                         SEQUENCE LISTING

<110>  BIORCHESTRA CO., LTD.
 
<120>  USE OF MIRNA-485 INHIBITOR TO REGULATE PSD95, SYNAPTOPHYSIN, AND 
       CASPASE-3 EXPRESSION

<130>  4366.042PC01

<150>  US 63/146,513
<151>  2021-02-05

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  1
gucauacacg gcucuccucu cu                                                22


<210>  2
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  2
uguauga                                                                  7


<210>  3
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  3
guguauga                                                                 8


<210>  4
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  4
cguguauga                                                                9


<210>  5
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  5
ccguguauga                                                              10


<210>  6
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  6
gccguguaug a                                                            11


<210>  7
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  7
agccguguau ga                                                           12


<210>  8
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  8
gagccgugua uga                                                          13


<210>  9
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  9
agagccgugu auga                                                         14


<210>  10
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  10
gagagccgug uauga                                                        15


<210>  11
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  11
ggagagccgu guauga                                                       16


<210>  12
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  12
aggagagccg uguauga                                                      17


<210>  13
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  13
gaggagagcc guguauga                                                     18


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  14
agaggagagc cguguauga                                                    19


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  15
gagaggagag ccguguauga                                                   20


<210>  16
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  16
uguaugac                                                                 8


<210>  17
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  17
guguaugac                                                                9


<210>  18
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  18
cguguaugac                                                              10


<210>  19
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  19
ccguguauga c                                                            11


<210>  20
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  20
gccguguaug ac                                                           12


<210>  21
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  21
agccguguau gac                                                          13


<210>  22
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  22
gagccgugua ugac                                                         14


<210>  23
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  23
agagccgugu augac                                                        15


<210>  24
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  24
gagagccgug uaugac                                                       16


<210>  25
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  25
ggagagccgu guaugac                                                      17


<210>  26
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  26
aggagagccg uguaugac                                                     18


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  27
gaggagagcc guguaugac                                                    19


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  28
agaggagagc cguguaugac                                                   20


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  29
gagaggagag ccguguauga c                                                 21


<210>  30
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  30
agagaggaga gccguguaug ac                                                22


<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  33
agaggcuggc cgugaugaau uc                                                22


<210>  34
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  34
agucauacac ggcucuccuc uc                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  35
agaggcuggc cgugaugaau uc                                                22


<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  49
ucauaca                                                                  7


<210>  50
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  50
gaggcug                                                                  7


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  51
cgaggtcgac ttcctaga                                                     18


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  52
catacacggc tctcctctct aaa                                               23


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  53
tcctgtggca tccatgaaac                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  54
caatgcctgg gtacatggtg                                                   20


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  55
ccaagtggag gagcagct                                                     18


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  56
gacaaggtac aacccatcgg                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  57
ttcgacacat gggataacga gg                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  58
tttttgctgt gagtcccgga g                                                 21


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  59
cagcctagca gcacgtaaat                                                   20


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  60
gaatcgagca ccagttacg                                                    19


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  61
ccttccctga aggttcctcc tt                                                22


<210>  62
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  62
tgtatga                                                                  7


<210>  63
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  63
gtgtatga                                                                 8


<210>  64
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  64
cgtgtatga                                                                9


<210>  65
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  65
ccgtgtatga                                                              10


<210>  66
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  66
gccgtgtatg a                                                            11


<210>  67
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  67
agccgtgtat ga                                                           12


<210>  68
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  68
gagccgtgta tga                                                          13


<210>  69
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  69
agagccgtgt atga                                                         14


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  70
gagagccgtg tatga                                                        15


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  71
ggagagccgt gtatga                                                       16


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  72
aggagagccg tgtatga                                                      17


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  73
gaggagagcc gtgtatga                                                     18


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  74
agaggagagc cgtgtatga                                                    19


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  75
gagaggagag ccgtgtatga                                                   20


<210>  76
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  76
tgtatgac                                                                 8


<210>  77
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  77
gtgtatgac                                                                9


<210>  78
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  78
cgtgtatgac                                                              10


<210>  79
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  79
ccgtgtatga c                                                            11


<210>  80
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  80
gccgtgtatg ac                                                           12


<210>  81
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  81
agccgtgtat gac                                                          13


<210>  82
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  82
gagccgtgta tgac                                                         14


<210>  83
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  83
agagccgtgt atgac                                                        15


<210>  84
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  84
gagagccgtg tatgac                                                       16


<210>  85
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  85
ggagagccgt gtatgac                                                      17


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  86
aggagagccg tgtatgac                                                     18


<210>  87
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  87
gaggagagcc gtgtatgac                                                    19


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  88
agaggagagc cgtgtatgac                                                   20


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  89
gagaggagag ccgtgtatga c                                                 21


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  90
agagaggaga gccgtgtatg ac                                                22


<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSD-95 isoform 1

<400>  116

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu 
    50                  55                  60                  


Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
65                  70                  75                  80  


Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 
                85                  90                  95      


Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
            100                 105                 110         


Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 
        115                 120                 125             


Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
    130                 135                 140                 


Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu 
145                 150                 155                 160 


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
                165                 170                 175     


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
            180                 185                 190         


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
        195                 200                 205             


Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
    210                 215                 220                 


His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
225                 230                 235                 240 


Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala 
                245                 250                 255     


Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile 
            260                 265                 270         


Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro 
        275                 280                 285             


Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu 
    290                 295                 300                 


Glu Asp Ile Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser 
305                 310                 315                 320 


Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 
                325                 330                 335     


Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 
            340                 345                 350         


Leu Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 
        355                 360                 365             


Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln 
    370                 375                 380                 


Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe 
385                 390                 395                 400 


Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu 
                405                 410                 415     


Gly Ser Gly Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr 
            420                 425                 430         


Ile Arg Ala Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu 
        435                 440                 445             


Ser Gln Ala Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp 
    450                 455                 460                 


Ala Ser Asp Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 
465                 470                 475                 480 


Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 
                485                 490                 495     


Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly 
            500                 505                 510         


Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln 
        515                 520                 525             


Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys 
    530                 535                 540                 


Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly 
545                 550                 555                 560 


Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 
                565                 570                 575     


Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 
            580                 585                 590         


Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 
        595                 600                 605             


Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 
    610                 615                 620                 


His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala 
625                 630                 635                 640 


Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu 
                645                 650                 655     


Asn Val Leu Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys 
            660                 665                 670         


Ala Phe Asp Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 
        675                 680                 685             


Ser Ala Ile Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val 
    690                 695                 700                 


Lys Arg Val Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 
705                 710                 715                 720 


Arg Glu Arg Leu 
                


<210>  117
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSD-95 isoform 2

<400>  117

Met Ser Gln Arg Pro Arg Ala Pro Arg Ser Ala Leu Trp Leu Leu Ala 
1               5                   10                  15      


Pro Pro Leu Leu Arg Trp Ala Pro Pro Leu Leu Thr Val Leu His Ser 
            20                  25                  30          


Asp Leu Phe Gln Ala Leu Leu Asp Ile Leu Asp Tyr Tyr Glu Ala Ser 
        35                  40                  45              


Leu Ser Glu Ser Gln Lys Tyr Arg Tyr Gln Asp Glu Asp Thr Pro Pro 
    50                  55                  60                  


Leu Glu His Ser Pro Ala His Leu Pro Asn Gln Ala Asn Ser Pro Pro 
65                  70                  75                  80  


Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro Gly Tyr Glu Leu Gln 
                85                  90                  95      


Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr Leu Glu 
            100                 105                 110         


Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn 
        115                 120                 125             


Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile Ile Pro 
    130                 135                 140                 


Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp Ser Ile 
145                 150                 155                 160 


Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser Ala Ala 
                165                 170                 175     


Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Met 
            180                 185                 190         


Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile Lys 
        195                 200                 205             


Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln 
    210                 215                 220                 


His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly 
225                 230                 235                 240 


Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu 
                245                 250                 255     


Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala Val 
            260                 265                 270         


Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala Lys 
        275                 280                 285             


Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp Ile Thr 
    290                 295                 300                 


Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser Ser Tyr 
305                 310                 315                 320 


Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro Arg Arg 
                325                 330                 335     


Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile Pro Arg 
            340                 345                 350         


Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe 
        355                 360                 365             


Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile 
    370                 375                 380                 


Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp 
385                 390                 395                 400 


Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu 
                405                 410                 415     


Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile 
            420                 425                 430         


Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His 
        435                 440                 445             


Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly Thr Ala 
    450                 455                 460                 


Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala Leu Phe 
465                 470                 475                 480 


Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala Leu Ser 
                485                 490                 495     


Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp Glu Glu 
            500                 505                 510         


Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp Asp Ile 
        515                 520                 525             


Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp Ser Arg 
    530                 535                 540                 


Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly Arg Glu 
545                 550                 555                 560 


Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val His Tyr 
                565                 570                 575     


Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala Asn Asp 
            580                 585                 590         


Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
        595                 600                 605             


Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His 
    610                 615                 620                 


Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala His Lys 
625                 630                 635                 640 


Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr Ser Val 
                645                 650                 655     


Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile Leu Asp 
            660                 665                 670         


Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu His Pro 
        675                 680                 685             


Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu Glu Ile 
    690                 695                 700                 


Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp Arg Ala 
705                 710                 715                 720 


Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile Val Glu 
                725                 730                 735     


Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val Ile Glu 
            740                 745                 750         


Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg Leu 
        755                 760                 765         


<210>  118
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSD-95 isoform 3

<400>  118

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr 
    50                  55                  60                  


Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr 
65                  70                  75                  80  


Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile 
                85                  90                  95      


Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp 
            100                 105                 110         


Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser 
        115                 120                 125             


Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr 
    130                 135                 140                 


Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu 
145                 150                 155                 160 


Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly 
                165                 170                 175     


Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile 
            180                 185                 190         


Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys 
        195                 200                 205             


Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp 
    210                 215                 220                 


Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val 
225                 230                 235                 240 


Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp 
                245                 250                 255     


Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser 
            260                 265                 270         


Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro 
        275                 280                 285             


Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile 
    290                 295                 300                 


Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu 
305                 310                 315                 320 


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
                325                 330                 335     


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
            340                 345                 350         


Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser 
        355                 360                 365             


His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr 
    370                 375                 380                 


Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
385                 390                 395                 400 


Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly 
                405                 410                 415     


Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala 
            420                 425                 430         


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala 
        435                 440                 445             


Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp 
    450                 455                 460                 


Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp 
465                 470                 475                 480 


Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp 
                485                 490                 495     


Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly 
            500                 505                 510         


Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val 
        515                 520                 525             


His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala 
    530                 535                 540                 


Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val 
545                 550                 555                 560 


Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp 
                565                 570                 575     


Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala 
            580                 585                 590         


His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr 
        595                 600                 605             


Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile 
    610                 615                 620                 


Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu 
625                 630                 635                 640 


His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu 
                645                 650                 655     


Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp 
            660                 665                 670         


Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile 
        675                 680                 685             


Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val 
    690                 695                 700                 


Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg 
705                 710                 715                 720 


<210>  119
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synaptophysin isoform 1

<400>  119

Met Leu Leu Leu Ala Asp Met Asp Val Val Asn Gln Leu Val Ala Gly 
1               5                   10                  15      


Gly Gln Phe Arg Val Val Lys Glu Pro Leu Gly Phe Val Lys Val Leu 
            20                  25                  30          


Gln Trp Val Phe Ala Ile Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser 
        35                  40                  45              


Gly Glu Leu Gln Leu Ser Val Asp Cys Ala Asn Lys Thr Glu Ser Asp 
    50                  55                  60                  


Leu Ser Ile Glu Val Glu Phe Glu Tyr Pro Phe Arg Leu His Gln Val 
65                  70                  75                  80  


Tyr Phe Asp Ala Pro Thr Cys Arg Gly Gly Thr Thr Lys Val Phe Leu 
                85                  90                  95      


Val Gly Asp Tyr Ser Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val 
            100                 105                 110         


Phe Ala Phe Leu Tyr Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu 
        115                 120                 125             


Gln Asn Lys Tyr Arg Glu Asn Asn Lys Gly Pro Met Leu Asp Phe Leu 
    130                 135                 140                 


Ala Thr Ala Val Phe Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp 
145                 150                 155                 160 


Ala Lys Gly Leu Ser Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile 
                165                 170                 175     


Ile Lys Glu Met Pro Val Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu 
            180                 185                 190         


Leu Arg Asp Pro Val Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly 
        195                 200                 205             


Phe Leu Asn Leu Val Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys 
    210                 215                 220                 


Glu Thr Gly Trp Ala Ala Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro 
225                 230                 235                 240 


Glu Lys Gln Pro Ala Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly 
                245                 250                 255     


Gln Gly Pro Gly Gly Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly 
            260                 265                 270         


Gly Tyr Gln Pro Asp Tyr Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Tyr Gly Pro Gln Gly Asp Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly 
    290                 295                 300                 


Ala Pro Thr Ser Phe Ser Asn Gln Met 
305                 310             


<210>  120
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synaptophysin isoform 2

<400>  120

Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu Gln Asn Lys Tyr Arg Glu 
1               5                   10                  15      


Asn Asn Lys Gly Pro Met Leu Asp Phe Leu Ala Thr Ala Val Phe Ala 
            20                  25                  30          


Phe Met Trp Leu Val Ser Ser Ser Ala Trp Ala Lys Gly Leu Ser Asp 
        35                  40                  45              


Val Lys Met Ala Thr Asp Pro Glu Asn Ile Ile Lys Glu Met Pro Val 
    50                  55                  60                  


Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu Leu Arg Asp Pro Val Thr 
65                  70                  75                  80  


Ser Gly Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Leu Val Leu 
                85                  90                  95      


Trp Val Gly Asn Leu Trp Phe Val Phe Lys Glu Thr Gly Trp Ala Ala 
            100                 105                 110         


Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro Glu Lys Gln Pro Ala Pro 
        115                 120                 125             


Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly Gln Gly Pro Gly Gly Tyr 
    130                 135                 140                 


Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly Gly Tyr Gln Pro Asp Tyr 
145                 150                 155                 160 


Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly Tyr Gly Pro Gln Gly Asp 
                165                 170                 175     


Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly Ala Pro Thr Ser Phe Ser 
            180                 185                 190         


Asn Gln Met 
        195 


<210>  121
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caspase-3

<400>  121

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


