                         SEQUENCE LISTING

<110>  Omeros Corporation
       Demopulos, Gregory A.
       Dudler, Thomas
       Lynch, Nicholas James
       Schwaeble, Hans-Wilhelm
       Shaffer, Kathleen A.
       Yabuki, Munehisa
 
<120>  Biomarker for Assessing the Risk of Developing Acute Covid-19 and
        Post-Acute Covid-19

<130>  MP.1.0319.PCT

<150>  63/146,479
<151>  2021-02-05

<150>  63/277,361
<151>  2021-11-09

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  725
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (27)..(584)

<400>  1
ggccaggcca gctggacggg cacacc atg agg ctg ctg acc ctc ctg ggc ctt        53
                             Met Arg Leu Leu Thr Leu Leu Gly Leu          
                             1               5                            

ctg tgt ggc tcg gtg gcc acc ccc ttg ggc ccg aag tgg cct gaa cct        101
Leu Cys Gly Ser Val Ala Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro           
10                  15                  20                  25            

gtg ttc ggg cgc ctg gca tcc ccc ggc ttt cca ggg gag tat gcc aat        149
Val Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn           
                30                  35                  40                

gac cag gag cgg cgc tgg acc ctg act gca ccc ccc ggc tac cgc ctg        197
Asp Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu           
            45                  50                  55                    

cgc ctc tac ttc acc cac ttc gac ctg gag ctc tcc cac ctc tgc gag        245
Arg Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser His Leu Cys Glu           
        60                  65                  70                        

tac gac ttc gtc aag ctg agc tcg ggg gcc aag gtg ctg gcc acg ctg        293
Tyr Asp Phe Val Lys Leu Ser Ser Gly Ala Lys Val Leu Ala Thr Leu           
    75                  80                  85                            

tgc ggg cag gag agc aca gac acg gag cgg gcc cct ggc aag gac act        341
Cys Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr           
90                  95                  100                 105           

ttc tac tcg ctg ggc tcc agc ctg gac att acc ttc cgc tcc gac tac        389
Phe Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr           
                110                 115                 120               

tcc aac gag aag ccg ttc acg ggg ttc gag gcc ttc tat gca gcc gag        437
Ser Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu           
            125                 130                 135                   

gac att gac gag tgc cag gtg gcc ccg gga gag gcg ccc acc tgc gac        485
Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys Asp           
        140                 145                 150                       

cac cac tgc cac aac cac ctg ggc ggt ttc tac tgc tcc tgc cgc gca        533
His His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala           
    155                 160                 165                           

ggc tac gtc ctg cac cgt aac aag cgc acc tgc tca gag cag agc ctc        581
Gly Tyr Val Leu His Arg Asn Lys Arg Thr Cys Ser Glu Gln Ser Leu           
170                 175                 180                 185           

tag cctcccctgg agctccggcc tgcccagcag gtcagaagcc agagccagcc             634

tgctggcctc agctccgggt tgggctgaga tggctgtgcc ccaactccca ttcacccacc      694

atggacccaa taataaacct ggccccaccc c                                     725


<210>  2
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185 


<210>  3
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Glu Gln Ser Leu 
                165                 170 


<210>  4
<211>  2460
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (22)..(2082)

<400>  4
ggccagctgg acgggcacac c atg agg ctg ctg acc ctc ctg ggc ctt ctg         51
                        Met Arg Leu Leu Thr Leu Leu Gly Leu Leu           
                        1               5                   10            

tgt ggc tcg gtg gcc acc ccc ttg ggc ccg aag tgg cct gaa cct gtg         99
Cys Gly Ser Val Ala Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val           
                15                  20                  25                

ttc ggg cgc ctg gca tcc ccc ggc ttt cca ggg gag tat gcc aat gac        147
Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp           
            30                  35                  40                    

cag gag cgg cgc tgg acc ctg act gca ccc ccc ggc tac cgc ctg cgc        195
Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg           
        45                  50                  55                        

ctc tac ttc acc cac ttc gac ctg gag ctc tcc cac ctc tgc gag tac        243
Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr           
    60                  65                  70                            

gac ttc gtc aag ctg agc tcg ggg gcc aag gtg ctg gcc acg ctg tgc        291
Asp Phe Val Lys Leu Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys           
75                  80                  85                  90            

ggg cag gag agc aca gac acg gag cgg gcc cct ggc aag gac act ttc        339
Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe           
                95                  100                 105               

tac tcg ctg ggc tcc agc ctg gac att acc ttc cgc tcc gac tac tcc        387
Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser           
            110                 115                 120                   

aac gag aag ccg ttc acg ggg ttc gag gcc ttc tat gca gcc gag gac        435
Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp           
        125                 130                 135                       

att gac gag tgc cag gtg gcc ccg gga gag gcg ccc acc tgc gac cac        483
Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His           
    140                 145                 150                           

cac tgc cac aac cac ctg ggc ggt ttc tac tgc tcc tgc cgc gca ggc        531
His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly           
155                 160                 165                 170           

tac gtc ctg cac cgt aac aag cgc acc tgc tca gcc ctg tgc tcc ggc        579
Tyr Val Leu His Arg Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly           
                175                 180                 185               

cag gtc ttc acc cag agg tct ggg gag ctc agc agc cct gaa tac cca        627
Gln Val Phe Thr Gln Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro           
            190                 195                 200                   

cgg ccg tat ccc aaa ctc tcc agt tgc act tac agc atc agc ctg gag        675
Arg Pro Tyr Pro Lys Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu           
        205                 210                 215                       

gag ggg ttc agt gtc att ctg gac ttt gtg gag tcc ttc gat gtg gag        723
Glu Gly Phe Ser Val Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu           
    220                 225                 230                           

aca cac cct gaa acc ctg tgt ccc tac gac ttt ctc aag att caa aca        771
Thr His Pro Glu Thr Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr           
235                 240                 245                 250           

gac aga gaa gaa cat ggc cca ttc tgt ggg aag aca ttg ccc cac agg        819
Asp Arg Glu Glu His Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg           
                255                 260                 265               

att gaa aca aaa agc aac acg gtg acc atc acc ttt gtc aca gat gaa        867
Ile Glu Thr Lys Ser Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu           
            270                 275                 280                   

tca gga gac cac aca ggc tgg aag atc cac tac acg agc aca gcg cag        915
Ser Gly Asp His Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln           
        285                 290                 295                       

cct tgc cct tat ccg atg gcg cca cct aat ggc cac gtt tca cct gtg        963
Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn Gly His Val Ser Pro Val           
    300                 305                 310                           

caa gcc aaa tac atc ctg aaa gac agc ttc tcc atc ttt tgc gag act       1011
Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr           
315                 320                 325                 330           

ggc tat gag ctt ctg caa ggt cac ttg ccc ctg aaa tcc ttt act gca       1059
Gly Tyr Glu Leu Leu Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala           
                335                 340                 345               

gtt tgt cag aaa gat gga tct tgg gac cgg cca atg ccc gcg tgc agc       1107
Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser           
            350                 355                 360                   

att gtt gac tgt ggc cct cct gat gat cta ccc agt ggc cga gtg gag       1155
Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu           
        365                 370                 375                       

tac atc aca ggt cct gga gtg acc acc tac aaa gct gtg att cag tac       1203
Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr           
    380                 385                 390                           

agc tgt gaa gag acc ttc tac aca atg aaa gtg aat gat ggt aaa tat       1251
Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr           
395                 400                 405                 410           

gtg tgt gag gct gat gga ttc tgg acg agc tcc aaa gga gaa aaa tca       1299
Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser           
                415                 420                 425               

ctc cca gtc tgt gag cct gtt tgt gga cta tca gcc cgc aca aca gga       1347
Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly           
            430                 435                 440                   

ggg cgt ata tat gga ggg caa aag gca aaa cct ggt gat ttt cct tgg       1395
Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp           
        445                 450                 455                       

caa gtc ctg ata tta ggt gga acc aca gca gca ggt gca ctt tta tat       1443
Gln Val Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr           
    460                 465                 470                           

gac aac tgg gtc cta aca gct gct cat gcc gtc tat gag caa aaa cat       1491
Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His           
475                 480                 485                 490           

gat gca tcc gcc ctg gac att cga atg ggc acc ctg aaa aga cta tca       1539
Asp Ala Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser           
                495                 500                 505               

cct cat tat aca caa gcc tgg tct gaa gct gtt ttt ata cat gaa ggt       1587
Pro His Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly           
            510                 515                 520                   

tat act cat gat gct ggc ttt gac aat gac ata gca ctg att aaa ttg       1635
Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu           
        525                 530                 535                       

aat aac aaa gtt gta atc aat agc aac atc acg cct att tgt ctg cca       1683
Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro           
    540                 545                 550                           

aga aaa gaa gct gaa tcc ttt atg agg aca gat gac att gga act gca       1731
Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala           
555                 560                 565                 570           

tct gga tgg gga tta acc caa agg ggt ttt ctt gct aga aat cta atg       1779
Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met           
                575                 580                 585               

tat gtc gac ata ccg att gtt gac cat caa aaa tgt act gct gca tat       1827
Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr           
            590                 595                 600                   

gaa aag cca ccc tat cca agg gga agt gta act gct aac atg ctt tgt       1875
Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys           
        605                 610                 615                       

gct ggc tta gaa agt ggg ggc aag gac agc tgc aga ggt gac agc gga       1923
Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly           
    620                 625                 630                           

ggg gca ctg gtg ttt cta gat agt gaa aca gag agg tgg ttt gtg gga       1971
Gly Ala Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly           
635                 640                 645                 650           

gga ata gtg tcc tgg ggt tcc atg aat tgt ggg gaa gca ggt cag tat       2019
Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr           
                655                 660                 665               

gga gtc tac aca aaa gtt att aac tat att ccc tgg atc gag aac ata       2067
Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile           
            670                 675                 680                   

att agt gat ttt taa cttgcgtgtc tgcagtcaag gattcttcat ttttagaaat       2122
Ile Ser Asp Phe                                                           
        685                                                               

gcctgtgaag accttggcag cgacgtggct cgagaagcat tcatcattac tgtggacatg     2182

gcagttgttg ctccacccaa aaaaacagac tccaggtgag gctgctgtca tttctccact     2242

tgccagttta attccagcct tacccattga ctcaagggga cataaaccac gagagtgaca     2302

gtcatctttg cccacccagt gtaatgtcac tgctcaaatt acatttcatt accttaaaaa     2362

gccagtctct tttcatactg gctgttggca tttctgtaaa ctgcctgtcc atgctctttg     2422

tttttaaact tgttcttatt gaaaaaaaaa aaaaaaaa                             2460


<210>  5
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  6
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln 
                165                 170                 175     


Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr 
    210                 215                 220                 


Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser 
                245                 250                 255     


Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro 
        275                 280                 285             


Met Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu 
305                 310                 315                 320 


Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro 
        355                 360                 365             


Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp 
385                 390                 395                 400 


Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu 
                405                 410                 415     


Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly 
            420                 425                 430         


Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu 
        435                 440                 445             


Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu 
    450                 455                 460                 


Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu 
465                 470                 475                 480 


Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln 
                485                 490                 495     


Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala 
            500                 505                 510         


Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val 
        515                 520                 525             


Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu 
    530                 535                 540                 


Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu 
545                 550                 555                 560 


Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro 
                565                 570                 575     


Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr 
            580                 585                 590         


Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser 
        595                 600                 605             


Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe 
    610                 615                 620                 


Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp 
625                 630                 635                 640 


Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys 
                645                 650                 655     


Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
            660                 665                 670     


<210>  7
<211>  4900
<212>  DNA
<213>  Homo sapiens

<400>  7
cctgtcctgc ctgcctggaa ctctgagcag gctggagtca tggagtcgat tcccagaatc       60

ccagagtcag ggaggctggg ggcaggggca ggtcactgga caaacagatc aaaggtgaga      120

ccagcgtagg actgcagacc aggccaggcc agctggacgg gcacaccatg aggtaggtgg      180

gcgccacagc ctccctgcag ggtgtggggt gggagcacag gcctgggcct caccgcccct      240

gccctgccca taggctgctg accctcctgg gccttctgtg tggctcggtg gccaccccct      300

taggcccgaa gtggcctgaa cctgtgttcg ggcgcctggc atcccccggc tttccagggg      360

agtatgccaa tgaccaggag cggcgctgga ccctgactgc accccccggc taccgcctgc      420

gcctctactt cacccacttc gacctggagc tctcccacct ctgcgagtac gacttcgtca      480

aggtgccgtc agacgggagg gctggggttt ctcagggtcg gggggtcccc aaggagtagc      540

cagggttcag ggacacctgg gagcaggggc caggcttggc caggagggag atcaggcctg      600

ggtcttgcct tcactccctg tgacacctga ccccacagct gagctcgggg gccaaggtgc      660

tggccacgct gtgcgggcag gagagcacag acacggagcg ggcccctggc aaggacactt      720

tctactcgct gggctccagc ctggacatta ccttccgctc cgactactcc aacgagaagc      780

cgttcacggg gttcgaggcc ttctatgcag ccgagggtga gccaagaggg gtcctgcaac      840

atctcagtct gcgcagctgg ctgtgggggt aactctgtct taggccaggc agccctgcct      900

tcagtttccc cacctttccc agggcagggg agaggcctct ggcctgacat catccacaat      960

gcaaagacca aaacagccgt gacctccatt cacatgggct gagtgccaac tctgagccag     1020

ggatctgagg acagcatcgc ctcaagtgac gcagggactg gccgggcgcg gcagctcacg     1080

cctgtaattc cagcactttg ggaggccgag gctggcttga taatttgagg gtcaggagtt     1140

caaggccagc cagggcaaca cggtgaaact ctatctccac taaaactaca aaaattagct     1200

gggcgtggtg gtgcgcacct ggaatcccag ctactaggga ggctgaggca ggagaattgc     1260

ttgaacctgc gaggtggagg ctgcagtgaa cagagattgc accactacac tccacctggg     1320

cgacagacta gactccgtct caaaaaacaa aaaacaaaaa ccacgcaggg ccgagggccc     1380

atttacaagc tgacaaagtg ggccctgcca gcgggagcgc tgcaggatgt ttgattttca     1440

gatcccagtc cctgcagaga ccaactgtgt gacctctggc aagtggctca atttctctgc     1500

tccttagaag ctgctgcaag ggttcagcgc tgtagccccg ccccctgggt ttgattgact     1560

cccctcatta gctgggtgac ctcggccgga cactgaaact cccactggtt taacagaggt     1620

gatgtttgca tctttctccc agcgctgctg ggagcttgca gcgaccctag gcctgtaagg     1680

tgattggccc ggcaccagtc ccgcacccta gacaggacct aggcctcctc tgaggtccac     1740

tctgaggtca tggatctcct gggaggagtc caggctggat cccgcctctt tccctcctga     1800

cggcctgcct ggccctgcct ctcccccaga cattgacgag tgccaggtgg ccccgggaga     1860

ggcgcccacc tgcgaccacc actgccacaa ccacctgggc ggtttctact gctcctgccg     1920

cgcaggctac gtcctgcacc gtaacaagcg cacctgctca ggtgagggag gctgcctggg     1980

ccccaacgca ccctctcctg ggatacccgg ggctcctcag ggccattgct gctctgccca     2040

ggggtgcgga gggcctgggc ctggacactg ggtgcttcta ggccctgctg cctccagctc     2100

cccttctcag ccctgcttcc cctctcagca gccaggctca tcagtgccac cctgccctag     2160

cactgagact aattctaaca tcccactgtg tacctggttc cacctgggct ctgggaaccc     2220

ctcatgtagc cacgggagag tcggggtatc taccctcgtt ccttggactg ggttcctgtt     2280

ccctgcactg ggggacgggc cagtgctctg gggcgtgggc agccccaccc tgtggcgctg     2340

accctgctcc cccgactcgg tttctcctct cggggtctct ccttgcctct ctgatctctc     2400

ttccagagca gagcctctag cctcccctgg agctccggct gcccagcagg tcagaagcca     2460

gagccaggct gctggcctca gctccgggtt gggctgagat gctgtgcccc aactcccatt     2520

cacccaccat ggacccaata ataaacctgg ccccacccca cctgctgccg cgtgtctctg     2580

gggtgggagg gtcgggaggc ggtggggcgc gctcctctct gcctaccctc ctcacagcct     2640

catgaacccc aggtctgtgg gagcctcctc catggggcca cacggtcctt ggcctcaccc     2700

cctgttttga agatggggca ctgaggccgg agaggggtaa ggcctcgctc gagtccaggt     2760

ccccagaggc tgagcccaga gtaatcttga accaccccca ttcagggtct ggcctggagg     2820

agcctgaccc acagaggaga caccctggga gatattcatt gaggggtaat ctggtccccc     2880

gcaaatccag gggtgattcc cactgcccca taggcacagc cacgtggaag aaggcaggca     2940

atgttggggc tcctcacttc ctagaggcct cacaactcaa atgcccccca ctgcagctgg     3000

gggtggggtg gtggtatggg atggggacca agccttcctt gaaggataga gcccagccca     3060

acaccccgcc ccgtggcagc agcatcacgt gttccagcga ggaaggagag caccagactc     3120

agtcatgatc actgttgcct tgaacttcca agaacagccc cagggcaagg gtcaaaacag     3180

gggaaagggg gtgatgagag atccttcttc cggatgttcc tccaggaacc agggggctgg     3240

ctggtcttgg ctgggttcgg gtaggagacc catgatgaat aaacttggga atcactgggg     3300

tggctgtaag ggaatttagg ggagctccga aggggccctt aggctcgagg agatgctcct     3360

ctcttttccc gaattcccag ggacccagga gagtgtccct tcttcctctt cctgtgtgtc     3420

catccacccc cgccccccgc cctggcagag ctggtggaac tcagtgctct agcccctacc     3480

ctggggttgc gactctggct caggacacca ccacgctccc tgggggtgtg agtgagggcc     3540

tgtgcgctcc atcccgagtg ctgcctgttt cagctaaagc ctcaaagcaa gagaaacccc     3600

ctctctaagc ggcccctcag ccatcgggtg ggtcgtttgg tttctgggta ggcctcaggg     3660

gctggccacc tgcagggccc agcccaaccc agggatgcag atgtcccagc cacatccctg     3720

tcccagtttc ctgctcccca aggcatccac cctgctgttg gtgcgagggc tgatagaggg     3780

cacgccaagt cactcccctg cccttccctc cttccagccc tgtgctccgg ccaggtcttc     3840

acccagaggt ctggggagct cagcagccct gaatacccac ggccgtatcc caaactctcc     3900

agttgcactt acagcatcag cctggaggag gggttcagtg tcattctgga ctttgtggag     3960

tccttcgatg tggagacaca ccctgaaacc ctgtgtccct acgactttct caaggtctgg     4020

ctcctgggcc cctcatcttg tcccagatcc tcccccttca gcccagctgc accccctact     4080

tcctgcagca tggcccccac cacgttcccg tcaccctcgg tgaccccacc tcttcaggtg     4140

ctctatggag gtcaaggctg gggcttcgag tacaagtgtg ggaggcagag tggggagggg     4200

caccccaatc catggcctgg gttggcctca ttggctgtcc ctgaaatgct gaggaggtgg     4260

gttacttccc tccgcccagg ccagacccag gcagctgctc cccagctttc atgagcttct     4320

ttctcagatt caaacagaca gagaagaaca tggcccattc tgtgggaaga cattgcccca     4380

caggattgaa acaaaaagca acacggtgac catcaccttt gtcacagatg aatcaggaga     4440

ccacacaggc tggaagatcc actacacgag cacagtgagc aagtgggctc agatccttgg     4500

tggaagcgca gagctgcctc tctctggagt gcaaggagct gtagagtgta gggctcttct     4560

gggcaggact aggaagggac accaggttta gtggtgctga ggtctgaggc agcagcttct     4620

aaggggaagc acccgtgccc tcctcagcag cacccagcat cttcaccact cattcttcaa     4680

ccacccattc acccatcact catcttttac ccacccaccc tttgccactc atccttctgt     4740

ccctcatcct tccaaccatt catcaatcac ccacccatcc atcctttgcc acacaaccat     4800

ccacccattc ttctacctac ccatcctatc catccatcct tctatcagca tccttctacc     4860

acccatcctt cgttcggtca tccatcatca tccatccatc                           4900


<210>  8
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala 
    130                 135     


<210>  9
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser 
            180     


<210>  10
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr 
    290             


<210>  11
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys 
1               5                   10                  15      


Asp His His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg 
            20                  25                  30          


Ala Gly Tyr Val Leu His Arg Asn Lys 
        35                  40      


<210>  12
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val 
1               5                   10                  15      


Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn 
            20                  25                  30          


Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala 
        35                  40                  45              


Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His 
    50                  55                  60                  


Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr 
65                  70                  75                  80  


His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn 
                85                  90                  95      


Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys 
            100                 105                 110         


Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly 
        115                 120                 125             


Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val 
    130                 135                 140                 


Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys 
145                 150                 155                 160 


Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly 
                165                 170                 175     


Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala 
            180                 185                 190         


Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile 
        195                 200                 205             


Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val 
    210                 215                 220                 


Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser 
225                 230                 235                 240 


Asp Phe 
        


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Lys Asp Ser Cys Arg Gly Asp Ala Gly Gly Ala Leu Val Phe Leu 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu 
1               5                   10                  15  


<210>  15
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe Asp 
1               5                   10                  15      


Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser Ser 
            20                  25                  30          


Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln 
        35                  40              


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Thr Phe Arg Ser Asp Tyr Ser Asn 
1               5               


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Phe Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr 
1               5                   10                  15      


Ser Asn Glu Lys Pro Phe Thr Gly Phe 
            20                  25  


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ile Asp Glu Cys Gln Val Ala Pro Gly 
1               5                   


<210>  19
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys 
1               5                   10                  15      


Arg Gly Asp Ser Gly Gly Ala Leu Val 
            20                  25  


<210>  20
<211>  960
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (51)..(797)

<400>  20
attaactgag attaaccttc cctgagtttt ctcacaccaa ggtgaggacc atg tcc          56
                                                       Met Ser            
                                                       1                  

ctg ttt cca tca ctc cct ctc ctt ctc ctg agt atg gtg gca gcg tct        104
Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala Ala Ser           
        5                   10                  15                        

tac tca gaa act gtg acc tgt gag gat gcc caa aag acc tgc cct gca        152
Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala           
    20                  25                  30                            

gtg att gcc tgt agc tct cca ggc atc aac ggc ttc cca ggc aaa gat        200
Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp           
35                  40                  45                  50            

ggg cgt gat ggc acc aag gga gaa aag ggg gaa cca ggc caa ggg ctc        248
Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu           
                55                  60                  65                

aga ggc tta cag ggc ccc cct gga aag ttg ggg cct cca gga aat cca        296
Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro           
            70                  75                  80                    

ggg cct tct ggg tca cca gga cca aag ggc caa aaa gga gac cct gga        344
Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly           
        85                  90                  95                        

aaa agt ccg gat ggt gat agt agc ctg gct gcc tca gaa aga aaa gct        392
Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala           
    100                 105                 110                           

ctg caa aca gaa atg gca cgt atc aaa aag tgg ctc acc ttc tct ctg        440
Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu           
115                 120                 125                 130           

ggc aaa caa gtt ggg aac aag ttc ttc ctg acc aat ggt gaa ata atg        488
Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met           
                135                 140                 145               

acc ttt gaa aaa gtg aag gcc ttg tgt gtc aag ttc cag gcc tct gtg        536
Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val           
            150                 155                 160                   

gcc acc ccc agg aat gct gca gag aat gga gcc att cag aat ctc atc        584
Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile           
        165                 170                 175                       

aag gag gaa gcc ttc ctg ggc atc act gat gag aag aca gaa ggg cag        632
Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln           
    180                 185                 190                           

ttt gtg gat ctg aca gga aat aga ctg acc tac aca aac tgg aac gag        680
Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu           
195                 200                 205                 210           

ggt gaa ccc aac aat gct ggt tct gat gaa gat tgt gta ttg cta ctg        728
Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu           
                215                 220                 225               

aaa aat ggc cag tgg aat gac gtc ccc tgc tcc acc tcc cat ctg gcc        776
Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala           
            230                 235                 240                   

gtc tgt gag ttc cct atc tga agggtcatat cactcaggcc ctccttgtct           827
Val Cys Glu Phe Pro Ile                                                   
        245                                                               

ttttactgca acccacaggc ccacagtatg cttgaaaaga taaattatat caatttcctc      887

atatccagta ttgttccttt tgtgggcaat cactaaaaat gatcactaac agcaccaaca      947

aagcaataat agt                                                         960


<210>  21
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 represents hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 represents hydrophobic residue

<400>  22

Xaa Gly Lys Xaa Gly Pro 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X represents hydroxyproline

<400>  23

Xaa Gly Lys Leu Gly 
1               5   


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (9)..(15)
<223>  Wherein X at positions 9 and 15 represents hydroxyproline

<400>  24

Gly Leu Arg Gly Leu Gln Gly Pro Xaa Gly Lys Leu Gly Pro Xaa Gly 
1               5                   10                  15      


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(27)
<223>  Wherein X at positions 3, 6, 15, 21, 24, 27 represents 
       hydroxyproline

<400>  25

Gly Pro Xaa Gly Pro Xaa Gly Leu Arg Gly Leu Gln Gly Pro Xaa Gly 
1               5                   10                  15      


Lys Leu Gly Pro Xaa Gly Pro Xaa Gly Pro Xaa 
            20                  25          


<210>  26
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Gln Gly Leu Arg Gly Leu Gln Gly Pro Xaa Gly Lys Leu Gly Pro Xaa 
            20                  25                  30          


Gly Asn Xaa Gly Pro Ser Gly Ser Xaa Gly Pro Lys Gly Gln Lys Gly 
        35                  40                  45              


Asp Xaa Gly Lys Ser 
    50              


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(33)
<223>  Wherein X at positions 3, 6, 12, 18, 21, 30, 33 represents 
       hydroxyproline

<400>  27

Gly Ala Xaa Gly Ser Xaa Gly Glu Lys Gly Ala Xaa Gly Pro Gln Gly 
1               5                   10                  15      


Pro Xaa Gly Pro Xaa Gly Lys Met Gly Pro Lys Gly Glu Xaa Gly Asp 
            20                  25                  30          


Xaa 
    


<210>  28
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (3)..(45)
<223>  Wherein X at positions 3, 6, 9, 27, 30, 36, 42, 45 represents 
       hydroxyproline

<400>  28

Gly Cys Xaa Gly Leu Xaa Gly Ala Xaa Gly Asp Lys Gly Glu Ala Gly 
1               5                   10                  15      


Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Xaa Gly Pro Xaa Gly Lys 
            20                  25                  30          


Ala Gly Pro Xaa Gly Pro Asn Gly Ala Xaa Gly Glu Xaa 
        35                  40                  45  


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Leu Gln Arg Ala Leu Glu Ile Leu Pro Asn Arg Val Thr Ile Lys Ala 
1               5                   10                  15      


Asn Arg Pro Phe Leu Val Phe Ile 
            20                  


<210>  30
<211>  559
<212>  DNA
<213>  Homo sapiens

<400>  30
atgaggctgc tgaccctcct gggccttctg tgtggctcgg tggccacccc cttgggcccg       60

aagtggcctg aacctgtgtt cgggcgcctg gcatcccccg gctttccagg ggagtatgcc      120

aatgaccagg agcggcgctg gaccctgact gcaccccccg gctaccgcct gcgcctctac      180

ttcacccact tcgacctgga gctctcccac ctctgcgagt acgacttcgt caagctgagc      240

tcgggggcca aggtgctggc cacgctgtgc gggcaggaga gcacagacac ggagcgggcc      300

cctggcaagg acactttcta ctcgctgggc tccagcctgg acattacctt ccgctccgac      360

tactccaacg agaagccgtt cacggggttc gaggccttct atgcagccga ggacattgac      420

gagtgccagg tggccccggg agaggcgccc acctgcgacc accactgcca caaccacctg      480

ggcggtttct actgctcctg ccgcgcaggc tacgtcctgc accgtaacaa gcgcacctgc      540

tcagccctgt gctccggcc                                                   559


<210>  31
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
cgggcacacc atgaggctgc tgaccctcct gggc                                   34


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gacattacct tccgctccga ctccaacgag aag                                    33


<210>  33
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
agcagccctg aatacccacg gccgtatccc aaa                                    33


<210>  34
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
cgggatccat gaggctgctg accctc                                            26


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ggaattccta ggctgcata                                                    19


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ggaattccta cagggcgct                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
ggaattccta gtagtggat                                                    19


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
tgcggccgct gtaggtgctg tcttt                                             25


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ggaattcact cgttattctc gga                                               23


<210>  40
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
tccgagaata acgagtg                                                      17


<210>  41
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
cattgaaagc tttggggtag aagttgttc                                         29


<210>  42
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
cgcggccgca gctgctcaga gtgtaga                                           27


<210>  43
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
cggtaagctt cactggctca gggaaata                                          28


<210>  44
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
aagaagcttg ccgccaccat ggattggctg tggaact                                37


<210>  45
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
cgggatcctc aaactttctt gtccaccttg g                                      31


<210>  46
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
aagaaagctt gccgccacca tgttctcact agctct                                 36


<210>  47
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
cgggatcctt ctccctctaa cactct                                            26


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Glu Pro Lys Ser Cys Asp Lys Thr His 
1               5                   


<210>  49
<211>  4960
<212>  DNA
<213>  Homo Sapiens

<400>  49
ccggacgtgg tggcgcatgc ctgtaatccc agctactcgg gaggctgagg caggagaatt       60

gctcgaaccc cggaggcaga ggtttggtgg ctcacacctg taatcccagc actttgcgag      120

gctgaggcag gtgcatcgct ttggctcagg agttcaagac cagcctgggc aacacaggga      180

gacccccatc tctacaaaaa acaaaaacaa atataaaggg gataaaaaaa aaaaaaagac      240

aagacatgaa tccatgagga cagagtgtgg aagaggaagc agcagcctca aagttctgga      300

agctggaaga acagataaac aggtgtgaaa taactgcctg gaaagcaact tctttttttt      360

tttttttttt tttgaggtgg agtctcactc tgtcgtccag gctggagtgc agtggtgcga      420

tctcggatca ctgcaacctc cgcctcccag gctcaagcaa ttctcctgcc tcagcctccc      480

gagtagctgg gattataagt gcgcgctgcc acacctggat gatttttgta tttttagtag      540

agatgggatt tcaccatgtt ggtcaggctg gtctcaaact cccaacctcg tgatccaccc      600

accttggcct cccaaagtgc tgggattaca ggtataagcc accgagccca gccaaaagcg      660

acttctaagc ctgcaaggga atcgggaatt ggtggcacca ggtccttctg acagggttta      720

agaaattagc cagcctgagg ctgggcacgg tggctcacac ctgtaatccc agcactttgg      780

gaggctaagg caggtggatc acctgagggc aggagttcaa gaccagcctg accaacatgg      840

agaaacccca tccctaccaa aaataaaaaa ttagccaggt gtggtggtgc tcgcctgtaa      900

tcccagctac ttgggaggct gaggtgggag gattgcttga acacaggaag tagaggctgc      960

agtgagctat gattgcagca ctgcactgaa gccggggcaa cagaacaaga tccaaaaaaa     1020

agggaggggt gaggggcaga gccaggattt gtttccaggc tgttgttacc taggtccgac     1080

tcctggctcc cagagcagcc tgtcctgcct gcctggaact ctgagcaggc tggagtcatg     1140

gagtcgattc ccagaatccc agagtcaggg aggctggggg caggggcagg tcactggaca     1200

aacagatcaa aggtgagacc agcgtagggc tgcagaccag gccaggccag ctggacgggc     1260

acaccatgag gtaggtgggc gcccacagcc tccctgcagg gtgtggggtg ggagcacagg     1320

cctgggccct caccgcccct gccctgccca taggctgctg accctcctgg gccttctgtg     1380

tggctcggtg gccaccccct tgggcccgaa gtggcctgaa cctgtgttcg ggcgcctggc     1440

atcccccggc tttccagggg agtatgccaa tgaccaggag cggcgctgga ccctgactgc     1500

accccccggc taccgcctgc gcctctactt cacccacttc gacctggagc tctcccacct     1560

ctgcgagtac gacttcgtca aggtgccgtc aggacgggag ggctggggtt tctcagggtc     1620

ggggggtccc caaggagtag ccagggttca gggacacctg ggagcagggg ccaggcttgg     1680

ccaggaggga gatcaggcct gggtcttgcc ttcactccct gtgacacctg accccacagc     1740

tgagctcggg ggccaaggtg ctggccacgc tgtgcgggca ggagagcaca gacacggagc     1800

gggcccctgg caaggacact ttctactcgc tgggctccag cctggacatt accttccgct     1860

ccgactactc caacgagaag ccgttcacgg ggttcgaggc cttctatgca gccgagggtg     1920

agccaagagg ggtcctgcaa catctcagtc tgcgcagctg gctgtggggg taactctgtc     1980

ttaggccagg cagccctgcc ttcagtttcc ccacctttcc cagggcaggg gagaggcctc     2040

tggcctgaca tcatccacaa tgcaaagacc aaaacagccg tgacctccat tcacatgggc     2100

tgagtgccaa ctctgagcca gggatctgag gacagcatcg cctcaagtga cgcagggact     2160

ggccgggcgc agcagctcac gcctgtaatt ccagcacttt gggaggccga ggctggctga     2220

tcatttgagg tcaggagttc aaggccagcc agggcaacac ggtgaaactc tatctccact     2280

aaaactacaa aaattagctg ggcgtggtgg tgcgcacctg gaatcccagc tactagggag     2340

gctgaggcag gagaattgct tgaacctgcg aggtggaggc tgcagtgaac agagattgca     2400

ccactacact ccagcctggg cgacagagct agactccgtc tcaaaaaaca aaaaacaaaa     2460

acgacgcagg ggccgagggc cccatttaca gctgacaaag tggggccctg ccagcgggag     2520

cgctgccagg atgtttgatt tcagatccca gtccctgcag agaccaactg tgtgacctct     2580

ggcaagtggc tcaatttctc tgctccttag gaagctgctg caagggttca gcgctgtagc     2640

cccgccccct gggtttgatt gactcccctc attagctggg tgacctcggg ccggacactg     2700

aaactcccac tggtttaaca gaggtgatgt ttgcatcttt ctcccagcgc tgctgggagc     2760

ttgcagcgac cctaggcctg taaggtgatt ggcccggcac cagtcccgca ccctagacag     2820

gacgaggcct cctctgaggt ccactctgag gtcatggatc tcctgggagg agtccaggct     2880

ggatcccgcc tctttccctc ctgacggcct gcctggccct gcctctcccc cagacattga     2940

cgagtgccag gtggccccgg gagaggcgcc cacctgcgac caccactgcc acaaccacct     3000

gggcggtttc tactgctcct gccgcgcagg ctacgtcctg caccgtaaca agcgcacctg     3060

ctcagccctg tgctccggcc aggtcttcac ccagaggtct ggggagctca gcagccctga     3120

atacccacgg ccgtatccca aactctccag ttgcacttac agcatcagcc tggaggaggg     3180

gttcagtgtc attctggact ttgtggagtc cttcgatgtg gagacacacc ctgaaaccct     3240

gtgtccctac gactttctca agattcaaac agacagagaa gaacatggcc cattctgtgg     3300

gaagacattg ccccacagga ttgaaacaaa aagcaacacg gtgaccatca cctttgtcac     3360

agatgaatca ggagaccaca caggctggaa gatccactac acgagcacag cgcacgcttg     3420

cccttatccg atggcgccac ctaatggcca cgtttcacct gtgcaagcca aatacatcct     3480

gaaagacagc ttctccatct tttgcgagac tggctatgag cttctgcaag gtcacttgcc     3540

cctgaaatcc tttactgcag tttgtcagaa agatggatct tgggaccggc caatgcccgc     3600

gtgcagcatt gttgactgtg gccctcctga tgatctaccc agtggccgag tggagtacat     3660

cacaggtcct ggagtgacca cctacaaagc tgtgattcag tacagctgtg aagagacctt     3720

ctacacaatg aaagtgaatg atggtaaata tgtgtgtgag gctgatggat tctggacgag     3780

ctccaaagga gaaaaatcac tcccagtctg tgagcctgtt tgtggactat cagcccgcac     3840

aacaggaggg cgtatatatg gagggcaaaa ggcaaaacct ggtgattttc cttggcaagt     3900

cctgatatta ggtggaacca cagcagcagg tgcactttta tatgacaact gggtcctaac     3960

agctgctcat gccgtctatg agcaaaaaca tgatgcatcc gccctggaca ttcgaatggg     4020

caccctgaaa agactatcac ctcattatac acaagcctgg tctgaagctg tttttataca     4080

tgaaggttat actcatgatg ctggctttga caatgacata gcactgatta aattgaataa     4140

caaagttgta atcaatagca acatcacgcc tatttgtctg ccaagaaaag aagctgaatc     4200

ctttatgagg acagatgaca ttggaactgc atctggatgg ggattaaccc aaaggggttt     4260

tcttgctaga aatctaatgt atgtcgacat accgattgtt gaccatcaaa aatgtactgc     4320

tgcatatgaa aagccaccct atccaagggg aagtgtaact gctaacatgc tttgtgctgg     4380

cttagaaagt gggggcaagg acagctgcag aggtgacagc ggaggggcac tggtgtttct     4440

agatagtgaa acagagaggt ggtttgtggg aggaatagtg tcctggggtt ccatgaattg     4500

tggggaagca ggtcagtatg gagtctacac aaaagttatt aactatattc cctggatcga     4560

gaacataatt agtgattttt aacttgcgtg tctgcagtca aggattcttc atttttagaa     4620

atgcctgtga agaccttggc agcgacgtgg ctcgagaagc attcatcatt actgtggaca     4680

tggcagttgt tgctccaccc aaaaaaacag actccaggtg aggctgctgt catttctcca     4740

cttgccagtt taattccagc cttacccatt gactcaaggg gacataaacc acgagagtga     4800

cagtcatctt tgcccaccca gtgtaatgtc actgctcaaa ttacatttca ttaccttaaa     4860

aagccagtct cttttcatac tggctgttgg catttctgta aactgcctgt ccatgctctt     4920

tgtttttaaa cttgttctta ttgaaaaaaa aaaaaaaaaa                           4960


<210>  50
<211>  2090
<212>  DNA
<213>  Murine


<220>
<221>  CDS
<222>  (33)..(2090)

<400>  50
ggcgctggac tgcagagcta tggtggcaca cc atg agg cta ctc atc ttc ctg         53
                                    Met Arg Leu Leu Ile Phe Leu           
                                    1               5                     

ggt ctg ctg tgg agt ttg gtg gcc aca ctt ctg ggt tca aag tgg cct        101
Gly Leu Leu Trp Ser Leu Val Ala Thr Leu Leu Gly Ser Lys Trp Pro           
        10                  15                  20                        

gaa cct gta ttc ggg cgc ctg gtg tcc cct ggc ttc cca gag aag tat        149
Glu Pro Val Phe Gly Arg Leu Val Ser Pro Gly Phe Pro Glu Lys Tyr           
    25                  30                  35                            

gct gac cat caa gat cga tcc tgg aca ctg act gca ccc cct ggc tac        197
Ala Asp His Gln Asp Arg Ser Trp Thr Leu Thr Ala Pro Pro Gly Tyr           
40                  45                  50                  55            

cgc ctg cgc ctc tac ttc acc cac ttt gac ctg gaa ctc tct tac cgc        245
Arg Leu Arg Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser Tyr Arg           
                60                  65                  70                

tgc gag tat gac ttt gtc aag ttg agc tca ggg acc aag gtg ctg gcc        293
Cys Glu Tyr Asp Phe Val Lys Leu Ser Ser Gly Thr Lys Val Leu Ala           
            75                  80                  85                    

aca ctg tgt ggg cag gag agt aca gac act gag cag gca cct ggc aat        341
Thr Leu Cys Gly Gln Glu Ser Thr Asp Thr Glu Gln Ala Pro Gly Asn           
        90                  95                  100                       

gac acc ttc tac tca ctg ggt ccc agc cta aag gtc acc ttc cac tcc        389
Asp Thr Phe Tyr Ser Leu Gly Pro Ser Leu Lys Val Thr Phe His Ser           
    105                 110                 115                           

gac tac tcc aat gag aag ccg ttc aca ggg ttt gag gcc ttc tat gca        437
Asp Tyr Ser Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala           
120                 125                 130                 135           

gcg gag gat gtg gat gaa tgc aga gtg tct ctg gga gac tca gtc cct        485
Ala Glu Asp Val Asp Glu Cys Arg Val Ser Leu Gly Asp Ser Val Pro           
                140                 145                 150               

tgt gac cat tat tgc cac aac tac ttg ggc ggc tac tat tgc tcc tgc        533
Cys Asp His Tyr Cys His Asn Tyr Leu Gly Gly Tyr Tyr Cys Ser Cys           
            155                 160                 165                   

aga gcg ggc tac att ctc cac cag aac aag cac acg tgc tca gcc ctt        581
Arg Ala Gly Tyr Ile Leu His Gln Asn Lys His Thr Cys Ser Ala Leu           
        170                 175                 180                       

tgt tca ggc cag gtg ttc aca gga aga tct ggg tat ctc agt agc cct        629
Cys Ser Gly Gln Val Phe Thr Gly Arg Ser Gly Tyr Leu Ser Ser Pro           
    185                 190                 195                           

gag tac ccg cag cca tac ccc aag ctc tcc agc tgc acc tac agc atc        677
Glu Tyr Pro Gln Pro Tyr Pro Lys Leu Ser Ser Cys Thr Tyr Ser Ile           
200                 205                 210                 215           

cgc ctg gag gac ggc ttc agt gtc atc ctg gac ttc gtg gag tcc ttc        725
Arg Leu Glu Asp Gly Phe Ser Val Ile Leu Asp Phe Val Glu Ser Phe           
                220                 225                 230               

gat gtg gag acg cac cct gaa gcc cag tgc ccc tat gac tcc ctc aag        773
Asp Val Glu Thr His Pro Glu Ala Gln Cys Pro Tyr Asp Ser Leu Lys           
            235                 240                 245                   

att caa aca gac aag ggg gaa cac ggc cca ttt tgt ggg aag acg ctg        821
Ile Gln Thr Asp Lys Gly Glu His Gly Pro Phe Cys Gly Lys Thr Leu           
        250                 255                 260                       

cct ccc agg att gaa act gac agc cac aag gtg acc atc acc ttt gcc        869
Pro Pro Arg Ile Glu Thr Asp Ser His Lys Val Thr Ile Thr Phe Ala           
    265                 270                 275                           

act gac gag tcg ggg aac cac aca ggc tgg aag ata cac tac aca agc        917
Thr Asp Glu Ser Gly Asn His Thr Gly Trp Lys Ile His Tyr Thr Ser           
280                 285                 290                 295           

aca gca cgg ccc tgc cct gat cca acg gcg cca cct aat ggc agc att        965
Thr Ala Arg Pro Cys Pro Asp Pro Thr Ala Pro Pro Asn Gly Ser Ile           
                300                 305                 310               

tca cct gtg caa gcc acg tat gtc ctg aag gac agg ttt tct gtc ttc       1013
Ser Pro Val Gln Ala Thr Tyr Val Leu Lys Asp Arg Phe Ser Val Phe           
            315                 320                 325                   

tgc aag aca ggc ttc gag ctt ctg caa ggt tct gtc ccc ctg aaa tca       1061
Cys Lys Thr Gly Phe Glu Leu Leu Gln Gly Ser Val Pro Leu Lys Ser           
        330                 335                 340                       

ttc act gct gtc tgt cag aaa gat gga tct tgg gac cgg ccg atg cca       1109
Phe Thr Ala Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro           
    345                 350                 355                           

gag tgc agc att att gat tgt ggc cct ccc gat gac cta ccc aat ggc       1157
Glu Cys Ser Ile Ile Asp Cys Gly Pro Pro Asp Asp Leu Pro Asn Gly           
360                 365                 370                 375           

cat gtg gac tat atc aca ggc cct caa gtg act acc tac aaa gct gtg       1205
His Val Asp Tyr Ile Thr Gly Pro Gln Val Thr Thr Tyr Lys Ala Val           
                380                 385                 390               

att cag tac agc tgt gaa gag act ttc tac aca atg agc agc aat ggt       1253
Ile Gln Tyr Ser Cys Glu Glu Thr Phe Tyr Thr Met Ser Ser Asn Gly           
            395                 400                 405                   

aaa tat gtg tgt gag gct gat gga ttc tgg acg agc tcc aaa gga gaa       1301
Lys Tyr Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu           
        410                 415                 420                       

aaa ctc ccc ccg gtt tgt gag cct gtt tgt ggg ctg tcc aca cac act       1349
Lys Leu Pro Pro Val Cys Glu Pro Val Cys Gly Leu Ser Thr His Thr           
    425                 430                 435                           

ata gga gga cgc ata gtt gga ggg cag cct gca aag cct ggt gac ttt       1397
Ile Gly Gly Arg Ile Val Gly Gly Gln Pro Ala Lys Pro Gly Asp Phe           
440                 445                 450                 455           

cct tgg caa gtc ttg ttg ctg ggt caa act aca gca gca gca ggt gca       1445
Pro Trp Gln Val Leu Leu Leu Gly Gln Thr Thr Ala Ala Ala Gly Ala           
                460                 465                 470               

ctt ata cat gac aat tgg gtc cta aca gcc gct cat gct gta tat gag       1493
Leu Ile His Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu           
            475                 480                 485                   

aaa aga atg gca gcg tcc tcc ctg aac atc cga atg ggc atc ctc aaa       1541
Lys Arg Met Ala Ala Ser Ser Leu Asn Ile Arg Met Gly Ile Leu Lys           
        490                 495                 500                       

agg ctc tca cct cat tac act caa gcc tgg ccc gag gaa atc ttt ata       1589
Arg Leu Ser Pro His Tyr Thr Gln Ala Trp Pro Glu Glu Ile Phe Ile           
    505                 510                 515                           

cat gaa ggc tac act cac ggt gct ggt ttt gac aat gat ata gca ttg       1637
His Glu Gly Tyr Thr His Gly Ala Gly Phe Asp Asn Asp Ile Ala Leu           
520                 525                 530                 535           

att aaa ctc aag aac aaa gtc aca atc aac gga agc atc atg cct gtt       1685
Ile Lys Leu Lys Asn Lys Val Thr Ile Asn Gly Ser Ile Met Pro Val           
                540                 545                 550               

tgc cta ccg cga aaa gaa gct gca tcc tta atg aga aca gac ttc act       1733
Cys Leu Pro Arg Lys Glu Ala Ala Ser Leu Met Arg Thr Asp Phe Thr           
            555                 560                 565                   

gga act gtg gct ggc tgg ggg tta acc cag aag ggg ctt ctt gct aga       1781
Gly Thr Val Ala Gly Trp Gly Leu Thr Gln Lys Gly Leu Leu Ala Arg           
        570                 575                 580                       

aac cta atg ttt gtg gac ata cca att gct gac cac caa aaa tgt acc       1829
Asn Leu Met Phe Val Asp Ile Pro Ile Ala Asp His Gln Lys Cys Thr           
    585                 590                 595                           

acc gtg tat gaa aag ctc tat cca gga gta aga gta agc gct aac atg       1877
Thr Val Tyr Glu Lys Leu Tyr Pro Gly Val Arg Val Ser Ala Asn Met           
600                 605                 610                 615           

ctc tgt gct ggc tta gag act ggt ggc aag gac agc tgc aga ggt gac       1925
Leu Cys Ala Gly Leu Glu Thr Gly Gly Lys Asp Ser Cys Arg Gly Asp           
                620                 625                 630               

agt ggg ggg gca tta gtg ttt cta gat aat gag aca cag cga tgg ttt       1973
Ser Gly Gly Ala Leu Val Phe Leu Asp Asn Glu Thr Gln Arg Trp Phe           
            635                 640                 645                   

gtg gga gga ata gtt tcc tgg ggt tcc att aat tgt ggg gcg gca ggc       2021
Val Gly Gly Ile Val Ser Trp Gly Ser Ile Asn Cys Gly Ala Ala Gly           
        650                 655                 660                       

cag tat ggg gtc tac aca aaa gtc atc aac tat att ccc tgg aat gag       2069
Gln Tyr Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Asn Glu           
    665                 670                 675                           

aac ata ata agt aat ttc taa                                           2090
Asn Ile Ile Ser Asn Phe                                                   
680                 685                                                   


<210>  51
<211>  685
<212>  PRT
<213>  Murine

<400>  51

Met Arg Leu Leu Ile Phe Leu Gly Leu Leu Trp Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val Ser 
            20                  25                  30          


Pro Gly Phe Pro Glu Lys Tyr Ala Asp His Gln Asp Arg Ser Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Gln Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro Ser 
            100                 105                 110         


Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg Val 
    130                 135                 140                 


Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr Leu 
145                 150                 155                 160 


Gly Gly Tyr Tyr Cys Ser Cys Arg Ala Gly Tyr Ile Leu His Gln Asn 
                165                 170                 175     


Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly Arg 
            180                 185                 190         


Ser Gly Tyr Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Arg Leu Glu Asp Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Ala Gln 
225                 230                 235                 240 


Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Gly Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser His 
            260                 265                 270         


Lys Val Thr Ile Thr Phe Ala Thr Asp Glu Ser Gly Asn His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Arg Pro Cys Pro Asp Pro Thr 
    290                 295                 300                 


Ala Pro Pro Asn Gly Ser Ile Ser Pro Val Gln Ala Thr Tyr Val Leu 
305                 310                 315                 320 


Lys Asp Arg Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu Gln 
                325                 330                 335     


Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Glu Cys Ser Ile Ile Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro Gln 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe 
                405                 410                 415     


Trp Thr Ser Ser Lys Gly Glu Lys Leu Pro Pro Val Cys Glu Pro Val 
            420                 425                 430         


Cys Gly Leu Ser Thr His Thr Ile Gly Gly Arg Ile Val Gly Gly Gln 
        435                 440                 445             


Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly Gln 
    450                 455                 460                 


Thr Thr Ala Ala Ala Gly Ala Leu Ile His Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Lys Arg Met Ala Ala Ser Ser Leu Asn 
                485                 490                 495     


Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Pro Glu Glu Ile Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile 
    530                 535                 540                 


Asn Gly Ser Ile Met Pro Val Cys Leu Pro Arg Lys Glu Ala Ala Ser 
545                 550                 555                 560 


Leu Met Arg Thr Asp Phe Thr Gly Thr Val Ala Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Lys Gly Leu Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile 
            580                 585                 590         


Ala Asp His Gln Lys Cys Thr Thr Val Tyr Glu Lys Leu Tyr Pro Gly 
        595                 600                 605             


Val Arg Val Ser Ala Asn Met Leu Cys Ala Gly Leu Glu Thr Gly Gly 
    610                 615                 620                 


Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp 
625                 630                 635                 640 


Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser 
                645                 650                 655     


Ile Asn Cys Gly Ala Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val Ile 
            660                 665                 670         


Asn Tyr Ile Pro Trp Asn Glu Asn Ile Ile Ser Asn Phe 
        675                 680                 685 


<210>  52
<211>  670
<212>  PRT
<213>  Murine

<400>  52

Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val 
1               5                   10                  15      


Ser Pro Gly Phe Pro Glu Lys Tyr Ala Asp His Gln Asp Arg Ser Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Gln Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro 
                85                  90                  95      


Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg 
        115                 120                 125             


Val Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr 
    130                 135                 140                 


Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Ala Gly Tyr Ile Leu His Gln 
145                 150                 155                 160 


Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly 
                165                 170                 175     


Arg Ser Gly Tyr Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Arg Leu Glu Asp Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Ala 
    210                 215                 220                 


Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Gly Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser 
                245                 250                 255     


His Lys Val Thr Ile Thr Phe Ala Thr Asp Glu Ser Gly Asn His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Arg Pro Cys Pro Asp Pro 
        275                 280                 285             


Thr Ala Pro Pro Asn Gly Ser Ile Ser Pro Val Gln Ala Thr Tyr Val 
    290                 295                 300                 


Leu Lys Asp Arg Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu 
305                 310                 315                 320 


Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Met Pro Glu Cys Ser Ile Ile Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro 
        355                 360                 365             


Gln Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly 
385                 390                 395                 400 


Phe Trp Thr Ser Ser Lys Gly Glu Lys Leu Pro Pro Val Cys Glu Pro 
                405                 410                 415     


Val Cys Gly Leu Ser Thr His Thr Ile Gly Gly Arg Ile Val Gly Gly 
            420                 425                 430         


Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly 
        435                 440                 445             


Gln Thr Thr Ala Ala Ala Gly Ala Leu Ile His Asp Asn Trp Val Leu 
    450                 455                 460                 


Thr Ala Ala His Ala Val Tyr Glu Lys Arg Met Ala Ala Ser Ser Leu 
465                 470                 475                 480 


Asn Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Pro His Tyr Thr Gln 
                485                 490                 495     


Ala Trp Pro Glu Glu Ile Phe Ile His Glu Gly Tyr Thr His Gly Ala 
            500                 505                 510         


Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr 
        515                 520                 525             


Ile Asn Gly Ser Ile Met Pro Val Cys Leu Pro Arg Lys Glu Ala Ala 
    530                 535                 540                 


Ser Leu Met Arg Thr Asp Phe Thr Gly Thr Val Ala Gly Trp Gly Leu 
545                 550                 555                 560 


Thr Gln Lys Gly Leu Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro 
                565                 570                 575     


Ile Ala Asp His Gln Lys Cys Thr Thr Val Tyr Glu Lys Leu Tyr Pro 
            580                 585                 590         


Gly Val Arg Val Ser Ala Asn Met Leu Cys Ala Gly Leu Glu Thr Gly 
        595                 600                 605             


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
    610                 615                 620                 


Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
625                 630                 635                 640 


Ser Ile Asn Cys Gly Ala Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
                645                 650                 655     


Ile Asn Tyr Ile Pro Trp Asn Glu Asn Ile Ile Ser Asn Phe 
            660                 665                 670 


<210>  53
<211>  2091
<212>  DNA
<213>  Rat


<220>
<221>  CDS
<222>  (10)..(2067)

<400>  53
tggcacaca atg agg cta ctg atc gtc ctg ggt ctg ctt tgg agt ttg gtg       51
          Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val         
          1               5                   10                          

gcc aca ctt ttg ggc tcc aag tgg cct gag cct gta ttc ggg cgc ctg         99
Ala Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu           
15                  20                  25                  30            

gtg tcc ctg gcc ttc cca gag aag tat ggc aac cat cag gat cga tcc        147
Val Ser Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser           
                35                  40                  45                

tgg acg ctg act gca ccc cct ggc ttc cgc ctg cgc ctc tac ttc acc        195
Trp Thr Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr           
            50                  55                  60                    

cac ttc aac ctg gaa ctc tct tac cgc tgc gag tat gac ttt gtc aag        243
His Phe Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys           
        65                  70                  75                        

ttg acc tca ggg acc aag gtg cta gcc acg ctg tgt ggg cag gag agt        291
Leu Thr Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser           
    80                  85                  90                            

aca gat act gag cgg gca cct ggc aat gac acc ttc tac tca ctg ggt        339
Thr Asp Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly           
95                  100                 105                 110           

ccc agc cta aag gtc acc ttc cac tcc gac tac tcc aat gag aag cca        387
Pro Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro           
                115                 120                 125               

ttc aca gga ttt gag gcc ttc tat gca gcg gag gat gtg gat gaa tgc        435
Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys           
            130                 135                 140                   

aga aca tcc ctg gga gac tca gtc cct tgt gac cat tat tgc cac aac        483
Arg Thr Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn           
        145                 150                 155                       

tac ctg ggc ggc tac tac tgc tcc tgc cga gtg ggc tac att ctg cac        531
Tyr Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His           
    160                 165                 170                           

cag aac aag cat acc tgc tca gcc ctt tgt tca ggc cag gtg ttc act        579
Gln Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr           
175                 180                 185                 190           

ggg agg tct ggc ttt ctc agt agc cct gag tac cca cag cca tac ccc        627
Gly Arg Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro           
                195                 200                 205               

aaa ctc tcc agc tgc gcc tac aac atc cgc ctg gag gaa ggc ttc agt        675
Lys Leu Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser           
            210                 215                 220                   

atc acc ctg gac ttc gtg gag tcc ttt gat gtg gag atg cac cct gaa        723
Ile Thr Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu           
        225                 230                 235                       

gcc cag tgc ccc tac gac tcc ctc aag att caa aca gac aag agg gaa        771
Ala Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu           
    240                 245                 250                           

tac ggc ccg ttt tgt ggg aag acg ctg ccc ccc agg att gaa act gac        819
Tyr Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp           
255                 260                 265                 270           

agc aac aag gtg acc att acc ttt acc acc gac gag tca ggg aac cac        867
Ser Asn Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His           
                275                 280                 285               

aca ggc tgg aag ata cac tac aca agc aca gca cag ccc tgc cct gat        915
Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp           
            290                 295                 300                   

cca acg gcg cca cct aat ggt cac att tca cct gtg caa gcc acg tat        963
Pro Thr Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr           
        305                 310                 315                       

gtc ctg aag gac agc ttt tct gtc ttc tgc aag act ggc ttc gag ctt       1011
Val Leu Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu           
    320                 325                 330                           

ctg caa ggt tct gtc ccc ctg aag tca ttc act gct gtc tgt cag aaa       1059
Leu Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys           
335                 340                 345                 350           

gat gga tct tgg gac cgg ccg ata cca gag tgc agc att att gac tgt       1107
Asp Gly Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys           
                355                 360                 365               

ggc cct ccc gat gac cta ccc aat ggc cac gtg gac tat atc aca ggc       1155
Gly Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly           
            370                 375                 380                   

cct gaa gtg acc acc tac aaa gct gtg att cag tac agc tgt gaa gag       1203
Pro Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu           
        385                 390                 395                       

act ttc tac aca atg agc agc aat ggt aaa tat gtg tgt gag gct gat       1251
Thr Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp           
    400                 405                 410                           

gga ttc tgg acg agc tcc aaa gga gaa aaa tcc ctc ccg gtt tgc aag       1299
Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys           
415                 420                 425                 430           

cct gtc tgt gga ctg tcc aca cac act tca gga ggc cgt ata att gga       1347
Pro Val Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly           
                435                 440                 445               

gga cag cct gca aag cct ggt gac ttt cct tgg caa gtc ttg tta ctg       1395
Gly Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu           
            450                 455                 460                   

ggt gaa act aca gca gca ggt gct ctt ata cat gac gac tgg gtc cta       1443
Gly Glu Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu           
        465                 470                 475                       

aca gcg gct cat gct gta tat ggg aaa aca gag gcg atg tcc tcc ctg       1491
Thr Ala Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu           
    480                 485                 490                           

gac atc cgc atg ggc atc ctc aaa agg ctc tcc ctc att tac act caa       1539
Asp Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln           
495                 500                 505                 510           

gcc tgg cca gag gct gtc ttt atc cat gaa ggc tac act cac gga gct       1587
Ala Trp Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala           
                515                 520                 525               

ggt ttt gac aat gat ata gca ctg att aaa ctc aag aac aaa gtc aca       1635
Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr           
            530                 535                 540                   

atc aac aga aac atc atg ccg att tgt cta cca aga aaa gaa gct gca       1683
Ile Asn Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala           
        545                 550                 555                       

tcc tta atg aaa aca gac ttc gtt gga act gtg gct ggc tgg ggg tta       1731
Ser Leu Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu           
    560                 565                 570                           

acc cag aag ggg ttt ctt gct aga aac cta atg ttt gtg gac ata cca       1779
Thr Gln Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro           
575                 580                 585                 590           

att gtt gac cac caa aaa tgt gct act gcg tat aca aag cag ccc tac       1827
Ile Val Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr           
                595                 600                 605               

cca gga gca aaa gtg act gtt aac atg ctc tgt gct ggc cta gac cgc       1875
Pro Gly Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg           
            610                 615                 620                   

ggt ggc aag gac agc tgc aga ggt gac agc gga ggg gca tta gtg ttt       1923
Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe           
        625                 630                 635                       

cta gac aat gaa aca cag aga tgg ttt gtg gga gga ata gtt tcc tgg       1971
Leu Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp           
    640                 645                 650                           

ggt tct att aac tgt ggg ggg tca gaa cag tat ggg gtc tac acg aaa       2019
Gly Ser Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys           
655                 660                 665                 670           

gtc acg aac tat att ccc tgg att gag aac ata ata aat aat ttc taa       2067
Val Thr Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe               
                675                 680                 685               

tttgcaaaaa aaaaaaaaaa aaaa                                            2091


<210>  54
<211>  685
<212>  PRT
<213>  Rat

<400>  54

Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val Ser 
            20                  25                  30          


Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu Thr 
65                  70                  75                  80  


Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro Ser 
            100                 105                 110         


Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg Thr 
    130                 135                 140                 


Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr Leu 
145                 150                 155                 160 


Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln Asn 
                165                 170                 175     


Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly Arg 
            180                 185                 190         


Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile Thr 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala Gln 
225                 230                 235                 240 


Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser Asn 
            260                 265                 270         


Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro Thr 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu Gln 
                325                 330                 335     


Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro Glu 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe 
                405                 410                 415     


Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro Val 
            420                 425                 430         


Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly Gln 
        435                 440                 445             


Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly Glu 
    450                 455                 460                 


Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr Ala 
465                 470                 475                 480 


Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp Ile 
                485                 490                 495     


Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala Trp 
            500                 505                 510         


Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly Phe 
        515                 520                 525             


Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile Asn 
    530                 535                 540                 


Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser Leu 
545                 550                 555                 560 


Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr Gln 
                565                 570                 575     


Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile Val 
            580                 585                 590         


Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro Gly 
        595                 600                 605             


Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly Gly 
    610                 615                 620                 


Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp 
625                 630                 635                 640 


Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser 
                645                 650                 655     


Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val Thr 
            660                 665                 670         


Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
        675                 680                 685 


<210>  55
<211>  670
<212>  PRT
<213>  Rat

<400>  55

Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val 
1               5                   10                  15      


Ser Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Thr Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro 
                85                  90                  95      


Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg 
        115                 120                 125             


Thr Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr 
    130                 135                 140                 


Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln 
145                 150                 155                 160 


Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly 
                165                 170                 175     


Arg Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile 
        195                 200                 205             


Thr Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala 
    210                 215                 220                 


Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser 
                245                 250                 255     


Asn Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro 
        275                 280                 285             


Thr Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu 
305                 310                 315                 320 


Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro 
        355                 360                 365             


Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly 
385                 390                 395                 400 


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro 
                405                 410                 415     


Val Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly 
            420                 425                 430         


Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly 
        435                 440                 445             


Glu Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr 
    450                 455                 460                 


Ala Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp 
465                 470                 475                 480 


Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala 
                485                 490                 495     


Trp Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly 
            500                 505                 510         


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile 
        515                 520                 525             


Asn Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser 
    530                 535                 540                 


Leu Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr 
545                 550                 555                 560 


Gln Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile 
                565                 570                 575     


Val Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro 
            580                 585                 590         


Gly Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly 
        595                 600                 605             


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
    610                 615                 620                 


Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
625                 630                 635                 640 


Ser Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val 
                645                 650                 655     


Thr Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
            660                 665                 670 


<210>  56
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapiens

<400>  56
atgaggctgc tgaccctcct gggccttc                                          28


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapiens

<400>  57
gtgcccctcc tgcgtcacct ctg                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapiens

<400>  58
cagaggtgac gcaggagggg cac                                               23


<210>  59
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapiens

<400>  59
ttaaaatcac taattatgtt ctcgatc                                           27


<210>  60
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine

<400>  60
atgaggctac tcatcttcct gg                                                22


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine

<400>  61
ctgcagaggt gacgcagggg ggg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine

<400>  62
ccccccctgc gtcacctctg cag                                               23


<210>  63
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine

<400>  63
ttagaaatta cttattatgt tctcaatcc                                         29


<210>  64
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat

<400>  64
gaggtgacgc aggaggggca ttagtgttt                                         29


<210>  65
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat

<400>  65
ctagaaacac taatgcccct cctgcgtcac ctctgca                                37


<210>  66
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aggggtaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgagtga cgaaaaatcc      180

tacaggacat cgctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgacgtggag gaattgacta ctggggccag ggaaccctgg tcactgtctc ctca            354


<210>  67
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  68
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  69
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  70
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
tcctatgagc tgatacagcc accctcggtg tcagtggccc caggacagac ggccaccatt       60

acctgtgcgg gagacaacct tgggaagaaa cgtgtgcact ggtaccagca gaggccaggc      120

caggcccctg tgttggtcat ctatgatgat agcgaccggc cctcagggat ccctgaccga      180

ttctctgcct ccaactctgg gaacacggcc accctgacca tcactagggg cgaagccggg      240

gatgaggccg actattattg tcaggtgtgg gacattgcta ctgatcatgt ggtcttcggc      300

ggagggacca agctcaccgt ccta                                             324


<210>  71
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Ser Tyr Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ala Gly Asp Asn Leu Gly Lys Lys Arg Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Gly Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ala Thr Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly 
            100                 105                 110         


Ser Glu Gln Lys Leu Ile Ser Glu 
        115                 120 


<210>  72
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu 
            20                  25                  30          


Trp Cys Asn Gln 
        35      


<210>  73
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn Thr Cys Arg 
1               5                   10                  15      


Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu Trp Cys Asn 
            20                  25                  30          


Gln 
    


<210>  74
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu 
1               5                   10                  15      


Trp Cys Asn Gln 
            20  


<210>  75
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu 
            20                  25                  30          


Trp Cys Asn Gln Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser Gln Val 
        35                  40                  45              


Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu Thr Leu 
    50                  55                  60                  


Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly Lys Met 
65                  70                  75                  80  


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
                85                  90                  95      


Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser Leu Lys 
            100                 105                 110         


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
        115                 120                 125             


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
    130                 135                 140                 


Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
145                 150                 155                 160 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                165                 170                 175     


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
            180                 185                 190         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        195                 200                 205             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    210                 215                 220                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
225                 230                 235                 240 


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
                245                 250                 255     


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
385                 390                 395                 400 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                485                 490     


<210>  76
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ala Gly 
        435                 440                 445             


Gly Ser Gly Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp 
    450                 455                 460                 


Lys Cys Asn Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys 
465                 470                 475                 480 


Thr Lys Leu Trp Cys Asn Gln Gly Ser Gly Ala 
                485                 490     


<210>  77
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Leu Glu Val Thr Cys Glu Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn 
1               5                   10                  15      


Thr Cys Arg Cys Gly Ser Asp Gly Lys Ser Ala Val Cys Thr Lys Leu 
            20                  25                  30          


Trp Cys Asn Gln Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser Gln Pro 
        35                  40                  45              


Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln Thr Ala 
    50                  55                  60                  


Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala Tyr Trp 
65                  70                  75                  80  


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr Gln Asp 
                85                  90                  95      


Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
            100                 105                 110         


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu 
        115                 120                 125             


Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe Gly 
    130                 135                 140                 


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
145                 150                 155                 160 


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
                165                 170                 175     


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
            180                 185                 190         


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
        195                 200                 205             


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
    210                 215                 220                 


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
225                 230                 235                 240 


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
                245                 250                 255     


Cys Ser 
        


<210>  78
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser Ala Ala Gly Gly Ser Gly Leu Glu Val Thr Cys Glu 
    210                 215                 220                 


Pro Gly Thr Thr Phe Lys Asp Lys Cys Asn Thr Cys Arg Cys Gly Ser 
225                 230                 235                 240 


Asp Gly Lys Ser Ala Val Cys Thr Lys Leu Trp Cys Asn Gln Gly Ser 
                245                 250                 255     


Gly Ala 
        


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Gly Thr Gly Gly Gly Ser Gly Ser Ser Ser 
1               5                   10  


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Ala Ala Gly Gly Ser Gly 
1               5       


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Gly Ser Gly Ala 
1               


<210>  82
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggccttg       60

gaagtgacgt gtgagcccgg aacgacattc aaagacaagt gcaatacttg tcggtgcggt      120

tcagatggga aatcggcggt ctgcacaaag ctctggtgta accagggcac cggtggaggg      180

tcgggatcca gctcacaggt caccttgaag gagtctggtc ctgtgctggt gaaacccaca      240

gagaccctca cgctgacctg caccgtctct gggttctcac tcagcagggg taaaatgggt      300

gtgagctgga tccgtcagcc cccagggaag gccctggagt ggcttgcaca cattttttcg      360

agtgacgaaa aatcctacag gacatcgctg aagagcaggc tcaccatctc caaggacacc      420

tccaaaaacc aggtggtcct tacaatgacc aacatggacc ctgtggacac agccacgtat      480

tactgtgcac ggatacgacg tggaggaatt gactactggg gccagggaac cctggtcact      540

gtctcctcag cctccaccaa gggcccatcc gtcttccccc tggcgccctg ctccaggagc      600

acctccgaga gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      660

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      720

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      780

acgaagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga      840

gttgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt cctgggggga      900

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      960

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg     1020

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac     1080

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag     1140

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1200

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1260

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     1320

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1380

ctggactccg acggctcctt cttcctctac agcaggctaa ccgtggacaa gagcaggtgg     1440

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1500

cagaagagcc tctccctgtc tctcgggaaa tga                                  1533


<210>  83
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtcaccttga aggagtctgg tcctgtgctg gtgaaaccca cagagaccct cacgctgacc      120

tgcaccgtct ctgggttctc actcagcagg ggtaaaatgg gtgtgagctg gatccgtcag      180

cccccaggga aggccctgga gtggcttgca cacatttttt cgagtgacga aaaatcctac      240

aggacatcgc tgaagagcag gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc      300

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc acggatacga      360

cgtggaggaa ttgactactg gggccaggga accctggtca ctgtctcctc agcctccacc      420

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt      720

cccccatgcc caccatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc      780

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      840

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc     1020

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg     1380

tctctcggga aagccgctgg tggtagtggt ttggaagtga cgtgtgagcc cggaacgaca     1440

ttcaaagaca agtgcaatac ttgtcggtgc ggttcagatg ggaaatcggc ggtctgcaca     1500

aagctctggt gtaaccaggg tagtggtgct tga                                  1533


<210>  84
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggccttg       60

gaagtgacgt gtgagcccgg aacgacattc aaagacaagt gcaatacttg tcggtgcggt      120

tcagatggga aatcggcggt ctgcacaaag ctctggtgta accagggcac cggtggaggg      180

tcgggatcca gctcacagcc agtgctgact cagcccccct cactgtccgt gtccccagga      240

cagacagcca gcatcacctg ctctggagag aaattggggg ataaatatgc ttactggtat      300

cagcagaagc caggccagtc ccctgtgttg gtcatgtatc aagataaaca gcggccctca      360

gggatccctg agcgattctc tggctccaac tctgggaaca cagccactct gaccatcagc      420

gggacccagg ctatggatga ggctgactat tactgtcagg cgtgggacag cagcactgcg      480

gtattcggcg gagggaccaa gctgaccgtc ctaggccagc ctaaggcggc gccctcggtc      540

accctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      600

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      660

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      720

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      780

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            834


<210>  85
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

ccagtgctga ctcagccccc ctcactgtcc gtgtccccag gacagacagc cagcatcacc      120

tgctctggag agaaattggg ggataaatat gcttactggt atcagcagaa gccaggccag      180

tcccctgtgt tggtcatgta tcaagataaa cagcggccct cagggatccc tgagcgattc      240

tctggctcca actctgggaa cacagccact ctgaccatca gcgggaccca ggctatggat      300

gaggctgact attactgtca ggcgtgggac agcagcactg cggtattcgg cggagggacc      360

aagctgaccg tcctaggcca gcctaaggcg gcgccctcgg tcaccctgtt cccgccctcc      420

tctgaggagc ttcaagccaa caaggccaca ctggtgtgtc tcataagtga cttctacccg      480

ggagccgtga cagtggcctg gaaggcagat agcagccccg tcaaggcggg agtggagacc      540

accacaccct ccaaacaaag caacaacaag tacgcggcca gcagctatct gagcctgacg      600

cctgagcagt ggaagtccca cagaagctac agctgccagg tcacgcatga agggagcacc      660

gtggagaaga cagtggcccc tacagaatgt tcagccgctg gtggtagtgg tttggaagtg      720

acgtgtgagc ccggaacgac attcaaagac aagtgcaata cttgtcggtg cggttcagat      780

gggaaatcgg cggtctgcac aaagctctgg tgtaaccagg gtagtggtgc ttag            834


<210>  86
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  86

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  87
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Leu Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Asn Thr Tyr His Pro Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Asp Phe Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  88
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Ser Tyr Leu Met Ser 
1               5   


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Thr Ile Ser Gly Gly Gly Gly Asn Thr Tyr His Pro Asp Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

His Gly Asp Phe Gly Asn Tyr Phe Asp Tyr 
1               5                   10  


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Thr Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Lys Gln Ser Tyr Asn Leu Phe Thr 
1               5               


<210>  95
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
gaggtgaagc tggtggagtc tgggggaggc ttggtgaagc ctggagggtc cctaaaactc       60

tcctgtgcag cctcaggatt cactttcagt agttatctta tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtggtaa cacttaccat      180

ccagacagta tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccttgt attactgtgc aagacatggg      300

gactttggta actacttcga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  96
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcgggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtggaa cccaaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg      300

ttcacgttcg gtgctgggac caagctggag ctgaaacgg                             339


<210>  97
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Thr 
            20                  25                  30          


Tyr Trp Gly Val Thr Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  98
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


