                         SEQUENCE LISTING

<110>  THE CLEVELAND CLINIC FOUNDATION
 
<120>  TREATMENT OF CVD AND SYSTEMIC SCLEROSIS WITH BETA-1 ADRENERGIC 
       RECEPTOR ANTIBODIES

<130>  CCF-39230.601

<150>  US 63/144,735
<151>  2021-02-02

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      


Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          


Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              


Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  


Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  


Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      


Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         


Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             


Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 


Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 


Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     


Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         


Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             


Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 


Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 


Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     


Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         


Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             


Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 


Arg Ala Gly Lys Arg Arg Ala Leu Ala Pro Arg Gly Pro Ala Arg Ala 
305                 310                 315                 320 


Glu Gly Ala Gln Asp Ala Gly His His His Gly Arg Leu His Ala Leu 
                325                 330                 335     


Leu Ala Ala Leu Leu Pro Gly Gln Arg Gly Glu Gly Leu Pro Pro Arg 
            340                 345                 350         


Ala Gly Ala Arg Pro Pro Leu Arg Leu Leu Gln Leu Ala Gly Leu Arg 
        355                 360                 365             


Gln Leu Gly Leu Gln Pro His His Leu Leu Pro Gln Pro Arg Leu Pro 
    370                 375                 380                 


Gln Gly Leu Pro Ala Thr Ala Leu Leu Arg Ala Gln Gly Cys Pro Pro 
385                 390                 395                 400 


Ala Pro Arg Asp Pro Arg Arg Pro Ala Ala Arg Leu Gly Leu Ser Gly 
                405                 410                 415     


Pro Ala Arg Thr Pro Ala Ile Ala Arg Gly Arg Leu Gly Arg Arg Arg 
            420                 425                 430         


Arg Arg Cys Arg Arg Gly His Ala Ala Arg Ala Pro Ala Gly Ala Leu 
        435                 440                 445             


Gly Arg Leu Gln Arg Arg Gly Gly Gly Gly Gln Arg Leu Glu Pro Gly 
    450                 455                 460                 


Arg Ala Val Pro Pro Arg Leu Arg Leu Gly Ile Gln Gly Val Gly Pro 
465                 470                 475                 480 


Gly Ala Gly Arg Gly Leu Arg Ala Arg Leu Pro Arg Gly Thr Arg Arg 
                485                 490                 495     


Ser Val Phe Thr 
            500 


<210>  2
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  2

His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg Cys Tyr Asn Asp 
1               5                   10                  15      


Pro Lys Cys Cys Asp Phe Val Thr Asn Arg 
            20                  25      


<210>  3
<211>  1503
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggcgcgg gggtgctcgt cctgggcgcc tccgagcccg gtaacctgtc gtcggccgca       60

ccgctccccg acggcgcggc caccgcggcg cggctgctgg tgcccgcgtc gccgcccgcc      120

tcgttgctgc ctcccgccag cgaaagcccc gagccgctgt ctcagcagtg gacagcgggc      180

atgggtctgc tgatggcgct catcgtgctg ctcatcgtgg cgggcaatgt gctggtgatc      240

gtggccatcg ccaagacgcc gcggctgcag acgctcacca acctcttcat catgtccctg      300

gccagcgccg acctggtcat ggggctgctg gtggtgccgt tcggggccac catcgtggtg      360

tggggccgct gggagtacgg ctccttcttc tgcgagctgt ggacctcagt ggacgtgctg      420

tgcgtgacgg ccagcatcga gaccctgtgt gtcattgccc tggaccgcta cctcgccatc      480

acctcgccct tccgctacca gagcctgctg acgcgcgcgc gggcgcgggg cctcgtgtgc      540

accgtgtggg ccatctcggc cctggtgtcc ttcctgccca tcctcatgca ctggtggcgg      600

gcggagagcg acgaggcgcg ccgctgctac aacgacccca agtgctgcga cttcgtcacc      660

aaccgggcct acgccatcgc ctcgtccgta gtctccttct acgtgcccct gtgcatcatg      720

gccttcgtgt acctgcgggt gttccgcgag gcccagaagc aggtgaagaa gatcgacagc      780

tgcgagcgcc gtttcctcgg cggcccagcg cggccgccct cgccctcgcc ctcgcccgtc      840

cccgcgcccg cgccgccgcc cggacccccg cgccccgccg ccgccgccgc caccgccccg      900

ctggccaacg ggcgtgcggg taagcggcgg gccctcgcgc ctcgtggccc tgcgcgagca      960

gaaggcgctc aggacgctgg gcatcatcat gggcgtcttc acgctctgct ggctgccctt     1020

cttcctggcc aacgtggtga aggccttcca ccgcgagctg gtgcccgacc gcctcttcgt     1080

cttcttcaac tggctgggct acgccaactc ggccttcaac cccatcatct actgccgcag     1140

ccccgacttc cgcaaggcct tccagcgact gctctgctgc gcgcgcaggg ctgcccgccg     1200

gcgccacgcg acccacggag accggccgcg cgcctcgggc tgtctggccc ggcccggacc     1260

cccgccatcg cccggggccg cctcggacga cgacgacgac gatgtcgtcg gggccacgcc     1320

gcccgcgcgc ctgctggagc cctgggccgg ctgcaacggc ggggcggcgg cggacagcga     1380

ctcgagcctg gacgagccgt gccgccccgg cttcgcctcg gaatccaagg tgtagggccc     1440

ggcgcggggc gcggactccg ggcacggctt cccaggggaa cgaggagatc tgtgtttact     1500

taa                                                                   1503


