                         SEQUENCE LISTING

<110>  NEW YOUK UNIVERSITY
 
<120>  SEAMLESS INTEGRATION OF ENGINEERED ZINC FINGERS INTO ENDOGENOUS 
       TRANSCRIPTION FACTORS TO COMMANDEER THEIR NATURAL FUNCTIONS

<130>  058636.00480

<150>  63/145,929
<151>  2021-02-04

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  1

Asn Ser Thr Ala Leu Gln Ala Arg Asn Asp Ser Arg 
1               5                   10          


<210>  2
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  2

Asn Asn Asn Ala Cys Ala Ala Ala Gly 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragmen

<400>  3

Asn Asn Asn Ala Cys Ala Ala Ala Gly 
1               5                   


<210>  4
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  4

Arg Ser Asp Asn Arg Ala 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  5

Gln Leu Ala Thr Ser Asn 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  6

Asp Gln Ser Asn Thr Arg 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  7

Phe Gln Ser Gly Ile Gln 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  8

His Lys Arg Asn Thr Asp 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  9

Asp Gln Ser Ala Leu Gly 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  10

Thr Lys Gln Asn Thr His 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  11

Gln Leu Ala Thr Ser Tyr 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  12

Arg Asn Gly Asn Thr Arg 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  13

Tyr Gln Pro Asn Ile Asn 
1               5       


<210>  14
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  14
agtcgcccag ctgggggcgg g                                                 21


<210>  15
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  15

Ala Cys Asp Glu Phe Gly His Ile Lys Leu Met Asn Pro Gln Arg Ser 
1               5                   10                  15      


Thr Val Trp Tyr Ala Cys Asp Glu Phe Gly His Ile Lys Leu Met Asn 
            20                  25                  30          


Pro Gln Arg Ser Thr Val Trp Tyr 
        35                  40  


<210>  16
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  16

Ala Glu Lys Asn Gln Arg Thr Val 
1               5               


<210>  17
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  17

Ala Asp His Asn Ser Thr Val 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  18

Ala Asp His Lys Asn Gln Arg Ser 
1               5               


<210>  19
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  19

Asn Lys Arg Ser 
1               


<210>  20
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  20

Ala Asp His Asn Gln Arg Thr 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  21

Ala Glu Lys Asn Gln Arg Thr Val 
1               5               


<210>  22
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  22

Asp His Asn Ser Thr Val 
1               5       


<210>  23
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  23

Arg Ser Asp Asn Leu Arg Ala 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  24

Arg Ser Asp Asn Leu Arg Ala 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  25

Gln Leu Ala Thr Leu Ser Asn 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  26

Asp Gln Ser Asn Leu Thr Arg 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  27

Asp Gln Ser Asn Leu Thr Arg 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  28

Phe Gln Ser Gly Leu Ile Gln 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  29

His Lys Arg Asn Leu Thr Asp 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  30

Asp Gln Ser Ala Leu Leu Gly 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  31

Thr Lys Gln Asn Leu Thr His 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  32

Gln Leu Ala Thr Leu Ser Tyr 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  33

Tyr Gln Pro Asn Leu Ile Asn 
1               5           


<210>  34
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  34

Ala Arg Asn Asp Ser Arg 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  35

Ala Arg Asn Asp Ser Arg 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  36

Asn Ser Thr Ala Leu Gln 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  37

Arg Thr Asn Ser Gln Asp 
1               5       


<210>  38
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  38

Arg Asn Thr Asn Ser Gln Asp 
1               5           


<210>  39
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  39

Gln Ile Gly Ser Gln Phe 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  40

Asp Thr Asn Arg Lys His 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  41

Gly Leu Ala Ser Gln Asp 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  42

His Thr Asn Gln Lys Thr 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  43

Tyr Ser Thr Ala Leu Gln 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  44

Arg Thr Asn Gly Asn Arg 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  45

Asn Ile Asn Pro Gln Tyr 
1               5       


<210>  46
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  46
gtctctatca ctgataggga ga                                                22


<210>  47
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  47
gtctctatca ctgataggga g                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  48
tctctatcac tgatagggag a                                                 21


<210>  49
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  49
tctccctatc agtgatagag ac                                                22


<210>  50
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  50
tctccctatc agtgatagag a                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  51
ctccctatca gtgatagaga c                                                 21


<210>  52
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  52

Gln Lys Val His Leu Gln Ser Arg Lys Trp Thr Leu Ser Val Arg Lys 
1               5                   10                  15      


Gly Thr Leu Gln Asp Gln Tyr Ser Ser Leu Tyr Lys Arg Lys Gly Asp 
            20                  25                  30          


Leu Asn Lys Asp Pro Ser Ser Leu Arg Arg 
        35                  40          


<210>  53
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  53

Arg Lys Tyr Asn Leu Leu Arg Arg Arg Tyr Ser Leu Ser Ala Gln Lys 
1               5                   10                  15      


Ala His Leu Leu Ser Asp Pro Ser Asn Leu Arg Arg Gln Lys Arg Leu 
            20                  25                  30          


Leu Gln Asn Trp Lys Val Asp Leu Arg Lys 
        35                  40          


<210>  54
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  54

Arg Lys Phe Asn Leu Leu Arg Gln Ser Asn Thr Leu Arg Thr Leu Lys 
1               5                   10                  15      


His His Leu Leu Asn Thr Ser Ser Gly Leu Cys His Glu Lys Arg Thr 
            20                  25                  30          


Leu Leu Asn Trp Lys Val Asp Leu Arg Lys 
        35                  40          


<210>  55
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  55

Gln Lys Thr His Leu Leu Thr Arg Arg Asp Tyr Leu Thr Lys Arg Lys 
1               5                   10                  15      


Phe Thr Leu Leu Arg Gln Ser Asn Asp Leu Arg Lys Leu Lys Gln Thr 
            20                  25                  30          


Leu Gln Asp Arg Arg Asp Arg Leu Arg Arg 
        35                  40          


<210>  56
<211>  341
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  56

Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn 
1               5                   10                  15      


Phe Thr Gln Gly Glu Trp Gln Arg Leu Asn Pro Glu Gln Arg Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly 
        35                  40                  45              


Gln Gly Glu Thr Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Gln Gly 
    50                  55                  60                  


Lys Glu Pro Trp Leu Glu Glu Glu Glu Val Leu Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Glu Lys Asn Gly Asp Ile Gly Gly Gln Ile Trp Lys Pro Lys Asp Val 
                85                  90                  95      


Lys Glu Ser Leu Ala Arg Glu Val Pro Ser Ile Asn Lys Glu Thr Leu 
            100                 105                 110         


Thr Thr Gln Lys Gly Val Glu Cys Asp Gly Ser Lys Lys Ile Leu Pro 
        115                 120                 125             


Leu Gly Ile Asp Asp Val Ser Ser Leu Gln His Tyr Val Gln Asn Asn 
    130                 135                 140                 


Ser His Asp Asp Asn Gly Tyr Arg Lys Leu Val Gly Asn Asn Pro Ser 
145                 150                 155                 160 


Lys Phe Val Gly Gln Gln Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
                165                 170                 175     


Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile His Thr Gly Glu 
            180                 185                 190         


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser Asn 
        195                 200                 205             


Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro 
    210                 215                 220                 


Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Leu Lys 
225                 230                 235                 240 


His His Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe 
                245                 250                 255     


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Ser Gly Leu Cys 
            260                 265                 270         


His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro 
        275                 280                 285             


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu Lys Arg Thr Leu 
    290                 295                 300                 


Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu Arg Lys His Thr 
                325                 330                 335     


Lys Ile His Ser Arg 
            340     


<210>  57
<211>  373
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  57

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val Phe Ala Cys Asp Ile Cys Gly Arg Lys 
        195                 200                 205             


Phe Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile His Thr Gly 
    210                 215                 220                 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser 
225                 230                 235                 240 


Asn Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg Pro Gln Ile 
                245                 250                 255     


Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Leu 
            260                 265                 270         


Lys His His Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro 
        275                 280                 285             


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Ser Gly Leu 
    290                 295                 300                 


Cys His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys 
305                 310                 315                 320 


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu Lys Arg Thr 
                325                 330                 335     


Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys 
            340                 345                 350         


Asp Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu Arg Lys His 
        355                 360                 365             


Thr Lys Ile His Leu 
    370             


<210>  58
<211>  471
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  58

Met Asp Ala Lys Ser Leu Thr Ala Trp Ser Arg Thr Leu Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Phe Val Asp Phe Thr Arg Glu Glu Trp Lys Leu Leu Asp 
            20                  25                  30          


Thr Ala Gln Gln Ile Val Tyr Arg Asn Val Met Leu Glu Asn Tyr Lys 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Tyr Gln Leu Thr Lys Pro Asp Val Ile Leu 
    50                  55                  60                  


Arg Leu Glu Lys Gly Glu Glu Pro Trp Leu Val Glu Arg Glu Ile His 
65                  70                  75                  80  


Gln Glu Thr His Pro Asp Ser Glu Thr Ala Phe Glu Ile Lys Ser Ser 
                85                  90                  95      


Val Ser Ser Arg Ser Ile Phe Lys Asp Lys Gln Ser Cys Asp Ile Lys 
            100                 105                 110         


Met Glu Gly Met Ala Arg Asn Asp Leu Trp Tyr Leu Ser Leu Glu Glu 
        115                 120                 125             


Val Trp Lys Cys Arg Asp Gln Leu Asp Lys Tyr Gln Glu Asn Pro Glu 
    130                 135                 140                 


Arg His Leu Arg Gln Val Ala Phe Thr Gln Lys Lys Val Leu Thr Gln 
145                 150                 155                 160 


Glu Arg Val Ser Glu Ser Gly Lys Tyr Gly Gly Asn Cys Leu Leu Pro 
                165                 170                 175     


Ala Gln Leu Val Leu Arg Glu Tyr Phe His Lys Arg Asp Ser His Thr 
            180                 185                 190         


Lys Ser Leu Lys His Asp Leu Val Leu Asn Gly His Gln Asp Ser Cys 
        195                 200                 205             


Ala Ser Asn Ser Asn Glu Cys Gly Gln Thr Phe Cys Gln Asn Ile His 
    210                 215                 220                 


Leu Ile Gln Phe Ala Arg Thr His Thr Gly Asp Lys Ser Tyr Lys Cys 
225                 230                 235                 240 


Pro Asp Asn Asp Asn Ser Leu Thr His Gly Ser Ser Leu Gly Ile Ser 
                245                 250                 255     


Lys Gly Ile His Arg Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
            260                 265                 270         


Lys Phe Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile His Thr 
        275                 280                 285             


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln 
    290                 295                 300                 


Ser Asn Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg Pro Gln 
305                 310                 315                 320 


Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala 
                325                 330                 335     


Leu Lys His His Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys 
            340                 345                 350         


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Ser Gly 
        355                 360                 365             


Leu Cys His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro 
    370                 375                 380                 


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu Lys Arg 
385                 390                 395                 400 


Thr Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala 
                405                 410                 415     


Cys Asp Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu Arg Lys 
            420                 425                 430         


His Thr Lys Ile His Thr Gly Glu Gln Phe Leu Thr Cys Asn Gln Cys 
        435                 440                 445             


Gly Thr Ala Leu Val Asn Thr Ser Asn Leu Ile Gly Tyr Gln Thr Asn 
    450                 455                 460                 


His Ile Arg Glu Asn Ala Tyr 
465                 470     


<210>  59
<211>  441
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  59

Met Ala Ala Ala Val Leu Thr Asp Arg Ala Gln Val Ser Val Thr Phe 
1               5                   10                  15      


Asp Asp Val Ala Val Thr Phe Thr Lys Glu Glu Trp Gly Gln Leu Asp 
            20                  25                  30          


Leu Ala Gln Arg Thr Leu Tyr Gln Glu Val Met Leu Glu Asn Cys Gly 
        35                  40                  45              


Leu Leu Val Ser Leu Gly Cys Pro Val Pro Lys Ala Glu Leu Ile Cys 
    50                  55                  60                  


His Leu Glu His Gly Gln Glu Pro Trp Thr Arg Lys Glu Asp Leu Ser 
65                  70                  75                  80  


Gln Asp Thr Cys Pro Gly Asp Lys Gly Lys Pro Lys Thr Thr Glu Pro 
                85                  90                  95      


Thr Thr Cys Glu Pro Ala Leu Ser Glu Gly Ile Ser Leu Gln Gly Gln 
            100                 105                 110         


Val Thr Gln Gly Asn Ser Val Asp Ser Gln Leu Gly Gln Ala Glu Asp 
        115                 120                 125             


Gln Asp Gly Leu Ser Glu Met Gln Glu Gly His Phe Arg Pro Gly Ile 
    130                 135                 140                 


Asp Pro Gln Glu Lys Ser Pro Gly Lys Met Ser Pro Glu Cys Asp Gly 
145                 150                 155                 160 


Leu Gly Thr Ala Asp Gly Val Cys Ser Arg Ile Gly Gln Glu Gln Val 
                165                 170                 175     


Ser Pro Gly Asp Arg Val Arg Ser His Asn Ser Cys Glu Ser Gly Lys 
            180                 185                 190         


Asp Pro Met Ile Gln Glu Glu Glu Asn Asn Phe Ala Cys Asp Ile Cys 
        195                 200                 205             


Gly Arg Lys Phe Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile 
    210                 215                 220                 


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
225                 230                 235                 240 


Ala Gln Ser Asn Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg 
                245                 250                 255     


Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
            260                 265                 270         


Phe Ala Leu Lys His His Leu Leu Asn His Thr Arg Ile His Thr Gly 
        275                 280                 285             


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser 
    290                 295                 300                 


Ser Gly Leu Cys His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile 
305                 310                 315                 320 


Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu 
                325                 330                 335     


Lys Arg Thr Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro 
            340                 345                 350         


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu 
        355                 360                 365             


Arg Lys His Thr Lys Ile His Thr Gly Lys Asn Pro Ile Ser Val Thr 
    370                 375                 380                 


Asp Val Gly Arg Pro Phe Thr Ser Gly Gln Thr Ser Val Thr Leu Arg 
385                 390                 395                 400 


Glu Leu Leu Leu Gly Lys Asp Phe Leu Asn Val Thr Thr Glu Ala Asn 
                405                 410                 415     


Ile Leu Pro Glu Glu Thr Ser Ser Ser Ala Ser Asp Gln Pro Tyr Gln 
            420                 425                 430         


Arg Glu Thr Pro Gln Val Ser Ser Leu 
        435                 440     


<210>  60
<211>  479
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  60

Met Ala Phe Glu Asp Val Ala Val Tyr Phe Ser Gln Glu Glu Trp Gly 
1               5                   10                  15      


Leu Leu Asp Thr Ala Gln Arg Ala Leu Tyr Arg Arg Val Met Leu Asp 
            20                  25                  30          


Asn Phe Ala Leu Val Ala Ser Leu Gly Leu Ser Thr Ser Arg Pro Arg 
        35                  40                  45              


Val Val Ile Gln Leu Glu Arg Gly Glu Glu Pro Trp Val Pro Ser Gly 
    50                  55                  60                  


Thr Asp Thr Thr Leu Ser Arg Thr Thr Tyr Arg Arg Arg Asn Pro Gly 
65                  70                  75                  80  


Ser Trp Ser Leu Thr Glu Asp Arg Asp Val Ser Gly Glu Trp Pro Arg 
                85                  90                  95      


Ala Phe Pro Asp Thr Pro Pro Gly Met Thr Thr Ser Val Phe Pro Val 
            100                 105                 110         


Ala Gly Ala Cys His Ser Val Lys Ser Leu Gln Arg Gln Arg Gly Ala 
        115                 120                 125             


Ser Pro Ser Arg Glu Arg Lys Pro Thr Gly Val Ser Val Ile Tyr Trp 
    130                 135                 140                 


Glu Arg Leu Leu Leu Gly Ser Gly Ser Gly Gln Ala Ser Val Ser Leu 
145                 150                 155                 160 


Arg Leu Thr Ser Pro Leu Arg Pro Pro Glu Gly Val Arg Leu Arg Glu 
                165                 170                 175     


Lys Thr Leu Thr Glu His Ala Leu Leu Gly Arg Gln Pro Arg Thr Pro 
            180                 185                 190         


Glu Arg Gln Lys Pro Cys Ala Gln Glu Val Pro Gly Arg Thr Phe Gly 
        195                 200                 205             


Ser Ala Gln Asp Leu Glu Ala Ala Gly Gly Arg Gly His His Arg Met 
    210                 215                 220                 


Gly Ala Val Trp Gln Glu Pro His Arg Leu Leu Gly Gly Gln Glu Pro 
225                 230                 235                 240 


Ser Thr Trp Asp Glu Leu Gly Glu Ala Leu His Ala Gly Glu Lys Ser 
                245                 250                 255     


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Arg Lys Phe Asn Leu 
            260                 265                 270         


Leu Arg His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
        275                 280                 285             


Ile Cys Gly Arg Lys Phe Ala Gln Ser Asn Thr Leu Arg Thr His Thr 
    290                 295                 300                 


Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Cys Gly Arg Lys Phe Ala Leu Lys His His Leu Leu Asn His 
                325                 330                 335     


Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly 
            340                 345                 350         


Arg Lys Phe Ala Thr Ser Ser Gly Leu Cys His His Thr Lys Ile His 
        355                 360                 365             


Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys 
    370                 375                 380                 


Gly Arg Lys Phe Ala Glu Lys Arg Thr Leu Leu Asn His Thr Arg Ile 
385                 390                 395                 400 


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
                405                 410                 415     


Ala Trp Lys Val Asp Leu Arg Lys His Thr Lys Ile His Thr Gly Glu 
            420                 425                 430         


Lys Thr Val Arg Arg Ser Arg Ala Ser Leu His Pro Gln Ala Arg Ser 
        435                 440                 445             


Val Ala Gly Ala Ser Ser Glu Gly Ala Pro Ala Lys Glu Thr Glu Pro 
    450                 455                 460                 


Thr Pro Ala Ser Gly Pro Ala Ala Val Ser Gln Pro Ala Glu Val 
465                 470                 475                 


<210>  61
<211>  392
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  61

Met Asp Val Leu Ala Ser Tyr Ser Ile Phe Gln Glu Leu Gln Leu Val 
1               5                   10                  15      


His Asp Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Thr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Thr Glu Pro Arg 
        35                  40                  45              


Arg Ile Ser Glu Thr Phe Gly Glu Asp Leu Asp Cys Phe Leu His Ala 
    50                  55                  60                  


Ser Pro Pro Pro Cys Ile Glu Glu Ser Phe Arg Arg Leu Asp Pro Leu 
65                  70                  75                  80  


Leu Leu Pro Val Glu Ala Ala Ile Cys Glu Lys Ser Ser Ala Val Asp 
                85                  90                  95      


Ile Leu Leu Ser Arg Asp Lys Leu Leu Ser Glu Thr Cys Leu Ser Leu 
            100                 105                 110         


Gln Pro Ala Ser Ser Ser Leu Asp Ser Tyr Thr Ala Val Asn Gln Ala 
        115                 120                 125             


Gln Leu Asn Ala Val Thr Ser Leu Thr Pro Pro Ser Ser Pro Glu Leu 
    130                 135                 140                 


Ser Arg His Leu Val Lys Thr Ser Gln Thr Leu Ser Ala Val Asp Gly 
145                 150                 155                 160 


Thr Val Thr Leu Lys Leu Val Ala Lys Lys Ala Ala Leu Ser Ser Val 
                165                 170                 175     


Lys Val Gly Gly Val Ala Thr Ala Ala Ala Ala Val Thr Ala Ala Gly 
            180                 185                 190         


Ala Val Lys Ser Gly Gln Ser Asp Ser Asp Gln Gly Gly Leu Gly Ala 
        195                 200                 205             


Glu Ala Cys Pro Glu Asn Lys Lys Arg Val Phe Ala Cys Asp Ile Cys 
    210                 215                 220                 


Gly Arg Lys Phe Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile 
225                 230                 235                 240 


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
                245                 250                 255     


Ala Gln Ser Asn Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg 
            260                 265                 270         


Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
        275                 280                 285             


Phe Ala Leu Lys His His Leu Leu Asn His Thr Arg Ile His Thr Gly 
    290                 295                 300                 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser 
305                 310                 315                 320 


Ser Gly Leu Cys His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile 
                325                 330                 335     


Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu 
            340                 345                 350         


Lys Arg Thr Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro 
        355                 360                 365             


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu 
    370                 375                 380                 


Arg Lys His Thr Lys Ile His Ile 
385                 390         


<210>  62
<211>  379
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  62

Met Asp Leu Lys Leu Lys Asp Cys Glu Phe Trp Tyr Ser Leu His Gly 
1               5                   10                  15      


Gln Val Pro Gly Leu Leu Asp Trp Asp Met Arg Asn Glu Leu Phe Leu 
            20                  25                  30          


Pro Cys Thr Thr Asp Gln Cys Ser Leu Ala Glu Gln Ile Leu Ala Lys 
        35                  40                  45              


Tyr Arg Val Gly Val Met Lys Pro Pro Glu Met Pro Gln Lys Arg Arg 
    50                  55                  60                  


Pro Ser Pro Asp Gly Asp Gly Pro Pro Cys Glu Pro Asn Leu Trp Met 
65                  70                  75                  80  


Trp Val Asp Pro Asn Ile Leu Cys Pro Leu Gly Ser Gln Glu Ala Pro 
                85                  90                  95      


Lys Pro Ser Gly Lys Glu Asp Leu Thr Asn Ile Ser Pro Phe Pro Gln 
            100                 105                 110         


Pro Pro Gln Lys Asp Glu Gly Ser Asn Cys Ser Glu Asp Lys Val Val 
        115                 120                 125             


Glu Ser Leu Pro Ser Ser Ser Ser Glu Gln Ser Pro Leu Gln Lys Gln 
    130                 135                 140                 


Gly Ile His Ser Pro Ser Asp Phe Glu Leu Thr Glu Glu Glu Ala Glu 
145                 150                 155                 160 


Glu Pro Asp Asp Asn Ser Leu Gln Ser Pro Glu Met Lys Cys Tyr Gln 
                165                 170                 175     


Ser Gln Lys Leu Trp Gln Ile Asn Asn Gln Glu Lys Ser Phe Ala Cys 
            180                 185                 190         


Asp Ile Cys Gly Arg Lys Phe Ala Arg Lys Phe Asn Leu Leu Arg His 
        195                 200                 205             


Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly 
    210                 215                 220                 


Arg Lys Phe Ala Gln Ser Asn Thr Leu Arg Thr His Thr Lys Ile His 
225                 230                 235                 240 


Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys 
                245                 250                 255     


Gly Arg Lys Phe Ala Leu Lys His His Leu Leu Asn His Thr Arg Ile 
            260                 265                 270         


His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
        275                 280                 285             


Ala Thr Ser Ser Gly Leu Cys His His Thr Lys Ile His Thr Gln Arg 
    290                 295                 300                 


Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
305                 310                 315                 320 


Phe Ala Glu Lys Arg Thr Leu Leu Asn His Thr Arg Ile His Thr Gly 
                325                 330                 335     


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Trp Lys 
            340                 345                 350         


Val Asp Leu Arg Lys His Thr Lys Ile His Ile Gln Glu Cys Met Ser 
        355                 360                 365             


Gln Pro Glu Leu Leu Thr Ser Leu Phe Asp Leu 
    370                 375                 


<210>  63
<211>  729
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  63

Met Asp Leu Pro Ala Leu Leu Pro Ala Pro Thr Ala Arg Gly Gly Gln 
1               5                   10                  15      


His Gly Gly Gly Pro Gly Pro Leu Arg Arg Ala Pro Ala Pro Leu Gly 
            20                  25                  30          


Ala Ser Pro Ala Arg Arg Arg Leu Leu Leu Val Arg Gly Pro Glu Asp 
        35                  40                  45              


Gly Gly Pro Gly Ala Arg Pro Gly Glu Ala Ser Gly Pro Ser Pro Pro 
    50                  55                  60                  


Pro Ala Glu Asp Asp Ser Asp Gly Asp Ser Phe Leu Val Leu Leu Glu 
65                  70                  75                  80  


Val Pro His Gly Gly Ala Ala Ala Glu Ala Ala Gly Ser Gln Glu Ala 
                85                  90                  95      


Glu Pro Gly Ser Arg Val Asn Leu Ala Ser Arg Pro Glu Gln Gly Pro 
            100                 105                 110         


Ser Gly Pro Ala Ala Pro Pro Gly Pro Gly Val Ala Pro Ala Gly Ala 
        115                 120                 125             


Val Thr Ile Ser Ser Gln Asp Leu Leu Val Arg Leu Asp Arg Gly Val 
    130                 135                 140                 


Leu Ala Leu Ser Ala Pro Pro Gly Pro Ala Thr Ala Gly Ala Ala Ala 
145                 150                 155                 160 


Pro Arg Arg Ala Pro Gln Ala Ser Gly Pro Ser Thr Pro Gly Phe Ala 
                165                 170                 175     


Cys Asp Ile Cys Gly Arg Lys Phe Ala Arg Lys Phe Asn Leu Leu Arg 
            180                 185                 190         


His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys 
        195                 200                 205             


Gly Arg Lys Phe Ala Gln Ser Asn Thr Leu Arg Thr His Thr Lys Ile 
    210                 215                 220                 


His Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile 
225                 230                 235                 240 


Cys Gly Arg Lys Phe Ala Leu Lys His His Leu Leu Asn His Thr Arg 
                245                 250                 255     


Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys 
            260                 265                 270         


Phe Ala Thr Ser Ser Gly Leu Cys His His Thr Lys Ile His Thr Gln 
        275                 280                 285             


Arg Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg 
    290                 295                 300                 


Lys Phe Ala Glu Lys Arg Thr Leu Leu Asn His Thr Arg Ile His Thr 
305                 310                 315                 320 


Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Trp 
                325                 330                 335     


Lys Val Asp Leu Arg Lys His Thr Lys Ile His Ser Arg Arg Gln Asp 
            340                 345                 350         


Leu Leu Pro Gln Leu Glu Ala Pro Ser Ser Leu Thr Pro Ser Ser Glu 
        355                 360                 365             


Leu Ser Ser Pro Gly Gln Ser Glu Leu Thr Asn Met Asp Leu Ala Ala 
    370                 375                 380                 


Leu Phe Ser Asp Thr Pro Ala Asn Ala Ser Gly Ser Ala Gly Gly Ser 
385                 390                 395                 400 


Asp Glu Ala Leu Asn Ser Gly Ile Leu Thr Ile Asp Val Thr Ser Val 
                405                 410                 415     


Ser Ser Ser Leu Gly Gly Asn Leu Pro Ala Asn Asn Ser Ser Leu Gly 
            420                 425                 430         


Pro Met Glu Pro Leu Val Leu Val Ala His Ser Asp Ile Pro Pro Ser 
        435                 440                 445             


Leu Asp Ser Pro Leu Val Leu Gly Thr Ala Ala Thr Val Leu Gln Gln 
    450                 455                 460                 


Gly Ser Phe Ser Val Asp Asp Val Gln Thr Val Ser Ala Gly Ala Leu 
465                 470                 475                 480 


Gly Cys Leu Val Ala Leu Pro Met Lys Asn Leu Ser Asp Asp Pro Leu 
                485                 490                 495     


Ala Leu Thr Ser Asn Ser Asn Leu Ala Ala His Ile Thr Thr Pro Thr 
            500                 505                 510         


Ser Ser Ser Thr Pro Arg Glu Asn Ala Ser Val Pro Glu Leu Leu Ala 
        515                 520                 525             


Pro Ile Lys Val Glu Pro Asp Ser Pro Ser Arg Pro Gly Ala Val Gly 
    530                 535                 540                 


Gln Gln Glu Gly Ser His Gly Leu Pro Gln Ser Thr Leu Pro Ser Pro 
545                 550                 555                 560 


Ala Glu Gln His Gly Ala Gln Asp Thr Glu Leu Ser Ala Gly Thr Gly 
                565                 570                 575     


Asn Phe Tyr Leu Glu Ser Gly Gly Ser Ala Arg Thr Asp Tyr Arg Ala 
            580                 585                 590         


Ile Gln Leu Ala Lys Glu Lys Lys Gln Arg Gly Ala Gly Ser Asn Ala 
        595                 600                 605             


Gly Ala Ser Gln Ser Thr Gln Arg Lys Ile Lys Glu Gly Lys Met Ser 
    610                 615                 620                 


Pro Pro His Phe His Ala Ser Gln Asn Ser Trp Leu Cys Gly Ser Leu 
625                 630                 635                 640 


Val Val Pro Ser Gly Gly Arg Pro Gly Pro Ala Pro Ala Ala Gly Val 
                645                 650                 655     


Gln Cys Gly Ala Gln Gly Val Gln Val Gln Leu Val Gln Asp Asp Pro 
            660                 665                 670         


Ser Gly Glu Gly Val Leu Pro Ser Ala Arg Gly Pro Ala Thr Phe Leu 
        675                 680                 685             


Pro Phe Leu Thr Val Asp Leu Pro Val Tyr Val Leu Gln Glu Val Leu 
    690                 695                 700                 


Pro Ser Ser Gly Gly Pro Ala Gly Pro Glu Ala Thr Gln Phe Pro Gly 
705                 710                 715                 720 


Ser Thr Ile Asn Leu Gln Asp Leu Gln 
                725                 


<210>  64
<211>  56
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  64

Arg Lys Trp Asn Leu Leu Met Arg Ser Thr Asn Leu Arg Asp Tyr Pro 
1               5                   10                  15      


Tyr Leu Leu Arg Asn Glu Arg Ser Lys Leu Arg Arg Arg Val Asp Thr 
            20                  25                  30          


Leu Leu Asp His Leu Ser Asn Leu Arg Lys Asp Pro Ser Ala Leu Ile 
        35                  40                  45              


Arg Arg Leu Asp Val Leu Arg Ala 
    50                  55      


<210>  65
<211>  402
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  65

Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn 
1               5                   10                  15      


Phe Thr Gln Gly Glu Trp Gln Arg Leu Asn Pro Glu Gln Arg Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly 
        35                  40                  45              


Gln Gly Glu Thr Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Gln Gly 
    50                  55                  60                  


Lys Glu Pro Trp Leu Glu Glu Glu Glu Val Leu Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Glu Lys Asn Gly Asp Ile Gly Gly Gln Ile Trp Lys Pro Lys Asp Val 
                85                  90                  95      


Lys Glu Ser Leu Ala Arg Glu Val Pro Ser Ile Asn Lys Glu Thr Leu 
            100                 105                 110         


Thr Thr Gln Lys Gly Val Glu Cys Asp Gly Ser Lys Lys Ile Leu Pro 
        115                 120                 125             


Leu Gly Ile Asp Asp Val Ser Ser Leu Gln His Tyr Val Gln Asn Asn 
    130                 135                 140                 


Ser His Asp Asp Asn Gly Tyr Arg Lys Leu Val Gly Asn Asn Pro Ser 
145                 150                 155                 160 


Lys Phe Val Gly Gln Gln Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
                165                 170                 175     


Ala Arg Lys Trp Asn Leu Leu Met His Thr Arg Ile His Thr Gly Glu 
            180                 185                 190         


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Arg Ser Thr 
        195                 200                 205             


Asn Leu Arg Asp His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro 
    210                 215                 220                 


Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Tyr Pro 
225                 230                 235                 240 


Tyr Leu Leu Arg Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe 
                245                 250                 255     


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu Arg Ser Lys Leu Arg 
            260                 265                 270         


Arg His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro 
        275                 280                 285             


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Arg Val Asp Thr Leu 
    290                 295                 300                 


Leu Asp His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Cys Gly Arg Lys Phe Ala His Leu Ser Asn Leu Arg Lys His Thr 
                325                 330                 335     


Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro Phe Ala Cys 
            340                 345                 350         


Asp Ile Cys Gly Arg Lys Phe Ala Asp Pro Ser Ala Leu Ile Arg His 
        355                 360                 365             


Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly 
    370                 375                 380                 


Arg Lys Phe Ala Arg Leu Asp Val Leu Arg Ala His Thr Lys Ile His 
385                 390                 395                 400 


Ser Arg 
        


<210>  66
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>   zinc finger target sequence

<400>  66
ctggtcgtat ccggggcagc ggagcagg                                          28


<210>  67
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>   zinc finger target sequence

<400>  67
gccaatgggc ggtgcgcggg ggccgggc                                          28


<210>  68
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>   zinc finger target sequence

<400>  68
ggccgcggcg gggcggggca gcggggcg                                          28


<210>  69
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  69
ggggcggccg ccaatcgccg tggtgttg                                          28


<210>  70
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  zinc finger target sequence

<400>  70
ttgaaactga aaatactaca ttatgcta                                          28


<210>  71
<211>  56
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  71

Arg Lys Tyr His Leu Ser Arg Asp Arg Ser Thr Leu Arg Arg Arg Lys 
1               5                   10                  15      


Asp His Leu Arg Asn Phe Pro Tyr Leu Leu Arg Arg Leu Lys His His 
            20                  25                  30          


Leu Leu Arg Glu Arg Ser Lys Leu Arg Arg Leu Lys Gln Thr Leu Gln 
        35                  40                  45              


Val Asp Arg Ser Thr Leu Arg Arg 
    50                  55      


<210>  72
<211>  283
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  72

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
        195                 200                 205             


Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
    210                 215                 220                 


Thr Gly Glu Lys Pro Tyr Arg Cys Ser Trp Glu Gly Cys Glu Trp Arg 
225                 230                 235                 240 


Phe Ala Arg Ser Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly 
                245                 250                 255     


Ala Lys Pro Phe Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser 
            260                 265                 270         


Asp His Leu Ala Leu His Met Lys Arg His Leu 
        275                 280             


<210>  73
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  73

His Arg Cys His Phe Asn Gly Cys Arg Lys Val Tyr Thr Lys Ser Ser 
1               5                   10                  15      


His Leu Lys Ala His Gln Arg Thr His 
            20                  25  


<210>  74
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  74

Phe Lys Cys Ser His Cys Asp Arg Cys Phe Ser Arg Ser Asp His Leu 
1               5                   10                  15      


Ala Leu His Met Lys Arg His 
            20              


<210>  75
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa His Ile Arg Thr His 
            20              


<210>  76
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  76

Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa His Thr Lys Ile His 
            20              


<210>  77
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Glx Xaa Cys Xaa Xaa Cys Xaa Xaa Glx Xaa Xaa Xaa Xaa Xaa Glx Xaa 
1               5                   10                  15      


Xaa His Xaa Xaa Xaa His 
            20          


<210>  78
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Glx Xaa Cys Xaa Xaa Cys Xaa Xaa Glx Xaa Xaa Xaa Xaa Xaa Glx Xaa 
1               5                   10                  15      


Xaa His Xaa Xaa Xaa His 
            20          


<210>  79
<211>  373
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  79

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val Phe Ala Cys Asp Ile Cys Gly Arg Lys 
        195                 200                 205             


Phe Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile His Thr Gly 
    210                 215                 220                 


Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser 
225                 230                 235                 240 


Asn Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg Pro Gln Ile 
                245                 250                 255     


Pro Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Leu 
            260                 265                 270         


Lys His His Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro 
        275                 280                 285             


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Ser Gly Leu 
    290                 295                 300                 


Cys His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys 
305                 310                 315                 320 


Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu Lys Arg Thr 
                325                 330                 335     


Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys 
            340                 345                 350         


Asp Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu Arg Lys His 
        355                 360                 365             


Thr Lys Ile His Leu 
    370             


<210>  80
<211>  472
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  80

Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn 
1               5                   10                  15      


Phe Thr Gln Gly Glu Trp Gln Arg Leu Asn Pro Glu Gln Arg Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly 
        35                  40                  45              


Gln Gly Glu Thr Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Gln Gly 
    50                  55                  60                  


Lys Glu Pro Trp Leu Glu Glu Glu Glu Val Leu Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Glu Lys Asn Gly Asp Ile Gly Gly Gln Ile Trp Lys Pro Lys Asp Val 
                85                  90                  95      


Lys Glu Ser Leu Ala Arg Glu Val Pro Ser Ile Asn Lys Glu Thr Leu 
            100                 105                 110         


Thr Thr Gln Lys Gly Val Glu Cys Asp Gly Ser Lys Lys Ile Leu Pro 
        115                 120                 125             


Leu Gly Ile Asp Asp Val Ser Ser Leu Gln His Tyr Val Gln Asn Asn 
    130                 135                 140                 


Ser His Asp Asp Asn Gly Tyr Arg Lys Leu Val Gly Asn Asn Pro Ser 
145                 150                 155                 160 


Lys Phe Val Gly Gln Gln Leu Lys Cys Asn Ala Cys Arg Lys Leu Phe 
                165                 170                 175     


Ser Ser Lys Ser Arg Leu Gln Ser His Leu Arg Arg His Ala Cys Gln 
            180                 185                 190         


Lys Pro Phe Glu Cys His Ser Cys Gly Arg Ala Phe Gly Glu Lys Trp 
        195                 200                 205             


Lys Leu Asp Lys His Gln Lys Thr His Ala Glu Glu Arg Pro Tyr Lys 
    210                 215                 220                 


Cys Glu Asn Cys Gly Asn Ala Tyr Lys Gln Lys Ser Asn Leu Phe Gln 
225                 230                 235                 240 


His Gln Lys Met His Thr Lys Glu Lys Pro Tyr Gln Cys Lys Thr Cys 
                245                 250                 255     


Gly Lys Ala Phe Ser Trp Lys Ser Ser Cys Ile Asn His Glu Lys Ile 
            260                 265                 270         


His Asn Ala Lys Lys Ser Tyr Gln Cys Asn Glu Cys Glu Lys Ser Phe 
        275                 280                 285             


Arg Gln Asn Ser Thr Leu Ile Gln His Lys Lys Val His Thr Gly Gln 
    290                 295                 300                 


Lys Pro Phe Gln Cys Thr Asp Cys Gly Lys Ala Phe Ile Tyr Lys Ser 
305                 310                 315                 320 


Asp Leu Val Lys His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
                325                 330                 335     


Cys Ser Ile Cys Glu Lys Ala Phe Ser Gln Lys Ser Asn Val Ile Asp 
            340                 345                 350         


His Glu Lys Ile His Thr Gly Lys Arg Ala Tyr Glu Cys Asp Leu Cys 
        355                 360                 365             


Gly Asn Thr Phe Ile Gln Lys Lys Asn Leu Ile Gln His Lys Lys Ile 
    370                 375                 380                 


His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Arg Cys Gly Lys Ala Phe 
385                 390                 395                 400 


Phe Gln Lys Ser Asn Leu His Ser His Gln Lys Thr His Ser Gly Glu 
                405                 410                 415     


Arg Thr Tyr Arg Cys Ser Glu Cys Gly Lys Thr Phe Ile Arg Lys Leu 
            420                 425                 430         


Asn Leu Ser Leu His Lys Lys Thr His Thr Gly Gln Lys Pro Tyr Gly 
        435                 440                 445             


Cys Ser Glu Cys Gly Lys Ala Phe Ala Asp Arg Ser Tyr Leu Val Arg 
    450                 455                 460                 


His Gln Lys Arg Ile His Ser Arg 
465                 470         


<210>  81
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  81

Leu Lys Cys Asn Ala Cys Arg Lys Leu Phe Ser Ser Lys Ser Arg Leu 
1               5                   10                  15      


Gln Ser His Leu Arg Arg His 
            20              


<210>  82
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  82

Tyr Gly Cys Ser Glu Cys Gly Lys Ala Phe Ala Asp Arg Ser Tyr Leu 
1               5                   10                  15      


Val Arg His Gln Lys Arg Ile His 
            20                  


<210>  83
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  83

Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa His Ile Arg Thr His 
            20              


<210>  84
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragmen


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa His Thr Lys Ile His 
            20              


<210>  85
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  85

Glx Xaa Cys Xaa Xaa Cys Xaa Xaa Glx Xaa Xaa Xaa Xaa Xaa Glx Xaa 
1               5                   10                  15      


Xaa His Xaa Xaa Xaa His 
            20          


<210>  86
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  86

Glx Xaa Cys Xaa Xaa Cys Xaa Xaa Glx Xaa Xaa Xaa Xaa Xaa Glx Xaa 
1               5                   10                  15      


Xaa His Xaa Xaa Xaa His 
            20          


<210>  87
<211>  471
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  87

Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn 
1               5                   10                  15      


Phe Thr Gln Gly Glu Trp Gln Arg Leu Asn Pro Glu Gln Arg Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly 
        35                  40                  45              


Gln Gly Glu Thr Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Gln Gly 
    50                  55                  60                  


Lys Glu Pro Trp Leu Glu Glu Glu Glu Val Leu Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Glu Lys Asn Gly Asp Ile Gly Gly Gln Ile Trp Lys Pro Lys Asp Val 
                85                  90                  95      


Lys Glu Ser Leu Ala Arg Glu Val Pro Ser Ile Asn Lys Glu Thr Leu 
            100                 105                 110         


Thr Thr Gln Lys Gly Val Glu Cys Asp Gly Ser Lys Lys Ile Leu Pro 
        115                 120                 125             


Leu Gly Ile Asp Asp Val Ser Ser Leu Gln His Tyr Val Gln Asn Asn 
    130                 135                 140                 


Ser His Asp Asp Asn Gly Tyr Arg Lys Leu Val Gly Asn Asn Pro Ser 
145                 150                 155                 160 


Lys Phe Val Gly Gln Gln Leu Lys Cys Asn Ala Cys Arg Lys Leu Phe 
                165                 170                 175     


Ser Ser Lys Ser Arg Leu Gln Ser His Leu Arg Arg His Ala Cys Gln 
            180                 185                 190         


Lys Pro Phe Glu Cys His Ser Cys Gly Arg Ala Phe Gly Glu Lys Trp 
        195                 200                 205             


Lys Leu Asp Lys His Gln Lys Thr His Ala Glu Glu Arg Pro Tyr Lys 
    210                 215                 220                 


Cys Glu Asn Cys Gly Asn Ala Tyr Lys Gln Lys Ser Asn Leu Phe Gln 
225                 230                 235                 240 


His Gln Lys Met His Thr Lys Glu Lys Pro Tyr Gln Cys Lys Thr Cys 
                245                 250                 255     


Gly Lys Ala Phe Ser Trp Lys Ser Ser Cys Ile Asn His Glu Lys Ile 
            260                 265                 270         


His Asn Ala Lys Lys Ser Tyr Gln Cys Asn Glu Cys Glu Lys Ser Phe 
        275                 280                 285             


Arg Gln Asn Ser Thr Leu Ile Gln His Lys Lys Val His Thr Gly Gln 
    290                 295                 300                 


Lys Pro Phe Gln Cys Thr Asp Cys Gly Lys Ala Phe Ile Tyr Lys Ser 
305                 310                 315                 320 


Asp Leu Val Lys His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
                325                 330                 335     


Cys Ser Ile Cys Glu Lys Ala Phe Ser Gln Lys Ser Asn Val Ile Asp 
            340                 345                 350         


His Glu Lys Ile His Thr Gly Lys Arg Ala Tyr Glu Cys Asp Leu Cys 
        355                 360                 365             


Gly Asn Thr Phe Ile Gln Lys Lys Asn Leu Ile Gln His Lys Lys Ile 
    370                 375                 380                 


His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Arg Cys Gly Lys Ala Phe 
385                 390                 395                 400 


Phe Gln Lys Ser Asn Leu His Ser His Gln Lys Thr His Ser Gly Glu 
                405                 410                 415     


Arg Thr Tyr Arg Cys Ser Glu Cys Gly Lys Thr Phe Ile Arg Lys Leu 
            420                 425                 430         


Asn Leu Ser Leu His Lys Lys Thr His Thr Gly Gln Lys Pro Tyr Gly 
        435                 440                 445             


Cys Ser Glu Cys Gly Lys Ala Phe Ala Asp Arg Ser Tyr Leu Val Arg 
    450                 455                 460                 


His Gln Lys Arg Ile His Ser 
465                 470     


<210>  88
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  88

Leu Lys Cys Asn Ala Cys Arg Lys Leu Phe Ser Ser Lys Ser Arg Leu 
1               5                   10                  15      


Gln Ser His Leu Arg Arg His 
            20              


<210>  89
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  89

Tyr Gly Cys Ser Glu Cys Gly Lys Ala Phe Ala Asp Arg Ser Tyr Leu 
1               5                   10                  15      


Val Arg His Gln Lys Arg Ile His 
            20                  


<210>  90
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  90

Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa His Ile Arg Thr His 
            20              


<210>  91
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa His Thr Lys Ile His 
            20              


<210>  92
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  92

Glx Xaa Cys Xaa Xaa Cys Xaa Xaa Glx Xaa Xaa Xaa Xaa Xaa Glx Xaa 
1               5                   10                  15      


Xaa His Xaa Xaa Xaa His 
            20          


<210>  93
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  93

Glx Xaa Cys Xaa Xaa Cys Xaa Xaa Glx Xaa Xaa Xaa Xaa Xaa Glx Xaa 
1               5                   10                  15      


Xaa His Xaa Xaa Xaa His 
            20          


<210>  94
<211>  341
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic zinc finger

<400>  94

Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn 
1               5                   10                  15      


Phe Thr Gln Gly Glu Trp Gln Arg Leu Asn Pro Glu Gln Arg Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly 
        35                  40                  45              


Gln Gly Glu Thr Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Gln Gly 
    50                  55                  60                  


Lys Glu Pro Trp Leu Glu Glu Glu Glu Val Leu Gly Ser Gly Arg Ala 
65                  70                  75                  80  


Glu Lys Asn Gly Asp Ile Gly Gly Gln Ile Trp Lys Pro Lys Asp Val 
                85                  90                  95      


Lys Glu Ser Leu Ala Arg Glu Val Pro Ser Ile Asn Lys Glu Thr Leu 
            100                 105                 110         


Thr Thr Gln Lys Gly Val Glu Cys Asp Gly Ser Lys Lys Ile Leu Pro 
        115                 120                 125             


Leu Gly Ile Asp Asp Val Ser Ser Leu Gln His Tyr Val Gln Asn Asn 
    130                 135                 140                 


Ser His Asp Asp Asn Gly Tyr Arg Lys Leu Val Gly Asn Asn Pro Ser 
145                 150                 155                 160 


Lys Phe Val Gly Gln Gln Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe 
                165                 170                 175     


Ala Arg Lys Phe Asn Leu Leu Arg His Thr Arg Ile His Thr Gly Glu 
            180                 185                 190         


Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Gln Ser Asn 
        195                 200                 205             


Thr Leu Arg Thr His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro 
    210                 215                 220                 


Pro Lys Pro Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Leu Lys 
225                 230                 235                 240 


His His Leu Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe 
                245                 250                 255     


Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Thr Ser Ser Gly Leu Cys 
            260                 265                 270         


His His Thr Lys Ile His Thr Gln Arg Pro Gln Ile Pro Pro Lys Pro 
        275                 280                 285             


Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Glu Lys Arg Thr Leu 
    290                 295                 300                 


Leu Asn His Thr Arg Ile His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Cys Gly Arg Lys Phe Ala Trp Lys Val Asp Leu Arg Lys His Thr 
                325                 330                 335     


Lys Ile His Ser Arg 
            340     


<210>  95
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  zinc finger fusion protein fragment

<400>  95

Arg Asn Gly Asn Leu Thr Arg 
1               5           


