                         SEQUENCE LISTING

<110>  BIORCHESTRA CO., LTD.
 
<120>  USE OF MIRNA-485 INHIBITORS FOR TREATING DISEASES OR DISORDERS ASSOCIATED WITH ABNORMAL NLRP3 EXPRESSION

<130>  4366.043PC03

<150>  US 63/146,518
<151>  2021-02-05

<150>  US 63/146,519
<151>  2021-02-05

<150>  US 63/146,523
<151>  2021-02-05

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  1
gucauacacg gcucuccucu cu                                                22


<210>  2
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  2
uguauga                                                                  7


<210>  3
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  3
guguauga                                                                 8


<210>  4
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  4
cguguauga                                                                9


<210>  5
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  5
ccguguauga                                                              10


<210>  6
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  6
gccguguaug a                                                            11


<210>  7
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  7
agccguguau ga                                                           12


<210>  8
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  8
gagccgugua uga                                                          13


<210>  9
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  9
agagccgugu auga                                                         14


<210>  10
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  10
gagagccgug uauga                                                        15


<210>  11
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  11
ggagagccgu guauga                                                       16


<210>  12
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  12
aggagagccg uguauga                                                      17


<210>  13
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  13
gaggagagcc guguauga                                                     18


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  14
agaggagagc cguguauga                                                    19


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  15
gagaggagag ccguguauga                                                   20


<210>  16
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  16
uguaugac                                                                 8


<210>  17
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  17
guguaugac                                                                9


<210>  18
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  18
cguguaugac                                                              10


<210>  19
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  19
ccguguauga c                                                            11


<210>  20
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  20
gccguguaug ac                                                           12


<210>  21
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  21
agccguguau gac                                                          13


<210>  22
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  22
gagccgugua ugac                                                         14


<210>  23
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  23
agagccgugu augac                                                        15


<210>  24
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  24
gagagccgug uaugac                                                       16


<210>  25
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  25
ggagagccgu guaugac                                                      17


<210>  26
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  26
aggagagccg uguaugac                                                     18


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  27
gaggagagcc guguaugac                                                    19


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  28
agaggagagc cguguaugac                                                   20


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  29
gagaggagag ccguguauga c                                                 21


<210>  30
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  30
agagaggaga gccguguaug ac                                                22


<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  33
agaggcuggc cgugaugaau uc                                                22


<210>  34
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  34
agucauacac ggcucuccuc uc                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  35
agaggcuggc cgugaugaau uc                                                22


<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  49
ucauaca                                                                  7


<210>  50
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  50
gaggcug                                                                  7


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  51
cgaggtcgac ttcctaga                                                     18


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  52
catacacggc tctcctctct aaa                                               23


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  53
tcctgtggca tccatgaaac                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  54
caatgcctgg gtacatggtg                                                   20


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  55
ccaagtggag gagcagct                                                     18


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  56
gacaaggtac aacccatcgg                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  57
ttcgacacat gggataacga gg                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  58
tttttgctgt gagtcccgga g                                                 21


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  59
cagcctagca gcacgtaaat                                                   20


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  60
gaatcgagca ccagttacg                                                    19


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  61
ccttccctga aggttcctcc tt                                                22


<210>  62
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  62
tgtatga                                                                  7


<210>  63
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  63
gtgtatga                                                                 8


<210>  64
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  64
cgtgtatga                                                                9


<210>  65
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  65
ccgtgtatga                                                              10


<210>  66
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  66
gccgtgtatg a                                                            11


<210>  67
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  67
agccgtgtat ga                                                           12


<210>  68
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  68
gagccgtgta tga                                                          13


<210>  69
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  69
agagccgtgt atga                                                         14


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  70
gagagccgtg tatga                                                        15


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  71
ggagagccgt gtatga                                                       16


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  72
aggagagccg tgtatga                                                      17


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  73
gaggagagcc gtgtatga                                                     18


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  74
agaggagagc cgtgtatga                                                    19


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  75
gagaggagag ccgtgtatga                                                   20


<210>  76
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  76
tgtatgac                                                                 8


<210>  77
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  77
gtgtatgac                                                                9


<210>  78
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  78
cgtgtatgac                                                              10


<210>  79
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  79
ccgtgtatga c                                                            11


<210>  80
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  80
gccgtgtatg ac                                                           12


<210>  81
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  81
agccgtgtat gac                                                          13


<210>  82
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  82
gagccgtgta tgac                                                         14


<210>  83
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  83
agagccgtgt atgac                                                        15


<210>  84
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  84
gagagccgtg tatgac                                                       16


<210>  85
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  85
ggagagccgt gtatgac                                                      17


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  86
aggagagccg tgtatgac                                                     18


<210>  87
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  87
gaggagagcc gtgtatgac                                                    19


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  88
agaggagagc cgtgtatgac                                                   20


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  89
gagaggagag ccgtgtatga c                                                 21


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  90
agagaggaga gccgtgtatg ac                                                22


<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 isoform 2

<400>  123

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Trp Leu Gly Arg Cys Gly Leu Ser His 
    770                 775                 780                 


Glu Cys Cys Phe Asp Ile Ser Leu Val Leu Ser Ser Asn Gln Lys Leu 
785                 790                 795                 800 


Val Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg 
                805                 810                 815     


Leu Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu 
            820                 825                 830         


Trp Leu Val Ser Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala 
        835                 840                 845             


Ser Val Leu Ser Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu 
    850                 855                 860                 


Asn Ala Leu Gly Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys 
865                 870                 875                 880 


Asn Pro Gln Cys Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu 
                885                 890                 895     


Thr Ser Val Cys Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln 
            900                 905                 910         


Asn Leu Thr His Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly 
        915                 920                 925             


Ile Lys Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln 
    930                 935                 940                 


Val Leu Glu Leu Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp 
945                 950                 955                 960 


Leu Ser Thr Leu Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu 
                965                 970                 975     


Gly Asn Asn Asp Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val 
            980                 985                 990         


Leu Lys Gln Gln Ser Cys Leu Leu  Gln Asn Leu Gly Leu  Ser Glu Met 
        995                 1000                 1005             


Tyr Phe  Asn Tyr Glu Thr Lys  Ser Ala Leu Glu Thr  Leu Gln Glu 
    1010                 1015                 1020             


Glu Lys  Pro Glu Leu Thr Val  Val Phe Glu Pro Ser  Trp 
    1025                 1030                 1035     


<210>  124
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 isoform 1

<400>  124

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Gly Arg Cys Gly Leu Ser His Glu Cys Cys Phe Asp Ile Ser Leu Val 
                725                 730                 735     


Leu Ser Ser Asn Gln Lys Leu Val Glu Leu Asp Leu Ser Asp Asn Ala 
            740                 745                 750         


Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val Gly Leu Lys His Leu 
        755                 760                 765             


Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Asn Ser Gly Leu Thr Ser 
    770                 775                 780                 


Val Cys Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu 
785                 790                 795                 800 


Thr His Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly Ile Lys 
                805                 810                 815     


Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Val Leu 
            820                 825                 830         


Glu Leu Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp Leu Ser 
        835                 840                 845             


Thr Leu Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu Gly Asn 
    850                 855                 860                 


Asn Asp Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val Leu Lys 
865                 870                 875                 880 


Gln Gln Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met Tyr Phe 
                885                 890                 895     


Asn Tyr Glu Thr Lys Ser Ala Leu Glu Thr Leu Gln Glu Glu Lys Pro 
            900                 905                 910         


Glu Leu Thr Val Val Phe Glu Pro Ser Trp 
        915                 920         


<210>  125
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 isoform 3

<400>  125

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly 
705                 710                 715                 


<210>  126
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 isoform 4

<400>  126

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Gly Arg Cys Gly Leu Ser His Glu Cys Cys Phe Asp Ile Ser Leu Val 
                725                 730                 735     


Leu Ser Ser Asn Gln Lys Leu Val Glu Leu Asp Leu Ser Asp Asn Ala 
            740                 745                 750         


Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val Gly Leu Lys His Leu 
        755                 760                 765             


Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser Cys Cys Leu Thr Ser 
    770                 775                 780                 


Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser Thr Ser His Ser Leu 
785                 790                 795                 800 


Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Ala 
                805                 810                 815     


Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys Asn Leu Gln Lys Leu 
            820                 825                 830         


Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys Cys Ser Ala Leu Ser 
        835                 840                 845             


Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His Leu Tyr Leu Arg Gly 
    850                 855                 860                 


Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu Cys Glu Gly Leu Leu 
865                 870                 875                 880 


His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu Asp Asn Cys Asn Leu 
                885                 890                 895     


Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu Thr Ser Ser Gln 
            900                 905                 910         


Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp Leu Gly Asp Leu Gly 
        915                 920                 925             


Val Met Met Phe Cys Glu Val Leu Lys Gln Gln Ser Cys Leu Leu Gln 
    930                 935                 940                 


Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr Glu Thr Lys Ser Ala 
945                 950                 955                 960 


Leu Glu Thr Leu Gln Glu Glu Lys Pro Glu Leu Thr Val Val Phe Glu 
                965                 970                 975     


Pro Ser Trp 
            


<210>  127
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 isoform 5

<400>  127

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Trp Leu Gly Arg Cys Gly Leu Ser His 
    770                 775                 780                 


Glu Cys Cys Phe Asp Ile Ser Leu Val Leu Ser Ser Asn Gln Lys Leu 
785                 790                 795                 800 


Val Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg 
                805                 810                 815     


Leu Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu 
            820                 825                 830         


Trp Leu Val Asn Ser Gly Leu Thr Ser Val Cys Cys Ser Ala Leu Ser 
        835                 840                 845             


Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His Leu Tyr Leu Arg Gly 
    850                 855                 860                 


Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu Cys Glu Gly Leu Leu 
865                 870                 875                 880 


His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu Asp Asn Cys Asn Leu 
                885                 890                 895     


Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu Thr Ser Ser Gln 
            900                 905                 910         


Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp Leu Gly Asp Leu Gly 
        915                 920                 925             


Val Met Met Phe Cys Glu Val Leu Lys Gln Gln Ser Cys Leu Leu Gln 
    930                 935                 940                 


Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr Glu Thr Lys Ser Ala 
945                 950                 955                 960 


Leu Glu Thr Leu Gln Glu Glu Lys Pro Glu Leu Thr Val Val Phe Glu 
                965                 970                 975     


Pro Ser Trp 
            


<210>  128
<211>  1016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLRP3 isoform 6

<400>  128

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Cys Asn Gln Lys Leu Val Glu Leu Asp 
    770                 775                 780                 


Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val 
785                 790                 795                 800 


Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser 
                805                 810                 815     


Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser 
            820                 825                 830         


Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly 
        835                 840                 845             


Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys 
    850                 855                 860                 


Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys 
865                 870                 875                 880 


Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His 
                885                 890                 895     


Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu 
            900                 905                 910         


Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu 
        915                 920                 925             


Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu 
    930                 935                 940                 


Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp 
945                 950                 955                 960 


Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val Leu Lys Gln Gln 
                965                 970                 975     


Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr 
            980                 985                 990         


Glu Thr Lys Ser Ala Leu Glu Thr  Leu Gln Glu Glu Lys  Pro Glu Leu 
        995                 1000                 1005             


Thr Val  Val Phe Glu Pro Ser  Trp 
    1010                 1015     


<210>  129
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse NLRP3 forward primer

<400>  129
attacccgcc cgagaaagg                                                    19


<210>  130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse NLRP3 reverse primer

<400>  130
tcgcagcaaa gatccacaca g                                                 21


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH forward primer

<400>  131
tgtgtccgtc ctggatctga                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH reverse primer

<400>  132
cctgcttcac caccttcttg                                                   20


<210>  133
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASC forward primer

<400>  133
cttgtcaggg gatgaactca aaa                                               23


<210>  134
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASC reverse primer

<400>  134
gccatacgac tccagatagt agc                                               23


<210>  135
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTBP1 isoform 1

<400>  135

Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg 
1               5                   10                  15      


Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu 
            20                  25                  30          


Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys Asp Val 
        35                  40                  45              


Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile His Glu 
    50                  55                  60                  


Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Thr Ile Thr 
65                  70                  75                  80  


Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val 
                85                  90                  95      


Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp 
            100                 105                 110         


Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Thr 
        115                 120                 125             


Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Thr 
    130                 135                 140                 


Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser Val Glu 
145                 150                 155                 160 


Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr 
                165                 170                 175     


Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg 
            180                 185                 190         


Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser 
        195                 200                 205             


Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Thr Leu Gln 
    210                 215                 220                 


Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu His Cys Gly Leu Asn 
225                 230                 235                 240 


Glu His Asn His His Leu Ile Asn Asp Phe Thr Val Lys Gln Met Arg 
                245                 250                 255     


Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly Gly Leu Val Asp Glu 
            260                 265                 270         


Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala 
        275                 280                 285             


Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu 
    290                 295                 300                 


Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Ala Ala Trp Tyr Ser 
305                 310                 315                 320 


Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg 
                325                 330                 335     


Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn 
            340                 345                 350         


Lys Asp His Leu Thr Ala Ala Thr His Trp Ala Ser Met Asp Pro Ala 
        355                 360                 365             


Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly 
    370                 375                 380                 


Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala Ala Val Glu Gly Ile 
385                 390                 395                 400 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
                405                 410                 415     


Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val Lys Pro Glu Ala Asp 
            420                 425                 430         


Arg Asp His Ala Ser Asp Gln Leu 
        435                 440 


<210>  136
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTBP1 isoform 2

<400>  136

Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg 
1               5                   10                  15      


Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu 
            20                  25                  30          


Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys Asp Val 
        35                  40                  45              


Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile His Glu 
    50                  55                  60                  


Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Thr Ile Thr 
65                  70                  75                  80  


Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val 
                85                  90                  95      


Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp 
            100                 105                 110         


Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Thr 
        115                 120                 125             


Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Thr 
    130                 135                 140                 


Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser Val Glu 
145                 150                 155                 160 


Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr 
                165                 170                 175     


Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg 
            180                 185                 190         


Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser 
        195                 200                 205             


Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Thr Leu Gln 
    210                 215                 220                 


Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu His Cys Gly Leu Asn 
225                 230                 235                 240 


Glu His Asn His His Leu Ile Asn Asp Phe Thr Val Lys Gln Met Arg 
                245                 250                 255     


Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly Gly Leu Val Asp Glu 
            260                 265                 270         


Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala 
        275                 280                 285             


Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu 
    290                 295                 300                 


Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Ala Ala Trp Tyr Ser 
305                 310                 315                 320 


Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg 
                325                 330                 335     


Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn 
            340                 345                 350         


Lys Asp His Leu Thr Ala Ala Thr His Trp Ala Ser Met Asp Pro Ala 
        355                 360                 365             


Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly 
    370                 375                 380                 


Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala Ala Val Glu Gly Ile 
385                 390                 395                 400 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
                405                 410                 415     


Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val Lys Pro Glu Ala Asp 
            420                 425                 430         


Arg Asp His Ala Ser Asp Gln Leu 
        435                 440 


<210>  137
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIP6 isoform 1

<400>  137

Met Ser Gly Pro Thr Trp Leu Pro Pro Lys Gln Pro Glu Pro Ala Arg 
1               5                   10                  15      


Ala Pro Gln Gly Arg Ala Ile Pro Arg Gly Thr Pro Gly Pro Pro Pro 
            20                  25                  30          


Ala His Gly Ala Ala Leu Gln Pro His Pro Arg Val Asn Phe Cys Pro 
        35                  40                  45              


Leu Pro Ser Glu Gln Cys Tyr Gln Ala Pro Gly Gly Pro Glu Asp Arg 
    50                  55                  60                  


Gly Pro Ala Trp Val Gly Ser His Gly Val Leu Gln His Thr Gln Gly 
65                  70                  75                  80  


Leu Pro Ala Asp Arg Gly Gly Leu Arg Pro Gly Ser Leu Asp Ala Glu 
                85                  90                  95      


Ile Asp Leu Leu Ser Ser Thr Leu Ala Glu Leu Asn Gly Gly Arg Gly 
            100                 105                 110         


His Ala Ser Arg Arg Pro Asp Arg Gln Ala Tyr Glu Pro Pro Pro Pro 
        115                 120                 125             


Pro Ala Tyr Arg Thr Gly Ser Leu Lys Pro Asn Pro Ala Ser Pro Leu 
    130                 135                 140                 


Pro Ala Ser Pro Tyr Gly Gly Pro Thr Pro Ala Ser Tyr Thr Thr Ala 
145                 150                 155                 160 


Ser Thr Pro Ala Gly Pro Ala Phe Pro Val Gln Val Lys Val Ala Gln 
                165                 170                 175     


Pro Val Arg Gly Cys Gly Pro Pro Arg Arg Gly Ala Ser Gln Ala Ser 
            180                 185                 190         


Gly Pro Leu Pro Gly Pro His Phe Pro Leu Pro Gly Arg Gly Glu Val 
        195                 200                 205             


Trp Gly Pro Gly Tyr Arg Ser Gln Arg Glu Pro Gly Pro Gly Ala Lys 
    210                 215                 220                 


Glu Glu Ala Ala Gly Val Ser Gly Pro Ala Gly Arg Gly Arg Gly Gly 
225                 230                 235                 240 


Glu His Gly Pro Gln Val Pro Leu Ser Gln Pro Pro Glu Asp Glu Leu 
                245                 250                 255     


Asp Arg Leu Thr Lys Lys Leu Val His Asp Met Asn His Pro Pro Ser 
            260                 265                 270         


Gly Glu Tyr Phe Gly Gln Cys Gly Gly Cys Gly Glu Asp Val Val Gly 
        275                 280                 285             


Asp Gly Ala Gly Val Val Ala Leu Asp Arg Val Phe His Val Gly Cys 
    290                 295                 300                 


Phe Val Cys Ser Thr Cys Arg Ala Gln Leu Arg Gly Gln His Phe Tyr 
305                 310                 315                 320 


Ala Val Glu Arg Arg Ala Tyr Cys Glu Gly Cys Tyr Val Ala Thr Leu 
                325                 330                 335     


Glu Lys Cys Ala Thr Cys Ser Gln Pro Ile Leu Asp Arg Ile Leu Arg 
            340                 345                 350         


Ala Met Gly Lys Ala Tyr His Pro Gly Cys Phe Thr Cys Val Val Cys 
        355                 360                 365             


His Arg Gly Leu Asp Gly Ile Pro Phe Thr Val Asp Ala Thr Ser Gln 
    370                 375                 380                 


Ile His Cys Ile Glu Asp Phe His Arg Lys Phe Ala Pro Arg Cys Ser 
385                 390                 395                 400 


Val Cys Gly Gly Ala Ile Met Pro Glu Pro Gly Gln Glu Glu Thr Val 
                405                 410                 415     


Arg Ile Val Ala Leu Asp Arg Ser Phe His Ile Gly Cys Tyr Lys Cys 
            420                 425                 430         


Glu Glu Cys Gly Leu Leu Leu Ser Ser Glu Gly Glu Cys Gln Gly Cys 
        435                 440                 445             


Tyr Pro 
    450 


<210>  138
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIP6 isoform 2

<400>  138

Met Ser Gly Pro Thr Trp Leu Pro Pro Lys Gln Pro Glu Pro Ala Arg 
1               5                   10                  15      


Ala Pro Gln Gly Arg Ala Ile Pro Arg Gly Thr Pro Gly Pro Pro Pro 
            20                  25                  30          


Ala His Gly Ala Val Leu Pro Gly Pro Arg Gly Thr Gly Gly Ser Gly 
        35                  40                  45              


Ala Gly Val Gly Gly Val Pro Trp Ser Thr Pro Ala His Ala Gly Ala 
    50                  55                  60                  


Pro Cys Arg Gln Gly Gly Pro Ser Pro Trp Lys Pro Gly Arg Arg Asp 
65                  70                  75                  80  


Arg Leu Ala Glu Gln His Ala Gly Arg Ala Glu Trp Gly Ser Gly Ser 
                85                  90                  95      


Cys Val Thr Ala Thr Arg Pro Thr Gly 
            100                 105 


<210>  139
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIP6 isoform 3

<400>  139

Met Ser Gly Pro Thr Trp Leu Pro Pro Lys Gln Pro Glu Pro Ala Arg 
1               5                   10                  15      


Ala Pro Gln Gly Arg Ala Ile Pro Arg Gly Thr Pro Gly Pro Pro Pro 
            20                  25                  30          


Ala His Gly Ala Gly Ala Pro Cys Arg Gln Gly Gly Pro Ser Pro Trp 
        35                  40                  45              


Lys Pro Gly Arg Arg Asp Arg Leu Ala Glu Gln His Ala Gly Arg Ala 
    50                  55                  60                  


Glu Trp Gly Ser Gly Ser Cys Val Thr Ala Thr Arg Pro Thr Gly Ile 
65                  70                  75                  80  


