                         SEQUENCE LISTING

<110>  NGM BIOPHARMACEUTICALS, INC.
 
<120>  HTRA1-BINDING AGENTS AND METHODS OF USE THEREOF

<130>  13370-125-228

<140>  To be assigned
<141>  on even date herewith

<150>  63/146,992
<151>  2021-02-08

<160>  133   

<170>  PatentIn version 3.5

<210>  1
<211>  480
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human HTRA1 amino acid sequence with predicted signal sequence  

<400>  1

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro 
            20                  25                  30          


Leu Ala Ala Gly Cys Pro Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro 
        35                  40                  45              


Gln Pro Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys 
    50                  55                  60                  


Cys Glu Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu 
65                  70                  75                  80  


Gly Pro Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro 
                85                  90                  95      


Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys 
            100                 105                 110         


Ala Ser Ser Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn 
        115                 120                 125             


Leu Cys Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg 
    130                 135                 140                 


Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu 
145                 150                 155                 160 


Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val 
                165                 170                 175     


Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu 
            180                 185                 190         


Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile 
        195                 200                 205             


Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn 
    210                 215                 220                 


Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala 
225                 230                 235                 240 


Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile 
                245                 250                 255     


Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu 
            260                 265                 270         


Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu 
        275                 280                 285             


Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly 
    290                 295                 300                 


Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp 
305                 310                 315                 320 


Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp 
                325                 330                 335     


Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser 
            340                 345                 350         


Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His 
        355                 360                 365             


Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly 
    370                 375                 380                 


Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp 
385                 390                 395                 400 


Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu 
                405                 410                 415     


Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp 
            420                 425                 430         


Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val 
        435                 440                 445             


Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg 
    450                 455                 460                 


Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
465                 470                 475                 480 


<210>  2
<211>  458
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human HTRA1 amino acid sequence without predicted signal sequence  

<400>  2

Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro Leu Ala Ala Gly Cys Pro 
1               5                   10                  15      


Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro Gln Pro Glu His Cys Glu 
            20                  25                  30          


Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys Cys Glu Val Cys Gly Ala 
        35                  40                  45              


Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu Gly Pro Cys Gly Glu Gly 
    50                  55                  60                  


Leu Gln Cys Val Val Pro Phe Gly Val Pro Ala Ser Ala Thr Val Arg 
65                  70                  75                  80  


Arg Arg Ala Gln Ala Gly Leu Cys Val Cys Ala Ser Ser Glu Pro Val 
                85                  90                  95      


Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys Gln Leu Arg Ala 
            100                 105                 110         


Ala Ser Arg Arg Ser Glu Arg Leu His Arg Pro Pro Val Ile Val Leu 
        115                 120                 125             


Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser Leu Arg 
    130                 135                 140                 


His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Ile Ala Pro Ala 
145                 150                 155                 160 


Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe Ser Lys Arg Glu 
                165                 170                 175     


Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser Glu Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Thr Asn Lys His Arg Val Lys Val 
        195                 200                 205             


Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val Asp 
    210                 215                 220                 


Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His Gln Gly Lys Leu 
225                 230                 235                 240 


Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu Phe 
                245                 250                 255     


Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr Val Thr Thr 
            260                 265                 270         


Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu Arg 
        275                 280                 285             


Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly 
    290                 295                 300                 


Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile 
305                 310                 315                 320 


Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp 
                325                 330                 335     


Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg Gln Ala Lys Gly 
            340                 345                 350         


Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met Met Ser Leu 
        355                 360                 365             


Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His Arg Asp Phe Pro 
    370                 375                 380                 


Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro Asp Thr Pro 
385                 390                 395                 400 


Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile Ile Ser Ile Asn 
                405                 410                 415     


Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp Val Ile Lys Arg 
            420                 425                 430         


Glu Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn Glu Asp Ile Met 
        435                 440                 445             


Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
    450                 455             


<210>  3
<211>  380
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human HTRA1 amino acid sequence without N-terminal domain, 
aa 101-480

<400>  3

Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys Ala Ser Ser Glu 
1               5                   10                  15      


Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys Gln Leu 
            20                  25                  30          


Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg Pro Pro Val Ile 
        35                  40                  45              


Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser 
    50                  55                  60                  


Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Ile Ala 
65                  70                  75                  80  


Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe Ser Lys 
                85                  90                  95      


Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser Glu Asp 
            100                 105                 110         


Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn Lys His Arg Val 
        115                 120                 125             


Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile Lys Asp 
    130                 135                 140                 


Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His Gln Gly 
145                 150                 155                 160 


Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro Gly 
                165                 170                 175     


Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr Val 
            180                 185                 190         


Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu Gly 
        195                 200                 205             


Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn 
    210                 215                 220                 


Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile 
225                 230                 235                 240 


Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro 
                245                 250                 255     


Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg Gln Ala 
            260                 265                 270         


Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met Met 
        275                 280                 285             


Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His Arg Asp 
    290                 295                 300                 


Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro Asp 
305                 310                 315                 320 


Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile Ile Ser 
                325                 330                 335     


Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp Val Ile 
            340                 345                 350         


Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn Glu Asp 
        355                 360                 365             


Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
    370                 375                 380 


<210>  4
<211>  161
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human HTRA1 serine protease domain  

<400>  4

Gly Ser Gly Phe Ile Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala 
1               5                   10                  15      


His Val Val Thr Asn Lys His Arg Val Lys Val Glu Leu Lys Asn Gly 
            20                  25                  30          


Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile 
        35                  40                  45              


Ala Leu Ile Lys Ile Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu 
    50                  55                  60                  


Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly 
65                  70                  75                  80  


Ser Pro Phe Ser Leu Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr 
                85                  90                  95      


Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp 
            100                 105                 110         


Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro 
        115                 120                 125             


Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val 
    130                 135                 140                 


Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe 
145                 150                 155                 160 


Leu 
    


<210>  5
<211>  523
<212>  PRT
<213>  Rabbit

<220>
<223>  Rabbit HTRA1 amino acid sequence with predicted signal sequence  

<400>  5

Met Gly Trp Ala Ala Arg Pro Arg Ala Leu Ala Pro Ala Ala Pro Lys 
1               5                   10                  15      


Ala Leu Arg Ser Ser Pro Arg Arg Cys Cys Pro Ala Arg Ala Gln Leu 
            20                  25                  30          


Ala Ala Val Gly Ala Ala Met Gln Ser Ser Arg Ala Ala Arg Leu Leu 
        35                  40                  45              


Pro Leu Leu Leu Leu Leu Leu Ala Ala Pro Ala Trp Ala Gln Pro Pro 
    50                  55                  60                  


Arg Ala Gly Arg Ser Ala Pro Ala Ala Thr Ser Pro Val Ala Gly Cys 
65                  70                  75                  80  


Pro Glu Arg Cys Glu Pro Ala Arg Cys Ala Pro Pro Pro Thr Asn Cys 
                85                  90                  95      


Glu Gly Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Glu Val Cys Gly 
            100                 105                 110         


Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu Gly Pro Cys Gly Glu 
        115                 120                 125             


Gly Leu Gln Cys Val Val Ser Phe Gly Val Pro Ala Ser Ala Thr Val 
    130                 135                 140                 


Arg Arg Arg Ser Gln Ala Gly Val Cys Val Cys Ala Ser Asn Glu Pro 
145                 150                 155                 160 


Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys Gln Leu Arg 
                165                 170                 175     


Ala Ala Ser Arg Arg Ser Glu Arg Leu Gln Gln Pro Pro Val Ile Val 
            180                 185                 190         


Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser Leu 
        195                 200                 205             


Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Ile Ala Pro 
    210                 215                 220                 


Ala Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe Ser Lys Arg 
225                 230                 235                 240 


Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser Glu Asp Gly 
                245                 250                 255     


Leu Ile Val Thr Asn Ala His Val Val Thr Asn Lys His Arg Val Lys 
            260                 265                 270         


Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val 
        275                 280                 285             


Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His Gln Gly Lys 
    290                 295                 300                 


Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu 
305                 310                 315                 320 


Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr Val Thr 
                325                 330                 335     


Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu 
            340                 345                 350         


Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr 
        355                 360                 365             


Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly 
    370                 375                 380                 


Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser 
385                 390                 395                 400 


Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg Gln Ala Lys 
                405                 410                 415     


Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met Met Ser 
            420                 425                 430         


Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His Arg Asp Phe 
        435                 440                 445             


Pro Asp Val Leu Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro Asp Thr 
    450                 455                 460                 


Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile Ile Ser Ile 
465                 470                 475                 480 


Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp Val Ile Lys 
                485                 490                 495     


Lys Asp Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn Glu Asp Ile 
            500                 505                 510         


Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
        515                 520             


<210>  6
<211>  462
<212>  PRT
<213>  Rabbit

<220>
<223>  Rabbit HTRA1 amino acid sequence without predicted signal sequence

<400>  6

Gln Pro Pro Arg Ala Gly Arg Ser Ala Pro Ala Ala Thr Ser Pro Val 
1               5                   10                  15      


Ala Gly Cys Pro Glu Arg Cys Glu Pro Ala Arg Cys Ala Pro Pro Pro 
            20                  25                  30          


Thr Asn Cys Glu Gly Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Glu 
        35                  40                  45              


Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu Gly Pro 
    50                  55                  60                  


Cys Gly Glu Gly Leu Gln Cys Val Val Ser Phe Gly Val Pro Ala Ser 
65                  70                  75                  80  


Ala Thr Val Arg Arg Arg Ser Gln Ala Gly Val Cys Val Cys Ala Ser 
                85                  90                  95      


Asn Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys 
            100                 105                 110         


Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu Gln Gln Pro Pro 
        115                 120                 125             


Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro 
    130                 135                 140                 


Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys 
145                 150                 155                 160 


Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe 
                165                 170                 175     


Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser 
            180                 185                 190         


Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn Lys His 
        195                 200                 205             


Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile 
    210                 215                 220                 


Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His 
225                 230                 235                 240 


Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg 
                245                 250                 255     


Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn 
            260                 265                 270         


Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu 
        275                 280                 285             


Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile 
    290                 295                 300                 


Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu 
305                 310                 315                 320 


Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala 
                325                 330                 335     


Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg 
            340                 345                 350         


Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg 
        355                 360                 365             


Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His 
    370                 375                 380                 


Arg Asp Phe Pro Asp Val Leu Ser Gly Ala Tyr Ile Ile Glu Val Ile 
385                 390                 395                 400 


Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile 
                405                 410                 415     


Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp 
            420                 425                 430         


Val Ile Lys Lys Asp Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn 
        435                 440                 445             


Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
    450                 455                 460         


<210>  7
<211>  462
<212>  PRT
<213>  Cyno

<220>
<223>  Cyno HTRA1 amino acid sequence with predicted signal sequence

<400>  7

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Pro 
            20                  25                  30          


Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys Cys Glu 
        35                  40                  45              


Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu Gly Pro 
    50                  55                  60                  


Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro Ala Ser 
65                  70                  75                  80  


Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys Ala Ser 
                85                  90                  95      


Asn Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn Leu Cys 
            100                 105                 110         


Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg Pro Pro 
        115                 120                 125             


Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu Asp Pro 
    130                 135                 140                 


Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val Glu Lys 
145                 150                 155                 160 


Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu Pro Phe 
                165                 170                 175     


Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile Val Ser 
            180                 185                 190         


Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn Lys His 
        195                 200                 205             


Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala Lys Ile 
    210                 215                 220                 


Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile Asp His 
225                 230                 235                 240 


Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg 
                245                 250                 255     


Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn 
            260                 265                 270         


Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu 
        275                 280                 285             


Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile 
    290                 295                 300                 


Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu 
305                 310                 315                 320 


Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala 
                325                 330                 335     


Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg 
            340                 345                 350         


Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg 
        355                 360                 365             


Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His 
    370                 375                 380                 


Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu Val Ile 
385                 390                 395                 400 


Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile 
                405                 410                 415     


Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp 
            420                 425                 430         


Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn 
        435                 440                 445             


Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
    450                 455                 460         


<210>  8
<211>  439
<212>  PRT
<213>  Cyno

<220>
<223>  Cyno HTRA1 amino acid sequence without predicted signal sequence

<400>  8

Gln Leu Ser Arg Ala Gly Arg Ser Pro Glu His Cys Glu Gly Gly Arg 
1               5                   10                  15      


Ala Arg Asp Ala Cys Gly Cys Cys Glu Val Cys Gly Ala Pro Glu Gly 
            20                  25                  30          


Ala Ala Cys Gly Leu Gln Glu Gly Pro Cys Gly Glu Gly Leu Gln Cys 
        35                  40                  45              


Val Val Pro Phe Gly Val Pro Ala Ser Ala Thr Val Arg Arg Arg Ala 
    50                  55                  60                  


Gln Ala Gly Leu Cys Val Cys Ala Ser Asn Glu Pro Val Cys Gly Ser 
65                  70                  75                  80  


Asp Ala Asn Thr Tyr Ala Asn Leu Cys Gln Leu Arg Ala Ala Ser Arg 
                85                  90                  95      


Arg Ser Glu Arg Leu His Arg Pro Pro Val Ile Val Leu Gln Arg Gly 
            100                 105                 110         


Ala Cys Gly Gln Gly Gln Glu Asp Pro Asn Ser Leu Arg His Lys Tyr 
        115                 120                 125             


Asn Phe Ile Ala Asp Val Val Glu Lys Ile Ala Pro Ala Val Val His 
    130                 135                 140                 


Ile Glu Leu Phe Arg Lys Leu Pro Phe Ser Lys Arg Glu Val Pro Val 
145                 150                 155                 160 


Ala Ser Gly Ser Gly Phe Ile Val Ser Glu Asp Gly Leu Ile Val Thr 
                165                 170                 175     


Asn Ala His Val Val Thr Asn Lys His Arg Val Lys Val Glu Leu Lys 
            180                 185                 190         


Asn Gly Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val Asp Glu Lys Ala 
        195                 200                 205             


Asp Ile Ala Leu Ile Lys Ile Asp His Gln Gly Lys Leu Pro Val Leu 
    210                 215                 220                 


Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu Phe Val Val Ala 
225                 230                 235                 240 


Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr Val Thr Thr Gly Ile Val 
                245                 250                 255     


Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu Arg Asn Ser Asp 
            260                 265                 270         


Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn Ser Gly 
        275                 280                 285             


Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn Thr Leu 
    290                 295                 300                 


Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Lys Ile Lys 
305                 310                 315                 320 


Lys Phe Leu Thr Glu Ser His Asp Arg Gln Ala Lys Gly Lys Ala Ile 
                325                 330                 335     


Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met Met Ser Leu Thr Ser Ser 
            340                 345                 350         


Lys Ala Lys Glu Leu Lys Asp Arg His Arg Asp Phe Pro Asp Val Ile 
        355                 360                 365             


Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro Asp Thr Pro Ala Glu Ala 
    370                 375                 380                 


Gly Gly Leu Lys Glu Asn Asp Val Ile Ile Ser Ile Asn Gly Gln Ser 
385                 390                 395                 400 


Val Val Ser Ala Asn Asp Val Ser Asp Val Ile Lys Arg Glu Ser Thr 
                405                 410                 415     


Leu Asn Met Val Val Arg Arg Gly Asn Glu Asp Ile Met Ile Thr Val 
            420                 425                 430         


Ile Pro Glu Glu Ile Asp Pro 
        435                 


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibodies 24F7 & 
Hz24F7.v2 - Exemplary & AbM

<400>  9

Gly Tyr Thr Phe Thr Asp Tyr Glu Met His 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 24F7 & Hz24F7.v2
 - Exemplary & Kabat

<400>  10

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 - Exemplary, Chothia, AbM 
& Kabat

<400>  11

Glu Gly Tyr Ser Tyr Asp Gly Gly Gly Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibodies 24F7 & Hz24F7.v2
 - Exemplary, Chothia, AbM & Kabat

<400>  12

Ser Val Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR2 of Antibodies 24F7, Hz24F7.v2 
& 65G8 - Exemplary, Chothia, AbM & Kabat

<400>  13

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 Antibodies 24F7 & Hz24F7.v2 - 
Exemplary, Chothia, AbM & Kabat

<400>  14

Gln Gln Trp Ser Ser Tyr Pro Thr 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibodies 24F7 & Hz24F7.v2
 - Chothia

<400>  15

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 24F7 & Hz24F7.v2
 - Chothia

<400>  16

Asp Pro Glu Thr Gly Gly 
1               5       


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 24F7 & Hz24F7.v2
 - AbM

<400>  17

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala 
1               5                   10  


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibodies 24F7 & Hz24F7.v2
 - Kabat

<400>  18

Asp Tyr Glu Met His 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibodies 24F7 & Hz24F7.v2
 - Contact

<400>  19

Thr Asp Tyr Glu Met His 
1               5       


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 24F7 & Hz24F7.v2
  - Contact

<400>  20

Trp Ile Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala 
1               5                   10              


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 - Contact

<400>  21

Thr Arg Glu Gly Tyr Ser Tyr Asp Gly Gly Gly Tyr Tyr Phe Asp 
1               5                   10                  15  


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibodies 24F7, 
Hz24F7.v2 & 65G8 - Contact

<400>  22

Ser Tyr Met Tyr Trp Tyr 
1               5       


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR2 of Antibodies 24F7, 
Hz24F7.v2 & 65G8 - Contact

<400>  23

Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
1               5                   10  


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibodies 24F7 & 
Hz24F7.v2 - Contact

<400>  24

Gln Gln Trp Ser Ser Tyr Pro 
1               5           


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody Hz24F7.v2
 - Exemplary, Chothia, AbM & Kabat

<400>  25

Glu Gly Tyr Ser Tyr Glu Gly Gly Gly Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody Hz24F7.v2
 - Contact

<400>  26

Thr Arg Glu Gly Tyr Ser Tyr Glu Gly Gly Gly Tyr Tyr Phe Asp 
1               5                   10                  15  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 9F8 - 
Exemplary & AbM

<400>  27

Gly Tyr Ala Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibody 9F8 
- Exemplary & Kabat

<400>  28

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody 9F8 - 
Exemplary, Chothia, AbM & Kabat

<400>  29

Asp Tyr Gly Ala Phe Asp Val 
1               5           


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibody 9F8 - 
Exemplary, Chothia, AbM & Kabat

<400>  30

Arg Ser Ser Thr Gly Ala Val Thr Thr Arg Asn Phe Ala Ser 
1               5                   10                  


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR2 of Antibody 9F8 - 
Exemplary, Chothia, AbM & Kabat

<400>  31

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibody 9F8 - 
Exemplary, Chothia, AbM & Kabat

<400>  32

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 9F8
 - Chothia

<400>  33

Gly Tyr Ala Phe Thr Thr Tyr 
1               5           


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 9F8, 
65G8 & 55B12 - Chothia

<400>  34

Asp Pro Ser Asp Ser Glu 
1               5       


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 
9F8 & 55B12 - AbM

<400>  35

Asn Ile Asp Pro Ser Asp Ser Glu Thr His 
1               5                   10  


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 9F8
 - Kabat

<400>  36

Thr Tyr Trp Met His 
1               5   


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 9F8 
- Contact

<400>  37

Thr Thr Tyr Trp Met His 
1               5       


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibodies 
9F8 & 55B12  - Contact

<400>  38

Trp Ile Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His 
1               5                   10              


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody 9F8
 - Contact

<400>  39

Ala Arg Asp Tyr Gly Ala Phe Asp 
1               5               


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibody 9F8 
- Contact

<400>  40

Val Thr Thr Arg Asn Phe Ala Ser Trp Val 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR2 of Antibody 9F8
 - Contact

<400>  41

Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala 
1               5                   10  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibody 9F8 
- Contact

<400>  42

Ala Leu Trp Tyr Ser Asn Leu Trp 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 55B12
 - Exemplary & AbM

<400>  43

Gly Tyr Thr Phe Thr Asn Tyr Trp Met His 
1               5                   10  


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibody 55B12 
- Exemplary & Kabat

<400>  44

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody 55B12 - 
Exemplary, Chothia, AbM & Kabat

<400>  45

Glu Asp Ser Ser Gly Tyr Gly Ala Tyr 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibody 55B12 - 
Exemplary, Chothia, AbM & Kabat

<400>  46

Ser Ala Ser Ser Ser Val Asn Tyr Met His 
1               5                   10  


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR2 of Antibody 55B12 - 
Exemplary, Chothia, AbM & Kabat

<400>  47

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibody 55B12 - 
Exemplary, Chothia, AbM & Kabat

<400>  48

Gln Gln Trp Ser Ser His Pro Leu Thr 
1               5                   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 55B12
 - Chothia

<400>  49

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 55B12-Kabat

<400>  50

Asn Tyr Trp Met His 
1               5   


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 55B12-Contact

<400>  51

Thr Asn Tyr Trp Met His 
1               5       


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody 55B12-Contact

<400>  52

Ala Arg Glu Asp Ser Ser Gly Tyr Gly Ala 
1               5                   10  


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibody 55B12-Contact

<400>  53

Asn Tyr Met His Trp Tyr 
1               5       


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR2 of Antibody 55B12 -Contact

<400>  54

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
1               5                   10  


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibody 55B12 -Contact

<400>  55

Gln Gln Trp Ser Ser His Pro Leu 
1               5               


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 65G8 - 
Exemplary & AbM

<400>  56

Gly Tyr Ser Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibody 65G8 - 
Exemplary & Kabat

<400>  57

Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody 65G8 - 
Exemplary, Chothia, AbM & Kabat

<400>  58

Asp Tyr Phe Asp Tyr 
1               5   


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR1 of Antibody 65G8 - 
Exemplary, Chothia, AbM & Kabat

<400>  59

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibody 65G8 - 
Exemplary, Chothia, AbM & Kabat

<400>  60

Gln Gln Trp Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 65G8 -Chothia

<400>  61

Gly Tyr Ser Phe Thr Ser Tyr 
1               5           


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibody 65G8 - AbM

<400>  62

Met Ile Asp Pro Ser Asp Ser Glu Thr Arg 
1               5                   10  


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 65G8 -Kabat

<400>  63

Ser Tyr Trp Met His 
1               5   


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR1 of Antibody 65G8 -Contact

<400>  64

Thr Ser Tyr Trp Met His 
1               5       


<210>  65
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR2 of Antibody 65G8 -Contact

<400>  65

Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg 
1               5                   10              


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain variable region CDR3 of Antibody 65G8 -Contact

<400>  66

Thr Arg Asp Tyr Phe Asp 
1               5       


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain variable region CDR3 of Antibody 65G8 -Contact

<400>  67

Gln Gln Trp Ser Ser Tyr Pro Tyr 
1               5               


<210>  68
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24F7 Heavy chain variable region amino acid sequence  

<400>  68

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Tyr Ser Tyr Asp Gly Gly Gly Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  69
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24F7 Light chain variable region amino acid sequence  

<400>  69

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  70
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7 Heavy chain variable region amino acid sequence  

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Tyr Asp Gly Gly Gly Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  71
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 variant Heavy chain variable region amino acid sequence 

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Tyr Ser Tyr Glu Gly Gly Gly Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  72
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 Light chain variable region amino acid sequence  

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  73
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F8 Heavy chain variable region amino acid sequence  

<400>  73

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Ala Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  74
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F8 Light chain variable region amino acid sequence  

<400>  74

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Ser Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Arg 
            20                  25                  30          


Asn Phe Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  55B12 Heavy chain variable region amino acid sequence  

<400>  75

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Ala Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Ser Gly Tyr Gly Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  76
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  55B12 Light chain variable region amino acid sequence  

<400>  76

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  77
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  65G8 Heavy chain variable region amino acid sequence  

<400>  77

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  78
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  65G8 Light chain variable region amino acid sequence  

<400>  78

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  79
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region 

<400>  79

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  80
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region E233A/L235A  

<400>  80

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  81
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region L234A/L235A  

<400>  81

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  82
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region L234A/L235A/P329G  

<400>  82

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  83
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region N297G  

<400>  83

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  84
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region N297G/H310A  

<400>  84

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  85
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Kappa light chain constant region  

<400>  85

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  86
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Lambda light chain constant region  

<400>  86

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  87
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 Heavy chain amino acid sequence with signal sequence 

<400>  87

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Arg Leu Glu Trp Met Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr 
65                  70                  75                  80  


Ala Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Thr Arg Glu Gly Tyr Ser Tyr Glu Gly Gly 
        115                 120                 125             


Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  88
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 Heavy chain amino acid sequence without signal sequence 

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Tyr Ser Tyr Glu Gly Gly Gly Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  89
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 Light chain amino acid sequence with signal sequence

<400>  89

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  90
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 Light chain amino acid sequence without signal sequence

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate peptide  

<220>
<221>  MOD_RES 
<222>  (9)..(9)
<223>  Xaa is Lys with a dnp molecule attached

<400>  91

Ile Arg Arg Val Ser Tyr Ser Phe Xaa Lys 
1               5                   10  


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTRA1 peptide  

<400>  92

Arg Lys Leu Pro Phe Ser Lys Arg Glu Val Pro Val 
1               5                   10          


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hexa-histidine tag  

<400>  93

His His His His His His 
1               5       


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S91Y Light Chain CDR3 - 
Exemplary, Chothia, AbM & Kabat

<400>  94

Gln Gln Trp Tyr Ser Tyr Pro Thr 
1               5               


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S91Y mutation Light Chain CDR3 - Contact

<400>  95

Gln Gln Trp Tyr Ser Tyr Pro 
1               5               


<210>  96
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S91Y Light chain variable region amino acid sequence  

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Tyr Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  97
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S91Y Light chain amino acid sequence with signal sequence

<400>  97

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Tyr Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  98
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S91Y Light chain amino acid sequence without 
signal sequence

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Tyr Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S92T Light Chain CDR3 - Exemplary, 
Chothia, AbM & Kabat 

<400>  99

Gln Gln Trp Ser Thr Tyr Pro Thr 
1               5               


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S92T Light Chain CDR3 - Contact 

<400>  100

Gln Gln Trp Ser Thr Tyr Pro 
1               5           


<210>  101
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S92T Light chain variable region amino acid sequence  

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Tyr Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  102
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S92T Light chain amino acid sequence with signal 
sequence 

<400>  102

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Thr Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  103
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz24F7.v2 S92T Light chain amino acid sequence without signal 
sequence 

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91D Light Chain CDR3 - Exemplary, Chothia, AbM
and Kabat

<400>  104

Gln Gln Trp Asp Ser Tyr Pro Thr 
1               5               


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91D Light Chain CDR3 - Contact

<400>  105

Gln Gln Trp Asp Ser Tyr Pro 
1               5           


<210>  106
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91D Light chain variable region amino acid sequence

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91T Light Chain CDR3 - Exemplary, Chothia, 
AbM and Kabat

<400>  107

Gln Gln Trp Thr Ser Tyr Pro Thr 
1               5               


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91T Light Chain CDR3 - Contact

<400>  108

Gln Gln Trp Thr Ser Tyr Pro 
1               5           


<210>  109
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91T Light chain variable region amino acid sequence

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91A Light Chain CDR3 - Exemplary, Chothia, 
AbM and Kabat

<400>  110

Gln Gln Trp Ala Ser Tyr Pro Thr 
1               5               


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91A Light Chain CDR3 - Contact

<400>  111

Gln Gln Trp Ala Ser Tyr Pro 
1               5           


<210>  112
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91A Light chain variable region amino acid sequence

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ala Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91L Light Chain CDR3 - Exemplary, Chothia, 
AbM and Kabat

<400>  113

Gln Gln Trp Leu Ser Tyr Pro Thr 
1               5               


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91L Light Chain CDR3 - Contact

<400>  114

Gln Gln Trp Leu Ser Tyr Pro 
1               5           


<210>  115
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91L Light chain variable region amino acid sequence

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92Y Light Chain CDR3 - Exemplary, Chothia, 
AbM and Kabat

<400>  116

Gln Gln Trp Ser Tyr Tyr Pro Thr 
1               5               


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92Y Light Chain CDR3 - Contact

<400>  117

Gln Gln Trp Ser Tyr Tyr Pro 
1               5           


<210>  118
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92Y Light chain variable region amino acid sequence

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Tyr Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92D Light Chain CDR3 - Exemplary, Chothia, 
AbM and Kabat

<400>  119

Gln Gln Trp Ser Asp Tyr Pro Thr 
1               5               


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92D Light Chain CDR3 - Contact

<400>  120

Gln Gln Trp Ser Asp Tyr Pro 
1               5           


<210>  121
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92D Light chain variable region amino acid sequence

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  122
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91D Light chain amino acid sequence with signal sequence 

<400>  122

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asp Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  123
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91D Light chain amino acid sequence without 
signal sequence

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  124
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91T Light chain amino acid sequence with signal sequence 

<400>  124

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Thr Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  125
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91T Light chain amino acid sequence without signal sequence

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  126
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91A Light chain amino acid sequence with signal sequence 

<400>  126

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ala Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  127
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91A Light chain amino acid sequence without 
signal sequence

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ala Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  128
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91L Light chain amino acid sequence with 
signal sequence 

<400>  128

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  129
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S91L Light chain amino acid sequence without 
signal sequence

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  130
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92Y Light chain amino acid sequence with 
signal sequence 

<400>  130

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Tyr Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  131
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92Y Light chain amino acid sequence without 
signal sequence

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Tyr Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  132
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92D Light chain amino acid sequence with 
signal sequence 

<400>  132

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Asp Tyr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  133
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hz24F7.v2 S92D Light chain amino acid sequence without 
signal sequence

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         