                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       SU, Lishan
 
<120>  FUSION PROTEINS AND METHODS OF USING THE SAME FOR THE DETECTION 
       OF NEUTRALIZING ANTIBODIES

<130>  5470.890.WO

<150>  US 63/146,796
<151>  2020-02-08

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  246
<212>  PRT
<213>  SARS Coronavirus

<400>  1

Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
1               5                   10                  15      


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
            20                  25                  30          


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
        35                  40                  45              


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
    50                  55                  60                  


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
65                  70                  75                  80  


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
                85                  90                  95      


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
            100                 105                 110         


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
        115                 120                 125             


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
    130                 135                 140                 


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
145                 150                 155                 160 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
                165                 170                 175     


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
            180                 185                 190         


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
        195                 200                 205             


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
    210                 215                 220                 


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
225                 230                 235                 240 


Gly Leu Thr Gly Thr Gly 
                245     


<210>  2
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly 
                85                  90          


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Met Val Asn Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val 
1               5                   10                  15      


Ala Glu Ala 
            


<210>  6
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Val Asn Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val 
1               5                   10                  15      


Ala Glu Ala Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala 
            20                  25                  30          


Val Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys 
        35                  40                  45              


Leu Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala 
    50                  55                  60                  


Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser 
65                  70                  75                  80  


His Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys 
                85                  90                  95      


His Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Phe Thr Val Glu Lys 
        115                 120                 125             


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
    130                 135                 140                 


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
145                 150                 155                 160 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
                165                 170                 175     


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
            180                 185                 190         


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
        195                 200                 205             


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
    210                 215                 220                 


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
225                 230                 235                 240 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
                245                 250                 255     


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
            260                 265                 270         


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
        275                 280                 285             


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
    290                 295                 300                 


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
305                 310                 315                 320 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                325                 330                 335     


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
            340                 345                 350         


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
        355                 360                 365             


His His His His His His His 
    370                 375 


<210>  7
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Val Asn Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val 
1               5                   10                  15      


Ala Glu Ala Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala 
            20                  25                  30          


Val Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys 
        35                  40                  45              


Leu Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala 
    50                  55                  60                  


Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser 
65                  70                  75                  80  


His Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys 
                85                  90                  95      


His Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Phe Thr Val Glu Lys 
        115                 120                 125             


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
    130                 135                 140                 


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
145                 150                 155                 160 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
                165                 170                 175     


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
            180                 185                 190         


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
        195                 200                 205             


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
    210                 215                 220                 


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
225                 230                 235                 240 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
                245                 250                 255     


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
            260                 265                 270         


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
        275                 280                 285             


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
    290                 295                 300                 


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
305                 310                 315                 320 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                325                 330                 335     


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
            340                 345                 350         


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
        355                 360                 365             


<210>  8
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Ser Gly Gly Ser Gly Gly Ser Phe Thr Val Glu Lys Gly Ile Tyr 
            100                 105                 110         


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
        115                 120                 125             


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
    130                 135                 140                 


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
145                 150                 155                 160 


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
                165                 170                 175     


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
            180                 185                 190         


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
        195                 200                 205             


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
    210                 215                 220                 


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
225                 230                 235                 240 


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
                245                 250                 255     


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
            260                 265                 270         


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
        275                 280                 285             


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
    290                 295                 300                 


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
305                 310                 315                 320 


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
                325                 330                 335     


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
            340                 345                 


<210>  9
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Ser Gly Gly Ser Gly Gly Ser Phe Thr Val Glu Lys Gly Ile Tyr 
            100                 105                 110         


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
        115                 120                 125             


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
    130                 135                 140                 


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
145                 150                 155                 160 


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
                165                 170                 175     


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
            180                 185                 190         


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
        195                 200                 205             


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
    210                 215                 220                 


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
225                 230                 235                 240 


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
                245                 250                 255     


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
            260                 265                 270         


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
        275                 280                 285             


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
    290                 295                 300                 


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
305                 310                 315                 320 


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
                325                 330                 335     


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly His His His 
            340                 345                 350         


His His His His 
        355     


<210>  10
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala Asp 
        595     


<210>  11
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro 
1               5                   10                  15      


Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr 
            20                  25                  30          


Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys 
        35                  40                  45              


Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly 
    50                  55                  60                  


Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
65                  70                  75  


<210>  12
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Val Asn Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val 
1               5                   10                  15      


Ala Glu Ala Lys Pro Thr Glu Ala Ile Val Asp Ile Pro Glu Ile Pro 
            20                  25                  30          


Gly Phe Lys Asp Leu Glu Pro Met Glu Gln Phe Ile Ala Gln Val Asp 
        35                  40                  45              


Leu Cys Val Asp Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala Asn Val 
    50                  55                  60                  


Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr 
65                  70                  75                  80  


Phe Ala Ser Lys Ile Gln Gly Gln Val Asp Lys Ile Lys Gly Ala Gly 
                85                  90                  95      


Gly Asp Asp Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Thr 
            100                 105                 110         


Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
        115                 120                 125             


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
    130                 135                 140                 


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
145                 150                 155                 160 


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
                165                 170                 175     


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
            180                 185                 190         


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
        195                 200                 205             


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
    210                 215                 220                 


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
225                 230                 235                 240 


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
                245                 250                 255     


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
            260                 265                 270         


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
        275                 280                 285             


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
    290                 295                 300                 


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
305                 310                 315                 320 


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
                325                 330                 335     


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
            340                 345                 350         


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
        355                 360                 365             


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
    370                 375                 380                 


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
385                 390                 395                 400 


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
                405                 410                 415     


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
            420                 425                 430         


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
        435                 440                 445             


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
    450                 455                 460                 


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
465                 470                 475                 480 


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
                485                 490                 495     


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
            500                 505                 510         


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
        515                 520                 525             


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
    530                 535                 540                 


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
545                 550                 555                 560 


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
                565                 570                 575     


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
            580                 585                 590         


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
        595                 600                 605             


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
    610                 615                 620                 


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
625                 630                 635                 640 


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
                645                 650                 655     


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
            660                 665                 670         


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
        675                 680                 685             


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
    690                 695                 700                 


Tyr Ala Asp His His His His His His His 
705                 710                 


<210>  13
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Val Asn Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val 
1               5                   10                  15      


Ala Glu Ala Lys Pro Thr Glu Ala Ile Val Asp Ile Pro Glu Ile Pro 
            20                  25                  30          


Gly Phe Lys Asp Leu Glu Pro Met Glu Gln Phe Ile Ala Gln Val Asp 
        35                  40                  45              


Leu Cys Val Asp Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala Asn Val 
    50                  55                  60                  


Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr 
65                  70                  75                  80  


Phe Ala Ser Lys Ile Gln Gly Gln Val Asp Lys Ile Lys Gly Ala Gly 
                85                  90                  95      


Gly Asp Asp Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Thr 
            100                 105                 110         


Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
        115                 120                 125             


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
    130                 135                 140                 


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
145                 150                 155                 160 


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
                165                 170                 175     


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
            180                 185                 190         


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
        195                 200                 205             


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
    210                 215                 220                 


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
225                 230                 235                 240 


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
                245                 250                 255     


Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr 
            260                 265                 270         


Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His Tyr 
        275                 280                 285             


Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly Val 
    290                 295                 300                 


Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu His 
305                 310                 315                 320 


Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr Val 
                325                 330                 335     


Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile Gly 
            340                 345                 350         


Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr 
        355                 360                 365             


Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp 
    370                 375                 380                 


Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile Phe 
385                 390                 395                 400 


Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr 
                405                 410                 415     


Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln 
            420                 425                 430         


Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe 
        435                 440                 445             


Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala 
    450                 455                 460                 


His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln 
465                 470                 475                 480 


Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val 
                485                 490                 495     


Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys Ser 
            500                 505                 510         


Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile 
        515                 520                 525             


Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe 
    530                 535                 540                 


Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile 
545                 550                 555                 560 


Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu Ile 
                565                 570                 575     


Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro 
            580                 585                 590         


Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr 
        595                 600                 605             


Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala 
    610                 615                 620                 


Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Thr 
625                 630                 635                 640 


Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser Glu 
                645                 650                 655     


Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met Asn 
            660                 665                 670         


Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys 
        675                 680                 685             


Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser Pro 
    690                 695                 700                 


Tyr Ala Asp 
705         


<210>  14
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro 
1               5                   10                  15      


Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr 
            20                  25                  30          


Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys 
        35                  40                  45              


Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly 
    50                  55                  60                  


Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp Asp Thr Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Ser Gly Gly Thr Ile Glu Glu Gln Ala Lys Thr 
                85                  90                  95      


Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser 
            100                 105                 110         


Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val 
        115                 120                 125             


Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu 
    130                 135                 140                 


Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu 
145                 150                 155                 160 


Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val 
                165                 170                 175     


Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met 
            180                 185                 190         


Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln 
        195                 200                 205             


Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser 
    210                 215                 220                 


Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu 
225                 230                 235                 240 


Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys 
                245                 250                 255     


Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp 
            260                 265                 270         


Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg 
        275                 280                 285             


Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro 
    290                 295                 300                 


Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala 
305                 310                 315                 320 


Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu 
                325                 330                 335     


Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val 
            340                 345                 350         


Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp 
        355                 360                 365             


Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe 
    370                 375                 380                 


Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser 
385                 390                 395                 400 


Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr 
                405                 410                 415     


Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys 
            420                 425                 430         


Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile 
        435                 440                 445             


Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly 
    450                 455                 460                 


Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser 
465                 470                 475                 480 


Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp 
                485                 490                 495     


Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala 
            500                 505                 510         


Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp 
        515                 520                 525             


Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys 
    530                 535                 540                 


Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val 
545                 550                 555                 560 


Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser 
                565                 570                 575     


Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe 
            580                 585                 590         


Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu 
        595                 600                 605             


His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    610                 615                 620                 


Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu 
625                 630                 635                 640 


Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr 
                645                 650                 655     


Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe 
            660                 665                 670         


Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp 
        675                 680                 


<210>  15
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro 
1               5                   10                  15      


Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr 
            20                  25                  30          


Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys 
        35                  40                  45              


Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly 
    50                  55                  60                  


Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp Asp Thr Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Ser Gly Gly Thr Ile Glu Glu Gln Ala Lys Thr 
                85                  90                  95      


Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser 
            100                 105                 110         


Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val 
        115                 120                 125             


Gln Asn Met Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu 
    130                 135                 140                 


Gln Ser Thr Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu 
145                 150                 155                 160 


Thr Val Lys Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val 
                165                 170                 175     


Leu Ser Glu Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met 
            180                 185                 190         


Ser Thr Ile Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln 
        195                 200                 205             


Glu Cys Leu Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser 
    210                 215                 220                 


Leu Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu 
225                 230                 235                 240 


Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys 
                245                 250                 255     


Asn Glu Met Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp 
            260                 265                 270         


Arg Gly Asp Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg 
        275                 280                 285             


Gly Gln Leu Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro 
    290                 295                 300                 


Leu Tyr Glu His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala 
305                 310                 315                 320 


Tyr Pro Ser Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu 
                325                 330                 335     


Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val 
            340                 345                 350         


Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp 
        355                 360                 365             


Gln Ala Trp Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe 
    370                 375                 380                 


Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser 
385                 390                 395                 400 


Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr 
                405                 410                 415     


Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys 
            420                 425                 430         


Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile 
        435                 440                 445             


Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly 
    450                 455                 460                 


Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser 
465                 470                 475                 480 


Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp 
                485                 490                 495     


Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala 
            500                 505                 510         


Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp 
        515                 520                 525             


Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys 
    530                 535                 540                 


Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val 
545                 550                 555                 560 


Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser 
                565                 570                 575     


Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe 
            580                 585                 590         


Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu 
        595                 600                 605             


His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe 
    610                 615                 620                 


Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu 
625                 630                 635                 640 


Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr 
                645                 650                 655     


Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe 
            660                 665                 670         


Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp His His His His 
        675                 680                 685             


His His His 
    690     


