys Pro Leu Leu Ser Ser Leu
                405                 410                 415
Ser Ala Asn Lys Glu Lys Leu Lys Glu Ser Ser His Ser Gly Val Val
            420                 425                 430
Leu Ser Val Glu Glu Val Glu Ala Gly Leu Lys Gly Leu Lys Val Asp
        435                 440                 445
Gln Gln Val Lys Asn Ser Thr Pro Phe Met Ala Glu His Leu Glu Glu
    450                 455                 460
Thr Leu Ser Ala Val Thr Asn Asn Arg Gln Leu Lys Lys Asp Gly Asp
465                 470                 475                 480
Met Thr Ala Phe Asn Lys Leu Val Ser Thr Met Lys Ala Ser Gly Thr
                485                 490                 495
Leu Pro Ser Gln Pro Lys Val Ser Arg Asn Leu Glu Ser His Leu Met
            500                 505                 510
Ser Pro Ala Glu Ile Pro Gly Gln Pro Val Pro Lys Asn Ile Leu Gln
        515                 520                 525
Glu Leu Leu Gly Gln Pro Val Gln Arg Pro Ala Ser Ser Asn Leu Leu
    530                 535                 540
Ser Gly Leu Met Gly Ser Leu Glu Pro Thr Thr Ser Leu Leu Gly Gln
545                 550                 555                 560
Arg Ala Pro Ser Pro Pro Leu Ser Gln Val Phe Gln Thr Arg Ala Ala
                565                 570                 575
Ser Ala Asp Tyr Leu Arg Pro Arg Ile Pro Ser Pro Ile Gly Phe Thr
            580                 585                 590
Pro Gly Pro Gln Gln Leu Leu Gly Asp Pro Phe Gln Gly Met Arg Lys
        595                 600                 605
Pro Met Ser Pro Ile Thr Ala Gln Met Ser Gln Leu Glu Leu Gln Gln
    610                 615                 620
Ala Ala Leu Glu Gly Leu Ala Leu Pro His Asp Leu Ala Val Gln Ala
625                 630                 635                 640
Ala Asn Phe Tyr Gln Pro Gly Phe Gly Lys Pro Gln Val Asp Arg Thr
                645                 650                 655
Arg Asp Gly Phe Arg Asn Arg Gln Gln Arg Val Thr Lys Ser Pro Ala
            660                 665                 670
Pro Val His Arg Gly Asn Ser Ser Ser Pro Ala Pro Ala Ala Ser Ile
        675                 680                 685
Thr Ser Met Leu Ser Pro Ser Phe Thr Pro Thr Ser Val Ile Arg Lys
    690                 695                 700
Met Tyr Glu Ser Lys Glu Lys Ser Lys Glu Glu Pro Ala Ser Gly Lys
705                 710                 715                 720
Ala Ala Leu Gly Asp Ser Lys Glu Asp Thr Gln Lys Ala Ser Glu Glu
                725                 730                 735
Asn Leu Leu Ser Ser Ser Ser Val Pro Ser Ala Asp Arg Asp Ser Ser
            740                 745                 750
Pro Thr Thr Asn Ser Lys Leu Ser Ala Leu Gln Arg Ser Ser Cys Ser
        755                 760                 765
Thr Pro Leu Ser Gln Ala Asn Arg Tyr Thr Lys Glu Gln Asp Tyr Arg
    770                 775                 780
Pro Lys Ala Thr Gly Arg Lys Thr Pro Thr Leu Ala Ser Pro Val Pro
785                 790                 795                 800
Thr Thr Pro Phe Leu Arg Pro Val His Gln Val Pro Leu Val Pro His
                805                 810                 815
Val Pro Met Val Arg Pro Ala His Gln Leu His Pro Gly Leu Val Gln
            820                 825                 830
Arg Met Leu Ala Gln Gly Val His Pro Gln His Leu Pro Ser Leu Leu
        835                 840                 845
Gln Thr Gly Val Leu Pro Pro Gly Met Asp Leu Ser His Leu Gln Gly
    850                 855                 860
Ile Ser Gly Pro Ile Leu Gly Gln Pro Phe Tyr Pro Leu Pro Ala Ala
865                 870                 875                 880
Ser His Pro Leu Leu Asn Pro Arg Pro Gly Thr Pro Leu His Leu Ala
                885                 890                 895
Met Val Gln Gln Gln Leu Gln Arg Ser Val Leu His Pro Pro Gly Ser
            900                 905                 910
Gly Ser His Ala Ala Ala Val Ser Val Gln Thr Thr Pro Gln Asn Val
        915                 920                 925
Pro Ser Arg Ser Gly Leu Pro His Met His Ser Gln Leu Glu His Arg
    930                 935                 940
Pro Ser Gln Arg Ser Ser Ser Pro Val Gly Leu Ala Lys Trp Phe Gly
945                 950                 955                 960
Ser Asp Val Leu Gln Gln Pro Leu Pro Ser Met Pro Ala Lys Val Ile
                965                 970                 975
Ser Val Asp Glu Leu Glu Tyr Arg Gln
            980                 985

<210> 42
<211> 692
<212> PRT
<213> Homo sapiens

<400> 42
Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu
 1               5                  10                  15
Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg
            20                  25                  30
Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Asn Val Lys Tyr
        35                  40                  45
Tyr Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys Asp Arg Gly Gln
    50                  55                  60
Lys Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly Leu Leu Ser Met
65                  70                  75                  80
Met Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala Ile Glu Val Phe
                85                  90                  95
Lys Pro Met Ala Asp Ala Ala Val Lys Ile Val Glu Lys Asn Gly Phe
            100                 105                 110
Ser Asp Lys Ile Lys Val Ile Asn Lys His Ser Thr Glu Val Thr Val
        115                 120                 125
Gly Pro Glu Gly Asp Met Pro Cys Arg Ala Asn Ile Leu Val Thr Glu
    130                 135                 140
Leu Phe Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu Pro Ser Tyr Glu
145                 150                 155                 160
His Ala His Arg His Leu Val Glu Glu Asn Cys Glu Ala Val Pro His
                165                 170                 175
Arg Ala Thr Val Tyr Ala Gln Leu Val Glu Ser Gly Arg Met Trp Ser
            180                 185                 190
Trp Asn Lys Leu Phe Pro Ile His Val Gln Thr Ser Leu Gly Glu Gln
        195                 200                 205
Val Ile Val Pro Pro Val Asp Val Glu Ser Cys Pro Gly Ala Pro Ser
    210                 215                 220
Val Cys Asp Ile Gln Leu Asn Gln Val Ser Pro Ala Asp Phe Thr Val
225                 230                 235                 240
Leu Ser Asp Val Leu Pro Met Phe Ser Ile Asp Phe Ser Lys Gln Val
                245                 250                 255
Ser Ser Ser Ala Ala Cys His Ser Arg Arg Phe Glu Pro Leu Thr Ser
            260                 265                 270
Gly Arg Ala Gln Val Val Leu Ser Trp Trp Asp Ile Glu Met Asp Pro
        275                 280                 285
Glu Gly Lys Ile Lys Cys Thr Met Ala Pro Phe Trp Ala His Ser Asp
    290                 295                 300
Pro Glu Glu Met Gln Trp Arg Asp His Trp Met Gln Cys Val Tyr Phe
305                 310                 315                 320
Leu Pro Gln Glu Glu Pro Val Val Gln Gly Ser Ala Leu Tyr Leu Val
                325                 330                 335
Ala His His Asp Asp Tyr Cys Val Trp Tyr Ser Leu Gln Arg Thr Ser
            340                 345                 350
Pro Glu Lys Asn Glu Arg Val Arg Gln Met Arg Pro Val Cys Asp Cys
        355                 360                 365
Gln Ala His Leu Leu Trp Asn Arg Pro Arg Phe Gly Glu Ile Asn Asp
    370                 375                 380
Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg Thr Val Leu Lys
385                 390                 395                 400
Pro Asp Ser Val Cys Leu Cys Val Ser Asp Gly Ser Leu Leu Ser Val
                405                 410                 415
Leu Ala His His Leu Gly Val Glu Gln Val Phe Thr Val Glu Ser Ser
            420                 425                 430
Ala Ala Ser His Lys Leu Leu Arg Lys Ile Phe Lys Ala Asn His Leu
        435                 440                 445
Glu Asp Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu Leu Leu Thr Asn
    450                 455                 460
Glu Asp Leu Gln Gly Arg Lys Val Ser Leu Leu Leu Gly Glu Pro Phe
465                 470                 475                 480
Phe Thr Thr Ser Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val
                485                 490                 495
Arg Thr Ala Val Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro
            500                 505                 510
Gln Ala Ala Ser Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp
        515                 520                 525
Arg Ile Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile
    530                 535                 540
Met Asp Asp Met Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu
545                 550                 555                 560
Ala Glu Pro His Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu
                565                 570                 575
Pro Trp Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln
            580                 585                 590
Pro Leu Cys Ala Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser
        595                 600                 605
His Ala Ala Val Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr
    610                 615                 620
Leu Ser Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys
625                 630                 635                 640
Trp Asn Pro His Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro
                645                 650                 655
Asp Pro Arg Ala Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val
            660                 665                 670
Glu Phe His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala
        675                 680                 685
Asp Thr Pro Asp
    690

<210> 43
<211> 692
<212> PRT
<213> Homo sapiens

<400> 43
Met Lys Ile Phe Cys Ser Arg Ala Asn Pro Thr Thr Gly Ser Val Glu
 1               5                  10                  15
Trp Leu Glu Glu Asp Glu His Tyr Asp Tyr His Gln Glu Ile Ala Arg
            20                  25                  30
Ser Ser Tyr Ala Asp Met Leu His Asp Lys Asp Arg Asn Val Lys Tyr
        35                  40                  45
Tyr Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys Asp Arg Gly Gln
    50                  55                  60
Lys Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly Leu Leu Ser Met
65                  70                  75                  80
Met Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala Ile Glu Val Phe
                85                  90                  95
Lys Pro Met Ala Asp Ala Ala Val Lys Ile Val Glu Lys Asn Gly Phe
            100                 105                 110
Ser Asp Lys Ile Lys Val Ile Asn Lys His Ser Thr Glu Val Thr Val
        115                 120                 125
Gly Pro Glu Gly Asp Met Pro Cys Arg Ala Asn Ile Leu Val Thr Glu
    130                 135                 140
Leu Phe Asp Thr Glu Leu Ile Gly Glu Gly Ala Leu Pro Ser Tyr Glu
145                 150                 155                 160
His Ala His Arg His Leu Val Glu Glu Asn Cys Glu Ala Val Pro His
                165                 170                 175
Arg Ala Thr Val Tyr Ala Gln Leu Val Glu Ser Gly Arg Met Trp Ser
            180                 185                 190
Trp Asn Lys Leu Phe Pro Ile His Val Gln Thr Ser Leu Gly Glu Gln
        195                 200                 205
Val Ile Val Pro Pro Val Asp Val Glu Ser Cys Pro Gly Ala Pro Ser
    210                 215                 220
Val Cys Asp Ile Gln Leu Asn Gln Val Ser Pro Ala Asp Phe Thr Val
225                 230                 235                 240
Leu Ser Asp Val Leu Pro Met Phe Ser Ile Asp Phe Ser Lys Gln Val
                245                 250                 255
Ser Ser Ser Ala Ala Cys His Ser Arg Arg Phe Glu Pro Leu Thr Ser
            260                 265                 270
Gly Arg Ala Gln Val Val Leu Ser Trp Trp Asp Ile Glu Met Asp Pro
        275                 280                 285
Glu Gly Lys Ile Lys Cys Thr Met Ala Pro Phe Trp Ala His Ser Asp
    290                 295                 300
Pro Glu Glu Met Gln Trp Arg Asp His Trp Met Gln Cys Val Tyr Phe
305                 310                 315                 320
Leu Pro Gln Glu Glu Pro Val Val Gln Gly Ser Ala Leu Tyr Leu Val
                325                 330                 335
Ala His His Asp Asp Tyr Cys Val Trp Tyr Ser Leu Gln Arg Thr Ser
            340                 345                 350
Pro Glu Lys Asn Glu Arg Val Arg Gln Met Arg Pro Val Cys Asp Cys
        355                 360                 365
Gln Ala His Leu Leu Trp Asn Arg Pro Arg Phe Gly Glu Ile Asn Asp
    370                 375                 380
Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala Leu Arg Thr Val Leu Lys
385                 390                 395                 400
Pro Asp Ser Val Cys Leu Cys Val Ser Asp Gly Ser Leu Leu Ser Val
                405                 410                 415
Leu Ala His His Leu Gly Val Glu Gln Val Phe Thr Val Glu Ser Ser
            420                 425                 430
Ala Ala Ser His Lys Leu Leu Arg Lys Ile Phe Lys Ala Asn His Leu
        435                 440                 445
Glu Asp Lys Ile Asn Ile Ile Glu Lys Arg Pro Glu Leu Leu Thr Asn
    450                 455                 460
Glu Asp Leu Gln Gly Arg Lys Val Ser Leu Leu Leu Gly Glu Pro Phe
465                 470                 475                 480
Phe Thr Thr Ser Leu Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val
                485                 490                 495
Arg Thr Ala Val Asp Gln His Leu Gly Pro Gly Ala Met Val Met Pro
            500                 505                 510
Gln Ala Ala Ser Leu His Ala Val Val Val Glu Phe Arg Asp Leu Trp
        515                 520                 525
Arg Ile Arg Ser Pro Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile
    530                 535                 540
Met Asp Asp Met Ile Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu
545                 550                 555                 560
Ala Glu Pro His Pro Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu
                565                 570                 575
Pro Trp Gln Ile Leu Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln
            580                 585                 590
Pro Leu Cys Ala Glu Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser
        595                 600                 605
His Ala Ala Val Leu Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr
    610                 615                 620
Leu Ser Thr Gly Leu Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys
625                 630                 635                 640
Trp Asn Pro His Cys Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro
                645                 650                 655
Asp Pro Arg Ala Leu Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val
            660                 665                 670
Glu Phe His Pro Asp Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala
        675                 680                 685
Asp Thr Pro Asp
    690

<210> 44
<211> 235
<212> PRT
<213> Homo sapiens

<400> 44
Met Trp Arg Gly Arg Ala Gly Ala Leu Leu Arg Val Trp Gly Phe Trp
 1               5                  10                  15
Pro Thr Gly Val Pro Arg Arg Arg Pro Leu Ser Cys Asp Ala Ala Ser
            20                  25                  30
Gln Ala Gly Ser Asn Tyr Pro Arg Cys Trp Asn Cys Gly Gly Pro Trp
        35                  40                  45
Gly Pro Gly Arg Glu Asp Arg Phe Phe Cys Pro Gln Cys Arg Ala Leu
    50                  55                  60
Gln Ala Pro Asp Pro Thr Arg Asp Tyr Phe Ser Leu Met Asp Cys Asn
65                  70                  75                  80
Arg Ser Phe Arg Val Asp Thr Ala Lys Leu Gln His Arg Tyr Gln Gln
                85                  90                  95
Leu Gln Arg Leu Val His Pro Asp Phe Phe Ser Gln Arg Ser Gln Thr
            100                 105                 110
Glu Lys Asp Phe Ser Glu Lys His Ser Thr Leu Val Asn Asp Ala Tyr
        115                 120                 125
Lys Thr Leu Leu Ala Pro Leu Ser Arg Gly Leu Tyr Leu Leu Lys Leu
    130                 135                 140
His Gly Ile Glu Ile Pro Glu Arg Thr Asp Tyr Glu Met Asp Arg Gln
145                 150                 155                 160
Phe Leu Ile Glu Ile Met Glu Ile Asn Glu Lys Leu Ala Glu Ala Glu
                165                 170                 175
Ser Glu Ala Ala Met Lys Glu Ile Glu Ser Ile Val Lys Ala Lys Gln
            180                 185                 190
Lys Glu Phe Thr Asp Asn Val Ser Ser Ala Phe Glu Gln Asp Asp Phe
        195                 200                 205
Glu Glu Ala Lys Glu Ile Leu Thr Lys Met Arg Tyr Phe Ser Asn Ile
    210                 215                 220
Glu Glu Lys Ile Lys Leu Lys Lys Ile Pro Leu
225                 230                 235

<210> 45
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 45
Met Ala Ser Cys Ala Ser Ile Asp Ile Glu Asp Ala Thr Gln His Leu
 1               5                  10                  15
Arg Asp Ile Leu Lys Leu Asp Arg Pro Ala Gly Gly Pro Ser Ala Glu
            20                  25                  30
Ser Pro Arg Pro Ser Ser Ala Tyr Asn Gly Asp Leu Asn Gly Leu Leu
        35                  40                  45
Val Pro Asp Pro Leu Cys Ser Gly Asp Ser Thr Ser Ala Asn Lys Thr
    50                  55                  60
Gly Leu Arg Thr Met Pro Pro Ile Asn Leu Gln Glu Lys Gln Val Ile
65                  70                  75                  80
Cys Leu Ser Gly Asp Asp Ser Ser Thr Cys Ile Gly Ile Leu Ala Lys
                85                  90                  95
Glu Val Glu Ile Val Ala Ser Ser Asp Ser Ser Ile Ser Ser Lys Ala
            100                 105                 110
Arg Gly Ser Asn Lys Val Lys Ile Gln Pro Val Ala Lys Tyr Asp Trp
        115                 120                 125
Glu Gln Lys Tyr Tyr Tyr Gly Asn Leu Ile Ala Val Ser Asn Ser Phe
    130                 135                 140
Leu Ala Tyr Ala Ile Arg Ala Ala Asn Asn Gly Ser Ala Met Val Arg
145                 150                 155                 160
Val Ile Ser Val Ser Thr Ser Glu Arg Thr Leu Leu Lys Gly Phe Thr
                165                 170                 175
Gly Ser Val Ala Asp Leu Ala Phe Ala His Leu Asn Ser Pro Gln Leu
            180                 185                 190
Ala Cys Leu Asp Glu Ala Gly Asn Leu Phe Val Trp Arg Leu Ala Leu
        195                 200                 205
Val Asn Gly Lys Ile Gln Glu Glu Ile Leu Val His Ile Arg Gln Pro
    210                 215                 220
Glu Gly Thr Pro Leu Asn His Phe Arg Arg Ile Ile Trp Cys Pro Phe
225                 230                 235                 240
Ile Pro Glu Glu Ser Glu Asp Cys Cys Glu Glu Ser Ser Pro Thr Val
                245                 250                 255
Ala Leu Leu His Glu Asp Arg Ala Glu Val Trp Asp Leu Asp Met Leu
            260                 265                 270
Arg Ser Ser His Ser Thr Trp Pro Val Asp Val Ser Gln Ile Lys Gln
        275                 280                 285
Gly Phe Ile Val Val Lys Gly His Ser Thr Cys Leu Ser Glu Gly Ala
    290                 295                 300
Leu Ser Pro Asp Gly Thr Val Leu Ala Thr Ala Ser His Asp Gly Tyr
305                 310                 315                 320
Val Lys Phe Trp Gln Ile Tyr Ile Glu Gly Gln Asp Glu Pro Arg Cys
                325                 330                 335
Leu His Glu Trp Lys Pro His Asp Gly Arg Pro Leu Ser Cys Leu Leu
            340                 345                 350
Phe Cys Asp Asn His Lys Lys Gln Asp Pro Asp Val Pro Phe Trp Arg
        355                 360                 365
Phe Leu Ile Thr Gly Ala Asp Gln Asn Arg Glu Leu Lys Met Trp Cys
    370                 375                 380
Thr Val Ser Trp Thr Cys Leu Gln Thr Ile Arg Phe Ser Pro Asp Ile
385                 390                 395                 400
Phe Ser Ser Val Ser Val Pro Pro Ser Leu Lys Val Cys Leu Asp Leu
                405                 410                 415
Ser Ala Glu Tyr Leu Ile Leu Ser Asp Val Gln Arg Lys Val Leu Tyr
            420                 425                 430
Val Met Glu Leu Leu Gln Asn Gln Glu Glu Gly His Ala Cys Phe Ser
        435                 440                 445
Ser Ile Ser Glu Phe Leu Leu Thr His Pro Val Leu Ser Phe Gly Ile
    450                 455                 460
Gln Val Val Ser Arg Cys Arg Leu Arg His Thr Glu Val Leu Pro Ala
465                 470                 475                 480
Glu Glu Glu Asn Asp Ser Leu Gly Ala Asp Gly Thr His Gly Ala Gly
                485                 490                 495
Ala Met Glu Ser Ala Ala Gly Val Leu Ile Lys Leu Phe Cys Val His
            500                 505                 510
Thr Lys Ala Leu Gln Asp Val Gln Ile Arg Phe Gln Pro Gln Leu Asn
        515                 520                 525
Pro Asp Val Val Ala Pro Leu Pro Thr His Thr Ala His Glu Asp Phe
    530                 535                 540
Thr Phe Gly Glu Ser Arg Pro Glu Leu Gly Ser Glu Gly Leu Gly Ser
545                 550                 555                 560
Ala Ala His Gly Ser Gln Pro Asp Leu Arg Arg Ile Val Glu Leu Pro
                565                 570                 575
Ala Pro Ala Asp Phe Leu Ser Leu Ser Ser Glu Thr Lys Pro Lys Leu
            580                 585                 590
Met Thr Pro Asp Ala Phe Met Thr Pro Ser Ala Ser Leu Gln Gln Ile
        595                 600                 605
Thr Ala Ser Pro Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser
    610                 615                 620
Ser Ser Ser Ser Ser Leu Thr Ala Val Ser Ala Met Ser Ser Thr Ser
625                 630                 635                 640
Ala Val Asp Pro Ser Leu Thr Arg Pro Pro Glu Glu Leu Thr Leu Ser
                645                 650                 655
Pro Lys Leu Gln Leu Asp Gly Ser Leu Thr Met Ser Ser Ser Gly Ser
            660                 665                 670
Leu Gln Ala Ser Pro Arg Gly Leu Leu Pro Gly Leu Leu Pro Ala Pro
        675                 680                 685
Ala Asp Lys Leu Thr Pro Lys Gly Pro Gly Gln Val Pro Thr Ala Thr
    690                 695                 700
Ser Ala Leu Ser Leu Glu Leu Gln Glu Val Glu Pro Leu Gly Leu Pro
705                 710                 715                 720
Gln Ala Ser Pro Ser Arg Thr Arg Ser Pro Asp Val Ile Ser Ser Ala
                725                 730                 735
Ser Thr Ala Leu Ser Gln Asp Ile Pro Glu Ile Ala Ser Glu Ala Leu
            740                 745                 750
Ser Arg Gly Phe Gly Ser Ser Ala Pro Glu Gly Leu Glu Pro Asp Ser
        755                 760                 765
Met Ala Ser Ala Ala Ser Ala Leu His Leu Leu Ser Pro Arg Pro Arg
    770                 775                 780
Pro Gly Pro Glu Leu Gly Pro Gln Leu Gly Leu Asp Gly Gly Pro Gly
785                 790                 795                 800
Asp Gly Asp Arg His Asn Thr Pro Ser Leu Leu Glu Ala Ala Leu Thr
                805                 810                 815
Gln Glu Ala Ser Thr Pro Asp Ser Gln Val Trp Pro Thr Ala Pro Asp
            820                 825                 830
Ile Thr Arg Glu Thr Cys Ser Thr Leu Ala Glu Ser Pro Arg Asn Gly
        835                 840                 845
Leu Gln Glu Lys His Lys Ser Leu Ala Phe His Arg Pro Pro Tyr His
    850                 855                 860
Leu Leu Gln Gln Arg Asp Ser Gln Asp Ala Ser Ala Glu Gln Ser Asp
865                 870                 875                 880
His Asp Asp Glu Val Ala Ser Leu Ala Ser Ala Ser Gly Gly Phe Gly
                885                 890                 895
Thr Lys Val Pro Ala Pro Arg Leu Pro Ala Lys Asp Trp Lys Thr Lys
            900                 905                 910
Gly Ser Pro Arg Thr Ser Pro Lys Leu Lys Arg Lys Ser Lys Lys Asp
        915                 920                 925
Asp Gly Asp Ala Ala Met Gly Ser Arg Leu Thr Glu His Gln Val Ala
    930                 935                 940
Glu Pro Pro Glu Asp Trp Pro Ala Leu Ile Trp Gln Gln Gln Arg Glu
945                 950                 955                 960
Leu Ala Glu Leu Arg His Ser Gln Glu Glu Leu Leu Gln Arg Leu Cys
                965                 970                 975
Thr Gln Leu Glu Gly Leu Gln Ser Thr Val Thr Gly His Val Glu Arg
            980                 985                 990
Ala Leu Glu Thr Arg His Glu Gln Glu Gln Arg Arg Leu Glu Arg Ala
        995                 1000                1005
Leu Ala Glu Gly Gln Gln Arg Gly Gly Gln Leu Gln Glu Gln Leu Thr
    1010                1015                1020
Gln Gln Leu Ser Gln Ala Leu Ser Ser Ala Val Ala Gly Arg Leu Glu
1025                1030                1035                1040
Arg Ser Ile Arg Asp Glu Ile Lys Lys Thr Val Pro Pro Cys Val Ser
                1045                1050                1055
Arg Ser Leu Glu Pro Met Ala Gly Gln Leu Ser Asn Ser Val Ala Thr
            1060                1065                1070
Lys Leu Thr Ala Val Glu Gly Ser Met Lys Glu Asn Ile Ser Lys Leu
        1075                1080                1085
Leu Lys Ser Lys Asn Leu Thr Asp Ala Ile Ala Arg Ala Ala Ala Asp
    1090                1095                1100
Thr Leu Gln Gly Pro Met Gln Ala Ala Tyr Arg Glu Ala Phe Gln Ser
1105                1110                1115                1120
Val Val Leu Pro Ala Phe Glu Lys Ser Cys Gln Ala Met Phe Gln Gln
                1125                1130                1135
Ile Asn Asp Ser Phe Arg Leu Gly Thr Gln Glu Tyr Leu Gln Gln Leu
            1140                1145                1150
Glu Ser His Met Lys Ser Arg Lys Ala Arg Glu Gln Glu Ala Arg Glu
        1155                1160                1165
Pro Val Leu Ala Gln Leu Arg Gly Leu Val Ser Thr Leu Gln Ser Ala
    1170                1175                1180
Thr Glu Gln Met Ala Ala Thr Val Ala Gly Ser Val Arg Ala Glu Val
1185                1190                1195                1200
Gln His Gln Leu His Val Ala Val Gly Ser Leu Gln Glu Ser Ile Leu
                1205                1210                1215
Ala Gln Val Gln Arg Ile Val Lys Gly Glu Val Ser Val Ala Leu Lys
            1220                1225                1230
Glu Gln Gln Ala Ala Val Thr Ser Ser Ile Met Gln Ala Met Arg Ser
        1235                1240                1245
Ala Ala Gly Thr Pro Val Pro Ser Ala His Leu Asp Cys Gln Ala Gln
    1250                1255                1260
Gln Ala His Ile Leu Gln Leu Leu Gln Gln Gly His Leu Asn Gln Ala
1265                1270                1275                1280
Phe Gln Gln Ala Leu Thr Ala Ala Asp Leu Asn Leu Val Leu Tyr Val
                1285                1290                1295
Cys Glu Thr Val Asp Pro Ala Gln Val Phe Gly Gln Pro Pro Cys Pro
            1300                1305                1310
Leu Ser Gln Pro Val Leu Leu Ser Leu Ile Gln Gln Leu Ala Ser Asp
        1315                1320                1325
Leu Gly Thr Arg Thr Asp Leu Lys Leu Ser Tyr Leu Glu Glu Ala Val
    1330                1335                1340
Met His Leu Asp His Ser Asp Pro Ile Thr Arg Asp His Met Gly Ser
1345                1350                1355                1360
Val Met Ala Gln Val Arg Gln Lys Leu Phe Gln Phe Leu Gln Ala Glu
                1365                1370                1375
Pro His Asn Ser Leu Gly Lys Ala Ala Arg Arg Leu Ser Leu Met Leu
            1380                1385                1390
His Gly Leu Val Thr Pro Ser Leu Pro
        1395                1400

<210> 46
<211> 226
<212> PRT
<213> Homo sapiens

<400> 46
Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe
 1               5                  10                  15
Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala
            20                  25                  30
Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu
        35                  40                  45
Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val
    50                  55                  60
Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe
65                  70                  75                  80
Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val
                85                  90                  95
Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn
            100                 105                 110
Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro
        115                 120                 125
Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile
    130                 135                 140
Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly
145                 150                 155                 160
Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu
                165                 170                 175
Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn
            180                 185                 190
Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly
        195                 200                 205
Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu
    210                 215                 220
Lys Pro
225

<210> 47
<211> 500
<212> PRT
<213> Homo sapiens

<400> 47
Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly
 1               5                  10                  15
Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe
            20                  25                  30
Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu
        35                  40                  45
Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile
    50                  55                  60
Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val
65                  70                  75                  80
Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser
                85                  90                  95
Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu
            100                 105                 110
Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu
        115                 120                 125
Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro
    130                 135                 140
Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr
145                 150                 155                 160
Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly
                165                 170                 175
Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly
            180                 185                 190
Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp
        195                 200                 205
Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys
    210                 215                 220
Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln
225                 230                 235                 240
Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr
                245                 250                 255
Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile
            260                 265                 270
Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly
        275                 280                 285
Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile
    290                 295                 300
Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala
305                 310                 315                 320
Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser
                325                 330                 335
Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr
            340                 345                 350
Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly
        355                 360                 365
Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro
    370                 375                 380
Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys
385                 390                 395                 400
Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr
                405                 410                 415
Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile
            420                 425                 430
Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu
        435                 440                 445
Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu
    450                 455                 460
Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala
465                 470                 475                 480
Ala Glu Ser Pro Asp Gln Lys Asp Thr Asp Gly Gly Pro Lys Glu Glu
                485                 490                 495
Glu Ser Pro Val
            500

<210> 48
<211> 930
<212> PRT
<213> Homo sapiens

<400> 48
Met Glu Tyr Glu Arg Arg Gly Gly Arg Gly Asp Arg Thr Gly Arg Tyr
 1               5                  10                  15
Gly Ala Thr Asp Arg Ser Gln Asp Asp Gly Gly Glu Asn Arg Ser Arg
            20                  25                  30
Asp His Asp Tyr Arg Asp Met Asp Tyr Arg Ser Tyr Pro Arg Glu Tyr
        35                  40                  45
Gly Ser Gln Glu Gly Lys His Asp Tyr Asp Asp Ser Ser Glu Glu Gln
    50                  55                  60
Ser Ala Glu Asp Ser Tyr Glu Ala Ser Pro Gly Ser Glu Thr Gln Arg
65                  70                  75                  80
Arg Arg Arg Arg Arg His Arg His Ser Pro Thr Gly Pro Pro Gly Phe
                85                  90                  95
Pro Arg Asp Gly Asp Tyr Arg Asp Gln Asp Tyr Arg Thr Glu Gln Gly
            100                 105                 110
Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Lys Ala Ser
        115                 120                 125
Asn Ile Val Met Leu Arg Met Leu Pro Gln Ala Ala Thr Glu Asp Asp
    130                 135                 140
Ile Arg Gly Gln Leu Gln Ser His Gly Val Gln Ala Arg Glu Val Arg
145                 150                 155                 160
Leu Met Arg Asn Lys Ser Ser Gly Gln Ser Arg Gly Phe Ala Phe Val
                165                 170                 175
Glu Phe Ser His Leu Gln Asp Ala Thr Arg Trp Met Glu Ala Asn Gln
            180                 185                 190
His Ser Leu Asn Ile Leu Gly Gln Lys Val Ser Met His Tyr Ser Asp
        195                 200                 205
Pro Lys Pro Lys Ile Asn Glu Asp Trp Leu Cys Asn Lys Cys Gly Val
    210                 215                 220
Gln Asn Phe Lys Arg Arg Glu Lys Cys Phe Lys Cys Gly Val Pro Lys
225                 230                 235                 240
Ser Glu Ala Glu Gln Lys Leu Pro Leu Gly Thr Arg Leu Asp Gln Gln
                245                 250                 255
Thr Leu Pro Leu Gly Gly Arg Glu Leu Ser Gln Gly Leu Leu Pro Leu
            260                 265                 270
Pro Gln Pro Tyr Gln Ala Gln Gly Val Leu Ala Ser Gln Ala Leu Ser
        275                 280                 285
Gln Gly Ser Glu Pro Ser Ser Glu Asn Ala Asn Asp Thr Ile Ile Leu
    290                 295                 300
Arg Asn Leu Asn Pro His Ser Thr Met Asp Ser Ile Leu Gly Ala Leu
305                 310                 315                 320
Ala Pro Tyr Ala Val Leu Ser Ser Ser Asn Val Arg Val Ile Lys Asp
                325                 330                 335
Lys Gln Thr Gln Leu Asn Arg Gly Phe Ala Phe Ile Gln Leu Ser Thr
            340                 345                 350
Ile Val Glu Ala Ala Gln Leu Leu Gln Ile Leu Gln Ala Leu His Pro
        355                 360                 365
Pro Leu Thr Ile Asp Gly Lys Thr Ile Asn Val Glu Phe Ala Lys Gly
    370                 375                 380
Ser Lys Arg Asp Met Ala Ser Asn Glu Gly Ser Arg Ile Ser Ala Ala
385                 390                 395                 400
Ser Val Ala Ser Thr Ala Ile Ala Ala Ala Gln Trp Ala Ile Ser Gln
                405                 410                 415
Ala Ser Gln Gly Gly Glu Gly Thr Trp Ala Thr Ser Glu Glu Pro Pro
            420                 425                 430
Val Asp Tyr Ser Tyr Tyr Gln Gln Asp Glu Gly Tyr Gly Asn Ser Gln
        435                 440                 445
Gly Thr Glu Ser Ser Leu Tyr Ala His Gly Tyr Leu Lys Gly Thr Lys
    450                 455                 460
Gly Pro Gly Ile Thr Gly Thr Lys Gly Asp Pro Thr Gly Ala Gly Pro
465                 470                 475                 480
Glu Ala Ser Leu Glu Pro Gly Ala Asp Ser Val Ser Met Gln Ala Phe
                485                 490                 495
Ser Arg Ala Gln Pro Gly Ala Ala Pro Gly Ile Tyr Gln Gln Ser Ala
            500                 505                 510
Glu Ala Ser Ser Ser Gln Gly Thr Ala Ala Asn Ser Gln Ser Tyr Thr
        515                 520                 525
Ile Met Ser Pro Ala Val Leu Lys Ser Glu Leu Gln Ser Pro Thr His
    530                 535                 540
Pro Ser Ser Ala Leu Pro Pro Ala Thr Ser Pro Thr Ala Gln Glu Ser
545                 550                 555                 560
Tyr Ser Gln Tyr Pro Val Pro Asp Val Ser Thr Tyr Gln Tyr Asp Glu
                565                 570                 575
Thr Ser Gly Tyr Tyr Tyr Asp Pro Gln Thr Gly Leu Tyr Tyr Asp Pro
            580                 585                 590
Asn Ser Gln Tyr Tyr Tyr Asn Ala Gln Ser Gln Gln Tyr Leu Tyr Trp
        595                 600                 605
Asp Gly Glu Arg Arg Thr Tyr Val Pro Ala Leu Glu Gln Ser Ala Asp
    610                 615                 620
Gly His Lys Glu Thr Gly Ala Pro Ser Lys Glu Gly Lys Glu Lys Lys
625                 630                 635                 640
Glu Lys His Lys Thr Lys Thr Ala Gln Gln Ile Ala Lys Asp Met Glu
                645                 650                 655
Arg Trp Ala Arg Ser Leu Asn Lys Gln Lys Glu Asn Phe Lys Asn Ser
            660                 665                 670
Phe Gln Pro Ile Ser Ser Leu Arg Asp Asp Glu Arg Arg Glu Ser Ala
        675                 680                 685
Thr Ala Asp Ala Gly Tyr Ala Ile Leu Glu Lys Lys Gly Ala Leu Ala
    690                 695                 700
Glu Arg Gln His Thr Ser Met Asp Leu Pro Lys Leu Ala Ser Asp Asp
705                 710                 715                 720
Arg Pro Ser Pro Pro Arg Gly Leu Val Ala Ala Tyr Ser Gly Glu Ser
                725                 730                 735
Asp Ser Glu Glu Glu Gln Glu Arg Gly Gly Pro Glu Arg Glu Glu Lys
            740                 745                 750
Leu Thr Asp Trp Gln Lys Leu Ala Cys Leu Leu Cys Arg Arg Gln Phe
        755                 760                 765
Pro Ser Lys Glu Ala Leu Ile Arg His Gln Gln Leu Ser Gly Leu His
    770                 775                 780
Lys Gln Asn Leu Glu Ile His Arg Arg Ala His Leu Ser Glu Asn Glu
785                 790                 795                 800
Leu Glu Ala Leu Glu Lys Asn Asp Met Glu Gln Met Lys Tyr Arg Asp
                805                 810                 815
Arg Ala Ala Glu Arg Arg Glu Lys Tyr Gly Ile Pro Glu Pro Pro Glu
            820                 825                 830
Pro Lys Arg Arg Lys Tyr Gly Gly Ile Ser Thr Ala Ser Val Asp Phe
        835                 840                 845
Glu Gln Pro Thr Arg Asp Gly Leu Gly Ser Asp Asn Ile Gly Ser Arg
    850                 855                 860
Met Leu Gln Ala Met Gly Trp Lys Glu Gly Ser Gly Leu Gly Arg Lys
865                 870                 875                 880
Lys Gln Gly Ile Val Thr Pro Ile Glu Ala Gln Thr Arg Val Arg Gly
                885                 890                 895
Ser Gly Leu Gly Ala Arg Gly Ser Ser Tyr Gly Val Thr Ser Thr Glu
            900                 905                 910
Ser Tyr Lys Glu Thr Leu His Lys Thr Met Val Thr Arg Phe Asn Glu
        915                 920                 925
Ala Gln
    930

<210> 49
<211> 348
<212> PRT
<213> Homo sapiens

<400> 49
Met Ala Glu Lys Val Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser
 1               5                  10                  15
His Thr Val Leu Glu Leu Leu Glu Ala Gly Tyr Leu Pro Val Val Ile
            20                  25                  30
Asp Asn Phe His Asn Ala Phe Arg Gly Gly Gly Ser Leu Pro Glu Ser
        35                  40                  45
Leu Arg Arg Val Gln Glu Leu Thr Gly Arg Ser Val Glu Phe Glu Glu
    50                  55                  60
Met Asp Ile Leu Asp Gln Gly Ala Leu Gln Arg Leu Phe Lys Lys Tyr
65                  70                  75                  80
Ser Phe Met Ala Val Ile His Phe Ala Gly Leu Lys Ala Val Gly Glu
                85                  90                  95
Ser Val Gln Lys Pro Leu Asp Tyr Tyr Arg Val Asn Leu Thr Gly Thr
            100                 105                 110
Ile Gln Leu Leu Glu Ile Met Lys Ala His Gly Val Lys Asn Leu Val
        115                 120                 125
Phe Ser Ser Ser Ala Thr Val Tyr Gly Asn Pro Gln Tyr Leu Pro Leu
    130                 135                 140
Asp Glu Ala His Pro Thr Gly Gly Cys Thr Asn Pro Tyr Gly Lys Ser
145                 150                 155                 160
Lys Phe Phe Ile Glu Glu Met Ile Arg Asp Leu Cys Gln Ala Asp Lys
                165                 170                 175
Thr Trp Asn Ala Val Leu Leu Arg Tyr Phe Asn Pro Thr Gly Ala His
            180                 185                 190
Ala Ser Gly Cys Ile Gly Glu Asp Pro Gln Gly Ile Pro Asn Asn Leu
        195                 200                 205
Met Pro Tyr Val Ser Gln Val Ala Ile Gly Arg Arg Glu Ala Leu Asn
    210                 215                 220
Val Phe Gly Asn Asp Tyr Asp Thr Glu Asp Gly Thr Gly Val Arg Asp
225                 230                 235                 240
Tyr Ile His Val Val Asp Leu Ala Lys Gly His Ile Ala Ala Leu Arg
                245                 250                 255
Lys Leu Lys Glu Gln Cys Gly Cys Arg Ile Tyr Asn Leu Gly Thr Gly
            260                 265                 270
Thr Gly Tyr Ser Val Leu Gln Met Val Gln Ala Met Glu Lys Ala Ser
        275                 280                 285
Gly Lys Lys Ile Pro Tyr Lys Val Val Ala Arg Arg Glu Gly Asp Val
    290                 295                 300
Ala Ala Cys Tyr Ala Asn Pro Ser Leu Ala Gln Glu Glu Leu Gly Trp
305                 310                 315                 320
Thr Ala Ala Leu Gly Leu Asp Arg Met Cys Glu Asp Leu Trp Arg Trp
                325                 330                 335
Gln Lys Gln Asn Pro Ser Gly Phe Gly Thr Gln Ala
            340                 345

<210> 50
<211> 365
<212> PRT
<213> Homo sapiens

<400> 50
Met Gly Arg Lys Lys Ile Gln Ile Ser Arg Ile Leu Asp Gln Arg Asn
 1               5                  10                  15
Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala
            20                  25                  30
Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe
        35                  40                  45
Asn Ser Ala Asn Arg Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Arg
    50                  55                  60
Val Leu Leu Lys Tyr Thr Glu Tyr Ser Glu Pro His Glu Ser Arg Thr
65                  70                  75                  80
Asn Thr Asp Ile Leu Glu Thr Leu Lys Arg Arg Gly Ile Gly Leu Asp
                85                  90                  95
Gly Pro Glu Leu Glu Pro Asp Glu Gly Pro Glu Glu Pro Gly Glu Lys
            100                 105                 110
Phe Arg Arg Leu Ala Gly Glu Gly Gly Asp Pro Ala Leu Pro Arg Pro
        115                 120                 125
Arg Leu Tyr Pro Ala Ala Pro Ala Met Pro Ser Pro Asp Val Val Tyr
    130                 135                 140
Gly Ala Leu Pro Pro Pro Gly Cys Asp Pro Ser Gly Leu Gly Glu Ala
145                 150                 155                 160
Leu Pro Ala Gln Ser Arg Pro Ser Pro Phe Arg Pro Ala Ala Pro Lys
                165                 170                 175
Ala Gly Pro Pro Gly Leu Val His Pro Leu Phe Ser Pro Ser His Leu
            180                 185                 190
Thr Ser Lys Thr Pro Pro Pro Leu Tyr Leu Pro Thr Glu Gly Arg Arg
        195                 200                 205
Ser Asp Leu Pro Gly Gly Leu Ala Gly Pro Arg Gly Gly Leu Asn Thr
    210                 215                 220
Ser Arg Ser Leu Tyr Ser Gly Leu Gln Asn Pro Cys Ser Thr Ala Thr
225                 230                 235                 240
Pro Gly Pro Pro Leu Gly Ser Phe Pro Phe Leu Pro Gly Gly Pro Pro
                245                 250                 255
Val Gly Ala Glu Ala Trp Ala Arg Arg Val Pro Gln Pro Ala Ala Pro
            260                 265                 270
Pro Arg Arg Pro Pro Gln Ser Ala Ser Ser Leu Ser Ala Ser Leu Arg
        275                 280                 285
Pro Pro Gly Ala Pro Ala Thr Phe Leu Arg Pro Ser Pro Ile Pro Cys
    290                 295                 300
Ser Ser Pro Gly Pro Trp Gln Ser Leu Cys Gly Leu Gly Pro Pro Cys
305                 310                 315                 320
Ala Gly Cys Pro Trp Pro Thr Ala Gly Pro Gly Arg Arg Ser Pro Gly
                325                 330                 335
Gly Thr Ser Pro Glu Arg Ser Pro Gly Thr Ala Arg Ala Arg Gly Asp
            340                 345                 350
Pro Thr Ser Leu Gln Ala Ser Ser Glu Lys Thr Gln Gln
        355                 360                 365

<210> 51
<211> 163
<212> PRT
<213> Homo sapiens

<400> 51
Met Val Gly Gly Gly Gly Val Gly Gly Gly Leu Leu Glu Asn Ala Asn
 1               5                  10                  15
Pro Leu Ile Tyr Gln Arg Ser Gly Glu Arg Pro Val Thr Ala Gly Glu
            20                  25                  30
Glu Asp Glu Gln Val Pro Asp Ser Ile Asp Ala Arg Glu Ile Phe Asp
        35                  40                  45
Leu Ile Arg Ser Ile Asn Asp Pro Glu His Pro Leu Thr Leu Glu Glu
    50                  55                  60
Leu Asn Val Val Glu Gln Val Arg Val Gln Val Ser Asp Pro Glu Ser
65                  70                  75                  80
Thr Val Ala Val Ala Phe Thr Pro Thr Ile Pro His Cys Ser Met Ala
                85                  90                  95
Thr Leu Ile Gly Leu Ser Ile Lys Val Lys Leu Leu Arg Ser Leu Pro
            100                 105                 110
Gln Arg Phe Lys Met Asp Val His Ile Thr Pro Gly Thr His Ala Ser
        115                 120                 125
Glu His Ala Val Asn Lys Gln Leu Ala Asp Lys Glu Arg Val Ala Ala
    130                 135                 140
Ala Leu Glu Asn Thr His Leu Leu Glu Val Val Asn Gln Cys Leu Ser
145                 150                 155                 160
Ala Arg Ser


<210> 52
<211> 892
<212> PRT
<213> Homo sapiens

<400> 52
Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala
 1               5                  10                  15
Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln
            20                  25                  30
Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln
        35                  40                  45
Gln His Pro Pro Pro Pro Pro Arg Arg Thr Arg Pro Glu Asp Gly Gly
    50                  55                  60
Pro Gly Ala Ala Ser Thr Ser Ala Ala Ala Met Ala Thr Val Gly Glu
65                  70                  75                  80
Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn
                85                  90                  95
Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Thr Glu Leu
            100                 105                 110
Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu
        115                 120                 125
Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp
    130                 135                 140
Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln
145                 150                 155                 160
Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro
                165                 170                 175
Pro Leu Ala Val Pro Pro Thr Ser Val Phe Ser Phe Phe Pro Ser Leu
            180                 185                 190
Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser
        195                 200                 205
Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser
    210                 215                 220
Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Thr Arg Pro Met His Pro
225                 230                 235                 240
Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Thr Pro Ser Val
                245                 250                 255
Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Thr Leu Leu Lys Ser
            260                 265                 270
Ala Val Gly Pro Thr Cys Pro Ala Thr Val Ser Ser Leu Val Lys Pro
        275                 280                 285
Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Thr Leu Pro Ser Pro Gly
    290                 295                 300
Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Thr Leu Glu Lys
305                 310                 315                 320
Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu
                325                 330                 335
Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu
            340                 345                 350
Asp Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr His Ser
        355                 360                 365
Leu Thr Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val
    370                 375                 380
Leu Leu Ala Glu His Lys Asn Lys Thr Arg Glu Lys Glu Leu Ile Arg
385                 390                 395                 400
His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro
                405                 410                 415
Ala Pro Pro Arg Thr Ser Gln Glu Pro His Gln Asn Pro His Gly Val
            420                 425                 430
Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His
        435                 440                 445
Thr Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly
    450                 455                 460
Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro
465                 470                 475                 480
Leu Pro Ala Thr Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu
                485                 490                 495
Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser
            500                 505                 510
Gly His His Pro Gln Pro Ala Ser Phe Cys Thr Phe Gly Ser Arg Gln
        515                 520                 525
Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg
    530                 535                 540
Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp
545                 550                 555                 560
Lys Lys Ile Pro Pro Val Pro Ser Thr Thr Ser Pro Ile Ser Thr Arg
                565                 570                 575
Ile Pro His Arg Thr Asn Ser Val Pro Thr Ser Gln Cys Gly Val Ser
            580                 585                 590
Tyr Leu Ala Ala Ala Thr Val Ser Thr Ser Pro Val Leu Leu Ser Ser
        595                 600                 605
Thr Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Thr Thr
    610                 615                 620
Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser
625                 630                 635                 640
Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro
                645                 650                 655
Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln
            660                 665                 670
Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn
        675                 680                 685
Ser Thr Asn Cys Gln Asn Ala Ser Ser Ser Thr Ser Gly Gly Ser Gly
    690                 695                 700
Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser
705                 710                 715                 720
Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys
                725                 730                 735
Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Thr Val Thr Ser
            740                 745                 750
Ser His Ser Ile Gly Leu Asn Cys Val Thr Asn Lys Ala Asn Ala Val
        755                 760                 765
Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Thr Gly Ser Pro
    770                 775                 780
Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser
785                 790                 795                 800
Thr Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val
                805                 810                 815
Asn Ser His Gly Ser Phe Ser His Ser His Thr Pro Leu Asp Lys Leu
            820                 825                 830
Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn
        835                 840                 845
Ser Ser Ser Lys Pro Thr Lys Val Ala Lys Val Pro Ala Val Asn Asn
    850                 855                 860
Val His Met Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met
865                 870                 875                 880
Asn Ser Ser Leu Leu His Gln Pro Lys Ala Arg Pro
                885                 890

<210> 53
<211> 612
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Thr Ala Ala Thr Ile Pro Ser Val Ala Thr Ala Thr Ala Ala
 1               5                  10                  15
Ala Leu Gly Glu Val Glu Asp Glu Gly Leu Leu Ala Ser Leu Phe Arg
            20                  25                  30
Asp Arg Phe Pro Glu Ala Gln Trp Arg Glu Arg Pro Asp Val Gly Arg
        35                  40                  45
Tyr Leu Arg Glu Leu Ser Gly Ser Gly Leu Glu Arg Leu Arg Arg Glu
    50                  55                  60
Pro Glu Arg Leu Ala Glu Glu Arg Ala Gln Leu Leu Gln Gln Thr Arg
65                  70                  75                  80
Asp Leu Ala Phe Ala Asn Tyr Lys Thr Phe Ile Arg Gly Ala Glu Cys
                85                  90                  95
Thr Glu Arg Ile His Arg Leu Phe Gly Asp Val Glu Ala Ser Leu Gly
            100                 105                 110
Arg Leu Leu Asp Arg Leu Pro Ser Phe Gln Gln Ser Cys Arg Asn Phe
        115                 120                 125
Val Lys Glu Ala Glu Glu Ile Ser Ser Asn Arg Arg Met Asn Ser Leu
    130                 135                 140
Thr Leu Asn Arg His Thr Glu Ile Leu Glu Ile Leu Glu Ile Pro Gln
145                 150                 155                 160
Leu Met Asp Thr Cys Val Arg Asn Ser Tyr Tyr Glu Glu Ala Leu Glu
                165                 170                 175
Leu Ala Ala Tyr Val Arg Arg Leu Glu Arg Lys Tyr Ser Ser Ile Pro
            180                 185                 190
Val Ile Gln Gly Ile Val Asn Glu Val Arg Gln Ser Met Gln Leu Met
        195                 200                 205
Leu Ser Gln Leu Ile Gln Gln Leu Arg Thr Asn Ile Gln Leu Pro Ala
    210                 215                 220
Cys Leu Arg Val Ile Gly Tyr Leu Arg Arg Met Asp Val Phe Thr Glu
225                 230                 235                 240
Ala Glu Leu Arg Val Lys Phe Leu Gln Ala Arg Asp Ala Trp Leu Arg
                245                 250                 255
Ser Ile Leu Thr Ala Ile Pro Asn Asp Asp Pro Tyr Phe His Ile Thr
            260                 265                 270
Lys Thr Ile Glu Ala Ser Arg Val His Leu Phe Asp Ile Ile Thr Gln
        275                 280                 285
Tyr Arg Ala Ile Phe Ser Asp Glu Asp Pro Leu Leu Pro Pro Ala Met
    290                 295                 300
Gly Glu His Thr Val Asn Glu Ser Ala Ile Phe His Gly Trp Val Leu
305                 310                 315                 320
Gln Lys Val Ser Gln Phe Leu Gln Val Leu Glu Thr Asp Leu Tyr Arg
                325                 330                 335
Gly Ile Gly Gly His Leu Asp Ser Leu Leu Gly Gln Cys Met Tyr Phe
            340                 345                 350
Gly Leu Ser Phe Ser Arg Val Gly Ala Asp Phe Arg Gly Gln Leu Ala
        355                 360                 365
Pro Val Phe Gln Arg Val Ala Ile Ser Thr Phe Gln Lys Ala Ile Gln
    370                 375                 380
Glu Thr Val Glu Lys Phe Gln Glu Glu Met Asn Ser Tyr Met Leu Ile
385                 390                 395                 400
Ser Ala Pro Ala Ile Leu Gly Thr Ser Asn Met Pro Ala Ala Val Pro
                405                 410                 415
Ala Thr Gln Pro Gly Thr Leu Gln Pro Pro Met Val Leu Leu Asp Phe
            420                 425                 430
Pro Pro Leu Ala Cys Phe Leu Asn Asn Ile Leu Val Ala Phe Asn Asp
        435                 440                 445
Leu Arg Leu Cys Cys Pro Val Ala Leu Ala Gln Asp Val Thr Gly Ala
    450                 455                 460
Leu Glu Asp Ala Leu Ala Lys Val Thr Lys Ile Ile Leu Ala Phe His
465                 470                 475                 480
Arg Ala Glu Glu Ala Ala Phe Ser Ser Gly Glu Gln Glu Leu Phe Val
                485                 490                 495
Gln Phe Cys Thr Val Phe Leu Glu Asp Leu Val Pro Tyr Leu Asn Arg
            500                 505                 510
Cys Leu Gln Val Leu Phe Pro Pro Ala Gln Ile Ala Gln Thr Leu Gly
        515                 520                 525
Ile Pro Pro Thr Gln Leu Ser Lys Tyr Gly Asn Leu Gly His Val Asn
    530                 535                 540
Ile Gly Ala Ile Gln Glu Pro Leu Ala Phe Ile Leu Pro Lys Arg Glu
545                 550                 555                 560
Thr Leu Phe Thr Leu Asp Asp Gln Ala Leu Gly Pro Glu Leu Thr Ala
                565                 570                 575
Pro Ala Pro Glu Pro Pro Ala Glu Glu Pro Arg Leu Glu Pro Ala Gly
            580                 585                 590
Pro Ala Cys Pro Glu Gly Gly Arg Ala Glu Thr Gln Ala Glu Pro Pro
        595                 600                 605
Ser Val Gly Pro
    610

<210> 54
<211> 251
<212> PRT
<213> Homo sapiens

<400> 54
Met Ser Asp Ile Gly Asp Trp Phe Arg Ser Ile Pro Ala Ile Thr Arg
 1               5                  10                  15
Tyr Trp Phe Ala Ala Thr Val Ala Val Pro Leu Val Gly Lys Leu Gly
            20                  25                  30
Leu Ile Ser Pro Ala Tyr Leu Phe Leu Trp Pro Glu Ala Phe Leu Tyr
        35                  40                  45
Arg Phe Gln Ile Trp Arg Pro Ile Thr Ala Thr Phe Tyr Phe Pro Val
    50                  55                  60
Gly Pro Gly Thr Gly Phe Leu Tyr Leu Val Asn Leu Tyr Phe Leu Tyr
65                  70                  75                  80
Gln Tyr Ser Thr Arg Leu Glu Thr Gly Ala Phe Asp Gly Arg Pro Ala
                85                  90                  95
Asp Tyr Leu Phe Met Leu Leu Phe Asn Trp Ile Cys Ile Val Ile Thr
            100                 105                 110
Gly Leu Ala Met Asp Met Gln Leu Leu Met Ile Pro Leu Ile Met Ser
        115                 120                 125
Val Leu Tyr Val Trp Ala Gln Leu Asn Arg Asp Met Ile Val Ser Phe
    130                 135                 140
Trp Phe Gly Thr Arg Phe Lys Ala Cys Tyr Leu Pro Trp Val Ile Leu
145                 150                 155                 160
Gly Phe Asn Tyr Ile Ile Gly Gly Ser Val Ile Asn Glu Leu Ile Gly
                165                 170                 175
Asn Leu Val Gly His Leu Tyr Phe Phe Leu Met Phe Arg Tyr Pro Met
            180                 185                 190
Asp Leu Gly Gly Arg Asn Phe Leu Ser Thr Pro Gln Phe Leu Tyr Arg
        195                 200                 205
Trp Leu Pro Ser Arg Arg Gly Gly Val Ser Gly Phe Gly Val Pro Pro
    210                 215                 220
Ala Ser Met Arg Arg Ala Ala Asp Gln Asn Gly Gly Gly Gly Arg His
225                 230                 235                 240
Asn Trp Gly Gln Gly Phe Arg Leu Gly Asp Gln
                245                 250

<210> 55
<211> 567
<212> PRT
<213> Homo sapiens

<400> 55
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu
 1               5                  10                  15
Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val
            20                  25                  30
Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro
        35                  40                  45
Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln
    50                  55                  60
Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro
65                  70                  75                  80
Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr
                85                  90                  95
Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile
            100                 105                 110
Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys
        115                 120                 125
Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn
    130                 135                 140
Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu
145                 150                 155                 160
Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu
                165                 170                 175
Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn
            180                 185                 190
Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys
        195                 200                 205
Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg
    210                 215                 220
Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu
225                 230                 235                 240
Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala
                245                 250                 255
Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu
            260                 265                 270
Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys
        275                 280                 285
Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile
    290                 295                 300
Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln
305                 310                 315                 320
Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr
                325                 330                 335
Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser
            340                 345                 350
Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys
        355                 360                 365
Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn
    370                 375                 380
Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu
385                 390                 395                 400
Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser
                405                 410                 415
Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser
            420                 425                 430
Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr
        435                 440                 445
Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val
    450                 455                 460
Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu
465                 470                 475                 480
His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly
                485                 490                 495
Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met
            500                 505                 510
Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg
        515                 520                 525
Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu
    530                 535                 540
Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp
545                 550                 555                 560
Gly Ser Leu Asn Thr Thr Lys
                565

<210> 56
<211> 121
<212> PRT
<213> Homo sapiens

<400> 56
Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu
 1               5                  10                  15
Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr
            20                  25                  30
Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Gly
        35                  40                  45
Ile Pro Val Leu Ile Val Gly His His Ile Leu Tyr Gly Lys Ile Ile
    50                  55                  60
His Leu Glu Lys Pro Phe Ala Val Leu Val Lys His Thr Pro Gly Asp
65                  70                  75                  80
Gln Asp Cys Asp Glu Leu Gly Arg Glu Thr Gly Thr Arg Tyr Leu Val
                85                  90                  95
Thr Ala Leu Ile Lys Asp Lys Ile Leu Phe Lys Thr Arg Pro Lys Pro
            100                 105                 110
Ile Ile Thr Ser Val Pro Lys Lys Val
        115                 120

<210> 57
<211> 530
<212> PRT
<213> Homo sapiens

<400> 57
Met Ser Met Pro Asp Ala Met Pro Leu Pro Gly Val Gly Glu Glu Leu
 1               5                  10                  15
Lys Gln Ala Lys Glu Ile Glu Asp Ala Glu Lys Tyr Ser Phe Met Ala
            20                  25                  30
Thr Val Thr Lys Ala Pro Lys Lys Gln Ile Gln Phe Ala Asp Asp Met
        35                  40                  45
Gln Glu Phe Thr Lys Phe Pro Thr Lys Thr Gly Arg Arg Ser Leu Ser
    50                  55                  60
Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser
65                  70                  75                  80
Tyr Thr Asp Ser Ser Asp Asp Glu Val Ser Pro Arg Glu Lys Gln Gln
                85                  90                  95
Thr Asn Ser Lys Gly Ser Ser Asn Phe Cys Val Lys Asn Ile Lys Gln
            100                 105                 110
Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Asp Met Ser
        115                 120                 125
Ala Leu Ile Ser Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala
    130                 135                 140
Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val
145                 150                 155                 160
Leu Ile Glu Thr Leu Cys Ala Leu Gly Ala Gln Cys Arg Trp Ser Ala
                165                 170                 175
Cys Asn Ile Tyr Ser Thr Gln Asn Glu Val Ala Ala Ala Leu Ala Glu
            180                 185                 190
Ala Gly Val Ala Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe
        195                 200                 205
Trp Trp Cys Ile Asp Arg Cys Val Asn Met Asp Gly Trp Gln Ala Asn
    210                 215                 220
Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Val Tyr Lys Lys
225                 230                 235                 240
Tyr Pro Asn Val Phe Lys Lys Ile Arg Gly Ile Val Glu Glu Ser Val
                245                 250                 255
Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys
            260                 265                 270
Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp
        275                 280                 285
Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr
    290                 295                 300
Thr Asp Val Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly
305                 310                 315                 320
Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Leu Gly Ala Ile
                325                 330                 335
Val Tyr Ile Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met
            340                 345                 350
Asp Gly Phe Arg Val Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp
        355                 360                 365
Val Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu His
    370                 375                 380
Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser
385                 390                 395                 400
Asn Thr Glu Ile Asp Val Thr Ser Leu Arg Thr Pro Glu Leu Thr Trp
                405                 410                 415
Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys
            420                 425                 430
Arg Val Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser
        435                 440                 445
Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu
    450                 455                 460
Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp
465                 470                 475                 480
Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His
                485                 490                 495
Leu Pro Ser Phe Asp Ala His Leu Thr Glu Leu Thr Asp Asp Gln Ala
            500                 505                 510
Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr
        515                 520                 525
Arg Tyr
    530

<210> 58
<211> 431
<212> PRT
<213> Homo sapiens

<400> 58
Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala
 1               5                  10                  15
Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln
            20                  25                  30
Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His
        35                  40                  45
Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg
    50                  55                  60
Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro
65                  70                  75                  80
Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe
                85                  90                  95
Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu
            100                 105                 110
Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val
        115                 120                 125
Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg
    130                 135                 140
Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys
145                 150                 155                 160
Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn
                165                 170                 175
Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr
            180                 185                 190
Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met
        195                 200                 205
Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val
    210                 215                 220
Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala
225                 230                 235                 240
Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala
                245                 250                 255
Ala Asp Pro Pro Gln Pro His Ile Val Gly Ile Gln Ser Pro Asp Gln
            260                 265                 270
Gln Ala Ala Leu Ala Arg His Asn Pro Ala Arg Pro Val Phe Val Glu
        275                 280                 285
Gly Pro Phe Ser Leu Trp Leu Arg Asn Lys Cys Val Tyr Tyr His Ile
    290                 295                 300
Leu Arg Ala Asp Leu Leu Pro Pro Glu Glu Arg Glu Val Glu Glu Thr
305                 310                 315                 320
Pro Glu Glu Trp Asn Leu Tyr Tyr Pro Met Gln Leu Asp Leu Glu Tyr
                325                 330                 335
Val Arg Ser Gly Trp Asp Asn Tyr Glu Phe Asp Ile Asn Glu Val Glu
            340                 345                 350
Glu Gly Pro Val Phe Ala Met Cys Met Ala Gly Ala His Asp Gln Ala
        355                 360                 365
Thr Met Ala Lys Trp Ile Gln Gly Leu Gln Glu Thr Asn Pro Thr Leu
    370                 375                 380
Ala Gln Ile Pro Val Val Phe Arg Leu Ala Gly Ser Thr Arg Glu Leu
385                 390                 395                 400
Gln Thr Ser Ser Ala Gly Leu Glu Glu Pro Pro Leu Pro Glu Asp His
                405                 410                 415
Gln Glu Glu Asp Asp Asn Leu Gln Arg Gln Gln Gln Gly Gln Ser
            420                 425                 430

<210> 59
<211> 707
<212> PRT
<213> Homo sapiens

<400> 59
Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly
 1               5                  10                  15
Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln
            20                  25                  30
Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln
        35                  40                  45
Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro
    50                  55                  60
Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn
65                  70                  75                  80
Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu
                85                  90                  95
Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp
            100                 105                 110
Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser
        115                 120                 125
Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr
    130                 135                 140
Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro
145                 150                 155                 160
Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser
                165                 170                 175
Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu
            180                 185                 190
Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr
        195                 200                 205
Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg
    210                 215                 220
Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met
225                 230                 235                 240
Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu
                245                 250                 255
Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile
            260                 265                 270
Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu
        275                 280                 285
Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala
    290                 295                 300
Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu
305                 310                 315                 320
Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile
                325                 330                 335
Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys
            340                 345                 350
Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly
        355                 360                 365
Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile
    370                 375                 380
Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp
385                 390                 395                 400
Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr
                405                 410                 415
Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn
            420                 425                 430
Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala
        435                 440                 445
Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val
    450                 455                 460
Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp
465                 470                 475                 480
Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val
                485                 490                 495
Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg
            500                 505                 510
Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro
        515                 520                 525
Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val
    530                 535                 540
Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp
545                 550                 555                 560
Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr
                565                 570                 575
Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn
            580                 585                 590
Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile
        595                 600                 605
Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln
    610                 615                 620
Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser
625                 630                 635                 640
Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe
                645                 650                 655
Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val
            660                 665                 670
Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser
        675                 680                 685
Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val
    690                 695                 700
Asp Met Lys
705

<210> 60
<211> 262
<212> PRT
<213> Homo sapiens

<400> 60
Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Phe Ser Cys
 1               5                  10                  15
Leu Tyr Pro Asp Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys His Ser
            20                  25                  30
Ser Tyr Pro Asp Ser Glu Gly Ala Pro Asp Ser Leu Trp Asp Trp Thr
        35                  40                  45
Val Ala Pro Pro Val Pro Ala Thr Pro Tyr Glu Ala Phe Asp Pro Ala
    50                  55                  60
Ala Ala Ala Phe Ser His Pro Gln Ala Ala Gln Leu Cys Tyr Glu Pro
65                  70                  75                  80
Pro Thr Tyr Ser Pro Ala Gly Asn Leu Glu Leu Ala Pro Ser Leu Glu
                85                  90                  95
Ala Pro Gly Pro Gly Leu Pro Ala Tyr Pro Thr Glu Asn Phe Ala Ser
            100                 105                 110
Gln Thr Leu Val Pro Pro Ala Tyr Ala Pro Tyr Pro Ser Pro Val Leu
        115                 120                 125
Ser Glu Glu Glu Asp Leu Pro Leu Asp Ser Pro Ala Leu Glu Val Ser
    130                 135                 140
Asp Ser Glu Ser Asp Glu Ala Leu Val Ala Gly Pro Glu Gly Lys Gly
145                 150                 155                 160
Ser Glu Ala Gly Thr Arg Lys Lys Leu Arg Leu Tyr Gln Phe Leu Leu
                165                 170                 175
Gly Leu Leu Thr Arg Gly Asp Met Arg Glu Cys Val Trp Trp Val Glu
            180                 185                 190
Pro Gly Ala Gly Val Phe Gln Phe Ser Ser Lys His Lys Glu Leu Leu
        195                 200                 205
Ala Arg Arg Trp Gly Gln Gln Lys Gly Asn Arg Lys Arg Met Thr Tyr
    210                 215                 220
Gln Lys Leu Ala Arg Ala Leu Arg Asn Tyr Ala Lys Thr Gly Glu Ile
225                 230                 235                 240
Arg Lys Val Lys Arg Lys Leu Thr Tyr Gln Phe Asp Ser Ala Leu Leu
                245                 250                 255
Pro Ala Val Arg Arg Ala
            260

<210> 61
<211> 325
<212> PRT
<213> Homo sapiens

<400> 61
Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile
 1               5                  10                  15
Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met
            20                  25                  30
Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile
        35                  40                  45
Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg
    50                  55                  60
Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn
65                  70                  75                  80
Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp
                85                  90                  95
Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu
            100                 105                 110
Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser
        115                 120                 125
Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser
    130                 135                 140
Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp
145                 150                 155                 160
His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu
                165                 170                 175
Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu
            180                 185                 190
Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp
        195                 200                 205
Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr
    210                 215                 220
Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu
225                 230                 235                 240
Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr
                245                 250                 255
Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe
            260                 265                 270
Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly
        275                 280                 285
Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr
    290                 295                 300
Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala
305                 310                 315                 320
Ile Pro Cys Ala Pro
                325

<210> 62
<211> 1866
<212> PRT
<213> Homo sapiens

<400> 62
Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys
 1               5                  10                  15
Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met
            20                  25                  30
Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu
        35                  40                  45
Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln
    50                  55                  60
Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu
65                  70                  75                  80
Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr
                85                  90                  95
Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro
            100                 105                 110
Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly
        115                 120                 125
Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala
    130                 135                 140
Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg
145                 150                 155                 160
Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr
                165                 170                 175
Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu
            180                 185                 190
Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser
        195                 200                 205
Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr
    210                 215                 220
Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg
225                 230                 235                 240
Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu
                245                 250                 255
Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr
            260                 265                 270
Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His
        275                 280                 285
Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu
    290                 295                 300
Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly
305                 310                 315                 320
Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu
                325                 330                 335
Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro
            340                 345                 350
Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp
        355                 360                 365
Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro
    370                 375                 380
Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg
385                 390                 395                 400
Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu
                405                 410                 415
His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu
            420                 425                 430
Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro
        435                 440                 445
Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala
    450                 455                 460
Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile
465                 470                 475                 480
Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser
                485                 490                 495
Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe
            500                 505                 510
Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala
        515                 520                 525
Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His
    530                 535                 540
Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His
545                 550                 555                 560
Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe
                565                 570                 575
Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln
            580                 585                 590
Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr
        595                 600                 605
Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu
    610                 615                 620
Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro
625                 630                 635                 640
Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn
                645                 650                 655
Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys
            660                 665                 670
Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile
        675                 680                 685
Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu
    690                 695                 700
Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly
705                 710                 715                 720
Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys
                725                 730                 735
Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn
            740                 745                 750
Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His
        755                 760                 765
Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val
    770                 775                 780
Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val
785                 790                 795                 800
Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro
                805                 810                 815
Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu
            820                 825                 830
Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg
        835                 840                 845
Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala
    850                 855                 860
Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn
865                 870                 875                 880
Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln
                885                 890                 895
Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val
            900                 905                 910
Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu
        915                 920                 925
Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe
    930                 935                 940
Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe
945                 950                 955                 960
Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser
                965                 970                 975
Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu
            980                 985                 990
Gln Leu Cys Lys Ala Leu Gly Gly Ser Cys His Leu Gly His Leu His
        995                 1000                1005
Leu Asp Phe Ser Gly Asn Ala Leu Gly Asp Glu Gly Ala Ala Arg Leu
    1010                1015                1020
Ala Gln Leu Leu Pro Gly Leu Gly Ala Leu Gln Ser Leu Asn Leu Ser
1025                1030                1035                1040
Glu Asn Gly Leu Ser Leu Asp Ala Val Leu Gly Leu Val Arg Cys Phe
                1045                1050                1055
Ser Thr Leu Gln Trp Leu Phe Arg Leu Asp Ile Ser Phe Glu Ser Gln
            1060                1065                1070
His Ile Leu Leu Arg Gly Asp Lys Thr Ser Arg Asp Met Trp Ala Thr
        1075                1080                1085
Gly Ser Leu Pro Asp Phe Pro Ala Ala Ala Lys Phe Leu Gly Phe Arg
    1090                1095                1100
Gln Arg Cys Ile Pro Arg Ser Leu Cys Leu Ser Glu Cys Pro Leu Glu
1105                1110                1115                1120
Pro Pro Ser Leu Thr Arg Leu Cys Ala Thr Leu Lys Asp Cys Pro Gly
                1125                1130                1135
Pro Leu Glu Leu Gln Leu Ser Cys Glu Phe Leu Ser Asp Gln Ser Leu
            1140                1145                1150
Glu Thr Leu Leu Asp Cys Leu Pro Gln Leu Pro Gln Leu Ser Leu Leu
        1155                1160                1165
Gln Leu Ser Gln Thr Gly Leu Ser Pro Lys Ser Pro Phe Leu Leu Ala
    1170                1175                1180
Asn Thr Leu Ser Leu Cys Pro Arg Val Lys Lys Val Asp Leu Arg Ser
1185                1190                1195                1200
Leu His His Ala Thr Leu His Phe Arg Ser Asn Glu Glu Glu Glu Gly
                1205                1210                1215
Val Cys Cys Gly Arg Phe Thr Gly Cys Ser Leu Ser Gln Glu His Val
            1220                1225                1230
Glu Ser Leu Cys Trp Leu Leu Ser Lys Cys Lys Asp Leu Ser Gln Val
        1235                1240                1245
Asp Leu Ser Ala Asn Leu Leu Gly Asp Ser Gly Leu Arg Cys Leu Leu
    1250                1255                1260
Glu Cys Leu Pro Gln Val Pro Ile Ser Gly Leu Leu Asp Leu Ser His
1265                1270                1275                1280
Asn Ser Ile Ser Gln Glu Ser Ala Leu Tyr Leu Leu Glu Thr Leu Pro
                1285                1290                1295
Ser Cys Pro Arg Val Arg Glu Ala Ser Val Asn Leu Gly Ser Glu Gln
            1300                1305                1310
Ser Phe Arg Ile His Phe Ser Arg Glu Asp Gln Ala Gly Lys Thr Leu
        1315                1320                1325
Arg Leu Ser Glu Cys Ser Phe Arg Pro Glu His Val Ser Arg Leu Ala
    1330                1335                1340
Thr Gly Leu Ser Lys Ser Leu Gln Leu Thr Glu Leu Thr Leu Thr Gln
1345                1350                1355                1360
Cys Cys Leu Gly Gln Lys Gln Leu Ala Ile Leu Leu Ser Leu Val Gly
                1365                1370                1375
Arg Pro Ala Gly Leu Phe Ser Leu Arg Val Gln Glu Pro Trp Ala Asp
            1380                1385                1390
Arg Ala Arg Val Leu Ser Leu Leu Glu Val Cys Ala Gln Ala Ser Gly
        1395                1400                1405
Ser Val Thr Glu Ile Ser Ile Ser Glu Thr Gln Gln Gln Leu Cys Val
    1410                1415                1420
Gln Leu Glu Phe Pro Arg Gln Glu Glu Asn Pro Glu Ala Val Ala Leu
1425                1430                1435                1440
Arg Leu Ala His Cys Asp Leu Gly Ala His His Ser Leu Leu Val Gly
                1445                1450                1455
Gln Leu Met Glu Thr Cys Ala Arg Leu Gln Gln Leu Ser Leu Ser Gln
            1460                1465                1470
Val Asn Leu Cys Glu Asp Asp Asp Ala Ser Ser Leu Leu Leu Gln Ser
        1475                1480                1485
Leu Leu Leu Ser Leu Ser Glu Leu Lys Thr Phe Arg Leu Thr Ser Ser
    1490                1495                1500
Cys Val Ser Thr Glu Gly Leu Ala His Leu Ala Ser Gly Leu Gly His
1505                1510                1515                1520
Cys His His Leu Glu Glu Leu Asp Leu Ser Asn Asn Gln Phe Asp Glu
                1525                1530                1535
Glu Gly Thr Lys Ala Leu Met Arg Ala Leu Glu Gly Lys Trp Met Leu
            1540                1545                1550
Lys Arg Leu Asp Leu Ser His Leu Leu Leu Asn Ser Ser Thr Leu Ala
        1555                1560                1565
Leu Leu Thr His Arg Leu Ser Gln Met Thr Cys Leu Gln Ser Leu Arg
    1570                1575                1580
Leu Asn Arg Asn Ser Ile Gly Asp Val Gly Cys Cys His Leu Ser Glu
1585                1590                1595                1600
Ala Leu Arg Ala Ala Thr Ser Leu Glu Glu Leu Asp Leu Ser His Asn
                1605                1610                1615
Gln Ile Gly Asp Ala Gly Val Gln His Leu Ala Thr Ile Leu Pro Gly
            1620                1625                1630
Leu Pro Glu Leu Arg Lys Ile Asp Leu Ser Gly Asn Ser Ile Ser Ser
        1635                1640                1645
Ala Gly Gly Val Gln Leu Ala Glu Ser Leu Val Leu Cys Arg Arg Leu
    1650                1655                1660
Glu Glu Leu Met Leu Gly Cys Asn Ala Leu Gly Asp Pro Thr Ala Leu
1665                1670                1675                1680
Gly Leu Ala Gln Glu Leu Pro Gln His Leu Arg Val Leu His Leu Pro
                1685                1690                1695
Phe Ser His Leu Gly Pro Gly Gly Ala Leu Ser Leu Ala Gln Ala Leu
            1700                1705                1710
Asp Gly Ser Pro His Leu Glu Glu Ile Ser Leu Ala Glu Asn Asn Leu
        1715                1720                1725
Ala Gly Gly Val Leu Arg Phe Cys Met Glu Leu Pro Leu Leu Arg Gln
    1730                1735                1740
Ile Asp Leu Val Ser Cys Lys Ile Asp Asn Gln Thr Ala Lys Leu Leu
1745                1750                1755                1760
Thr Ser Ser Phe Thr Ser Cys Pro Ala Leu Glu Val Ile Leu Leu Ser
                1765                1770                1775
Trp Asn Leu Leu Gly Asp Glu Ala Ala Ala Glu Leu Ala Gln Val Leu
            1780                1785                1790
Pro Gln Met Gly Arg Leu Lys Arg Val Asp Leu Glu Lys Asn Gln Ile
        1795                1800                1805
Thr Ala Leu Gly Ala Trp Leu Leu Ala Glu Gly Leu Ala Gln Gly Ser
    1810                1815                1820
Ser Ile Gln Val Ile Arg Leu Trp Asn Asn Pro Ile Pro Cys Asp Met
1825                1830                1835                1840
Ala Gln His Leu Lys Ser Gln Glu Pro Arg Leu Asp Phe Ala Phe Phe
                1845                1850                1855
Asp Asn Gln Pro Gln Ala Pro Trp Gly Thr
            1860                1865

<210> 63
<211> 426
<212> PRT
<213> Homo sapiens

<400> 63
Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu
 1               5                  10                  15
Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu
            20                  25                  30
Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr
        35                  40                  45
Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys
    50                  55                  60
Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr
65                  70                  75                  80
Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr
                85                  90                  95
Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile
            100                 105                 110
Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly
        115                 120                 125
Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp
    130                 135                 140
Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile Lys
145                 150                 155                 160
Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp
                165                 170                 175
Trp Trp Ala Gln Gln Pro Ser Thr Gly Val Pro Leu Val Thr Gly Tyr
            180                 185                 190
Thr Thr Tyr Asp Ala His His Ser Ala Phe Ser Gln Met Val Ile Ser
        195                 200                 205
Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Pro
    210                 215                 220
Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys
225                 230                 235                 240
Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe Pro Pro Ala Asp
                245                 250                 255
Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly
            260                 265                 270
His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg Gln Gly Val Phe
        275                 280                 285
Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val
    290                 295                 300
Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln
305                 310                 315                 320
Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln Gln Phe Tyr Asn
                325                 330                 335
Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu Cys Phe Gly Glu
            340                 345                 350
Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu Ile Leu Val Gln
        355                 360                 365
Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu Ala Gly Lys Ser
    370                 375                 380
Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu Pro Pro Pro Asp
385                 390                 395                 400
Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser His Gln Arg Ser
                405                 410                 415
Phe Phe Arg Glu Asn Gln Gln Ile Thr Val
            420                 425

<210> 64
<211> 99
<212> PRT
<213> Homo sapiens

<400> 64
Met Ala Ala Ala Ala Ala Ser Arg Gly Val Gly Ala Lys Leu Gly Leu
 1               5                  10                  15
Arg Glu Ile Arg Ile His Leu Cys Gln Arg Ser Pro Gly Ser Gln Gly
            20                  25                  30
Val Arg Asp Phe Ile Glu Lys Arg Tyr Val Glu Leu Lys Lys Ala Asn
        35                  40                  45
Pro Asp Leu Pro Ile Leu Ile Arg Glu Cys Ser Asp Val Gln Pro Lys
    50                  55                  60
Leu Trp Ala Arg Tyr Ala Phe Gly Gln Glu Thr Asn Val Pro Leu Asn
65                  70                  75                  80
Asn Phe Ser Ala Asp Gln Val Thr Arg Ala Leu Glu Asn Val Leu Ser
                85                  90                  95
Gly Lys Ala


<210> 65
<211> 464
<212> PRT
<213> Homo sapiens

<400> 65
Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val
 1               5                  10                  15
Ser Val Arg Phe Ser Gly Asp Thr Thr Ala Pro Lys Lys Thr Ser Phe
            20                  25                  30
Gly Ser Leu Lys Asp Glu Asp Arg Ile Phe Thr Asn Leu Tyr Gly Arg
        35                  40                  45
His Asp Trp Arg Leu Lys Gly Ser Leu Ser Arg Gly Asp Trp Tyr Lys
    50                  55                  60
Thr Lys Glu Ile Leu Leu Lys Gly Pro Asp Trp Ile Leu Gly Glu Ile
65                  70                  75                  80
Lys Thr Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly Phe Pro Thr Gly
                85                  90                  95
Leu Lys Trp Ser Phe Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr
            100                 105                 110
Leu Val Val Asn Ala Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg
        115                 120                 125
Glu Ile Leu Arg His Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val
    130                 135                 140
Gly Gly Arg Ala Met Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly
145                 150                 155                 160
Glu Phe Tyr Asn Glu Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala
                165                 170                 175
Tyr Glu Ala Gly Leu Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp
            180                 185                 190
Phe Asp Val Phe Val Val Arg Gly Ala Gly Ala Tyr Ile Cys Gly Glu
        195                 200                 205
Glu Thr Ala Leu Ile Glu Ser Ile Glu Gly Lys Gln Gly Lys Pro Arg
    210                 215                 220
Leu Lys Pro Pro Phe Pro Ala Asp Val Gly Val Phe Gly Cys Pro Thr
225                 230                 235                 240
Thr Val Ala Asn Val Glu Thr Val Ala Val Ser Pro Thr Ile Cys Arg
                245                 250                 255
Arg Gly Gly Thr Trp Phe Ala Gly Phe Gly Arg Glu Arg Asn Ser Gly
            260                 265                 270
Thr Lys Leu Phe Asn Ile Ser Gly His Val Asn His Pro Cys Thr Val
        275                 280                 285
Glu Glu Glu Met Ser Val Pro Leu Lys Glu Leu Ile Glu Lys His Ala
    290                 295                 300
Gly Gly Val Thr Gly Gly Trp Asp Asn Leu Leu Ala Val Ile Pro Gly
305                 310                 315                 320
Gly Ser Ser Thr Pro Leu Ile Pro Lys Ser Val Cys Glu Thr Val Leu
                325                 330                 335
Met Asp Phe Asp Ala Leu Val Gln Ala Gln Thr Gly Leu Gly Thr Ala
            340                 345                 350
Ala Val Ile Val Met Asp Arg Ser Thr Asp Ile Val Lys Ala Ile Ala
        355                 360                 365
Arg Leu Ile Glu Phe Tyr Lys His Glu Ser Cys Gly Gln Cys Thr Pro
    370                 375                 380
Cys Arg Glu Gly Val Asp Trp Met Asn Lys Val Met Ala Arg Phe Val
385                 390                 395                 400
Arg Gly Asp Ala Arg Pro Ala Glu Ile Asp Ser Leu Trp Glu Ile Ser
                405                 410                 415
Lys Gln Ile Glu Gly His Thr Ile Cys Ala Leu Gly Asp Gly Ala Ala
            420                 425                 430
Trp Pro Val Gln Gly Leu Ile Arg His Phe Arg Pro Glu Leu Glu Glu
        435                 440                 445
Arg Met Gln Arg Phe Ala Gln Gln His Gln Ala Arg Gln Ala Ala Ser
    450                 455                 460

<210> 66
<211> 144
<212> PRT
<213> Homo sapiens

<400> 66
Met Ala Ala Ser Lys Val Lys Gln Asp Met Pro Pro Pro Gly Gly Tyr
 1               5                  10                  15
Gly Pro Ile Asp Tyr Lys Arg Asn Leu Pro Arg Arg Gly Leu Ser Gly
            20                  25                  30
Tyr Ser Met Leu Ala Ile Gly Ile Gly Thr Leu Ile Tyr Gly His Trp
        35                  40                  45
Ser Ile Met Lys Trp Asn Arg Glu Arg Arg Arg Leu Gln Ile Glu Asp
    50                  55                  60
Phe Glu Ala Arg Ile Ala Leu Leu Pro Leu Leu Gln Ala Glu Thr Asp
65                  70                  75                  80
Arg Arg Thr Leu Gln Met Leu Arg Glu Asn Leu Glu Glu Glu Ala Ile
                85                  90                  95
Ile Met Lys Asp Val Pro Asp Trp Lys Val Gly Glu Ser Val Phe His
            100                 105                 110
Thr Thr Arg Trp Val Pro Pro Leu Ile Gly Glu Leu Tyr Gly Leu Arg
        115                 120                 125
Thr Thr Glu Glu Ala Leu His Ala Ser His Gly Phe Met Trp Tyr Thr
    130                 135                 140

<210> 67
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 67
Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln
 1               5                  10                  15
Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp
            20                  25                  30
Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu
        35                  40                  45
Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser
    50                  55                  60
Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg
65                  70                  75                  80
Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro
                85                  90                  95
Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln
            100                 105                 110
Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr
        115                 120                 125
Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg
    130                 135                 140
Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His
145                 150                 155                 160
Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val
                165                 170                 175
Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu
            180                 185                 190
Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys
        195                 200                 205
Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr
    210                 215                 220
Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys
225                 230                 235                 240
Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val
                245                 250                 255
Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys
            260                 265                 270
Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu
        275                 280                 285
Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu
    290                 295                 300
Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile
305                 310                 315                 320
Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu
                325                 330                 335
Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu
            340                 345                 350
Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val
        355                 360                 365
Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His
    370                 375                 380
Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro
385                 390                 395                 400
Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp
                405                 410                 415
Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro
            420                 425                 430
Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr
        435                 440                 445
Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His
    450                 455                 460
Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe
465                 470                 475                 480
Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His
                485                 490                 495
Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn
            500                 505                 510
Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu
        515                 520                 525
Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu
    530                 535                 540
Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu
545                 550                 555                 560
Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys
                565                 570                 575
Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr
            580                 585                 590
Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser
        595                 600                 605
Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro
    610                 615                 620
Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn
625                 630                 635                 640
Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn
                645                 650                 655
Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser
            660                 665                 670
Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe
        675                 680                 685
Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His
    690                 695                 700
Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met
705                 710                 715                 720
Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu
                725                 730                 735
Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser
            740                 745                 750
Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe
        755                 760                 765
Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys
    770                 775                 780
Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp
785                 790                 795                 800
Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg
                805                 810                 815
Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr
            820                 825                 830
Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly
        835                 840                 845
Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu
    850                 855                 860
Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln
865                 870                 875                 880
Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys
                885                 890                 895
Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro
            900                 905                 910
Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala
        915                 920                 925
Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile
    930                 935                 940
Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu
945                 950                 955                 960
Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro
                965                 970                 975
Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val
            980                 985                 990
Ala His Phe His Lys Glu Val Phe Gly Thr Phe Gly Ile Pro Phe Leu
        995                 1000                1005
Leu Arg Ile His Gln Gly Glu His Phe Arg Glu Val Met Lys Arg Ile
    1010                1015                1020
Gln Ser Leu Leu Asp Ile Gln Glu Lys Glu Phe Glu Lys Phe Lys Phe
1025                1030                1035                1040
Ala Ile Val Met Met Gly Arg His Gln Tyr Ile Asn Glu Asp Glu Tyr
                1045                1050                1055
Glu Val Asn Leu Lys Asp Phe Glu Pro Gln Pro Gly Asn Met Ser His
            1060                1065                1070
Pro Arg Pro Trp Leu Gly Leu Asp His Phe Asn Lys Ala Pro Lys Arg
        1075                1080                1085
Ser Arg Tyr Thr Tyr Leu Glu Lys Ala Ile Lys Ile His Asn
    1090                1095                1100

<210> 68
<211> 74
<212> PRT
<213> Homo sapiens

<400> 68
Met Ser Ala Asn Gly Ala Val Trp Gly Arg Val Arg Ser Arg Leu Arg
 1               5                  10                  15
Ala Phe Pro Glu Arg Leu Ala Ala Cys Gly Ala Glu Ala Ala Ala Tyr
            20                  25                  30
Gly Arg Cys Val Gln Ala Ser Thr Ala Pro Gly Gly Arg Leu Ser Lys
        35                  40                  45
Asp Phe Cys Ala Arg Glu Phe Glu Ala Leu Arg Ser Cys Phe Ala Ala
    50                  55                  60
Ala Ala Lys Lys Thr Leu Glu Gly Gly Cys
65                  70

<210> 69
<211> 272
<212> PRT
<213> Homo sapiens

<400> 69
Met Glu Ala Gln Gly Val Ala Glu Gly Ala Gly Pro Gly Ala Ala Ser
 1               5                  10                  15
Gly Val Pro His Pro Ala Ala Leu Ala Pro Ala Ala Ala Pro Thr Leu
            20                  25                  30
Ala Pro Ala Ser Val Ala Ala Ala Ala Ser Gln Phe Thr Leu Leu Val
        35                  40                  45
Met Gln Pro Cys Ala Gly Gln Asp Glu Ala Ala Ala Pro Gly Gly Ser
    50                  55                  60
Val Gly Ala Gly Lys Pro Val Arg Tyr Leu Cys Glu Gly Ala Gly Asp
65                  70                  75                  80
Gly Glu Glu Glu Ala Gly Glu Asp Glu Ala Asp Leu Leu Asp Thr Ser
                85                  90                  95
Asp Pro Pro Gly Gly Gly Glu Ser Ala Ala Ser Leu Glu Asp Leu Glu
            100                 105                 110
Asp Glu Glu Thr His Ser Gly Gly Glu Gly Ser Ser Gly Gly Ala Arg
        115                 120                 125
Arg Arg Gly Ser Gly Gly Gly Ser Met Ser Lys Thr Cys Thr Tyr Glu
    130                 135                 140
Gly Cys Ser Glu Thr Thr Ser Gln Val Ala Lys Gln Arg Lys Pro Trp
145                 150                 155                 160
Met Cys Lys Lys His Arg Asn Lys Met Tyr Lys Asp Lys Tyr Lys Lys
                165                 170                 175
Lys Lys Ser Asp Gln Ala Leu Asn Cys Gly Gly Thr Ala Ser Thr Gly
            180                 185                 190
Ser Ala Gly Asn Val Lys Leu Glu Glu Ser Ala Asp Asn Ile Leu Ser
        195                 200                 205
Ile Val Lys Gln Arg Thr Gly Ser Phe Gly Asp Arg Pro Ala Arg Pro
    210                 215                 220
Thr Leu Leu Glu Gln Val Leu Asn Gln Lys Arg Leu Ser Leu Leu Arg
225                 230                 235                 240
Ser Pro Glu Val Val Gln Phe Leu Gln Lys Gln Gln Gln Leu Leu Asn
                245                 250                 255
Gln Gln Val Leu Glu Gln Arg Gln Gln Gln Phe Pro Gly Thr Ser Met
            260                 265                 270

<210> 70
<211> 152
<212> PRT
<213> Homo sapiens

<400> 70
Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Leu
 1               5                  10                  15
Gln Glu Asp Pro Pro Ala Gly Val Ser Gly Ala Pro Ser Glu Asn Asn
            20                  25                  30
Ile Met Val Trp Asn Ala Val Ile Phe Gly Pro Glu Gly Thr Pro Phe
        35                  40                  45
Glu Asp Gly Thr Phe Lys Leu Thr Ile Glu Phe Thr Glu Glu Tyr Pro
    50                  55                  60
Asn Lys Pro Pro Thr Val Arg Phe Val Ser Lys Met Phe His Pro Asn
65                  70                  75                  80
Val Tyr Ala Asp Gly Ser Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp
                85                  90                  95
Ser Pro Thr Tyr Asp Val Ser Ser Ile Leu Thr Ser Ile Gln Ser Leu
            100                 105                 110
Leu Asp Glu Pro Asn Pro Asn Ser Pro Ala Asn Ser Gln Ala Ala Gln
        115                 120                 125
Leu Tyr Gln Glu Asn Lys Arg Glu Tyr Glu Lys Arg Val Ser Ala Ile
    130                 135                 140
Val Glu Gln Ser Trp Arg Asp Cys
145                 150

<210> 71
<211> 655
<212> PRT
<213> Homo sapiens

<400> 71
Met Glu Arg Lys Val Leu Ala Leu Gln Ala Arg Lys Lys Arg Thr Lys
 1               5                  10                  15
Ala Lys Lys Asp Lys Ala Gln Arg Lys Ser Glu Thr Gln His Arg Gly
            20                  25                  30
Ser Ala Pro His Ser Glu Ser Asp Leu Pro Glu Gln Glu Glu Glu Ile
        35                  40                  45
Leu Gly Ser Asp Asp Asp Glu Gln Glu Asp Pro Asn Asp Tyr Cys Lys
    50                  55                  60
Gly Gly Tyr His Leu Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr
65                  70                  75                  80
His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu
                85                  90                  95
Ser Trp Asp Ile Gln Gly Lys Lys Phe Val Ala Met Lys Val Val Lys
            100                 105                 110
Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Arg Leu Leu
        115                 120                 125
Lys Ser Val Arg Asn Ser Asp Pro Asn Asp Pro Asn Arg Glu Met Val
    130                 135                 140
Val Gln Leu Leu Asp Asp Phe Lys Ile Ser Gly Val Asn Gly Thr His
145                 150                 155                 160
Ile Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile
                165                 170                 175
Ile Lys Ser Asn Tyr Gln Gly Leu Pro Leu Pro Cys Val Lys Lys Ile
            180                 185                 190
Ile Gln Gln Val Leu Gln Gly Leu Asp Tyr Leu His Thr Lys Cys Arg
        195                 200                 205
Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu Ser Val Asn
    210                 215                 220
Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu Trp Gln Arg
225                 230                 235                 240
Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln
                245                 250                 255
Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys Lys Lys Lys Leu Lys
            260                 265                 270
Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Met Gln Glu
        275                 280                 285
Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly Gln Lys Arg Pro Asn
    290                 295                 300
Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg Pro Leu Lys Glu Asn
305                 310                 315                 320
Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu Glu Ser Ser Thr Ile
                325                 330                 335
Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr Glu Gly Gly Ala Ala
            340                 345                 350
Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile Asn Tyr Thr Gln Asn
        355                 360                 365
Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp Leu His Asn Ala Asn
    370                 375                 380
Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser Ser Phe Leu Ser Ser
385                 390                 395                 400
Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr Asp Ser Cys Thr Pro
                405                 410                 415
Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys Gln Ser Ser Ser Thr
            420                 425                 430
Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser Gln Leu Gln Glu Ser
        435                 440                 445
Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln Glu Gln Glu His Asn
    450                 455                 460
Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala Gly Asn Phe Leu Val
465                 470                 475                 480
Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu Lys Val Lys Ile Ala
                485                 490                 495
Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp Ile
            500                 505                 510
Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile Gly Ser Gly Tyr
        515                 520                 525
Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu Leu
    530                 535                 540
Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Glu Tyr Thr
545                 550                 555                 560
Arg Asp Glu Asp His Ile Ala Leu Ile Ile Glu Leu Leu Gly Lys Val
                565                 570                 575
Pro Arg Lys Leu Ile Val Ala Gly Lys Tyr Ser Lys Glu Phe Phe Thr
            580                 585                 590
Lys Lys Gly Asp Leu Lys His Ile Thr Lys Leu Lys Pro Trp Gly Leu
        595                 600                 605
Phe Glu Val Leu Val Glu Lys Tyr Glu Trp Ser Gln Glu Glu Ala Ala
    610                 615                 620
Gly Phe Thr Asp Phe Leu Leu Pro Met Leu Glu Leu Ile Pro Glu Lys
625                 630                 635                 640
Arg Ala Thr Ala Ala Glu Cys Leu Arg His Pro Trp Leu Asn Ser
                645                 650                 655

<210> 72
<211> 213
<212> PRT
<213> Homo sapiens

<400> 72
Met Ala Val Leu Ser Ala Pro Gly Leu Arg Gly Phe Arg Ile Leu Gly
 1               5                  10                  15
Leu Arg Ser Ser Val Gly Pro Ala Val Gln Ala Arg Gly Val His Gln
            20                  25                  30
Ser Val Ala Thr Asp Gly Pro Ser Ser Thr Gln Pro Ala Leu Pro Lys
        35                  40                  45
Ala Arg Ala Val Ala Pro Lys Pro Ser Ser Arg Gly Glu Tyr Val Val
    50                  55                  60
Ala Lys Leu Asp Asp Leu Val Asn Trp Ala Arg Arg Ser Ser Leu Trp
65                  70                  75                  80
Pro Met Thr Phe Gly Leu Ala Cys Cys Ala Val Glu Met Met His Met
                85                  90                  95
Ala Ala Pro Arg Tyr Asp Met Asp Arg Phe Gly Val Val Phe Arg Ala
            100                 105                 110
Ser Pro Arg Gln Ser Asp Val Met Ile Val Ala Gly Thr Leu Thr Asn
        115                 120                 125
Lys Met Ala Pro Ala Leu Arg Lys Val Tyr Asp Gln Met Pro Glu Pro
    130                 135                 140
Arg Tyr Val Val Ser Met Gly Ser Cys Ala Asn Gly Gly Gly Tyr Tyr
145                 150                 155                 160
His Tyr Ser Tyr Ser Val Val Arg Gly Cys Asp Arg Ile Val Pro Val
                165                 170                 175
Asp Ile Tyr Ile Pro Gly Cys Pro Pro Thr Ala Glu Ala Leu Leu Tyr
            180                 185                 190
Gly Ile Leu Gln Leu Gln Arg Lys Ile Lys Arg Glu Arg Arg Leu Gln
        195                 200                 205
Ile Trp Tyr Arg Arg
    210

<210> 73
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 73
Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro
 1               5                  10                  15
Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val
            20                  25                  30
Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp
        35                  40                  45
Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala
    50                  55                  60
Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val
65                  70                  75                  80
Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro
                85                  90                  95
Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg
            100                 105                 110
Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr
        115                 120                 125
Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys
    130                 135                 140
Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr
145                 150                 155                 160
Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His
                165                 170                 175
Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser
            180                 185                 190
Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys
        195                 200                 205
Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg
    210                 215                 220
Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val
225                 230                 235                 240
Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Phe
                245                 250                 255
Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser
            260                 265                 270
Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu
        275                 280                 285
Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp
    290                 295                 300
Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly
305                 310                 315                 320
Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe
                325                 330                 335
Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr
            340                 345                 350
Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His
        355                 360                 365
Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu
    370                 375                 380
Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg Thr Leu Asp Lys
385                 390                 395                 400
Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr
                405                 410                 415
Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln
            420                 425                 430
Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser
        435                 440                 445
Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val
    450                 455                 460
Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu
465                 470                 475                 480
Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp
                485                 490                 495
Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu
            500                 505                 510
Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys
        515                 520                 525
Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp
    530                 535                 540
Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg
545                 550                 555                 560
Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala
                565                 570                 575
Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln
            580                 585                 590
Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile
        595                 600                 605
Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln
    610                 615                 620
Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val
625                 630                 635                 640
Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu
                645                 650                 655
Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser
            660                 665                 670
Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala
        675                 680                 685
Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro
    690                 695                 700
His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys
705                 710                 715                 720
Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile
                725                 730                 735
Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His
            740                 745                 750
Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val
        755                 760                 765
Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro
    770                 775                 780
Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn
785                 790                 795                 800
Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu
                805                 810                 815
Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met
            820                 825                 830
Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr
        835                 840                 845
Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu
    850                 855                 860
Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu
865                 870                 875                 880
Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His
                885                 890                 895
Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn
            900                 905                 910
Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys
        915                 920                 925
Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala
    930                 935                 940
Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln
945                 950                 955                 960
Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His
                965                 970                 975
Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val
            980                 985                 990
Pro Tyr Thr Ile His Leu Leu Ala His Asp Pro Asp Tyr Val Lys Val
        995                 1000                1005
Gln Asp Ile Glu Gln Leu Lys Asp Val Lys Glu Cys Leu Trp Phe Val
    1010                1015                1020
Leu Glu Ile Leu Met Ala Lys Asn Glu Asn Asn Ser His Ala Phe Ile
1025                1030                1035                1040
Arg Lys Met Val Glu Asn Ile Lys Gln Thr Lys Asp Ala Gln Gly Pro
                1045                1050                1055
Asp Asp Ala Lys Met Asn Glu Lys Leu Tyr Thr Val Cys Asp Val Ala
            1060                1065                1070
Met Asn Ile Ile Met Ser Lys Ser Thr Thr Tyr Ser Leu Glu Ser Pro
        1075                1080                1085
Lys Asp Pro Val Leu Pro Ala Arg Phe Phe Thr Gln Pro Asp Lys Asn
    1090                1095                1100
Phe Ser Asn Thr Lys Asn Tyr Leu Pro Pro Glu Met Lys Ser Phe Phe
1105                1110                1115                1120
Thr Pro Gly Lys Pro Lys Thr Thr Asn Val Leu Gly Ala Val Asn Lys
                1125                1130                1135
Pro Leu Ser Ser Ala Gly Lys Gln Ser Gln Thr Lys Ser Ser Arg Met
            1140                1145                1150
Glu Thr Val Ser Asn Ala Ser Ser Ser Ser Asn Pro Ser Ser Pro Gly
        1155                1160                1165
Arg Ile Lys Gly Arg Leu Asp Ser Ser Glu Met Asp His Ser Glu Asn
    1170                1175                1180
Glu Asp Tyr Thr Met Ser Ser Pro Leu Pro Gly Lys Lys Ser Asp Lys
1185                1190                1195                1200
Arg Asp Asp Ser Asp Leu Val Arg Ser Glu Leu Glu Lys Pro Arg Gly
                1205                1210                1215
Arg Lys Lys Thr Pro Val Thr Glu Gln Glu Glu Lys Leu Gly Met Asp
            1220                1225                1230
Asp Leu Thr Lys Leu Val Gln Glu Gln Lys Pro Lys Gly Ser Gln Arg
        1235                1240                1245
Ser Arg Lys Arg Gly His Thr Ala Ser Glu Ser Asp Glu Gln Gln Trp
    1250                1255                1260
Pro Glu Glu Lys Arg Leu Lys Glu Asp Ile Leu Glu Asn Glu Asp Glu
1265                1270                1275                1280
Gln Asn Ser Pro Pro Lys Lys Gly Lys Arg Gly Arg Pro Pro Lys Pro
                1285                1290                1295
Leu Gly Gly Gly Thr Pro Lys Glu Glu Pro Thr Met Lys Thr Ser Lys
            1300                1305                1310
Lys Gly Ser Lys Lys Lys Ser Gly Pro Pro Ala Pro Glu Glu Glu Glu
        1315                1320                1325
Glu Glu Glu Arg Gln Ser Gly Asn Thr Glu Gln Lys Ser Lys Ser Lys
    1330                1335                1340
Gln His Arg Val Ser Arg Arg Ala Gln Gln Arg Ala Glu Ser Pro Glu
1345                1350                1355                1360
Ser Ser Ala Ile Glu Ser Thr Gln Ser Thr Pro Gln Lys Gly Arg Gly
                1365                1370                1375
Arg Pro Ser Lys Thr Pro Ser Pro Ser Gln Pro Lys Lys Asn Val Arg
            1380                1385                1390
Val Gly Arg Ser Lys Gln Ala Ala Thr Lys Glu Asn Asp Ser Ser Glu
        1395                1400                1405
Glu Val Asp Val Phe Gln Gly Ser Ser Pro Val Asp Asp Ile Pro Gln
    1410                1415                1420
Glu Glu Thr Glu Glu Glu Glu Val Ser Thr Val Asn Val Arg Arg Arg
1425                1430                1435                1440
Ser Ala Lys Arg Glu Arg Arg
                1445

<210> 74
<211> 510
<212> PRT
<213> Homo sapiens

<400> 74
Met Pro Gly Gly Gly Ala Ser Ala Ala Ser Gly Arg Leu Leu Thr Ala
 1               5                  10                  15
Ala Glu Gln Arg Gly Ser Arg Glu Ala Ala Gly Ser Ala Ser Arg Ser
            20                  25                  30
Gly Phe Gly Gly Ser Gly Gly Gly Arg Gly Gly Ala Ser Gly Pro Gly
        35                  40                  45
Ser Gly Ser Gly Gly Pro Gly Gly Pro Ala Gly Arg Met Ser Leu Thr
    50                  55                  60
Pro Lys Glu Leu Ser Ser Leu Leu Ser Ile Ile Ser Glu Glu Ala Gly
65                  70                  75                  80
Gly Gly Ser Thr Phe Glu Gly Leu Ser Thr Ala Phe His His Tyr Phe
                85                  90                  95
Ser Lys Ala Asp His Phe Arg Leu Gly Ser Val Leu Val Met Leu Leu
            100                 105                 110
Gln Gln Pro Asp Leu Leu Pro Ser Ala Ala Gln Arg Leu Thr Ala Leu
        115                 120                 125
Tyr Leu Leu Trp Glu Met Tyr Arg Thr Glu Pro Leu Ala Ala Asn Pro
    130                 135                 140
Phe Ala Ala Ser Phe Ala His Leu Leu Asn Pro Ala Pro Pro Ala Arg
145                 150                 155                 160
Gly Gly Gln Glu Pro Asp Arg Pro Pro Leu Ser Gly Phe Leu Pro Pro
                165                 170                 175
Ile Thr Pro Pro Glu Lys Phe Phe Leu Ser Gln Leu Met Leu Ala Pro
            180                 185                 190
Pro Arg Glu Leu Phe Lys Lys Thr Pro Arg Gln Ile Ala Leu Met Asp
        195                 200                 205
Val Gly Asn Met Gly Gln Ser Val Asp Ile Ser Gly Leu Gln Leu Ala
    210                 215                 220
Leu Ala Glu Arg Gln Ser Glu Leu Pro Thr Gln Ser Lys Ala Ser Phe
225                 230                 235                 240
Pro Ser Ile Leu Ser Asp Pro Asp Pro Asp Ser Ser Asn Ser Gly Phe
                245                 250                 255
Asp Ser Ser Val Ala Ser Gln Ile Thr Glu Ala Leu Val Ser Gly Pro
            260                 265                 270
Lys Pro Pro Ile Glu Ser His Phe Arg Pro Glu Phe Ile Arg Pro Pro
        275                 280                 285
Pro Pro Leu His Ile Cys Glu Asp Glu Leu Ala Trp Leu Asn Pro Thr
    290                 295                 300
Glu Pro Asp His Ala Ile Gln Trp Asp Lys Ser Met Cys Val Lys Asn
305                 310                 315                 320
Ser Thr Gly Val Glu Ile Lys Arg Ile Met Ala Lys Ala Phe Lys Ser
                325                 330                 335
Pro Leu Ser Ser Pro Gln Gln Thr Gln Leu Leu Gly Glu Leu Glu Lys
            340                 345                 350
Asp Pro Lys Leu Val Tyr His Ile Gly Leu Thr Pro Ala Lys Leu Pro
        355                 360                 365
Asp Leu Val Glu Asn Asn Pro Leu Val Ala Ile Glu Met Leu Leu Lys
    370                 375                 380
Leu Met Gln Ser Ser Gln Ile Thr Glu Tyr Phe Ser Val Leu Val Asn
385                 390                 395                 400
Met Asp Met Ser Leu His Ser Met Glu Val Val Asn Arg Leu Thr Thr
                405                 410                 415
Ala Val Asp Leu Pro Pro Glu Phe Ile His Leu Tyr Ile Ser Asn Cys
            420                 425                 430
Ile Ser Thr Cys Glu Gln Ile Lys Asp Lys Tyr Met Gln Asn Arg Leu
        435                 440                 445
Val Arg Leu Val Cys Val Phe Leu Gln Ser Leu Ile Arg Asn Lys Ile
    450                 455                 460
Ile Asn Val Gln Asp Leu Phe Ile Glu Val Gln Ala Phe Cys Ile Glu
465                 470                 475                 480
Phe Ser Arg Ile Arg Glu Ala Ala Gly Leu Phe Arg Leu Leu Lys Thr
                485                 490                 495
Leu Asp Thr Gly Glu Thr Pro Ser Glu Thr Lys Met Ser Lys
            500                 505                 510

<210> 75
<211> 137
<212> PRT
<213> Homo sapiens

<400> 75
Met Gly Ala His Leu Val Arg Arg Tyr Leu Gly Asp Ala Ser Val Glu
 1               5                  10                  15
Pro Asp Pro Leu Gln Met Pro Thr Phe Pro Pro Asp Tyr Gly Phe Pro
            20                  25                  30
Glu Arg Lys Glu Arg Glu Met Val Ala Thr Gln Gln Glu Met Met Asp
        35                  40                  45
Ala Gln Leu Arg Leu Gln Leu Arg Asp Tyr Cys Ala His His Leu Ile
    50                  55                  60
Arg Leu Leu Lys Cys Lys Arg Asp Ser Phe Pro Asn Phe Leu Ala Cys
65                  70                  75                  80
Lys Gln Glu Arg His Asp Trp Asp Tyr Cys Glu His Arg Asp Tyr Val
                85                  90                  95
Met Arg Met Lys Glu Phe Glu Arg Glu Arg Arg Leu Leu Gln Arg Lys
            100                 105                 110
Lys Arg Arg Glu Lys Lys Ala Ala Glu Leu Ala Lys Gly Gln Gly Pro
        115                 120                 125
Gly Glu Val Asp Pro Lys Val Ala Leu
    130                 135

<210> 76
<211> 334
<212> PRT
<213> Homo sapiens

<400> 76
Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val
 1               5                  10                  15
Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser
            20                  25                  30
Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala
        35                  40                  45
Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu
    50                  55                  60
Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala
65                  70                  75                  80
Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg
                85                  90                  95
Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg
            100                 105                 110
Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe
        115                 120                 125
Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala
    130                 135                 140
Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly
145                 150                 155                 160
Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln
                165                 170                 175
Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala
            180                 185                 190
Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val
        195                 200                 205
Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn
    210                 215                 220
Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro
225                 230                 235                 240
Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu
                245                 250                 255
Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg
            260                 265                 270
Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln
        275                 280                 285
Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu
    290                 295                 300
Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu
305                 310                 315                 320
Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala
                325                 330

<210> 77
<211> 486
<212> PRT
<213> Homo sapiens

<400> 77
Met Ile Arg Arg Val Leu Pro His Gly Met Gly Arg Gly Leu Leu Thr
 1               5                  10                  15
Arg Arg Pro Gly Thr Arg Arg Gly Gly Phe Ser Leu Asp Trp Asp Gly
            20                  25                  30
Lys Val Ser Glu Ile Lys Lys Lys Ile Lys Ser Ile Leu Pro Gly Arg
        35                  40                  45
Ser Cys Asp Leu Leu Gln Asp Thr Ser His Leu Pro Pro Glu His Ser
    50                  55                  60
Asp Val Val Ile Val Gly Gly Gly Val Leu Gly Leu Ser Val Ala Tyr
65                  70                  75                  80
Trp Leu Lys Lys Leu Glu Ser Arg Arg Gly Ala Ile Arg Val Leu Val
                85                  90                  95
Val Glu Arg Asp His Thr Tyr Ser Gln Ala Ser Thr Gly Leu Ser Val
            100                 105                 110
Gly Gly Ile Cys Gln Gln Phe Ser Leu Pro Glu Asn Ile Gln Leu Ser
        115                 120                 125
Leu Phe Ser Ala Ser Phe Leu Arg Asn Ile Asn Glu Tyr Leu Ala Val
    130                 135                 140
Val Asp Ala Pro Pro Leu Asp Leu Arg Phe Asn Pro Ser Gly Tyr Leu
145                 150                 155                 160
Leu Leu Ala Ser Glu Lys Asp Ala Ala Ala Met Glu Ser Asn Val Lys
                165                 170                 175
Val Gln Arg Gln Glu Gly Ala Lys Val Ser Leu Met Ser Pro Asp Gln
            180                 185                 190
Leu Arg Asn Lys Phe Pro Trp Ile Asn Thr Glu Gly Val Ala Leu Ala
        195                 200                 205
Ser Tyr Gly Met Glu Asp Glu Gly Trp Phe Asp Pro Trp Cys Leu Leu
    210                 215                 220
Gln Gly Leu Arg Arg Lys Val Gln Ser Leu Gly Val Leu Phe Cys Gln
225                 230                 235                 240
Gly Glu Val Thr Arg Phe Val Ser Ser Ser Gln Arg Met Leu Thr Thr
                245                 250                 255
Asp Asp Lys Ala Val Val Leu Lys Arg Ile His Glu Val His Val Lys
            260                 265                 270
Met Asp Arg Ser Leu Glu Tyr Gln Pro Val Glu Cys Ala Ile Val Ile
        275                 280                 285
Asn Ala Ala Gly Ala Trp Ser Ala Gln Ile Ala Ala Leu Ala Gly Val
    290                 295                 300
Gly Glu Gly Pro Pro Gly Thr Leu Gln Gly Thr Lys Leu Pro Val Glu
305                 310                 315                 320
Pro Arg Lys Arg Tyr Val Tyr Val Trp His Cys Pro Gln Gly Pro Gly
                325                 330                 335
Leu Glu Thr Pro Leu Val Ala Asp Thr Ser Gly Ala Tyr Phe Arg Arg
            340                 345                 350
Glu Gly Leu Gly Ser Asn Tyr Leu Gly Gly Arg Ser Pro Thr Glu Gln
        355                 360                 365
Glu Glu Pro Asp Pro Ala Asn Leu Glu Val Asp His Asp Phe Phe Gln
    370                 375                 380
Asp Lys Val Trp Pro His Leu Ala Leu Arg Val Pro Ala Phe Glu Thr
385                 390                 395                 400
Leu Lys Val Gln Ser Ala Trp Ala Gly Tyr Tyr Asp Tyr Asn Thr Phe
                405                 410                 415
Asp Gln Asn Gly Val Val Gly Pro His Pro Leu Val Val Asn Met Tyr
            420                 425                 430
Phe Ala Thr Gly Phe Ser Gly His Gly Leu Gln Gln Ala Pro Gly Ile
        435                 440                 445
Gly Arg Ala Val Ala Glu Met Val Leu Lys Gly Arg Phe Gln Thr Ile
    450                 455                 460
Asp Leu Ser Pro Phe Leu Phe Thr Arg Phe Tyr Leu Gly Glu Lys Ile
465                 470                 475                 480
Gln Glu Asn Asn Ile Ile
                485

<210> 78
<211> 210
<212> PRT
<213> Homo sapiens

<400> 78
Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala
 1               5                  10                  15
Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val
            20                  25                  30
Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met
        35                  40                  45
Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu
    50                  55                  60
Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala
65                  70                  75                  80
Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg
                85                  90                  95
Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile
            100                 105                 110
Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile
        115                 120                 125
Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp
    130                 135                 140
Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys
145                 150                 155                 160
Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu
                165                 170                 175
Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly
            180                 185                 190
Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu
        195                 200                 205
Tyr Arg
    210

<210> 79
<211> 403
<212> PRT
<213> Homo sapiens

<400> 79
Met Asn His Lys Ser Lys Lys Arg Ile Arg Glu Ala Lys Arg Ser Ala
 1               5                  10                  15
Arg Pro Glu Leu Lys Asp Ser Leu Asp Trp Thr Arg His Asn Tyr Tyr
            20                  25                  30
Glu Ser Phe Ser Leu Ser Pro Ala Ala Val Ala Asp Asn Val Glu Arg
        35                  40                  45
Ala Asp Ala Leu Gln Leu Ser Val Glu Glu Phe Val Glu Arg Tyr Glu
    50                  55                  60
Arg Pro Tyr Lys Pro Val Val Leu Leu Asn Ala Gln Glu Gly Trp Ser
65                  70                  75                  80
Ala Gln Glu Lys Trp Thr Leu Glu Arg Leu Lys Arg Lys Tyr Arg Asn
                85                  90                  95
Gln Lys Phe Lys Cys Gly Glu Asp Asn Asp Gly Tyr Ser Val Lys Met
            100                 105                 110
Lys Met Lys Tyr Tyr Ile Glu Tyr Met Glu Ser Thr Arg Asp Asp Ser
        115                 120                 125
Pro Leu Tyr Ile Phe Asp Ser Ser Tyr Gly Glu His Pro Lys Arg Arg
    130                 135                 140
Lys Leu Leu Glu Asp Tyr Lys Val Pro Lys Phe Phe Thr Asp Asp Leu
145                 150                 155                 160
Phe Gln Tyr Ala Gly Glu Lys Arg Arg Pro Pro Tyr Arg Trp Phe Val
                165                 170                 175
Met Gly Pro Pro Arg Ser Gly Thr Gly Ile His Ile Asp Pro Leu Gly
            180                 185                 190
Thr Ser Ala Trp Asn Ala Leu Val Gln Gly His Lys Arg Trp Cys Leu
        195                 200                 205
Phe Pro Thr Ser Thr Pro Arg Glu Leu Ile Lys Val Thr Arg Asp Glu
    210                 215                 220
Gly Gly Asn Gln Gln Asp Glu Ala Ile Thr Trp Phe Asn Val Ile Tyr
225                 230                 235                 240
Pro Arg Thr Gln Leu Pro Thr Trp Pro Pro Glu Phe Lys Pro Leu Glu
                245                 250                 255
Ile Leu Gln Lys Pro Gly Glu Thr Val Phe Val Pro Gly Gly Trp Trp
            260                 265                 270
His Val Val Leu Asn Leu Asp Thr Thr Ile Ala Ile Thr Gln Asn Phe
        275                 280                 285
Ala Ser Ser Thr Asn Phe Pro Val Val Trp His Lys Thr Val Arg Gly
    290                 295                 300
Arg Pro Lys Leu Ser Arg Lys Trp Tyr Arg Ile Leu Lys Gln Glu His
305                 310                 315                 320
Pro Glu Leu Ala Val Leu Ala Asp Ser Val Asp Leu Gln Glu Ser Thr
                325                 330                 335
Gly Ile Ala Ser Asp Ser Ser Ser Asp Ser Ser Ser Ser Ser Ser Ser
            340                 345                 350
Ser Ser Ser Asp Ser Asp Ser Glu Cys Glu Ser Gly Ser Glu Gly Asp
        355                 360                 365
Gly Thr Val His Arg Arg Lys Lys Arg Arg Thr Cys Ser Met Val Gly
    370                 375                 380
Asn Gly Asp Thr Thr Ser Gln Asp Asp Cys Val Ser Lys Glu Arg Ser
385                 390                 395                 400
Ser Ser Arg


<210> 80
<211> 463
<212> PRT
<213> Homo sapiens

<400> 80
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460

<210> 81
<211> 119
<212> PRT
<213> Homo sapiens

<400> 81
Met Ile Ala Arg Arg Asn Pro Glu Pro Leu Arg Phe Leu Pro Asp Glu
 1               5                  10                  15
Ala Arg Ser Leu Pro Pro Pro Lys Leu Thr Asp Pro Arg Leu Leu Tyr
            20                  25                  30
Ile Gly Phe Leu Gly Tyr Cys Ser Gly Leu Ile Asp Asn Leu Ile Arg
        35                  40                  45
Arg Arg Pro Ile Ala Thr Ala Gly Leu His Arg Gln Leu Leu Tyr Ile
    50                  55                  60
Thr Ala Phe Phe Phe Ala Gly Tyr Tyr Leu Val Lys Arg Glu Asp Tyr
65                  70                  75                  80
Leu Tyr Ala Val Arg Asp Arg Glu Met Phe Gly Tyr Met Lys Leu His
                85                  90                  95
Pro Glu Asp Phe Pro Glu Glu Asp Lys Lys Thr Tyr Gly Glu Ile Phe
            100                 105                 110
Glu Lys Phe His Pro Ile Arg
        115

<210> 82
<211> 529
<212> PRT
<213> Homo sapiens

<400> 82
Met Asp Leu Pro Val Gly Pro Gly Ala Ala Gly Pro Ser Asn Val Pro
 1               5                  10                  15
Ala Phe Leu Thr Lys Leu Trp Thr Leu Val Ser Asp Pro Asp Thr Asp
            20                  25                  30
Ala Leu Ile Cys Trp Ser Pro Ser Gly Asn Ser Phe His Val Phe Asp
        35                  40                  45
Gln Gly Gln Phe Ala Lys Glu Val Leu Pro Lys Tyr Phe Lys His Asn
    50                  55                  60
Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe Arg Lys
65                  70                  75                  80
Val Val His Ile Glu Gln Gly Gly Leu Val Lys Pro Glu Arg Asp Asp
                85                  90                  95
Thr Glu Phe Gln His Pro Cys Phe Leu Arg Gly Gln Glu Gln Leu Leu
            100                 105                 110
Glu Asn Ile Lys Arg Lys Val Thr Ser Val Ser Thr Leu Lys Ser Glu
        115                 120                 125
Asp Ile Lys Ile Arg Gln Asp Ser Val Thr Lys Leu Leu Thr Asp Val
    130                 135                 140
Gln Leu Met Lys Gly Lys Gln Glu Cys Met Asp Ser Lys Leu Leu Ala
145                 150                 155                 160
Met Lys His Glu Asn Glu Ala Leu Trp Arg Glu Val Ala Ser Leu Arg
                165                 170                 175
Gln Lys His Ala Gln Gln Gln Lys Val Val Asn Lys Leu Ile Gln Phe
            180                 185                 190
Leu Ile Ser Leu Val Gln Ser Asn Arg Ile Leu Gly Val Lys Arg Lys
        195                 200                 205
Ile Pro Leu Met Leu Asn Asp Ser Gly Ser Ala His Ser Met Pro Lys
    210                 215                 220
Tyr Ser Arg Gln Phe Ser Leu Glu His Val His Gly Ser Gly Pro Tyr
225                 230                 235                 240
Ser Ala Pro Ser Pro Ala Tyr Ser Ser Ser Ser Leu Tyr Ala Pro Asp
                245                 250                 255
Ala Val Ala Ser Ser Gly Pro Ile Ile Ser Asp Ile Thr Glu Leu Ala
            260                 265                 270
Pro Ala Ser Pro Met Ala Ser Pro Gly Gly Ser Ile Asp Glu Arg Pro
        275                 280                 285
Leu Ser Ser Ser Pro Leu Val Arg Val Lys Glu Glu Pro Pro Ser Pro
    290                 295                 300
Pro Gln Ser Pro Arg Val Glu Glu Ala Ser Pro Gly Arg Pro Ser Ser
305                 310                 315                 320
Val Asp Thr Leu Leu Ser Pro Thr Ala Leu Ile Asp Ser Ile Leu Arg
                325                 330                 335
Glu Ser Glu Pro Ala Pro Ala Ser Val Thr Ala Leu Thr Asp Ala Arg
            340                 345                 350
Gly His Thr Asp Thr Glu Gly Arg Pro Pro Ser Pro Pro Pro Thr Ser
        355                 360                 365
Thr Pro Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu Leu
    370                 375                 380
Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln Thr
385                 390                 395                 400
Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp
                405                 410                 415
Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu
            420                 425                 430
Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro
        435                 440                 445
Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln
    450                 455                 460
Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser
465                 470                 475                 480
Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu
                485                 490                 495
Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile
            500                 505                 510
Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val
        515                 520                 525
Ser


<210> 83
<211> 621
<212> PRT
<213> Homo sapiens

<400> 83
Met Ser Gly Cys Gly Leu Phe Leu Arg Thr Thr Ala Ala Ala Arg Ala
 1               5                  10                  15
Cys Arg Gly Leu Val Val Ser Thr Ala Asn Arg Arg Leu Leu Arg Thr
            20                  25                  30
Ser Pro Pro Val Arg Ala Phe Ala Lys Glu Leu Phe Leu Gly Lys Ile
        35                  40                  45
Lys Lys Lys Glu Val Phe Pro Phe Pro Glu Val Ser Gln Asp Glu Leu
    50                  55                  60
Asn Glu Ile Asn Gln Phe Leu Gly Pro Val Glu Lys Phe Phe Thr Glu
65                  70                  75                  80
Glu Val Asp Ser Arg Lys Ile Asp Gln Glu Gly Lys Ile Pro Asp Glu
                85                  90                  95
Thr Leu Glu Lys Leu Lys Ser Leu Gly Leu Phe Gly Leu Gln Val Pro
            100                 105                 110
Glu Glu Tyr Gly Gly Leu Gly Phe Ser Asn Thr Met Tyr Ser Arg Leu
        115                 120                 125
Gly Glu Ile Ile Ser Met Asp Gly Ser Ile Thr Val Thr Leu Ala Ala
    130                 135                 140
His Gln Ala Ile Gly Leu Lys Gly Ile Ile Leu Ala Gly Thr Glu Glu
145                 150                 155                 160
Gln Lys Ala Lys Tyr Leu Pro Lys Leu Ala Ser Gly Glu His Ile Ala
                165                 170                 175
Ala Phe Cys Leu Thr Glu Pro Ala Ser Gly Ser Asp Ala Ala Ser Ile
            180                 185                 190
Arg Ser Arg Ala Thr Leu Ser Glu Asp Lys Lys His Tyr Ile Leu Asn
        195                 200                 205
Gly Ser Lys Val Trp Ile Thr Asn Gly Gly Leu Ala Asn Ile Phe Thr
    210                 215                 220
Val Phe Ala Lys Thr Glu Val Val Asp Ser Asp Gly Ser Val Lys Asp
225                 230                 235                 240
Lys Ile Thr Ala Phe Ile Val Glu Arg Asp Phe Gly Gly Val Thr Asn
                245                 250                 255
Gly Lys Pro Glu Asp Lys Leu Gly Ile Arg Gly Ser Asn Thr Cys Glu
            260                 265                 270
Val His Phe Glu Asn Thr Lys Ile Pro Val Glu Asn Ile Leu Gly Glu
        275                 280                 285
Val Gly Asp Gly Phe Lys Val Ala Met Asn Ile Leu Asn Ser Gly Arg
    290                 295                 300
Phe Ser Met Gly Ser Val Val Ala Gly Leu Leu Lys Arg Leu Ile Glu
305                 310                 315                 320
Met Thr Ala Glu Tyr Ala Cys Thr Arg Lys Gln Phe Asn Lys Arg Leu
                325                 330                 335
Ser Glu Phe Gly Leu Ile Gln Glu Lys Phe Ala Leu Met Ala Gln Lys
            340                 345                 350
Ala Tyr Val Met Glu Ser Met Thr Tyr Leu Thr Ala Gly Met Leu Asp
        355                 360                 365
Gln Pro Gly Phe Pro Asp Cys Ser Ile Glu Ala Ala Met Val Lys Val
    370                 375                 380
Phe Ser Ser Glu Ala Ala Trp Gln Cys Val Ser Glu Ala Leu Gln Ile
385                 390                 395                 400
Leu Gly Gly Leu Gly Tyr Thr Arg Asp Tyr Pro Tyr Glu Arg Ile Leu
                405                 410                 415
Arg Asp Thr Arg Ile Leu Leu Ile Phe Glu Gly Thr Asn Glu Ile Leu
            420                 425                 430
Arg Met Tyr Ile Ala Leu Thr Gly Leu Gln His Ala Gly Arg Ile Leu
        435                 440                 445
Thr Thr Arg Ile His Glu Leu Lys Gln Ala Lys Val Ser Thr Val Met
    450                 455                 460
Asp Thr Val Gly Arg Arg Leu Arg Asp Ser Leu Gly Arg Thr Val Asp
465                 470                 475                 480
Leu Gly Leu Thr Gly Asn His Gly Val Val His Pro Ser Leu Ala Asp
                485                 490                 495
Ser Ala Asn Lys Phe Glu Glu Asn Thr Tyr Cys Phe Gly Arg Thr Val
            500                 505                 510
Glu Thr Leu Leu Leu Arg Phe Gly Lys Thr Ile Met Glu Glu Gln Leu
        515                 520                 525
Val Leu Lys Arg Val Ala Asn Ile Leu Ile Asn Leu Tyr Gly Met Thr
    530                 535                 540
Ala Val Leu Ser Arg Ala Ser Arg Ser Ile Arg Ile Gly Leu Arg Asn
545                 550                 555                 560
His Asp His Glu Val Leu Leu Ala Asn Thr Phe Cys Val Glu Ala Tyr
                565                 570                 575
Leu Gln Asn Leu Phe Ser Leu Ser Gln Leu Asp Lys Tyr Ala Pro Glu
            580                 585                 590
Asn Leu Asp Glu Gln Ile Lys Lys Val Ser Gln Gln Ile Leu Glu Lys
        595                 600                 605
Arg Ala Tyr Ile Cys Ala His Pro Leu Asp Arg Thr Cys
    610                 615                 620

<210> 84
<211> 345
<212> PRT
<213> Homo sapiens

<400> 84
Met Leu Arg Pro Ala Gly Leu Trp Arg Leu Cys Arg Arg Pro Trp Ala
 1               5                  10                  15
Ala Arg Val Pro Ala Glu Asn Leu Gly Arg Arg Glu Val Thr Ser Gly
            20                  25                  30
Val Ser Pro Arg Gly Ser Thr Ser Pro Arg Thr Leu Asn Ile Phe Asp
        35                  40                  45
Arg Asp Leu Lys Arg Lys Gln Lys Asn Trp Ala Ala Arg Gln Pro Glu
    50                  55                  60
Pro Thr Lys Phe Asp Tyr Leu Lys Glu Glu Val Gly Ser Arg Ile Ala
65                  70                  75                  80
Asp Arg Val Tyr Asp Ile Pro Arg Asn Phe Pro Leu Ala Leu Asp Leu
                85                  90                  95
Gly Cys Gly Arg Gly Tyr Ile Ala Gln Tyr Leu Asn Lys Glu Thr Ile
            100                 105                 110
Gly Lys Phe Phe Gln Ala Asp Ile Ala Glu Asn Ala Leu Lys Asn Ser
        115                 120                 125
Ser Glu Thr Glu Ile Pro Thr Val Ser Val Leu Ala Asp Glu Glu Phe
    130                 135                 140
Leu Pro Phe Lys Glu Asn Thr Phe Asp Leu Val Val Ser Ser Leu Ser
145                 150                 155                 160
Leu His Trp Val Asn Asp Leu Pro Arg Ala Leu Glu Gln Ile His Tyr
                165                 170                 175
Ile Leu Lys Pro Asp Gly Val Phe Ile Gly Ala Met Phe Gly Gly Asp
            180                 185                 190
Thr Leu Tyr Glu Leu Arg Cys Ser Leu Gln Leu Ala Glu Thr Glu Arg
        195                 200                 205
Glu Gly Gly Phe Ser Pro His Ile Ser Pro Phe Thr Ala Val Asn Asp
    210                 215                 220
Leu Gly His Leu Leu Gly Arg Ala Gly Phe Asn Thr Leu Thr Val Asp
225                 230                 235                 240
Thr Asp Glu Ile Gln Val Asn Tyr Pro Gly Met Phe Glu Leu Met Glu
                245                 250                 255
Asp Leu Gln Gly Met Gly Glu Ser Asn Cys Ala Trp Asn Arg Lys Ala
            260                 265                 270
Leu Leu His Arg Asp Thr Met Leu Ala Ala Ala Ala Val Tyr Arg Glu
        275                 280                 285
Met Tyr Arg Asn Glu Asp Gly Ser Val Pro Ala Thr Tyr Gln Ile Tyr
    290                 295                 300
Tyr Met Ile Gly Trp Lys Tyr His Glu Ser Gln Ala Arg Pro Ala Glu
305                 310                 315                 320
Arg Gly Ser Ala Thr Val Ser Phe Gly Glu Leu Gly Lys Ile Asn Asn
                325                 330                 335
Leu Met Pro Pro Gly Lys Lys Ser Gln
            340                 345

<210> 85
<211> 285
<212> PRT
<213> Homo sapiens

<400> 85
Met Glu Val Pro Pro Pro Ala Pro Arg Ser Phe Leu Cys Arg Ala Leu
 1               5                  10                  15
Cys Leu Phe Pro Arg Val Phe Ala Ala Glu Ala Val Thr Ala Asp Ser
            20                  25                  30
Glu Val Leu Glu Glu Arg Gln Lys Arg Leu Pro Tyr Val Pro Glu Pro
        35                  40                  45
Tyr Tyr Pro Glu Ser Gly Trp Asp Arg Leu Arg Glu Leu Phe Gly Lys
    50                  55                  60
Asp Glu Gln Gln Arg Ile Ser Lys Asp Leu Ala Asn Ile Cys Lys Thr
65                  70                  75                  80
Ala Ala Thr Ala Gly Ile Ile Gly Trp Val Tyr Gly Gly Ile Pro Ala
                85                  90                  95
Phe Ile His Ala Lys Gln Gln Tyr Ile Glu Gln Ser Gln Ala Glu Ile
            100                 105                 110
Tyr His Asn Arg Phe Asp Ala Val Gln Ser Ala His Arg Ala Ala Thr
        115                 120                 125
Arg Gly Phe Ile Arg Tyr Gly Trp Arg Trp Gly Trp Arg Thr Ala Val
    130                 135                 140
Phe Val Thr Ile Phe Asn Thr Val Asn Thr Ser Leu Asn Val Tyr Arg
145                 150                 155                 160
Asn Lys Asp Ala Leu Ser His Phe Val Ile Ala Gly Ala Val Thr Gly
                165                 170                 175
Ser Leu Phe Arg Ile Asn Val Gly Leu Arg Gly Leu Val Ala Gly Gly
            180                 185                 190
Ile Ile Gly Ala Leu Leu Gly Thr Pro Val Gly Gly Leu Leu Met Ala
        195                 200                 205
Phe Gln Lys Tyr Ser Gly Glu Thr Val Gln Glu Arg Lys Gln Lys Asp
    210                 215                 220
Arg Lys Ala Leu His Glu Leu Lys Leu Glu Glu Trp Lys Gly Arg Leu
225                 230                 235                 240
Gln Val Thr Glu His Leu Pro Glu Lys Ile Glu Ser Ser Leu Gln Glu
                245                 250                 255
Asp Glu Pro Glu Asn Asp Ala Lys Lys Ile Glu Ala Leu Leu Asn Leu
            260                 265                 270
Pro Arg Asn Pro Ser Val Ile Asp Lys Gln Asp Lys Asp
        275                 280                 285

<210> 86
<211> 261
<212> PRT
<213> Homo sapiens

<400> 86
Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr
 1               5                  10                  15
Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly
            20                  25                  30
Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu
        35                  40                  45
Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp
    50                  55                  60
Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly
65                  70                  75                  80
Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val
                85                  90                  95
Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu
            100                 105                 110
Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val
        115                 120                 125
Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly
    130                 135                 140
Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu
145                 150                 155                 160
Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val
                165                 170                 175
Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg
            180                 185                 190
Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser
        195                 200                 205
Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro
    210                 215                 220
Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile
225                 230                 235                 240
Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala
                245                 250                 255
Ile Arg Met Gln Pro
            260

<210> 87
<211> 801
<212> PRT
<213> Homo sapiens

<400> 87
Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn
 1               5                  10                  15
Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg
            20                  25                  30
Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met
        35                  40                  45
Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro
    50                  55                  60
Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln
65                  70                  75                  80
Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala
                85                  90                  95
Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp
            100                 105                 110
Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg
        115                 120                 125
Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp
    130                 135                 140
Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp
145                 150                 155                 160
Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys
                165                 170                 175
Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro
            180                 185                 190
Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser
        195                 200                 205
Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr
    210                 215                 220
Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile
225                 230                 235                 240
Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser
                245                 250                 255
Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro
            260                 265                 270
Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro
        275                 280                 285
Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly
    290                 295                 300
Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser
305                 310                 315                 320
Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln
                325                 330                 335
Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His
            340                 345                 350
Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr
        355                 360                 365
Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His
    370                 375                 380
Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys
385                 390                 395                 400
Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala
                405                 410                 415
Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp
            420                 425                 430
His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe
        435                 440                 445
Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro
    450                 455                 460
Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser
465                 470                 475                 480
Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu
                485                 490                 495
Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser
            500                 505                 510
Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg
        515                 520                 525
Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys
    530                 535                 540
Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala
545                 550                 555                 560
Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro
                565                 570                 575
Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly
            580                 585                 590
Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser
        595                 600                 605
Gly Gly Ser Gly Thr Lys Leu Pro Lys Lys Ala Thr Lys Thr Ala Pro
    610                 615                 620
Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu Glu Ser Arg
625                 630                 635                 640
Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys
                645                 650                 655
Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ala Arg
            660                 665                 670
Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu Ile Asp Phe
        675                 680                 685
Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Leu
    690                 695                 700
Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile Lys Lys Pro
705                 710                 715                 720
Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys Arg Glu Leu
                725                 730                 735
Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser Thr Lys Lys
            740                 745                 750
Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser Ala Gln Gln
        755                 760                 765
Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser Asp Ser Ser
    770                 775                 780
Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp Ser Asp Ser
785                 790                 795                 800
Gly


<210> 88
<211> 128
<212> PRT
<213> Homo sapiens

<400> 88
Met Ala Gly Ser Gly Val Arg Gln Ala Thr Ser Thr Ala Ser Thr Phe
 1               5                  10                  15
Val Lys Pro Ile Phe Ser Arg Asp Met Asn Glu Ala Lys Arg Arg Val
            20                  25                  30
Arg Glu Leu Tyr Arg Ala Trp Tyr Arg Glu Val Pro Asn Thr Val His
        35                  40                  45
Gln Phe Gln Leu Asp Ile Thr Val Lys Met Gly Arg Asp Lys Val Arg
    50                  55                  60
Glu Met Phe Met Lys Asn Ala His Val Thr Asp Pro Arg Val Val Asp
65                  70                  75                  80
Leu Leu Val Ile Lys Gly Lys Ile Glu Leu Glu Glu Thr Ile Lys Val
                85                  90                  95
Trp Lys Gln Arg Thr His Val Met Arg Phe Phe His Glu Thr Glu Ala
            100                 105                 110
Pro Arg Pro Lys Asp Phe Leu Ser Lys Phe Tyr Val Gly His Asp Pro
        115                 120                 125

<210> 89
<211> 575
<212> PRT
<213> Homo sapiens

<400> 89
Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu
 1               5                  10                  15
Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Thr
            20                  25                  30
Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Thr Asp
        35                  40                  45
Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro
    50                  55                  60
Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn
65                  70                  75                  80
Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn
                85                  90                  95
Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe
            100                 105                 110
Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg
        115                 120                 125
Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn
    130                 135                 140
Asn Ser Thr Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr
145                 150                 155                 160
Val Thr Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val
                165                 170                 175
Asn Asn Val Val Val Asp Gly Arg Thr Leu Lys Ala Ser Leu Gly Thr
            180                 185                 190
Thr Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro
        195                 200                 205
Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Thr
    210                 215                 220
Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu
225                 230                 235                 240
Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Thr
                245                 250                 255
Gly Ser Val Asp Lys Asn Lys Asn Lys Val Thr Pro Leu Gln Arg Tyr
            260                 265                 270
Asp Thr Pro Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly
        275                 280                 285
Asp Asn Ser Gln Gln Ile Ser Asn Ser Asp Thr Pro Ser Pro Pro Pro
    290                 295                 300
Gly Leu Ser Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His
305                 310                 315                 320
Ser Ala Arg Ser Pro Phe Glu Gly Ala Val Thr Glu Ser Gln Ser Leu
                325                 330                 335
Phe Ser Asp Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro
            340                 345                 350
Pro Phe Pro Ser Ser Pro Gln Thr Ser Ser Asp Trp Pro Thr Ala Pro
        355                 360                 365
Glu Pro Gln Ser Leu Phe Thr Ser Glu Thr Ile Pro Val Ser Ser Ser
    370                 375                 380
Thr Asp Trp Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu
385                 390                 395                 400
Asp Asp Leu Gly Phe Asp Pro Phe Asp Val Thr Arg Lys Ala Leu Ala
                405                 410                 415
Asp Leu Ile Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser
            420                 425                 430
Pro Thr Ser Leu Gln Asn Ser Ser Ser His Thr Thr Thr Ala Lys Gly
        435                 440                 445
Pro Gly Ser Gly Phe Leu His Pro Ala Ala Ala Thr Asn Ala Asn Ser
    450                 455                 460
Leu Asn Ser Thr Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln
465                 470                 475                 480
Gln His Arg Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala
                485                 490                 495
Arg Tyr Pro Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn
            500                 505                 510
His Thr Ala Asn Pro Thr Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu
        515                 520                 525
Pro Pro Gln His Asn Thr Gly Leu Gly Gly Ile Pro Val Ala Gly Glu
    530                 535                 540
Glu Glu Val Lys Val Ser Thr Met Pro Leu Ser Thr Ser Ser His Ser
545                 550                 555                 560
Leu Gln Gln Gly Gln Gln Pro Thr Ser Leu His Thr Thr Val Ala
                565                 570                 575

<210> 90
<211> 270
<212> PRT
<213> Homo sapiens

<400> 90
Met Leu Gln Ala Cys Lys Met Glu Gly Phe Pro Leu Val Pro Pro Pro
 1               5                  10                  15
Ser Glu Asp Leu Val Pro Tyr Asp Thr Asp Leu Tyr Gln Arg Gln Thr
            20                  25                  30
His Glu Tyr Tyr Pro Tyr Leu Ser Ser Asp Gly Glu Ser His Ser Asp
        35                  40                  45
His Tyr Trp Asp Phe His Pro His His Val His Ser Glu Phe Glu Ser
    50                  55                  60
Phe Ala Glu Asn Asn Phe Thr Glu Leu Gln Ser Val Gln Pro Pro Gln
65                  70                  75                  80
Leu Gln Gln Leu Tyr Arg His Met Glu Leu Glu Gln Met His Val Leu
                85                  90                  95
Asp Thr Pro Met Val Pro Pro His Pro Ser Leu Gly His Gln Val Ser
            100                 105                 110
Tyr Leu Pro Arg Met Cys Leu Gln Tyr Pro Ser Leu Ser Pro Ala Gln
        115                 120                 125
Pro Ser Ser Asp Glu Glu Glu Gly Glu Arg Gln Ser Pro Pro Leu Glu
    130                 135                 140
Val Ser Asp Gly Glu Ala Asp Gly Leu Glu Pro Gly Pro Gly Leu Leu
145                 150                 155                 160
Pro Gly Glu Thr Gly Ser Lys Lys Lys Ile Arg Leu Tyr Gln Phe Leu
                165                 170                 175
Leu Asp Leu Leu Arg Ser Gly Asp Met Lys Asp Ser Ile Trp Trp Val
            180                 185                 190
Asp Lys Asp Lys Gly Thr Phe Gln Phe Ser Ser Lys His Lys Glu Ala
        195                 200                 205
Leu Ala His Arg Trp Gly Ile Gln Lys Gly Asn Arg Lys Lys Met Thr
    210                 215                 220
Tyr Gln Lys Met Ala Arg Ala Leu Arg Asn Tyr Gly Lys Thr Gly Glu
225                 230                 235                 240
Val Lys Lys Val Lys Lys Lys Leu Thr Tyr Gln Phe Ser Gly Glu Val
                245                 250                 255
Leu Gly Arg Gly Gly Leu Ala Glu Arg Arg His Pro Pro His
            260                 265                 270

<210> 91
<211> 338
<212> PRT
<213> Homo sapiens

<400> 91
Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335
Leu Lys


<210> 92
<211> 645
<212> PRT
<213> Homo sapiens

<400> 92
Met Tyr Phe Pro Ser Trp Leu Ser Gln Leu Tyr Arg Gly Leu Ser Arg
 1               5                  10                  15
Pro Ile Arg Arg Thr Thr Gln Pro Ile Trp Gly Ser Leu Tyr Arg Ser
            20                  25                  30
Leu Leu Gln Ser Ser Gln Arg Arg Ile Pro Glu Phe Ser Ser Phe Val
        35                  40                  45
Val Arg Thr Asn Thr Cys Gly Glu Leu Arg Ser Ser His Leu Gly Gln
    50                  55                  60
Glu Val Thr Leu Cys Gly Trp Ile Gln Tyr Arg Arg Gln Asn Thr Phe
65                  70                  75                  80
Leu Val Leu Arg Asp Phe Asp Gly Leu Val Gln Val Ile Ile Pro Gln
                85                  90                  95
Asp Glu Ser Ala Ala Ser Val Lys Lys Ile Leu Cys Glu Ala Pro Val
            100                 105                 110
Glu Ser Val Val Gln Val Ser Gly Thr Val Ile Ser Arg Pro Ala Gly
        115                 120                 125
Gln Glu Asn Pro Lys Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys
    130                 135                 140
Thr Ala Glu Leu Leu Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys
145                 150                 155                 160
Asn Phe Val Lys Lys Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu
                165                 170                 175
Asp Leu Arg Ser Phe Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln
            180                 185                 190
Met Val Met Lys Met Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val
        195                 200                 205
Asp Ile Glu Thr Pro Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys
    210                 215                 220
Glu Phe Leu Val Pro Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro
225                 230                 235                 240
Gln Ser Pro Gln Gln Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp
                245                 250                 255
Arg Tyr Phe Gln Val Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro
            260                 265                 270
Asp Arg Gln Pro Glu Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val
        275                 280                 285
Asp Gln Thr Gly Ile Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser
    290                 295                 300
Trp Pro Asn Asp Lys Asp Pro Val Val Val Pro Phe Pro Thr Met Thr
305                 310                 315                 320
Phe Ala Glu Val Leu Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg
                325                 330                 335
Phe Gly Met Lys Ile Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu
            340                 345                 350
Ile Gly Phe Leu Gln Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys
        355                 360                 365
Ala Ile Cys Ile Pro Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile
    370                 375                 380
Glu Ser Ile Arg Asn Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu
385                 390                 395                 400
Pro Val Phe Leu Asn Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn
                405                 410                 415
Phe Ile Met Glu Ser Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr
            420                 425                 430
Gln Glu Glu Asp Val Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala
        435                 440                 445
Cys Ser Leu Leu Gly Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Glu
    450                 455                 460
Thr Arg Gly Val Val Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp
465                 470                 475                 480
Val Val Asp Phe Pro Leu Phe Leu Pro Lys Glu Glu Asn Pro Arg Glu
                485                 490                 495
Leu Glu Ser Ala His His Pro Phe Thr Ala Pro His Pro Ser Asp Ile
            500                 505                 510
His Leu Leu Tyr Thr Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp
        515                 520                 525
Leu Val Leu Asn Gly Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His
    530                 535                 540
Asn Ala Glu Leu Gln Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp
545                 550                 555                 560
Val Lys Met Leu Ser His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro
                565                 570                 575
Pro His Gly Gly Ile Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val
            580                 585                 590
Thr Gly Ser Pro Ser Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe
        595                 600                 605
Arg Gly His Asp Leu Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu
    610                 615                 620
Glu Leu Lys Pro Tyr His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys
625                 630                 635                 640
Ala Glu Arg Ala His
                645

<210> 93
<211> 116
<212> PRT
<213> Homo sapiens

<400> 93
Met Gly Ser Arg Leu Ser Gln Pro Phe Glu Ser Tyr Ile Thr Ala Pro
 1               5                  10                  15
Pro Gly Thr Ala Ala Ala Pro Ala Lys Pro Ala Pro Pro Ala Thr Pro
            20                  25                  30
Gly Ala Pro Thr Ser Pro Ala Glu His Arg Leu Leu Lys Thr Cys Trp
        35                  40                  45
Ser Cys Arg Val Leu Ser Gly Leu Gly Leu Met Gly Ala Gly Gly Tyr
    50                  55                  60
Val Tyr Trp Val Ala Arg Lys Pro Met Lys Met Gly Tyr Pro Pro Ser
65                  70                  75                  80
Pro Trp Thr Ile Thr Gln Met Val Ile Gly Leu Ser Glu Asn Gln Gly
                85                  90                  95
Ile Ala Thr Trp Gly Ile Val Val Met Ala Asp Pro Lys Gly Lys Ala
            100                 105                 110
Tyr Arg Val Val
        115

<210> 94
<211> 543
<212> PRT
<213> Homo sapiens

<400> 94
Met Glu Gln Val Asn Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser
 1               5                  10                  15
Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu Ala Ile Lys
            20                  25                  30
Leu Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr
        35                  40                  45
Ala Lys Lys Gly Asp Tyr Gln Lys Ala Tyr Glu Asp Gly Cys Lys Thr
    50                  55                  60
Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala
65                  70                  75                  80
Ala Leu Glu Phe Leu Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu
                85                  90                  95
Glu Gly Leu Lys His Glu Ala Asn Asn Pro Gln Leu Lys Glu Gly Leu
            100                 105                 110
Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe
        115                 120                 125
Asn Met Pro Asn Leu Tyr Gln Lys Leu Glu Ser Asp Pro Arg Thr Arg
    130                 135                 140
Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu Arg
145                 150                 155                 160
Asn Lys Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile Met
                165                 170                 175
Thr Thr Leu Ser Val Leu Leu Gly Val Asp Leu Gly Ser Met Asp Glu
            180                 185                 190
Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys Glu
        195                 200                 205
Thr Lys Pro Glu Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln
    210                 215                 220
Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys Lys Lys Asp
225                 230                 235                 240
Phe Asp Thr Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro
                245                 250                 255
Thr Asn Met Thr Tyr Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys
            260                 265                 270
Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu Val
        275                 280                 285
Gly Arg Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala
    290                 295                 300
Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys Asp Ala Ile
305                 310                 315                 320
His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu
                325                 330                 335
Lys Lys Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu
            340                 345                 350
Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn
        355                 360                 365
Glu Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr
    370                 375                 380
Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr Ser Asn Arg
385                 390                 395                 400
Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys Asp
                405                 410                 415
Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr
            420                 425                 430
Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala Met
        435                 440                 445
Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala
    450                 455                 460
Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn Arg His Asp
465                 470                 475                 480
Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val Gln
                485                 490                 495
Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln
            500                 505                 510
Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile Ala
        515                 520                 525
Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile Arg
    530                 535                 540

<210> 95
<211> 364
<212> PRT
<213> Homo sapiens

<400> 95
Met Thr Ser Glu Leu Asp Ile Phe Val Gly Asn Thr Thr Leu Ile Asp
 1               5                  10                  15
Glu Asp Val Tyr Arg Leu Trp Leu Asp Gly Tyr Ser Val Thr Asp Ala
            20                  25                  30
Val Ala Leu Arg Val Arg Ser Gly Ile Leu Glu Gln Thr Gly Ala Thr
        35                  40                  45
Ala Ala Val Leu Gln Ser Asp Thr Met Asp His Tyr Arg Thr Phe His
    50                  55                  60
Met Leu Glu Arg Leu Leu His Ala Pro Pro Lys Leu Leu His Gln Leu
65                  70                  75                  80
Ile Phe Gln Ile Pro Pro Ser Arg Gln Ala Leu Leu Ile Glu Arg Tyr
                85                  90                  95
Tyr Ala Phe Asp Glu Ala Phe Val Arg Glu Val Leu Gly Lys Lys Leu
            100                 105                 110
Ser Lys Gly Thr Lys Lys Asp Leu Asp Asp Ile Ser Thr Lys Thr Gly
        115                 120                 125
Ile Thr Leu Lys Ser Cys Arg Arg Gln Phe Asp Asn Phe Lys Arg Val
    130                 135                 140
Phe Lys Val Val Glu Glu Met Arg Gly Ser Leu Val Asp Asn Ile Gln
145                 150                 155                 160
Gln His Phe Leu Leu Ser Asp Arg Leu Ala Arg Asp Tyr Ala Ala Ile
                165                 170                 175
Val Phe Phe Ala Asn Asn Arg Phe Glu Thr Gly Lys Lys Lys Leu Gln
            180                 185                 190
Tyr Leu Ser Phe Gly Asp Phe Ala Phe Cys Ala Glu Leu Met Ile Gln
        195                 200                 205
Asn Trp Thr Leu Gly Ala Val Gly Glu Ala Pro Thr Asp Pro Asp Ser
    210                 215                 220
Gln Met Asp Asp Met Asp Met Asp Leu Asp Lys Glu Phe Leu Gln Asp
225                 230                 235                 240
Leu Lys Glu Leu Lys Val Leu Val Ala Asp Lys Asp Leu Leu Asp Leu
                245                 250                 255
His Lys Ser Leu Val Cys Thr Ala Leu Arg Gly Lys Leu Gly Val Phe
            260                 265                 270
Ser Glu Met Glu Ala Asn Phe Lys Asn Leu Ser Arg Gly Leu Val Asn
        275                 280                 285
Val Ala Ala Lys Leu Thr His Asn Lys Asp Val Arg Asp Leu Phe Val
    290                 295                 300
Asp Leu Val Glu Lys Phe Val Glu Pro Cys Arg Ser Asp His Trp Pro
305                 310                 315                 320
Leu Ser Asp Val Arg Phe Phe Leu Asn Gln Tyr Ser Ala Ser Val His
                325                 330                 335
Ser Leu Asp Gly Phe Arg His Gln Ala Leu Trp Asp Arg Tyr Met Gly
            340                 345                 350
Thr Leu Arg Gly Cys Leu Leu Arg Leu Tyr His Asp
        355                 360

<210> 96
<211> 621
<212> PRT
<213> Homo sapiens

<400> 96
Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr
 1               5                  10                  15
Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe
            20                  25                  30
Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg
        35                  40                  45
Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu
    50                  55                  60
Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp
65                  70                  75                  80
Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr
                85                  90                  95
Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu
            100                 105                 110
Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys
        115                 120                 125
Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu
    130                 135                 140
Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe
145                 150                 155                 160
Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala
                165                 170                 175
Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile
            180                 185                 190
Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His
        195                 200                 205
Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val
    210                 215                 220
Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn
225                 230                 235                 240
Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp
                245                 250                 255
Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val
            260                 265                 270
Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val
        275                 280                 285
Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile
    290                 295                 300
Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly
305                 310                 315                 320
Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val
                325                 330                 335
Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu
            340                 345                 350
Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg
        355                 360                 365
Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser
    370                 375                 380
Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly
385                 390                 395                 400
Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys
                405                 410                 415
Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser
            420                 425                 430
Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser
        435                 440                 445
Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser
    450                 455                 460
Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu
465                 470                 475                 480
Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser
                485                 490                 495
His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp
            500                 505                 510
Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser
        515                 520                 525
Val Asn Glu Asn Gly Leu Val Thr Val Ala Asp Tyr Ile Ser Arg Ala
    530                 535                 540
Glu Ser Gln Ser Arg Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys
545                 550                 555                 560
Asn Lys Lys Glu Met Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser
                565                 570                 575
Glu Lys Ala Ile Asn Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser
            580                 585                 590
Lys Leu Gln Arg Thr Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu
        595                 600                 605
Glu Asn Thr Gln Glu Ala Ala Val Leu Asn Gly Val Ser
    610                 615                 620

<210> 97
<211> 254
<212> PRT
<213> Homo sapiens

<400> 97
Met Ala Ala Thr Ala Arg Arg Gly Trp Gly Ala Ala Ala Val Ala Ala
 1               5                  10                  15
Gly Leu Arg Arg Arg Phe Cys His Met Leu Lys Asn Pro Tyr Thr Ile
            20                  25                  30
Lys Lys Gln Pro Leu His Gln Phe Val Gln Arg Pro Leu Phe Pro Leu
        35                  40                  45
Pro Ala Ala Phe Tyr His Pro Val Arg Tyr Met Phe Ile Gln Thr Gln
    50                  55                  60
Asp Thr Pro Asn Pro Asn Ser Leu Lys Phe Ile Pro Gly Lys Pro Val
65                  70                  75                  80
Leu Glu Thr Arg Thr Met Asp Phe Pro Thr Pro Ala Ala Ala Phe Arg
                85                  90                  95
Ser Pro Leu Ala Arg Gln Leu Phe Arg Ile Glu Gly Val Lys Ser Val
            100                 105                 110
Phe Phe Gly Pro Asp Phe Ile Thr Val Thr Lys Glu Asn Glu Glu Leu
        115                 120                 125
Asp Trp Asn Leu Leu Lys Pro Asp Ile Tyr Ala Thr Ile Met Asp Phe
    130                 135                 140
Phe Ala Ser Gly Leu Pro Leu Val Thr Glu Glu Thr Pro Ser Gly Glu
145                 150                 155                 160
Ala Gly Ser Glu Glu Asp Asp Glu Val Val Ala Met Ile Lys Glu Leu
                165                 170                 175
Leu Asp Thr Arg Ile Arg Pro Thr Val Gln Glu Asp Gly Gly Asp Val
            180                 185                 190
Ile Tyr Lys Gly Phe Glu Asp Gly Ile Val Gln Leu Lys Leu Gln Gly
        195                 200                 205
Ser Cys Thr Ser Cys Pro Ser Ser Ile Ile Thr Leu Lys Asn Gly Ile
    210                 215                 220
Gln Asn Met Leu Gln Phe Tyr Ile Pro Glu Val Glu Gly Val Glu Gln
225                 230                 235                 240
Val Met Asp Asp Glu Ser Asp Glu Lys Glu Ala Asn Ser Pro
                245                 250

<210> 98
<211> 697
<212> PRT
<213> Homo sapiens

<400> 98
Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro
 1               5                  10                  15
Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met
            20                  25                  30
Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn
        35                  40                  45
Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys
    50                  55                  60
Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu
65                  70                  75                  80
Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val
                85                  90                  95
Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu
            100                 105                 110
Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys
        115                 120                 125
Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser
    130                 135                 140
Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys
145                 150                 155                 160
Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly
                165                 170                 175
Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp
            180                 185                 190
Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr
        195                 200                 205
Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu
    210                 215                 220
Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys
225                 230                 235                 240
Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu
                245                 250                 255
Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu
            260                 265                 270
Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg His Ala
        275                 280                 285
Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile
    290                 295                 300
His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu
305                 310                 315                 320
Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala Leu Arg
                325                 330                 335
Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser Arg Leu
            340                 345                 350
Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg Glu Leu
        355                 360                 365
Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys Asn Lys
    370                 375                 380
Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu Lys Glu
385                 390                 395                 400
Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser Cys Lys
                405                 410                 415
Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val Ile Val
            420                 425                 430
Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn Leu Leu
        435                 440                 445
Gly Ser Pro Lys Ile Lys Lys Gly Leu Ser Pro His Cys Asn Gly Ser
    450                 455                 460
Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr Gly Ser Arg
465                 470                 475                 480
Glu Gly Ser Asp Val Ala Cys Thr Glu Gly Ile Cys Asn His Asp Glu
                485                 490                 495
His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys Glu Asp Asp
            500                 505                 510
Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu Asn Asp Thr
        515                 520                 525
Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile Leu Lys Cys
    530                 535                 540
Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp Pro Gly Asn
545                 550                 555                 560
Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His Arg Asp Lys
                565                 570                 575
Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu Lys Gly Gly
            580                 585                 590
Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro Gln Phe Ala
        595                 600                 605
Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys Gly Ala Lys
    610                 615                 620
Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser Asp Glu Glu
625                 630                 635                 640
Ile Phe Ile Ser Gln Asp Glu Ile Gln Ser Phe Met Ala Asn Asn Gln
                645                 650                 655
Ser Phe Tyr Ser Asn Arg Glu Gln Tyr Arg Gln His Leu Lys Glu Lys
            660                 665                 670
Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro Ile Cys Ser
        675                 680                 685
Gly Trp Leu Thr Thr Ala Gly Ala Asn
    690                 695

<210> 99
<211> 851
<212> PRT
<213> Homo sapiens

<400> 99
Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp
 1               5                  10                  15
Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg
            20                  25                  30
Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala
        35                  40                  45
Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu
    50                  55                  60
Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser
65                  70                  75                  80
Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro
                85                  90                  95
Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu
            100                 105                 110
Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu
        115                 120                 125
Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu
    130                 135                 140
Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val
145                 150                 155                 160
Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg
                165                 170                 175
Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln
            180                 185                 190
Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys
        195                 200                 205
Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu
    210                 215                 220
Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala
225                 230                 235                 240
Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu
                245                 250                 255
Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu
            260                 265                 270
Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr
        275                 280                 285
Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val
    290                 295                 300
Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr
305                 310                 315                 320
Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr
                325                 330                 335
Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu
            340                 345                 350
Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro
        355                 360                 365
Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys
    370                 375                 380
Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe
385                 390                 395                 400
Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly
                405                 410                 415
Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser
            420                 425                 430
Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr
        435                 440                 445
Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile
    450                 455                 460
Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln
465                 470                 475                 480
Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu
                485                 490                 495
Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu
            500                 505                 510
Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn
        515                 520                 525
Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg
    530                 535                 540
Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile
545                 550                 555                 560
Leu Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg
                565                 570                 575
Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys
            580                 585                 590
Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly
        595                 600                 605
Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu
    610                 615                 620
Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro
625                 630                 635                 640
Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile
                645                 650                 655
Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu
            660                 665                 670
Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg
        675                 680                 685
Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp
    690                 695                 700
Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser
705                 710                 715                 720
Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp
                725                 730                 735
Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu
            740                 745                 750
Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys
        755                 760                 765
Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln
    770                 775                 780
Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr
785                 790                 795                 800
Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met
                805                 810                 815
Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val
            820                 825                 830
Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro
        835                 840                 845
Ser Asp Phe
    850

<210> 100
<211> 331
<212> PRT
<213> Homo sapiens

<400> 100
Met Gly Ser Ala Gly Leu Ser Arg Leu His Gly Leu Phe Ala Val Tyr
 1               5                  10                  15
Lys Pro Pro Gly Leu Lys Trp Lys His Leu Arg Asp Thr Val Glu Leu
            20                  25                  30
Gln Leu Leu Lys Gly Leu Asn Ala Arg Lys Pro Pro Ala Pro Lys Gln
        35                  40                  45
Arg Val Arg Phe Leu Leu Gly Pro Met Glu Gly Ser Glu Glu Lys Glu
    50                  55                  60
Leu Thr Leu Thr Ala Thr Ser Val Pro Ser Phe Ile Asn His Pro Leu
65                  70                  75                  80
Val Cys Gly Pro Ala Phe Ala His Leu Lys Val Gly Val Gly His Arg
                85                  90                  95
Leu Asp Ala Gln Ala Ser Gly Val Leu Val Leu Gly Val Gly His Gly
            100                 105                 110
Cys Arg Leu Leu Thr Asp Met Tyr Asn Ala His Leu Thr Lys Asp Tyr
        115                 120                 125
Thr Val Arg Gly Leu Leu Gly Lys Ala Thr Asp Asp Phe Arg Glu Asp
    130                 135                 140
Gly Arg Leu Val Glu Lys Thr Thr Tyr Asp His Val Thr Arg Glu Lys
145                 150                 155                 160
Leu Asp Arg Ile Leu Ala Val Ile Gln Gly Ser His Gln Lys Ala Leu
                165                 170                 175
Val Met Tyr Ser Asn Leu Asp Leu Lys Thr Gln Glu Ala Tyr Glu Met
            180                 185                 190
Ala Val Arg Gly Leu Ile Arg Pro Met Asn Lys Ser Pro Met Leu Ile
        195                 200                 205
Thr Gly Ile Arg Cys Leu Tyr Phe Ala Pro Pro Glu Phe Leu Leu Glu
    210                 215                 220
Val Gln Cys Met His Glu Thr Gln Lys Glu Leu Arg Lys Leu Val His
225                 230                 235                 240
Glu Ile Gly Leu Glu Leu Lys Thr Thr Ala Val Cys Thr Gln Val Arg
                245                 250                 255
Arg Thr Arg Asp Gly Phe Phe Thr Leu Asp Ser Ala Leu Leu Arg Thr
            260                 265                 270
Gln Trp Asp Leu Thr Asn Ile Gln Asp Ala Ile Arg Ala Ala Thr Pro
        275                 280                 285
Gln Val Ala Ala Glu Leu Glu Lys Ser Leu Ser Pro Gly Leu Asp Thr
    290                 295                 300
Lys Gln Leu Pro Ser Pro Gly Trp Ser Trp Asp Ser Gln Gly Pro Ser
305                 310                 315                 320
Ser Thr Leu Gly Leu Glu Arg Gly Ala Gly Gln
                325                 330

<210> 101
<211> 4857
<212> PRT
<213> Homo sapiens

<400> 101
Met Val Thr Gly Gly Gly Ala Ala Pro Pro Gly Thr Val Thr Glu Pro
 1               5                  10                  15
Leu Pro Ser Val Ile Val Leu Ser Ala Gly Arg Lys Met Ala Ala Ala
            20                  25                  30
Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala Ala Gly Ala Gly
        35                  40                  45
Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp Gly Cys Met His
    50                  55                  60
Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His Pro Ala Leu Asn
65                  70                  75                  80
Ala Ile Leu Ala Val Thr Ser Arg Gly Thr Ile Lys Val Ile Asp Gly
                85                  90                  95
Thr Ser Gly Ala Thr Leu Gln Ala Ser Ala Leu Ser Ala Lys Pro Gly
            100                 105                 110
Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp Lys Val Ile Phe
        115                 120                 125
Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu Asn Gly Ile Leu
    130                 135                 140
Leu Leu Asp Thr Ala Leu Gln Thr Pro Val Ser Lys Gln Asp Asp Val
145                 150                 155                 160
Val Gln Leu Glu Leu Pro Val Thr Glu Ala Gln Gln Leu Leu Ser Ala
                165                 170                 175
Cys Leu Glu Lys Val Asp Ile Ser Ser Thr Glu Gly Tyr Asp Leu Phe
            180                 185                 190
Ile Thr Gln Leu Lys Asp Gly Leu Lys Asn Thr Ser His Glu Thr Ala
        195                 200                 205
Ala Asn His Lys Val Ala Lys Trp Ala Thr Val Thr Phe His Leu Pro
    210                 215                 220
His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val Asn Glu Leu Lys
225                 230                 235                 240
Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala Ser Ser Val Met
                245                 250                 255
Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro Glu Leu Gly Val
            260                 265                 270
Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr Ser Glu Ala Asn
        275                 280                 285
Arg Arg Glu Thr Phe Thr Ser Trp Pro His Val Gly Tyr Arg Trp Ala
    290                 295                 300
Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His Gln Pro Ala Ser
305                 310                 315                 320
Ser Gly Asp Asp Arg Ala Met Cys Phe Thr Cys Ser Val Cys Leu Val
                325                 330                 335
Cys Trp Glu Pro Thr Asp Glu Pro Trp Ser Glu His Glu Arg His Ser
            340                 345                 350
Pro Asn Cys Pro Phe Val Lys Gly Glu His Thr Gln Asn Val Pro Leu
        355                 360                 365
Ser Val Thr Leu Ala Thr Ser Pro Ala Gln Phe Pro Cys Thr Asp Gly
    370                 375                 380
Thr Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys Pro His Phe Leu
385                 390                 395                 400
Ala Ala Ala Thr Lys Arg Gly Lys Ile Cys Ile Trp Asp Val Ser Lys
                405                 410                 415
Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala Tyr Asp Pro Ala
            420                 425                 430
Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser Ser Gly Val Asp
        435                 440                 445
Ser Arg Arg Pro Thr Leu Ala Trp Leu Glu Asp Ser Ser Ser Cys Ser
    450                 455                 460
Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu Leu Glu Asp Ser
465                 470                 475                 480
Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Thr Gly His Thr Ser
                485                 490                 495
Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Thr Ala Leu Ser Ile
            500                 505                 510
Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val Ala Asn Val Leu
        515                 520                 525
Glu Asp Thr Val Lys Asp Leu Glu Glu Leu Gly Ala Asn Pro Cys Leu
    530                 535                 540
Thr Asn Ser Lys Ser Glu Lys Thr Lys Glu Lys His Gln Glu Gln His
545                 550                 555                 560
Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu Leu Thr Tyr Lys
                565                 570                 575
Ser Pro Ala Thr Ser Pro Ile Ser Ser Asn Ser His Arg Ser Leu Asp
            580                 585                 590
Gly Leu Ser Arg Thr Gln Gly Glu Ser Ile Ser Glu Gln Gly Ser Thr
        595                 600                 605
Asp Asn Glu Ser Cys Thr Asn Ser Glu Leu Asn Ser Pro Leu Val Arg
    610                 615                 620
Arg Thr Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys Glu Ser Asp Glu
625                 630                 635                 640
Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile Met Ser Lys Ser
                645                 650                 655
Leu His Asp Asp Gly Phe Thr Val Pro Gln Ile Ile Glu Met Glu Leu
            660                 665                 670
Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro Val Thr Tyr Ile
        675                 680                 685
Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Thr Ser Pro Asp Ser Glu
    690                 695                 700
Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Thr Leu Val Gln Cys Leu
705                 710                 715                 720
Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys Ile Asp Ser Ile
                725                 730                 735
Thr Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly Leu Arg Thr Cys
            740                 745                 750
Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu Ala Leu Asn Asn
        755                 760                 765
Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg Lys Gly Glu Leu
    770                 775                 780
Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile Ser Val Ile Gln
785                 790                 795                 800
His Glu Ser Pro Ala Asp Val Gln Thr Pro Leu Ile Ile Gln Pro Glu
                805                 810                 815
Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr Lys Met Asn Tyr
            820                 825                 830
Ala Thr Arg Ile Val Thr Leu Glu Glu Glu Pro Ile Lys Ile Gln His
        835                 840                 845
Ile Lys Asp Pro Gln Asp Thr Ile Thr Ser Leu Ile Leu Leu Pro Pro
    850                 855                 860
Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu Pro Ile Glu Asp
865                 870                 875                 880
Met Gln Leu Thr Ser Lys Asn Gly Phe Glu Arg Glu Lys Thr Ser Asp
                885                 890                 895
Ile Ser Thr Leu Gly His Leu Val Ile Thr Thr Gln Gly Gly Tyr Val
            900                 905                 910
Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala Lys Val Glu Pro
        915                 920                 925
Pro Lys Lys Glu Gly Thr Glu Glu Gln Asp Thr Phe Val Ser Val Ile
    930                 935                 940
Tyr Cys Ser Gly Thr Asp Arg Leu Cys Ala Cys Thr Lys Gly Gly Glu
945                 950                 955                 960
Leu His Phe Leu Gln Ile Gly Gly Thr Cys Asp Asp Ile Asp Glu Ala
                965                 970                 975
Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile Glu Pro Ser Ser
            980                 985                 990
Glu Gly Ser Lys Pro Leu Ser Asn Pro Ser Ser Pro Gly Ile Ser Gly
        995                 1000                1005
Val Asp Leu Leu Val Asp Gln Pro Phe Thr Leu Glu Ile Leu Thr Ser
    1010                1015                1020
Leu Val Glu Leu Thr Arg Phe Glu Thr Leu Thr Pro Arg Phe Ser Ala
1025                1030                1035                1040
Thr Val Pro Pro Cys Trp Val Glu Val Gln Gln Glu Gln Gln Gln Arg
                1045                1050                1055
Arg His Pro Gln His Leu His Gln Gln His His Gly Asp Ala Ala Gln
            1060                1065                1070
His Thr Arg Thr Trp Lys Leu Gln Thr Asp Ser Asn Ser Trp Asp Glu
        1075                1080                1085
His Val Phe Glu Leu Val Leu Pro Lys Ala Cys Met Val Gly His Val
    1090                1095                1100
Asp Phe Lys Phe Val Leu Asn Ser Asn Ile Thr Asn Ile Pro Gln Ile
1105                1110                1115                1120
Gln Val Thr Leu Leu Lys Asn Lys Ala Pro Gly Leu Gly Lys Val Asn
                1125                1130                1135
Ala Leu Asn Ile Glu Val Glu Gln Asn Gly Lys Pro Ser Leu Val Asp
            1140                1145                1150
Leu Asn Glu Glu Met Gln His Met Asp Val Glu Glu Ser Gln Cys Leu
        1155                1160                1165
Arg Leu Cys Pro Phe Leu Glu Asp His Lys Glu Asp Ile Leu Cys Gly
    1170                1175                1180
Pro Val Trp Leu Ala Ser Gly Leu Asp Leu Ser Gly His Ala Gly Met
1185                1190                1195                1200
Leu Thr Leu Thr Ser Pro Lys Leu Val Lys Gly Met Ala Gly Gly Lys
                1205                1210                1215
Tyr Arg Ser Phe Leu Ile His Val Lys Ala Val Asn Glu Arg Gly Thr
            1220                1225                1230
Glu Glu Ile Cys Asn Gly Gly Met Arg Pro Val Val Arg Leu Pro Ser
        1235                1240                1245
Leu Lys His Gln Ser Asn Lys Gly Tyr Ser Leu Ala Ser Leu Leu Ala
    1250                1255                1260
Lys Val Ala Ala Gly Lys Glu Lys Ser Ser Asn Val Lys Asn Glu Asn
1265                1270                1275                1280
Thr Ser Gly Thr Arg Lys Ser Glu Asn Leu Arg Gly Cys Asp Leu Leu
                1285                1290                1295
Gln Glu Val Ser Val Thr Ile Arg Arg Phe Lys Lys Thr Ser Ile Ser
            1300                1305                1310
Lys Glu Arg Val Gln Arg Cys Ala Met Leu Gln Phe Ser Glu Phe His
        1315                1320                1325
Glu Lys Leu Val Asn Thr Leu Cys Arg Lys Thr Asp Asp Gly Gln Ile
    1330                1335                1340
Thr Glu His Ala Gln Ser Leu Val Leu Asp Thr Leu Cys Trp Leu Ala
1345                1350                1355                1360
Gly Val His Ser Asn Gly Pro Gly Ser Ser Lys Glu Gly Asn Glu Asn
                1365                1370                1375
Leu Leu Ser Lys Thr Arg Lys Phe Leu Ser Asp Ile Val Arg Val Cys
            1380                1385                1390
Phe Phe Glu Ala Gly Arg Ser Ile Ala His Lys Cys Ala Arg Phe Leu
        1395                1400                1405
Ala Leu Cys Ile Ser Asn Gly Lys Cys Asp Pro Cys Gln Pro Ala Phe
    1410                1415                1420
Gly Pro Val Leu Leu Lys Ala Leu Leu Asp Asn Met Ser Phe Leu Pro
1425                1430                1435                1440
Ala Ala Thr Thr Gly Gly Ser Val Tyr Trp Tyr Phe Val Leu Leu Asn
                1445                1450                1455
Tyr Val Lys Asp Glu Asp Leu Ala Gly Cys Ser Thr Ala Cys Ala Ser
            1460                1465                1470
Leu Leu Thr Ala Val Ser Arg Gln Leu Gln Asp Arg Leu Thr Pro Met
        1475                1480                1485
Glu Ala Leu Leu Gln Thr Arg Tyr Gly Leu Tyr Ser Ser Pro Phe Asp
    1490                1495                1500
Pro Val Leu Phe Asp Leu Glu Met Ser Gly Ser Ser Cys Lys Asn Val
1505                1510                1515                1520
Tyr Asn Ser Ser Ile Gly Val Gln Ser Asp Glu Ile Asp Leu Ser Asp
                1525                1530                1535
Val Leu Ser Gly Asn Gly Lys Val Ser Ser Cys Thr Ala Ala Glu Gly
            1540                1545                1550
Ser Phe Thr Ser Leu Thr Gly Leu Leu Glu Val Glu Pro Leu His Phe
        1555                1560                1565
Thr Cys Val Ser Thr Ser Asp Gly Thr Arg Ile Glu Arg Asp Asp Ala
    1570                1575                1580
Met Ser Ser Phe Gly Val Thr Pro Ala Val Gly Gly Leu Ser Ser Gly
1585                1590                1595                1600
Thr Val Gly Glu Ala Ser Thr Ala Leu Ser Ser Ala Ala Gln Val Ala
                1605                1610                1615
Leu Gln Ser Leu Ser His Ala Met Ala Ser Ala Glu Gln Gln Leu Gln
            1620                1625                1630
Val Leu Gln Glu Lys Gln Gln Gln Leu Leu Lys Leu Gln Gln Gln Lys
        1635                1640                1645
Ala Lys Leu Glu Ala Lys Leu His Gln Thr Thr Ala Ala Ala Ala Ala
    1650                1655                1660
Ala Ala Ser Ala Val Gly Pro Val His Asn Ser Val Pro Ser Asn Pro
1665                1670                1675                1680
Val Ala Ala Pro Gly Phe Phe Ile His Pro Ser Asp Val Ile Pro Pro
                1685                1690                1695
Thr Pro Lys Thr Thr Pro Leu Phe Met Thr Pro Pro Leu Thr Pro Pro
            1700                1705                1710
Asn Glu Ala Val Ser Val Val Ile Asn Ala Glu Leu Ala Gln Leu Phe
        1715                1720                1725
Pro Gly Ser Val Ile Asp Pro Pro Ala Val Asn Leu Ala Ala His Asn
    1730                1735                1740
Lys Asn Ser Asn Lys Ser Arg Met Asn Pro Leu Gly Ser Gly Leu Ala
1745                1750                1755                1760
Leu Ala Ile Ser His Ala Ser His Phe Leu Gln Pro Pro Pro His Gln
                1765                1770                1775
Ser Ile Ile Ile Glu Arg Met His Ser Gly Ala Arg Arg Phe Val Thr
            1780                1785                1790
Leu Asp Phe Gly Arg Pro Ile Leu Leu Thr Asp Val Leu Ile Pro Thr
        1795                1800                1805
Cys Gly Asp Leu Ala Ser Leu Ser Ile Asp Ile Trp Thr Leu Gly Glu
    1810                1815                1820
Glu Val Asp Gly Arg Arg Leu Val Val Ala Thr Asp Ile Ser Thr His
1825                1830                1835                1840
Ser Leu Ile Leu His Asp Leu Ile Pro Pro Pro Val Cys Arg Phe Met
                1845                1850                1855
Lys Ile Thr Val Ile Gly Arg Tyr Gly Ser Thr Asn Ala Arg Ala Lys
            1860                1865                1870
Ile Pro Leu Gly Phe Tyr Tyr Gly His Thr Tyr Ile Leu Pro Trp Glu
        1875                1880                1885
Ser Glu Leu Lys Leu Met His Asp Pro Leu Lys Gly Glu Gly Glu Ser
    1890                1895                1900
Ala Asn Gln Pro Glu Ile Asp Gln His Leu Ala Met Met Val Ala Leu
1905                1910                1915                1920
Gln Glu Asp Ile Gln Cys Arg Tyr Asn Leu Ala Cys His Arg Leu Glu
                1925                1930                1935
Thr Leu Leu Gln Ser Ile Asp Leu Pro Pro Leu Asn Ser Ala Asn Asn
            1940                1945                1950
Ala Gln Tyr Phe Leu Arg Lys Pro Asp Lys Ala Val Glu Glu Asp Ser
        1955                1960                1965
Arg Val Phe Ser Ala Tyr Gln Asp Cys Ile Gln Leu Gln Leu Gln Leu
    1970                1975                1980
Asn Leu Ala His Asn Ala Val Gln Arg Leu Lys Val Ala Leu Gly Ala
1985                1990                1995                2000
Ser Arg Lys Met Leu Ser Glu Thr Ser Asn Pro Glu Asp Leu Ile Gln
                2005                2010                2015
Thr Ser Ser Thr Glu Gln Leu Arg Thr Ile Ile Arg Tyr Leu Leu Asp
            2020                2025                2030
Thr Leu Leu Ser Leu Leu His Ala Ser Asn Gly His Ser Val Pro Ala
        2035                2040                2045
Val Leu Gln Ser Thr Phe His Ala Gln Ala Cys Glu Glu Leu Phe Lys
    2050                2055                2060
His Leu Cys Ile Ser Gly Thr Pro Lys Ile Arg Leu His Thr Gly Leu
2065                2070                2075                2080
Leu Leu Val Gln Leu Cys Gly Gly Glu Arg Trp Trp Gly Gln Phe Leu
                2085                2090                2095
Ser Asn Val Leu Gln Glu Leu Tyr Asn Ser Glu Gln Leu Leu Ile Phe
            2100                2105                2110
Pro Gln Asp Arg Val Phe Met Leu Leu Ser Cys Ile Gly Gln Arg Ser
        2115                2120                2125
Leu Ser Asn Ser Gly Val Leu Glu Ser Leu Leu Asn Leu Leu Asp Asn
    2130                2135                2140
Leu Leu Ser Pro Leu Gln Pro Gln Leu Pro Met His Arg Arg Thr Glu
2145                2150                2155                2160
Gly Val Leu Asp Ile Pro Met Ile Ser Trp Val Val Met Leu Val Ser
                2165                2170                2175
Arg Leu Leu Asp Tyr Val Ala Thr Val Glu Asp Glu Ala Ala Ala Ala
            2180                2185                2190
Lys Lys Pro Leu Asn Gly Asn Gln Trp Ser Phe Ile Asn Asn Asn Leu
        2195                2200                2205
His Thr Gln Ser Leu Asn Arg Ser Ser Lys Gly Ser Ser Ser Leu Asp
    2210                2215                2220
Arg Leu Tyr Ser Arg Lys Ile Arg Lys Gln Leu Val His His Lys Gln
2225                2230                2235                2240
Gln Leu Asn Leu Leu Lys Ala Lys Gln Lys Ala Leu Val Glu Gln Met
                2245                2250                2255
Glu Lys Glu Lys Ile Gln Ser Asn Lys Gly Ser Ser Tyr Lys Leu Leu
            2260                2265                2270
Val Glu Gln Ala Lys Leu Lys Gln Ala Thr Ser Lys His Phe Lys Asp
        2275                2280                2285
Leu Ile Arg Leu Arg Arg Thr Ala Glu Trp Ser Arg Ser Asn Leu Asp
    2290                2295                2300
Thr Glu Val Thr Thr Ala Lys Glu Ser Pro Glu Ile Glu Pro Leu Pro
2305                2310                2315                2320
Phe Thr Leu Ala His Glu Arg Cys Ile Ser Val Val Gln Lys Leu Val
                2325                2330                2335
Leu Phe Leu Leu Ser Met Asp Phe Thr Cys His Ala Asp Leu Leu Leu
            2340                2345                2350
Phe Val Cys Lys Val Leu Ala Arg Ile Ala Asn Ala Thr Arg Pro Thr
        2355                2360                2365
Ile His Leu Cys Glu Ile Val Asn Glu Pro Gln Leu Glu Arg Leu Leu
    2370                2375                2380
Leu Leu Leu Val Gly Thr Asp Phe Asn Arg Gly Asp Ile Ser Trp Gly
2385                2390                2395                2400
Gly Ala Trp Ala Gln Tyr Ser Leu Thr Cys Met Leu Gln Asp Ile Leu
                2405                2410                2415
Ala Gly Glu Leu Leu Ala Pro Val Ala Ala Glu Ala Met Glu Glu Gly
            2420                2425                2430
Thr Val Gly Asp Asp Val Gly Ala Thr Ala Gly Asp Ser Asp Asp Ser
        2435                2440                2445
Leu Gln Gln Ser Ser Val Gln Leu Leu Glu Thr Ile Asp Glu Pro Leu
    2450                2455                2460
Thr His Asp Ile Thr Gly Ala Pro Pro Leu Ser Ser Leu Glu Lys Asp
2465                2470                2475                2480
Lys Glu Ile Asp Leu Glu Leu Leu Gln Asp Leu Met Glu Val Asp Ile
                2485                2490                2495
Asp Pro Leu Asp Ile Asp Leu Glu Lys Asp Pro Leu Ala Ala Lys Val
            2500                2505                2510
Phe Lys Pro Ile Ser Ser Thr Trp Tyr Asp Tyr Trp Gly Ala Asp Tyr
        2515                2520                2525
Gly Thr Tyr Asn Tyr Asn Pro Tyr Ile Gly Gly Leu Gly Ile Pro Val
    2530                2535                2540
Ala Lys Pro Pro Ala Asn Thr Glu Lys Asn Gly Ser Gln Thr Val Ser
2545                2550                2555                2560
Val Ser Val Ser Gln Ala Leu Asp Ala Arg Leu Glu Val Gly Leu Glu
                2565                2570                2575
Gln Gln Ala Glu Leu Met Leu Lys Met Met Ser Thr Leu Glu Ala Asp
            2580                2585                2590
Ser Ile Leu Gln Ala Leu Thr Asn Thr Ser Pro Thr Leu Ser Gln Ser
        2595                2600                2605
Pro Thr Gly Thr Asp Asp Ser Leu Leu Gly Gly Leu Gln Ala Ala Asn
    2610                2615                2620
Gln Thr Ser Gln Leu Ile Ile Gln Leu Ser Ser Val Pro Met Leu Asn
2625                2630                2635                2640
Val Cys Phe Asn Lys Leu Phe Ser Met Leu Gln Val His His Val Gln
                2645                2650                2655
Leu Glu Ser Leu Leu Gln Leu Trp Leu Thr Leu Ser Leu Asn Ser Ser
            2660                2665                2670
Ser Thr Gly Asn Lys Glu Asn Gly Ala Asp Ile Phe Leu Tyr Asn Ala
        2675                2680                2685
Asn Arg Ile Pro Val Ile Ser Leu Asn Gln Ala Ser Ile Thr Ser Phe
    2690                2695                2700
Leu Thr Val Leu Ala Trp Tyr Pro Asn Thr Leu Leu Arg Thr Trp Cys
2705                2710                2715                2720
Leu Val Leu His Ser Leu Thr Leu Met Thr Asn Met Gln Leu Asn Ser
                2725                2730                2735
Gly Ser Ser Ser Ala Ile Gly Thr Gln Glu Ser Thr Ala His Leu Leu
            2740                2745                2750
Val Ser Asp Pro Asn Leu Ile His Val Leu Val Lys Phe Leu Ser Gly
        2755                2760                2765
Thr Ser Pro His Gly Thr Asn Gln His Ser Pro Gln Val Gly Pro Thr
    2770                2775                2780
Ala Thr Gln Ala Met Gln Glu Phe Leu Thr Arg Leu Gln Val His Leu
2785                2790                2795                2800
Ser Ser Thr Cys Pro Gln Ile Phe Ser Glu Phe Leu Leu Lys Leu Ile
                2805                2810                2815
His Ile Leu Ser Thr Glu Arg Gly Ala Phe Gln Thr Gly Gln Gly Pro
            2820                2825                2830
Leu Asp Ala Gln Val Lys Leu Leu Glu Phe Thr Leu Glu Gln Asn Phe
        2835                2840                2845
Glu Val Val Ser Val Ser Thr Ile Ser Ala Val Ile Glu Ser Val Thr
    2850                2855                2860
Phe Leu Val His His Tyr Ile Thr Cys Ser Asp Lys Val Met Ser Arg
2865                2870                2875                2880
Ser Gly Ser Asp Ser Ser Val Gly Ala Arg Ala Cys Phe Gly Gly Leu
                2885                2890                2895
Phe Ala Asn Leu Ile Arg Pro Gly Asp Ala Lys Ala Val Cys Gly Glu
            2900                2905                2910
Met Thr Arg Asp Gln Leu Met Phe Asp Leu Leu Lys Leu Val Asn Ile
        2915                2920                2925
Leu Val Gln Leu Pro Leu Ser Gly Asn Arg Glu Tyr Ser Ala Arg Val
    2930                2935                2940
Ser Val Thr Thr Asn Thr Thr Asp Ser Val Ser Asp Glu Glu Lys Val
2945                2950                2955                2960
Ser Gly Gly Lys Asp Gly Asn Gly Ser Ser Thr Ser Val Gln Gly Ser
                2965                2970                2975
Pro Ala Tyr Val Ala Asp Leu Val Leu Ala Asn Gln Gln Ile Met Ser
            2980                2985                2990
Gln Ile Leu Ser Ala Leu Gly Leu Cys Asn Ser Ser Ala Met Ala Met
        2995                3000                3005
Ile Ile Gly Ala Ser Gly Leu His Leu Thr Lys His Glu Asn Phe His
    3010                3015                3020
Gly Gly Leu Asp Ala Ile Ser Val Gly Asp Gly Leu Phe Thr Ile Leu
3025                3030                3035                3040
Thr Thr Leu Ser Lys Lys Ala Ser Thr Val His Met Met Leu Gln Pro
                3045                3050                3055
Ile Leu Thr Tyr Met Ala Cys Gly Tyr Met Gly Arg Gln Gly Ser Leu
            3060                3065                3070
Ala Thr Cys Gln Leu Ser Glu Pro Leu Leu Trp Phe Ile Leu Arg Val
        3075                3080                3085
Leu Asp Thr Ser Asp Ala Leu Lys Ala Phe His Asp Met Gly Gly Val
    3090                3095                3100
Gln Leu Ile Cys Asn Asn Met Val Thr Ser Thr Arg Ala Ile Val Asn
3105                3110                3115                3120
Thr Ala Arg Ser Met Val Ser Thr Ile Met Lys Phe Leu Asp Ser Gly
                3125                3130                3135
Pro Asn Lys Ala Val Asp Ser Thr Leu Lys Thr Arg Ile Leu Ala Ser
            3140                3145                3150
Glu Pro Asp Asn Ala Glu Gly Ile His Asn Phe Ala Pro Leu Gly Thr
        3155                3160                3165
Ile Thr Ser Ser Ser Pro Thr Ala Gln Pro Ala Glu Val Leu Leu Gln
    3170                3175                3180
Ala Thr Pro Pro His Arg Arg Ala Arg Ser Ala Ala Trp Ser Tyr Ile
3185                3190                3195                3200
Phe Leu Pro Glu Glu Ala Trp Cys Asp Leu Thr Ile His Leu Pro Ala
                3205                3210                3215
Ala Val Leu Leu Lys Glu Ile His Ile Gln Pro His Leu Ala Ser Leu
            3220                3225                3230
Ala Thr Cys Pro Ser Ser Val Ser Val Glu Val Ser Ala Asp Gly Val
        3235                3240                3245
Asn Met Leu Pro Leu Ser Thr Pro Val Val Thr Ser Gly Leu Thr Tyr
    3250                3255                3260
Ile Lys Ile Gln Leu Val Lys Ala Glu Val Ala Ser Ala Val Cys Leu
3265                3270                3275                3280
Arg Leu His Arg Pro Arg Asp Ala Ser Thr Leu Gly Leu Ser Gln Ile
                3285                3290                3295
Lys Leu Leu Gly Leu Thr Ala Phe Gly Thr Thr Ser Ser Ala Thr Val
            3300                3305                3310
Asn Asn Pro Phe Leu Pro Ser Glu Asp Gln Val Ser Lys Thr Ser Ile
        3315                3320                3325
Gly Trp Leu Arg Leu Leu His His Cys Leu Thr His Ile Ser Asp Leu
    3330                3335                3340
Glu Gly Met Met Ala Ser Ala Ala Ala Pro Thr Ala Asn Leu Leu Gln
3345                3350                3355                3360
Thr Cys Ala Ala Leu Leu Met Ser Pro Tyr Cys Gly Met His Ser Pro
                3365                3370                3375
Asn Ile Glu Val Val Leu Val Lys Ile Gly Leu Gln Ser Thr Arg Ile
            3380                3385                3390
Gly Leu Lys Leu Ile Asp Ile Leu Leu Arg Asn Cys Ala Ala Ser Gly
        3395                3400                3405
Ser Asp Pro Thr Asp Leu Asn Ser Pro Leu Leu Phe Gly Arg Leu Asn
    3410                3415                3420
Gly Leu Ser Ser Asp Ser Thr Ile Asp Ile Leu Tyr Gln Leu Gly Thr
3425                3430                3435                3440
Thr Gln Asp Pro Gly Thr Lys Asp Arg Ile Gln Ala Leu Leu Lys Trp
                3445                3450                3455
Val Ser Asp Ser Ala Arg Val Ala Ala Met Lys Arg Ser Gly Arg Met
            3460                3465                3470
Asn Tyr Met Cys Pro Asn Ser Ser Thr Val Glu Tyr Gly Leu Leu Met
        3475                3480                3485
Pro Ser Pro Ser His Leu His Cys Val Ala Ala Ile Leu Trp His Ser
    3490                3495                3500
Tyr Glu Leu Leu Val Glu Tyr Asp Leu Pro Ala Leu Leu Asp Gln Glu
3505                3510                3515                3520
Leu Phe Glu Leu Leu Phe Asn Trp Ser Met Ser Leu Pro Cys Asn Met
                3525                3530                3535
Val Leu Lys Lys Ala Val Asp Ser Leu Leu Cys Ser Met Cys His Val
            3540                3545                3550
His Pro Asn Tyr Phe Ser Leu Leu Met Gly Trp Met Gly Ile Thr Pro
        3555                3560                3565
Pro Pro Val Gln Cys His His Arg Leu Ser Met Thr Asp Asp Ser Lys
    3570                3575                3580
Lys Gln Asp Leu Ser Ser Ser Leu Thr Asp Asp Ser Lys Asn Ala Gln
3585                3590                3595                3600
Ala Pro Leu Ala Leu Thr Glu Ser His Leu Ala Thr Leu Ala Ser Ser
                3605                3610                3615
Ser Gln Ser Pro Glu Ala Ile Lys Gln Leu Leu Asp Ser Gly Leu Pro
            3620                3625                3630
Ser Leu Leu Val Arg Ser Leu Ala Ser Phe Cys Phe Ser His Ile Ser
        3635                3640                3645
Ser Ser Glu Ser Ile Ala Gln Ser Ile Asp Ile Ser Gln Asp Lys Leu
    3650                3655                3660
Arg Arg His His Val Pro Gln Gln Cys Asn Lys Met Pro Ile Thr Ala
3665                3670                3675                3680
Asp Leu Val Ala Pro Ile Leu Arg Phe Leu Thr Glu Val Gly Asn Ser
                3685                3690                3695
His Ile Met Lys Asp Trp Leu Gly Gly Ser Glu Val Asn Pro Leu Trp
            3700                3705                3710
Thr Ala Leu Leu Phe Leu Leu Cys His Ser Gly Ser Thr Ser Gly Ser
        3715                3720                3725
His Asn Leu Gly Ala Gln Gln Thr Ser Ala Arg Ser Ala Ser Leu Ser
    3730                3735                3740
Ser Ala Ala Thr Thr Gly Leu Thr Thr Gln Gln Arg Thr Ala Ile Glu
3745                3750                3755                3760
Asn Ala Thr Val Ala Phe Phe Leu Gln Cys Ile Ser Cys His Pro Asn
                3765                3770                3775
Asn Gln Lys Leu Met Ala Gln Val Leu Cys Glu Leu Phe Gln Thr Ser
            3780                3785                3790
Pro Gln Arg Gly Asn Leu Pro Thr Ser Gly Asn Ile Ser Gly Phe Ile
        3795                3800                3805
Arg Arg Leu Phe Leu Gln Leu Met Leu Glu Asp Glu Lys Val Thr Met
    3810                3815                3820
Phe Leu Gln Ser Pro Cys Pro Leu Tyr Lys Gly Arg Ile Asn Ala Thr
3825                3830                3835                3840
Ser His Val Ile Gln His Pro Met Tyr Gly Ala Gly His Lys Phe Arg
                3845                3850                3855
Thr Leu His Leu Pro Val Ser Thr Thr Leu Ser Asp Val Leu Asp Arg
            3860                3865                3870
Val Ser Asp Thr Pro Ser Ile Thr Ala Lys Leu Ile Ser Glu Gln Lys
        3875                3880                3885
Asp Asp Lys Glu Lys Lys Asn His Glu Glu Lys Glu Lys Val Lys Ala
    3890                3895                3900
Glu Asn Gly Phe Gln Asp Asn Tyr Ser Val Val Val Ala Ser Gly Leu
3905                3910                3915                3920
Lys Ser Gln Ser Lys Arg Ala Val Ser Ala Thr Pro Pro Arg Pro Pro
                3925                3930                3935
Ser Arg Arg Gly Arg Thr Ile Pro Asp Lys Ile Gly Ser Thr Ser Gly
            3940                3945                3950
Ala Glu Ala Ala Asn Lys Ile Ile Thr Val Pro Val Phe His Leu Phe
        3955                3960                3965
His Lys Leu Leu Ala Gly Gln Pro Leu Pro Ala Glu Met Thr Leu Ala
    3970                3975                3980
Gln Leu Leu Thr Leu Leu Tyr Asp Arg Lys Leu Pro Gln Gly Tyr Arg
3985                3990                3995                4000
Ser Ile Asp Leu Thr Val Lys Leu Gly Ser Arg Val Ile Thr Asp Pro
                4005                4010                4015
Ser Leu Ser Lys Thr Asp Ser Tyr Lys Arg Leu His Pro Glu Lys Asp
            4020                4025                4030
His Gly Asp Leu Leu Ala Ser Cys Pro Glu Asp Glu Ala Leu Thr Pro
        4035                4040                4045
Gly Asp Glu Cys Met Asp Gly Ile Leu Asp Glu Ser Leu Leu Glu Thr
    4050                4055                4060
Cys Pro Ile Gln Ser Pro Leu Gln Val Phe Ala Gly Met Gly Gly Leu
4065                4070                4075                4080
Ala Leu Ile Ala Glu Arg Leu Pro Met Leu Tyr Pro Glu Val Ile Gln
                4085                4090                4095
Gln Val Ser Ala Pro Val Val Thr Ser Thr Thr Gln Glu Lys Pro Lys
            4100                4105                4110
Asp Ser Asp Gln Phe Glu Trp Val Thr Ile Glu Gln Ser Gly Glu Leu
        4115                4120                4125
Val Tyr Glu Ala Pro Glu Thr Val Ala Ala Glu Pro Pro Pro Ile Lys
    4130                4135                4140
Ser Ala Val Gln Thr Met Ser Pro Ile Pro Ala His Ser Leu Ala Ala
4145                4150                4155                4160
Phe Gly Leu Phe Leu Arg Leu Pro Gly Tyr Ala Glu Val Leu Leu Lys
                4165                4170                4175
Glu Arg Lys His Ala Gln Cys Leu Leu Arg Leu Val Leu Gly Val Thr
            4180                4185                4190
Asp Asp Gly Glu Gly Ser His Ile Leu Gln Ser Pro Ser Ala Asn Val
        4195                4200                4205
Leu Pro Thr Leu Pro Phe His Val Leu Arg Ser Leu Phe Ser Thr Thr
    4210                4215                4220
Pro Leu Thr Thr Asp Asp Gly Val Leu Leu Arg Arg Met Ala Leu Glu
4225                4230                4235                4240
Ile Gly Ala Leu His Leu Ile Leu Val Cys Leu Ser Ala Leu Ser His
                4245                4250                4255
His Ser Pro Arg Val Pro Asn Ser Ser Val Asn Gln Thr Glu Pro Gln
            4260                4265                4270
Val Ser Ser Ser His Asn Pro Thr Ser Thr Glu Glu Gln Gln Leu Tyr
        4275                4280                4285
Trp Ala Lys Gly Thr Gly Phe Gly Thr Gly Ser Thr Ala Ser Gly Trp
    4290                4295                4300
Asp Val Glu Gln Ala Leu Thr Lys Gln Arg Leu Glu Glu Glu His Val
4305                4310                4315                4320
Thr Cys Leu Leu Gln Val Leu Ala Ser Tyr Ile Asn Pro Val Ser Ser
                4325                4330                4335
Ala Val Asn Gly Glu Ala Gln Ser Ser His Glu Thr Arg Gly Gln Asn
            4340                4345                4350
Ser Asn Ala Leu Pro Ser Val Leu Leu Glu Leu Leu Ser Gln Ser Cys
        4355                4360                4365
Leu Ile Pro Ala Met Ser Ser Tyr Leu Arg Asn Asp Ser Val Leu Asp
    4370                4375                4380
Met Ala Arg His Val Pro Leu Tyr Arg Ala Leu Leu Glu Leu Leu Arg
4385                4390                4395                4400
Ala Ile Ala Ser Cys Ala Ala Met Val Pro Leu Leu Leu Pro Leu Ser
                4405                4410                4415
Thr Glu Asn Gly Glu Glu Glu Glu Glu Gln Ser Glu Cys Gln Thr Ser
            4420                4425                4430
Val Gly Thr Leu Leu Ala Lys Met Lys Thr Cys Val Asp Thr Tyr Thr
        4435                4440                4445
Asn Arg Leu Arg Ser Lys Arg Glu Asn Val Lys Thr Gly Val Lys Pro
    4450                4455                4460
Asp Ala Ser Asp Gln Glu Pro Glu Gly Leu Thr Leu Leu Val Pro Asp
4465                4470                4475                4480
Ile Gln Lys Thr Ala Glu Ile Val Tyr Ala Ala Thr Thr Ser Leu Arg
                4485                4490                4495
Gln Ala Asn Gln Glu Lys Lys Leu Gly Glu Tyr Ser Lys Lys Ala Ala
            4500                4505                4510
Met Lys Pro Lys Pro Leu Ser Val Leu Lys Ser Leu Glu Glu Lys Tyr
        4515                4520                4525
Val Ala Val Met Lys Lys Leu Gln Phe Asp Thr Phe Glu Met Val Ser
    4530                4535                4540
Glu Asp Glu Asp Gly Lys Leu Gly Phe Lys Val Asn Tyr His Tyr Met
4545                4550                4555                4560
Ser Gln Val Lys Asn Ala Asn Asp Ala Asn Ser Ala Ala Arg Ala Arg
                4565                4570                4575
Arg Leu Ala Gln Glu Ala Val Thr Leu Ser Thr Ser Leu Pro Leu Ser
            4580                4585                4590
Ser Ser Ser Ser Val Phe Val Arg Cys Asp Glu Glu Arg Leu Asp Ile
        4595                4600                4605
Met Lys Val Leu Ile Thr Gly Pro Ala Asp Thr Pro Tyr Ala Asn Gly
    4610                4615                4620
Cys Phe Glu Phe Asp Val Tyr Phe Pro Gln Asp Tyr Pro Ser Ser Pro
4625                4630                4635                4640
Pro Leu Val Asn Leu Glu Thr Thr Gly Gly His Ser Val Arg Phe Asn
                4645                4650                4655
Pro Asn Leu Tyr Asn Asp Gly Lys Val Cys Leu Ser Ile Leu Asn Thr
            4660                4665                4670
Trp His Gly Arg Pro Glu Glu Lys Trp Asn Pro Gln Thr Ser Ser Phe
        4675                4680                4685
Leu Gln Val Leu Val Ser Val Gln Ser Leu Ile Leu Val Ala Glu Pro
    4690                4695                4700
Tyr Phe Asn Glu Pro Gly Tyr Glu Arg Ser Arg Gly Thr Pro Ser Gly
4705                4710                4715                4720
Thr Gln Ser Ser Arg Glu Tyr Asp Gly Asn Ile Arg Gln Ala Thr Val
                4725                4730                4735
Lys Trp Ala Met Leu Glu Gln Ile Arg Asn Pro Ser Pro Cys Phe Lys
            4740                4745                4750
Glu Val Ile His Lys His Phe Tyr Leu Lys Arg Val Glu Ile Met Ala
        4755                4760                4765
Gln Cys Glu Glu Trp Ile Ala Asp Ile Gln Gln Tyr Ser Ser Asp Lys
    4770                4775                4780
Arg Val Gly Arg Thr Met Ser His His Ala Ala Ala Leu Lys Arg His
4785                4790                4795                4800
Thr Ala Gln Leu Arg Glu Glu Leu Leu Lys Leu Pro Cys Pro Glu Gly
                4805                4810                4815
Leu Asp Pro Asp Thr Asp Asp Ala Pro Glu Val Cys Arg Ala Thr Thr
            4820                4825                4830
Gly Ala Glu Glu Thr Leu Met His Asp Gln Val Lys Pro Ser Ser Ser
        4835                4840                4845
Lys Glu Leu Pro Ser Asp Phe Gln Leu
    4850                4855

<210> 102
<211> 593
<212> PRT
<213> Homo sapiens

<400> 102
Met Leu Arg Thr Ser Val Leu Arg Leu Leu Gly Arg Thr Gly Ala Ser
 1               5                  10                  15
Arg Leu Ser Leu Leu Glu Asp Phe Gly Pro Arg Tyr Tyr Ser Ser Gly
            20                  25                  30
Ser Leu Ser Ala Gly Asp Asp Ala Cys Asp Val Arg Ala Tyr Phe Thr
        35                  40                  45
Thr Pro Ile Phe Tyr Val Asn Ala Ala Pro His Ile Gly His Leu Tyr
    50                  55                  60
Ser Ala Leu Leu Ala Asp Ala Leu Cys Arg His Arg Arg Leu Arg Gly
65                  70                  75                  80
Pro Ser Thr Ala Ala Thr Arg Phe Ser Thr Gly Thr Asp Glu His Gly
                85                  90                  95
Leu Lys Ile Gln Gln Ala Ala Ala Thr Ala Gly Leu Ala Pro Thr Glu
            100                 105                 110
Leu Cys Asp Arg Val Ser Glu Gln Phe Gln Gln Leu Phe Gln Glu Ala
        115                 120                 125
Gly Ile Ser Cys Thr Asp Phe Ile Arg Thr Thr Glu Ala Arg His Arg
    130                 135                 140
Val Ala Val Gln His Phe Trp Gly Val Leu Lys Ser Arg Gly Leu Leu
145                 150                 155                 160
Tyr Lys Gly Val Tyr Glu Gly Trp Tyr Cys Ala Ser Asp Glu Cys Phe
                165                 170                 175
Leu Pro Glu Ala Lys Val Thr Gln Gln Pro Gly Pro Ser Gly Asp Ser
            180                 185                 190
Phe Pro Val Ser Leu Glu Ser Gly His Pro Val Ser Trp Thr Lys Glu
        195                 200                 205
Glu Asn Tyr Ile Phe Arg Leu Ser Gln Phe Arg Lys Pro Leu Gln Arg
    210                 215                 220
Trp Leu Arg Gly Asn Pro Gln Ala Ile Thr Pro Glu Pro Phe His His
225                 230                 235                 240
Val Val Leu Gln Trp Leu Asp Glu Glu Leu Pro Asp Leu Ser Val Ser
                245                 250                 255
Arg Arg Ser Ser His Leu His Trp Gly Ile Pro Val Pro Gly Asp Asp
            260                 265                 270
Ser Gln Thr Ile Tyr Val Trp Leu Asp Ala Leu Val Asn Tyr Leu Thr
        275                 280                 285
Val Ile Gly Tyr Pro Asn Ala Glu Phe Lys Ser Trp Trp Pro Ala Thr
    290                 295                 300
Ser His Ile Ile Gly Lys Asp Ile Leu Lys Phe His Ala Ile Tyr Trp
305                 310                 315                 320
Pro Ala Phe Leu Leu Gly Ala Gly Met Ser Pro Pro Gln Arg Ile Cys
                325                 330                 335
Val His Ser His Trp Thr Val Cys Gly Gln Lys Met Ser Lys Ser Leu
            340                 345                 350
Gly Asn Val Val Asp Pro Arg Thr Cys Leu Asn Arg Tyr Thr Val Asp
        355                 360                 365
Gly Phe Arg Tyr Phe Leu Leu Arg Gln Gly Val Pro Asn Trp Asp Cys
    370                 375                 380
Asp Tyr Tyr Asp Glu Lys Val Val Lys Leu Leu Asn Ser Glu Leu Ala
385                 390                 395                 400
Asp Ala Leu Gly Gly Leu Leu Asn Arg Cys Thr Ala Lys Arg Ile Asn
                405                 410                 415
Pro Ser Glu Thr Tyr Pro Ala Phe Cys Thr Thr Cys Phe Pro Ser Glu
            420                 425                 430
Pro Gly Leu Val Gly Pro Ser Val Arg Ala Gln Ala Glu Asp Tyr Ala
        435                 440                 445
Leu Val Ser Ala Val Ala Thr Leu Pro Lys Gln Val Ala Asp His Tyr
    450                 455                 460
Asp Asn Phe Arg Ile Tyr Lys Ala Leu Glu Ala Val Ser Ser Cys Val
465                 470                 475                 480
Arg Gln Thr Asn Gly Phe Val Gln Arg His Ala Pro Trp Lys Leu Asn
                485                 490                 495
Trp Glu Ser Pro Val Asp Ala Pro Trp Leu Gly Thr Val Leu His Val
            500                 505                 510
Ala Leu Glu Cys Leu Arg Val Phe Gly Thr Leu Leu Gln Pro Val Thr
        515                 520                 525
Pro Ser Leu Ala Asp Lys Leu Leu Ser Arg Leu Gly Val Ser Ala Ser
    530                 535                 540
Glu Arg Ser Leu Gly Glu Leu Tyr Phe Leu Pro Arg Phe Tyr Gly His
545                 550                 555                 560
Pro Cys Pro Phe Glu Gly Arg Arg Leu Gly Pro Glu Thr Gly Leu Leu
                565                 570                 575
Phe Pro Arg Leu Asp Gln Ser Arg Thr Trp Leu Val Lys Ala His Arg
            580                 585                 590
Thr


<210> 103
<211> 377
<212> PRT
<213> Homo sapiens

<400> 103
Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser
 1               5                  10                  15
Arg Ser Ala Ile Thr Ala Ile Ala Thr Ser Val Cys His Gly Pro Pro
            20                  25                  30
Cys Arg Gln Leu His His Ala Leu Met Pro His Gly Lys Gly Gly Arg
        35                  40                  45
Ser Ser Val Ser Gly Ile Val Ala Thr Val Phe Gly Ala Thr Gly Phe
    50                  55                  60
Leu Gly Arg Tyr Val Val Asn His Leu Gly Arg Met Gly Ser Gln Val
65                  70                  75                  80
Ile Ile Pro Tyr Arg Cys Asp Lys Tyr Asp Ile Met His Leu Arg Pro
                85                  90                  95
Met Gly Asp Leu Gly Gln Leu Leu Phe Leu Glu Trp Asp Ala Arg Asp
            100                 105                 110
Lys Asp Ser Ile Arg Arg Val Val Gln His Ser Asn Val Val Ile Asn
        115                 120                 125
Leu Ile Gly Arg Asp Trp Glu Thr Lys Asn Phe Asp Phe Glu Asp Val
    130                 135                 140
Phe Val Lys Ile Pro Gln Ala Ile Ala Gln Leu Ser Lys Glu Ala Gly
145                 150                 155                 160
Val Glu Lys Phe Ile His Val Ser His Leu Asn Ala Asn Ile Lys Ser
                165                 170                 175
Ser Ser Arg Tyr Leu Arg Asn Lys Ala Val Gly Glu Lys Val Val Arg
            180                 185                 190
Asp Ala Phe Pro Glu Ala Ile Ile Val Lys Pro Ser Asp Ile Phe Gly
        195                 200                 205
Arg Glu Asp Arg Phe Leu Asn Ser Phe Ala Ser Met His Arg Phe Gly
    210                 215                 220
Pro Ile Pro Leu Gly Ser Leu Gly Trp Lys Thr Val Lys Gln Pro Val
225                 230                 235                 240
Tyr Val Val Asp Val Ser Lys Gly Ile Val Asn Ala Val Lys Asp Pro
                245                 250                 255
Asp Ala Asn Gly Lys Ser Phe Ala Phe Val Gly Pro Ser Arg Tyr Leu
            260                 265                 270
Leu Phe His Leu Val Lys Tyr Ile Phe Ala Val Ala His Arg Leu Phe
        275                 280                 285
Leu Pro Phe Pro Leu Pro Leu Phe Ala Tyr Arg Trp Val Ala Arg Val
    290                 295                 300
Phe Glu Ile Ser Pro Phe Glu Pro Trp Ile Thr Arg Asp Lys Val Glu
305                 310                 315                 320
Arg Met His Ile Thr Asp Met Lys Leu Pro His Leu Pro Gly Leu Glu
                325                 330                 335
Asp Leu Gly Ile Gln Ala Thr Pro Leu Glu Leu Lys Ala Ile Glu Val
            340                 345                 350
Leu Arg Arg His Arg Thr Tyr Arg Trp Leu Ser Ala Glu Ile Glu Asp
        355                 360                 365
Val Lys Pro Ala Lys Thr Val Asn Ile
    370                 375

<210> 104
<211> 1318
<212> PRT
<213> Homo sapiens

<400> 104
Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly
 1               5                  10                  15
Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln
            20                  25                  30
Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val
        35                  40                  45
Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser
    50                  55                  60
Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu
65                  70                  75                  80
Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln
                85                  90                  95
Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro
            100                 105                 110
Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile
        115                 120                 125
Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp
    130                 135                 140
Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln
145                 150                 155                 160
Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys
                165                 170                 175
Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys
            180                 185                 190
Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln
        195                 200                 205
Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu
    210                 215                 220
Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn
225                 230                 235                 240
Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp
                245                 250                 255
Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu
            260                 265                 270
Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp
        275                 280                 285
Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys
    290                 295                 300
Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe
305                 310                 315                 320
Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro
                325                 330                 335
Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn
            340                 345                 350
Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile
        355                 360                 365
Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu
    370                 375                 380
Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly
385                 390                 395                 400
Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu
                405                 410                 415
Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala
            420                 425                 430
Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met
        435                 440                 445
Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro
    450                 455                 460
Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser
465                 470                 475                 480
Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe
                485                 490                 495
Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile
            500                 505                 510
Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg
        515                 520                 525
Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly
    530                 535                 540
Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly
545                 550                 555                 560
Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser
                565                 570                 575
Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe
            580                 585                 590
Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln
        595                 600                 605
Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu
    610                 615                 620
Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser
625                 630                 635                 640
Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys
                645                 650                 655
Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu
            660                 665                 670
Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe
        675                 680                 685
Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser
    690                 695                 700
Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser
705                 710                 715                 720
Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn
                725                 730                 735
Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser
            740                 745                 750
Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala
        755                 760                 765
Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro
    770                 775                 780
Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser
785                 790                 795                 800
Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr
                805                 810                 815
Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu
            820                 825                 830
Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala
        835                 840                 845
Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala
    850                 855                 860
Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met
865                 870                 875                 880
Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly
                885                 890                 895
Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu
            900                 905                 910
Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg
        915                 920                 925
Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile
    930                 935                 940
Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro
945                 950                 955                 960
Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln
                965                 970                 975
His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr
            980                 985                 990
Lys Ile Asp Ser Ser Asn Arg Glu Gln Arg Leu Glu Asp Lys Gly Asp
        995                 1000                1005
Thr Pro Leu Glu Leu Gly Asp Asp Cys Ser Leu Ala Leu Val Trp Arg
    1010                1015                1020
Asn Asn Glu Arg Leu Gln Glu Phe Val Leu Val Ala Ser Lys Glu Leu
1025                1030                1035                1040
Glu Cys Ala Glu Asp Pro Gly Ser Ala Gly Glu Ala Ala Arg Ala Gly
                1045                1050                1055
His Phe Thr Leu Asp Gln Cys Leu Asn Leu Phe Thr Arg Pro Glu Val
            1060                1065                1070
Leu Ala Pro Glu Glu Ala Trp Tyr Cys Pro Gln Cys Lys Gln His Arg
        1075                1080                1085
Glu Ala Ser Lys Gln Leu Leu Leu Trp Arg Leu Pro Asn Val Leu Ile
    1090                1095                1100
Val Gln Leu Lys Arg Phe Ser Phe Arg Ser Phe Ile Trp Arg Asp Lys
1105                1110                1115                1120
Ile Asn Asp Leu Val Glu Phe Pro Val Arg Asn Leu Asp Leu Ser Lys
                1125                1130                1135
Phe Cys Ile Gly Gln Lys Glu Glu Gln Leu Pro Ser Tyr Asp Leu Tyr
            1140                1145                1150
Ala Val Ile Asn His Tyr Gly Gly Met Ile Gly Gly His Tyr Thr Ala
        1155                1160                1165
Cys Ala Arg Leu Pro Asn Asp Arg Ser Ser Gln Arg Ser Asp Val Gly
    1170                1175                1180
Trp Arg Leu Phe Asp Asp Ser Thr Val Thr Thr Val Asp Glu Ser Gln
1185                1190                1195                1200
Val Val Thr Arg Tyr Ala Tyr Val Leu Phe Tyr Arg Arg Arg Asn Ser
                1205                1210                1215
Pro Val Glu Arg Pro Pro Arg Ala Gly His Ser Glu His His Pro Asp
            1220                1225                1230
Leu Gly Pro Ala Ala Glu Ala Ala Ala Ser Gln Ala Ser Arg Ile Trp
        1235                1240                1245
Gln Glu Leu Glu Ala Glu Glu Glu Pro Val Pro Glu Gly Ser Gly Pro
    1250                1255                1260
Leu Gly Pro Trp Gly Pro Gln Asp Trp Val Gly Pro Leu Pro Arg Gly
1265                1270                1275                1280
Pro Thr Thr Pro Asp Glu Gly Cys Leu Arg Tyr Phe Val Leu Gly Thr
                1285                1290                1295
Val Ala Ala Leu Val Ala Leu Val Leu Asn Val Phe Tyr Pro Leu Val
            1300                1305                1310
Ser Gln Ser Arg Trp Arg
        1315

<210> 105
<211> 1052
<212> PRT
<213> Homo sapiens

<400> 105
Met Glu Gly Ser Glu Pro Val Ala Ala His Gln Gly Glu Glu Ala Ser
 1               5                  10                  15
Cys Ser Ser Trp Gly Thr Gly Ser Thr Asn Lys Asn Leu Pro Ile Met
            20                  25                  30
Ser Thr Ala Ser Val Glu Ile Asp Asp Ala Leu Tyr Ser Arg Gln Arg
        35                  40                  45
Tyr Val Leu Gly Asp Thr Ala Met Gln Lys Met Ala Lys Ser His Val
    50                  55                  60
Phe Leu Ser Gly Met Gly Gly Leu Gly Leu Glu Ile Ala Lys Asn Leu
65                  70                  75                  80
Val Leu Ala Gly Ile Lys Ala Val Thr Ile His Asp Thr Glu Lys Cys
                85                  90                  95
Gln Ala Trp Asp Leu Gly Thr Asn Phe Phe Leu Ser Glu Asp Asp Val
            100                 105                 110
Val Asn Lys Arg Asn Arg Ala Glu Ala Val Leu Lys His Ile Ala Glu
        115                 120                 125
Leu Asn Pro Tyr Val His Val Thr Ser Ser Ser Val Pro Phe Asn Glu
    130                 135                 140
Thr Thr Asp Leu Ser Phe Leu Asp Lys Tyr Gln Cys Val Val Leu Thr
145                 150                 155                 160
Glu Met Lys Leu Pro Leu Gln Lys Lys Ile Asn Asp Phe Cys Arg Ser
                165                 170                 175
Gln Cys Pro Pro Ile Lys Phe Ile Ser Ala Asp Val His Gly Ile Trp
            180                 185                 190
Ser Arg Leu Phe Cys Asp Phe Gly Asp Glu Phe Glu Val Leu Asp Thr
        195                 200                 205
Thr Gly Glu Glu Pro Lys Glu Ile Phe Ile Ser Asn Ile Thr Gln Ala
    210                 215                 220
Asn Pro Gly Ile Val Thr Cys Leu Glu Asn His Pro His Lys Leu Glu
225                 230                 235                 240
Thr Gly Gln Phe Leu Thr Phe Arg Glu Ile Asn Gly Met Thr Gly Leu
                245                 250                 255
Asn Gly Ser Ile Gln Gln Ile Thr Val Ile Ser Pro Phe Ser Phe Ser
            260                 265                 270
Ile Gly Asp Thr Thr Glu Leu Glu Pro Tyr Leu His Gly Gly Ile Ala
        275                 280                 285
Val Gln Val Lys Thr Pro Lys Thr Val Phe Phe Glu Ser Leu Glu Arg
    290                 295                 300
Gln Leu Lys His Pro Lys Cys Leu Ile Val Asp Phe Ser Asn Pro Glu
305                 310                 315                 320
Ala Pro Leu Glu Ile His Thr Ala Met Leu Ala Leu Asp Gln Phe Gln
                325                 330                 335
Glu Lys Tyr Ser Arg Lys Pro Asn Val Gly Cys Gln Gln Asp Ser Glu
            340                 345                 350
Glu Leu Leu Lys Leu Ala Thr Ser Ile Ser Glu Thr Leu Glu Glu Lys
        355                 360                 365
Pro Asp Val Asn Ala Asp Ile Val His Trp Leu Ser Trp Thr Ala Gln
    370                 375                 380
Gly Phe Leu Ser Pro Leu Ala Ala Ala Val Gly Gly Val Ala Ser Gln
385                 390                 395                 400
Glu Val Leu Lys Ala Val Thr Gly Lys Phe Ser Pro Leu Cys Gln Trp
                405                 410                 415
Leu Tyr Leu Glu Ala Ala Asp Ile Val Glu Ser Leu Gly Lys Pro Glu
            420                 425                 430
Cys Glu Glu Phe Leu Pro Arg Gly Asp Arg Tyr Asp Ala Leu Arg Ala
        435                 440                 445
Cys Ile Gly Asp Thr Leu Cys Gln Lys Leu Gln Asn Leu Asn Ile Phe
    450                 455                 460
Leu Val Gly Cys Gly Ala Ile Gly Cys Glu Met Leu Lys Asn Phe Ala
465                 470                 475                 480
Leu Leu Gly Val Gly Thr Ser Lys Glu Lys Gly Met Ile Thr Val Thr
                485                 490                 495
Asp Pro Asp Leu Ile Glu Lys Ser Asn Leu Asn Arg Gln Phe Leu Phe
            500                 505                 510
Arg Pro His His Ile Gln Lys Pro Lys Ser Tyr Thr Ala Ala Asp Ala
        515                 520                 525
Thr Leu Lys Ile Asn Ser Gln Ile Lys Ile Asp Ala His Leu Asn Lys
    530                 535                 540
Val Cys Pro Thr Thr Glu Thr Ile Tyr Asn Asp Glu Phe Tyr Thr Lys
545                 550                 555                 560
Gln Asp Val Ile Ile Thr Ala Leu Asp Asn Val Glu Ala Arg Arg Tyr
                565                 570                 575
Val Asp Ser Arg Cys Leu Ala Asn Leu Arg Pro Leu Leu Asp Ser Gly
            580                 585                 590
Thr Met Gly Thr Lys Gly His Thr Glu Val Ile Val Pro His Leu Thr
        595                 600                 605
Glu Ser Tyr Asn Ser His Arg Asp Pro Pro Glu Glu Glu Ile Pro Phe
    610                 615                 620
Cys Thr Leu Lys Ser Phe Pro Ala Ala Ile Glu His Thr Ile Gln Trp
625                 630                 635                 640
Ala Arg Asp Lys Phe Glu Ser Ser Phe Ser His Lys Pro Ser Leu Phe
                645                 650                 655
Asn Lys Phe Trp Gln Thr Tyr Ser Ser Ala Glu Glu Val Leu Gln Lys
            660                 665                 670
Ile Gln Ser Gly His Ser Leu Glu Gly Cys Phe Gln Val Ile Lys Leu
        675                 680                 685
Leu Ser Arg Arg Pro Arg Asn Trp Ser Gln Cys Val Glu Leu Ala Arg
    690                 695                 700
Leu Lys Phe Glu Lys Tyr Phe Asn His Lys Ala Leu Gln Leu Leu His
705                 710                 715                 720
Cys Phe Pro Leu Asp Ile Arg Leu Lys Asp Gly Ser Leu Phe Trp Gln
                725                 730                 735
Ser Pro Lys Arg Pro Pro Ser Pro Ile Lys Phe Asp Leu Asn Glu Pro
            740                 745                 750
Leu His Leu Ser Phe Leu Gln Asn Ala Ala Lys Leu Tyr Ala Thr Val
        755                 760                 765
Tyr Cys Ile Pro Phe Ala Glu Glu Asp Leu Ser Ala Asp Ala Leu Leu
    770                 775                 780
Asn Ile Leu Ser Glu Val Lys Ile Gln Glu Phe Lys Pro Ser Asn Lys
785                 790                 795                 800
Val Val Gln Thr Asp Glu Thr Ala Arg Lys Pro Asp His Val Pro Ile
                805                 810                 815
Ser Ser Glu Asp Glu Arg Asn Ala Ile Phe Gln Leu Glu Lys Ala Ile
            820                 825                 830
Leu Ser Asn Glu Ala Thr Lys Ser Asp Leu Gln Met Ala Val Leu Ser
        835                 840                 845
Phe Glu Lys Asp Asp Asp His Asn Gly His Ile Asp Phe Ile Thr Ala
    850                 855                 860
Ala Ser Asn Leu Arg Ala Lys Met Tyr Ser Ile Glu Pro Ala Asp Arg
865                 870                 875                 880
Phe Lys Thr Lys Arg Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr
                885                 890                 895
Thr Thr Ala Thr Val Ser Gly Leu Val Ala Leu Glu Met Ile Lys Val
            900                 905                 910
Thr Gly Gly Tyr Pro Phe Glu Ala Tyr Lys Asn Cys Phe Leu Asn Leu
        915                 920                 925
Ala Ile Pro Ile Val Val Phe Thr Glu Thr Thr Glu Val Arg Lys Thr
    930                 935                 940
Lys Ile Arg Asn Gly Ile Ser Phe Thr Ile Trp Asp Arg Trp Thr Val
945                 950                 955                 960
His Gly Lys Glu Asp Phe Thr Leu Leu Asp Phe Ile Asn Ala Val Lys
                965                 970                 975
Glu Lys Tyr Gly Ile Glu Pro Thr Met Val Val Gln Gly Val Lys Met
            980                 985                 990
Leu Tyr Val Pro Val Met Pro Gly His Ala Lys Arg Leu Lys Leu Thr
        995                 1000                1005
Met His Lys Leu Val Lys Pro Thr Thr Glu Lys Lys Tyr Val Asp Leu
    1010                1015                1020
Thr Val Ser Phe Ala Pro Asp Ile Asp Gly Asp Glu Asp Leu Pro Gly
1025                1030                1035                1040
Pro Pro Val Arg Tyr Tyr Phe Ser His Asp Thr Asp
                1045                1050

<210> 106
<211> 334
<212> PRT
<213> Homo sapiens

<400> 106
Met Arg Leu Thr Pro Arg Ala Leu Cys Ser Ala Ala Gln Ala Ala Trp
 1               5                  10                  15
Arg Glu Asn Phe Pro Leu Cys Gly Arg Asp Val Ala Arg Trp Phe Pro
            20                  25                  30
Gly His Met Ala Lys Gly Leu Lys Lys Met Gln Ser Ser Leu Lys Leu
        35                  40                  45
Val Asp Cys Ile Ile Glu Val His Asp Ala Arg Ile Pro Leu Ser Gly
    50                  55                  60
Arg Asn Pro Leu Phe Gln Glu Thr Leu Gly Leu Lys Pro His Leu Leu
65                  70                  75                  80
Val Leu Asn Lys Met Asp Leu Ala Asp Leu Thr Glu Gln Gln Lys Ile
                85                  90                  95
Met Gln His Leu Glu Gly Glu Gly Leu Lys Asn Val Ile Phe Thr Asn
            100                 105                 110
Cys Val Lys Asp Glu Asn Val Lys Gln Ile Ile Pro Met Val Thr Glu
        115                 120                 125
Leu Ile Gly Arg Ser His Arg Tyr His Arg Lys Glu Asn Leu Glu Tyr
    130                 135                 140
Cys Ile Met Val Ile Gly Val Pro Asn Val Gly Lys Ser Ser Leu Ile
145                 150                 155                 160
Asn Ser Leu Arg Arg Gln His Leu Arg Lys Gly Lys Ala Thr Arg Val
                165                 170                 175
Gly Gly Glu Pro Gly Ile Thr Arg Ala Val Met Ser Lys Ile Gln Val
            180                 185                 190
Ser Glu Arg Pro Leu Met Phe Leu Leu Asp Thr Pro Gly Val Leu Ala
        195                 200                 205
Pro Arg Ile Glu Ser Val Glu Thr Gly Leu Lys Leu Ala Leu Cys Gly
    210                 215                 220
Thr Val Leu Asp His Leu Val Gly Glu Glu Thr Met Ala Asp Tyr Leu
225                 230                 235                 240
Leu Tyr Thr Leu Asn Lys His Gln Arg Phe Gly Tyr Val Gln His Tyr
                245                 250                 255
Gly Leu Gly Ser Ala Cys Asp Asn Val Glu Arg Val Leu Lys Ser Val
            260                 265                 270
Ala Val Lys Leu Gly Lys Thr Gln Lys Val Lys Val Leu Thr Gly Thr
        275                 280                 285
Gly Asn Val Asn Ile Ile Gln Pro Asn Tyr Pro Ala Ala Ala Arg Asp
    290                 295                 300
Phe Leu Gln Thr Phe Arg Arg Gly Leu Leu Gly Ser Val Met Leu Asp
305                 310                 315                 320
Leu Asp Val Leu Arg Gly His Pro Pro Ala Glu Thr Leu Pro
                325                 330

<210> 107
<211> 583
<212> PRT
<213> Homo sapiens

<400> 107
Met Thr Phe Tyr Leu Phe Gly Ile Arg Ser Phe Pro Lys Leu Trp Lys
 1               5                  10                  15
Ser Pro Tyr Leu Gly Leu Gly Pro Gly His Ser Tyr Val Ser Leu Phe
            20                  25                  30
Leu Ala Asp Arg Cys Gly Ile Arg Asn Gln Gln Arg Leu Phe Ser Leu
        35                  40                  45
Lys Thr Met Ser Pro Gln Asn Thr Lys Ala Thr Asn Leu Ile Ala Lys
    50                  55                  60
Ala Arg Tyr Leu Arg Lys Asp Glu Gly Ser Asn Lys Gln Val Tyr Ser
65                  70                  75                  80
Val Pro His Phe Phe Leu Ala Gly Ala Ala Lys Glu Arg Ser Gln Met
                85                  90                  95
Asn Ser Gln Thr Glu Asp His Ala Leu Ala Pro Val Arg Asn Thr Ile
            100                 105                 110
Gln Leu Pro Thr Gln Pro Leu Asn Ser Glu Glu Trp Asp Lys Leu Lys
        115                 120                 125
Glu Asp Leu Lys Glu Asn Thr Gly Lys Thr Ser Phe Glu Ser Trp Ile
    130                 135                 140
Ile Ser Gln Met Ala Gly Cys His Ser Ser Ile Asp Val Ala Lys Ser
145                 150                 155                 160
Leu Leu Ala Trp Val Ala Ala Lys Asn Asn Gly Ile Val Ser Tyr Asp
                165                 170                 175
Leu Leu Val Lys Tyr Leu Tyr Leu Cys Val Phe His Met Gln Thr Ser
            180                 185                 190
Glu Val Ile Asp Val Phe Glu Ile Met Lys Ala Arg Tyr Lys Thr Leu
        195                 200                 205
Glu Pro Arg Gly Tyr Ser Leu Leu Ile Arg Gly Leu Ile His Ser Asp
    210                 215                 220
Arg Trp Arg Glu Ala Leu Leu Leu Leu Glu Asp Ile Lys Lys Val Ile
225                 230                 235                 240
Thr Pro Ser Lys Lys Asn Tyr Asn Asp Cys Ile Gln Gly Ala Leu Leu
                245                 250                 255
His Gln Asp Val Asn Thr Ala Trp Asn Leu Tyr Gln Glu Leu Leu Gly
            260                 265                 270
His Asp Ile Val Pro Met Leu Glu Thr Leu Lys Ala Phe Phe Asp Phe
        275                 280                 285
Gly Lys Asp Ile Lys Asp Asp Asn Tyr Ser Asn Lys Leu Leu Asp Ile
    290                 295                 300
Leu Ser Tyr Leu Arg Asn Asn Gln Leu Tyr Pro Gly Glu Ser Phe Ala
305                 310                 315                 320
His Ser Ile Lys Thr Trp Phe Glu Ser Val Pro Gly Lys Gln Trp Lys
                325                 330                 335
Gly Gln Phe Thr Thr Val Arg Lys Ser Gly Gln Cys Ser Gly Cys Gly
            340                 345                 350
Lys Thr Ile Glu Ser Ile Gln Leu Ser Pro Glu Glu Tyr Glu Cys Leu
        355                 360                 365
Lys Gly Lys Ile Met Arg Asp Val Ile Asp Gly Gly Asp Gln Tyr Arg
    370                 375                 380
Lys Thr Thr Pro Gln Glu Leu Lys Arg Phe Glu Asn Phe Ile Lys Ser
385                 390                 395                 400
Arg Pro Pro Phe Asp Val Val Ile Asp Gly Leu Asn Val Ala Lys Met
                405                 410                 415
Phe Pro Lys Val Arg Glu Ser Gln Leu Leu Leu Asn Val Val Ser Gln
            420                 425                 430
Leu Ala Lys Arg Asn Leu Arg Leu Leu Val Leu Gly Arg Lys His Met
        435                 440                 445
Leu Arg Arg Ser Ser Gln Trp Ser Arg Asp Glu Met Glu Glu Val Gln
    450                 455                 460
Lys Gln Ala Ser Cys Phe Phe Ala Asp Asp Ile Ser Glu Asp Asp Pro
465                 470                 475                 480
Phe Leu Leu Tyr Ala Thr Leu His Ser Gly Asn His Cys Arg Phe Ile
                485                 490                 495
Thr Arg Asp Leu Met Arg Asp His Lys Ala Cys Leu Pro Asp Ala Lys
            500                 505                 510
Thr Gln Arg Leu Phe Phe Lys Trp Gln Gln Gly His Gln Leu Ala Ile
        515                 520                 525
Val Asn Arg Phe Pro Gly Ser Lys Leu Thr Phe Gln Arg Ile Leu Ser
    530                 535                 540
Tyr Asp Thr Val Val Gln Thr Thr Gly Asp Ser Trp His Ile Pro Tyr
545                 550                 555                 560
Asp Glu Asp Leu Val Glu Arg Cys Ser Cys Glu Val Pro Thr Lys Trp
                565                 570                 575
Leu Cys Leu His Gln Lys Thr
            580

<210> 108
<211> 393
<212> PRT
<213> Homo sapiens

<400> 108
Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val
 1               5                  10                  15
Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp
            20                  25                  30
Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln
        35                  40                  45
Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile
    50                  55                  60
Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp
65                  70                  75                  80
Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu
                85                  90                  95
Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr
            100                 105                 110
Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys
        115                 120                 125
Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu
    130                 135                 140
Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln
145                 150                 155                 160
Asp Ser Leu Asn Asn Glu Glu Glu Gly Ala Ser Gly Gly Ala Val His
                165                 170                 175
Ser Asp Ile Gly Ser Ser Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu
            180                 185                 190
Val Thr Asp Thr Thr Glu Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu
        195                 200                 205
Glu Phe Leu Leu Pro Pro Glu Pro Asp Tyr Ser Leu Leu Leu Thr Phe
    210                 215                 220
Ile Tyr Asn Gly Arg Val Val Gly Glu Ala Gln Val Gln Ser Leu Asp
225                 230                 235                 240
Cys Arg Leu Val Ala Glu Pro Ser Gly Ser Glu Ser Ser Met Glu Gln
                245                 250                 255
Val Leu Phe Pro Lys Pro Gly Pro Leu Glu Pro Thr Gln Arg Leu Leu
            260                 265                 270
Ser Gln Leu Glu Arg Gly Ile Leu Val Ala Ser Asn Pro Arg Gly Leu
        275                 280                 285
Phe Val Gln Arg Leu Cys Pro Ile Pro Ile Ser Trp Asn Ala Pro Gln
    290                 295                 300
Ala Pro Pro Gly Pro Gly Pro His Leu Leu Pro Ser Asn Glu Cys Val
305                 310                 315                 320
Glu Leu Phe Arg Thr Ala Tyr Phe Cys Arg Asp Leu Val Arg Tyr Phe
                325                 330                 335
Gln Gly Leu Gly Pro Pro Pro Lys Phe Gln Val Thr Leu Asn Phe Trp
            340                 345                 350
Glu Glu Ser His Gly Ser Ser His Thr Pro Gln Asn Leu Ile Thr Val
        355                 360                 365
Lys Met Glu Gln Ala Phe Ala Arg Tyr Leu Leu Glu Gln Thr Pro Glu
    370                 375                 380
Gln Gln Ala Ala Ile Leu Ser Leu Val
385                 390

<210> 109
<211> 9
<212> RNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 109
uucaagaga                                                               9

<210> 110
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 110
gggagccggt tacttcctg                                                   19

<210> 111
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 111
cttcttcagg agcgcccag                                                   19

<210> 112
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 112
tcttggaagt aacagcggt                                                   19

<210> 113
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 113
agagttgaga gaaatggca                                                   19

<210> 114
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 114
acgtcacagc ctctgacag                                                   19

<210> 115
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 115
tgctgcttct tgggggagc                                                   19

<210> 116
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 116
gcgggatggc atcactgca                                                   19

<210> 117
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 117
tgtgcactgg tctcaggta                                                   19

<210> 118
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 118
cagtccagtc aatagggat                                                   19

<210> 119
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 119
ctggggctac tgacgcgcg                                                   19

<210> 120
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 120
tgcctgtttg ttccggagc                                                   19

<210> 121
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 121
cagggcggcg atccacctc                                                   19

<210> 122
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 122
tctccatgcc tgatgcaga                                                   19

<210> 123
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 123
agacacttcg gaccctccg                                                   19

<210> 124
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 124
gggtacgggg catatgccg                                                   19

<210> 125
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 125
cacccccgtg gtcgcagaa                                                   19

<210> 126
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 126
acagggttgc atcactagc                                                   19

<210> 127
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 127
gttgatgtga agggttaca                                                   19

<210> 128
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 128
ctaggccgat acaaagcag                                                   19

<210> 129
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 129
cacgtcctcg ataccccca                                                   19

<210> 130
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 130
cacctcctcg atatctggc                                                   19

<210> 131
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 131
gctagcgaag ttctccgtg                                                   19

<210> 132
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 132
agggaacttc tgatggtac                                                   19

<210> 133
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 133
tagaaaactc caagataaa                                                   19

<210> 134
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 134
ggaagcatgc tgccaagca                                                   19

<210> 135
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 135
ttcgcaatct tgggatcaa                                                   19

<210> 136
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 136
agccgagatg ctaagagca                                                   19

<210> 137
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 137
atactcgtgc gtttggcgt                                                   19

<210> 138
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 138
cctcgtggct ggccccgag                                                   19

<210> 139
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 139
tatccgcaca tcgccgtca                                                   19

<210> 140
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 140
cgattctctc actgagccg                                                   19

<210> 141
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 141
tttgactgat gagtccact                                                   19

<210> 142
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 142
aggtttcata cacagtcca                                                   19

<210> 143
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 143
ttcttccaac tgtccttgc                                                   19

<210> 144
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 144
gttagagacg ctattccgc                                                   19

<210> 145
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 145
cccccggccg cacacctga                                                   19

<210> 146
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 146
aagagcttga tagtaacaa                                                   19

<210> 147
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 147
atgaggggcc atgaagacg                                                   19

<210> 148
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 148
ttccccccga atcccagcg                                                   19

<210> 149
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 149
ttaatagcaa caaatagag                                                   19

<210> 150
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 150
tgcttcttgt cggcttgaa                                                   19

<210> 151
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 151
gaggtctcgg acagcgagt                                                   19

<210> 152
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 152
tccatcagat gcttgtacg                                                   19

<210> 153
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 153
cgttaggtac ctgtgcgaa                                                   19

<210> 154
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 154
agcccctcat ttcaatgag                                                   19

<210> 155
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 155
tgtatcagtt gctgccacc                                                   19

<210> 156
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 156
gcccctgaaa attctcccc                                                   19

<210> 157
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 157
acgaggagac tcactcggg                                                   19

<210> 158
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 158
cgggtcgaag gcttcatag                                                   19

<210> 159
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 159
gtgtgcatgc tagtaactg                                                   19

<210> 160
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 160
tgaagtctcg ttgaaactg                                                   19

<210> 161
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 161
tggtgctgga cgtcggctc                                                   19

<210> 162
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 162
atccgcctac cccgctcca                                                   19

<210> 163
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 163
ggacttgtag ggatgcacc                                                   19

<210> 164
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 164
agcactggct cagagggtc                                                   19

<210> 165
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 165
ctccacgatg accgtgccc                                                   19

<210> 166
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 166
tcacgctggt cgactgccc                                                   19

<210> 167
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 167
atgagtacat tgccgcgct                                                   19

<210> 168
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 168
tcaccacgtg cttgggtac                                                   19

<210> 169
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 169
ccgtgacctc caaggcgag                                                   19

<210> 170
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 170
gccgtgagct acatgtcgc                                                   19

<210> 171
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 171
accattggcg tggatccgc                                                   19

<210> 172
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 172
agtcacgtgt cctaccgtc                                                   19

<210> 173
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 173
gtatgggaac taatgtcgc                                                   19

<210> 174
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 174
tattctaccc atgctgccc                                                   19

<210> 175
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 175
gcaaaagatg cctgcctga                                                   19

<210> 176
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 176
cacgtcacct tggagccga                                                   19

<210> 177
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 177
aatctcttac tgaagctgc                                                   19

<210> 178
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 178
cgactctacc ccgtgctgc                                                   19

<210> 179
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 179
cgactcggtg cacctcgcc                                                   19

<210> 180
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 180
ggggggttcg tagcagagc                                                   19

<210> 181
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 181
cagctcgtct acacctgca                                                   19

<210> 182
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 182
gcactcacgt ctctggcgc                                                   19

<210> 183
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 183
cggttccagt ctctcggtg                                                   19

<210> 184
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 184
gcacggtgct caccacgtc                                                   19

<210> 185
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 185
attccatcta tggctccac                                                   19

<210> 186
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 186
tcatccggac catcatcgg                                                   19

<210> 187
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 187
accccagctg tgcaccggt                                                   19

<210> 188
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 188
actatttctg tagtaccaa                                                   19

<210> 189
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 189
tgctcgactt ttccggcca                                                   19

<210> 190
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 190
cacctgcgca acctcgccg                                                   19

<210> 191
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 191
caagtgagta gagaagatc                                                   19

<210> 192
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 192
agcagaaacg tgtcctccg                                                   19

<210> 193
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 193
cgctagtccc acccgcgga                                                   19

<210> 194
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 194
tgcgatcacc actggcccg                                                   19

<210> 195
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 195
acttctgtca ccgccttgc                                                   19

<210> 196
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 196
cacgcaaggc cacggtgcc                                                   19

<210> 197
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 197
cagtacgtca tgctctcgg                                                   19

<210> 198
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 198
agcatctcat acacacgcg                                                   19

<210> 199
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 199
cctcggaact cacggcatg                                                   19

<210> 200
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 200
tggctctggg tcggttgga                                                   19

<210> 201
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 201
accaaagctt ctgtcaggc                                                   19

<210> 202
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 202
gccttcctct tcgtcggcg                                                   19

<210> 203
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 203
caggtctgaa gcgcctgac                                                   19

<210> 204
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 204
gaccgattcc gtggagtgc                                                   19

<210> 205
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 205
caacctcacg accggatca                                                   19

<210> 206
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 206
agcatctccg ctcatggca                                                   19

<210> 207
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 207
ggcctgggtc gtcgcgacc                                                   19

<210> 208
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 208
gccagcacac actcatgcc                                                   19

<210> 209
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 209
agacagccag catttccat                                                   19

<210> 210
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 210
ttgccacagg aagtaaccg                                                   19

<210> 211
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 211
ccagtacttg actcgtggag                                                  20

<210> 212
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 212
ttaacaaggt ggagcctcat c                                                21

<210> 213
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 213
ggcagattgg agagaagagg                                                  20

<210> 214
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 214
gccccacgac aataaactg                                                   19

<210> 215
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 215
acagagcctc gcctttg                                                     17

<210> 216
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 216
ccttgcacat gccggag                                                     17

<210> 217
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 217
agaccccttc ttcaggagcg c                                                21

<210> 218
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 218
tccgatacca ataagtcagc ctgatgc                                          27

<210> 219
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 219
cgtcgagaac cagcggagaa aagaa                                            25

<210> 220
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 220
tcatccatgg tgagctggcg g                                                21
