                         SEQUENCE LISTING

<110>  Spartina Biotechnologies, LLC
 
<120>  TARGETED EXTRACELLULAR VESICLES FOR DELIVERY OF THERAPEUTICS

<130>  90355.00041

<150>  63/144,827
<151>  2021-02-02

<150>  63/184,011
<151>  2021-04-04

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA-nsp1

<400>  1
ggcattcagt acggtcgtat attggagata cgaccgtact gaatgcctt                   49


<210>  2
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA-GFP

<400>  2
atgaacttca gggtcagctt gcgttgaccc tgaagttcat tc                          42


<210>  3
<211>  1199
<212>  DNA
<213>  Artificial

<220>
<223>  Polymerase I-promoter  driven expression cassette

<400>  3
gcggccgccc gcttccgctt ccgcagtaaa aaatagtgag gaactgggtt agaattctat       60

gatccgggta aaaacatgta ttgtatatat ctattataat atacgatgag gatgatagtg      120

tgtaagagtg taccatttac taatgtatgt aagttactat ttactatttg gtctttttat      180

ttttcatttt tttttttttc gttgcaaaga tgggttgaaa gagaagggct ttcacaaagc      240

ttcccggggc acctgtcact ttggaaaaaa aatatacgct aagatttttg gagaatagct      300

taaattgaag tttttctcgg cgagaaatac gtagttaagg cagagcgaca gagagggcaa      360

aagaaaataa aagtaagatt ttagtttgta atgggagggg gggtttagtc atggagtaca      420

agtgtgagga aaagtagttg ggaggtactt catgcgaaag cagttgaaga caagttcaaa      480

acgggcgtgt ggcgtagttg gtagcgcgtt cccttagcat gggaaaggtc atgagttcga      540

ctcttatctc gtccaggcat tcagtacggt cgtatattgg agatacgacc gtactgaatg      600

ccttgcgcaa gtggtttagt ggtaaaatcc aacgttgcca tcgttgggcc cccggttcga      660

ttccgggctt gcgcaatgaa cttcagggtc agcttgcgtt gaccctgaag ttcattcgcg      720

caagtggttt agtggtaaaa tccaacgttg ccatcgttgg gcccccggtt cgattccggg      780

cttgcgcatt ttatttcttt ctaagtgggt actggcagga gccggggcct agtttagaga      840

gaagtagact gaacaagtct ctataaattt tatttgtctt aagaattcta tgatccgggt      900

aaaaacatgt attgtatata tctattataa tatacgatga ggatgatagt gtgtaagagt      960

gtaccattta ctaatgtatg taagttacta tttactattt ggtcttttta tttttcattt     1020

tttttttttt cgttgcaaag atgggttgaa agagaagggc tttcacaaag cttcccgagc     1080

gtgaaaggat ttgcccggac agtttgcttc atggagcagt tttttccgca ccatcagagc     1140

ggcaaacatg agtgcttgta taagtttaga gaattgagaa aagctcattt cttaattaa      1199


<210>  4
<211>  746
<212>  DNA
<213>  Saccharomyces

<400>  4
ggccaaggca aaaagattcc ttgattacgt aagggagtta gaatcatttt gaataaaaaa       60

cacgcttttt cagttcgagt ttatcattat caatactgcc atttcaaaga atacgtaaat      120

aattaatagt agtgattttc ctaactttat ttagtcaaaa aattagcctt ttaattctgc      180

tgtaacccgt acatgcccaa aatagggggc gggttacaca gaatatataa catcgtaggt      240

gtctgggtga acagtttatt cctggcatcc actaaatata atggagcccg ctttttaagc      300

tggcatccag aaaaaaaaag aatcccagca ccaaaatatt gttttcttca ccaaccatca      360

gttcataggt ccattctctt agcgcaacta cagagaacag gggcacaaac aggcaaaaaa      420

cgggcacaac ctcaatggag tgatgcaacc tgcctggagt aaatgatgac acaaggcaat      480

tgacccacgc atgtatctat ctcattttct tacaccttct attaccttct gctctctctg      540

atttggaaaa agctgaaaaa aaaggttgaa accagttccc tgaaattatt cccctacttg      600

actaataagt atataaagac ggtaggtatt gattgtaatt ctgtaaatct atttcttaaa      660

cttcttaaat tctactttta tagttagtct tttttttagt tttaaaacac caagaactta      720

gtttcgaata aacacacata aacaaa                                           746


<210>  5
<211>  325
<212>  DNA
<213>  Saccharomyces

<400>  5
acaggcccct tttcctttgt cgatatcatg taattagtta tgtcacgctt acattcacgc       60

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc      120

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt      180

cttttttttc tgtacaaacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag      240

aaggttttgg gacaagctta cgtctcacgg atcgtatatg ccgtagcgac aatctaagaa      300

ctatgcgagg acacgctagc agctg                                            325


<210>  6
<211>  1392
<212>  DNA
<213>  Artificial

<220>
<223>  Polymerase II-promoter driven expression cassette

<400>  6
ggccaaggca aaaagattcc ttgattacgt aagggagtta gaatcatttt gaataaaaaa       60

cacgcttttt cagttcgagt ttatcattat caatactgcc atttcaaaga atacgtaaat      120

aattaatagt agtgattttc ctaactttat ttagtcaaaa aattagcctt ttaattctgc      180

tgtaacccgt acatgcccaa aatagggggc gggttacaca gaatatataa catcgtaggt      240

gtctgggtga acagtttatt cctggcatcc actaaatata atggagcccg ctttttaagc      300

tggcatccag aaaaaaaaag aatcccagca ccaaaatatt gttttcttca ccaaccatca      360

gttcataggt ccattctctt agcgcaacta cagagaacag gggcacaaac aggcaaaaaa      420

cgggcacaac ctcaatggag tgatgcaacc tgcctggagt aaatgatgac acaaggcaat      480

tgacccacgc atgtatctat ctcattttct tacaccttct attaccttct gctctctctg      540

atttggaaaa agctgaaaaa aaaggttgaa accagttccc tgaaattatt cccctacttg      600

actaataagt atataaagac ggtaggtatt gattgtaatt ctgtaaatct atttcttaaa      660

cttcttaaat tctactttta tagttagtct tttttttagt tttaaaacac caagaactta      720

gtttcgaata aacacacata aacaaaaaac aaagagctca aaacgggcgt gtggcgtagt      780

tggtagcgcg ttcccttagc atgggaaagg tcatgagttc gactcttatc tcgtccaggc      840

attcagtacg gtcgtatatt ggagatacga ccgtactgaa tgccttgcgc aagtggttta      900

gtggtaaaat ccaacgttgc catcgttggg cccccggttc gattccgggc ttgcgcaatg      960

aacttcaggg tcagcttgcg ttgaccctga agttcattcg gccggcatgg tcccagcctc     1020

ctcgctggcg ccggctgggc aacatgcttc ggcatggcga atgggacaca ggcccctttt     1080

cctttgtcga tatcatgtaa ttagttatgt cacgcttaca ttcacgccct ccccccacat     1140

ccgctctaac cgaaaaggaa ggagttagac aacctgaagt ctaggtccct atttattttt     1200

ttatagttat gttagtatta agaacgttat ttatatttca aatttttctt ttttttctgt     1260

acaaacgcgt gtacgcatgt aacattatac tgaaaacctt gcttgagaag gttttgggac     1320

aagcttacgt ctcacggatc gtatatgccg tagcgacaat ctaagaacta tgcgaggaca     1380

cgctagcagc tg                                                         1392


<210>  7
<211>  493
<212>  DNA
<213>  Artificial

<220>
<223>  5' homological sequence for genome integration at chromosome XVI

<400>  7
tgtgcagcat attgtcctct agatgcaaac tctgcaggtc catttgcagt aaagtgagtt       60

gcctctcgaa gaatcattaa tttcgtataa ccgtcactat taaagtcaga aaataaattc      120

tgtcgtagac aatgttacca taatgttctt gtccattttg catacacttt aaatattcat      180

ttgatttctc agggttcatg atcataataa attgcgcatt cgcaaggcgg tagtattata      240

atggggtcca tcattctgta gcaagaagtt acagtacgct gttcaagcgt taaacaagat      300

aagtaatctc gaatgaaaca ttcatatttc gcatgagcca acatacagtt gctgagtaat      360

cttcattgcg cttatttatc ggcattgaga ttgtaaagga agtaaaacgc atttttgcag      420

atctgttctc ttatgtattt ttaatcgtcc ttgtatggaa gtatcaaagg ggacgttctt      480

cacctccttg gaa                                                         493


<210>  8
<211>  453
<212>  DNA
<213>  Artificial

<220>
<223>  3' homological sequence for genome integration at chromosome XVI

<400>  8
gcgactagat tgtaaatcat tctttattta atctctttct ttaactactg cttaaagtat       60

aatttggtcc gtagtttaat aactatacta agcgtaacaa tgcatactga cattataagc      120

ctgaacatta cgagtttaag ttgtatgtag gcgttctgta agaggttact gcgtaaatta      180

tcaacgaatg cattggtgta tttgcgaaag ctacttcttt taacaagtat ttacataaga      240

ataatggtga tctgctcaac tgatttggtg ataactctaa cttttttagc aacaatttaa      300

aagataattc gaacatatat aacagtagga agaatttgtg tacgtcaaat taagataatt      360

tagcattacc aaagttatta acctaaacat aaaatatata tgagacacat gtggaaatcg      420

tatgaaacaa ctgttatgaa actgacaaga atg                                   453


<210>  9
<211>  3618
<212>  DNA
<213>  Artificial

<220>
<223>  Full sequence of polymerase I-based integration insert

<400>  9
tgtgcagcat attgtcctct agatgcaaac tctgcaggtc catttgcagt aaagtgagtt       60

gcctctcgaa gaatcattaa tttcgtataa ccgtcactat taaagtcaga aaataaattc      120

tgtcgtagac aatgttacca taatgttctt gtccattttg catacacttt aaatattcat      180

ttgatttctc agggttcatg atcataataa attgcgcatt cgcaaggcgg tagtattata      240

atggggtcca tcattctgta gcaagaagtt acagtacgct gttcaagcgt taaacaagat      300

aagtaatctc gaatgaaaca ttcatatttc gcatgagcca acatacagtt gctgagtaat      360

cttcattgcg cttatttatc ggcattgaga ttgtaaagga agtaaaacgc atttttgcag      420

atctgttctc ttatgtattt ttaatcgtcc ttgtatggaa gtatcaaagg ggacgttctt      480

cacctccttg gaataggtct agagatctgt ttagcttgcc tcgtccccgc cgggtcaccc      540

ggccagcgac atggaggccc agaataccct ccttgacagt cttgacgtgc gcagctcagg      600

ggcatgatgt gactgtcgcc cgtacattta gcccatacat ccccatgtat aatcatttgc      660

atccatacat tttgatggcc gcacggcgcg aagcaaaaat tacggctcct cgctgcagac      720

ctgcgagcag ggaaacgctc ccctcacaga cgcgttgaat tgtccccacg ccgcgcccct      780

gtagagaaat ataaaaggtt aggatttgcc actgaggttc ttctttcata tacttccttt      840

taaaatcttg ctaggataca gttctcacat cacatccgaa cataaacaac catgggtaag      900

gaaaagactc acgtttcgag gccgcgatta aattccaaca tggatgctga tttatatggg      960

tataaatggg ctcgcgataa tgtcgggcaa tcaggtgcga caatctatcg attgtatggg     1020

aagcccgatg cgccagagtt gtttctgaaa catggcaaag gtagcgttgc caatgatgtt     1080

acagatgaga tggtcagact aaactggctg acggaattta tgcctcttcc gaccatcaag     1140

cattttatcc gtactcctga tgatgcatgg ttactcacca ctgcgatccc cggcaaaaca     1200

gcattccagg tattagaaga atatcctgat tcaggtgaaa atattgttga tgcgctggca     1260

gtgttcctgc gccggttgca ttcgattcct gtttgtaatt gtccttttaa cagcgatcgc     1320

gtatttcgtc tcgctcaggc gcaatcacga atgaataacg gtttggttga tgcgagtgat     1380

tttgatgacg agcgtaatgg ctggcctgtt gaacaagtct ggaaagaaat gcataagctt     1440

ttgccattct caccggattc agtcgtcact catggtgatt tctcacttga taaccttatt     1500

tttgacgagg ggaaattaat aggttgtatt gatgttggac gagtcggaat cgcagaccga     1560

taccaggatc ttgccatcct atggaactgc ctcggtgagt tttctccttc attacagaaa     1620

cggctttttc aaaaatatgg tattgataat cctgatatga ataaattgca gtttcatttg     1680

atgctcgatg agtttttcta atcagtactg acaataaaaa gattcttgtt ttcaagaact     1740

tgtcatttgt atagtttttt tatattgtag ttgttctatt ttaatcaaat gttagcgtga     1800

tttatatttt ttttcgcctc gacatcatct gcccagatgc gaagttaagt gcgcagaaag     1860

taatatcatg cgtcaatcgt atgtgaatgc tggtcgctat actgctgtcg attcgatact     1920

aacgccgcca tccagtgtcg aaaacgagct ctcgagaacc cttaatgcgg ccgcccgctt     1980

ccgcttccgc agtaaaaaat agtgaggaac tgggttagaa ttctatgatc cgggtaaaaa     2040

catgtattgt atatatctat tataatatac gatgaggatg atagtgtgta agagtgtacc     2100

atttactaat gtatgtaagt tactatttac tatttggtct ttttattttt catttttttt     2160

tttttcgttg caaagatggg ttgaaagaga agggctttca caaagcttcc cggggcacct     2220

gtcactttgg aaaaaaaata tacgctaaga tttttggaga atagcttaaa ttgaagtttt     2280

tctcggcgag aaatacgtag ttaaggcaga gcgacagaga gggcaaaaga aaataaaagt     2340

aagattttag tttgtaatgg gagggggggt ttagtcatgg agtacaagtg tgaggaaaag     2400

tagttgggag gtacttcatg cgaaagcagt tgaagacaag ttcaaaacgg gcgtgtggcg     2460

tagttggtag cgcgttccct tagcatggga aaggtcatga gttcgactct tatctcgtcc     2520

aggcattcag tacggtcgta tattggagat acgaccgtac tgaatgcctt gcgcaagtgg     2580

tttagtggta aaatccaacg ttgccatcgt tgggcccccg gttcgattcc gggcttgcgc     2640

aatgaacttc agggtcagct tgcgttgacc ctgaagttca ttcgcgcaag tggtttagtg     2700

gtaaaatcca acgttgccat cgttgggccc ccggttcgat tccgggcttg cgcattttat     2760

ttctttctaa gtgggtactg gcaggagccg gggcctagtt tagagagaag tagactgaac     2820

aagtctctat aaattttatt tgtcttaaga attctatgat ccgggtaaaa acatgtattg     2880

tatatatcta ttataatata cgatgaggat gatagtgtgt aagagtgtac catttactaa     2940

tgtatgtaag ttactattta ctatttggtc tttttatttt tcattttttt ttttttcgtt     3000

gcaaagatgg gttgaaagag aagggctttc acaaagcttc ccgagcgtga aaggatttgc     3060

ccggacagtt tgcttcatgg agcagttttt tccgcaccat cagagcggca aacatgagtg     3120

cttgtataag tttagagaat tgagaaaagc tcatttctta attaagcgac tagattgtaa     3180

atcattcttt atttaatctc tttctttaac tactgcttaa agtataattt ggtccgtagt     3240

ttaataacta tactaagcgt aacaatgcat actgacatta taagcctgaa cattacgagt     3300

ttaagttgta tgtaggcgtt ctgtaagagg ttactgcgta aattatcaac gaatgcattg     3360

gtgtatttgc gaaagctact tcttttaaca agtatttaca taagaataat ggtgatctgc     3420

tcaactgatt tggtgataac tctaactttt ttagcaacaa tttaaaagat aattcgaaca     3480

tatataacag taggaagaat ttgtgtacgt caaattaaga taatttagca ttaccaaagt     3540

tattaaccta aacataaaat atatatgaga cacatgtgga aatcgtatga aacaactgtt     3600

atgaaactga caagaatg                                                   3618


<210>  10
<211>  3879
<212>  DNA
<213>  Artificial

<220>
<223>  Full sequence of polymerase II-based integration insert

<400>  10
tgtgcagcat attgtcctct agatgcaaac tctgcaggtc catttgcagt aaagtgagtt       60

gcctctcgaa gaatcattaa tttcgtataa ccgtcactat taaagtcaga aaataaattc      120

tgtcgtagac aatgttacca taatgttctt gtccattttg catacacttt aaatattcat      180

ttgatttctc agggttcatg atcataataa attgcgcatt cgcaaggcgg tagtattata      240

atggggtcca tcattctgta gcaagaagtt acagtacgct gttcaagcgt taaacaagat      300

aagtaatctc gaatgaaaca ttcatatttc gcatgagcca acatacagtt gctgagtaat      360

cttcattgcg cttatttatc ggcattgaga ttgtaaagga agtaaaacgc atttttgcag      420

atctgttctc ttatgtattt ttaatcgtcc ttgtatggaa gtatcaaagg ggacgttctt      480

cacctccttg gaataggtct agagatctgt ttagcttgcc tcgtccccgc cgggtcaccc      540

ggccagcgac atggaggccc agaataccct ccttgacagt cttgacgtgc gcagctcagg      600

ggcatgatgt gactgtcgcc cgtacattta gcccatacat ccccatgtat aatcatttgc      660

atccatacat tttgatggcc gcacggcgcg aagcaaaaat tacggctcct cgctgcagac      720

ctgcgagcag ggaaacgctc ccctcacaga cgcgttgaat tgtccccacg ccgcgcccct      780

gtagagaaat ataaaaggtt aggatttgcc actgaggttc ttctttcata tacttccttt      840

taaaatcttg ctaggataca gttctcacat cacatccgaa cataaacaac catgggtaag      900

gaaaagactc acgtttcgag gccgcgatta aattccaaca tggatgctga tttatatggg      960

tataaatggg ctcgcgataa tgtcgggcaa tcaggtgcga caatctatcg attgtatggg     1020

aagcccgatg cgccagagtt gtttctgaaa catggcaaag gtagcgttgc caatgatgtt     1080

acagatgaga tggtcagact aaactggctg acggaattta tgcctcttcc gaccatcaag     1140

cattttatcc gtactcctga tgatgcatgg ttactcacca ctgcgatccc cggcaaaaca     1200

gcattccagg tattagaaga atatcctgat tcaggtgaaa atattgttga tgcgctggca     1260

gtgttcctgc gccggttgca ttcgattcct gtttgtaatt gtccttttaa cagcgatcgc     1320

gtatttcgtc tcgctcaggc gcaatcacga atgaataacg gtttggttga tgcgagtgat     1380

tttgatgacg agcgtaatgg ctggcctgtt gaacaagtct ggaaagaaat gcataagctt     1440

ttgccattct caccggattc agtcgtcact catggtgatt tctcacttga taaccttatt     1500

tttgacgagg ggaaattaat aggttgtatt gatgttggac gagtcggaat cgcagaccga     1560

taccaggatc ttgccatcct atggaactgc ctcggtgagt tttctccttc attacagaaa     1620

cggctttttc aaaaatatgg tattgataat cctgatatga ataaattgca gtttcatttg     1680

atgctcgatg agtttttcta atcagtactg acaataaaaa gattcttgtt ttcaagaact     1740

tgtcatttgt atagtttttt tatattgtag ttgttctatt ttaatcaaat gttagcgtga     1800

tttatatttt ttttcgcctc gacatcatct gcccagatgc gaagttaagt gcgcagaaag     1860

taatatcatg cgtcaatcgt atgtgaatgc tggtcgctat actgctgtcg attcgatact     1920

aacgccgcca tccagtgtcg aaaacgagct ctcgagaacc cttaatcgag tgtagccaga     1980

tctcaatgct acatcatcga aaaagtctag aggccaaggc aaaaagattc cttgattacg     2040

taagggagtt agaatcattt tgaataaaaa acacgctttt tcagttcgag tttatcatta     2100

tcaatactgc catttcaaag aatacgtaaa taattaatag tagtgatttt cctaacttta     2160

tttagtcaaa aaattagcct tttaattctg ctgtaacccg tacatgccca aaataggggg     2220

cgggttacac agaatatata acatcgtagg tgtctgggtg aacagtttat tcctggcatc     2280

cactaaatat aatggagccc gctttttaag ctggcatcca gaaaaaaaaa gaatcccagc     2340

accaaaatat tgttttcttc accaaccatc agttcatagg tccattctct tagcgcaact     2400

acagagaaca ggggcacaaa caggcaaaaa acgggcacaa cctcaatgga gtgatgcaac     2460

ctgcctggag taaatgatga cacaaggcaa ttgacccacg catgtatcta tctcattttc     2520

ttacaccttc tattaccttc tgctctctct gatttggaaa aagctgaaaa aaaaggttga     2580

aaccagttcc ctgaaattat tcccctactt gactaataag tatataaaga cggtaggtat     2640

tgattgtaat tctgtaaatc tatttcttaa acttcttaaa ttctactttt atagttagtc     2700

ttttttttag ttttaaaaca ccaagaactt agtttcgaat aaacacacat aaacaaaaaa     2760

caaagagctc aaaacgggcg tgtggcgtag ttggtagcgc gttcccttag catgggaaag     2820

gtcatgagtt cgactcttat ctcgtccagg cattcagtac ggtcgtatat tggagatacg     2880

accgtactga atgccttgcg caagtggttt agtggtaaaa tccaacgttg ccatcgttgg     2940

gcccccggtt cgattccggg cttgcgcaat gaacttcagg gtcagcttgc gttgaccctg     3000

aagttcattc ggccggcatg gtcccagcct cctcgctggc gccggctggg caacatgctt     3060

cggcatggcg aatgggacac aggccccttt tcctttgtcg atatcatgta attagttatg     3120

tcacgcttac attcacgccc tccccccaca tccgctctaa ccgaaaagga aggagttaga     3180

caacctgaag tctaggtccc tatttatttt tttatagtta tgttagtatt aagaacgtta     3240

tttatatttc aaatttttct tttttttctg tacaaacgcg tgtacgcatg taacattata     3300

ctgaaaacct tgcttgagaa ggttttggga caagcttacg tctcacggat cgtatatgcc     3360

gtagcgacaa tctaagaact atgcgaggac acgctagcag ctggtggtat tggcccatct     3420

ctatcggcga ctagattgta aatcattctt tatttaatct ctttctttaa ctactgctta     3480

aagtataatt tggtccgtag tttaataact atactaagcg taacaatgca tactgacatt     3540

ataagcctga acattacgag tttaagttgt atgtaggcgt tctgtaagag gttactgcgt     3600

aaattatcaa cgaatgcatt ggtgtatttg cgaaagctac ttcttttaac aagtatttac     3660

ataagaataa tggtgatctg ctcaactgat ttggtgataa ctctaacttt tttagcaaca     3720

atttaaaaga taattcgaac atatataaca gtaggaagaa tttgtgtacg tcaaattaag     3780

ataatttagc attaccaaag ttattaacct aaacataaaa tatatatgag acacatgtgg     3840

aaatcgtatg aaacaactgt tatgaaactg acaagaatg                            3879


<210>  11
<211>  661
<212>  DNA
<213>  Sars-CoV-2

<400>  11
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct       60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact      120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc      180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt      240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac      300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg      360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg      420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa      480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact      540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg      600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag ctcgagtcta gaggaagcgg      660

a                                                                      661


<210>  12
<211>  714
<212>  DNA
<213>  Aequorea victoria

<400>  12
atgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc       60

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      120

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      180

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag      240

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      300

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      360

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag      420

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc      480

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac      540

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac      600

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg      660

ctggagttcg tgaccgccgc cgggatcact cacggcatgg acgagctgta caag            714


<210>  13
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  Nsp1-GFP fusion construct

<400>  13
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct       60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact      120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc      180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt      240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac      300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg      360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg      420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa      480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact      540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg      600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag ctcgagtcta gaggaagcgg      660

agctactaac ttcagcctgc tgaagcaggc tggagacgtg gaggagaacc ctggacctat      720

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga      780

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa      840

gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt      900

gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca      960

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa     1020

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa     1080

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct     1140

ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat     1200

caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca     1260

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct     1320

gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct     1380

ggagttcgtg accgccgccg ggatcactca cggcatggac gagctgtaca agta           1434


<210>  14
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  ACE2 Inhibitor - 1

<400>  14

Gly Asp Tyr Ser His Cys Ser Pro Leu Arg Tyr Tyr Pro Trp Trp Lys 
1               5                   10                  15      


Cys Thr Tyr Pro Asp Pro Glu Gly Gly Gly 
            20                  25      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  ACE2 Inhibitor - 2

<400>  15

Gly Asp Asp Asp Asp Cys Gly Trp Ile Gly Phe Ala Asn Phe His Leu 
1               5                   10                  15      


Cys Leu His Gly Asp Pro Glu Gly Gly Gly 
            20                  25      


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker peptide

<400>  16

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  17
<211>  42
<212>  RNA
<213>  Artificial

<220>
<223>  SiRNA targeting GFP

<400>  17
augaacuuca gggucagcuu gcguugaccc ugaaguucau uc                          42


<210>  18
<211>  49
<212>  RNA
<213>  Artificial

<220>
<223>  SiRNA targeting nsp1 Sars-CoV2 gene

<400>  18
ggcauucagu acggucguau auuggagaua cgaccguacu gaaugccuu                   49


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Nsp1 Northern Blot probe

<400>  19
aggcattcag tacggtcgta                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  qNsp1-5' probe

<400>  20
cgtacgtggc tttggagact                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  qNsp1-3' probe

<400>  21
accatgaggt gcagttcgag                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  qGen-5' probe

<400>  22
tgctcgacgt tgtcactgaa                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  qGen-3' probe

<400>  23
gatgtttcgc ttggtggtcg                                                   20


<210>  24
<211>  282
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Ser Asp Arg Glu Gln Ser Ser Gly Asn Thr Ala Phe Glu Asn Pro 
1               5                   10                  15      


Lys Ala Leu Asp Ser Ser Glu Gly Glu Phe Ile Ser Glu Asn Asn Asp 
            20                  25                  30          


Gln Ser Arg His Ser Gln Glu Ser Ile Cys Lys Ile Tyr Thr Ala Gly 
        35                  40                  45              


Lys Asn Asn Glu Tyr Ile Tyr Ile Gly Arg Gln Lys Phe Leu Arg Asp 
    50                  55                  60                  


Asp Leu Phe Glu Ala Phe Gly Gly Thr Leu Asn Pro Gly Leu Ala Pro 
65                  70                  75                  80  


Ala Pro Val His Lys Phe Ala Asn Pro Ala Pro Leu Gly Leu Ser Gly 
                85                  90                  95      


Phe Ala Leu Thr Thr Phe Val Leu Ser Met Phe Asn Ala Arg Ala Gln 
            100                 105                 110         


Gly Ile Thr Ile Pro Asn Val Val Val Gly Cys Ala Met Phe Tyr Gly 
        115                 120                 125             


Gly Leu Val Gln Leu Ile Ala Gly Ile Trp Glu Ile Ala Leu Glu Asn 
    130                 135                 140                 


Thr Phe Gly Gly Thr Ala Leu Cys Ser Phe Gly Gly Phe Trp Leu Ser 
145                 150                 155                 160 


Phe Gly Ala Ile Tyr Ile Pro Trp Phe Gly Ile Leu Asp Ala Tyr Lys 
                165                 170                 175     


Asp Lys Glu Ser Asp Leu Gly Asn Ala Leu Gly Phe Tyr Leu Leu Gly 
            180                 185                 190         


Trp Ala Leu Phe Thr Phe Gly Leu Ser Val Cys Thr Met Lys Ser Thr 
        195                 200                 205             


Ile Met Phe Phe Ala Leu Phe Phe Leu Leu Ala Val Thr Phe Leu Leu 
    210                 215                 220                 


Leu Ser Ile Ala Asn Phe Thr Gly Glu Val Gly Val Thr Arg Ala Gly 
225                 230                 235                 240 


Gly Val Leu Gly Val Ile Val Ala Phe Ile Ala Trp Tyr Asn Ala Tyr 
                245                 250                 255     


Ala Gly Ile Ala Thr Arg Gln Asn Ser Tyr Ile Met Val His Pro Phe 
            260                 265                 270         


Ala Leu Pro Ser Asn Asp Lys Val Phe Phe 
        275                 280         


<210>  25
<211>  263
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Arg Asn Phe Phe Thr Leu Phe Phe Ala Ala Ile Phe Ser Leu Gly 
1               5                   10                  15      


Ala Leu Ile Leu Ala Ile Val Ala Cys Ala Gly Ser Thr Lys Asn Tyr 
            20                  25                  30          


Ser Pro Ile Asn Lys Ile Tyr Cys Ala Glu Leu Asp Leu Ser Gln Met 
        35                  40                  45              


Lys Val Ser Thr Val Leu Pro Ser Leu Ser Ser Ala Thr Leu Ser Ser 
    50                  55                  60                  


Leu Gly Leu Pro Ser Tyr Ile Asn Ile Gly Leu Trp Ser Tyr Cys Thr 
65                  70                  75                  80  


Val Asp Ser Ser His Asn Ile Gln Ser Cys Ser Ser Pro His Gly Ile 
                85                  90                  95      


Gln Asn Phe Asn Leu Ser Ser Leu Val Tyr Asp Asn Ile Asn Asn Asn 
            100                 105                 110         


Glu Ala Leu Glu Leu Met Asp Ser Val Ala Ser Val Val Leu Pro Glu 
        115                 120                 125             


Lys Leu Lys Ser Lys Met Thr Tyr Tyr Asn Asn Leu Val Lys Cys Met 
    130                 135                 140                 


Phe Ile Thr Ile Leu Ile Gly Ile Val Leu Thr Phe Val Asn Leu Val 
145                 150                 155                 160 


Phe Asn Val Leu Arg Trp Ile Ile His Ile Arg Pro Leu Thr Trp Phe 
                165                 170                 175     


Gly Ala Phe Phe Ser Phe Phe Ala Phe Ala Ala Leu Leu Val Ser Ile 
            180                 185                 190         


Gly Ser Cys Leu Gly Thr Tyr Ser Tyr Ile Lys Tyr Ile Leu Lys His 
        195                 200                 205             


Asn Tyr Ser Asp Tyr Gly Ile Ser Met Ser Ile Gly Arg Asn Tyr Gln 
    210                 215                 220                 


Gly Leu Met Trp Gly Ala Val Val Gly Ala Leu Leu Asn Phe Ile Leu 
225                 230                 235                 240 


Trp Cys Ser Val Arg Ser Arg Pro Thr Val Ile Tyr Ala Asn Ala Pro 
                245                 250                 255     


Ile Glu Glu Lys Pro Leu Ile 
            260             


<210>  26
<211>  448
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Met Leu Ser Leu Lys Thr Leu Leu Cys Thr Leu Leu Thr Val Ser Ser 
1               5                   10                  15      


Val Leu Ala Thr Pro Val Pro Ala Arg Asp Pro Ser Ser Ile Gln Phe 
            20                  25                  30          


Val His Glu Glu Asn Lys Lys Arg Tyr Tyr Asp Tyr Asp His Gly Ser 
        35                  40                  45              


Leu Gly Glu Pro Ile Arg Gly Val Asn Ile Gly Gly Trp Leu Leu Leu 
    50                  55                  60                  


Glu Pro Tyr Ile Thr Pro Ser Leu Phe Glu Ala Phe Arg Thr Asn Asp 
65                  70                  75                  80  


Asp Asn Asp Glu Gly Ile Pro Val Asp Glu Tyr His Phe Cys Gln Tyr 
                85                  90                  95      


Leu Gly Lys Asp Leu Ala Lys Ser Arg Leu Gln Ser His Trp Ser Thr 
            100                 105                 110         


Phe Tyr Gln Glu Gln Asp Phe Ala Asn Ile Ala Ser Gln Gly Phe Asn 
        115                 120                 125             


Leu Val Arg Ile Pro Ile Gly Tyr Trp Ala Phe Gln Thr Leu Asp Asp 
    130                 135                 140                 


Asp Pro Tyr Val Ser Gly Leu Gln Glu Ser Tyr Leu Asp Gln Ala Ile 
145                 150                 155                 160 


Gly Trp Ala Arg Asn Asn Ser Leu Lys Val Trp Val Asp Leu His Gly 
                165                 170                 175     


Ala Ala Gly Ser Gln Asn Gly Phe Asp Asn Ser Gly Leu Arg Asp Ser 
            180                 185                 190         


Tyr Lys Phe Leu Glu Asp Ser Asn Leu Ala Val Thr Thr Asn Val Leu 
        195                 200                 205             


Asn Tyr Ile Leu Lys Lys Tyr Ser Ala Glu Glu Tyr Leu Asp Thr Val 
    210                 215                 220                 


Ile Gly Ile Glu Leu Ile Asn Glu Pro Leu Gly Pro Val Leu Asp Met 
225                 230                 235                 240 


Asp Lys Met Lys Asn Asp Tyr Leu Ala Pro Ala Tyr Glu Tyr Leu Arg 
                245                 250                 255     


Asn Asn Ile Lys Ser Asp Gln Val Ile Ile Ile His Asp Ala Phe Gln 
            260                 265                 270         


Pro Tyr Asn Tyr Trp Asp Asp Phe Met Thr Glu Asn Asp Gly Tyr Trp 
        275                 280                 285             


Gly Val Thr Ile Asp His His His Tyr Gln Val Phe Ala Ser Asp Gln 
    290                 295                 300                 


Leu Glu Arg Ser Ile Asp Glu His Ile Lys Val Ala Cys Glu Trp Gly 
305                 310                 315                 320 


Thr Gly Val Leu Asn Glu Ser His Trp Thr Val Cys Gly Glu Phe Ala 
                325                 330                 335     


Ala Ala Leu Thr Asp Cys Thr Lys Trp Leu Asn Ser Val Gly Phe Gly 
            340                 345                 350         


Ala Arg Tyr Asp Gly Ser Trp Val Asn Gly Asp Gln Thr Ser Ser Tyr 
        355                 360                 365             


Ile Gly Ser Cys Ala Asn Asn Asp Asp Ile Ala Tyr Trp Ser Asp Glu 
    370                 375                 380                 


Arg Lys Glu Asn Thr Arg Arg Tyr Val Glu Ala Gln Leu Asp Ala Phe 
385                 390                 395                 400 


Glu Met Arg Gly Gly Trp Ile Ile Trp Cys Tyr Lys Thr Glu Ser Ser 
                405                 410                 415     


Leu Glu Trp Asp Ala Gln Arg Leu Met Phe Asn Gly Leu Phe Pro Gln 
            420                 425                 430         


Pro Leu Thr Asp Arg Lys Tyr Pro Asn Gln Cys Gly Thr Ile Ser Asn 
        435                 440                 445             


<210>  27
<211>  313
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  27

Met Arg Phe Ser Thr Thr Leu Ala Thr Ala Ala Thr Ala Leu Phe Phe 
1               5                   10                  15      


Thr Ala Ser Gln Val Ser Ala Ile Gly Glu Leu Ala Phe Asn Leu Gly 
            20                  25                  30          


Val Lys Asn Asn Asp Gly Thr Cys Lys Ser Thr Ser Asp Tyr Glu Thr 
        35                  40                  45              


Glu Leu Gln Ala Leu Lys Ser Tyr Thr Ser Thr Val Lys Val Tyr Ala 
    50                  55                  60                  


Ala Ser Asp Cys Asn Thr Leu Gln Asn Leu Gly Pro Ala Ala Glu Ala 
65                  70                  75                  80  


Glu Gly Phe Thr Ile Phe Val Gly Val Trp Pro Thr Asp Asp Ser His 
                85                  90                  95      


Tyr Ala Ala Glu Lys Ala Ala Leu Gln Thr Tyr Leu Pro Lys Ile Lys 
            100                 105                 110         


Glu Ser Thr Val Ala Gly Phe Leu Val Gly Ser Glu Ala Leu Tyr Arg 
        115                 120                 125             


Asn Asp Leu Thr Ala Ser Gln Leu Ser Asp Lys Ile Asn Asp Val Arg 
    130                 135                 140                 


Ser Val Val Ala Asp Ile Ser Asp Ser Asp Gly Lys Ser Tyr Ser Gly 
145                 150                 155                 160 


Lys Gln Val Gly Thr Val Asp Ser Trp Asn Val Leu Val Ala Gly Tyr 
                165                 170                 175     


Asn Ser Ala Val Ile Glu Ala Ser Asp Phe Val Met Ala Asn Ala Phe 
            180                 185                 190         


Ser Tyr Trp Gln Gly Gln Thr Met Gln Asn Ala Ser Tyr Ser Phe Phe 
        195                 200                 205             


Asp Asp Ile Met Gln Ala Leu Gln Val Ile Gln Ser Thr Lys Gly Ser 
    210                 215                 220                 


Thr Asp Ile Thr Phe Trp Val Gly Glu Thr Gly Trp Pro Thr Asp Gly 
225                 230                 235                 240 


Thr Asn Phe Glu Ser Ser Tyr Pro Ser Val Asp Asn Ala Lys Gln Phe 
                245                 250                 255     


Trp Lys Glu Gly Ile Cys Ser Met Arg Ala Trp Gly Val Asn Val Ile 
            260                 265                 270         


Val Phe Glu Ala Phe Asp Glu Asp Trp Lys Pro Asn Thr Ser Gly Thr 
        275                 280                 285             


Ser Asp Val Glu Lys His Trp Gly Val Phe Thr Ser Ser Asp Asn Leu 
    290                 295                 300                 


Lys Tyr Ser Leu Asp Cys Asp Phe Ser 
305                 310             


<210>  28
<211>  559
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  28

Met Leu Phe Lys Ser Leu Ser Lys Leu Ala Thr Ala Ala Ala Phe Phe 
1               5                   10                  15      


Ala Gly Val Ala Thr Ala Asp Asp Val Pro Ala Ile Glu Val Val Gly 
            20                  25                  30          


Asn Lys Phe Phe Tyr Ser Asn Asn Gly Ser Gln Phe Tyr Ile Arg Gly 
        35                  40                  45              


Val Ala Tyr Gln Ala Asp Thr Ala Asn Glu Thr Ser Gly Ser Thr Val 
    50                  55                  60                  


Asn Asp Pro Leu Ala Asn Tyr Glu Ser Cys Ser Arg Asp Ile Pro Tyr 
65                  70                  75                  80  


Leu Lys Lys Leu Asn Thr Asn Val Ile Arg Val Tyr Ala Ile Asn Thr 
                85                  90                  95      


Thr Leu Asp His Ser Glu Cys Met Lys Ala Leu Asn Asp Ala Asp Ile 
            100                 105                 110         


Tyr Val Ile Ala Asp Leu Ala Ala Pro Ala Thr Ser Ile Asn Arg Asp 
        115                 120                 125             


Asp Pro Thr Trp Thr Val Asp Leu Phe Asn Ser Tyr Lys Thr Val Val 
    130                 135                 140                 


Asp Thr Phe Ala Asn Tyr Thr Asn Val Leu Gly Phe Phe Ala Gly Asn 
145                 150                 155                 160 


Glu Val Thr Asn Asn Tyr Thr Asn Thr Asp Ala Ser Ala Phe Val Lys 
                165                 170                 175     


Ala Ala Ile Arg Asp Val Arg Gln Tyr Ile Ser Asp Lys Asn Tyr Arg 
            180                 185                 190         


Lys Ile Pro Val Gly Tyr Ser Ser Asn Asp Asp Glu Asp Thr Arg Val 
        195                 200                 205             


Lys Met Thr Asp Tyr Phe Ala Cys Gly Asp Asp Asp Val Lys Ala Asp 
    210                 215                 220                 


Phe Tyr Gly Ile Asn Met Tyr Glu Trp Cys Gly Lys Ser Asp Phe Lys 
225                 230                 235                 240 


Thr Ser Gly Tyr Ala Asp Arg Thr Ala Glu Phe Lys Asn Leu Ser Ile 
                245                 250                 255     


Pro Val Phe Phe Ser Glu Tyr Gly Cys Asn Glu Val Thr Pro Arg Leu 
            260                 265                 270         


Phe Thr Glu Val Glu Ala Leu Tyr Gly Ser Asn Met Thr Asp Val Trp 
        275                 280                 285             


Ser Gly Gly Ile Val Tyr Met Tyr Phe Glu Glu Thr Asn Lys Tyr Gly 
    290                 295                 300                 


Leu Val Ser Ile Asp Gly Asn Asp Val Lys Thr Leu Asp Asp Phe Asn 
305                 310                 315                 320 


Asn Tyr Ser Ser Glu Ile Asn Lys Ile Ser Pro Thr Ser Ala Asn Thr 
                325                 330                 335     


Lys Ser Tyr Ser Ala Thr Thr Ser Asp Val Ala Cys Pro Ala Thr Gly 
            340                 345                 350         


Lys Tyr Trp Ser Ala Ala Thr Glu Leu Pro Pro Thr Pro Asn Gly Gly 
        355                 360                 365             


Leu Cys Ser Cys Met Asn Ala Ala Asn Ser Cys Val Val Ser Asp Asp 
    370                 375                 380                 


Val Asp Ser Asp Asp Tyr Glu Thr Leu Phe Asn Trp Ile Cys Asn Glu 
385                 390                 395                 400 


Val Asp Cys Ser Gly Ile Ser Ala Asn Gly Thr Ala Gly Lys Tyr Gly 
                405                 410                 415     


Ala Tyr Ser Phe Cys Thr Pro Lys Glu Gln Leu Ser Phe Val Met Asn 
            420                 425                 430         


Leu Tyr Tyr Glu Lys Ser Gly Gly Ser Lys Ser Asp Cys Ser Phe Ser 
        435                 440                 445             


Gly Ser Ala Thr Leu Gln Thr Ala Thr Thr Gln Ala Ser Cys Ser Ser 
    450                 455                 460                 


Ala Leu Lys Glu Ile Gly Ser Met Gly Thr Asn Ser Ala Ser Gly Ser 
465                 470                 475                 480 


Val Asp Leu Gly Ser Gly Thr Glu Ser Ser Thr Ala Ser Ser Asn Ala 
                485                 490                 495     


Ser Gly Ser Ser Ser Lys Ser Asn Ser Gly Ser Ser Gly Ser Ser Ser 
            500                 505                 510         


Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ser Ser Ser Lys Lys Asn 
        515                 520                 525             


Ala Ala Thr Asn Val Lys Ala Asn Leu Ala Gln Val Val Phe Thr Ser 
    530                 535                 540                 


Ile Ile Ser Leu Ser Ile Ala Ala Gly Val Gly Phe Ala Leu Val 
545                 550                 555                 


<210>  29
<211>  375
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  29

Met Ile Phe Asn Pro Val Ile Ser Asn His Lys Leu Ser His Tyr Ile 
1               5                   10                  15      


His Val Phe Cys Thr Phe Thr Thr Phe Cys Ile Leu Gly Thr Glu Thr 
            20                  25                  30          


Arg Gln Ala Ile Thr Ala Leu Ser Thr Tyr Thr Pro Ala Phe Val Thr 
        35                  40                  45              


Ala Pro Thr Val Leu Trp Ser Asn Cys Ser Ser Cys Met Leu Met Gly 
    50                  55                  60                  


Ile Met Gln Ser Leu Asn Ala Tyr Thr Trp Met Lys Asp His Gln Val 
65                  70                  75                  80  


Leu Phe Leu Gly Val Thr Thr Gly Tyr Cys Gly Ala Leu Ser Ser Phe 
                85                  90                  95      


Ser Ser Met Leu Leu Glu Met Phe Glu His Ser Thr Asn Leu Thr Asn 
            100                 105                 110         


Gly Asn Ile Ala Asn His Thr Lys Leu Pro Asn Arg Ala Tyr Gly Ile 
        115                 120                 125             


Met Glu Phe Leu Ser Val Leu Leu Val His Leu Met Val Ser Met Gly 
    130                 135                 140                 


Ser Leu Ile Phe Gly Arg Gln Leu Gly Lys Glu Val Ile Val Ala Tyr 
145                 150                 155                 160 


Gly Ser Ser Ser Phe Ser Lys Pro Tyr Thr Pro Pro Ser Asp Thr Val 
                165                 170                 175     


Lys Glu Asn Ala Gly Asp Val Asp Thr Gln Glu Met Glu Lys Asn Ile 
            180                 185                 190         


Leu Glu Phe Lys Phe Lys Thr Pro Ala Pro Phe Phe Lys Lys Phe Phe 
        195                 200                 205             


Asp Ile Val Asp Lys Leu Ala Tyr Ala Leu Ala Phe Pro Leu Ile Ile 
    210                 215                 220                 


Leu Phe Val Val Leu Cys Ala Tyr Tyr Glu Asn Tyr Ser Arg Gly Lys 
225                 230                 235                 240 


Trp Thr Leu Pro Cys Leu Phe Gly Ile Phe Ala Gly Phe Leu Arg Tyr 
                245                 250                 255     


Trp Leu Ala Glu Met Phe Asn Lys Thr Asn Lys Lys Phe Pro Leu Gly 
            260                 265                 270         


Thr Phe Leu Ala Asn Val Phe Ala Thr Leu Leu Ile Gly Ile Phe Thr 
        275                 280                 285             


Met Val Gln Arg Gly Lys Lys His Phe Ser Thr Asp Val Pro Ile Val 
    290                 295                 300                 


Asn Ser Leu Asn Ser Cys His Ile Val Ser Ala Leu Ile Ser Gly Phe 
305                 310                 315                 320 


Cys Gly Thr Leu Ser Thr Ile Ser Thr Phe Ile Asn Glu Gly Tyr Lys 
                325                 330                 335     


Leu Ser Phe Ile Asn Met Leu Ile Tyr Tyr Thr Val Ser Ile Ala Ile 
            340                 345                 350         


Ser Tyr Cys Leu Leu Val Ile Thr Leu Gly Ser Tyr Ala Trp Thr Arg 
        355                 360                 365             


Gly Leu Thr Asn Pro Ile Cys 
    370                 375 


<210>  30
<211>  636
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  30

Met Thr Asn Ala Leu Leu Ser Ile Ala Val Leu Leu Phe Ser Met Leu 
1               5                   10                  15      


Ser Leu Ala Gln Ala Glu Thr His Thr Phe Asn Trp Thr Thr Gly Trp 
            20                  25                  30          


Asp Tyr Arg Asn Val Asp Gly Leu Lys Ser Arg Pro Val Ile Thr Cys 
        35                  40                  45              


Asn Gly Gln Phe Pro Trp Pro Asp Ile Thr Val Asn Lys Gly Asp Arg 
    50                  55                  60                  


Val Gln Ile Tyr Leu Thr Asn Gly Met Asn Asn Thr Asn Thr Ser Met 
65                  70                  75                  80  


His Phe His Gly Leu Phe Gln Asn Gly Thr Ala Ser Met Asp Gly Val 
                85                  90                  95      


Pro Phe Leu Thr Gln Cys Pro Ile Ala Pro Gly Ser Thr Met Leu Tyr 
            100                 105                 110         


Asn Phe Thr Val Asp Tyr Asn Val Gly Thr Tyr Trp Tyr His Ser His 
        115                 120                 125             


Thr Asp Gly Gln Tyr Glu Asp Gly Met Lys Gly Leu Phe Ile Ile Lys 
    130                 135                 140                 


Asp Asp Ser Phe Pro Tyr Asp Tyr Asp Glu Glu Leu Ser Leu Ser Leu 
145                 150                 155                 160 


Ser Glu Trp Tyr His Asp Leu Val Thr Asp Leu Thr Lys Ser Phe Met 
                165                 170                 175     


Ser Val Tyr Asn Pro Thr Gly Ala Glu Pro Ile Pro Gln Asn Leu Ile 
            180                 185                 190         


Val Asn Asn Thr Met Asn Leu Thr Trp Glu Val Gln Pro Asp Thr Thr 
        195                 200                 205             


Tyr Leu Leu Arg Ile Val Asn Val Gly Gly Phe Val Ser Gln Tyr Phe 
    210                 215                 220                 


Trp Ile Glu Asp His Glu Met Thr Val Val Glu Ile Asp Gly Ile Thr 
225                 230                 235                 240 


Thr Glu Lys Asn Val Thr Asp Met Leu Tyr Ile Thr Val Ala Gln Arg 
                245                 250                 255     


Tyr Thr Val Leu Val His Thr Lys Asn Asp Thr Asp Lys Asn Phe Ala 
            260                 265                 270         


Ile Met Gln Lys Phe Asp Asp Thr Met Leu Asp Val Ile Pro Ser Asp 
        275                 280                 285             


Leu Gln Leu Asn Ala Thr Ser Tyr Met Val Tyr Asn Lys Thr Ala Ala 
    290                 295                 300                 


Leu Pro Thr Gln Asn Tyr Val Asp Ser Ile Asp Asn Phe Leu Asp Asp 
305                 310                 315                 320 


Phe Tyr Leu Gln Pro Tyr Glu Lys Glu Ala Ile Tyr Gly Glu Pro Asp 
                325                 330                 335     


His Val Ile Thr Val Asp Val Val Met Asp Asn Leu Lys Asn Gly Val 
            340                 345                 350         


Asn Tyr Ala Phe Phe Asn Asn Ile Thr Tyr Thr Ala Pro Lys Val Pro 
        355                 360                 365             


Thr Leu Met Thr Val Leu Ser Ser Gly Asp Gln Ala Asn Asn Ser Glu 
    370                 375                 380                 


Ile Tyr Gly Ser Asn Thr His Thr Phe Ile Leu Glu Lys Asp Glu Ile 
385                 390                 395                 400 


Val Glu Ile Val Leu Asn Asn Gln Asp Thr Gly Thr His Pro Phe His 
                405                 410                 415     


Leu His Gly His Ala Phe Gln Thr Ile Gln Arg Asp Arg Thr Tyr Asp 
            420                 425                 430         


Asp Ala Leu Gly Glu Val Pro His Ser Phe Asp Pro Asp Asn His Pro 
        435                 440                 445             


Ala Phe Pro Glu Tyr Pro Met Arg Arg Asp Thr Leu Tyr Val Arg Pro 
    450                 455                 460                 


Gln Ser Asn Phe Val Ile Arg Phe Lys Ala Asp Asn Pro Gly Val Trp 
465                 470                 475                 480 


Phe Phe His Cys His Ile Glu Trp His Leu Leu Gln Gly Leu Gly Leu 
                485                 490                 495     


Val Leu Val Glu Asp Pro Phe Gly Ile Gln Asp Ala His Ser Gln Gln 
            500                 505                 510         


Leu Ser Glu Asn His Leu Glu Val Cys Gln Ser Cys Ser Val Ala Thr 
        515                 520                 525             


Glu Gly Asn Ala Ala Ala Asn Thr Leu Asp Leu Thr Asp Leu Thr Gly 
    530                 535                 540                 


Glu Asn Val Gln His Ala Phe Ile Pro Thr Gly Phe Thr Lys Lys Gly 
545                 550                 555                 560 


Ile Ile Ala Met Thr Phe Ser Cys Phe Ala Gly Ile Leu Gly Ile Ile 
                565                 570                 575     


Thr Ile Ala Ile Tyr Gly Met Met Asp Met Glu Asp Ala Thr Glu Lys 
            580                 585                 590         


Val Ile Arg Asp Leu His Val Asp Pro Glu Val Leu Leu Asn Glu Val 
        595                 600                 605             


Asp Glu Asn Glu Glu Arg Gln Val Asn Glu Asp Arg His Ser Thr Glu 
    610                 615                 620                 


Lys His Gln Phe Leu Thr Lys Ala Lys Arg Phe Phe 
625                 630                 635     


<210>  31
<211>  507
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  31

Met Lys Val Leu Asp Leu Leu Thr Val Leu Ser Ala Ser Ser Leu Leu 
1               5                   10                  15      


Ser Thr Phe Ala Ala Ala Glu Ser Thr Ala Thr Ala Asp Ser Thr Thr 
            20                  25                  30          


Ala Ala Ser Ser Thr Ala Ser Cys Asn Pro Leu Lys Thr Thr Gly Cys 
        35                  40                  45              


Thr Pro Asp Thr Ala Leu Ala Thr Ser Phe Ser Glu Asp Phe Ser Ser 
    50                  55                  60                  


Ser Ser Lys Trp Phe Thr Asp Leu Lys His Ala Gly Glu Ile Lys Tyr 
65                  70                  75                  80  


Gly Ser Asp Gly Leu Ser Met Thr Leu Ala Lys Arg Tyr Asp Asn Pro 
                85                  90                  95      


Ser Leu Lys Ser Asn Phe Tyr Ile Met Tyr Gly Lys Leu Glu Val Ile 
            100                 105                 110         


Leu Lys Ala Ala Asn Gly Thr Gly Ile Val Ser Ser Phe Tyr Leu Gln 
        115                 120                 125             


Ser Asp Asp Leu Asp Glu Ile Asp Ile Glu Trp Val Gly Gly Asp Asn 
    130                 135                 140                 


Thr Gln Phe Gln Ser Asn Phe Phe Ser Lys Gly Asp Thr Thr Thr Tyr 
145                 150                 155                 160 


Asp Arg Gly Glu Phe His Gly Val Asp Thr Pro Thr Asp Lys Phe His 
                165                 170                 175     


Asn Tyr Thr Leu Asp Trp Ala Met Asp Lys Thr Thr Trp Tyr Leu Asp 
            180                 185                 190         


Gly Glu Ser Val Arg Val Leu Ser Asn Thr Ser Ser Glu Gly Tyr Pro 
        195                 200                 205             


Gln Ser Pro Met Tyr Leu Met Met Gly Ile Trp Ala Gly Gly Asp Pro 
    210                 215                 220                 


Asp Asn Ala Ala Gly Thr Ile Glu Trp Ala Gly Gly Glu Thr Asn Tyr 
225                 230                 235                 240 


Asn Asp Ala Pro Phe Thr Met Tyr Ile Glu Lys Val Ile Val Thr Asp 
                245                 250                 255     


Tyr Ser Thr Gly Lys Lys Tyr Thr Tyr Gly Asp Gln Ser Gly Ser Trp 
            260                 265                 270         


Glu Ser Ile Glu Ala Asp Gly Gly Ser Ile Tyr Gly Arg Tyr Asp Gln 
        275                 280                 285             


Ala Gln Glu Asp Phe Ala Val Leu Ala Asn Gly Gly Ser Ile Ser Ser 
    290                 295                 300                 


Ser Ser Thr Ser Ser Ser Thr Val Ser Ser Ser Ala Ser Ser Thr Val 
305                 310                 315                 320 


Ser Ser Ser Val Ser Ser Thr Val Ser Ser Ser Ala Ser Ser Thr Val 
                325                 330                 335     


Ser Ser Ser Val Ser Ser Thr Val Ser Ser Ser Ser Ser Val Ser Ser 
            340                 345                 350         


Ser Ser Ser Thr Ser Pro Ser Ser Ser Thr Ala Thr Ser Ser Lys Thr 
        355                 360                 365             


Leu Ala Ser Ser Ser Val Thr Thr Ser Ser Ser Ile Ser Ser Phe Glu 
    370                 375                 380                 


Lys Gln Ser Ser Ser Ser Ser Lys Lys Thr Val Ala Ser Ser Ser Thr 
385                 390                 395                 400 


Ser Glu Ser Ile Ile Ser Ser Thr Lys Thr Pro Ala Thr Val Ser Ser 
                405                 410                 415     


Thr Thr Arg Ser Thr Val Ala Pro Thr Thr Gln Gln Ser Ser Val Ser 
            420                 425                 430         


Ser Asp Ser Pro Val Gln Asp Lys Gly Gly Val Ala Thr Ser Ser Asn 
        435                 440                 445             


Asp Val Thr Ser Ser Thr Thr Gln Ile Ser Ser Lys Tyr Thr Ser Thr 
    450                 455                 460                 


Ile Gln Ser Ser Ser Ser Glu Ala Ser Ser Thr Asn Ser Val Gln Ile 
465                 470                 475                 480 


Ser Asn Gly Ala Asp Leu Ala Gln Ser Leu Pro Arg Glu Gly Lys Leu 
                485                 490                 495     


Phe Ser Val Leu Val Ala Leu Leu Ala Leu Leu 
            500                 505         


<210>  32
<211>  53
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  32

Met Val Gln Tyr Ala Pro Phe Leu Leu Gly Lys Phe Ser Asp Pro Leu 
1               5                   10                  15      


Leu Ala Ile Met Val Gly Cys Leu Ser Tyr Tyr Val Tyr Glu Arg Lys 
            20                  25                  30          


Met Gly Arg Pro Gln Gly His His Leu His Glu Leu Ile Lys Lys Arg 
        35                  40                  45              


Trp Asp Asp Arg Lys 
    50              


<210>  33
<211>  302
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Val Lys Val Trp Asn Ile Val Leu Arg Leu Val Val Leu Leu Phe 
1               5                   10                  15      


Leu Ala Gly Asn Thr Leu Leu Leu Ile Leu Met Ile Ile Ser Gly Ala 
            20                  25                  30          


Thr Asp His Tyr Pro Val Asn Arg Phe Tyr Trp Val Gln Gly Asn Thr 
        35                  40                  45              


Thr Gly Ile Pro Asn Ala Gly Asp Glu Thr Arg Trp Thr Phe Trp Gly 
    50                  55                  60                  


Ala Cys Leu Gln Asp Lys Asp Gly Ser Asp Thr Cys Thr Ser Asn Leu 
65                  70                  75                  80  


Ala Pro Ala Tyr Pro Ile Ser Pro Val Asp Asn Phe Asn Thr His Ile 
                85                  90                  95      


Asn Val Pro His Gln Phe Ile Ser Lys Arg Asp Ala Phe Tyr Tyr Leu 
            100                 105                 110         


Thr Arg Phe Ser Phe Cys Phe Phe Trp Ile Ala Leu Ala Phe Val Gly 
        115                 120                 125             


Val Ser Phe Ile Leu Tyr Val Leu Thr Trp Cys Ser Lys Met Leu Ser 
    130                 135                 140                 


Glu Met Val Leu Ile Leu Met Ser Phe Gly Phe Val Phe Asn Thr Ala 
145                 150                 155                 160 


Ala Val Val Leu Gln Thr Ala Ala Ser Ala Met Ala Lys Asn Ala Phe 
                165                 170                 175     


His Asp Asp His Arg Ser Ala Gln Leu Gly Ala Ser Met Met Gly Met 
            180                 185                 190         


Ala Trp Ala Ser Val Phe Leu Cys Ile Val Glu Phe Ile Leu Leu Val 
        195                 200                 205             


Phe Trp Ser Val Arg Ala Arg Leu Ala Ser Thr Tyr Ser Ile Asp Asn 
    210                 215                 220                 


Ser Arg Tyr Arg Thr Ser Ser Arg Trp Asn Pro Phe His Arg Glu Lys 
225                 230                 235                 240 


Glu Gln Ala Thr Asp Pro Ile Leu Thr Ala Thr Gly Pro Glu Asp Met 
                245                 250                 255     


Gln Gln Ser Ala Ser Ile Val Gly Pro Ser Ser Asn Ala Asn Pro Val 
            260                 265                 270         


Thr Ala Thr Ala Ala Thr Glu Asn Gln Pro Lys Gly Ile Asn Phe Phe 
        275                 280                 285             


Thr Ile Arg Lys Ser His Glu Arg Pro Asp Asp Val Ser Val 
    290                 295                 300         


<210>  34
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  35
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  36
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210>  37
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Leu Asn Ser Gly Ser Pro Pro Ala Ile Gly Pro Tyr Tyr Glu 
1               5                   10                  15      


Asn His Gly Tyr Gln Pro Glu Asn Pro Tyr Pro Ala Gln Pro Thr Val 
            20                  25                  30          


Val Pro Thr Val Tyr Glu Val His Pro Ala Gln Tyr Tyr Pro Ser Pro 
        35                  40                  45              


Val Pro Gln Tyr Ala Pro Arg Val Leu Thr Gln Ala Ser Asn Pro Val 
    50                  55                  60                  


Val Cys Thr Gln Pro Lys Ser Pro Ser Gly Thr Val Cys Thr Ser Lys 
65                  70                  75                  80  


Thr Lys Lys Ala Leu Cys Ile Thr Leu Thr Leu Gly Thr Phe Leu Val 
                85                  90                  95      


Gly Ala Ala Leu Ala Ala Gly Leu Leu Trp Lys Phe Met Gly Ser Lys 
            100                 105                 110         


Cys Ser Asn Ser Gly Ile Glu Cys Asp Ser Ser Gly Thr Cys Ile Asn 
        115                 120                 125             


Pro Ser Asn Trp Cys Asp Gly Val Ser His Cys Pro Gly Gly Glu Asp 
    130                 135                 140                 


Glu Asn Arg Cys Val Arg Leu Tyr Gly Pro Asn Phe Ile Leu Gln Val 
145                 150                 155                 160 


Tyr Ser Ser Gln Arg Lys Ser Trp His Pro Val Cys Gln Asp Asp Trp 
                165                 170                 175     


Asn Glu Asn Tyr Gly Arg Ala Ala Cys Arg Asp Met Gly Tyr Lys Asn 
            180                 185                 190         


Asn Phe Tyr Ser Ser Gln Gly Ile Val Asp Asp Ser Gly Ser Thr Ser 
        195                 200                 205             


Phe Met Lys Leu Asn Thr Ser Ala Gly Asn Val Asp Ile Tyr Lys Lys 
    210                 215                 220                 


Leu Tyr His Ser Asp Ala Cys Ser Ser Lys Ala Val Val Ser Leu Arg 
225                 230                 235                 240 


Cys Ile Ala Cys Gly Val Asn Leu Asn Ser Ser Arg Gln Ser Arg Ile 
                245                 250                 255     


Val Gly Gly Glu Ser Ala Leu Pro Gly Ala Trp Pro Trp Gln Val Ser 
            260                 265                 270         


Leu His Val Gln Asn Val His Val Cys Gly Gly Ser Ile Ile Thr Pro 
        275                 280                 285             


Glu Trp Ile Val Thr Ala Ala His Cys Val Glu Lys Pro Leu Asn Asn 
    290                 295                 300                 


Pro Trp His Trp Thr Ala Phe Ala Gly Ile Leu Arg Gln Ser Phe Met 
305                 310                 315                 320 


Phe Tyr Gly Ala Gly Tyr Gln Val Glu Lys Val Ile Ser His Pro Asn 
                325                 330                 335     


Tyr Asp Ser Lys Thr Lys Asn Asn Asp Ile Ala Leu Met Lys Leu Gln 
            340                 345                 350         


Lys Pro Leu Thr Phe Asn Asp Leu Val Lys Pro Val Cys Leu Pro Asn 
        355                 360                 365             


Pro Gly Met Met Leu Gln Pro Glu Gln Leu Cys Trp Ile Ser Gly Trp 
    370                 375                 380                 


Gly Ala Thr Glu Glu Lys Gly Lys Thr Ser Glu Val Leu Asn Ala Ala 
385                 390                 395                 400 


Lys Val Leu Leu Ile Glu Thr Gln Arg Cys Asn Ser Arg Tyr Val Tyr 
                405                 410                 415     


Asp Asn Leu Ile Thr Pro Ala Met Ile Cys Ala Gly Phe Leu Gln Gly 
            420                 425                 430         


Asn Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Thr Ser 
        435                 440                 445             


Lys Asn Asn Ile Trp Trp Leu Ile Gly Asp Thr Ser Trp Gly Ser Gly 
    450                 455                 460                 


Cys Ala Lys Ala Tyr Arg Pro Gly Val Tyr Gly Asn Val Met Val Phe 
465                 470                 475                 480 


Thr Asp Trp Ile Tyr Arg Gln Met Arg Ala Asp Gly 
                485                 490         


